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Researcher Information

last modified：2024/01/08

Professor　YOKOYAMA Shigeru

Mail

Faculty, Affiliation

Research Center for Child Mental Development
Professor and Director

College and School Educational Field

Division of Medical Sciences, Graduate School of Medical Science
Division of Medicine, Graduate School of Medical Science
United Graduate School of Child Depelopment
School of Medicine, College of Medical, Pharmaceutical and Health Sciences

Laboratory

Center for Child Mental Development　TEL:076-265-2457　FAX:076-234-4213

Academic Background

【Academic background(Doctoral/Master's Degree)】
Kanazawa University　Doctor　Graduate School, Division of Medicine　Immunobiology　198803　Accomplished credits for doctoral program
【Academic background(Bachelor's Degree)】
Kanazawa University　198503
【Degree】
MD, PhD

Career

Year & Month of Birth

1960/11

Academic Society

Japanese Society of Neurochemistry
The Japanese Biochemical Society
Society for Neuroscience
The Moleular Biology Society of Japan
Japanese Society for Biological Sciences in Space
The Physiological Society of Japan

Award

The Physiological Society of Japan
○Grant-in-aid from Japan Heart Foundation(1988/12)
○Grant-in-aid from Saburo Matsubara Memorial Psychiatry Foundation(1990/03)
○Grant-in-aid from Foundation for Geriatric Medicine(1990/04)
○Grant-in aid from Kowa Life Science Foundation(1994/10)

Specialities

neurochemistry and neuropharmacology、Neurophysiology/General neuroscience

Speciality Keywords

neurochemistry, neurophysiology, and molecular biology

Research Themes

Books

  • 　 Inflammatory cytokines in degeneration, regeneration, and maintenance of sciatic nerve.　Nova Science Publishers　2011/04
  • 　12. Higashida, H., Munesue, T., Yokoyama, S., Hashii, M., Koizumi, K., and Matsushima, A.　A missense mutation in CD38 associated with autism spectrum disorder in three pedigrees.　InTech　2011/04
  • 　Higashida, H., Jin, D., Liu, H.-X., Lopatina, O., Yokoyama, S., Koizumi, K., Hashii, M., Islam, S., Md., Hayashi, K., and Munesue, T.　Social memory, mental care and oxytocin secretion, but not vasopressin release, require CD38 in mice. In: Neurobiology of the Parental Brain　Academic Press　2008
  • 　Higashida, H., Zhang, J.-S., Yokoyama, S., Noda, M., Zhong, Z.-G., Mochida, S., and Egorova, A.　Sympathetic potentiation of cyclic ADP-ribose formation in rat cardiac myocytes.　Kluwer Academic/Plenum Publishers　2002
  • 　Chen, X.-L., Zhong, Z.-G., Yokoyama S., Bark, C., Meister, B., Berggen, P.-O., Roder, J., Higashida, H., and Jeromin, A.　Overexpression of rat neuronal calcium sensor-1 in rodent NG108-15 cells enhances functional synapse formation and release of acetylcholine.　Cambridge University Press　532　Pt3　649-659　2001/05

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  • 　Higashida, H., Yokoyama, S., Hashii, M., and Taketo, M.　Slow synaptic responses in neuronal tumor cells: dual regulation of ADP-ribosyl cyclase and inhibition of M-current by muscarinic receptor stimulation.　Springer　2000
  • 　Three types of cerebellar voltage-gated K+ currents expressed in Xenopus oocytes.　Springer　2000
  • 　Zhong, Z.-G., Yokoyama, S., Noda, M., and Higashida, H.　Role of adhesion molecule L1 in neurite outgrowth and functional synapse formation.　Springer　2000
  • 　Yokoyama, S., Takeda, H., and Higashida, H.　B2 bradykinin receptor in neuronal cells: a genetic aspect.　Elsevier　2000
  • 　Higashida, H., Yokoyama, S., Hoshi, N., Hashii, M., Noda, M., and Zhong, Z.-G.　Preparative study on neuro-muscular synapse formation and hormone-induced calcium mobilizing response in space - a proposal for updated experiments - Proceedings of the Twentieth International Symposium on Space Technology and Science　Kokusai Bunken Insatsusha Co., Ltd.　1996

Papers

  • 　Intracellular calcium elevation induced by extracellular cyclic-ADP-ribose or oxytocin is temperature-sensitive in rodent NG108-15 neuronal cells with or without expression of human oxytocin receptors. 　14. Amina, S., Hashii, M., Ma, W.-J., Yokoyama, S., Lopatina, O., Liu, H.-X., Islam, M. S., Graeff, R., Lee, H.-C., and Higashiga, H.　JOURNAL OF NEUROENDOCRINOLOGY　22　5　460-466　2010/05
  • 　Interleukin-6 upregulates the expression of PMP22 in cultured rat Schwann cells via a JAK2-dependent pathway.　Ito, T., Ikeda, K., Tomita, K., and Yokoyama, S.　NEUROSCIENCE LETTERS　472　2　104-108　2010/03
  • 　Two genetic variants in CD38 in subjects with autism spectrum disorders and controls.　13. Munesue, T.,* Yokoyama, S.,* Nakamura, K.,* Anitha, A.,* Yamada, K.,* Hayashi, K., Asaka, T., Liu, H.-X., Jin, D., Koizumi, K., Islam, Md. S., Huang, J.-J., Ma, W.-J., Kim, U.-H., Kim, S.-J., Park, K., Kim, D., Kikuchi, M., Ono. Y., Nakatani, H., Suda, S., Miyachi, T., Hirai, H., Salmina, A., Pichugina, Y. A., Soumarokov, A. A., Takei, N., Mori, N., Tsujii, M., Sugiyama, T., Yagi, K., Yamagishi, M., Sasaki, T., Yamasue, H., Kato, N., Hashimoto, R., Taniike, M., Hayashi, Y., Hamada, J., Suzuki, S., Ooi, A., Noda, M., Kamiyama, Y., Kido, M. A., Lopatina, O., Hashii, M., Amina, S. S., Malvasi, F., Huang, E. J., Zhang, J.-S., Shimizu, N., Yoshikawa, T., Matsushima, A., Minabe, Y., and Higashida, H.　NEUROSCIENCE RESEARCH　67　2　181-191　2010/06
  • 　Reply to the letter by Peters, A. M. regarding the article "Quantitative regional blood-flow measurements in exercising skeletal muscle based on 99mTc-pertechnetate clearance".　Seto, M., Bunko, H., Shuke, N., Takahashi, K., Sakaibori, Y., Terada, H., Imabayashi, E., Kuji, I., Matsuda, H., and Yokoyama, S.　NUCLEAR MEDICINE COMMUNICATIONS　30　4　320-321　2009/04
  • 　Locomotor activity, ultrasonic vocalization, oxytocin levels in infant CD38 knockout mice.　Liu, H.-X., Lopatina, O., Higashida, C., Tsuji, T., Kato, I., Takasawa-S., Okamoto, H., Yokoyama, S., and Higashida, H.　NEUROSCIENCE LETTERS　448　1　67-70　2008/12

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  • 　Quantitative regional blood-flow measurements in exercising skeletal muscle based on 99mTc-pertechnetate clearance.　Seto, M., Bunko, H., Shuke, N., Takahashi, K., Sakaibori, Y., Terada, H., Imabayashi, E., Kuji, I., Matsuda, H., and Yokoyama, S.　NUCLEAR MEDICINE COMMUNICATIONS　29　9　770-774　2008/09
  • 　Cyclic ADP-ribose as a universal calcium signal molecule in the nervous system.　Higashida, H., Salmina, A. B., Olovyannikova, R., Hashii, M., Yokoyama, S., Koizumi, K., Jin, D., Liu, H.-X., Lopatina, O., Amita, S., Islam, S. Md., Jun, H.-J., and Noda, M.　NEUROCHEMISTRY INTERNATIONAL　51　2-4　192-199　2007/09
  • 　Oxytocin released from mouse hypothalamus and nerve endings by extracellular application of beta-NAD+ and cyclic ADP ribose.　Jin D., Liu, X.-X., Lopatina, O., Hashii, M., Yokoyama, S., Koizumi, K., Amina, S., Shuto, S., Shiraishi, Y., Tanaka, S., and Higashida, H.　Nature Protocols (Protocols Network)　10.1038　nprot.2007　214　2007/04
  • 　CD38 is critical for social behavior by regulating oxytocin secretion.　22. Jin, D., Liu, H.-X., Hirai, H., Torashima, T., Nagai, T., Lopatina, O., Schayder, N., Yamada, K., Noda, M., Seike, T., Fujita, K., Takasawa, S., Yokoyama, S., Koizumi, K., Shiraishi, M., Tanaka, S., Hashii, M., Yoshihara, T., Higashida, K., Islam, Md., Yamada, N., Hayashi, K., Noguchi, N., Kato, I., Okamoto, H., Matsushima, A., Salmina, A., Munesue, T., Shimizu, N., Mochida, S., Asano, M., and Higashida, H　NATURE　446　7131　41-45　2007/03
  • 　Bradykinin activates ADP-ribosyl cyclase in neuroblastoma cells: intracellular concentration decrease in NAD and increase in cyclic ADP-ribose.　Higashida, H., Salmina, A., Hashii, M., Yokoyama, S., Zhang, J.-S., Noda, M., Zhong, Z.-H., and Jin, D.　FEBS LETTERS　580　20　4857-4860　2006/09
  • 　Overexpression of constitutively active form of human CD38/ADP-ribosyl cyclase enhances acetylcholine-induced M(KCNQ)-current inhibition in rodent NG108-15 neuroblastoma cells.　Higashida, H., Bowden, S. E. H., Yokoyama, S., Egorova, A., Hashii, M., Hoshi, N., Zhang, J.-S., Knijnik, R., Noda, M., Zhong, Z.-G., Takeda, H., Akita, T., Kuba, K., Yamagishi, S., Shimizu, N., Takasawa, S., Okamoto, H., and Robbins, J.　NEUROSCIENCE RESEARCH　580　20　4857-4860　2007/03
  • 　Induction of tumor necrosis factor-alpha in Schwann cells after gradual elongation of rat sciatic nerve.　Hagiwara, N., Ikeda, K., Higashida, H., Tomita, K., and Yokoyama, S.　J. Orthop. Sci.　10　6　614-621　2005/11
  • 　Induction of interleukin-6 in dorsal root ganglion neurons after gradual elongation of rat sciatic nerve.　Osamura, N., Ikeda, K., Ito T., Higashida, H., Tomita, K., and Yokoyama, S.　EXPERIMENTAL NEUROLOGY　195　1　61-70　2005/09
  • 　Cyclin-dependent kinase 5 activators p35 and p39 facilitate formation of functional synapses.　Johansson, J. U., Lilja, L., Chen, X.-L., Higashida, H., Meister, B., Noda, M., Zhong, Z.-G., Yokoyama, S., Berggren, P.-O., and Bark, C.　MOLECULAR BRAIN RESEARCH　138　2　215-227　2005/08
  • 　Protein kinase C bound with A-kinase anchoring protein is involved in muscarinic receptor-activated modulation of M-type KCNQ potassium channels.　Higashida, H., Hoshi, N., Zhang, J.-S., Yokoyama, S., Hashii, M., Duo, J., Noda, M., and Robbins, J.　NEUROSCIENCE RESEARCH　51　3　231-234　2005/03
  • 　AKAP150 signaling complex promotes suppression of the M-current by muscarinic agonists.　Hoshi, N., Zhang, J.-S., Omaki, M., Takeuchi, T., Yokoyama, S., Wanaverbecq, N., Langeberg, L., Yoneda, Y., Scott, J. D., Brown, D. A., and Higashida, H.　NATURE NEUROSCIENCE　6　6　564-571　2003/06
  • 　Subtype-specific coupling with ADP-ribosyl cyclase of metabotropic glutamate receptors in retina, cervical ganglion and NG108-15 cells.　Higashida, H., Mochida, S., Chen, X.-L., Shin, Y., Zhang, J.-S., Noda, M., Hossain, K. Z., Hoshi, N., Hashii, M., Shigemoto, R., Nakanishi, S., Fukuda, Y., and Yokoyama, S.　JOURNAL OF NEUROCHEMISTRY　23　4　1148-1158　2003/06
  • 　Modulation of the Kv3.1b potassium channel isoform adjusts the fidelity of the firing pattern of auditory neurons.　Journal of Neuroscience　23　4　1133-1141　2003/02
  • 　Downregulation of vascular endothelial growth factor and its receptors in the kidney in rats with puromycin aminonucleoside nephrosis.　Fan, L., Wakayama, T., Yokoyama, S., Amano, O., and Iseki, S.　NEPHRON　90　95-102　2002
  • 　Enhanced invasiveness of pancreatic adenocarcinoma cells transfected with cationic trypsinogen cDNA.　Tajima, S., Ohta, T., Elnemr, A., Yasui, T., Kitagawa, H., Fushida, S., Kayahara, M., Miwa, K., Wakayama, T., Iseki, S., and Yokoyama, S.　INTERNATIONAL JOURNAL OF CANCER　95　5　699-704　2001/12
  • 　Sympathetic potentiation of cyclic ADP-ribose formation in rat cardiac myocytes.　Higashida, H., Egorova, A., Higashida, C., Zhong, Z.-G., Yokoyama, S., Noda, M., and Zhang, J.-S.　JOURNAL OF BIOLOGICAL CHEMISTRY　274　47　33348-33354　1999/11
  • 　Localization of B2 bradykinin receptor mRNA in the rat retina and sclerocornea.　Takeda, H., Kimura, Y., Higashida, H., and Yokoyama, S.　IMMUNOPHARMACOLOGY　45　1-3　51-55　1999/12
  • 　Expression of Kv1.2 potassium channels in rat sensory ganglia: an immunohistochemical study.　ANNALS OF THE NEW YORK ACADEMY OF SCIENCES　868　454-457　1999/04
  • 　KCR1, a membrane protein that facilitates functional expression of non-inactivating K+ currents associates with rat EAG voltage-dependent K+ channels.　Hoshi, N., Takahashi, H., Shahidullah, M., Yokoyama, S., and Higashida, H.　J. Biol. Chem.　273　36　23080-23085　1998/09
  • 　Muscarinic acetylcholine receptor subtypes in the human iris.　Ishizaka, N., Noda, M., Yokoyama, S., Kawasaki, K., Yamamoto, M., and Higashida, H.　BRAIN RESEARCH　787　2　344-347　1998/03
  • 　Muscarinic receptor-mediated dual regulation of ADP-ribosyl cyclase in NG108-15 neuronal cell membranes.　JOURNAL OF BIOLOGICAL CHEMISTRY　272　50　31272-31277　1997/12
  • 　Inositol-1,3,4,5-tetrakisphosphate binding sites in control and ras-transformed NIH/3T3 fibroblasts.　Biochem. Biophys. Res. Commun.　239　1　349-352　1997/10
  • 　Overexpression of adhesion molecule L1 in NG108-15 neuroblastoma x glioma hybrid cells enhances dibutyryl cAMP-induced neurite outgrowth and functional synapse formation in myotubes.　Zhong, Z.-G., Yokoyama, S., Noda, M., and Higashida, H.　JOURNAL OF NEUROCHEMISTRY　68　6　2291-2299　1997/06
  • 　Ca2+ release and Ca2+ influx in Chinese hamster ovary cells expressing the cloned mouse bradykinin B2 receptor: tyrosine kinase inhibition-sensitive and -insensitive processes.　Taketo, M., Yokoyama, S., Kimura, Y., and Higashida, H.　BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS　1355　1　89-98　1997/01
  • 　Sodium channel alpha-subunit mRNAs I, II, III, NaG, Na6 and hNE (PN1): Different expression pattern in developing rat nervous system.　Felts, P. A., Yokoyama, S., Dib-Hajj, S., Black, J. A., and Waxman, S. G.　MOLECULAR BRAIN RESEARCH　45　71-82　1997
  • 　Bradykinin B2 receptor-induced and inositol tetrakisphosphate-evoked Ca2+ entry is sensitive to a protein tyrosine phosphorylation inhibitor in ras-transformed NIH/3T3 fibroblasts.　Hashii, M., Nakashima, S., Yokoyama, S., Enomoto, K-i., Minabe, Y., Nozawa, Y., and Higashida, H.　BIOCHEMICAL JOURNAL　319　Pt2　649-656　1996/10
  • 　Slow inactivation conserved in heteromultimeric voltage-gated K+ channels between Shaker (Kv1) and Shaw (Kv3) subfamilies.　Shahidullah, M., Hoshi, N., Yokoyama, S., Kawamura, T., and Higashida, H.　FEBS LETTERS　371　3　301-310　1995/09
  • 　Microheterogeneity in heteromultimeric assemblies formed by Shaker (Kv1) and Shaw (Kv3) subfamilies of voltage-gated K+ channels.　Shahidullah, M., Hoshi, N., Yokoyama, S., and Higashida, H.　PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES　261　1362　309-317　1995/09
  • 　Whole-cell analysis of NGK2 (mKv3.1a) K+ channels stably expressed in mouse fibroblast cells.　Kawamura, T., Enomoto, K-i., Yokoyama, S., Hoshi, N., Yamashita, J., and Higashida, H.　NEUROSCIENCE LETTERS　197　2　164-166　1995/09
  • 　Overexpression of choline acetyltransferase reconstitutes discrete acetylcholine release in synapse formation-defective neuroblastoma cells.　Zhong, Z.-G., Misawa, H., Furuya, S., Kimura, Y., Noda, M., Yokoyama, S., and Higashida, H.　JOURNAL OF PHYSIOLOGY-PARIS　89　3　137-145　1995
  • 　Mouse B2 bradykinin receptor gene maps to distal chromosome 12.　Taketo, M., Yokoyama, S., Rochelle, J., Kimura, Y., Higashida, H., Taketo, M., and Seldin, M. F.　GENOMICS　27　1　222-223　1995/05
  • 　B2 bradykinin receptors in NG108-15 cells: cDNA cloning and functional expression.　Yokoyama, S., Kimura, Y., Taketo, M., Black, J. A., Ransom, B. R., and Higashida, H.　BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　200　1　634-641　1994/04
  • 　Sodium channel mRNAs in cultured spinal cord astrocytes: in situ hybridization in identified cell types.　Black, J. A., Yokoyama, S., Waxman, S. G., Oh, Y., Zur, K. B., Sontheimer, H., Higashida, H., and Ransom, B. R.　MOLECULAR BRAIN RESEARCH　23　3　235-245　1994/05
  • 　Sodium channel mRNA I, II and III in the CNS: Cell-specific expression.　Black, J. A., Yokoyama, S., Higashida, H., Ransom, B. R., and Waxman, S. G.　MOLECULAR BRAIN RESEARCH　22　1-4　275-289　1994/04
  • 　Coupling of m2 and m4 muscarinic acetylcholine receptor subtypes to Ca2+ -dependent K+ channels in transformed NL308 neuroblastoma x fibroblast hybrid cells.　Noda, M., Katayama, M., Brown, D. A., Robbins, J., Marsh, S. J., Ishizaka, N., Fukuda, K., Hoshi, N., Yokoyama, S., and Higashida, H.　PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES　251　1332　215-224　1993/03
  • 　Charybdotoxin, dendrotoxin and mast cell degranulating peptide block the voltage-activated K+ current of fibroblast cells stably transfected with NGK1 (Kv1.2) K+ channel complementary DNA.　Werkman, T. R., Kawamura, T., Yokoyama, S., Higashida, H., and Rogawski, M. A.　NEUROSCIENCE　50　4　935-946　1992/10
  • 　Potassium channels cloned from neuroblastoma cells display slowly inactivating outward currents in Xenopus oocytes.　Ito, Y., Yokoyama, S., and Higashida, H.　PROCEEDINGS OF THE ROYAL SOCIETY OF LONDON SERIES B-BIOLOGICAL SCIENCES　248　95-101　1992/05
  • 　Phosphoinositides and synaptic function in NG108-15 neuroblastoma x glioma hybrid cells.　Higashida, H., Yokoyama, S., Hoshi, N., Myojo, Y., Kawamura, T., Ito, Y., Hashii, M., Sagara, J., and Furuya, K.　COMPARATIVE BIOCHEMISTRY AND PHYSIOLOGY C-TOXICOLOGY & PHARMACOLOGY　1991
  • 　Post-transcriptional regulation of complement C4 in low C4-producing strain of mouse.　Nakayama, K., Pattanakitsakul, S-N., Yokoyama, S., Kimura, H., Nonaka, M., and Takahashi, M.　IMMUNOGENETICS　31　5-6　361-367　1990
  • 　Bradykinin induces inositol 1,4,5-trisphosphate-dependent hyperpolarization in K+ M-current deficient hybrid NL308 cells: Comparison with NG108-15 neuroblastoma x glioma hybrid cells.　Higashida, H., Okano, Y., Hoshi, N., Yada, Y., Yokoyama, S., Asaga, T., Fu, T., and Nozawa, Y.　GLIA　3　1　1-12　1990
  • 　Potassium channels from NG108-15 neuroblastoma-glioma hybrid cells: Primary structure and functional expression from cDNAs.　Yokoyama, S., Imoto, K., Kawamura, T., Higashida, H., Iwabe, N., Miyata, T., and Numa, S.　FEBS LETTERS　259　1　37-42　1989/12
  • 　Retroviral expression of the human IL2 gene in a murine T cell line results in cell growth autonomy and tumorigenicity.　Yamada, G., Kitamura, Y., Sonoda, H., Harada, H., Taki, S., Mulligan, R. C., Osawa, H., Diamantstein, T., Yokoyama, S., and Taniguchi, T.　EMBO JOURNAL　6　6　2705-2709　1987/09
  • 　Recombination of two homologous MHC class III genes of the mouse (C4 and Slp) that accounts for the loss of testosterone dependence of sex-limited protein expression.　Nakayama, K., Nonaka, M., Yokoyama, S., Yu, D. Y., Pattanakitsakul, S-N., and Takahashi, M.　JOURNAL OF IMMUNOLOGY　138　2　620-627　1987/01
  • 　Identification of 5'-flanking regulatory region responsible for the difference in transcriptional control between mouse C4 and Slp genes.　Nonaka, M., Kimura, H., Yu, D. Y., Yokoyama, S., Nakayama, K., and Takahashi, M.　PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AME　83　7883-7887　1986/10

Conference Presentations

Others

  • 　Expression of interleukin-6 mRNA at the dorsal root ganglia -gradual nerve elongation model-.　Osamura, N., Ikeda, K., Hagiwara, N., Hinoki, S., Tomita, K., Yokoyama, S., and Higashida, H.　pp　 59-62　2003
  • 　Cell membrane blebbing is related to the CD38 redistribution in NG108-15 hybrid cells.　Egorova, A. B., Yokoyama, S., Fukami, H., and Higashida, H.　Plenum Publishing　32　3　275-276　2000/06

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「損傷神経に誘導される新規蛋白がイオンチャネル活動調節・痛み情報伝達に果たす役割」(2009-2011)　
○「電位依存性ナトリウム・カリウムチャネルの神経障害性疼痛に伴う発現異常の分子機構」(1999-)　
○「一次求心性Ａβ線維のイオンチャネル発現調節機構の解明と難治性疼痛治療への応用」(2006-2007)　
○「一次求心性Ａβ線維のイオンチャネル発現異常が神経障害性疼痛発生に与える影響」(2003-2005)　
○「ドーパミン受容体系とカップルするADPリボース環状化酵素：パーキンソン脳への応用」(2003-)　
○「Ａキナーゼアンカータンパク（AKAP）依存的シナプス後電位：終止の分子メカニズム」(2005-)　
○「ラット新生仔脳及びCD38ノックアウトマウス脳のDPリボシールシクラーゼの精製」(2005-)　
○「社会認識に関わる分子の神経化学的解析による自閉症の解明と治療」(2007-)　
○「細胞外サイクリックADPリボースのセンサー機構」(2007-)　
○「膜電位依存性Ｋ＋チャネルに会合する調節蛋白のcDNAクローニング」(1997-)　
○「膜電位依存性カリウムＭチャネルの遺伝子クローニング」(1997-)　
○「小脳由来の不活性化しないカリウムチャネルの分子機構」(1997-)　
○「脳型ADPリボシールシクラーゼの精製と遺伝子クローニング」(1997-)　
○「ラスがん遺伝子とイノシトール四リン酸で駆動されるCa2+流入チャネルとの機能相関」(1998-)　
○「電位依存性カリウムＭチャネルの受容体による制御機構の解明」(2000-)　
○「受容体とカップルするADPリボシールシクラーゼ分子の個体レベルでの解析」(2000-)　
○「神経損傷誘導性糖蛋白Gpnmbがイオンチャネル活動調節・痛み情報伝達に果たす役割」(2012-2014)　

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

Classes (Graduate Schools)

International Project

International Students

Lecture themes

Others (Social Activities)

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