Professor KURACHI, Makoto
Faculty, Affiliation
Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences
College and School Educational Field
Division of Medical Sciences, Graduate School of Medical Science
Graduate School of Advanced Preventive Medical Sciences
Division of Medicine, Graduate School of Medical Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences
School of Medicine, College of Medical, Pharmaceutical and Health Sciences
School of Medicine, College of Medical, Pharmaceutical and Health Sciences
Laboratory
Department of Molecular Genetics, Graduate School of Medicine, Kanazawa University TEL:076-265-2176 FAX:076-234-4225
Academic Background
【Academic background(Doctoral/Master's Degree)】
Kanazawa University Doctor Graduate School of Medicine Internal Medicine 200203 Completed
【Academic background(Bachelor's Degree)】
Kanazawa University 199703
【Degree】
M.D., PhD.
Career
Kanazawa University University Hospital Resident (Internal Medicine)(1997/04-1998/03)
Kurobe City Hospital Resident(1998/04-1999/03)
Kanazawa University University Hospital Medical Staff(1999/04-2000/03)
JST Research staff(2002/04-2004/05)
University of Tokyo Graduate School of Medicine Staff(2004/06-2006/11)
University of Tokyo Graduate School of Medicine Assistant Professor(2006/12-2011/08)
University of Pennsylvania School of Medicine Post doctoral fellow(2011/09-2016/08)
University of Pennsylvania School of Medicine Research Associate(2016/09-2018/08)
Kanazawa University Graduate School of Medicine Professor(2018/09-)
Year & Month of Birth
1973/03
Academic Society
Japanese Society for Immunology
Award
Specialities
Pathological medical chemistry、Immunology、General medical chemistry
Speciality Keywords
Immune response to infection, T lymphocytes, Immunologic memory, Inflammation, Virus infection, cell differentiation, Transcription factor
Research Themes
CD8 T cell differentiation (effector, memory, exhaustion)
Books
Papers
- CD8+ T cell exhaustion. Makoto Kurachi Seminars in immunopathology 41 3 327 2019/05
- Hidden Caveat of Inducible Cre Recombinase. Makoto Kurachi,Shin Foong Ngiow,Junko Kurachi,Zeyu Chen,E John Wherry Immunity 51 4 591 2019/10/15
- Chemokine receptor CXCR3 facilitates CD8(+) T cell differentiation into short-lived effector cells leading to memory degeneration Makoto Kurachi,Junko Kurachi,Fumiko Suenaga,Tatsuya Tsukui,Jun Abe,Satoshi Ueha,Michio Tomura,Kei Sugihara,Shiki Takamura,Kazuhiro Kakimi,Kouji Matsushima JOURNAL OF EXPERIMENTAL MEDICINE 208 8 1605 2011/08
- The transcription factor BATF operates as an essential differentiation checkpoint in early effector CD8(+) T cells Makoto Kurachi,R. Anthony Barnitz,Nir Yosef,Pamela M. Odorizzi,Michael A. DiIorio,Madeleine E. Lemieux,Kathleen Yates,Jernej Godec,Martin G. Klatt,Aviv Regev,E. John Wherry,W. Nicholas Haining NATURE IMMUNOLOGY 15 4 373 2014/04
- Optimized retroviral transduction of mouse T cells for in vivo assessment of gene function Makoto Kurachi,Junko Kurachi,Zeyu Chen,John Johnson,Omar Khan,Bertram Bengsch,Erietta Stelekati,John Attanasio,Laura M. McLane,Michio Tomura,Satoshi Ueha,E. John Wherry NATURE PROTOCOLS 12 9 1980 2017/09
- Developmental Relationships of Four Exhausted CD8+ T Cell Subsets Reveals Underlying Transcriptional and Epigenetic Landscape Control Mechanisms. Jean-Christophe Beltra,Sasikanth Manne,Mohamed S Abdel-Hakeem,Makoto Kurachi,Josephine R Giles,Zeyu Chen,Valentina Casella,Shin Foong Ngiow,Omar Khan,Yinghui Jane Huang,Patrick Yan,Kito Nzingha,Wei Xu,Ravi K Amaravadi,Xiaowei Xu,Giorgos C Karakousis,Tara C Mitchell,Lynn M Schuchter,Alexander C Huang,E John Wherry Immunity 52 5 825 2020/05/19
- In vivo CD8+ T cell CRISPR screening reveals control by Fli1 in infection and cancer. Zeyu Chen,Eri Arai,Omar Khan,Zhen Zhang,Shin Foong Ngiow,Yuan He,Hua Huang,Sasikanth Manne,Zhendong Cao,Amy E Baxter,Zhangying Cai,Elizabeth Freilich,Mohammed A Ali,Josephine R Giles,Jennifer E Wu,Allison R Greenplate,Mohamed A Hakeem,Qingzhou Chen,Makoto Kurachi,Kito Nzingha,Viktoriya Ekshyyan,Divij Mathew,Zhuoyu Wen,Nancy A Speck,Alexis Battle,Shelley L Berger,E John Wherry,Junwei Shi Cell 184 5 1262 2021/03/04
Conference Presentations
Others
Arts and Fieldwork
Patent
Theme to the desired joint research
○Epigenetic modification and cell differentiation by transcription factors
Grant-in-Aid for Scientific Research
○「T細胞疲弊における転写因子制御とクロマチンランドスケープ連関の解明と応用」(2022-2024)
○「パイオニア転写因子BATF-IRF4複合体が制御するCTL分化機序の解明」(2019-2022)
○「肝炎ウイルス特異的T細胞に対する免疫制御機構に関する研究」(2005-2006)
○「ケモカイン受容体CXCR3によるメモリーCTL樹立・維持の制御機構の解明」(2010-2011)
○「反復感染応答におけるメモリーCD8陽性T細胞集団の老化と維持機構に関する研究」(2008-2009)
Competitive research funding,Contribution
○Formation of international research center for immunological memory Sakigake Kanazawa University(2022-2023)
Collaborative research,Consignment study
Classes (Bachelors)
○Basic Medical and Pharmaceutical Sciences Rotation Practice（Course in Biomedical Science）ⅠＡ(2023)
○Biochemistry 1(2023)
○Basic Medical and Pharmaceutical Sciences Rotation Practice（Course in Biomedical Science）ⅠＡ(2023)
○Biochemistry 3(2023)
○Bioinformatics 2(2023)
○Basic Health Science 1(2023)
○Introduction to Region-studies(2023)