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last modified：2025/08/11
Associate Professor Karashima Shigehiro
Faculty, Affiliation
Institute of Liberal Arts and Science
College and School Educational Field
Graduate School of Frontier Science Initiative
Division of Medical Sciences, Graduate School of Medical Science
Division of Medicine, Graduate School of Medical Science
Faculty of Global Standard Education, Institute of Liberal Arts and Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences
Laboratory
Academic Background
Career
Year & Month of Birth
Academic Society
THE JAPANESE SOCIETY OF INTERNAL MEDICINE
The Japan Endocrine Society
THE MASS SPECTROMETRY SOCIETY OF JAPAN
THE JAPAN DIABETES SOCIETY
The Japanese Circulation Society
JAPAN SOCIETY FOR THE STUDY OF OBESITY
Award
Specialities
Epidemiology and preventive medicine、Metabolomics、Endocrinology
Speciality Keywords
Research Themes
The relationship between steroid hormone and life style diseases
Books
Papers
- Raised aldosterone benin ratio predicts aldosterone breakthrough phenomenonin hypetensive patients treated with angiotensin-II receptor blocker Takashi Yoneda,Yoshiyu Takeda,Mikiya Usukura,Hiroyuki Takada,Shigehiro Karashima,Tomoko Sakai,Masakazu Yamagishi JOURNAL OF HYPERTENSION 24 228 2006/12
- Effect of telmisartan on insulin resistance in hypertensive patients with obesity Takashi Yoneda,Yoshiyu Takeda,Mikiya Usukura,Hiroyuki Takada,Shigehiro Karashima,Tomoko Sakai,Masakazu Yamagishi JOURNAL OF HYPERTENSION 24 296 2006/12
- Raised aldosterone to renin ratio predicts increased rate of cardiovascular and renal events in patients with essential hypertension. Hiroyuki takata,Yoshiyu Takeda,Takashi Yoneda,Mikiya Usukura,Shigehiro Karashima,Satoko Sakai,Aoshuang Zhu JOURNAL OF HYPERTENSION 24 302 2006/12
- Effect of eplerenone, a selective aldosterone blocker, on adiposal renin-angiotensin-aldosterone system in saltsensitive hypertensive rats Aoshuang Zhu,Yoshiyu Takeda,Mikiya Usukura,Takashi Yoneda,Hiroyuki Takata,Shigehiro Karashima,Satoko Sakai,Masakazu Yamagishi JOURNAL OF HYPERTENSION 24 312 2006/12
- Effects of candesartan and eplerenone on cardiac renin-angiotensin-aldosteroen system in experimental salt-sensitive hypertension Yoshiyu Takeda,Aoshuang Zhu,Takashi Yoneda,Mikiya Usukura,Hiroyuki Takata,Shigehiro Karashima,Satoko Sakai,Masakazu Yamagishi JOURNAL OF HYPERTENSION 24 312 2006/12
- Aldosterone breakthrough during angiotensin II receptor blockade in hypertensive patients with diabetes mellitus Takashi Yoneda,Yoshiyu Takeda,Mikiya Usukura,Nobushige Oda,Hiroyuki Takata,Yasuhiro Yamamoto,Shigehiro Karashima,Masakaz Yamagishi AMERICAN JOURNAL OF HYPERTENSION 20 12 1329 2007/12
- Effect of mineralocorticoid receptor blockade on the renal renin-angiotensin system in Dahl salt-sensitive hypertensive rats Aoshuang Zhu,Takashi Yoneda,Masashi Demura,Shigehiro Karashima,Mikiya Usukura,Masakazu Yamagishi,Yoshiyu Takeda JOURNAL OF HYPERTENSION 27 4 800 2009/04
- A possible new syndrome with double endocrine tumors in association with an unprecedented type of familial heart-hand syndrome: A Case report Masashi Demura,Takashi Yoneda,Shigehiro Karashima,Toshinori Higashikata,Hiroshi Mabuchi,Mitsuhiro Kawano,Masakazu Yamagishi,Yoshiyu Takeda Journal of Medical Case Reports 4 1 347 2010
- Epigenetic transcriptional repression of the human CYP11B2 gene Masashi Demura,Fen Wang,Takashi Yoneda,Shigehiro Karashima,Yuan Cheng,Masakazu Yamagishi,Yoshiyu Takeda ENDOCRINE JOURNAL 57 S339 2010/03
- Effects of the blockade of angiotensin II and aldosterone on the experimental diabetic neuropathy Yoshiyu Takeda,Hiroyuki Takata,Shigehiro Karashima,Mitsuhiro Kometani,Masashi Ohe,Masashi Demura,Shunsuke Mori,Yuan Cheng,Takashi Yoneda ENDOCRINE JOURNAL 57 S646 2010/03
- Ectopic Production of Parathyroid Hormone in a Patient with Sporadic Medullary Thyroid Cancer Masashi Demura,Takashi Yoneda,Fen Wang,Yoh Zen,Shigehiro Karashima,Aoshuang Zhu,Yuan Cheng,Masakazu Yamagishi,Yoshiyu Takeda ENDOCRINE JOURNAL 57 2 161 2010/02
- Aldosterone breakthrough during combination therapy with angiotensin II receptor blocker and low dose diuretic in hypertensive patients with diabetes mellitus Takashi Yoneda,Yoshiyu Takeda,Shigehiro Karashima,Masashi Demura,Mikiya Usukura,Hiroyuki Takata,Nobushige Oda,Yasuhiro Yamamoto,Atsushi Hashimoto,Shunsuke Mori,Mitsuhiro Kometani,Masashi Ooe,Masakazu Yamagishi ENDOCRINE JOURNAL 57 S552 2010/03
- Alcohol-induced big ACTH production in a patient with pseudo-Cushing's syndrome Shigehiro Karashima,Toshitaka Sawamura,Masashi Ohe,Mitsuhiro Kometani,Masashi Demura,Shunsuke Mori,Takashi Yoneda,Yoshiyu Takeda ENDOCRINE JOURNAL 57 S514 2010/03
- Effect of eplerenone, a selective aldosterone blocker, on severe hypokalemia in a patient with big IGFII-producing non-islet cell tumor Shigehiro Karashima,Mitsuhiro Kometani,Masashi Ohe,Masashi Demura,Shunsuke Mori,Takashi Yoneda,Yoshiyu Takeda ENDOCRINE JOURNAL 57 S593 2010/03
- Serotonin receptor in aldosterone producing adenoma : Implication for aldosterone secretion Isamu Miyamori,Miki Fujii,Satoru Inaba,Isao Inoki,Tadashi Konoshita,Yoshiyu Takeda,Takashi Yoneda,Shigehiro Karashima ENDOCRINE JOURNAL 57 S637 2010/03
- Aldosterone blockade improves visceral fat area in patients with primary aldosteronism Shigehiro Karashima,Masashi Ohe,Mitsuhiro Kometani,Masashi Demura,Shunsuke Mori,Yasuhiro Yamamoto,Takashi Yoneda,Yoshiyu Takeda ENDOCRINE JOURNAL 57 S646 2010/03
- Prevalence of primary aldosteronism among prehypertensive and stage 1 hypertensive subjects Yuji Ito,Ryoyu Takeda,Shigehiro Karashima,Yasuhiro Yamamoto,Takashi Yoneda,Yoshiyu Takeda HYPERTENSION RESEARCH 34 1 98 2011/01
- Effects of a high-salt diet on adipocyte glucocorticoid receptor and 11-beta hydroxysteroid dehydrogenase 1 in salt-sensitive hypertensive rats Mikiya Usukura,Aoshuang Zhu,Takashi Yoneda,Shigehiro Karashima,Kunimasa Yagi,Masakazu Yamagishi,Yoshiyu Takeda STEROIDS 74 12 978 2009/11
- Effects of eplerenone, a selective aldosterone blocker, on blood pressure and organ damage in adrenalectomized hypertensive rats Yoshiyu Takeda,Aoshuang Zhu,Takashi Yoneda,Mikiya Usukura,Hiroyuki Takata,Shigehiro Karashima,Satoko Sakai,Masakazu Yamagishi JOURNAL OF HYPERTENSION 24 85 2006/12
- Effects of high sodium diet on adiposal renin-angiotensin-aldosterone system in stroke-prone spontaneously hypertensive rats Mikiya Usukura,Yoshiyu Takeda,Aoshuang Zhu,Takashi Yoneda,Hiroyuki Takata,Shigehiro Karashima,Satoko Sakai,Masakazu Yamagishi JOURNAL OF HYPERTENSION 24 157 2006/12
- The Long-term Effect of Adrenal Arterial Embolization for Unilateral Primary Aldosteronism on Cardiorenovascular Protection, Blood Pressure, and the Endocrinological Profile Mitsuhiro Kometani,Takashi Yoneda,Masashi Demura,Shigehiro Karashima,Shunsuke Mori,Masashi Oe,Toshitaka Sawamura,Rika Okuda,Masakazu Yamagishi,Yoshiyu Takeda INTERNAL MEDICINE 55 7 769 2016
- Unilateral Primary Aldosteronism with Spontaneous Remission after Long-Term Spironolactone Therapy Takashi Yoneda,Masashi Demura,Hiroyuki Takata,Mitsuhiro Kometani,Shigehiro Karashima,Masakazu Yamagishi,Yoshiyu Takeda JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 97 4 1109 2012/04
- Primary aldosteronism, diagnosis and treatment in Japan Yoshiyu Takeda,Shigehoro Karashima,Takashi Yoneda Reviews in Endocrine and Metabolic Disorders 12 1 21 2011/03
- Clinical characteristics of primary hyperaldosteronism due to adrenal microadenoma Shigehiro Karashima,Yoshiyu Takeda,Yuan Cheng,Takashi Yoneda,Masashi Demura,Mitsuhiro Kometani,Masashi Ohe,Shunsuke Mori,Kunimasa Yagi,Masakazu Yamagishi STEROIDS 76 12 1363 2011/11
- Protective effects of mineralocorticoid receptor blockade against neuropathy in experimental diabetic rats H. Takata,Y. Takeda,A. Zhu,Y. Cheng,T. Yoneda,M. Demura,K. Yagi,S. Karashima,M. Yamagishi DIABETES OBESITY & METABOLISM 14 2 155 2012/02
- Severe Mitral Regurgitation As a Result of Rupture of Mitral Valve Chordae Tendineae in a Patient With Graves Disease Shigehiro Karashima,Toyonobu Tsuda,Mitsuhiro Kometani,Rie Oka,Masashi Demura,Masa-aki Kawashiri,Yoshiyu Takeda,Kenshi Hayashi,Takashi Yoneda Journal of the Endocrine Society 2 11 1246 2018/11/01
? - Ventricular Fibrillation Associated With Dynamic Changes in J-Point Elevation in a Patient With Silent Thyroiditis Shigehiro Karashima,Toyonobu Tsuda,Yusuke Wakabayashi,Mitsuhiro Kometani,Masashi Demura,Taro Ichise,Masa-aki Kawashiri,Yoshiyu Takeda,Kenshi Hayashi,Takashi Yoneda Journal of the Endocrine Society 2 2 135 2018/02/01 ?
- Insulin Secretion and Risk for Future Diabetes in Subjects with a Nonpositive Insulinogenic Index. Daisuke Aono,Rie Oka,Mitsuhiro Kometani,Yoshimichi Takeda,Shigehiro Karashima,Kenichi Yoshimura,Yoshiyu Takeda,Takashi Yoneda Journal of diabetes research 2018 5107589 2018
- The status of glycemic control and hypoglycemia in elderly patients visiting the outpatient department specializing in diabetes Yui Soma,Rie Oka,Sumie Fujii,Naoko Ito,Mitsuhiro Kometani,Shigehiro Karashima,Yoshiyu Takeda,Takashi Yoneda,Akimichi Asano Japanese Journal of Geriatrics 55 2 268 2018
- Age-dependent Increases in Adrenal Cytochrome b5 and Serum 5-Androstenediol-3-sulfate Juilee Rege,Shigehiro Karashima,Antonio M. Lerario,Joshua M. Smith,Richard J. Auchus,Josephine Z. Kasa-Vubu,Hironobu Sasano,Yasuhiro Nakamura,Perrin C. White,William E. Rainey JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 101 12 4585 2016/12
- Impact of New Quick Gold Nanoparticle-Based Cortisol Assay During Adrenal Vein Sampling for Primary Aldosteronism Takashi Yoneda,Shigehiro Karashima,Mitsuhiro Kometani,Mikiya Usukura,Masashi Demura,Junichirou Sanada,Tetsuya Minami,Wataru Koda,Toshifumi Gabata,Osamu Matsui,Koutarou Idegami,Yuzuru Takamura,Eiichi Tamiya,Masashi Oe,Masuo Nakai,Shunsuke Mori,Noboru Terayama,Yuichi Matsuda,Kouhei Kamemura,Sumie Fujii,Takashi Seta,Toshitaka Sawamura,Rika Okuda,Yoshimichi Takeda,Kenshi Hayashi,Masakazu Yamagishi,Yoshiyu Takeda JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM 101 6 2554 2016/06
- double dagger@ Epigenetic Controls of CYP11B2 and CYP11B1 Gene in Subclinical Cushing Syndrome Associated with Overproduction of Aldosterone Mitsuhiro Kometani,Masashi Demura,Takashi Yoneda,Shigehiro Karashima,Masashi Oe,Yoshiyu Takeda ENDOCRINE REVIEWS 35 3 2014/06
- Steroidogenic Enzyme Gene Expression in the Pheochromocytoma Shigehiro Karashima,Takashi Yoneda,Masashi Demura,Mitsuhiro Kometani,Masashi Ohe,Yoshiyu Takeda ENDOCRINE REVIEWS 35 3 2014/06
- Epigenetic Control of 11 beta-Hydroxysteroid Dehydrogenase 1 in the Adipose Tissue of Cushing's Syndrome Yoshiyu Takeda,Takashi Yoneda,Masashi Demura,Shigehiro Karashima,Mitsuhiro Kometani,Fen Wang,Yuan Cheng,Masashi Ohe ENDOCRINE REVIEWS 35 3 2014/06
- A Case of Multiple Aldosterone-Producing Microadenomas with Different Mutations in KCNJ5 Gene Eriko Kabata,Mitsuhiro Kometani,Masashi Oe,Shigehiro Karashima,Masashi Demura,Takashi Yoneda,Yoshiyu Takeda ENDOCRINE REVIEWS 35 3 2014/06
- Diagnostic Discrepancy Between Adrenal Vein Sampling with and without ACTH Stimulation in Surgically-Curable Primary Aldosteronism Associated with KCNJ5 Somatic Mutation Takashi Yoneda,Mitsuhiro Kometani,Masashi Demura,Shigehiro Karashima,Masashi Oe,Toshitaka Sawamura,Mitsugu Yoneda,Masakazu Yamagishi,Yoshiyu Takeda ENDOCRINE REVIEWS 35 3 2014/06
- A Case of Aldosterone-Producing Microadenoma with KCNJ5 Mutation Masashi Oe,Mitsuhiro Kometani,Shigehiro Karashima,Masashi Demura,Takashi Yoneda,Yoshiyu Takeda ENDOCRINE REVIEWS 35 3 2014/06
- Dynamic CCAAT/Enhancer Binding Protein-Associated Changes of DNA Methylation in the Angiotensinogen Gene Fen Wang,Masashi Demura,Yuan Cheng,Aoshuang Zhu,Shigehiro Karashima,Takashi Yoneda,Yoshiki Demura,Yuji Maeda,Mikio Namiki,Katsuhiko Ono,Yasuhiro Nakamura,Hironobu Sasano,Tadayuki Akagi,Masakazu Yamagishi,Kiyofumi Saijoh,Yoshiyu Takeda HYPERTENSION 63 2 281 2014/02
- Multiple noncoding exons 1 of nuclear receptors NR4A family (nerve growth factor-induced clone B, Nur-related factor 1 and neuron-derived orphan receptor 1) and NR5A1 (steroidogenic factor 1) in human cardiovascular and adrenal tissues Masashi Demura,Fen Wang,Takashi Yoneda,Shigehiro Karashima,Shunsuke Mori,Masashi Oe,Mitsuhiro Kometani,Toshitaka Sawamura,Yuan Cheng,Yuji Maeda,Mikio Namiki,Hidekazu Ino,Noboru Fujino,Katsuharu Uchiyama,Toshinari Tsubokawa,Masakazu Yamagishi,Yasuhiro Nakamura,Katsuhiko Ono,Hironobu Sasano,Yoshiki Demura,Yoshiyu Takeda JOURNAL OF HYPERTENSION 29 6 1185 2011/06
- Angiotensin II receptor blocker combined with eplerenone or hydrochlorothiazide for hypertensive patients with diabetes mellitus Shigehiro Karashima,Takashi Yoneda,Mitsuhiro Kometani,Masashi Ohe,Shunsuke Mori,Toshitaka Sawamura,Kenji Furukawa,Masakazu Yamagishi,Yoshiyu Takeda CLINICAL AND EXPERIMENTAL HYPERTENSION 38 7 565 2016
- Impact of aldosterone-producing cell clusters on diagnostic discrepancies in primary aldosteronism. Mitsuhiro Kometani,Takashi Yoneda,Daisuke Aono,Shigehiro Karashima,Masashi Demura,Koshiro Nishimoto,Masakazu Yamagishi,Yoshiyu Takeda Oncotarget 9 40 26007 2018/05/25
- Epigenetic Regulation of Aldosterone Synthase Gene by Sodium and Angiotensin II. Yoshimichi Takeda,Masashi Demura,Fen Wang,Shigehiro Karashima,Takashi Yoneda,Mitsuhiro Kometani,Atsushi Hashimoto,Daisuke Aono,Shin-Ichi Horike,Makiko Meguro-Horike,Masakazu Yamagishi,Yoshiyu Takeda Journal of the American Heart Association 7 10 2018/05/08
- Prevalence of primary aldosteronism without hypertension in the general population: Results in Shika study. Shigehiro Karashima,Mitsuhiro Kometani,Hiromasa Tsujiguchi,Hiroki Asakura,Shigeru Nakano,Mikiya Usukura,Shunsuke Mori,Masashi Ohe,Toshitaka Sawamura,Rika Okuda,Akinori Hara,Toshinari Takamura,Masakazu Yamagishi,Hiroyuki Nakamura,Yoshiyu Takeda,Takashi Yoneda Clinical and experimental hypertension (New York, N.Y. : 1993) 40 2 118 2018
- Effect of sodium glucose cotransporter 2 inhibitors on obstructive sleep apnea in patients with type 2 diabetes Kei Sawada,Shigehiro Karashima,Mitsuhiro Kometani,Rie Oka,Yoshimichi Takeda,Toshitaka Sawamura,Aya Fujimoto,Masashi Demura,Ayako Wakayama,Mikiya Usukura,Kunimasa Yagi,Yoshiyu Takeda,Takashi Yoneda Endocrine Journal 65 4 461 2018
- Associations between Sleep-Disordered Breathing and Metabolic Risk Factors beyond Obesity. Wakabayashi Y,Oka R,Nakaya M,Karashima S,Kometani M,Sakurai M,Yoshimura K,Yoneda T Journal of diabetes research 2018 1567683 2018
- Cortisol overproduction results from DNA methylation of CYP11B1 in hypercortisolemia Mitsuhiro Kometani,Takashi Yoneda,Masashi Demura,Hiroshi Koide,Koshiro Nishimoto,Kuniaki Mukai,Celso E. Gomez-Sanchez,Tadayuki Akagi,Takashi Yokota,Shin-ichi Horike,Shigehiro Karashima,Isamu Miyamori,Masakazu Yamagishi,Yoshiyu Takeda SCIENTIFIC REPORTS 7 1 11205 2017/09
- A Novel Method: Super-selective Adrenal Venous Sampling Kohzoh Makita,Koshiro Nishimoto,Kanako Kiriyama-Kitamoto,Shigehiro Karashima,Tsugio Seki,Masanori Yasuda,Seishi Matsui,Masao Omura,Tetsuo Nishikawa JOVE-JOURNAL OF VISUALIZED EXPERIMENTS 127 2017/09
- Mutated KCNJ5 activates the acute and chronic regulatory steps in aldosterone production Namita G. Hattangady,Shigehiro Karashima,Lucy Yuan,Daniela Ponce-Balbuena,Jose Jalife,Celso E. Gomez-Sanchez,Richard J. Auchus,William E. Rainey,Tobias Else JOURNAL OF MOLECULAR ENDOCRINOLOGY 57 1 1 2016/07
- Comparison of eplerenone and spironolactone for the treatment of primary aldosteronism Shigehiro Karashima,Takashi Yoneda,Mitsuhiro Kometani,Masashi Ohe,Shunsuke Mori,Toshitaka Sawamura,Kenji Furukawa,Takashi Seta,Masakazu Yamagishi,Yoshiyu Takeda HYPERTENSION RESEARCH 39 3 133 2016/03
- Madelung disease in a 58-year-old man. Karashima S,Yoneda T CMAJ : Canadian Medical Association journal = journal de l'Association medicale canadienne 191 2 E48 2019/01
- Pheochromocytoma crisis with cyclic fluctuation in blood pressure mimics acute coronary syndrome Mitsuhiro Kometani,Takashi Yoneda,Yuji Maeda,Masashi Oe,Yoshimichi Takeda,Takuya Higashitani,Daisuke Aono,Asuka Yoshino,Shigehiro Karashima,Yoshiyu Takeda Endocrinology, Diabetes & Metabolism Case Reports 2020 2020/09/23
- Feasibility of a Novel Mobile C-Reactive Protein–Testing Device Using Gold-Linked Electrochemical Immunoassay: Clinical Performance Study Yuko Gondoh-Noda,Mitsuhiro Kometani,Akihiro Nomura,Daisuke Aono,Shigehiro Karashima,Hiromi Ushijima,Eiichi Tamiya,Toshinori Murayama,Takashi Yoneda JMIR mHealth and uHealth 8 9 e18782 2020/09/07
- A case of renovascular hypertension with incidental primary bilateral macronodular adrenocortical hyperplasia Takuya Higashitani,Shigehiro Karashima,Daisuke Aono,Seigoh Konishi,Mitsuhiro Kometani,Rie Oka,Masashi Demura,Kenji Furukawa,Yuto Yamazaki,Hironobu Sasano,Takashi Yoneda,Yoshiyu Takeda Endocrinology, Diabetes & Metabolism Case Reports 2020 1 1 2020/08/06
- Impact of mineralocorticoid receptor blockade with direct renin inhibition in angiotensin II-dependent hypertensive mice Atsushi Hashimoto,Yoshimichi Takeda,Shigehiro Karashima,Mitsuhiro Kometani,Daisuke Aono,Masashi Demura,Takuya Higashitani,Seigo Konishi,Takashi Yoneda,Yoshiyu Takeda Hypertension Research 43 10 1099 2020/05
- Genetic and epigenetic analyses of aldosterone-producing adenoma with hypercortisolemia Mitsuhiro Kometani,Takashi Yoneda,Masashi Demura,Daisuke Aono,Yuko Gondoh,Shigehiro Karashima,Koshiro Nishimoto,Masanori Yasuda,Shin-ichi Horike,Yoshiyu Takeda Steroids 151 108470 2019/11
- Impact of Gut Microbiome on Hypertensive Patients With Low-Salt Intake: Shika Study Results Satoshi Nagase,Shigehiro Karashima,Hiromasa Tsujiguchi,Hirohito Tsuboi,Sakae Miyagi,Mitsuhiro Kometani,Daisuke Aono,Takuya Higashitani,Masashi Demura,Hiroyuki Sakakibara,Akihiro Yoshida,Akinori Hara,Hiroyuki Nakamura,Yoshiyu Takeda,Hidetaka Nambo,Takashi Yoneda,Shigefumi Okamoto Frontiers in Medicine 7 475 2020/09/02
- Effect of sodium–glucose cotransporter-2 inhibitors on aldosterone-to-renin ratio in diabetic patients with hypertension: a retrospective observational study Toshitaka Sawamura,Shigehiro Karashima,Satoshi Nagase,Hidetaka Nambo,Eiko Shimizu,Takuya Higashitani,Daisuke Aono,Azusa Ohbatake,Mitsuhiro Kometani,Masashi Demura,Kenji Furukawa,Yoshiyu Takeda,Takashi Yoneda BMC Endocrine Disorders 20 1 177 2020/12
- Primary aldosteronism subtype discordance between computed tomography and adrenal venous sampling Daisuke Aono,Mitsuhiro Kometani,Shigehiro Karashima,Mikiya Usukura,Yuko Gondo,Atsushi Hashimoto,Masashi Demura,Kenji Furukawa,Yoshiyu Takeda,Masaaki Kawashiri,Takashi Yoneda Hypertension Research 42 12 1942 2019/12
- C-Peptide Area Under the Curve at Glucagon Stimulation Test Predicts Glucose Improvements by GLP-1 Receptor Analogue: A Retrospective Observational Study Azusa Ohbatake,Kunimasa Yagi,Shigehiro Karashima,Yuki Shima,Yukiko Miyamoto,Hiroyuki Asaka,Satoko Okazaki,Mitsuhiro Kometani,Masa-aki Kawashiri,Yoshiyu Takeda,Takashi Yoneda,Daisuke Chujo Diabetes Therapy 10 2 673 2019/04 ?
- Renal Artery Aneurysm Due to Fenestration of a Branch of the Renal Artery: A Case Study Shigehiro Karashima,Mitsuhiro Kometani,Daisuke Aono,Takuya Higashitani,Yuya Nishimoto,Seigoh Konishi,Masashi Demura,Yoshiyu Takeda,Takashi Yoneda Journal of the Endocrine Society 5 2 2021/02/01 ?
- Primary Aldosteronism with Parathyroid Hormone Elevation: A Single-center Retrospective Study. Mitsuhiro Kometani,Takashi Yoneda,Daisuke Aono,Yuko Gondoh-Noda,Takahiro Matsuoka,Takuya Higashitani,Shohei Yoshikura,Kei Sawada,Yoshimichi Takeda,Aya Fujimoto,Shigehiro Karashima,Mikiya Usukura,Yoshiyu Takeda Internal medicine (Tokyo, Japan) 60 7 993 2021
- Penile and scrotal oedema along with urinary retention after insulin therapy. Yoshimichi Takeda,Shigehiro Karashima,Mitsuhiro Kometani,Takashi Yoneda BMJ case reports 14 7 2021/07/22
- Effect of potassium on DNA methylation of aldosterone synthase gene. Yoshimichi Takeda,Masashi Demura,Fen Wang,Shigehiro Karashima,Takashi Yoneda,Mitsuhiro Kometani,Daisuke Aomo,Atsushi Hashimoto,Shin-Ichi Horike,Makiko Meguro-Horike,Yoshiyu Takeda Journal of hypertension 39 5 1018 2021/05/01
- Carcinoma of unknown primary origin with isolated adrenal metastasis: a report of two cases. Mitsuhiro Kometani,Takashi Yoneda,Yuji Maeda,Koushiro Ohtsubo,Yuto Yamazaki,Hiroko Ikeda,Shunsuke Mori,Daisuke Aono,Shigehiro Karashima,Mikiya Usukura,Hironobu Sasano,Yoshiyu Takeda Endocrine journal 68 10 1209 2021/10/28
- Impact of salt intake on urinary albumin excretion in patients with type 2 diabetic nephropathy: a retrospective cohort study based on a generalized additive model. Yuka Kotake,Shigehiro Karashima,Masaki Kawakami,Satoshi Hara,Daisuke Aono,Seigo Konishi,Mitsuhiro Kometani,Hiroyuki Mori,Yoshiyu Takeda,Takashi Yoneda,Hidetaka Nambo,Kenji Furukawa Endocrine journal 69 5 577 2021/12/22
- Explainable Machine Learning for Atrial Fibrillation in the General Population Using a Generalized Additive Model - A Cross-Sectional Study. Masaki Kawakami,Shigehiro Karashima,Kento Morita,Hayato Tada,Hirofumi Okada,Daisuke Aono,Mitsuhiro Kometani,Akihiro Nomura,Masashi Demura,Kenji Furukawa,Takashi Yoneda,Hidetaka Nambo,Masa-Aki Kawashiri Circulation reports 4 2 73 2022/02/10
- Rapidity and Precision of Steroid Hormone Measurement. Shigehiro Karashima,Issey Osaka Journal of clinical medicine 11 4 2022/02/12
- Remitting Seronegative Symmetrical Synovitis with Pitting Edema Syndrome Worsen after the Administration of Dulaglutide. Toshitaka Sawamura,Shigehiro Karashima,Ai Ohmori,Kei Sawada,Mitsuhiro Kometani,Yoshiyu Takeda,Takashi Yoneda Medicina (Kaunas, Lithuania) 58 2 2022/02/14
- Evaluating tubulointerstitial compartments in renal biopsy specimens using a deep learning-based approach for classifying normal and abnormal tubules. Satoshi Hara,Emi Haneda,Masaki Kawakami,Kento Morita,Ryo Nishioka,Takeshi Zoshima,Mitsuhiro Kometani,Takashi Yoneda,Mitsuhiro Kawano,Shigehiro Karashima,Hidetaka Nambo PloS one 17 7 e0271161 2022
- Impact of gut microbiome on dyslipidemia in japanese adults: Assessment of the Shika-machi super preventive health examination results for causal inference. Yuna Miyajima,Shigehiro Karashima,Kazuhiro Ogai,Kouki Taniguchi,Kohei Ogura,Masaki Kawakami,Hidetaka Nambo,Mitsuhiro Kometani,Daisuke Aono,Masashi Demura,Takashi Yoneda,Hiromasa Tsujiguchi,Akinori Hara,Hiroyuki Nakamura,Shigefumi Okamoto Frontiers in cellular and infection microbiology 12 908997 2022
- Comprehensive Steroid Assay with Non-Targeted Analysis Using Liquid Chromatography Ion Mobility Mass Spectrometry Mai Yamakawa,Shigehiro Karashima,Riko Takata,Taichi Haba,Keigo Kuroiwa,Hideaki Touyama,Atsushi Hashimoto,Seigo Konishi,Daisuke Aono,Mitsuhiro Kometani,Hidetaka Nambo,Takashi Yoneda,Issey Osaka International Journal of Molecular Sciences 23 22 13858 2022/11/10 ?
- Impact of conducting adrenal venous sampling in the morning versus afternoon in primary aldosteronism Mau Yoneda,Mitsuhiro Kometani,Ko Aiga,Shigehiro Karashima,Mikiya Usukura,Shunsuke Mori,Yoshimichi Takeda,Daisuke Aono,Seigo Konishi,Kenichiro Okumura,Takahiro Ogi,Satoshi Kobayashi,Yoshiyu Takeda,Takashi Yoneda Journal of the Endocrine Society 2023/01/14 ?
- In vivo relationship between bound and free insulin in patients with diabetes having anti-insulin antibodies Hiroyuki Asaka,Shigehiro Karashima,Daisuke Chujo,Mitsuhiro Kometani,Mikiya Usukura,Kunimasa Yagi,Ko Aiga,Takashi Yoneda Diabetology International 2023
- A hyperaldosteronism subtypes predictive model using ensemble learning. Shigehiro Karashima,Masaki Kawakami,Hidetaka Nambo,Mitsuhiro Kometani,Isao Kurihara,Takamasa Ichijo,Takuyuki Katabami,Mika Tsuiki,Norio Wada,Kenji Oki,Yoshihiro Ogawa,Ryuji Okamoto,Kouichi Tamura,Nobuya Inagaki,Takanobu Yoshimoto,Hiroki Kobayashi,Miki Kakutani,Megumi Fujita,Shoichiro Izawa,Tetsuya Suwa,Kohei Kamemura,Masanobu Yamada,Akiyo Tanabe,Mitsuhide Naruse,Takashi Yoneda Scientific reports 13 1 3043 2023/02/21
- Impact of gut microbiome on serum IgG4 levels in the general population: Shika-machi super preventive health examination results Aoi Koshida,Shigehiro Karashima,Kohei Ogura,Yuna Miyajima,Kazuhiro Ogai,Ren Mizoguchi,Yasuo Ikagawa,Satoshi Hara,Ichiro Mizushima,Hiroshi Fujii,Mitsuhiro Kawano,Hiromasa Tsujiguchi,Akinori Hara,Hiroyuki Nakamura,Shigefumi Okamoto Frontiers in Cellular and Infection Microbiology 13 2023/10/16
- Hiccups as the first presentation of secondary adrenal insufficiency associated with advanced cervical cancer. Toshitaka Sawamura,Shigehiro Karashima,Ai Ohmori,Kei Sawada,Daisuke Aono,Mitsuhiro Kometani,Yoshiyu Takeda,Takashi Yoneda Endocrinology, diabetes & metabolism case reports 2022 2022/08/01
- Development of Subtype Diagnosis Prediction Algorithm for Primary Aldosteronism. 唐島成宙,唐島成宙,川上将輝,米谷充弘,成瀬光栄,南保英孝,米田隆,米田隆,米田隆 月刊糖尿病・内分泌代謝科 55 2 185 2022/08
- Effect of Intraprocedural Cortisol Measurement on ACTH-stimulated Adrenal Vein Sampling in Primary Aldosteronism. Mitsuhiro Kometani,Takashi Yoneda,Shigehiro Karashima,Yoshiyu Takeda,Mika Tsuiki,Akihiro Yasoda,Isao Kurihara,Norio Wada,Takuyuki Katabami,Masakatsu Sone,Takamasa Ichijo,Kouichi Tamura,Yoshihiro Ogawa,Hiroki Kobayashi,Shintaro Okamura,Nobuya Inagaki,Junji Kawashima,Megumi Fujita,Kenji Oki,Yuichi Matsuda,Akiyo Tanabe,Mitsuhide Naruse Journal of the Endocrine Society 6 9 bvac104 2022/09/01
- A case of adrenocortical carcinoma diagnosed 9 years after the discovery of adrenal incidentaloma. Daisuke Aono,Mitsuhiro Kometani,Takahiro Asano,Seigo Konishi,Shigehiro Karashima,Hiroko Ikeda,Takahiro Nohara,Takashi Yoneda Endocrine journal 2022/08/06
- Molecular and Epigenetic Control of Aldosterone Synthase, CYP11B2 and 11-Hydroxylase, CYP11B1. Yoshimichi Takeda,Masashi Demura,Mitsuhiro Kometani,Shigehiro Karashima,Takashi Yoneda,Yoshiyu Takeda International journal of molecular sciences 24 6 2023/03/17
- Impact of gut microbiome on the renin-aldosterone system: Shika-machi Super Preventive Health Examination results. Ren Mizoguchi,Shigehiro Karashima,Yuna Miyajima,Kohei Ogura,Mitsuhiro Kometani,Daisuke Aono,Seigo Konishi,Masashi Demura,Hiromasa Tsujiguchi,Akinori Hara,Hiroyuki Nakamura,Takashi Yoneda,Shigefumi Okamoto,Kenji Satou Hypertension research : official journal of the Japanese Society of Hypertension 2023/06/06
- Prediction and causal inference of cardiovascular and cerebrovascular diseases based on lifestyle questionnaires. Riku Nambo,Shigehiro Karashima,Ren Mizoguchi,Seigo Konishi,Atsushi Hashimoto,Daisuke Aono,Mitsuhiro Kometani,Kenji Furukawa,Takashi Yoneda,Kousuke Imamura,Hidetaka Nambo Scientific reports 14 1 10492 2024/05/07
- Prediction and causal inference of hyperuricemia using gut microbiota. Yuna Miyajima,Shigehiro Karashima,Ren Mizoguchi,Masaki Kawakami,Kohei Ogura,Kazuhiro Ogai,Aoi Koshida,Yasuo Ikagawa,Yuta Ami,Qiunan Zhu,Hiromasa Tsujiguchi,Akinori Hara,Shin Kurihara,Hiroshi Arakawa,Hiroyuki Nakamura,Ikumi Tamai,Hidetaka Nambo,Shigefumi Okamoto Scientific reports 14 1 9901 2024/04/30
- Adrenocortical carcinoma with circulating tumor DNA analysis at post-operative recurrence: a case report with review of literature. Daisuke Aono,Toshiaki Kato,Akina Morisawa,Sakuya Kimata,Seigo Konishi,Mitsuhiro Kometani,Takashi Yoneda,Kazuyoshi Hosomichi,Shigehiro Karashima Endocrine journal 2024/11/30
Conference Presentations
Others
Arts and Fieldwork
Patent
Theme to the desired joint research
○Development and Demonstration Research of a Future-Oriented Health Promotion and Medical Support Service Utilizing XR/AI
○Development of explainable disease prediction algorithms using medical big data
○Quantification and Imaging of Steroid Using Mass Spectrometry
Grant-in-Aid for Scientific Research
○「イオンモビリティ質量分析法を用いた毛髪メタボロミクスによる健康・疾患予測」(2023-2025)
○「腸内細菌叢相互ネットワークを標的にした生活習慣病改善フレームワークの開発」(2022-2024)
○「腸内細菌由来ステロイドホルモンによる塩感受性代謝制御ネットワークの解明」(2021-2024)
○「オンライン特定保健指導・オンライン診療におけるPHR活用による行動変容に関する研究」(2020-2023)
○「副腎皮質ホルモン由来の生活習慣病の早期診断法の開発と疾患原理の追及 」(2019-2021)
○「ステロイドメタボロミクス解析による生活習慣病発症バイオマーカーの探索的研究」(2019-2020)
○「原発性アルドステロン症の罹病率と遺伝子学 的背景及びステロイドプロファイルの検討 」(2017-2019)
Competitive research funding,Contribution
Collaborative research,Consignment study
Classes (Bachelors)
○Introduction to Technology(2024)
○Introduction to Technology(2024)
○Regulatory Science(2024)
○Introduction to Technology(2024)
○Reform of Medical System and Medical Economics(2024)
○Health Promotion of the Future(2024)
○Practical Health Promotion(2024)
○Practical Health Promotion(2024)
○Health Promotion of the Future(2024)
○Practical Health Promotion(2024)
○Health Promotion of the Future(2024)
○Practical Health Promotion(2024)
○Health Promotion of the Future(2024)
○Practice of Wellness Promotion(2024)
○Practice of Wellness Promotion(2024)
○Practice of Wellness Promotion(2024)
○Practice of Wellness Promotion(2024)
○Practice of Wellness Promotion(2024)
○Practice of Wellness Promotion(2024)
○Practice of Wellness Promotion(2024)
○Practice of Wellness Promotion(2024)
○Practice of Wellness Promotion(2024)
○Practice of Wellness Promotion(2024)
○Practice of Wellness Promotion(2024)
○Practice of Wellness Promotion(2024)
○Practice of Wellness Promotion(2024)
○Practice of Wellness Promotion(2024)
○Practice of Wellness Promotion(2024)
○Practice of Wellness Promotion(2024)
○Introduction to Technology(2023)
○Introduction to Technology(2023)
○Regulatory Science(2023)
○Introduction to Technology(2023)
○Reform of Medical System and Medical Economics(2023)
○Health Promotion of the Future(2023)
○Health Promotion of the Future(2023)
○Health Promotion of the Future(2023)
○Health Promotion of the Future(2023)
○Practice of Wellness Promotion(2023)
○Practice of Wellness Promotion(2023)
○Practice of Wellness Promotion(2023)
○Practice of Wellness Promotion(2023)
○Practice of Wellness Promotion(2023)
○Practice of Wellness Promotion(2023)
○Practice of Wellness Promotion(2023)
○Practice of Wellness Promotion(2023)
○Practice of Wellness Promotion(2023)
○Practice of Wellness Promotion(2023)
○Practice of Wellness Promotion(2023)
○Practice of Wellness Promotion(2023)
○Practice of Wellness Promotion(2023)
○Practice of Wellness Promotion(2023)
○Practice of Wellness Promotion(2023)
○Practice of Wellness Promotion(2023)
○Introduction to Technology(2022)
○Introduction to Technology(2022)
○Practice of Wellness Promotion(2022)
○Practice of Wellness Promotion(2022)
○Practice of Wellness Promotion(2022)
○Practice of Wellness Promotion(2022)
○Practice of Wellness Promotion(2022)
○Practice of Wellness Promotion(2022)
○Practice of Wellness Promotion(2022)
○Practice of Wellness Promotion(2022)
○Practice of Wellness Promotion(2022)
○Practice of Wellness Promotion(2022)
○Practice of Wellness Promotion(2022)
○Practice of Wellness Promotion(2022)
○Practice of Wellness Promotion(2022)
○Practice of Wellness Promotion(2022)
○Practice of Wellness Promotion(2022)
○Practice of Wellness Promotion(2021)
○Practice of Wellness Promotion(2021)
○Practice of Wellness Promotion(2021)
○Practice of Wellness Promotion(2021)
○Practice of Wellness Promotion(2021)
○Practice of Wellness Promotion(2021)
○Practice of Wellness Promotion(2021)
○Practice of Wellness Promotion(2021)
○Practice of Wellness Promotion(2021)
○Practice of Wellness Promotion(2021)
○Practice of Wellness Promotion(2021)
○Practice of Wellness Promotion(2021)
○Practice of Wellness Promotion(2021)
○Practice of Wellness Promotion(2021)
○Practice of Wellness Promotion(2021)
○Academic Skills(2021)
○Introduction to Technology(2021)
○Health Promotion of the Future(2020)
○Health Promotion of the Future(2020)
○Health Promotion of the Future(2020)
○Practice of Wellness Promotion(2020)
○Practice of Wellness Promotion(2020)
○Practice of Wellness Promotion(2020)
○Practice of Wellness Promotion(2020)
○Practice of Wellness Promotion(2020)
○Practice of Wellness Promotion(2020)
○Practice of Wellness Promotion(2020)
○Practice of Wellness Promotion(2020)
○Practice of Wellness Promotion(2020)
○Practice of Wellness Promotion(2020)
○Practice of Wellness Promotion(2020)
○Practice of Wellness Promotion(2020)
○Practice of Wellness Promotion(2020)