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Researcher Information

last modified：2024/09/02

Professor　KAWAI Keiichi

Mail Laboratory Website

Faculty, Affiliation

Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences

College and School Educational Field

Division of Health Sciences, Graduate School of Medical Science
Division of Health Sciences，Graduate School of Medical Science
Division of Material Sciences, Graduate School of Natural Science and Technology
Graduate School of Advanced Preventive Medical Sciences
Department of Radiological Technology，School of Health Sciences, College of Medical, Pharmaceutical and Health Sciences

Laboratory

　TEL:076-265-2527　FAX:076-234-4366

Academic Background

【Academic background(Doctoral/Master's Degree)】
Kyoto University　Doctor　Graduate School, Division of Pharmaceutical Sciences　198803　Unfinished course
Kyoto University　Master　Graduate School, Division of Pharmaceutical Sciences　198603　Completed
【Academic background(Bachelor's Degree)】
Kyoto University　198303
【Degree】
Ph.D.
M.S.

Career

Kanazawa University　Faculty of Health Sciences(2008/04/01-)
Kanazawa University　Graduate School of Medicine(2005/04/01-2008/03/31)
Kanazawa University　Faculty of Health Sciences(2001/04/01-2005/03/31)
Fukui University　Biomedical Imaging Research Center　Visiting Professor(2001/10/01-)
Miyazaki Medical College　Central Research Laboratories(1996/04/01-2001/03/31)
National Institutes of Health　PET Department, Clinical Center(1995/07/17-1995/08/04)
National Institutes of Health　PET Department, Clinical Center(1992/04/01-1993/03/31)
Science University of Tokyo　Faculty of Pharmaceutical Sciences(1988/04/01-1996/03/31)

Year & Month of Birth

1959/04

Academic Society




The Society of Nuclear Medicine
The Society of Radiopharmaceutical Chemistry and Biology


Award




Specialities

Radiopharmaceutical Chemistry、Nuclear Medicine、Medical Pharmaceutical Science

Speciality Keywords

Molecular Imaging, Radiopharmaceutical Chemistry, Pharmacokinetics

Research Themes

Radioprobe-based Molecular Imaging for Diagnosis of Metabolic Function

Radioprobe-based Molecular Imaging for Diagnosis of Metabolic Function The body develops and utilizes a variety of functional molecules to perform sophisticated biological processes at the cellular level accurately and rapidly. In particular, functional proteins such as tranporters, enzymes, and receptors play significant roles in metabolism and biological processes. Primarily with transporters and information transduction agents and biosynthetic enzymes as target molecules, in our lab we molecularly design and evaluate radiogenic diagnostic agents containing radionuclide that have affinity with them and are necessary for diagnostic imaging. This type of diagnostic imaging for metabolism function analysis, targeting functional molecules that are instrumental to metabolism and information transduction, is considered to be in the cutting-edge research area of “molecular imaging”, which has been attracting attention in recent years.

Regulation of Pharmacokinetics

Regulation of Pharmacokinetics Active elements of drugs that are administered may bind with polymer molecules or be discharged to the outside of the body after being absorbed, with no more than several percent reaching the target tissues. Controlling target accumulation inhibitors of active elements of drugs could enhance drug efficacy and reduce side effects when the same amount of the same active ingredient is administered. We invented a method for controlling serum protein binding and kidney elimination of drugs, demonstrated the indication effect of the kinetic control method for diagnostic imaging of a drug through imaging visualization, and acquired an international patent. Based on these research results, we are now dealing with disposition control methods to effectively utilize not only diagnostic drugs but also treatment drugs.

Evaluation of Radiopharmaceutical for Cancer Detection and Image-guided Planning Treatments

Evaluation of Radiopharmaceutical for Cancer Detection and Image-guided Planning Treatments Nuclear medicine diagnostic imaging using radiogenic diagnostic imaging drugs that accumulate in tumor cells has been applied not only for cancer detection but also for treatment effect evaluation and prognosis assessment. Further, internal radiotherapy drugs that are labeled by radionuclide that is effective in cell-killing have been developed, and there have been reports on their significant effect in a number of cases in which difficult-to-treat multiple metastatic cancer that had been treated by means of surgical operations and external radiation therapy was completely cured with one injection. Our lab has enabled drug therapy effect projection and side-effect prevention by pre-determining accumulation rates of the radiogenic drug in cancer and side-effect regions, and is developing diagnostic imaging drugs and internal radiotherapy drugs for cancer that can be labeled with both diagnostic radionuclide and therapeutic radionuiclide, to enable truly individualized medicine.

Books

  • 　PET and Molecular Imaging. State of the Art and Future Perspectives　Elsevier, Amsterdam　2004/04
  • 　Proceedings of International Symposium on Serum Albumin and α1-Acid Glycoprotein from Basic Sciences to Clinical Applications　Tokyo Print, Tokyo　2001/07
  • 　Recent Advances in Biomedical Imaging　Elsevier, Amsterdam　1997/04

Papers

  • 　Accumulation and the Mechanism of 123I-BMIPP, a Myocardial Fatty Acid Metabolism Scintigraphy Agent, in Cancer Cells.　Sato K., Hirayama Y., Mizutani A., Yao J., Higashino J., Kamitaka Y., Muranaka Y., Yamazaki K., Nishii R., Kobayashi M., Kawai K.　Int. J. Mol. Sci.　25　14　7747　2024/07
  • 　Development of Radioiodine-labeled Mequitazine for Evaluation of Hepatic CYP2D Activity.　Mizutani A., Kobayashi M., Nishi K., Fujita K., Takahashi K., Muranaka Y., Sato K., Kitamura M., Suzuki C., Nishii R., Shikano N., Magata Y., Ishida Y., Kunishima M., Fukuchi K., Kawai K.　Front. Pharmacol.　15　1397288　2024/06
  • 　SPECT Imaging of P. Aeruginosa Infection in Mice using 123I-BMIPP.　Nishiyama Y., Mizutani A., Kobayashi M., Muranaka Y., Sato K., Maki H., Kawai K.　Pharmaceutics　16　5　656　2024/05
  • 　Effective Nose-to-Brain Drug Delivery using a Combination System Targeting the Olfactory Region in Monkeys.　Sasaki K., Fukakusa S., Torikai Y., Suzuki C., Sonohata I., Kawahata T., Magata Y., Kawai K., Haruta S.　J. Control. Release　359　384-399　2023/06
  • 　Evaluation of L-Alanine Metabolism in Bacteria and Whole-Body Distribution with Bacterial Infection Model Mice.　Muranaka Y., Matsue M., Mizutani A., Kobayashi M., Sato K., Kondo A., Nishiyama Y., Ohata S., Nishi K., Yamazaki K., Nishii R., Shikano N., Okamoto S., Kawai K.　Int. J. Mol. Sci.　24　5　4775　2023/03

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  • 　Biological Distribution after Oral Administration of Radioiodine-labeled Acetaminophen to Estimate Gastrointestinal Absorption Function via OATPs, OATs and/or MRPs.　Sato K., Mizutani A., Muranaka Y., Yao J., Kobayashi M., Yamazaki K., Nishii R., Nishi K., Nakanishi T., Tamai I., Kawai K.　Pharmaceutics　15　2　497　2023/02
  • 　A Single High-Dose Irradiation Changes Accumulation of Methotrexate and Gene Expression Levels of SLC and ABC Transporters in Cancer Cells.　Sato K., Seki T., Mizutani A., Muranaka Y., Hirota S., Nishi K., Yamazaki K., Nishii R., Nakanishi T., Tamai I., Kawai K., Kobayashi M.　Front. Pharmacol.　13　1069321　2023/01
  • 　Measurement of Hepatic CYP3A4 and 2D6 Activity Using Radioiodine-labeled O-Desmethyl-venlafaxine.　Mizutani A., Kobayashi M., Aibe R., Muranaka Y., Nishi K., Kitamura M., Suzuki C., Nishii R., Shikano N., Magata Y., Ishida Y., Kunishima M., Kawai K.　Int. J. Mol. Sci.　23　19　11458　2022/09
  • 　123I-BMIPP, a Radiopharmaceutical for Myocardial Fatty Acid Metabolism Scintigraphy, Could Be Utilized in Bacterial Infection Imaging.　Muranaka Y., Mizutani A., Kobayashi M., Nakamoto K., Matsue M., Takagi F., Okazaki K., Nishi K., Yamazaki K., Nishii R., Shikano N., Okamoto S., Maki H., Kawai K.　Pharmaceutics　14　5　1008　2022/05
  • 　Indirect SPECT Imaging Evaluation for Possible Nose-to-brain Drug Delivery Using a Compound with Poor Blood-brain Barrier Permeability in Mice.　Mizutani A., Kobayashi M., Ohuchi M., Sasaki K., Muranaka Y., Torikai Y., Fukakusa S., Suzuki C., Nishii R., Haruta S., Magata Y., Kawai K.　Pharmaceutics　14　5　1026　2022/05
  • 　Comparison of L- and D-Amino acids for Bacterial Imaging at Lung Infection Mouse Model.　Muranaka Y., Mizutani A., Kobayashi M., Nakamoto K., Matsue M., Nishi K., Yamazaki K., Nishii R., Shikano N., Okamoto S., Kawai K.　Int. J. Mol. Sci.　23　5　2467　2022/01
  • 　Measurement of Gastrointestinal Absorption Activity via Organic Cation Transporter using Oral [123I]MIBG Administration.　Kobayashi M., Mizutani A., Muranaka Y., Nishi K., Komori H., Nishii R., Shikano N., Nakanishi T., Tamai I., Kawai K.　Pharmaceutics　14　1　61　2022/01
  • 　Inhibition of the Hepatic Uptake of 99mTc-Tetrofosmin using an Organic Cation Transporter Blocker.　Nishi K., Kobayashi M., Kikuchi M., Mizutani A., Muranaka Y., Tamai I., Kawai K., Kudo T.　Pharmaceutics　13　7　1073　2021/07
  • 　Assessment of Drug Transporters Involved in the Urinary Secretion of [99mTc]Dimercaptosuccinic Acid.　Kobayashi M., Mizutani A., Okamoto T., Muranaka Y., Nishi K., Nishii R., Shikano N., Nakanishi T., Tamai I., Kleinerman E.S., Kawai K.　Nucl. Med. Biol.　94-95　92-97　2021/01
  • 　[131I]MIBG Exports via MRP Transporters and Inhibition of the MRP Transporters Improves Accumulation of [131I]MIBG in Neuroblastoma.　Kobayashi M., Mizutani A., Nishi K., Muranaka Y., Nishii R., Shikano N., Nakanishi T., Tamai I., Kleinerman E.S., Kawai K.　Nucl. Med. Biol.　90-91　49-54　2020/09
  • 　Transport Mechanism and Affinity of [99mTc]Mercaptoacetyltriglycine ([99mTc]MAG3) on the Apical Membrane of Renal Proximal Tubule Cells.　Kobayashi M., Nishi K., Mizutani A., Okudaira H., Nakanishi T., Shikano N., Nishii R., Tamai I., Kawai K.　Nucl. Med. Biol.　84-85　33-37　2020/01
  • 　Imaging of Hepatic Drug Transporters with [131I]6-β-iodomethyl-19-norcholesterol.　Kobayashi M., Nishi K., Mizutani A., Hokama T., Matsue M., Tsujikawa T., Nakanishi T., Nishii R., Tamai I., Kawai K.　Sci. Rep.　9　1　e13413　2019/09
  • 　The Pharmacological Properties of 3-Arm or 4-Arm DOTA Constructs for Conjugation to α-melanocyte-stimulating Hormone Analogues for Melanoma Imaging.　Kobayashi M., Kato T., Washiyama K., Ihara M., Mizutani A., Nishi K., Flores II L.G., Nishii R., Kawai K.　PLoS One　14　3　e0213397　2019/04
  • 　An L-type Amino Acid Transporter-1 Specific Imaging Agent: Structure-function Relationships of Radioiodinated Tyrosine Derivatives.　Shikano N., Kanai Y., Kawai K., Inatomi J., Kim D.K., Endou H.　ASVIP　24　23-28　2019/03
  • 　Differential Diagnosis between Low-grade and High-grade Astrocytoma using System A Amino Acid Transport PET Imaging with C-11-MeAIB: A Comparison Study with C-11-Methionine PET Imaging.　Nishii R., Higashi T., Kagawa S., Arimoto M,, Kishibe Y., Takahashi M., Yamada S., Saiki M., Arakawa Y., Yamauchi H., Okuyama C., Hojo M., Munemitsu T., Sawada M., Kobayashi M., Kawai K., Nagamachi S., Hirai T., Miyamoto S.　Contrast Media Mol. Imaging　doi: 10.1155/2018/1292746　2018/06
  • 　Different Efflux Transporter Affinity and Metabolism of 99mTc-2-methoxyisobutylisonitrile and 99mTc-tetrofosmin for Multidrug Resistance Monitoring in Cancer Cells.　Kobayashi M., Tsujiuchi T., Okui Y., Mizutani A., Nishi K., Nakanishi T., Nishii R., Fukuchi K., Tamai I., Kawai K　Pharm. Res.　36　1　18　2018/11
  • 　Development of Radioiodine-labeled Acetaminophen for Specific, High-contrast Imaging of Malignant Melanoma.　Zhu W., Kobayashi M., Yamada K., Nishi K., Takahashi K., Mizutani A., Nishii R., Flores II L.G., Shikano N., Kunishima M., Kawai K.　Nucl. Med. Biol.　59　16-21　2018/03
  • 　Quantitative Metabolic Imaging to Detect Hepatic Carboxylesterase Drug-Metabolizing Enzyme Activity Using 123I-Iomazenil.　Mizutani A., Kobayashi M., Fujita K., Takahashi K., Hokama T., Takatsu H., Nishi K., Shikano N., Fukuchi K., Kawai K.　Nucl. Med. Commun.　39　9　825-833　2018/08
  • 　In Vitro Uptake and Metabolism of [14C]Acetate in Rabbit Atherosclerotic Arteries: Biological Basis for Atherosclerosis Imaging with [11C]Acetate.　Yamasaki K., Yamashita A., Zhao Y., Shimizu Y., Nishii R., Kawai K., Tamaki N., Zhao S., Asada Y., Kuge Y.　Nucl. Med. Biol.　56　21-25　2018/01
  • 　Relationship between [14C]MeAIB Uptake and Amino Acid Transporter Family Gene Expression Levels or Proliferative Activity in a Pilot Study in Human Carcinoma Cells: Comparison with [3H]Methionine Uptake.　Kagawa S., Nishii R., Higashi T., Yamauchi H., Ogawa E., Okudaira H., Kobayashi M., Yoshimoto M., Shikano N., Kawai K.　Nucl. Med. Biol.　49　8-15　2017/06
  • 　Altered Glucose Metabolism and Hypoxic Response in Alloxan-induced Diabetic Atherosclerosis in Rabbits.　Matsuura Y., Yamashita A., Zhao Y., Iwakiri T., Yamasaki K., Sugita C., Koshimoto C., Kitamura K., Kawai K., Tamaki N., Zhao S., Kuge Y., Asada Y.　PLos One　12　4　e0175976　2017/06
  • 　Difference in Accumulation and the Transport Mechanism of L- and D-Methionine in High- and Low-Grade Human Glioma Cells.　Kobayashi M., Mizutani A., Nishi K., Nakajima S., Shikano N., Nishii R., Fukuchi K., Kawai K.　Nucl. Med. Biol.　44　2　78-82　2017/02
  • 　Assessment of Amino Acid/Drug Transporters for Renal Transport of [18F]Fluciclovine (anti-[18F]FACBC) in vitro.　Ono M., Baden A., Okudaira H., Kobayashi M., Kawai K., Oka S., Yoshimura H.　Int. J. Mol. Sci.　17　10　1730　2016/10
  • 　A Novel Injection Strategy of Flurbiprofen-axetil by Inhibiting Protein Binding with 6-Methoxy-2-naphthylacetic Acid..　Ogata K., Takamura N., Tokunaga J., Ikeda T., Setoguchi N., Tanda K,., Yamasaki T., Nishio T., Kawai K.　Eur. J. Drug Metab. Pharmacok.　41　2　179-186　2016/04
  • 　Simultaneous Acquisition of 99mTc- and 123I-labeled Radiotracers using a Preclinical SPECT Scanner with CZT Detectors.　Kobayashi M., Matsunari I., Nishi K., Mizutani A., Miyazaki Y., Ogai K., Sugama J., Shiba K., Kawai K., Kinuya S　Ann. Nucl. Med.　30　4　263-271　2016/04
  • 　Impact of Injection Dose, Post-reconstruction Filtering, and Collimator Choice on Image Quality of Myocardial Perfusion SPECT using Cadmium-zinc Telluride Detectors in the Rat.　Mizutani A., Matsunari I., Kobayashi M., Nishi K., Fujita W., Miyazaki Y., Nekolla S.G., Kawai K.　EJNMMI Physics　2　1　7　2015/12
  • 　[14C]Fluciclovine (alias anti-[14C]FACBC) Uptake and ASCT2 Expression in Castration-resistant Prostate Cancer Cells.　Ono M., Oka S., Okudaira H., Nakanishi T., Mizokami A., Kobayashi M., Schuster D.M., Goodman M.M., Shirakami Y., Kawai K.　Nucl. Med. Biol.　42　11　887-892　2015/11
  • 　Comparison of Image Quality with 62Cu and 64Cu-labeled Radiotracers in Positron Emission Tomography Whole-body Phantom Imaging.　Kobayashi M., Mori T., Tsujikawa T., Ogai K., Sugama J., Kiyono Y., Kawai K., Okazawa H.　Hell. J. Nucl. Med.　18　2　103-107　2015/08
  • 　Development of Radioiodine-labeled 4-Hydroxyphenylcysteamine for Specific Diagnosis of Malignant Melanoma.　Kobayashi M., Nishii R., Shikano N., Flores II L.G., Mizutani A., Ogai K., Sugama J., Nagamachi S., Kawai K.　Nucl. Med. Biol.　42　6　536-540　2015/06
  • 　A Strategy for Improving FDG Accumulation for Early Detection of Metastasis from Primary Pancreatic Cancer: Stimulation of the Warburg Effect in AsPC-1 Cells.　Ogura M., Shikano N., Nakajima S., Sagara J., Yamaguchi N., Kusanagi K., Okui Y., Mizutani A., Kobayashi M., Kawai K.　Nucl. Med. Biol.　42　5　475-481　2015/05
  • 　In Vivo Radioactive Metabolite Analysis for Individualized Medicine: A Basic Study of a New Method of CYP Activity Assay using 123I-IMP.　Nishi K., Mizutani A., Shikano N., Fujita K., Kobayashi M., Ono M., Nishii R., Sasaki Y., Kinuya S., Kawai K.　Nucl. Med. Biol.　42　2　171-176　2015/02
  • 　Cross-linked Human Serum Albumin Dimer has the Potential for Use as a Plasma-retaining Agent for the Fatty Acid-conjugated Antidiabetic Drugs.　Taguchi K., Chuang V.T., Yamasaki K., Urata Y., Tanaka R., Anraku M., Seo H., Kawai K., Maruyama T., Komatsu T., Otagiri M.　J. Pharm. Pharmacol.　67　2　255-263　2015/02
  • 　Accumulation of trans-1-Amino-3-18F-fluorocyclobutanecarboxylic Acid in Prostate Cancer due to Androgen-induced Expression of Amino-acid Transporters.　Okudaira H., Oka S., Ono M., Nakanishi T., Schuster D.M., Kobayashi M., Goodman M.M., Tamai I., Kawai K., Shirakami Y.　Mol. Imaging Biol.　16　6　756-764　2014/12
  • 　Effect of Surrounding Materials on Iterative Reconstruction Based Line-Source Response Function, and Annihilations outside the Source Assessed by a Small Animal PET Scanner.　Miyazaki Y., Kobayashi M., Komatsu R., Hayashi A., Yonezawa S., Kawai K., Matsudaira M., Shiozaki J., Matsunari I.　Ann. Nucl. Med.　28　6　512-522　2014/07
  • 　Differences in Transport Mechanisms of Trans-1-amino-3-[18F]fluorocyclobutanecarboxylic Acid in Inflammatory, Prostate Cancer, and Glioma Cells: Comparison with L-[Methyl-11C]methionine and 2-Deoxy-2-[18F]fluoro-D-glucose.　Oka S., Okudaira H., Ono M., Schuster D.M., Goodman M.M., Kawai K., Shirakami Y.　Mol. Imaging Biol.　16　3　322-329　2014/06
  • 　Performance Evaluation of the eXplore speCZT Preclinical Imaging System.　Matsunari I., Miyazaki Y., Kobayashi M., Nishi K., Mizutani A., Kawai K., Hayashi A., Komatsu R., Yonezawa S., Kinuya S.　Ann. Nucl. Med.　28　5　484-497　2014/06
  • 　Intrastriatal Grafts of Fetal Ventral Mesencephalon Improve Allodynia-like Withdrawal Response to Mechanical Stimulation in a Rat Model of Parkinson's Disease.　Takeda R., Ishida Y., Ebihara K., Abe H., Matsuo H., Ikeda T., Koganemaru G., Kuramashi A., Funahashi H., Magata Y., Kawai K., Nishimori T.　Neurosci. Lett.　573　C　19-23　2014/06
  • 　Transport Mechanisms of Hepatic Uptake and Bile Excretion in Clinical Hepatobiliary Scintigraphy with 99mTc-N-pyridoxyl-5-methyltryptophan.　Kobayashi M., Nakanishi T., Nishi K., Higaki Y., Okudaira H., Ono M., Tsujiuchi T., Mizutani A., Nishii R., Tamai I., Arano Y., Kawai K.　Nucl. Med. Biol.　41　4　338-342　2014/04
  • 　Monitoring of Gefitinib Sensitivity with Radioiodinated PHY based on EGFR Expression.　Yoshimoto M., Hirata M., Kanai Y., Naka S., Nishii R., Kagawa S., Kawai K., Ohmomo Y.　Biol. Pharm. Bull.　37　3　355-360　2014/03
  • 　Influences of Artificial Heart-lung Machine Operation on the Binding Sites of Albumin: Possibility of an Effective Administration Plan.　Totoribe K., Takamura N., Ogata K., Tokunaga J., Kawai K., Nakamura K., Ieiri I., Higuchi S.　Int. J. Artif. Organs,　37　2　99-108　2014/02
  • 　Increased Metabolite Levels of Glycolysis and Pentose Phosphate Pathway in Rabbit Atherosclerotic Arteries and Hypoxic Macrophage.　Yamashita A., Zhao Y., Matsuura Y., Yamasaki K., Moriguchi-Goto S., Sugita C., Iwakiri T., Okuyama N., Koshimoto C., Kawai K., Tamaki N., Zhao S., Kuge Y., Asada Y.　PLoS One　9　1　e86426　2014/01
  • 　Prototype Imaging Protocols for Monitoring the Efficacy of Iodine-131 Ablation in Differentiated Thyroid Cancer.　Kobayashi M., Wakabayashi H., Kojima H., Konishi T., Okuda K., Yoneyama H., Kayano D., Tobisaka M., Tsushima H., Onoguchi M., Kawai K., Kinuya S.　Hell. J. Nucl. Med.　16　3　175-180　2013/09
  • 　Comparative Evaluation of Transport Mechanisms of Trans-1-amino-3-[18F]fluorocyclobutane-carboxylic Acid and L-[Methyl-11C]methionine in Human Glioma Cell Lines.　Ono M., Oka S., Okudaira H., Schuster D.M., Goodman M.M., Kawai K., Shirakami Y.　Brain Res.　1535　24-37　2013/08
  • 　Binding of Sulforhodamine B to Human Serum Albumin: A Spectroscopic Study.　Kitamura M., Murakami K., Yamada K., Kawai K., Kunishima M.　Dyes and Pigments.　99　3　588-593　2013/04
  • 　Arterial 18F-Fluorodeoxyglucose Uptake Reflects Balloon Catheter-induced Thrombus Formation and Tissue Factor Expression via Nuclear Factor-κB in Rabbit Atherosclerotic Lesions.　Yamashita A., Zhao Y., Zhao S., Matsuura Y., Sugita C., Iwakiri T., Okuyama N., Ohe K., Koshimoto C., Kawai K., Tamaki N., Kuge Y., Asada Y　Circ. J.　77　10　2679-2680　2013/07
  • 　Pharmacokinetic Alteration of 99mTc-MAG3 using Serum Protein Binding Displacement Method.　Nishi K., Kobayashi M., Nishii R., Shikano N., Takamura N., Kuga N., Yamasaki K., Nagamachi S., Tamura S., Otagiri M. and Kawai K. K., Shikano N., Nishii R., Higashi T., Okazawa H. and Kawai K.　NUCLEAR MEDICINE AND BIOLOGY　40　3　366-370　2013/03
  • 　Diagnostic Usefulness of an Amino Acid Tracer, α-[N-methyl-11C]-methylaminoisobutyric Acid (11C-MeAIB), in the PET Diagnosis of Chest Malignancies.　Nishii R., Higashi T., Kagawa S., Kishibe Y., Takahashi M., Yamauchi H., Motoyama H., Kawakami K., Nakaoku T., Nohara J., Okamura M., Watanabe T., Nakatani K., Nagamachi S., Tamura S., Kawai K., Kobayashi M.　Ann. Nucl. Med.　27　9　808-821　2013/07
  • 　Appropriate Collimators in a Small Animal SPECT Scanner with CZT Detector.　Higaki Y., Kobayashi M., Uehara T., Hanaoka H., Arano Y. and Kawai K.　ANNALS OF NUCLEAR MEDICINE　27　3　271-278　2013/03
  • 　Application of a Medium-energy Collimator for I-131 Imaging after Ablation Treatment of Differentiated Thyroid Cancer.　Kobayashi M., Wakabayashi H., Kayano D., Konishi T., Kojima H., Yoneyama H., Okuda K., Tsushima H., Onoguchi M., Kawai K., Kinuya S.　Ann. Nucl. Med.　28　6　551-558　2013/07
  • 　Predominant Contribution of L-Type Amino Acid Transporter to 4-Borono-2-18F-fluoro-phenylalanine Uptake in Human Glioblastoma Cells.　Yoshimoto M., Kurihara H., Honda N., Kawai K., Ohe K., Fujii H., Itami J. and Arai Y.　NUCLEAR MEDICINE AND BIOLOGY　40　5　625-629　2013/03
  • 　Kinetic Analyses of Trans-1-amino-3-18F-fluorocyclobutanecarboxylic Acid Transport in Xenopus Laevis Oocytes Expressing Human ASCT2 and SNAT2.　Okudaira H., Nakanishi T., Oka S., Kobayashi M., Tamagami H., Schuster D.M., Goodman M.M., Shirakami Y., Tamai I. and Kawai K.　NUCLEAR MEDICINE AND BIOLOGY　40　5　670-675　2013/03
  • 　The Usefulness of 18F-FDG PET/MRI Fusion Image in Diagnosing Pancreatic Tumor: Comparison with 18F-FDG PET/CT.　Nagamachi S., Nishii R., Wakamatsu H., Mizutani Y., Kiyohara S., Fujita S., Futami S., Sakae T., Furukoji E., Tamura S., Arita H., Chijiiwa K. and Kawai K.　ANNALS OF NUCLEAR MEDICINE　27　6　554-563　2013/03
  • 　A Diclofenac Suppository-nabumetone Combination Therapy for Arthritic Pain Relief and A Monitoring Method for The Diclofenac Binding Capacity of HSA Site II in Rheumatoid Arthritis.　Setoguchi N., Takamura N., Fujita K.I., Ogata K., Tokunaga J., Nishio T., Chosa E,., Arimori K., Kawai K. and Yamamoto R.　BIOPHARMACEUTICS & DRUG DISPOSITION　34　2　125-136　2013/02
  • 　Down-regulation of Calcium/calmodulin-dependent Protein Kinase Kinase 2 by Androgen Deprivation Induces Castration-resistant Prostate Cancer.　Shima T., Mizokami A., Miyagi T., Kawai K., Izumi K., Kumaki M., Ofude M., Zhang J., Keller E.T. and Namiki M.　PROSTATE　72　16　1789-1801　2012/12
  • 　Enhanced Expression of Organic Anion Transporting Polypeptides (OATPs) in Androgen Receptor-positive Prostate Cancer Cells: Possible Role of OATP1A2 in Adaptive Cell Growth under Androgen-depleted Conditions.　Arakawa H., Nakanishi T., Yanagihara C., Nishimoto T., Wakayama T., Mizokami A., Kawai K. and Tamai I.　BIOCHEMICAL PHARMACOLOGY　84　8　1070-1077　2012/08
  • 　Transport Mechanism of 11C-labeled L- and D-Methionine in Human-derived Tumor Cells.　Kobayashi M., Hashimoto F., Ohe K., Nadamura T., Nishi K., Shikano N., Nishii R., Higashi T., Okazawa H. and Kawai K.　NUCLEAR MEDICINE AND BIOLOGY　39　8　1213-1218　2012/08
  • 　N-Isopropyl-p-iodoamphetamine Hydrochloride (IMP) is Predominantly Metabolized by CYP2C19.　Fujita K., Sugiyama M., Akiyama Y., Hioki K., Kunishima M., Nishi K., Kobayashi M., Kawai K. and Sasaki Y.　DRUG METABOLISM AND DISPOSITION　40　5　843-846　2012/05
  • 　Appropriate Parameters of Ordered-Subset Expectation Maximization Algorithm on Measurement of Myocardial Blood Flow and Oxygen Consumption with 11C-Acetate PET.　Kobayashi M., Mori T., Kiyono Y., Tsujikawa T., Maruyama R., Higaki Y., Shikano N., Nishii R., Kawai K., Kudo T. and Okazawa H.　NUCLEAR MEDICINE COMMUNICATIONS　33　2　130-138　2012/02
  • 　The Agreement of Left Ventricular Function Parameters between 99mTc-Tetrofosmin Gated Myocardial SPECT and Gated Myocardial MRI.　Kuroiwa Y., Nagamachi S., Miyati T., Yamaguchi K., Nishii R., Kuga N., Azuma T., Arita H., Maeda M., Tamura S. and Kawai K.　ANNALS OF NUCLEAR MEDICINE　26　2　147-163　2012/02
  • 　Cerebral Oxygen Metabolism of Rats using Injectable 15O-Oxygen with a Steady-state Method.　Kobayashi M., Mori T., Kiyono Y., Tiwari V., Maruyama R., Kawai K. and Okazawa H.　JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM　32　1　33-40　2012/01
  • 　MR Signal Change in Venous Thrombus Relates Organizing Process and Thrombolytic Response in Rabbit.　Kuroiwa Y., Yamashita A., Miyati T., Furukoji E., Takahashi M., Azuma T., Sugimura H., Asanuma T., Tamura S., Kawai K. and Asada Y.　MAGNETIC RESONANCE IMAGING　29　7　975-984　2011/07
  • 　Functional Characterization of Apical Transporters Expressed in Rat Proximal Tubular Cells (PTCs) in Primary Culture.　Nakanishi T., Fukushi A., Sato M., Yoshifuji M., Gose T., Shirasaka Y., Ohe K., Kobayashi M., Kawai K. and Tamai I.　MOLECULAR PHARMACOLOGY　8　6　2142-2150　2011/06
  • 　Comparison of Diagnostic and Prognostic Capabilities of 18F-FDG PET/CT, 131I-scintigraphy, and Diffusion-weighted Magnetic Resonance Imaging for Postoperative Thyroid Cancer.　Nagamachi S., Wakamatsu H., Kiyohara S., Nishii R., Mizutani Y., Fujita S., Futami S., Arita H., Kuroki M., Nakada H., Uchino N., Tamura S. and Kawai K.　29　6　413-422　2011/06
  • 　Putative Transport Mechanism and Intracellular Fate of Anti-18F-FACBC (Trans-1-amino- 3-18F-fluorocyclobutanecarboxylic Acid) in Human Prostate Cancer.　Okudaira H., Shikano N., Nishii R., Miyagi T., Yoshimoto M., Kobayashi M., Ohe K., Nakanishi T., Tamai I., Namiki M. and Kawai K.　JOURNAL OF NUCLEAR MEDICINE　52　5　822-829　2011/05
  • 　Differential Expression of FosB, c-Fos, and Zif268 in Forebrain Regions after Acute or Chronic L-DOPA Treatment in a Rat Model of Parkinson’s Disease.　Ebihara K., Ishida Y., Takeda R., Abe H., Matsuo H., Kawai K., Magata Y. and Nishimori T.　NEUROSCIENCE LETTERS　496　2　90-94　2011/02
  • 　Development of an H215O Steady-state Method Combining a Bolus and Slow Increasing Injection with a Multiprogramming Syringe Pump.　Kobayashi M., Kiyono Y., Maruyama R., Mori T., Kawai K. and Okazawa H.　JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM　31　2　527-534　2011/02
  • 　Superior Plasma Retention of a Cross-linked Human Serum Albumin Dimer in Nephrotic Rats as a New Type of Plasma Expander.　Taguchi K., Urata Y., Anraku M., Watanabe H., Kawai K., Komatsu T., Tsuchida E., Maruyama T. and Otagiri M.　DRUG METABOLISM AND DISPOSITION　38　12　2124-2129　2010/12
  • 　Radioiodinated 4-Iodo-L-meta-tyrosine, a System L Selective Artificial Amino Acid: Molecular Design and Transport Characterizationin in Chinese Hamster Ovary Cells (CHO-K1 Cells).　Shikano N., Kotani T., Nakajima S., Ogura M., Nakazawa S., Sagara J., Kobayashi M., Baba T., Yamaguchi N., Kubota N. and Kawai K.　NUCLEAR MEDICINE AND BIOLOGY　37　8　903-910　2010/12
  • 　Inhibition of Cisplatin Protein Binding: a Possible Therapeutic Advantage.　Tokunaga J., Matsuo Y., Takamura N., Ogata K., Yoshida H., Nagata M., Kishimoto S., Fukushima S., Ikeda O., Nishio T., Kawai K. and Arimori K.　7　4　127-132　2010/07
  • 　The Citrus Flavonoids Hesperetin and Naringenin Block the Lipolytic Actions of TNF-α in Mouse Adipocytes.　Yoshida H., Takamura N., Shuto T., Ogata K., Tokunaga J., Kawai K. and Kai H.　BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　394　3　728-732　2010/06
  • 　The Reproducibility of Deep-inspiration Breath-hold 18F-FDG PET/CT Technique in Diagnosing Various Cancers Affected by Respiratory Motion.　Nagamachi S., Wakamatsu H., Kiyohara S., Fujita S., Futami S., Arita H., Tamura S. and Kawai K.　ANNALS OF NUCLEAR MEDICINE　24　3　171-178　2010/03
  • 　Basic Study on Flurbiprofen Protein Binding Inhibition by an Albumin Site II Binding Inhibitor, 6-Methoxy-2-naphthyl Acetic Acid.　Tokunaga J., Takamura N., Ogata K., Yoshida H., Setoguchi N., Kondo T., Nishio T. and Kawai K.　11　153-158　2010/03
  • 　Comparison of the Transcellular Transport of FDG and D-Glucose by the Kidney Epithelial Cell Line LLC-PK1.　Kobayashi M., Shikano N., Nishii R., Kiyono Y., Araki H., Nishi K., Oh M., Okudaira H., Ogura M., Yoshimoto M., Okazawa H., Fujibayashi Y. and Kawai K.　NUCLEAR MEDICINE COMMUNICATIONS　31　2　141-146　2010/02
  • 　Atherosclerotic Lesions Rich in Macrophages or Smooth Muscle Cells Discriminated in Rabbit Iliac Arteries Based on T1 Relaxation Time and Lipid Content.　Kuroiwa Y., Yamashita A., Miyati T., Furukoji E., Takahashi M., Azuma T., Sugimura H., Tamura S., Kawai K. and Asada Y.　ACADEMIC RADIOLOGY　17　2　230-238　2010/02
  • 　Stimulation of 125I-3-Iodo-alpha-methyl-L-tyrosine in Chinese Hamster Ovary (CHO-K1) Cells by Tyrosine Esters. 　Nakajima S., Shikano N., Kotani T., Ogura M., Nishii R., Yoshimoto M., Yamaguchi N., Iwamura Y., Kubota N., Ishikawa N. and Kawai K.　NUCLEAR MEDICINE AND BIOLOGY　37　2　189-196　2010/02
  • 　Uptake of 3-[125I]Iodo-α-methyl-L-tyrosine into Colon Cancer DLD-1 Cells: Characterization and Inhibitory Effect of Natural Amino Acids and Amino Acid-like Drugs.　Shikano N., Ogura M., Okudaira H., Nakajima S., Kotani T., Kobayashi M., Nakazawa S., Baba T., Yamaguchi N., Kubota N., Iwamura Y. and Kawai K.　NUCLEAR MEDICINE AND BIOLOGY　37　2　197-204　2010/02
  • 　Intracellular Reactions Affecting 2-Amino-4-([11C]methylthio)butyric acid ([11C]Methionine) Response to Carbon Ion Radiotherapy in C10 Glioma Cells.　Nakajima S., Shikano N., Kotani T., Ogura M., Nishii R., Yoshimoto M., Yamaguchi N., Iwamura Y., Kubota N., Ishikawa N. and Kawai K.　NUCLEAR MEDICINE AND BIOLOGY　36　8　985-991　2009/12
  • 　Evaluation of Radioiodinated Vesamicol Analogs for Sigma Receptor Imaging in Tumor and Radionuclide Receptor Therapy.　Ogawa K., Shiba K., Akhter N., Yoshimoto M., Washiyama K., Kinuya S., Kawai K. and Mori H.　100　11　2188-2192　2009/11
  • 　Improvement of N-isopropyl-p-[123I]iodoamphetamine Cerebral Accumulation by Competitive Displacement of Serum Protein Binding with Amino-Acid Infusion.　Kuga N., Shikano N., Takamura N., Nishii R., Yamasaki K., Kobayashi M., Nagamachi S., Tamura S. and Kawai K.　JOURNAL OF NUCLEAR MEDICINE　50　8　1378-1383　2009/08
  • 　Usefulness of a Deep-inspiration Breath-hold 18F-FDG PET/CT Technique in Diagnosing Liver, Bile Duct, and Pancreas Tumors.　Nagamachi S., Wakamatsu H., Kiyohara S., Fujita S., Futami S., Arita H., Nishii R., Tamura S. and Kawai K.　NUCLEAR MEDICINE COMMUNICATIONS　30　5　326-332　2009/05
  • 　Usefulness of Competitive Inhibitors of Protein Binding for Improving the Pharmacokinetics of 186Re-MAG3-conjugated Bisphosphonate (186Re-MAG3-HBP), an Agent for Treatment of Painful Bone Metastases.　Ogawa K., Mukai T., Kawai K., Takamura N., Hanaoka H., Hashimoto K., Shiba K., Mori H. and Saji H.　EUROPEAN JOURNAL OF NUCLEAR MEDICINE　36　1　115-121　2009/01
  • 　Altered Chain-length and Glycosylation Modify the Pharmacokinetics of Human Serum Albumin.　Iwao Y., Hiraike M., Kragh-Hansen U., Kawai K., Suenaga A., Maruyama T. and Otagiri M.　BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY　1794　4　634-641　2009/01
  • 　Serum Protein Binding Displacement: Theoretical Analysis using a Hypothetical Radiopharmaceutical and Experimental Analysis with 123I-N-isopropyl-p-iodoamphetamine.　Kawai K., Nishii R., Shikano N., Makino N., Kuga N., Yoshimoto M., Jinnouchi S., Nagamachi S., Tamura S. and Takamura N.　NUCLEAR MEDICINE AND BIOLOGY　36　1　99-106　2009/01
  • 　Differential Expression of Fos and Zif268 in the Nigrostriatal System after Methamphetamine Administration in a Rat Model of Parkinson’s Disease.　Ishida Y., Kawai K., Magata Y., Ebihara K., Takeda R., Abe H., Yoshimoto M., Hashiguchi H., Odagiri K., Matsuo H. and Nishimori T.　SYNAPSE　62　12　920-926　2008/12
  • 　Usefulness of rCBF Analysis in Diagnosing Parkinson's Disease: Supplemental Role with MIBG Myocardial Scintigraphy.　Nagamachi S., Wakamatsu H., Kiyohara S., Fujita S., Futami S., Tamura S., Nakazato M., Yamashita S., Arita H., Nishii R. and Kawai K.　ANNALS OF NUCLEAR MEDICINE　22　7　557-564　2008/12
  • 　αvβ3 Integrin-targeting Radionuclide Therapy and Imaging with Monomeric RGD Peptide.　Yoshimoto M., Ogawa K., Washiyama K., Shikano N., Mori H., Amano R. and Kawai K.　INTERNATIONAL JOURNAL OF CANCER　123　3　709-715　2008/08
  • 　Influence of Haemodialysis on the Binding Sites of Human Serum Albumin; Possibility of an Efficacious Administration Plan using Binding Inhibition.　Nishio T., Takamura N., Nishii R., Tokunaga J., Yoshimoto M. and Kawai K.　NEPHROLOGY DIALYSIS TRANSPLANTATION　23　7　2304-2310　2008/07
  • 　Assessment of Diastolic Function using 16-frame 201Tl Gated Myocardial Perfusion SPECT: A Comparative Study of QGS2 and pFAST2.　Nagamachi S., Wakamatsu H., Fujita S., Nishii R., Kamimura K., Kiyohara S., Futami S., Onitsuka H., Nagoshi Y., Tamura S., Kawai K. and Arita H.　ANNALS OF NUCLEAR MEDICINE　22　2　115-122　2008/02
  • 　Dosage Plan of Flurbiprofen Injection Product using Inhibition of Protein Binding by Lipid Emulsion in Rats.　Ogata K., Takamura N., Tokunaga J., Kawai K., Arimori K. and Higuchi S.　JOURNAL OF PHARMACY AND PHARMACOLOGY　60　1　15-20　2008/01
  • 　Changes of Net Charge and Alpha-helical Content Affect the Pharmacokinetic Properties of Human Serum Albumin.　Iwao Y., Hiraike M., Kragh-Hansen U., Mera K., Noguchi T., Anraku M., Kawai K., Maruyama T. and Otagiri M.　BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY　1774　12　1582-1590　2007/10
  • 　Pharmacokinetics of 3-[125I]Iodo--methyl-L-tyrosine, a Tumor Imaging Agent, after Probenecid Loading in Mice Implanted with Colon Cancer DLD-1 Cells.　Nakajima S., Shikano N., Kotani T., Ogura M., Nishii R., Yoshimoto M., Yamaguchi N., Iwamura Y., Kubota N., Ishikawa N. and Kawai K.　NUCLEAR MEDICINE AND BIOLOGY　34　8　1003-1008　2007/08
  • 　Transport of D-[1-14C]-Amino Acids into Chinese Hamster Ovary (CHO-K1) Cells: Implications for Use of Labeled D-Amino Acids as Molecular Imaging Agents.　Shikano N., Nakajima S., Kotani T., Ogura M., Sagara J., Iwamura Y., Yoshimoto M., Kubota N., Ishikawa N. and Kawai K.　NUCLEAR MEDICINE AND BIOLOGY　34　6　659-665　2007/06
  • 　Diagnosis of Misery Perfusion using Noninvasive 15O Gas PET.　Kobayashi M., Okazawa H., Tsuchida T., Kawai K., Fujibayashi Y. and Yonekura Y.　JOURNAL OF NUCLEAR MEDICINE　47　10　1581-1586　2006/10
  • 　Radio-iodinated VEGF to Image Tumor Angiogenesis in a LS180 Tumor Xenograft Model.　Yoshimoto M., Kinuya S., Kawashima A., Nishii R., Yokoyama K. and Kawai K.　NUCLEAR MEDICINE AND BIOLOGY　33　8　963-969　2006/08
  • 　Recombinant Human Serum Albumin Dimer has High Blood Circulation Activity and Low Vascular Permeability in Comparison with Native Human Serum Albumin.　Matsushita S., Chuang V.T., Kanazawa M., Tanase S., Kawai K., Maruyama T., Suenaga A. and Otagiri M.　PHARMACEUTICAL RESEARCH　23　5　882-891　2006/05
  • 　Oxidation of Arg-410 Promotes the Elimination of Human Serum Albumin.　Iwao Y., Anraku M., Yamasaki K., Kragh-Hansen U., Kawai K., Maruyama T. and Otagiri M.　BIOCHIMICA ET BIOPHYSICA ACTA-PROTEIN STRUCTURE AND MOLECULAR ENZYMOLOGY　1764　4　743-749　2006/04
  • 　Detection of Maleate-induced Fanconi Syndrome by Decreasing Accumulation of 125I-3-Iodo--methyl-L-tyrosine in the Proximal Tubule Segment-1 Region of Renal Cortex in Mice: A Trial of Separate Evaluation of Reabsorption.　Shikano N., Nakajima S., Kotani T., Itoh Y., Nishii R., Yoshimoto M., Flores II L.G., Saji H., Ishikawa N. and Kawai K.　ANNALS OF NUCLEAR MEDICINE　20　3　175-181　2006/03
  • 　The Structural and Pharmacokinetic Properties of Oxidized Human Serum Albumin, Advanced Oxidation Protein Products (AOPP).　Iwao Y., Anraku M., Hiraike M., Kawai K., Nakajou K., Kai T., Suenaga A. and Otagiri M.　21　2　140-146　2006/02
  • 　Effect of Percutaneous Endoscopic Gastrostomy on Gastrointestinal Motility: Evaluation by Gastric-emptying Scintigraphy.　Wakamatsu H., Nagamachi S., Nishii R., Higaki K., Kawai K., Kamimura K., Fujita S., Futami S. and Tamura S.　NUCLEAR MEDICINE COMMUNICATIONS　29　6　562-567　2008/06
  • 　Bucolome, a Potent Binding Inhibitor for Furosemide, Alters the Pharmacokinetics and Diuretic Effect of Furosemide: Potential for Use of Bucolome to Restore Diuretic Response in Nephrotic Syndrome.　Takamura N., Maruyama T., Chosa E., Kawai K., Tsutsumi Y., Uryu Y., Yamasaki K., Deguchi T. and Otagiri M.　DRUG METABOLISM AND DISPOSITION　33　4　596-602　2005/04
  • 　Inhibitory Effects of Amino-acid Fluids on Drug Binding to Site II of Human Serum Albumin in vitro.　Yamasaki K., Kuga N., Takamura N., Furuya Y., Hidaka M., Iwakiri T., Nishii R., Okumura M., Kodama H., Kawai K. and Arimori K.　BIOLOGICAL & PHARMACEUTICAL BULLETIN　28　3　549-552　2005/03
  • 　Regional Distribution of Manganese, Iron, Copper and Zinc in the Brains of 6-Hydroxydopamine-indeced Parkinsonian Rats.　Tarohda T., Ishida Y., Kawai K., Yamamoto M. and Amano R.　383　2　224-234　2005/02
  • 　Alteration of Striatal [11C]Raclopride and 6-[18F]Fluoro-L-3,4-dihydroxyphenylalanine Uptake Precedes Development of Methamphetamine-induced Rotation Following Unilateral 6-Hydroxydopamine Lesions of Medial Forebrain Bundle in Rats.　Ishida Y., Kawai K., Magata Y., Abe H., Yoshimoto M., Takeda R., Hashiguchi H., Mukai T. and Saji H.　NEUROSCIENCE LETTERS　389　1　30-34　2005/01
  • 　Cerebral Blood Flow Abnormalities Induced by Transient Hypothyroidism after Thyroidectomy. —Analysis by Tc-99m-HMPAO and SPM96 —.　Nagamachi S., Jinnouchi S., Nishii R., Ishida Y., Fujita S., Futami S., Kodama T., Tamura S. and Kawai K.　ANNALS OF NUCLEAR MEDICINE　18　6　469-477　2004/11
  • 　Changes in Dopamine D2 Receptors and 6-[18F]Fluoro-L-3,4-dihydroxyphenylalanine Uptake in the Brain in 6-Hydroxydopamine Lesioned Rats.　Ishida Y., Kawai K., Magata Y., Takeda R., Hashiguchi H., Abe H., Mukai T. and Saji H.　1　2-3　109-112　2004/07
  • 　Renal Accumulation and Excretion of Radioiodinated 3-Iodo-α-methyl-L-tyrosine.　Shikano N., Kawai K., Nakajima S., Nishii R., Flores II L.G., Kubodera A., Kubota N., Ishikawa N. and Saji H.　ANNALS OF NUCLEAR MEDICINE　18　3　263-270　2004/05
  • 　Transcellular Transport of Radioiodinated 3-Iodo-α-methyl-L-tyrosine across Monolayers of Kidney Epithelial Cell Line LLC-PK1.　Shikano N., Kawai K., Nakajima S., Kubodera A., Kubota N., Ishikawa N. and Saji H.　ANNALS OF NUCLEAR MEDICINE　18　3　227-234　2004/05
  • 　Transcellular Transport of 4-Iodo-L-meta-tyrosine via System L across Monolayers of Kidney Epithelial Cell Line LLC-PK1.　Shikano N., Kawai K., Nakajima S., Kubodera A., Kubota N., Ishikawa N. and Saji H.　NUCLEAR MEDICINE AND BIOLOGY　31　4　477-482　2004/04
  • 　Transport of 99mTc-MAG3 via Rat Renal Organic Anion Transporter 1.　Shikano N., Kanai Y., Kawai K., Ishikawa N. and Endou H.　JOURNAL OF NUCLEAR MEDICINE　45　1　80-85　2004/01
  • 　A Novel Radiopharmaceutical for Detection of Malignant Melanoma Based on Melanin Formation: 3-Iodo-4-hydroxyphenyl-L-cystein.　Nishii R., Kawai K., Flores II L.G., Kataoka H., Jinnouchi S., Nagamachi S., Arano Y. and Tamura S.　NUCLEAR MEDICINE COMMUNICATIONS　24　5　575-582　2003/05
  • 　Varidation of the Chloramine-T Induced Oxidation of Human Serum Albumin as a Model for Oxidative Damege in vivo.　Anraku M., Kragh-Hansen U., Kawai K., Maruyama T., Yamasaki Y., Takakura Y. and Otagiri M.　PHARMACEUTICAL RESEARCH　20　4　684-692　2003/04
  • 　An Artificial Amino Acid, 4-Iodo-L-meta-tyrosine: Biodistribution and Excretion via Kidney.　Shikano N., Kawai K., Flores II L.G., Nishii R., Kubota N., Ishikawa N. and Kubodera A.　JOURNAL OF NUCLEAR MEDICINE　44　4　625-631　2003/04
  • 　Isoform Selectivity of 3-125I-iodo-α-methyl-L-tyrosine Membrane Transport in Human L-Type Amino Acid Transporters.　Shikano N., Kanai Y., Kawai K., Inatomi J., Kim D.K., Ishikawa N. and Endou H.　JOURNAL OF NUCLEAR MEDICINE　44　2　244-246　2003/02
  • 　Characterization of 3-[125I]Iodo-α-methyl-L-tyrosine Transport via Human L-Type Amino Acid Transporter 1.　Shikano N., Kanai Y., Kawai K., Ishikawa N. and Endou H.　NUCLEAR MEDICINE AND BIOLOGY　30　1　31-37　2003/01
  • 　Prediction of Plasma Concentration-Time Curve of Orally Administered Theophylline Based on a Scintigraphic Monitoring of Gastrointestinal Transit in Human Volunteers.　INTERNATIONAL JOURNAL OF PHARMACEUTICS　233　1-2　179-190　2002/02
  • 　Serial Change in 123I-MIBG Myocardial Scintigraphy in Non-insulin-dependent Diabetes Mellitus.　ANNALS OF NUCLEAR MEDICINE　16　1　33-38　2002/02
  • 　The Correlation between 99mTc-MIBI Uptake and MIB-1 as a Nuclear Proliferation Marker in Glioma : A Comparative Study with 201Tl.　Nagamachi S., Jinnouchi S., Nabeshima K., Nishii R., Flores II L.G., Kodama T., Kawai K., Tamura S., Yokogami K., Samejima T. and Wakisaka S.　NEURORADIOLOGY　43　12　1023-1030　2001/12
  • 　Regulation of 123I-IMP Cerebral Accumulation by Competitive Displacement of Serum Protein Binding.　JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS　44　462-464　2001/05
  • 　Evaluation of Absorption Kinetics of Orally Administered Theophylline in Rats Based on Gastrointestinal Transit by Gamma Scintigraphy.　JOURNAL OF PHARMACEUTICAL SCIENCES　90　4　464-473　2001/04
  • 　A New Probe for the Cerebral Dopaminergic Presynaptic Function: 6-Radioiodinated L-meta-Tyrosine.　JOURNAL OF CEREBRAL BLOOD FLOW AND METABOLISM　20　1　207-212　2000/02
  • 　Evaluation of DOPA Decarboxylase Activity in Presynaptic Dopaminergic Neuron with 6-Radioiodinated L-meta-Tyrosine.　JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS　42　420-422　1999/11
  • 　Brain Uptake of Iodinated L-meta-Tyrosine, a Metabolically Stable Amino Acid Derivative.　NUCLEAR MEDICINE COMMUNICATIONS　20　2　153-157　1999/02
  • 　Assessment of the Radiochemical Design of Antibodies with a Metabolizable Linkage for Target-selective Radioactivity Delivery.　BIOCONJUGATE CHEMISTRY　9　4　497-506　1998/07
  • 　A Novel Radioiodination Reagent for Protein Radiopharmaceuticals with L-Lysine as a Plasma-stable Metabolizable Linkage to Liberate m-Iodohippuric Acid after Lysosomal Proteolysis.　JOURNAL OF MEDICINAL CHEMISTRY　40　16　2643-2652　1997/07
  • 　Synthesis and Evaluation of Radioiodinated 6-Iodo-L-DOPA as a Cerebral L-Amino Acid Transport Marker.　Kawai K., Ohta H., Kubodera A., Channing M.A. and Eckelman W.C.　NUCLEAR MEDICINE AND BIOLOGY　23　3　251-255　1996/03
  • 　Synthesis of Polymer-bound 6-Mercuric Carboxylate DOPA Precursors and Solid Phase Labeling Method of 6-Radioiodinated L-DOPA.　Kawai K., Ohta H., Channing M.A., Kubodera A. and Eckelman W.C.lman W.C.　APPLIED RADIATION AND ISOTOPES　47　1　37-44　1996/01
  • 　Canine SPECT Studies for Cerebral Amino Acid Transport by Means of 123I-3-iodo-α-methyl-L-tyrosine and Preliminary Kinetic Analysis.　Kawai K., Fujibayashi Y., Yonekura Y., Tanaka K., Saji H., Konishi J., Kubodera A. and Yokoyama A.　ANNALS OF NUCLEAR MEDICINE　9　1　47-50　1995/02
  • 　Synthesis of Polymer-bound 6-Thiolatomercury and 6-Mercuric Sulfonate DOPA Precursors and Their Halodemercuration Reactivity.　Kawai K., Channing M.A., Kiesewetter D.O. and Eckelman W.C.　NUCLEAR MEDICINE AND BIOLOGY　22　1　37-43　1995/01
  • 　An Artificial Amino Acid Radiopharmaceutical for Single Photon Emission Computed Tomographic Study of Pancreatic Amino Acid Transports: 123I-3-iodo-alpha-methyl-L-tyrosine.　Kawai K., Fujibayashi Y., Yonekura Y., Konishi J., Saji H., Kubodera A. and Yokoyama A.　ANNALS OF NUCLEAR MEDICINE　6　3　169-175　1992/04
  • 　A Strategy for the Study of Cerebral Amino Acid Transport Using 123I-labeled Amino Acid Radiopharmaceutical: 3-Iodo-alpha-methyl-L-tyrosine.　Kawai K., Fujibayashi Y., Saji H., Yonekura Y., Konishi J., Kubodera A. and Yokoyama A.　JOURNAL OF NUCLEAR MEDICINE　32　5　819-824　1991/05
  • 　Myocardial Uptake of Radioiodinated Methyl-branched Fatty Acids: Acute Inhibition of Beta-oxidation and Chronic Myocardial Damage.　Yonekura Y., Fujibayashi Y., Kawai K., Tamaki N., Yamamoto K., Matsumori A., Ohkusa T., Yokoyama A., Kawai C. and Konishi J.　21　226-228　1990/05
  • 　Monoiodo-D-tyrosine, an Artificial Amino Acid Radiopharmaceutical for Selective Measurement of Membrane Amino Acid Transport in the Pancreas.　Kawai K., Fujibayashi Y., Saji H., Konishi J., Kubodera A. and Yokoyama A.　NUCLEAR MEDICINE AND BIOLOGY　17　4　369-376　1990/04
  • 　Problems of [S-methyl-11C]-L-methionine as a Protein Synthesis Marker in the Pancreas.　Fujibayashi Y., Kawai K., Yonekura Y., Matsumoto K., Konishi J. and Yokoyama A.　ANNALS OF NUCLEAR MEDICINE　4　1　29-33　1990/02
  • 　New Approach for the Search of Exploitable Function of Amino Acid as for Pancreatic Radiopharmaceutical.　Fujibayashi Y., Kawai K., Saji H., Torizuka K. and Yokoyama A.　JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS　23　1363-1365　1986/12
  • 　A Radiopharmaceutical for Pancreatic Exocrine Functional Diagnosis: Zn-62-EDDA Metabolism in Pancreas.　Fujibayashi Y., Saji H., Kawai K., Unuma Y., Miyata S., Okuno T., Hosotani R., Inoue K., Adachi H., Horiuchi K., Torizuka K. and Yokoyama A.　NUCLEAR MEDICINE AND BIOLOGY　12　6　447-451　1986/06
  • 　Zn-62-EDDA: A Radiopharmaceutical for Pancreatic Functional Diagnosis.　Fujibayashi Y., Saji H., Yomoda I., Kawai K., Horiuchi K., Adachi H., Torizuka K. and Yokoyama A.　NUCLEAR MEDICINE AND BIOLOGY　12　6　439-446　1986/06
  • 　[I-125] Radioiodinated Metaraminol: A New Platelet-specific Labeling Agent.　Ohmomo Y., Yokoyama A., Kawai K., Arano Y., Horiuchi K., Tanaka C., Saji H. and Torizuka K.　EUROPEAN JOURNAL OF NUCLEAR MEDICINE　10　5-6　269-275　1985/05

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  • 　Nuclear Medicine: Molecular Imaging and Evidence-Based Personalized Medicine.　Keiichi Kawai　48　1　1-10　2024/08

Arts and Fieldwork

Patent

○Method of Measuring Binding Site on Plasma Protein of Plasma Protein-Binding Drug and Method of Measuring Plasma Protein Mutation(No：JP4236050,US7175991,EP1557671,TW I 33071)
○Preparation for Controlling Binding of Drug to Plasma Protein(No：TW I 306762)
○Method of the Administration of Drugs having Binding Affinity with Plasma Protein and Preparation to be used in the Method(country：USA, EU, Canada)(No：JP4343473,US7029653,EP1197227,CA2376159)

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「細胞内レドックス制御を司るがん幹細胞治療の標的トランスポーター画像診断薬の開発」(2022-2025)　
○「原発性アルドステロン症における新治療戦略ー安全かつ高奏功な根本治療の開発」(2022-2025)　
○「がん特異的グルタミノリシスを利用したミトコンドリア標的セラノスティクス薬剤の開発」(2022-2024)　
○「脳内アミノ酸代謝機能の画像診断を目的とした放射性診断薬の開発に関する基礎研究」(1995-1995)　
○「ナトリウム共役能動輸送型糖輸送体を標的としたセラノスティクス薬剤の開発」(2021-2024)　
○「個別化薬物療法最適化の基盤となる薬物代謝酵素活性を評価する核医学画像診断法の確立」(2018-2020)　
○「副作用が懸念される薬物の腎尿細管分泌機序の解明と新規腎機能核医学画像測定法の開発」(2018-2020)　
○「PET分子画像診断によるEGFR阻害癌分子標的薬個別化医療」(2016-2020)　
○「プロスタグランジン輸送体を作用標的とする新規抗炎症薬の提唱」(2015-2016)　
○「抗がん剤の個別化医療を可能にするSPECTを利用した高精度多剤耐性予測法の確立」(2015-2017)　
○「癌関連トランスポーター発現解析に基づく機能性分子発現系による腫瘍診断薬の開発戦略」(2015-2016)　
○「動脈硬化の治療戦略に役立つ核医学イメージング法：EBMのための実験的研究」(2014-2017)　
○「精神神経疾患の個体差を克服する個別化薬物療法に有用な分子標的放射性診断薬の開発」(2013-2016)　
○「半導体検出器を搭載した最新型小動物用SPECT/CT装置における定量測定法の確立」(2012-2014)　
○「細胞の遺伝子発現解析に基づく機能性分子発現系を利用した腫瘍診断薬の設計戦略の検証」(2012-2014)　
○「ＨＤＡＣ分子標的エピジェネティクスＰＥＴ診断の基礎及び臨床的応用」(2011-2014)　
○「不安定プラークの早期・特異的同定：プレターゲティング法による組織因子イメージング」(2011-2012)　
○「ヒト培養細胞の機能性分子発現解析に基づくポストFDG腫瘍診断薬の設計戦略の構築」(2009-2011)　
○「脳内神経変性疾患に対する再生医療・遺伝子治療効果判定に有用な放射性診断薬の開発」(2008-2011)　
○「ヒストン脱アセチル化酵素(HDAC)阻害に基づく癌分子標的PET診断法の開発」(2008-2010)　
○「量子医療技術による機能イメージング法のリハビリテーション医療への応用に関する研究」(2008-2010)　
○「悪性神経内分泌腫瘍に対する血管新生阻害下内用療法：基礎研究から臨床応用へ」(2007-2010)　
○「小腸粘膜における初回通過効果の解析とその薬物経口吸収挙動の予測への応用」(2007-2008)　
○「腫瘍血管新生の可視化を可能にする分子イメージング剤の開発」(2007-2009)　
○「シグナル伝達を指標にした分子イメージングによる癌分子標的薬剤治療効果予測法の開発」(2006-2008)　
○「脳内神経変性疾患に対する再生医療効果判定を可能にする新規放射性診断薬の開発」(2005-2007)　
○「アイソフォーム特異的アミノ酸トランスポーター放射性機能診断薬の実現」(2005-2007)　
○「薬物の経口吸収動態を制御する生理学的因子の解析とその吸収挙動予測への応用」(2005-2006)　
○「ポストFDGを担う腫瘍診断用ポジトロン放出核種標識人工アミノ酸製剤の探索」(2005-2007)　
○「癌細胞膜アビジン発現とスカベンジャー受容体内在化による特異的普遍的内照射法の開発」(2004-2006)　
○「分子イメージングによる核医学診断のための放射性医薬品の創薬戦略に関する研究」(2003-2003)　
○「transporter 遺伝子導入による腫瘍の内照射療法および核医学画像診断法の開発」(2003-2005)　
○「脳内神経変性疾患の早期検出を可能にする新規放射性診断薬の開発に関する研究」(2002-2004)　
○「低酸素腫瘍を標的とする内部照射治療薬剤に関する研究」(2002-2004)　
○「腫瘍内アミノ酸・アミン代謝を利用した癌の内部照射治療薬剤の検索」(2002-2004)　
○「アイソフォーム選択的アミノ酸トランスポーター画像診断薬の実現」(2001-2003)　
○「がんの内用放射線治療薬剤の開発研究」(2001-2001)　
○「腫瘍特異的代謝亢進に基づく癌の内部照射治療を可能にするヨウ素標識薬剤の開発」(2000-2002)　
○「術後甲状腺機能低下症に起因する鬱状態における脳血流変化に関する研究」(2000-2002)　
○「脳内神経伝達機能の画像診断を可能にする新規放射性診断薬の開発に関する研究」(1999-2001)　
○「脳内ドーパミン神経機能診断を目的とする放射性診断薬の開発と診断法の確立」(1998-1999)　
○「癌の免疫核医学診断・治療を目的とする腫瘍部位解裂性ヨウ素標識試薬の開発」(1997-1999)　
○「脳内神経伝達機能の画像診断を目的とした放射性診断薬の開発に関する基礎研究」(1996-1996)　
○「脳内アミノ酸代謝機能の画像診断を目的とした放射性診断薬の開発に関する基礎研究」(1994-1994)　

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

○Radiopharmaceutical Science B(2023)
○Radioisotope in In-Vitro and In-Vivo Techniques(2023)
○Radiation Protection and Safety Experiment(2023)
○Basic Radiation Biology(2023)
○Radiopharmaceutical Science A(2023)
○Radioisotope in In-Vitro and In-Vivo Techniques(2023)
○Radiation Protection and Safety Experiment(2023)
○Radiation Hygiene and Safety Management(2023)
○Laws and Regulations Related to Radiation(2023)
○Analytical Methods in Clinical Chemistry(2023)
○Radiation Hygiene and Safety Management(2023)
○Laws and Regulations Related to Radiation(2023)
○Radioisotope in In-Vitro and In-Vivo Techniques(2022)
○Radiation Biology(2022)
○Radiopharmaceutical Science(2022)
○Radiation Protection and Safety Experiment(2022)
○Radiopharmaceutical Science(2022)
○Radioisotope in In-Vitro and In-Vivo Techniques(2022)
○Radiation Biology(2022)
○Radiation Protection and Safety Experiment(2022)
○Radiation Hygiene and Safety Management(2022)
○Laws and Regulations Related to Radiation(2022)
○Analytical Methods in Clinical Chemistry(2022)
○Radiation Hygiene and Safety Management(2022)
○Laws and Regulations Related to Radiation(2022)
○Analytical Methods in Clinical Chemistry(2022)
○Radiobiology(2021)
○Radiopharmaceutical Science(2021)
○Radioisotope in In-Vitro and In-Vivo Techniques(2021)
○Radiation Protection and Safety Experiment(2021)
○Radiation Hygiene and Safety Management(2021)
○Laws and Regulations Related to Radiation(2021)
○Analytical Methods in Clinical Chemistry(2021)

Classes (Graduate Schools)

○Processing & Anal. for Biofunctional Imaging: Res.(2017)
○Analytics for Physical Function: Lecture(2017)
○Analytics for Functional Imaging: Lecture(2017)
○Analytics for Functional Imaging: Seminar(2017)
○Analytics for Functional Imaging: Research(2017)
○Research Design in Medical Radiation Science: Lec.(2017)
○Analytics for Physical Function: Seminar(2017)
○Processing & Anal. for Biofunctional Imaging: Res.(2016)
○Analytics for Physical Function: Seminar(2016)
○Research Design in Medical Radiation Science: Lec.(2016)
○Research Design in Health Science: Lecture(2016)
○Analytics for Physical Function: Lecture(2016)
○Molecular Medical Oncology(2016)
○Analytics for Functional Imaging: Research(2016)
○Analytics for Functional Imaging: Lecture(2016)
○Analytics for Functional Imaging: Seminar(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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