Associate Professor KATAGIRI Takamasa
Faculty, Affiliation
Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences
College and School Educational Field
Division of Health Sciences, Graduate School of Medical Science
Division of Health Sciences，Graduate School of Medical Science
Laboratory
Academic Background
【Degree】
Ph.D.
Career
金沢大学医薬保健研究域病態検査学講座 准教授
金沢大学医薬保健研究域病態検査学講座 助教
金沢大学医学部細胞移植学講座
Year & Month of Birth
Academic Society
Award
Specialities
Immunology、Hematology
Speciality Keywords
Idiopathic aplastic anemia, bone marrow failure syndrome, MDS, leukemia, autoimnune disease, imnunodeficiency disease, HSPC differentiation, bone marrow environment, genomics, mouse model bone marrow transplantation.
Research Themes
自己免疫性造血器疾患の病態解明および新規検査法・治療法の確立
患者iPS細胞とBRGSを用いた特異的表現型を有する患者造血マウスモデルの創出
患者造血における時間的・空間的造血制御変容の解明
Books
Papers
- Frequent loss of HLA-B*40:02 from leucocytes in male patients with hepatitis-associated aplastic anaemia British Journal of Haematology 2024
- Characterizing hematopoiesis in autoimmune bone marrow failure through patient-derived iPS cells Bio clinica 39 11 96-98 2024
- Insights into clonal hematopoiesis and somatic loss of HLA class I allele in autoimmune bone marrow failure Precision Medicine 7 7 551-553 2024
- A case of hepatitis-associated aplastic anemia following living-donor liver transplantation for fulminant hepatitis showing loss of heterozygosity in the 6p chromosome in the affected liver British Journal of Haematology 204 2 623-627 2024
- Elucidation of the characteristics of hematopoietic stem progenitor cells with malignant tumor-related gene mutations using iPS cells derived from patients with autoimmune bone marrow failure Bio clinica 38 4 37-39 2023
- HLA class I allele loss and bone marrow transplantation outcomes in immune aplastic anemia Transplantation and Cellular Therapy 30 3 281.e1-281.e13. 2023
- Familial immune-mediated aplastic anaemia in six different families eJHaem 4 3 714-718 2023
- Frequent HLA-DR loss on hematopoietic stem progenitor cells in patients with cyclosporine-dependent aplastic anemia carrying HLA-DR15 Leukemia 36 6 1666-1675 2022
- The GPI-anchored protein CD109 protects hematopoietic progenitor cells from undergoing erythroid differentiation induced by TGF-β Leukeima 36 3 847-855 2022
- Clonal hematopoiesis by SLIT1-mutated hematopoietic stem cells due to a breakdown of the autocrine loop involving Slit1 in acquired aplastic anemia. Leukemia 2019/11
- Kampo medicine for Frailty as Kidney deficiency. 3 2 142 2019
- Sustained clonal hematopoiesis by HLA-lacking hematopoietic stem cells without driver mutations in aplastic anemia. Blood Adv 2 9 1000-1012 2018/05
- Paroxysmal nocturnal hemoglobinuria induced by the occurrence of BCR-ABL in a PIGA mutant hematopoietic progenitor cell Leukemia 30 5 1208-1210 2016/05
- Cyclosporine restores hematopoietic function by compensating for decreased Tregs in patients with pure red cell aplasia and acquired aplastic anemia. Ann Hematol 95 5 771-781 2016/04
- Increased glycosylphosphatidylinositol-anchored protein-deficient granulocytes define a benign subset of bone marrow failures in patients with trisomy 8. Eur J Haematol. 95 3 230-238 2015/09
- Pathological and clinical significance of leukocyte lacking HLAs in patients with acquired aplastic anemia 59 6 658-665 2013/06
- Individual hematopoietic stem cells in human bone marrow of patients with aplastic anemia or myelodysplastic syndrome stably give rise to limited cell lineages. STEM CELLS 31 3 536-46 2013/03
- Immunologically escaped hematopoiesis caused by HLA allelic loss in patients with aplastic anemia]. 53 7 651-7 2012/07
- Favorable outcome of patients who have 13q deletion: a suggestion for revision of the WHO 'MDS-U' designation. Haematologica 97 12 1845-1849 2012/12
- Frequent loss of HLA alleles associated with copy number-neutral 6pLOH in acquired aplastic anemia. Blood 118 25 6601-6609 2011/09
- Sustained trilineage hematopoietic recovery in a patient with refractory anemia, del(13)(q12q22), and paroxysmal nocturnal hemoglobinuria-type cells treated with immunosuppressive therapy. Leuk Res. 35 9 147 2011/09
- GPI-anchored protein-deficient T cells in patients with aplastic anemia and low-risk myelodysplastic syndrome: implications for the immunopathophysiology of bone marrow failure. Eur J Haematol. 86 3 226-36 2011/03
- Biased usage of BV gene families of T-cell receptors of WT1 (Wilms' tumor gene)-specific CD8+ T cells in patients with myeloid malignancies. Cancer Sci 101 3 594-600 2010/03
- Identification of a WT1 protein-derived peptide, WT1, as a HLA-A 0206-restricted, WT1-specific CTL epitope. Microbiol Immunol 52 11 551-8 2008/11
- Mismatch of minor histocompatibility antigen contributes to a graft-versus-leukemia effect rather than to acute GVHD, resulting in long-term survival after HLA-identical stem cell transplantation in Japan. Bone Marrow Transplant 38 10 681-6 2006/11
Conference Presentations
Others
Arts and Fieldwork
Patent
Theme to the desired joint research
Grant-in-Aid for Scientific Research
○「自己免疫性骨髄不全症患者iPS細胞を用いた疾患モデルの創出と選択的造血制御の解明」(2023-2026)
○「自己免疫性造血不全における新たな免疫回避機構による造血制御変容の基盤的解明」(2020-2022)
○「iPS細胞由来ヒト造血幹細胞を用いた自己免疫性造血不全の発症機序の解明」(2017-2019)
○「治療関連骨髄性腫瘍の疫学的、分子生物学的研究」(2016-2018)
○「新学術領域研究ゲノム支援」(2015-2016)
○「発作性夜間血色素尿症（PNH）形質を利用したヒト造血幹細胞動態の解明」(2014-2016)
○「HLAアレル欠失現象を利用したヒト造血幹細胞制御分子の同定」(2012-2013)
○「HLAアレル欠失現象を利用したヒト造血幹細胞制御分子の同定」(2012-2013)
Competitive research funding,Contribution
Collaborative research,Consignment study
Classes (Bachelors)
○Immunology(2024)
○Introduction to Region-studies(2024)
○Practical Course in Laboratory of Serology and Immunology(2024)
○Public Health(2024)
○Laboratory Medicine of Blood Transfusion(2024)
○Clinial Practice of Hematology and Blood Transfusion(2024)
○Practical Course in Laboratory of Serology and Immunology(2023)
○Clinial Practice of Hematology and Blood Transfusion(2023)
○Introduction to Region-studies(2023)
○Laboratory Medicine of Blood Transfusion(2023)
○Immunology(2023)
○Laboratory of Serology and Immunology(2023)
○Public Health(2023)
○Clinial Practice of Hematology and Blood Transfusion(2022)
○Introduction to Region-studies(2022)
○Immunology(2022)
○Practical Course in Laboratory of Serology and Immunology(2022)
○Laboratory Medicine of Blood Transfusion(2022)
○Laboratory of Serology and Immunology(2022)
○Hematology(2022)
○Public Health(2022)
○Clinial Practice of Hematology and Blood Transfusion(2021)
○Laboratory of Serology and Immunology(2021)
○Practical Course in Laboratory of Serology and Immunology(2021)
○Public Health(2021)
○Immunology(2021)
○Hematology(2021)
○Laboratory Medicine of Blood Transfusion(2021)
○Laboratory Medicine of Blood Transfusion(2020)
○Public Health(2020)
○Introduction to Region-studies(2020)
○Clinial Practice of Hematology and Blood Transfusion(2020)
○Immunology(2020)
○Introduction to Region-studies(2020)
○Practical Course in Laboratory of Serology and Immunology(2020)
○Laboratory of Serology and Immunology(2020)
○Practice for Histology(2020)
○Introduction to Region-studies(2020)
○Hematology(2020)
○Introduction to Region-studies(2019)
○Immunology(2019)
○Clinial Practice of Hematology and Blood Transfusion(2019)
○Public Health(2019)
○Practice for Histology(2019)
○Practical Course in Laboratory of Serology and Immunology(2019)
○Laboratory of Serology and Immunology(2019)
○Laboratory Medicine of Blood Transfusion(2019)
○Hematology(2019)
○Practical Course in Laboratory of Serology and Immunology(2018)
○Practice for Histology(2018)
○Laboratory of Serology and Immunology(2018)
○Hematology(2018)
○Laboratory Medicine of Blood Transfusion(2018)
○Immunology(2018)
○Clinial Practice of Hematology and Blood Transfusion(2018)
○Introduction to Region-studies(2018)
○Laboratory of Serology and Immunology(2017)
○Laboratory Medicine of Blood Transfusion(2017)
○Practice for Histology(2017)
○Introduction to Region-studies(2017)
○Practical Course in Laboratory of Serology and Immunology(2017)
○Clinial Practice of Hematology and Blood Transfusion(2017)
○Immunology(2017)
○Practice for Histology(2016)
○Laboratory Medicine of Blood Transfusion(2016)
○Laboratory of Serology and Immunology(2016)
○Immunology(2016)
○Experimental Course in Physiology(2016)
○Clinial Practice of Hematology and Blood Transfusion(2016)
○Practical Course in Laboratory of Serology and Immunology(2016)
Classes (Graduate Schools)
○Advanced Laboratory Oncology: Research(2024)
○腫瘍検査学特講演習(2024)
○Laboratory Oncology: Lecture(2024)
○Laboratory Oncology: Research(2024)
○Clinical Immunohematology: Seminar(2024)
○Clinical Immunohematology: Lecture(2024)
○An Introduction to Medical Laboratory Sciences:Lec(2024)
○Advanced Laboratory Oncology: Research(2023)
○腫瘍検査学特講演習(2023)
○Laboratory Oncology: Lecture(2023)
○Laboratory Oncology: Research(2023)
○Clinical Immunohematology: Seminar(2023)
○Clinical Immunohematology: Lecture(2023)
○An Introduction to Medical Laboratory Sciences:Lec(2023)
○腫瘍検査学特別研究(2022)
○腫瘍検査学特講演習(2022)
○腫瘍検査学特講(2022)
○腫瘍検査学課題研究(2022)
○An Introduction to Medical Laboratory Sciences:Lec(2022)
○Clinical Immunohematology: Lecture(2022)
○Clinical Immunohematology: Seminar(2022)
○An Introduction to Medical Laboratory Sciences:Lec(2021)
○Clinical Immunohematology: Lecture(2021)
○Clinical Immunohematology: Seminar(2021)
○An Introduction to Medical Laboratory Sciences:Lec(2020)
○Clinical Immunohematology: Lecture(2020)
○Clinical Immunohematology: Seminar(2020)
○Clinical Immunohematology: Lecture(2019)
○An Introduction to Medical Laboratory Sciences:Lec(2019)
○Clinical Immunohematology: Seminar(2019)
○Clinical Immunohematology: Lecture(2018)
○An Introduction to Medical Laboratory Sciences:Lec(2018)
○Clinical Immunohematology: Seminar(2018)
○Clinical Immunohematology: Seminar(2017)
○An Introduction to Medical Laboratory Sciences:Lec(2017)
○Clinical Immunohematology: Lecture(2017)
○An Introduction to Medical Laboratory Sciences:Lec(2016)