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Researcher Information

last modified：2024/11/22

Professor　KIMURA, Hiroyuki

Mail Laboratory Website

Faculty, Affiliation

Research Center for Experimental Modeling of Human Disease

College and School Educational Field

Division of Medical Sciences, Graduate School of Medical Science
Division of Medicine, Graduate School of Medical Science

Laboratory

Division of Probe Chemistry for Disease Analysis/Central Institute for Radioisotope Science　TEL:076-265-2470　FAX:076-234-4245

Academic Background

Career

Year & Month of Birth

Academic Society

The Japanese Peptide Society
JAPANESE SOCIETY OF NUCLEAR MEDICINE
THE JAPAN SOCIETY FOR ANALYTICAL CHEMISTRY
Japan Radioisotope Association

THE CHEMICAL SOCIETY OF JAPAN
THE SOCIETY OF FLUORINE CHEMISTRY, JAPAN
THE PHARMACEUTICAL SOCIETY OF JAPAN
Society of Nuclear Medicine and Molecular Imaging



Award

Specialities

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Speciality Keywords

Research Themes

Books

  • 　Handbook of In Vivo Chemistry in Mice: From Lab to Living System　Wiley VCH　2020/02

Papers

  • 　Preparation and evaluation of Re-186/188-labeled antibody (A7) for radioimmunotherapy with rhenium(I) tricarbonyl core as a chelate site　Kazuma Ogawa,Hidekazu Kawashima,Seigo Kinuya,Kazuhiro Shiba,Masahisa Onoguchi,Hiroyuki Kimura,Kazuyuki Hashimoto,Akira Odani,Hideo Saji　ANNALS OF NUCLEAR MEDICINE　23　10　843　2009/12
  • 　Imaging Reagents Study for Nuclear Medicine Using an Electron-Tracking Compton Gamma-Ray Camera　Shigeto Kabuki,Hiroyuki Kimura,Hiroo Amano,Yuji Nakamoto,Hidetoshi Kubo,Kentaro Miuchi,Shunsuke Kurosawa,Michiaki Takahashi,Hidekazu Kawashima,Masashi Ueda,Tomohisa Okada,Koichi Ogawa,Kaori Togashi,Hideo Saji,Toru Tanimori　2009 IEEE NUCLEAR SCIENCE SYMPOSIUM CONFERENCE RECORD, VOLS 1-5　2813　2009
  • 　Fluorinated Benzofuran Derivatives for PET Imaging of beta-Amyloid Plaques in Alzheimer's Disease Brains　Yan Cheng,Masahiro Ono,Hiroyuki Kimura,Shinya Kagawa,Ryuichi Nishii,Hidekazu Kawashima,Hideo Sajio　ACS MEDICINAL CHEMISTRY LETTERS　1　7　321　2010/10
  • 　Synthesis and evaluation of radioiodinated cyclooxygenase-2 inhibitors as potential SPECT tracers for cyclooxygenase-2 expression　Y Kuge,Y Katada,S Shimonaka,T Temma,H Kimura,Y Kiyono,C Yokota,K Minematsu,K Seki,N Tamaki,K Ohkura,H Saji　NUCLEAR MEDICINE AND BIOLOGY　33　1　21　2006/01
  • 　Synthesis and evaluation of a radioiodinated lumiracoxib derivative for the imaging of cyclooxygenase-2 expression　Yuji Kuge,Naoyuki Obokata,Hiroyuki Kimura,Yumiko Katada,Takashi Temma,Yukihiko Sugimoto,Kazuki Aita,Koh-ichi Seki,Nagara Tamaki,Hideo Saji　NUCLEAR MEDICINE AND BIOLOGY　36　8　869　2009/11

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  • 　Synthesis and evaluation of radioiodinated exendin derivatives for the imaging of GLP-1 receptor expression in pancreatic islets　Kimura Hiroyuki,Ogawa Yu,Kawashima Hidekazu,Mukai Eri,Toyoda Kentaro,Fujimoto Hiroyuki,Hirao Konomu,Ono Masahiro,Inagaki Nobuya,Saji Hideo　JOURNAL OF NUCLEAR MEDICINE　51　2010/05
  • 　A novel attractive interaction in the Diels-Alder reaction of N-protected pyrroles with allene-1,3-dicarboxylates　Kiyoharu Nishide,Shogo Ichihashi,Hiroyuki Kimura,Takahiro Katoh,Manabu Node　Tetrahedron Letters　42　52　9237　2001/12/24
  • 　Lipase-catalyzed asymmetric dealkoxylcarbonylation of sigma-symmetrical beta-ketodiesters and its application to the synthesis of (-)-podocarpic acid　T Katoh,K Awasaguchi,D Mori,H Kimura,T Kajimoto,M Node　SYNLETT　19　2919　2005/12
  • 　Development of a Electron Tracking Compton Gamma-Ray Camera Using a Gas Micro-Tracking Device for Nuclear Medicine　S. Kabuki,K. Hattori,H. Kawashima,H. Kimura,R. Kohara,A. Kubo,H. Kubo,S. Kurosawa,E. Kunieda,O. Miyazaki,T. Nagayoshi,T. Nakahara,T. Nakazawa,H. Nishimura,K. Ogawa,Y. Okada,R. Orito,H. Saji,H. Sekiya,T. Shirahata,A. Takada,T. Tanimori,M. Ueda,K. Ueno,E. Yamamoto　2006 IEEE NUCLEAR SCIENCE SYMPOSIUM CONFERENCE RECORD, VOL 1-6　2971　2006
  • 　Synthesis of (-)-epibatidine and its derivatives from chiral allene-1,3-dicarboxylate esters　H Kimura,T Fujiwara,T Katoh,K Nishide,T Kajimoto,M Node　CHEMICAL & PHARMACEUTICAL BULLETIN　54　3　399　2006/03
  • 　A novel F-18-labeled pyridyl benzofuran derivative for imaging of beta-amyloid plaques in Alzheimer's brains　Yan Cheng,Masahiro Ono,Hiroyuki Kimura,Shinya Kagawa,Ryuichi Nishii,Hideo Saji　BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　20　20　6141　2010/10
  • 　Advanced Compton Camera with the ability in electron tracking based on Micro Pixel Gas Detector for Medical Imaging　Toru Tanimori,Kaori Hattori,Shigeto Kabuki,Hidekazu Kawashima,Hiroyuki Kimura,Ryota Kohara,Etsuo Kunieda,Atsushi Kubo,Hidetoshi Kubo,Osamu Miyazaki,Kentaro Miuchi,Tadaki Nakahara,Tetsuo Nakazawa,Hironobu Nishimura,Koichi Ogawa,Yoko Okada,Reiko Orito,Hideo Saji,Hiroyuki Sekiya,Takashi Shirahata,Atsushi Takada,Masashi Ueda,Kazuki Ueno,Etsuji Yamamoto　2006 IEEE NUCLEAR SCIENCE SYMPOSIUM CONFERENCE RECORD, VOL 1-6　3870　2006
  • 　Synthesis and evaluation of radioiodinated (S,S)-2-(alpha-(2-iodophenoxy)benzyl)morpholine for imaging brain norepinephrine transporter　Naoki Kanegawa,Yasushi Kiyono,Hiroyuki Kimura,Taku Sugita,Satomi Kajiyama,Hidekazu Kawashima,Masashi Ueda,Yuji Kuge,Hideo Saji　EUROPEAN JOURNAL OF NUCLEAR MEDICINE AND MOLECULAR IMAGING　33　6　639　2006/06
  • 　Development of dual functional SPECT/fluorescent probes for imaging cerebral beta-amyloid plaques　Masahiro Ono,Manami Ishikawa,Hiroyuki Kimura,Shun Hayashi,Kenji Matsumura,Hiroyuki Watanabe,Yoichi Shimizu,Yan Cheng,Mengchao Cui,Hidekazu Kawashima,Hideo Saji　BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　20　13　3885　2010/07
  • 　Synthesis and Evaluation of Novel Chalcone Derivatives with Tc-99m/Re Complexes as Potential Probes for Detection of beta-Amyloid Plaques　Masahiro Ono,Ryoichi Ikeoka,Hiroyuki Watanbe,Hiroyuki Kimura,Takeshi Fuchigami,Mamoru Haratake,Hideo Saji,Mono Nakayama　ACS CHEMICAL NEUROSCIENCE　1　9　598　2010/09
  • 　Synthesis and evaluation of F-18 labeled peptidergic compound as a novel tumor peptide transporter imaging probe　Kawashima Hidekazu,Toshikawa Kae,Mori Daisuke,Kimura Hiroyuki,Ono Masahiro,Saji Hideo　JOURNAL OF NUCLEAR MEDICINE　51　2010/05
  • 　GLP-1 receptor antagonist as a potential probe for pancreatic beta-cell imaging　Eri Mukai,Kentaro Toyoda,Hiroyuki Kimura,Hidekazu Kawashima,Hiroyuki Fujimoto,Masashi Ueda,Takashi Temma,Konomu Hirao,Kenji Nagakawa,Hideo Saji,Nobuya Inagaki　BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　389　3　523　2009/11
  • 　Diagnostic approach of using an electron tracking Compton gamma-ray camera based on small animal and phantom experiments　S. Kabuki,K. Hattori,H. Kawashima,H. Kimura,R. Kohara,A. Kubo,H. Kubo,S. Kurosawa,E. Kunieda,K. Miuchi,O. Miyazaki,T. Nagayoshi,T. Nakahara,Y. Nakamoto,T. Nakazawa,H. Nishimura,K. Ogawa,T. Okada,Y. Okada,R. Orito,H. Saji,H. Sekiya,T. Shirahata,A. Takada,T. Tanimori,K. Togashi,M. Ueda,K. Ueno,E. Yamamoto　IEEE Nuclear Science Symposium Conference Record　5　3395　2007
  • 　A practical improvement of crystallization-induced asymmetric transformation of allene-1,3-dicarboxylates　Takahiro Katoh,Chie Noguchi,Hiroyuki Kimura,Toshio Fujiwara,Shogo Ichihashi,Kiyoharu Nishide,Tetsuya Kajimoto,Manabu Node　TETRAHEDRON-ASYMMETRY　17　20　2943　2006/11
  • 　Push-pull benzothiazole derivatives as probes for detecting beta-amyloid plaques in Alzheimer's brains　Masahiro Ono,Shun Hayashi,Hiroyuki Kimura,Hidekazu Kawashima,Morio Nakayama,Hideo Saji　BIOORGANIC & MEDICINAL CHEMISTRY　17　19　7002　2009/10
  • 　Imaging reagents study for nuclear medicine using an electron-tracking compton gamma-ray camera　Shigeto Kabuki,Hiroyuki Kimura,Hiroo Amano,Yuji Nakamoto,Hidetoshi Kubo,Kentaro Miuchi,Shunsuke Kurosawa,Michiaki Takahashi,Hidekazu Kawashima,Masashi Ueda,Tomohisa Okada,Koichi Ogawa,Kaori Togashi,Hideo Saji,Toru Tanimori　IEEE Nuclear Science Symposium Conference Record　2813　2009
  • 　Development of Electron Tacking Compton Camera based on Micro Pixel Gas Detector and its Application for Medical Imaging　F. T. Tanimori,H. Amano,K. Hattori,C. Ida,S. Iwaki,S. Kabuki,H. Kawashima,H. Kimura,R. Kohara,A. Kubo,H. Kubo,E. Kunieda,S. Kurosawa,K. Miuchi,O. Miyazaki,T. Nakazawa,T. Nakahara,Y. Nakamoto,H. Nishimura,K. Ogawa,T. Okada,Y. Okada,T. Shirahata,H. Saji,A. Takada,K. Togashi,K. Tsuchiya,M. Ueda,K. Ueno,E. Yamamoto　2008 IEEE NUCLEAR SCIENCE SYMPOSIUM AND MEDICAL IMAGING CONFERENCE (2008 NSS/MIC), VOLS 1-9　5530　2009
  • 　Fluoro-pegylated Chalcones as Positron Emission Tomography Probes for in Vivo Imaging of beta-Amyloid Plaques in Alzheimer's Disease　Masahiro Ono,Rumi Watanabe,Hidekazu Kawashima,Yan Cheng,Hiroyuki Kimura,Hiroyuki Watanabe,Mamoru Haratake,Hideo Saji,Morio Nakayama　JOURNAL OF MEDICINAL CHEMISTRY　52　20　6394　2009/10
  • 　Imaging Study of a Phantom and Small Animal with a Two-Head Electron-Tracking Compton Gamma-Ray Camera　Shigeto Kabuki,Hiroyuki Kimura,Hiroo Amano,Yuji Nakamoto,Hidetoshi Kubo,Kentaro Miuchi,Shunsuke Kurosawa,Michiaki Takahashi,Hidekazu Kawashima,Masashi Ueda,Tomohisa Okada,Koichi Ogawa,Kaori Togashi,Hideo Saji,Toru Tanimori　2010 IEEE NUCLEAR SCIENCE SYMPOSIUM CONFERENCE RECORD (NSS/MIC)　2844　2010
  • 　Synthesis and in vivo evaluation of Re-188-labeled antibody using rhenium(I) tricarbonyl complex　Hidekazu Kawashima,Kazuma Ogawa,Seigo Kinuya,Kazuhiro Shiba,Hiroyuki Kimura,Kazuyuki Hashimato,Hirofumi Mori,Hideo Saji　YAKUGAKU ZASSHI-JOURNAL OF THE PHARMACEUTICAL SOCIETY OF JAPAN　128　53　2008
  • 　Non-Invasive Imaging of Pancreatic Islets Targeting Glucagon-Like Peptide-1 Receptors　Eri Mukai,Kentaro Toyoda,Hiroyuki Fujimoto,Hiroyuki Kimura,Hidekazu Kawashima,Masashi Ueda,Takashi Temmma,Konomu Hirao,Kenji Nagakawa,Yutaka Seino,Hideo Saji,Nobuya Inagaki　DIABETES　58　A371　2009/06
  • 　Development of in vivo imaging agents targeting glucagon-like peptide-1 receptor (GLP-1R) in pancreatic islets　Kimura Hiroyuki,Ogawa Yu,Kawashima Hidekazu,Mukai Eri,Toyoda Kentaro,Fujimoto Hiroyuki,Hirao Konomu,Ono Masahiro,Inagaki Nobuya,Saji Hideo　JOURNAL OF NUCLEAR MEDICINE　50　2009/05
  • 　A novel radioiodinated hydroxyethylamine dipeptide isoster derivative as potential SPECT imaging probe for beta-secretase detection in Alzheimer's disease brain　Kawashima Hidekazu,Kawai Tomoki,Kimura Hiroyuki,Kuge Yuji,Ono Masahiro,Saji Hideo　JOURNAL OF NUCLEAR MEDICINE　50　2009/05
  • 　Non-Invasive PET Imaging of Pancreatic Islets Targeting Glucagon-Like Peptide-1 Receptors　Kentaro Toyoda,Hiroyuki Kimura,Eri Mukai,Yuu Ogawa,Hiroyuki Fujimoto,Masashi Ueda,Takashi Temma,Hidekazu Kawashima,Konomu Hirao,Hirokazu Matsuda,Kenji Nagakawa,Hideo Saji,Nobuya Inagaki　DIABETES　59　A431　2010/06
  • 　Technetium-99m Labeled Pyridyl Benzofuran Derivatives as Single Photon Emission Computed Tomography Imaging Probes for beta-Amyloid Plaques in Alzheimer's Brains　Yan Cheng,Masahiro Ono,Hiroyuki Kimura,Masashi Ueda,Hideo Saji　JOURNAL OF MEDICINAL CHEMISTRY　55　5　2279　2012/03
  • 　SU‐E‐I‐63: Performance Study of An Electron‐Tracking Compton Camera for Medical Imaging　S. Kabuki,H. Kimura,H. Kubo,K. Ogawa,E. Kunieda,T. Tanimori　Medical Physics　39　6　3639　2012
  • 　Rhodanine and Thiohydantoin Derivatives for Detecting Tau Pathology in Alzheimer's Brains　Masahiro Ono,Shun Hayashi,Kenji Matsumura,Hiroyuki Kimura,Yoko Okamoto,Masafumi Ihara,Ryosuke Takahashi,Hiroshi Mori,Hideo Saji　ACS CHEMICAL NEUROSCIENCE　2　5　269　2011/05
  • 　Pretargeted radioimmunotherapy of tumor using a novel radiorhenium-labeled biotin derivative and streptavidin conjugated anti-cytokeratin 19 monoclonal antibody　Kawashima Flidekazu,Hirasawa Makoto,Kimura Hiroyuki,Ono Masahiro,Hashimoto Kazuyuki,Saji Hideo　JOURNAL OF NUCLEAR MEDICINE　52　2011/05/01
  • 　F-18-Labeled Phenyldiazenyl Benzothiazole for in Vivo Imaging of Neurofibrillary Tangles in Alzheimer's Disease Brains　Kenji Matsumura,Masahiro Ono,Hiroyuki Kimura,Masashi Ueda,Yuji Nakamoto,Kaori Togashi,Yoko Okamoto,Masafumi Ihara,Ryosuke Takahashi,Hideo Saji　ACS MEDICINAL CHEMISTRY LETTERS　3　1　58　2012/01
  • 　Radiosynthesis and evaluation of F-18 exendin-4 derivatives as a PET tracer for the imaging of GLP-1 receptors on pancreatic beta-cells　Kimura Hiroyuki,Ogawa Yu,Kawashima Hidekazu,Toyoda Kentaro,Mukai Eri,Fujimoto Hiroyuki,Ono Masahiro,Hirao Konomu,Inagaki Nobuya,Saji Hideo　JOURNAL OF NUCLEAR MEDICINE　52　2011/05/01
  • 　Synthesis and evaluation of a radioiodinated trisaccharide derivative as a synthetic substrate for a sensitive N-acetylglucosaminyltransferase V radioassay　Takahiro Mukai,Masayori Hagimori,Kenji Arimitsu,Takahiro Katoh,Misa Ukon,Tetsuya Kajimoto,Hiroyuki Kimura,Yasuhiro Magata,Eiji Miyoshi,Naoyuki Taniguchi,Manabu Node,Hideo Saji　BIOORGANIC & MEDICINAL CHEMISTRY　19　14　4312　2011/07
  • 　Novel Benzofurans with Tc-99m Complexes as Probes for Imaging Cerebral beta-Amyloid Plaques　Masahiro Ono,Yasufumi Fuchi,Takeshi Fuchigami,Nobuya Kobashi,Hiroyuki Kimura,Mamoru Haratake,Hideo Saji,Morio Nakayama　ACS MEDICINAL CHEMISTRY LETTERS　1　8　443　2010/11
  • 　Electron-tracking Compton gamma-ray camera for small animal and phantom imaging　Shigeto Kabuki,Hiroyuki Kimura,Hiroo Amano,Yuji Nakamoto,Hidetoshi Kubo,Kentaro Miuchi,Shunsuke Kurosawa,Michiaki Takahashi,Hidekazu Kawashima,Masashi Ueda,Tomohisa Okada,Atsushi Kubo,Etuso Kunieda,Tadaki Nakahara,Ryota Kohara,Osamu Miyazaki,Tetsuo Nakazawa,Takashi Shirahata,Etsuji Yamamoto,Koichi Ogawa,Kaori Togashi,Hideo Saji,Toru Tanimori　NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT　623　1　606　2010/11
  • 　One-Flow Synthesis of [F-18]SFB Using Fully Automated Microreactor-based Continuous Flow System　Hiroyuki Kimura,Hidekazu Saiki,Ren Iwata,Eiichi Ozeki,Masahiro Ono,Hideo Saji　JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS　54　S557　2011
  • 　Radiosynthesis and evaluation of [F-18]Mitiglinide derivatives as PET tracers for sulfonylurea receptor in pancreatic islets　Hirokazu Matsuda,Hiroyuki Kimura,Yu Ogawa,Hidekazu Kawashima,Kentaro Toyoda,Eri Mukai,Hiroyuki Fujimoto,Hiroshi Nakamura,Konomu Hirao,Masahiro Ono,Nobuya Inagaki,Hideo Saji　JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS　54　S510　2011
  • 　Novel quinoxaline derivatives for in vivo imaging of beta-amyloid plaques in the brain　Mengchao Cui,Masahiro Ono,Hiroyuki Kimura,Boli Liu,Hideo Saji　BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　21　14　4193　2011/07
  • 　Development of Non-Invasive PET Probe for Quantifying Pancreatic beta-Cell Mass Using Fluorine-18-Labeled Exendin-4　Toyoda Kentaro,Kimura Hiroyuki,Fujimoto Hiroyuki,Zhuang Xiaotong,Mukai Eri,Ogawa Yuu,Hirao Konomu,Matsuda Hirokazu,Kawashima Hidekazu,Ueda Masashi,Temma Takashi,Saji Hideo,Inagaki Nobuya　DIABETES　60　A482　2011/07/01
  • 　Non-Invasive SPECT Imaging of Pancreatic Islets Targeting Glucagon-Like Peptide-1 Receptors　Fujimoto Hiroyuki,Toyoda Kentaro,Kimura Hiroyuki,Ogawa Yuu,Mukai Eri,Zhuang Xiaotong,Kawashima Hidekazu,Matsuda Hirokazu,Hirao Konomu,Saji Hideo,Inagaki Nobuya　DIABETES　60　A479　2011/07/01
  • 　Effective synthesis of 99mTc tricarbonyl complexes by microwave heating　Naoya Harada,Hiroyuki Kimura,Masahiro Ono,Daisuke Mori,Yoshiro Ohmomo,Tetsuya Kajimoto,Hidekazu Kawashima,Hideo Saji　Journal of Organometallic Chemistry　696　23　3745　2011/11/15
  • 　Synthesis and biological evaluation of indole-chalcone derivatives as beta-amyloid imaging probe　Mengchao Cui,Masahiro Ono,Hiroyuki Kimura,Bo Li Liu,Hideo Saji　BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　21　3　980　2011/02
  • 　Synthesis and biological evaluation of novel oxindole derivatives for imaging neurofibrillary tangles in Alzheimer's disease　Hiroyuki Watanabe,Masahiro Ono,Hiroyuki Kimura,Kenji Matsumura,Masashi Yoshimura,Yoko Okamoto,Masafumi Ihara,Ryosuke Takahashi,Hideo Saji　BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　22　17　5700　2012/09
  • 　Tc-99m/Re complexes based on flavone and aurone as SPECT probes for imaging cerebral beta-amyloid plaques　Masahiro Ono,Ryoichi Ikeoka,Hiroyuki Watanabe,Hiroyuki Kimura,Takeshi Fuchigami,Mamoru Haratake,Hideo Saji,Morio Nakayama　BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　20　19　5743　2010/10
  • 　Synthesis and evaluation of benzofuran-2-yl(phenyl)methanone derivatives as ligands for beta-amyloid plaques　Mengchao Cui,Masahiro Ono,Hiroyuki Kimura,Boli Liu,Hideo Saji　BIOORGANIC & MEDICINAL CHEMISTRY　19　13　4148　2011/07
  • 　Phenyldiazenyl benzothiazole derivatives as probes for in vivo imaging of neurofibrillary tangles in Alzheimer's disease brains　Kenji Matsumura,Masahiro Ono,Shun Hayashi,Hiroyuki Kimura,Yoko Okamoto,Masafumi Ihara,Ryosuke Takahashi,Hiroshi Mori,Hideo Saji　MEDCHEMCOMM　2　7　596　2011/07
  • 　Effective encapsulation of a new cationic gadolinium chelate into apoferritin and its evaluation as an MRI contrast agent　Akira Makino,Hiroshi Harada,Tomohisa Okada,Hiroyuki Kimura,Hiroo Amano,Hideo Saji,Masahiro Hiraoka,Shunsaku Kimura　NANOMEDICINE-NANOTECHNOLOGY BIOLOGY AND MEDICINE　7　5　638　2011/10
  • 　A dual fluorinated and iodinated radiotracer for PET and SPECT imaging of beta-amyloid plaques in the brain　Hiroyuki Watanabe,Masahiro Ono,Hiroyuki Kimura,Shinya Kagawa,Ryuichi Nishii,Takeshi Fuchigami,Mamoru Haratake,Morio Nakayama,Hideo Saji　BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　21　21　6519　2011/11
  • 　Development of I-123 labeled Exendin derivatives for the imaging of GLP-1 receptors on pancreatic beta-cell with SPECT　Ogawa Yu,Kimura Hiroyuki,Kawashima Hidekazu,Toyoda Kentaro,Mukai Eri,Fujimoto Hiroyuki,Hirao Konomu,Ono Masahiro,Inagaki Nobuya,Saji Hideo　JOURNAL OF NUCLEAR MEDICINE　52　2011/05/01
  • 　Concise site-specific synthesis of DTPA-peptide conjugates: Application to imaging probes for the chemokine receptor CXCR4　Ryo Masuda,Shinya Oishi,Hiroaki Ohno,Hiroyuki Kimura,Hideo Saji,Nobutaka Fujii　BIOORGANIC & MEDICINAL CHEMISTRY　19　10　3216　2011/05
  • 　Synthesis and Structure-Affinity Relationships of Novel Dibenzylideneacetone Derivatives as Probes for beta-Amyloid Plaques　Mengchao Cui,Masahiro Ono,Hiroyuki Kimura,Boli Liu,Hideo Saji　JOURNAL OF MEDICINAL CHEMISTRY　54　7　2225　2011/04
  • 　Novel F-18-Labeled Benzofuran Derivatives with Improved Properties for Positron Emission Tomography (PET) Imaging of beta-Amyloid Plaques in Alzheimer's Brains　Masahiro Ono,Yan Cheng,Hiroyuki Kimura,Mengchao Cui,Shinya Kagawa,Ryuichi Nishii,Hideo Saji　JOURNAL OF MEDICINAL CHEMISTRY　54　8　2971　2011/04
  • 　Development of a radioiodinated trisaccharide derivative as a synthetic substrate for sensitive N-acetylglucosaminyltransferase V radioassay　Takahiro Mukai,Masayori Hagimori,Kenji Arimitsu,Takahiro Katoh,Misa Ukon,Tetsuya Kajimoto,Hiroyuki Kimura,Yasuhiro Magata,Eiji Miyoshi,Naoyuki Taniguchi,Manabu Node,Hideo Saji　JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS　54　S199　2011
  • 　Development of I-123-labeled exendin derivative binding to GLP-1 receptors for imaging insulinoma by SPECT　Matsuda Hirokazu,Kimura Hiroyuki,Ogawa Yu,Takagi Mikako,Kon Asami,Ono Masahiro,Toyoda Kentaro,Inagaki Nobuya,Saji Hideo　JOURNAL OF NUCLEAR MEDICINE　53　2012/05/01
  • 　BODIPY-Based Molecular Probe for Imaging of Cerebral beta-Amyloid Plaques　Masahiro Ono,Hiroyuki Watanabe,Hiroyuki Kimura,Hideo Saji　ACS CHEMICAL NEUROSCIENCE　3　4　319　2012/04
  • 　ALTERNATIVE SYNTHESIS OF RADIOIODINATED TRISACCHARIDE DERIVATIVES, 2-(4-(IODOPHENY)-I-125)ETHYL 2-ACETAMIDO-2-DEOXY-beta-D-GLUCOPYRANOSYL-(1 -> 2)-alpha-D-MANNOPYRANOSYL-(1 -> 6)-beta-D-GLUCOPYRANOSIDE, AND PREPARATION OF ITS ANALOGS HAVING DIFFERENT LENGTHS OF ALKYL CHAINS INSTEAD OF ETHYL GROUP: ACCEPTOR SUBSTRATES OF N-ACETYLGLUCOSAMINYLTRANSFERASE V FOR IN VIVO IMAGING　Kenji Arimitsu,Tetsuya Kajimoto,Hiroyuki Kimura,Masahiro Ono,Minoru Ozeki,Manabu Node,Yoshiro Ohmomo,Hideo Saji,Masayuki Yamashita　HETEROCYCLES　83　12　2779　2011/12
  • 　Microwave-Assisted Synthesis of Organometallic Complexes of Tc-99m(CO)(3) and Re(CO)(3): Its Application to Radiopharmaceuticals　Hiroyuki Kimura,Daisuke Mori,Naoya Harada,Masahiro Ono,Yoshiro Ohmomo,Tetsuya Kajimoto,Hidekazu Kawashima,Hideo Saji　CHEMICAL & PHARMACEUTICAL BULLETIN　60　1　79　2012/01
  • 　Radioiodinated benzimidazole derivatives as single photon emission computed tomography probes for imaging of beta-amyloid plaques in Alzheimer's disease　Mengchao Cui,Masahiro Ono,Hiroyuki Kimura,Hidekazu Kawashima,Bo Li Liu,Hideo Saji　NUCLEAR MEDICINE AND BIOLOGY　38　3　313　2011/04
  • 　Novel F-18-Labeled Benzoxazole Derivatives as Potential Positron Emission Tomography Probes for Imaging of Cerebral beta-Amyloid Plaques in Alzheimer's Disease　Mengchao Cui,Masahiro Ono,Hiroyuki Kimura,Masashi Ueda,Yuji Nakamoto,Kaori Togashi,Yoko Okamoto,Masafumi Ihara,Ryosuke Takahashi,Boli Liu,Hideo Saji　JOURNAL OF MEDICINAL CHEMISTRY　55　21　9136　2012/11
  • 　Development of infection/inflammation PET imaging probe for diagnosis of diabetic foot: Synthesis and evaluation of [F-18]formyl-Met-Leu-Phe derivatives　Kimura Hiroyuki,Yamauchi Saki,Ono Masahiro,Kawashima Hidekazu,Saji Hideo　JOURNAL OF NUCLEAR MEDICINE　53　2012/05/01
  • 　Development of In-111-labeled Exendin-4 derivative for the imaging of glucagon-like peptide-1 receptor expression in pancreatic islets　Hiroyuki Kimura,Kaori Kambe,Hirokazu Matsuda,Kentaro Toyoda,Hiroyuki Fujimoto,Masahiro Ono,Nobuya Inagaki,Hideo Saji　JOURNAL OF NUCLEAR MEDICINE　55　2014/05
  • 　Smart Near-Infrared Fluorescence Probes with Donor-Acceptor Structure for in Vivo Detection of beta-Amyloid Deposits　Mengchao Cui,Masahiro Ono,Hiroyuki Watanabe,Hiroyuki Kimura,Boli Liu,Hideo Saji　JOURNAL OF THE AMERICAN CHEMICAL SOCIETY　136　9　3388　2014/03
  • 　ETCCを用いた核医学用RIトレーサーイメージング　谷森達,園田真也,奈部谷章,株木重人,木村寛之,窪秀利,澤野達哉,松岡佳大,古村翔太郎,高田淳史,上田真史,佐治英郎　Biomed Res Trace Elem　24　2　77　2013
  • 　The Performance Evaluation of the Electron Tracking Compton Camera　S. Sonoda,H. Kubo,T. Sawano,Y. Matsuoka,S. Komura,S. Nakamura,Y. Mizumura,T. Mizumoto,S. Kabuki,H. Kimura,A. Takada,T. Tanimori　2013 IEEE NUCLEAR SCIENCE SYMPOSIUM AND MEDICAL IMAGING CONFERENCE (NSS/MIC)　2013
  • 　Synthesis and characterization of novel styrylbenzimidazole and benzoimidazopyrimidine derivatives as probes for in vivo imaging of cerebral neurofibrillary tangles　Kenji Matsumura,Masahiro Ono,Masashi Yoshimura,Hiroyuki Watanabe,Hiroyuki Kimura,Yoko Okamoto,Masafumi Ihara,Ryosuke Takahashi,Hideo Saji　JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS　56　S57　2013/05
  • 　Cover Picture: Plasma Process. Polym. 12∕2015　Masashi Ueda,Daiki Yamagami,Keiko Watanabe,Asami Mori,Hiroyuki Kimura,Kohei Sano,Hideo Saji,Kenji Ishikawa,Masaru Hori,Hajime Sakakita,Yuzuru Ikehara,Shuichi Enomoto　Plasma Processes and Polymers　12　12　1329　2015　
  • 　Regulation of F-18-FDG Accumulation in Colorectal Cancer Cells with Mutated KRAS　Masayoshi Iwamoto,Kenji Kawada,Yuji Nakamoto,Yoshiro Itatani,Susumu Inamoto,Kosuke Toda,Hiroyuki Kimura,Takehiko Sasazuki,Senji Shirasawa,Hiroaki Okuyama,Masahiro Inoue,Suguru Hasegawa,Kaori Togashi,Yoshiharu Sakai　JOURNAL OF NUCLEAR MEDICINE　55　12　2038　2014/12
  • 　Synthesis and biological evaluation of I-123-labeled pyridyl benzoxazole derivatives: novel beta-amyloid imaging probes for single-photon emission computed tomography　Hiroyuki Watanabe,Masahiro Ono,Shimpei Iikuni,Hiroyuki Kimura,Yoko Okamoto,Masafumi Ihara,Hideo Saji　RSC ADVANCES　5　2　1009　2015
  • 　Synthesis and evaluation of a radioiodinated peptide probe targeting alpha v beta 6 integrin for the detection of pancreatic ductal adenocarcinoma　Masashi Ueda,Takahiro Fukushima,Kei Ogawa,Hiroyuki Kimura,Masahiro Ono,Takashi Yamaguchi,Yuzuru Ikehara,Hideo Saji　BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　445　3　661　2014/03
  • 　The synthesis of [F-18]pitavastatin as a tracer for hOATP using the Suzuki coupling　Yusuke Yagi,Hiroyuki Kimura,Kenji Arimitsu,Masahiro Ono,Kazuya Maeda,Hiroyuki Kusuhara,Tetsuya Kajimoto,Yuichi Sugiyama,Hideo Saji　ORGANIC & BIOMOLECULAR CHEMISTRY　13　4　1113　2015
  • 　Production of Tc-95m for Compton camera imaging　Yuichi Hatsukawa,Kazuyuki Hashimoto,Kazuaki Tsukada,Tetsuya Sato,Masato Asai,Atsushi Toyoshima,Yasuki Nagai,Toru Tanimori,Shinya Sonoda,Shigeto Kabuki,Hideo Saji,Hiroyuki Kimura　JOURNAL OF RADIOANALYTICAL AND NUCLEAR CHEMISTRY　303　2　1283　2015/02
  • 　Enhancement of Binding Affinity for Amyloid Aggregates by Multivalent Interactions of Tc-99m-Hydroxamamide Complexes　Shimpei Iikuni,Masahiro Ono,Hiroyuki Watanabe,Kenji Matsumura,Masashi Yoshimura,Naoya Harada,Hiroyuki Kimura,Morio Nakayama,Hideo Saji　MOLECULAR PHARMACEUTICS　11　4　1132　2014/04
  • 　Development of novel 123I-labeled pyridyl benzofuran derivatives for SPECT imaging of β-amyloid plaques in Alzheimer's disease.　Masahiro Ono,Yan Cheng,Hiroyuki Kimura,Hiroyuki Watanabe,Kenji Matsumura,Masashi Yoshimura,Shimpei Iikuni,Yoko Okamoto,Masafumi Ihara,Ryosuke Takahashi,Hideo Saji　PloS one　8　9　e74104　2013
  • 　SU‐C‐144‐01: Imaging Study of An Electron‐Tracking Compton Camera for Nuclear Medicine　S. Kabuki,S. Sonoda,Y. Hatsukawa,H. Kimura,M. Asai,K. Hashimoto,S. Komura,H. Kubo,Y. Matsuoka,T. Mizumoto,Y. Nagai,S. Nakamura,T. Sato,T. Sawano,A. Takada,A. Toyoshima,K. Tsukada,E. Kunieda,T. Tanimori　Medical Physics　40　6　98　2013
  • 　Synthesis and evaluation of I-123-labeled pyridyl benzofuran derivatives for SPECT imaging of - amyloid plaques in Alzheimer's disease　Ono Masahiro,Cheng Yan,Watanabe Hiroyuki,Iikuni Shinpei,Kimura Hiroyuki,Saji Hideo　JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS　56　S316　2013/05
  • 　Synthesis and biological evaluation of novel styryl benzimidazole derivatives as probes for imaging of neurofibrillary tangles in Alzheimer's disease.　Kenji Matsumura,Masahiro Ono,Masashi Yoshimura,Hiroyuki Kimura,Hiroyuki Watanabe,Yoko Okamoto,Masafumi Ihara,Ryosuke Takahashi,Hideo Saji　Bioorganic & medicinal chemistry　21　11　3356　2013/06/01
  • 　Structure-Activity Relationships and in Vivo Evaluation of Quinoxaline Derivatives for PET Imaging of beta-Amyloid Plaques　Masashi Yoshimura,Masahiro Ono,Kenji Matsurnura,Hiroyuki Watanabe,Hiroyuki Kimura,Mengchao Cui,Yuji Nakamoto,Kaori Togashi,Yoko Okamoto,Masafumi Ihara,Ryosuke Takahashi,Hideo Saji　ACS MEDICINAL CHEMISTRY LETTERS　4　7　31　2013/07
  • 　Molecular Imaging of beta-Amyloid Plaques with Near-Infrared Boron Dipyrromethane (BODIPY)-Based Fluorescent Probes　Hiroyuki Watanabe,Masahiro Ono,Kenji Matsumura,Masashi Yoshimura,Hiroyuki Kimura,Hideo Saji　MOLECULAR IMAGING　12　5　338　2013/07
  • 　Novel design and synthesis of a radioiodinated glycolipid analog as an acceptor substrate for N-acetylglucosaminyltransferase V　Kenji Arimitsu,Hiroyuki Kimura,Tetsuya Kajimoto,Masahiro Ono,Yoshiro Ohmomo,Masayuki Yamashita,Manabu Node,Hideo Saji　JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS　56　11　562　2013/09
  • 　Preparation of Asymmetric Urea Derivatives that Target Prostate-Specific Membrane Antigen for SPECT Imaging　Naoya Harada,Hiroyuki Kimura,Masahiro Ono,Hideo Saji　JOURNAL OF MEDICINAL CHEMISTRY　56　20　7890　2013/10
  • 　Synthesis and evaluation of (-)- and (+)-[C-11]galanthamine as PET tracers for cerebral acetylcholinesterase imaging　Hiroyuki Kimura,Tomoki Kawai,Yoshio Hamashima,Hidekazu Kawashima,Kenji Miura,Yuta Nakaya,Makoto Hirasawa,Kenji Arimitsu,Tetsuya Kajimoto,Yoshiro Ohmomo,Masahiro Ono,Manabu Node,Hideo Saji　BIOORGANIC & MEDICINAL CHEMISTRY　22　1　285　2014/01
  • 　Novel radioiodinated 1,3,4-oxadiazole derivatives with improved in vivo properties for SPECT imaging of beta-amyloid plaques　Hiroyuki Watanabe,Masahiro Ono,Hiroyuki Kimura,Kenji Matsumura,Masashi Yoshimura,Shimpei Iikuni,Yoko Okamoto,Masafumi Ihara,Ryosuke Takahashi,Hideo Saji　MEDCHEMCOMM　5　1　82　2014
  • 　A mechanistic investigation of anti-elimination in (Z)-1,2-bis(arylseleno)-1-alkenes and their sulfur analogs　Asami Tarao,Yukako Tabuchi,Eri Sugimoto,Miki Ikeda,Hitomi Uchimoto,Kenji Arimitsu,Hiroyuki Kimura,Ikuo Kawasaki,Masatoshi Kawahata,Kentaro Yamaguchi,Kiyoharu Nishide　ORGANIC & BIOMOLECULAR CHEMISTRY　13　21　5964　2015
  • 　A Ga-68 complex based on benzofuran scaffold for the detection of beta-amyloid plaques　Hiroyuki Watanabe,Masahiro Ono,Shimpei Iikuni,Masashi Yoshimura,Kenji Matsumura,Hiroyuki Kimura,Hideo Saji　BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　24　20　4834　2014/10
  • 　Development of a resonant-type microwave reactor and its application to the synthesis of positron emission tomography radiopharmaceuticals　Hiroyuki Kimura,Yusuke Yagi,Noriyuki Ohneda,Hiro Odajima,Masahiro Ono,Hideo Saji　JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS　57　12　680　2014/10
  • 　Application of Electron Tracking Compton Camera (ETCC) in Medical Imaging　Shinya Sonoda,Yoshikatsu Ichimura,Hiroyuki Kimura,Shigeto Kabuki,Atsushi Takada,Tetsuya Mizmoto,Hidetoshi Kubo,Shohei Miyamoto,Shotaro Komura,Taito Takemura,Tatsuya Sawano,Tetsuro Kishimoto,Yoshihiro Matsuoka,Yoshitaka Mizumura,Toru Tanimori　2015 IEEE NUCLEAR SCIENCE SYMPOSIUM AND MEDICAL IMAGING CONFERENCE (NSS/MIC)　2015
  • 　Gallium-68-Labeled Anti-HER2 Single-Chain Fv Fragment: Development and In Vivo Monitoring of HER2 Expression　Masashi Ueda,Hayato Hisada,Takashi Temma,Yoichi Shimizu,Hiroyuki Kimura,Masahiro Ono,Yuji Nakamoto,Kaori Togashi,Hideo Saji　MOLECULAR IMAGING AND BIOLOGY　17　1　102　2015/02
  • 　Development of [18F]Pitavastatin for the evaluation of in vivo function of organic anion transporting peptide　Yusuke Yagi,Hiroyuki Kimura,Mutsumi Mikamo,Kazuya Maeda,Masahiro Ono,Hiroyuki Kusuhara,Yuichi Sugiyama,Hideo Saji　JOURNAL OF NUCLEAR MEDICINE　55　2014/05
  • 　Feasibility of Amylin Imaging in Pancreatic Islets with beta-Amyloid Imaging Probes　Masashi Yoshimura,Masahiro Ono,Hiroyuki Watanabe,Hiroyuki Kimura,Hideo Saji　SCIENTIFIC REPORTS　4　6155　2014/08
  • 　Synthesis and evaluation of F-18-labeled mitiglinide derivatives as positron emission tomography tracers for beta-cell imaging　Hiroyuki Kimura,Hirokazu Matsuda,Hiroyuki Fujimoto,Kenji Arimitsu,Kentaro Toyoda,Eri Mukai,Hiroshi Nakamura,Yu Ogawa,Mikako Takagi,Masahiro Ono,Nobuya Inagaki,Hideo Saji　BIOORGANIC & MEDICINAL CHEMISTRY　22　13　3270　2014/07
  • 　Evaluation of intratumoral microenvironment with 18F-misonidazole PET and dynamic contrast enhanced CT in tumor-bearing mice models　Sho Koyasu,Yuji Nakamoto,Hiroshi Harada,Hiroyuki Kimura,Kohei Sano,Koji Koizumi,Yoshihisa Tsuji,Tomomi Nobashi,Kensuke Kurihara,Kaori Togashi　JOURNAL OF NUCLEAR MEDICINE　55　2014/05
  • 　Development of resonant-type microwave reactor and its application to PET radiochemistry　Hiroyuki Kimura,Yusuke Yagi,Noriyuki Ohneda,Hiromichi Odajima,Hideo Saji　JOURNAL OF NUCLEAR MEDICINE　55　2014/05
  • 　Radiosynthesis of [18F]FPYBF-2, a novel PET imaging probe for beta-amyloid plaques in brain　Shinya Kagawa,Ryuichi Nishii,Tatsuya Higashi,Hiroshi Yamauchi,Keiichi Kawai,Hiroyuki Watanabe,Hiroyuki Kimura,Masahiro Ono,Hideo Saji　JOURNAL OF NUCLEAR MEDICINE　55　2014/05
  • 　[112th Scientific Meeting of the Japanese Society of Internal Medicine: Presidential Lecture: Panel discussion: Preemptive Medicine for Diabetes Mellitus].　Inagaki N,Fujita N,Kimura H,Hamamatsu K,Sano K,Hirai M,Murakami A,Saji H,Fujimoto H　Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine　104　9　1803　2015/09
  • 　Development of Tc-99m-labeled asymmetric urea derivatives that target prostate-specific membrane antigen for single-photon emission computed tomography imaging　Hiroyuki Kimura,Sotaro Sampei,Daiko Matsuoka,Naoya Harada,Hiroyuki Watanabe,Kenji Arimitsu,Masahiro Ono,Hideo Saji　BIOORGANIC & MEDICINAL CHEMISTRY　24　10　2251　2016/05
  • 　Development of Gd3N@C80 encapsulated redox nanoparticles for high-performance magnetic resonance imaging　Zenyu, Gao,Yusuke, Nakanishi,Shoko, Noda,Haruka, Omachi,Hisanori, Shinohara,Kimura, Hiroyuki,長崎, 幸夫　Journal of Biomaterials Science: Polymer Edition　28　10-12:::SI　1036　2017
  • 　Evaluation of Tumor-associated Stroma and Its Relationship with Tumor Hypoxia Using Dynamic Contrast-enhanced CT and F-18 Misonidazole PET in Murine Tumor Models　Sho Koyasu,Yoshihisa Tsuji,Hiroshi Harada,Yuji Nakamoto,Tomomi Nobashi,Hiroyuki Kimura,Kohei Sano,Koji Koizumi,Masatsugu Hamaji,Kaori Togashi　RADIOLOGY　278　3　734　2016/03
  • 　Structure-Activity Relationship Study of Heterocyclic Phenylethenyl and Pyridinylethenyl Derivatives as Tau-Imaging Agents That Selectively Detect Neurofibrillary Tangles in Alzheimer's Disease Brains.　Kenji Matsumura,Masahiro Ono,Ayane Kitada,Hiroyuki Watanabe,Masashi Yoshimura,Shimpei Iikuni,Hiroyuki Kimura,Yoko Okamoto,Masafumi Ihara,Hideo Saji　Journal of medicinal chemistry　58　18　7241　2015/09/24
  • 　Imaging of Cerebral Amyloid Angiopathy with Bivalent Tc-99m-Hydroxamamide Complexes　Shimpei Iikuni,Masahiro Ono,Hiroyuki Watanabe,Kenji Matsumura,Masashi Yoshimura,Hiroyuki Kimura,Hatsue Ishibashi-Ueda,Yoko Okamoto,Masafumi Ihara,Hideo Saji　SCIENTIFIC REPORTS　6　25990　2016/05
  • 　Development of a local anesthetic lidocaine-loaded redox-active injectable gel for postoperative pain management　Yukio Nagasaki,Yutaro Mizukoshi,Zhenyu Gao,Chitho P. Feliciano,Kyungho Chang,Hiroshi Sekiyama,Hiroyuki Kimura　ACTA BIOMATERIALIA　57　127　2017/07
  • 　Long-term bioavailability of redox nanoparticles effectively reduces organ dysfunctions and death in whole-body irradiated mice　Chitho P. Feliciano,Koji Tsuboi,Kenshi Suzuki,Hiroyuki Kimura,Yukio Nagasaki　Biomaterials　129　68　2017/06/01
  • 　Aggregation is a critical cause of poor transfer into the brain tissue of intravenously administered cationic PAMAM dendrimer nanoparticles　Yoshika Kurokawa,Hideko Sone,Tin-Tin Win-Shwe,Yang Zeng,Hiroyuki Kimura,Yosuke Koyama,Yusuke Yagi,Yasuto Matsui,Masashi Yamazaki,Seishiro Hirano　International Journal of Nanomedicine　12　3967　2017/05/24
  • 　Radiosynthesis of [C-11] PiB for the loop labeling method using a cassette-type multipurpose automatic synthesizer module　Shinya Kagawa,Ryuichi Nishii,Tatsuya Higashi,Hiroshi Yamauchi,Keiichi Kawai,Hiroyuki Watanabe,Hiroyuki Kimura,Masahiro Ono,Hideo Saji　JOURNAL OF NUCLEAR MEDICINE　58　2017/05
  • 　F-18-Labeled Pyrido[3,4-d]pyrimidine as an Effective Probe for Imaging of L858R Mutant Epidermal Growth Factor Receptor　Hiroyuki Kimura,Haruka Okuda,Masumi Ishiguro,Kenji Arimitsu,Akira Makino,Ryuichi Nishii,Anna Miyazaki,Yusuke Yagi,Hiroyuki Watanabe,Ikuo Kawasaki,Masahiro Ono,Hideo Saji　ACS MEDICINAL CHEMISTRY LETTERS　8　4　418　2017/04
  • 　Development of In-111-labeled exendin(9-39) derivatives for single-photon emission computed tomography imaging of insulinoma　Hiroyuki Kimura,Hirokazu Matsuda,Yu Ogawa,Hiroyuki Fujimoto,Kentaro Toyoda,Naotaka Fujita,Kenji Arimitsu,Keita Hamamatsu,Yusuke Yagi,Masahiro Ono,Nobuya Inagaki,Hideo Saji　BIOORGANIC & MEDICINAL CHEMISTRY　25　4　1406　2017/02
  • 　Aggregation is a critical cause of poor transfer into the brain tissue of intravenously administered cationic PAMAM dendrimer nanoparticles　Yoshika Kurokawa,Hideko Sone,Tin-Tin Win-Shwe,Yang Zeng,Hiroyuki Kimura,Yosuke Koyama,Yusuke Yagi,Yasuto Matsui,Masashi Yamazaki,Seishiro Hirano　INTERNATIONAL JOURNAL OF NANOMEDICINE　12　3967　2017
  • 　Synthesis and Biologic Evaluation of Novel F-18-Labeled Probes Targeting Prostate-Specific Membrane Antigen for PET of Prostate Cancer　Naoya Harada,Hiroyuki Kimura,Satoru Onoe,Hiroyuki Watanabe,Daiko Matsuoka,Kenji Arimitsu,Masahiro Ono,Hideo Saji　JOURNAL OF NUCLEAR MEDICINE　57　12　1978　2016/12
  • 　Radiosynthesis of novel pitavastatin derivative ([F-18]PTV-F1) as a tracer for hepatic OATP using a one-pot synthetic procedure　Hiroyuki Kimura,Yusuke Yagi,Kenji Arimitsu,Kazuya Maeda,Kazuaki Ikejiri,Jun-ichi Takano,Hiroyuki Kusuhara,Shinya Kagawa,Masahiro Ono,Yuichi Sugiyama,Hideo Saji　JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS　59　13　565　2016/11
  • 　Non-invasive pancreatic beta-cell imaging using radiolabeled exendin probe　Nobuya Inagaki,Hiroyuki Fujimoto,Hiroyuki Kimura,Naotaka Fujita,Keita Hamamatsu,Hideo Saji　DIABETES RESEARCH AND CLINICAL PRACTICE　120　S18　2016/10
  • 　Noninvasive Quantification of Beta-Cell Mass with Radioisotope-labeled Exendin Probe　Fujita Naotaka,Fujimoto Hiroyuki,Hamamatsu Keita,Kimura Hiroyuki,Sano Kohei,Toyoda Kentaro,Saji Hideo,Inagaki Nobuya　DIABETES　65　A531　2016/06
  • 　Development of Tc-99m-Labeled Pyridyl Benzofuran Derivatives To Detect Pancreatic Amylin in Islet Amyloid Model Mice　Masashi Yoshimura,Masahiro Ono,Hiroyuki Watanabe,Hiroyuki Kimura,Hideo Saji　BIOCONJUGATE CHEMISTRY　27　6　1532　2016/06
  • 　Development of a PET Imaging Probe for Discrimination of Secondary Mutation in the Epidermal Growth Factor Receptor　Kimura Hiroyuki,Okuda Haruka,Arimitsu Kenji,Makino Akira,Nishii Ryuichi,Miyazaki Anna,Watanabe Hiroyuki,Ono Masahiro,Saji Hideo　JOURNAL OF NUCLEAR MEDICINE　57　2016/05/01
  • 　Development of a PET probe detecting tumors, which are responsive to gefitinib treatment　Makino Akira,Miyazaki Anna,Kimura Hiroyuki,Hirata Masahiko,Ohmomo Yoshiro,Nishii Ryuichi,Okazawa Hidehiko,Kiyono Yasushi,Ono Masahiro,Saji Hideo　JOURNAL OF NUCLEAR MEDICINE　57　2016/05/01
  • 　Application of Microreactor to the Preparation of C-11-Labeled Compounds via O-[C-11]Methylation with [C-11]CH3I: Rapid Synthesis of [C-11]Raclopride　Hidekazu Kawashima,Hiroyuki Kimura,Yuta Nakaya,Kenji Tomatsu,Kenji Arimitsu,Hiroaki Nakanishi,Eiichi Ozeki,Yuji Kuge,Hideo Saji　CHEMICAL & PHARMACEUTICAL BULLETIN　63　9　737　2015/09
  • 　F-18-Containing Positron Emission Tomography Probe Conjugation Methodology for Biologics as Specific Binders for Tumors　Kenji Arimitsu,Hiroyuki Kimura,Yoshinari Arai,Kazuto Mochizuki,Masumi Taki　CURRENT TOPICS IN MEDICINAL CHEMISTRY　16　24　2703　2016
  • 　Synthesis and preliminary characterization of radioiodinated benzofuran-3-yl-(indol-3-yl)maleimide derivatives as potential SPECT imaging probes for the detection of glycogen synthase kinase-3 (GSK-3) in the brain　Masahiro Ono,Ayane Kitada,Hiroyuki Watanabe,Anna Miyazaki,Hiroyuki Kimura,Hideo Saji　JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS　59　8　317　2016/06
  • 　A Novel CYP11B2-Specific Imaging Agent for Detection of Unilateral Subtypes of Primary Aldosteronism　Tsutomu Abe,Mitsuhide Naruse,William F. Young,Nobuya Kobashi,Yoshihiro Doi,Akihiro Izawa,Kei Akama,Yuki Okumura,Miho Ikenaga,Hiroyuki Kimura,Hideo Saji,Kuniaki Mukai,Hiroki Matsumoto　JOURNAL OF CLINICAL ENDOCRINOLOGY & METABOLISM　101　3　1008　2016/03
  • 　Continuous-Flow Synthesis of N-Succinimidyl 4-[F-18]fluorobenzoate Using a Single Microfluidic Chip　Hiroyuki Kimura,Kenji Tomatsu,Hidekazu Saiki,Kenji Arimitsu,Masahiro Ono,Hidekazu Kawashima,Ren Iwata,Hiroaki Nakanishi,Eiichi Ozeki,Yuji Kuge,Hideo Saji　PLOS ONE　11　7　e0159303　2016/07
  • 　Radiosynthesis of [F-18]PTV-F1, pitavastatin (HMG-CoA reductase inhibitor) derivative for Organic Anion Transporter Imaging of Liver　Shinya Kagawa,Ryuichi Nishii,Tatsuya Higashi,Hiroshi Yamauchi,Keiichi Kawai,Hiroyuki Kimura,Masahiro Ono,Yuichi Sugiyama,Hideo Saji　JOURNAL OF NUCLEAR MEDICINE　56　3　2015/05
  • 　Development of Tc-99m labeled pyridyl benzofuran derivatives for the imaging of islet amyloids in the pancreas　Masashi Yoshimura,Masahiro Ono,Hiroyuki Watanabe,Hiroyuki Kimura,Hideo Saji　JOURNAL OF NUCLEAR MEDICINE　56　3　2015/05
  • 　[ F-18]PTV-F1 PET for OATP Transporter Imaging of the Liver. -Preclinical and Phase I Clinical Study-　Ryuichi Nishii,Shinya Kagawa,Tatsuya Higashi,Hiroshi Yamauchi,Hiroyuki Kimura,Keiichi Kawai,Shigeki Nagamachi,Masahiro Ono,Yuichi Sugiyama,Hideo Saji　JOURNAL OF NUCLEAR MEDICINE　56　3　2015/05
  • 　Novel tau-SPECT imaging agents based on pyrido[1,2-a]benzoimidazole scaffold　Masahiro Ono,Kenji Matsumura,Hiroyuki Watanabe,Hiroyuki Kimura,Hideo Saji　JOURNAL OF NUCLEAR MEDICINE　56　3　2015/05
  • 　Development of a Continuous Flow Microwave Reactor and Its Application to the Radiochemistry　Hiroyuki Kimura,Noriyuki Ohneda,Hiro Odajima,Masahiro Ono,Hideo Saji　JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS　58　S234　2015/05
  • 　Mechanistic aspects of asymmetric intramolecular Heck reaction involving dynamic kinetic resolution: flexible conformation of the cyclohexenylidene-benzene system　Shinzo Hosoi,Minoru Ozeki,Masashi Nakano,Kenji Arimitsu,Tetsuya Kajimoto,Naoto Kojima,Hiroki Iwasaki,Takuya Miura,Hiroyuki Kimura,Manabu Node,Masayuki Yamashita　TETRAHEDRON　71　15　2317　2015/04
  • 　Stability of Myocardial F-18-flurpiridazDistribution after Transient Coronary Occlusion in Pigs　Werner Rudolf,Koshino Kazuhiro,Arimitsu Kenji,Lapa Constantin,Fukujima Kenji,Rowe Steven,Nose Naoko,Kimura Hiroyuki,Higuchi Takahiro　JOURNAL OF NUCLEAR MEDICINE　60　2019/05/01
  • 　Structure–activity relationships of succinimidyl-Cys-C(O)-Glu derivatives with different near-infrared fluorophores as optical imaging probes for prostate-specific membrane antigen　Daiko Matsuoka,Hiroyuki Watanabe,Yoichi Shimizu,Hiroyuki Kimura,Yusuke Yagi,Ryoko Kawai,Masahiro Ono,Hideo Saji　Bioorganic and Medicinal Chemistry　26　9　2291　2018/05/15
  • 　l-Serine-modified polyamidoamine dendrimer as a highly potent renal targeting drug carrier.　Matsuura S,Katsumi H,Suzuki H,Hirai N,Hayashi H,Koshino K,Higuchi T,Yagi Y,Kimura H,Sakane T,Yamamoto A　Proceedings of the National Academy of Sciences of the United States of America　115　41　10511　2018/10
  • 　Establishment of a method for in-vivo SPECT/CT imaging analysis of 111In-labeled exendin-4 pancreatic uptake in mice without the need for nephrectomy or a secondary probe.　Hamamatsu K,Fujimoto H,Fujita N,Murakami T,Kimura H,Saji H,Inagaki N　Nuclear medicine and biology　64-65　22　2018/09
  • 　Development and characterization of a 68Ga-labeled A20FMDV2 peptide probe for the PET imaging of αvβ6 integrin-positive pancreatic ductal adenocarcinoma　Takashi Ui,Masashi Ueda,Yusuke Higaki,Shinichiro Kamino,Kohei Sano,Hiroyuki Kimura,Hideo Saji,Shuichi Enomoto　Bioorganic & Medicinal Chemistry　28　1　115189　2020/01
  • 　Development of 99mTc radiolabeled A85380 derivatives targeting cerebral nicotinic acetylcholine receptor: Novel radiopharmaceutical ligand 99mTc-A-YN-IDA-C4.　Daisuke Mori,Hiroyuki Kimura,Hidekazu Kawashima,Yusuke Yagi,Kenji Arimitsu,Masahiro Ono,Hideo Saji　Bioorganic & medicinal chemistry　27　18　4200　2019/09/15
  • 　Stability of Distribution of F18 Flurpiridaz After Transient Coronary Occlusion in Pigs.　Rudolf A Werner,Kazuhiro Koshino,Kenji Arimitsu,Constantin Lapa,Mehrbod S Javadi,Steven P Rowe,Naoko Nose,Hiroyuki Kimura,Kenji Fukushima,Takahiro Higuchi　JACC. Cardiovascular imaging　12　11 Pt 1　2269　2019/11
  • 　18F-Labeled, PSMA-Targeted Radiotracers: Leveraging the Advantages of Radiofluorination for Prostate Cancer Molecular Imaging.　Werner RA,Derlin T,Lapa C,Sheikbahaei S,Higuchi T,Giesel FL,Behr S,Drzezga A,Kimura H,Buck AK,Bengel FM,Pomper MG,Gorin MA,Rowe SP　Theranostics　2020/01　
  • 　Synthesis and in vivo evaluation of fluorine-18 labeled streptozotocin derivative as a pancreatic beta-cell imaging probe　Arimitsu Kenji,Kimura Hiroyuki,Yagi Yusuke,Koshino Kazuhiro,Hirano Mitsuru,Higuchi Takahiro,Yasui Hiroyuki　ABSTRACTS OF PAPERS OF THE AMERICAN CHEMICAL SOCIETY　256　2018/08/19
  • 　Initial evaluation of PET / CT with 18 F‐ FSU ‐880 targeting prostate‐specific membrane antigen in prostate cancer patients　Tsuneo Saga,Yuji Nakamoto,Takayoshi Ishimori,Takahiro Inoue,Yoichi Shimizu,Hiroyuki Kimura,Shusuke Akamatsu,Takayuki Goto,Hiroyuki Watanabe,Kosuke Kitaguchi,Masao Watanabe,Masahiro Ono,Hideo Saji,Osamu Ogawa,Kaori Togashi　Cancer Science　110　2　742　2019/02　
  • 　Evaluation of transporter-mediated hepatobiliary transport of newly developed 18F-labeled pitavastatin derivative, PTV-F1, in rats by PET imaging.　Kimura H,Yagi Y,Mikamo M,Kazuya M,Kagawa S,Arimitsu K,Higashi T,Nishii R,Ono M,Nakamoto Y,Togashi K,Kusuhara H,Saji H　Drug metabolism and pharmacokinetics　34　5　317　2019/06
  • 　Initial evaluation of PET/CT with F-18-FSU-880 targeting prostate-specific membrane antigen in prostate cancer patients　Saga Tsuneo,Nakamoto Yuji,Ishimori Takayoshi,Inoue Takahiro,Shimizu Yoichi,Kimura Hiroyuki,Akamatsu Shusuke,Goto Takayuki,Watanabe Hiroyuki,Kitaguchi Kosuke,Watanabe Masao,Ono Masahiro,Saji Hideo,Ogawa Osamu,Togashi Kaori　Cancer Sci　110　2　742　2019
  • 　Synthesis and biological evaluation of Tc-99m-cyclopentadienyltricarbonyl-technetium-labeled A-85380: An imaging probe for single-photon emission computed tomography investigation of nicotinic acetylcholine receptors in the brain.　Kimura H,Ueda M,Kawashima H,Arimitsu K,Yagi Y,Saji H　Bioorganic & medicinal chemistry　27　11　2245　2019/06/01
  • 　Electron-tracking Compton camera imaging of technetium-95m　Yuichi Hatsukawa,Takehito Hayakawa,Kazuaki Tsukada,Kazuyuki Hashimoto,Tetsuya Sato,Masato Asai,Atsushi Toyoshima,Toru Tanimori,Shinya Sonoda,Shigeto Kabuki,Hiroyuki Kimura,Atsushi Takada,Tetsuya Mizumoto,Seiya Takaki　PLOS ONE　13　12　e0208909　2018/12/10　
  • 　Initial Evaluation of AF78: a Rationally Designed Fluorine-18-Labelled PET Radiotracer Targeting Norepinephrine Transporter.　Chen X,Fritz A,Werner RA,Nose N,Yagi Y,Kimura H,Rowe SP,Koshino K,Decker M,Higuchi T　Molecular imaging and biology : MIB : the official publication of the Academy of Molecular Imaging　22　3　602　2019/07
  • 　18 F-Labeled Derivatives of Irbesartan for Angiotensin II Receptor PET Imaging.　Hoffmann M,Chen X,Hirano M,Arimitsu K,Kimura H,Higuchi T,Decker M　ChemMedChem　13　23　2546　2018/12/06
  • 　Enhanced intestinal 2-deoxy-2-[18F]fluoro-D-glucose uptake under metformin is not fully suppressed by loperamide.　Tomomi Nobashi,Tsuneo Saga,Yuji Nakamoto,Yoichi Shimizu,Sho Koyasu,Takayoshi Ishimori,Masao Watanabe,Hiroyuki Kimura,Kaori Togashi　Endocrine regulations　52　4　185　2018/10/01
  • 　Synthesis and evaluation of a [18F]formyl-Met-Leu-Phe derivative: A positron emission tomography imaging probe for bacterial infections.　Kimura H,Yamauchi S,Kawashima H,Arimitsu K,Yagi Y,Nakamoto Y,Togashi K,Ono M,Saji H　Bioorganic & medicinal chemistry letters　28　17　2949　2018/09/15
  • 　S-nitrosylated l-serine-modified dendrimer as a kidney-targeting nitric oxide donor for prevention of renal ischaemia/reperfusion injury.　Hidemasa Katsumi,Rie Takashima,Hiroe Suzuki,Natsuko Hirai,Satoru Matsuura,Hiroyuki Kimura,Masaki Morishita,Akira Yamamoto　Free radical research　54　11-12　1　2019/12/03
  • 　Evaluation of 18F-labeled exendin(9-39) derivatives targeting glucagon-like peptide-1 receptor for pancreatic β-cell imaging　Hiroyuki Kimura,Yu Ogawa,Hiroyuki Fujimoto,Eri Mukai,Hidekazu Kawashima,Kenji Arimitsu,Kentaro Toyoda,Naotaka Fujita,Yusuke Yagi,Keita Hamamatsu,Takaaki Murakami,Atsushi Murakami,Masahiro Ono,Yuji Nakamoto,Kaori Togashi,Nobuya Inagaki,Hideo Saji　Bioorganic and Medicinal Chemistry　26　2　463　2018/01/15
  • 　Evaluation of [18F]pitavastatin as a positron emission tomography tracer for in vivo organic transporter polypeptide function　Yusuke Yagi,Hiroyuki Kimura,Haruka Okuda,Masahiro Ono,Yuji Nakamoto,Kaori Togashi,Hideo Saji　Nuclear Medicine and Biology　74-75　25　2019/07/01　
  • 　Efficient gallium-68 radiolabeling reaction of DOTA derivatives using a resonant-type microwave reactor　Yusuke Yagi,Yoichi Shimizu,Kenji Arimitsu,Yuji Nakamoto,Takahiro Higuchi,Kaori Togashi,Hiroyuki Kimura　JOURNAL OF LABELLED COMPOUNDS & RADIOPHARMACEUTICALS　62　3　132　2019/03
  • 　Synthesis and biological evaluation of an In-111-labeled exendin-4 derivative as a single-photon emission computed tomography probe for imaging pancreatic beta-cells　Hiroyuki Kimura,Naotaka Fujita,Kaori Kanbe,Hirokazu Matsuda,Hiroyuki Watanabe,Kenji Arimitsu,Hiroyuki Fujimoto,Keita Hamamatsu,Yusuke Yagi,Masahiro Ono,Nobuya Inagaki,Hideo Saji　BIOORGANIC & MEDICINAL CHEMISTRY　25　20　5772　2017/10
  • 　18F-FPYBF-2, a new F-18-labelled amyloid imaging PET tracer: first experience in 61 volunteers and 55 patients with dementia　Tatsuya Higashi,Ryuichi Nishii,Shinya Kagawa,Yoshihiko Kishibe,Masaaki Takahashi,Tomoko Okina,Norio Suzuki,Hiroshi Hasegawa,Yasuhiro Nagahama,Koichi Ishizu,Naoya Oishi,Hiroyuki Kimura,Hiroyuki Watanabe,Masahiro Ono,Hideo Saji,Hiroshi Yamauchi　Annals of Nuclear Medicine　32　3　206　2018/04/01
  • 　18F-FPYBF-2, a new F-18 labelled amyloid imaging PET tracer: biodistribution and radiation dosimetry assessment of first-in-man 18F-FPYBF-2 PET imaging　Ryuichi Nishii,Tatsuya Higashi,Shinya Kagawa,Chio Okuyama,Yoshihiko Kishibe,Masaaki Takahashi,Tomoko Okina,Norio Suzuki,Hiroshi Hasegawa,Yasuhiro Nagahama,Koichi Ishizu,Naoya Oishi,Hiroyuki Kimura,Hiroyuki Watanabe,Masahiro Ono,Hideo Saji,Hiroshi Yamauchi　Annals of Nuclear Medicine　32　4　256　2018/05/01
  • 　Comparison of [F-18]PTV-F1 and [F-18]pitavastatin as a PET probe for evaluation of hepatic organic anion transporting polypeptides function　Yusuke Yagi,Hiroyuki Kimura,Kenji Arimitsu,Hiroyuki Yasui,Masahiro Ono,Hideo Saji　JOURNAL OF NUCLEAR MEDICINE　59　2018/05
  • 　Noninvasive longitudinal quantification of β-cell mass with [111In]-labeled exendin-4.　Fujita N,Fujimoto H,Hamamatsu K,Murakami T,Kimura H,Toyoda K,Saji H,Inagaki N　FASEB journal : official publication of the Federation of American Societies for Experimental Biology　33　11　fj201900555RR　2019/08
  • 　PET probe detecting non-small cell lung cancer susceptible to epidermal growth factor receptor tyrosine kinase inhibitor therapy　Akira Makino,Anna Miyazaki,Ayaka Tomoike,Hiroyuki Kimura,Kenji Arimitsu,Masahiko Hirata,Yoshiro Ohmomo,Ryuichi Nishii,Hidehiko Okazawa,Yasushi Kiyono,Masahiro Ono,Hideo Saji　Bioorganic and Medicinal Chemistry　26　8　1609　2018/05/01
  • 　Absolute Configuration of Eight Cephalimysins Isolated from the Marine-Derived Aspergillus fumigatus.　Takeshi Yamada,Hiroyuki Kimura,Kenji Arimitsu,Tetsuya Kajimoto,Takashi Kikuchi,Reiko Tanaka　CHEMISTRYSELECT　2　33　10936　2017/11
  • 　Obesity-promoting and anti-thermogenic effects of neutrophil gelatinase-associated lipocalin in mice　Akira Ishii,Goro Katsuura,Hirotaka Imamaki,Hiroyuki Kimura,Keita P. Mori,Takashige Kuwabara,Masato Kasahara,Hideki Yokoi,Kousaku Ohinata,Tomoko Kawanishi,Junichi Tsuchida,Yuji Nakamoto,Kazuwa Nakao,Motoko Yanagita,Masashi Mukoyama,Kiyoshi Mori　SCIENTIFIC REPORTS　7　2017/11
  • 　Synthesis and evaluation of a novel near-infrared fluorescent probe based on succinimidyl-Cys-C(O)-Glu that targets prostate-specific membrane antigen for optical imaging　Daiko Matsuoka,Hiroyuki Watanabe,Yoichi Shimizu,Hiroyuki Kimura,Masahiro Ono,Hideo Saji　BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　27　21　4876　2017/11
  • 　Efficacy of Panitumumab and Cetuximab in Patients with Colorectal Cancer Previously Treated with Bevacizumab; a Combined Analysis of Individual Patient Data from ASPECCT and WJOG6510G　Hiroya Taniguchi,Takeharu Yamanaka,Daisuke Sakai,Kei Muro,Kentaro Yamazaki,Susumu Nakata,Hiroyuki Kimura,Paul Ruff,Tae Won Kim,Marc Peeters,Timothy Price　Cancers　12　7　1715　2020/06/28　
  • 　Development of novel radioiodinated exendin-4 derivatives targeting GLP-1 receptor for detection of β-cell mass　Yu Ogawa,Hiroyuki Kimura,Hiroyuki Fujimoto,Hidekazu Kawashima,Kentaro Toyoda,Eri Mukai,Yusuke Yagi,Masahiro Ono,Nobuya Inagaki,Hideo Saji　Bioorganic & Medicinal Chemistry　52　116496　2021/12
  • 　Effect of Water on Direct Radioiodination of Small Molecules/Peptides Using Copper-Mediated Iododeboronation in Water–Alcohol Solvent　Yuto Kondo,Hiroyuki Kimura,Minon Sasaki,Sumina Koike,Yusuke Yagi,Yasunao Hattori,Hidekazu Kawashima,Hiroyuki Yasui　ACS Omega　8　27　24418　2023/06/27　
  • 　Aicardi–Goutières syndrome-like encephalitis in mutant mice with constitutively active MDA5　Hideo Onizawa,Hiroki Kato,Hiroyuki Kimura,Tomoo Kudo,Nobumasa Soda,Shota Shimizu,Masahide Funabiki,Yusuke Yagi,Yuji Nakamoto,Josef Priller,Ryuta Nishikomori,Toshio Heike,Nan Yan,Tohru Tsujimura,Tsuneyo Mimori,Takashi Fujita　International Immunology　33　4　225　2020/11/09　
  • 　Automatic radioisotope manipulation for small amount of nuclear medicine using an EWOD device with a dimple structure　Katsuo Mogi,Hiroyuki Kimura,Yuto Kondo,Tomoya Inoue,Shungo Adachi,Tohru Natsume　Royal Society Open Science　8　5　201809　2021/05　
  • 　Strong binding affinity of D-allulose and allulosides to boronic acids and the structural characterization of their sugar-boronate complexes　Kenji Arimitsu,Hiroki Iwasaki,Hiroyuki Kimura,Hiroyuki Yasui　Chemistry Letters　50　8　1470　2021/05/20　
  • 　First-in-Human Evaluation of Positron Emission Tomography/Computed Tomography With [18F]FB(ePEG12)12-Exendin-4: A Phase 1 Clinical Study Targeting GLP-1 Receptor Expression Cells in Pancreas　Hiroyuki Fujimoto,Naotaka Fujita,Keita Hamamatsu,Takaaki Murakami,Yuji Nakamoto,Tsuneo Saga,Takayoshi Ishimori,Yoichi Shimizu,Hiroyuki Watanabe,Kohei Sano,Norio Harada,Hiroshi Nakamura,Kentaro Toyoda,Hiroyuki Kimura,Shunsaku Nakagawa,Mitsuharu Hirai,Atsushi Murakami,Masahiro Ono,Kaori Togashi,Hideo Saji,Nobuya Inagaki　Frontiers in Endocrinology　12　717101　2021/08/19　
  • 　Nicotinic Acetylcholine Receptors and Microglia as Therapeutic and Imaging Targets in Alzheimer’s Disease　Kazuyuki Takata,Hiroyuki Kimura,Daijiro Yanagisawa,Koki Harada,Kaneyasu Nishimura,Yoshihisa Kitamura,Shun Shimohama,Ikuo Tooyama　Molecules (Basel, Switzerland)　27　9　1　2022/04
  • 　Novel synthesis of an [18F]aryl boronic acid ester as a reagent for 18F-labeling via Suzuki coupling　Yusuke Yagi,Hiroyuki Kimura,Yuto Kondo,Takahiro Higuchi　Tetrahedron Letters　154010　2022/07
  • 　Microfluidic technology for making string-like cell tissues　Katsuo Mogi,Hiroyuki Kimura,Naoki Takada　2022 IEEE CPMT Symposium Japan (ICSJ)　2022/11/09　
  • 　Copper-mediated radioiodination and radiobromination via aryl boronic precursor and its application to 125I/77Br–labeled prostate-specific membrane antigen imaging probes　Yuto Kondo,Hiroyuki Kimura,Ichiro Sasaki,Shigeki Watanabe,Yasuhiro Ohshima,Yusuke Yagi,Yasunao Hattori,Manami Koda,Hidekazu Kawashima,Hiroyuki Yasui,Noriko S. Ishioka　Bioorganic & Medicinal Chemistry　69　116915　2022/09
  • 　Novel [111In]In-BnDTPA-EphA2-230-1 Antibody for Single-Photon Emission Computed Tomography Imaging Tracer Targeting of EphA2　Takenori Furukawa,Hiroyuki Kimura,Minon Sasaki,Takumu Yamada,Takumi Iwasawa,Yusuke Yagi,Kazunori Kato,Hiroyuki Yasui　ACS Omega　8　7　7030　2023/02/09　
  • 　Dendrimer-based micelles with highly potent targeting to sites of active bone turnover for the treatment of bone metastasis　Shugo Yamashita,Hidemasa Katsumi,Erika Shimizu,Yuto Nakao,Ayane Yoshioka,Minako Fukui,Hiroyuki Kimura,Toshiyasu Sakane,Akira Yamamoto　European Journal of Pharmaceutics and Biopharmaceutics　157　157　85　2020/10
  • 　Plantainoside B in Bacopa monniera binds to Aβ aggregates attenuating neuronal damage and memory deficits induced by Aβ.　Aina Fukuda,Souichi Nakashima,Yoshimi Oda,Kaneyasu Nishimura,Hidekazu Kawashima,Hiroyuki Kimura,Takashi Ohgita,Eri Kawashita,Keiichi Ishihara,Aoi Hanaki,Mizuki Okazaki,Erika Matsuda,Yui Tanaka,Seikou Nakamura,Takahiro Matsumoto,Satoshi Akiba,Hiroyuki Saito,Hisashi Matsuda,Kazuyuki Takata　Biol. Pharm. Bull　46　2　320　2022/12
  • 　Synthesis of 18F-labeled streptozotocin derivatives and an in-vivo kinetics study using positron emission tomography　Kenji Arimitsu,Yusuke Yagi,Kazuhiro Koshino,Yukina Nishito,Takahiro Higuchi,Hiroyuki Yasui,Hiroyuki Kimura　Bioorganic & Medicinal Chemistry Letters　30　17　127400　2020/09
  • 　A Putative Single-Photon Emission CT Imaging Tracer for Erythropoietin-Producing Hepatocellular A2 Receptor　Takenori Furukawa,Hiroyuki Kimura,Hanae Torimoto,Yusuke Yagi,Hidekazu Kawashima,Kenji Arimitsu,Hiroyuki Yasui　ACS Medicinal Chemistry Letters　12　8　1238　2021/07/14　
  • 　Copper‐mediated radioiodination reaction through aryl boronic acid or ester precursor and its application to direct radiolabeling of a cyclic peptide　Yuto Kondo,Hiroyuki Kimura,Chiaki Fukumoto,Yusuke Yagi,Yasunao Hattori,Hidekazu Kawashima,Hiroyuki Yasui　Journal of Labelled Compounds and Radiopharmaceuticals　64　8　336　2021/06/30　
  • 　Distinctive detection of insulinoma using [18F]FB(ePEG12)12-exendin-4 PET/CT　Takaaki Murakami,Hiroyuki Fujimoto,Keita Hamamatsu,Yuki Yamauchi,Yuzo Kodama,Naotaka Fujita,Junji Fujikura,Yoichi Shimizu,Yuji Nakamoto,Hiroyuki Kimura,Hideo Saji,Nobuya Inagaki　Scientific Reports　11　1　15014　2021/12　
  • 　L-Serine-Modified Poly-L-Lysine as a Biodegradable Kidney-Targeted Drug Carrier for the Efficient Radionuclide Therapy of Renal Cell Carcinoma　Hidemasa Katsumi,Sho Kitada,Shintaro Yasuoka,Rie Takashima,Tomoki Imanishi,Rina Tanaka,Satoru Matsuura,Hiroyuki Kimura,Hidekazu Kawashima,Masaki Morishita,Akira Yamamoto　Pharmaceutics　14　9　1946　2022/09/14　
  • 　Mirror-Image Single-Domain Antibody for a Novel Nonimmunogenic Drug Scaffold.　Keisuke Aoki,Asako Manabe,Hiroyuki Kimura,Yohei Katoh,Shinsuke Inuki,Hiroaki Ohno,Motohiro Nonaka,Shinya Oishi　Bioconjugate chemistry　34　11　2055　2023/11/15
  • 　Synthesis and Biological Evaluation of a Novel Sugar-Conjugated Platinum(II) Complex Having a Tumor-Targeting Effect　Marina Omokawa,Hiroyuki Kimura,Kenji Arimitsu,Yusuke Yagi,Yasunao Hattori,Hidekazu Kawashima,Yuki Naito,Hiroyuki Yasui　ACS Omega　9　1　879　2023/12/27　
  • 　Production and synthesis of a novel 191Pt-labeled platinum complex and evaluation of its biodistribution in healthy mice　Marina Omokawa,Hiroyuki Kimura,Yuichi Hatsukawa,Hidekazu Kawashima,Kazuaki Tsukada,Yusuke Yagi,Yuki Naito,Hiroyuki Yasui　Bioorganic & Medicinal Chemistry　97　117557　2024/01
  • 　One-pot two-step radioiodination based on copper-mediated iododeboronation and azide–alkyne cycloaddition reaction　Yuto Kondo,Hiroyuki Kimura,Ryota Chisaka,Yasunao Hattori,Hidekazu Kawashima,Hiroyuki Yasui　Chemical Communications　2024/01
  • 　Copper-mediated astatination of 211At-labelled prostate-specific membrane antigen probes in the presence of basic salts　Shigeki Watanabe,Yuto Kondo,Ichiro Sasaki,Yasuhiro Ohshima,Hiroyuki Kimura,Noriko S. Ishioka　Tetrahedron　133920　2024/03
  • 　Host-to-graft propagation of inoculated α-synuclein into transplanted human induced pluripotent stem cell-derived midbrain dopaminergic neurons　Serina Gima,Kazuya Oe,Kaneyasu Nishimura,Takashi Ohgita,Haruka Ito,Hiroyuki Kimura,Hiroyuki Saito,Kazuyuki Takata　Regenerative Therapy　25　229　2024/03

Conference Presentations

Others

  • 　Multi Nuclides Simultaneous imaging with the Electron Tracking Compton Camera　KABUKI SHIGETO,KUBO HIDETOSHI,MIUCHI KENTARO,KIMURA HIROYUKI,AMANO HIROO,KAWASHIMA HIDEKAZU,UEDA MASASHI,NAKAMOTO YUJI,TOGASHI KORI,SAJI HIDEO,TANIMORI TORU　薬学雑誌　128　Suppl.1　48　2008/06/05
  • 　Development of the Imaging Probe Targeting Pancreatic GLP-1 Receptorsfor Noninvasive Detection of Pancreatic β-cell Mass　Yu Ogawa,Hiroyuki Kimura,Hidekazu Kawashima,Kentaro Toyoda,Eri Mukai,Hiroyuki Fujimoto,Konomu Hirao,Masahiro Ono,Nobuya Inagaki,Hideo Saji　AIMECS11　2011
  • 　N‐アセチルグルコサミン転移酵素Vの受容体基質となる三糖誘導体の合成研究　有光健治,木村寛之,梶本哲也,野出學　日本薬学会年会要旨集　129th　2　78　2009/03/05
  • 　Development of novel diphenyloxadiazole derivatives for imaging beta-amyloid plaques in Alzheimer's brain　Hiroyuki Watanabe,Masahiro Ono,Hiroyuki Kimura,Morio Nakayama,Hideo Saji　The 6th Seoul-Kyoto-Osaka Joint Symposium on Pharmaceutical Sciences for Young Scientists　2011/05
  • 　Role of PET imaging in gynecological tumors　T. Tsujikawa,T. Tsuchida,H. Kimura,Y. Yoshida,T. Kurokawa,Y. Kiyono,H. Okazawa　Japanese Journal of Clinical Radiology　56　730　2011/06/10

show all

  • 　Synthetic study of glycolipid analogs including trisaccharide　有光健治,加藤孝博,木村寛之,梶本哲也,野出學　複素環化学討論会講演要旨集　38th　249　2008/10/10
  • 　GnT‐Vを標的とした三糖誘導体の合成研究　有光健治,木村寛之,梶本哲也,野出學　日本薬学会年会要旨集　130th　2　97　2010/03/05
  • 　"Polymeric micelle type dual imaging probe for PET and optical imaging techniques "　Akira Makino,Ayaka Tomoike,Hiroyuki Kimura,Masahiro Ono,Goro Nishimura,Yasushi Kiyono,Hideo Saji　2014 World Molecular Imaging Congress　2014/09
  • 　Alveolar Epithelium Cellular Uptake of Nanoparticles Depending on Surface Modification and Potential　西岡 和久,松井 康人,木村 寛之　地球環境研究論文集 = Global environment engineering research : 地球環境シンポジウム　21　67　2013
  • 　2 価 99mTc 錯体を用いた脳アミロイドアンギオパチーの生体イメージング　Shimpei Iikuni　第12回次世代を担う若手のためのフィジカル・ファーマフォーラム　2014/07
  • 　Evaluation of Newly Synthesized 68Ga-Labeled Exendin-4 Derivative Targeting Glucagon-like Peptide-1 Receptor　Hiroyuki Kimura,Hirokazu Matsuda,Yu Ogawa,Kentaro Toyoda,Asami Kon,Masahiro Ono,Nobuya Inagaki,Hideo Saji　Society of Nuclear Medicine and Molecular Imaging 2013 Annual Meeting　2013/06
  • 　"Molecular imaging of b-amyloid plaques in Alzheimer’s disease with single photon emission computed tomography "　Watanabe H,Ono M,Kimura H,Saji H　The 37th naito Conference　2014/07
  • 　肝臓における有機アニオントランスポーター(OATP)イメージング剤[18F]PTV‐F1合成法の検討　加川信也,矢倉栄幸,西井龍一,東達也,山内浩,入野保,川井恵一,屋木祐亮,木村寛之,前田和哉,楠原洋之,小野正博,佐治英郎,杉山雄一　JSMI Rep　7　2　122　2014/05/15
  • 　腫瘍特異的に発現する酵素GnT‐Vを標的とした放射性イメージング剤の開発に向けた基礎的検討　有光健治,木村寛之,梶本哲也,天野博夫,三鴨睦,小野正博,向高弘,間賀田康寛,大桃善朗,野出學,山下正行,佐治英郎　日本薬学会年会要旨集　132nd　4　104　2012/03/05
  • 　Synthesis of N-terminal specific PET-probe labeling of peptides via the NEXT-A reaction　TOKUDA Yasunori,KIMURA Hiroyuki,SAIKI Hidekazu,TAKI Masumi,SAJI Hideo　2012　41　2013/03/01
  • 　EGFRの二次変異の識別を目的としたPETイメージングプローブの開発　奥田 悠,木村 寛之,牧野 顕,有光 健治,宮崎 杏奈,渡邊 裕之,川崎 郁勇,西出 喜代治,西井 龍一,小野 正博,佐治 英郎　第55回日本核医学会　2015/11
  • 　Alveolar Epithelium Cellular Uptake of Nanoparticles Depending on Surface Modification and Potential　NISHIOKA Kazuhisa,MATSUI Yasuto,KIMURA Hiroyuki,SAJI Hideo,YONEDA Minoru　Journal of Japan Society of Civil Engineers, Ser. G (Environmental Research)　69　5　I_67　2013
  • 　The Performance Estimation of Improved Electron Tracking Compton Camera (ETCC)　SONODA SHINYA,KUBO HIDETOSHI,SAWANO TATSUYA,MATSUOKA YOSHIHIRO,KOMURA SHOTARO,NAKAMURA SHOGO,YOSHITAKA MUZUMURA,MIZUMOTO TETSUYA,KABUKI SHIGETO,KIMURA HIROYUKI,TAKADA ATSUSHI,TANIMORI TORU　医学物理 Supplement　33　3　43　2013/09/16
  • 　The Performance Evaluation of The Electron Tracking Compton Camera　SONODA SHINYA,TANIMORI TORU,KUBO HIDETOSHI,SAWANO TATSUYA,MATSUOKA YOSHIHIRO,KOMURA SYOTARO,NAKAMURA SYOGO,MIZUMOTO TETSUYA,KABUKI SHIGETO,KIMURA HIROYUKI,TAKADA ATSUSHI　医学物理 Supplement　33　1　141　2013/04/01
  • 　The performance evaluation of the Electron Tracking Compton Camera　S. Sonoda,H. Kubo,T. Sawano,Y. Matsuoka,S. Komura,S. Nakamura,Y. Mizumura,T. Mizumoto,S. Kabuki,H. Kimura,A. Takada,T. Tanimori　IEEE Nuclear Science Symposium Conference Record　2013
  • 　[123I]IGLCE, A Novel Prostate Specific Membrane Antigen Targeting Probe for Prostate Cancer Imaging with SPECT　Harada N,Kimura H,Ono M,Saji H　The World Molecular Imaging Congress 2012　2012/09
  • 　1. Preemptive Medicine for Diabetes Mellitus　Inagaki Nobuya,Fujita Naotaka,Kimura Hiroyuki,Hamamatsu Keita,Sano Kohei,Hirai Mitsuharu,Murakami Atsushi,Saji Hideo,Fujimoto Hiroyuki　Nihon Naika Gakkai Zasshi　104　9　1803　2015
  • 　肝臓における有機アニオントランスポーター(OATP)イメージング剤[18F]PTV‐F1の臨床使用に向けた合成　西井龍一,加川信也,東達也,山内浩,川井恵一,屋木祐亮,木村寛之,小野正博,佐治英郎,杉山雄一　核医学　51　3　294　2014/09/30
  • 　Optical imaging of cerebral β-amyloid plaques with BODIPY-based molecular probes　Watanabe H,Ono M,Kimura H,Saji H　Alzheimer's Association International Conference 2012　2012/07
  • 　New Medical Imaging based on Electron Tracking Compton Camera (ETCC)　Tanimori Toru,Kubo Hidetoshi,Kabuki Shigeto,Kimura Hiroyuki　Japanese Journal of Medical Physics (Igakubutsuri)　32　3　111　2012
  • 　糖尿病膵臓内のアミリンを標的とした125I-, 18F-フェノキシメチルピリジン誘導体の合成と評価　吉村 優志,小野 正博,渡邊 裕之,木村 寛之,佐治 英郎　第55回日本核医学会　2015/11
  • 　Kinetics of Nanoparticles in Rats Using SPECT/CT Imaging　長尾 超,松井 康人,木村 寛之　環境衛生工学研究 : 京都大学環境衛生工学研究会機関誌　27　3　228　2013/07
  • 　Preemptive medicine for diabetes mellitus　稲垣 暢也,藤田 直尚,木村 寛之　日本内科学会雑誌　104　9　1803　2015/09/10
  • 　Cu-Mediated Radio-Iodination from Boronic Acid and Ester　近藤悠斗,木村寛之,屋木祐亮,屋木祐亮,樋口隆弘,樋口隆弘,安井裕之　日本薬学会年会要旨集(Web)　141st　2021
  • 　Development of the SPECT molecular imeging probe targeting for EphA2 recepter　古川武典,木村寛之,鳥本英恵,屋木祐亮,河嶋秀和,有光健治,安井裕之　日本薬学会年会要旨集(CD-ROM)　140th　2020
  • 　18F標識STZ誘導体の体内分布に関する基礎的評価　有光健治,木村寛之,屋木祐亮,佐治英郎,安井裕之　日本薬学会年会要旨集(CD-ROM)　138th　ROMBUNNO.28PA‐am102　2018
  • 　共振空洞型マイクロ波反応装置を用いた68Ga錯体形成反応の基礎評価　屋木祐亮,木村寛之,志水陽一,有光健治,中本裕士,富樫かおり,安井裕之　日本薬学会年会要旨集(CD-ROM)　138th　ROMBUNNO.27PA‐am313　2018
  • 　共振空洞型マイクロ波反応装置を用いたPET用有機アニオントランスポーターイメージングプローブの合成　屋木祐亮,木村寛之,大根田訓之,有光健治,安井裕之,佐治英郎　フッ素化学討論会講演要旨集　40th　130‐131　2017/11/14
  • 　Properties and biological effect of cationic PAMAM dendrimer nanoparticles　Kurokawa Yoshika,Win-Shwe Tin-Tin,Zeng Yang,Kimura Hiroyuki,Koyama Yosuke,Matsui Yasuto,Hirano Seishiro,Sone Hideko　Transactions of Japanese Society for Medical and Biological Engineering　54　28　S375　2016
  • 　脳アミロイドアンギオパチーイメージングを目的とした新規2価99mTc錯体の合成と評価　飯國 慎平,小野 正博,渡邊 裕之,木村 寛之,佐治 英郎　第55回日本核医学会　2015/11
  • 　含フッ素置換基を有するpyridopyrimidine誘導体の変異型EGFR‐TK阻害活性に関する構造活性相関研究　有光健治,有光健治,木村寛之,石黒真澄,高瀬里紗,辰巳莉菜,繁田尭,川崎郁勇,佐治英郎,安井裕之　メディシナルケミストリーシンポジウム講演要旨集　35th　234　2017/10/04
  • 　前立腺がんの術中診断のための非対称ウレア型近赤外蛍光プローブの開発　松岡 大航,渡邊 裕之,志水 陽一,木村 寛之,小野 正博,佐治 英郎　第15回次世代を担う若手のためのフィジカル・ファーマフォーラム　2017/09
  • 　造影ダイナミックCTとフッ素18フルオロミソニダゾール陽電子放出断層撮像法を用いた、腫瘍間質の評価および腫瘍低酸素との関連性の評価　子安 翔,辻 喜久,原田 浩,中本 裕士,野橋 智美,木村 寛之,佐野 紘平,小泉 幸司,濱路 政嗣,富樫 かおり　核医学　53　Suppl.　np2　2016/10
  • 　Plasma and Cancer　Masashi Ueda,Daiki Yamagami,Keiko watanabe,Asami Mori,Hiroyuki Kimura,Masaru Hori,Mounir Laroussi,Kai Masur,Yuzuru Ikehara　Plasma Processes and Polymers 12,No. 12　p.p. 1329-1469　2015/12/01
  • 　アルツハイマー病脳内タウの生体イメージングを目的とした新規放射性プローブの基礎的評価　渡邊 裕之,小野 正博,松村 憲志,木村 寛之,佐治 英郎　第55回日本核医学会　2015/11
  • 　18F製剤の設計と標識合成の基礎　木村寛之,有光健治,屋木祐亮　心臓核医学　20　2　29　2018/06/20
  • 　F‐18標識ボロン酸誘導体を用いた新規F‐18標識法の開発　屋木祐亮,有光健治,平野圭市,安井裕之,木村寛之　フッ素化学討論会講演要旨集　41st　111‐112　2018/10/25
  • 　有機アニオントランスポーター(OATPs)を標的としたPETイメージングプローブの開発:[18F]pitavastatinの合成と評価　屋木祐亮,木村寛之,前田和哉,有光健治,安井裕之,杉山雄一,杉山雄一,佐治英郎　メディシナルケミストリーシンポジウム講演要旨集　35th　278　2017/10/04
  • 　放射性フッ素標識ストレプトゾトシン誘導体の合成研究　有光健治,屋木祐亮,木村寛之,安井裕之　フッ素化学討論会講演要旨集　40th　136‐137　2017/11/14
  • 　Kinetic Analysis of radiolabeled nanoparticles in mouse organs　近藤 真司,松井 康人,米田 稔,木村 寛之　環境衛生工学研究 = Environmental & sanitary engineering research : 京都大学環境衛生工学研究会機関誌　30　3　90　2016/07
  • 　核医学的手法を用いた薬剤性腎障害の評価法の開発　松岡 大航,木村 寛之,渡邊 裕之,小野 正博,佐治 英郎　日本薬学会 第136年会　2016/03
  • 　造影ダイナミックCTとフッ素18フルオロミソニダゾール陽電子放出断層撮像法を用いた、腫瘍間質の評価および腫瘍低酸素との関連性の評価　子安 翔,辻 喜久,原田 浩,中本 裕士,野橋 智美,木村 寛之,佐野 紘平,小泉 幸司,濱路 政嗣,富樫 かおり　JSMI Report　10　1　63　2016/12
  • 　Development of the novel F-18 labeling method using Suzuki coupling reaction with F-18 labeled boronic acid derivatives　屋木祐亮,屋木祐亮,屋木祐亮,近藤悠斗,樋口隆弘,木村寛之　日本薬学会年会要旨集(Web)　142nd　2022
  • 　Evaluation of transplanted islets using molecular imaging technology　田中未紗,木村寛之,宮本佳美,桶谷亮,河嶋秀和,安井裕之　日本薬学会年会要旨集(CD-ROM)　140th　2020
  • 　放射性標識ストレプトゾトシン誘導体の合成研究　有光健治,木村寛之,佐治英郎,安井裕之　日本薬学会年会要旨集(CD-ROM)　137th　ROMBUNNO.26PA‐pm119　2017
  • 　Prostate Specific Membrane Antigenを標的とした前立腺がん核医学診断用放射性金属核種99mTc標識プローブの開発　松岡 大航,木村 寛之,原田 直弥,三平 崇太郎,渡邊 裕之,小野 正博,佐治 英郎　第26回金属の関与する生体関連反応シンポジウム　2016/06
  • 　薬剤性腎障害の核医学分子イメージングの標的としての prostate-specific membrane antigen の可能性　松岡 大航,木村 寛之,渡邊 裕之,小野 正博,佐治 英郎　第11回日本分子イメージング学会総会・学術集会　2016/05
  • 　Development of pitavastatin derivatives for in vivo PET imaging of organic anion transporting polypeptides　屋木祐亮,屋木祐亮,屋木祐亮,木村寛之,木村寛之,前田和哉,小野正博,楠原洋之,安井裕之,佐治英郎　日本薬学会年会要旨集(CD-ROM)　140th　2020

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