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Researcher Information

last modified：2024/11/21

Associate Professor　NAKAGAWA-GOTO Kyoko

Laboratory Website
Laboratory Website

Faculty, Affiliation

Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences

College and School Educational Field

Graduate School of Natural Science and Technology
School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences
School of Pharmacy, College of Medical, Pharmaceutical and Health Sciences

Laboratory

Natural Products and Medicinal Chemistry　TEL:076-264-6305

Academic Background

【Academic background(Bachelor's Degree)】
Kanazawa University
【Degree】
Ph.D.

Career

WPI Nano Life Science Institutre, Kanazawa Univeristy(2024/06/01-)
University of North Carolina at Chapel Hill　Eshelman School of Pharmacy　Adjuct Associate Professor(2012/04/01-)
The University of North Carolina at Chapel Hill　School of Pharmacy　Research Associate Professor, (2011/03/01-2012/03/31)
The University of North Carolina at Chapel Hill　School of Pharmacy　Research Assistant Professor(2006/08/01-2011/02/28)
Post-doctoral Research Associate, The University of North Carolina at Chapel Hill　School of Pharmacy(2002/07/01-2006/07/31)
Post-doctoral Research Associate, The University of North Carolina at Chapel Hill　Department of Chemistry(1998/10/01-2002/04/30)
Assistant Professor, Kanazawa University　School of Pharmacy(1990/04/01-1998/09/30)
Research Assistant, Kanazawa University　School of Pharmacy(1985/04/01-1990/03/31)
Visiting Scientist, The University of California at Berkeley 　Department of Chemistry(1996/03/01-1996/07/31)

Year & Month of Birth

Academic Society




Award


○University Research Council Research Award　（UNC)(2007/12/01)
○Uehara Foundation International Fellowship (1998/10/01)

Specialities

Drug development chemistry、Natural medicines、Drug development chemistry

Speciality Keywords

Organic Chemistry,Medicinal Chemistry,Natural Product Chemistry

Research Themes

Discovery and development of drug candidates based on bioactive natural products

Books

  • 　Antitumor and Anti-HIV Agents from Natural Products　‎Mdpi AG　2020/09/16

Papers

  • 　Isolation, Characterization, and Antiproliferative Activity of Terpenoids from the Tropical Plant Turraea delphinensis　Kouno H, Amuti S, Miyake K, Fukuyoshi S, Saito Y, Goto M, Newman DJ, O’Keefe BR, Lee KH, Nakagawa-Goto K　Journal of Natural Products　ASAP　2024/07/06　
  • 　 Cyclic sesquiterpene-flavanone [4+2] hybrids, Syzygioblanes A–C, found in an Indonesian traditional medicine, 'Jampu Salo' (Syzygium oblanceolatum) 　Koga N, Saito Y, Miyake K, Amuti S, Fukuyoshi S, Yoshida S, Sato S, Yamada Y, Ikeda A, Adachi N, Kawasaki M, Takasu A, Aramaki S, Senda T, Rahim A, Najib A, Alam G, Tanaka N, Nakagawa-Goto K,　Organic Letters　26　4302-4307　2024/05/10　
  • 　Total Synthesis of a TNBC-selective Cytotoxic Bromo Nor-eremophilane, PC-A, and Its Preliminary Structure-activity Relationships　Maeda S, Nakayama W, Saito Y, Sagano M, Goto M, Nakagawa-Goto K　Journal of Natural Products　87　861-868　2024/03/06　
  • 　Unusual Vilasinin-Class Limonoids from Trichilia rubescens　Amuti S, Saito Y, Fukuyoshi S, Miyake K, Newman DJ, O’keefe BR., Lee, KH, Nakagawa-Goto K　Molecules　29　651　2024/01/30　
  • 　Caged Xanthones and Biphenyls Isolated from the Tropical Plant Garcinia lateriflora.　Ayano Kobayashi,Yohei Saito,Katsunori Miyake,Shuichi Fukuyoshi,David J Newman,Barry R O'Keefe,Kuo-Hsiung Lee,Kyoko Nakagawa-Goto　Journal of natural products　2024/01/22

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  • 　Total synthesis of waltherinone A, a qunoline alkaloids fused with oxabicyclo[3.2.1]octane　Shimoi R, Miura Y, Saito Y, Nakagawa-Goto K　Organic Letters　25　4755-4758　2023/06/22　
  • 　Novel α-Trifluoromethyl Chalcone Exerts Antitumor Effects Against Prostate Cancer Cells.　Takafumi Shimada,Renato Naito,Ren Toriumi,Ryunosuke Nakagawa,Shuhei Aoyama,Taiki Kamijima,Hiroshi Kano,Suguru Kadomoto,Hiroaki Iwamoto,Hiroshi Yaegashi,Kouji Izumi,Yoshifumi Kadono,Hiroki Nakata,Yohei Saito,Kyoko Nakagawa-Goto,Atsushi Mizokami　Anticancer research　43　6　2433　2023/06
  • 　A New Bis-indole Alkaloid, Spermaocymine A, and an Anthraquinone from Spermacoce ocymoides.　Abdul Rahim,Saidanxia Amuti,Ahmad Najib,Katsunori Miyake,Yohei Saito,Kyoko Nakagawa-Goto　Chemical & pharmaceutical bulletin　71　5　380　2023
  • 　MicroRNA-mediated mitochondrial dysfunction is involved in the anti-triple-negative breast cancer cell activity of phytosesquiterpene lactones　Cheng YT, Nakagawa-Goto K, Lee KH, Shyur LF　Antioxid. Redox Signal　38　198　2023/01/16　
  • 　Suppression of androgen receptor signaling induces prostate cancer migration via activation of the CCL20–CCR6 axis　Cancer Science　114　1479　2023/01/01　
  • 　Synthesis of a model compound of the unique meroterpenoids cryptolaevilactones　Miura Y, Saito Y, Nakagawa-Goto K　Chem. Pharm. Bull　70　10　740-747 　2022/07/27　
  • 　Phyto-sesquiterpene lactones DET and DETD-35 induce ferroptosis in vemurafenib resistant melanoma via GPX4 inhibition and metabolic reprogramming　Chang MT, Tsai LC, Nakagawa-Goto K, Lee KH, Shyur LF　Pharmacology Research　178　106148　2022/02/26　
  • 　Chemical Space Expansion of Flavonoids: Induction of Mitotic Inhibition by Replacing Ring B with a 10π-Electron System, Benzo[b]thiophene　Hirazawa S, Saito Y, Sagano M, Goto M, Nakagawa-Goto K　Journal of Natural Products　85　1　136–147　2022/01/14　
  • 　 Isolation and Characterization of Stigmasterol and β-sitosterol from Plectranthus scutellarioides var. color blaze dark star and Cytotoxicity of Its Fraction　 Egypt. J. Chem.　65　255-260　2021/10/03
  • 　Boroxazolidone formation under physiological conditions toward chemical modification of biomolecules　Saito Y, Yoshida N, Nakagawa-Goto K　Chemistry Letters　2021/07/01　
  • 　Synthesis of Thio-lignane Analogue, Bioequivalent Salvinal without Unfavored Aldehyde　Saito Y, Kobayashi Y, Yoshida N, Goto M, Nakagawa-Goto K　Journal of Organic Chemistry　86　7092-7106　2021/05/13　
  • 　α-Trifluoromethyl Chalcones as Potent Anticancer Agents for Androgen Receptor-Independent Prostate Cancer,　Saito Y, Mizokami A, Izumi K, Naito R, Goto M, Nakagawa-Goto K　Molecules　26　2813　2021/05/10　
  • 　Sesquiterpene Lactone Deoxyelephantopin Isolated from Elephantopus scaber and its Derivative DETD-35 Suppress BRAFV600E Mutant Melanoma Lung Metastasis in Mice　Cvetanova B, Li MY, Yang CC, Hsiao PW, Yang YC, Feng JH, Shen YC, Nakagawa-Goto K, Lee KH, Shyur LF　International Journal of Molecular Sciences　22　3226　2021/04/18　
  • 　Bicyclic Chalcones as Mitotic Inhibitors for Overcoming Androgen Receptor-Independent and Multidrug Resistant Prostate Cancer　Saito Y, Mizokami M, Maeda S, Takahashi K, Izumi K, Goto M, Nakagawa-Goto K　ACS Omega　6　4842-4849　2021/02/09　
  • 　A new flavonoid derivative exerts anti-tumor effects against androgen-sensitive to cabazitaxel-resistant prostate cancer cells　Naito R, Kano H, Shimada T, Makino T, Kadomoto S, Iwamoto H, Yaegashi H, Izumi K, Kadono Y, Nakata H, Saito Y, Goto M, Nakagawa-Goto K, Mizokami A　The Prostate　81　5　295-306　2021/01/25　
  • 　Anti-proliferative and anti-migratory properties of coffee diterpenes kahweol acetate and cafestol in human renal cancer cells　Izumi K, Makino T, Hiratsuka K, Kano H, Shimada T, Nakano T, Kadomoto S, Naito R, Iwamoto H, Yaegashi H, Shigehara K, Kadono Y, Nakata H, Saito Y, Nakagawa-Goto K, Mizokami A.　Scientific Reports　11　675　2021/01/12　
  • 　Development of an Efficient Scale-up Synthesis Method for β3-Adrenergic Receptor Agonist, Ritobegron Ethyl Hydrochloride　Sonehara J, Tamai T, Isawa H, Hotei Y, Kasai K, Kikuchi N, Ishikawa T, Kobayashi M, Ozawa T, Suzuki R, Kobayashi M, Ainai T, Nishimura M, Saito Y, Nakagawa-Goto K　Organic Process Research & Development　24　9　1675-1682　2020/07/31　
  • 　The anticancer activity of two glycosides from the leaves of Leea aequata L.　Rahim A, Mostofa MG, Sadik MG, Rahman MAA, Khalil MI, Tsukahara T, Nakagawa-Goto K, Alam AHMK　Natural Product Research　2020/07/27
  • 　First Total Synthesis of a Pavine Alkaloid, (±)-Neocaryachine, and its Optical Resolution　Miura Y, Saito Y, Nakagawa-Goto K　Chem. Pharm. Bull.　68　9　899–902　2020/06/01　
  • 　Palasanines A-E, 3,4-Methylenedioxyquinoline Alkaloids Fused with a Phenyl-14- oxabicyclo[3.2.1]octane Unit from Melochia umbellata var. deglabrata　Rahim A, Saito Y, Fukuyoshi S, Miyake K, Goto M, Chen CH, Alam G, Lee KH, Nakagawa-Goto K　Journal of Natural Products　83　10　2931-2939　2020　
  • 　Novel Furoquinolinones from an Indonesian Plant, Lunasia amara　Yamashita M, Saito Y, Rahim A, Fukuyoshi S, Miyake K, Goto M, Nakagawa-Goto K　Tetrahedron Letters　61　20　151861　2020/03/24　
  • 　Tumor-associated macrophages induce migration of renal cell carcinoma cells via activation of the CCL20-CCR6 axis　Kadomoto S, Izumi K, Hiratsuka K, Nakano T, Naito R, Makino T, Iwamoto H, Yaegashi H, Shigehara K, Kadono Y, Nakata H, Saito Y, Nakagawa-Goto K, Mizokami A　Cancers　12　89　2019/12/30　
  • 　Isolation, Structure Elucidation, and Antiproliferative Activity of Butanolides and Lignan Glycosides from the Fruit of Hernandia peltata　Aimaiti S, Saito Y, Fukuyoshi S, Goto M, Miyake K, Newman DJ, O’Keefe BR, Lee KH, Nakagawa-Goto K　Molecules　24　4005　2019/11/01
  • 　Prenylated acetophloroglucinol dimers from Acronychia trifoliolata: Structure elucidation and total synthesis　Miyake K, Morita C, Suzuki A, Matsushita N, Saito Y, Goto M, Newman DJ, O’Keefe BR, Lee KH, Nakagawa-Goto K　Journal of Natural Products　82　2852　2019/09/24　
  • 　Spiro[3.5]nonenyl meroterpenoid lactones, cryptolaevilactones G–L, an ionone derivative and total synthesis of cryptolaevilactone M from Cryptocarya laevigata　Tsurumi F, Yuta Miura, Nakano M, Saito Y, Fukuyoshi S, Newman DJ, O’Keefe BR, Lee KH, Nakagawa-Goto K.　Journal of Natural Products　2019/08/23　
  • 　Synthesis of 4-epi-Parviflorons A, C and E: Structure-Activity Relationship Study of Antiproliferative Abietane Derivatives　Miyajima Y, Takeya M, Saito Y, Goto M, Nakagawa-Goto K　Journal of Organic Chemistry　84　3239　2019/02/22　
  • 　Synthesis of 1-methoxyindoles and related analogs of pimprinine, (±)-chelonin A and B, based on 1-hydroxyindole chemistry　Aoki K, Nagahama Y, Sugaya K, Maeda Y, Sato H, Nakagawa(Goto) K, Somei M　Heterocycles　98　236-270　2019/02/13
  • 　Anti-proliferative and chemosensitizing effects of diarylheptanoids on human tumor cell lines　Miyagishi S, Saito Y, Goto M, Nakagawa-Goto K　ACS Omega　4　2053–2062　2019/01/26　
  • 　Coffee diterpenes kahweol acetate and cafestol synergistically inhibit the proliferation and migration of prostate cancer cells　Iwamoto H, Izumi K, Netsagdorj A, Naito R, Makino T, Kadomoto S, Hiratsuka K, Shigehara K, Kadono Y, Narimoto K, Saito Y, Nakagawa-Goto K, Mizokami A.　The Prostate　1–12　2018/12/19　
  • 　5’-Chloro-2,2’-dihydroxychalcone and Related Flavanoids as Treatments for Prostate Cancer　Saito Y, Mizokami A, Tsurimoto H, Izumi K, Goto M, Nakagawa-Goto K.　European Journal of Medicinal Chemistry　157　1143-1152　2018/08/28　
  • 　Antiproliferative alkaloids from Alangium longiflorum, an endangered tropical plant species　Takeuchi M, Saito Y, Goto M, Miyake K, Newman DJ, O’Keefe BR, Lee KH, Nakagawa-Goto K　Journal of Natural Products　81　1884-1891　2018/08/14　
  • 　Kleinhospitine E and cycloartane triterpenoids from Kleinhovia hospita L.　Rahim A, Saito Y, Miyake K, Goto M, Chen CH, Alam G, Morris-Natchke S, Lee KH, Nakagawa-Goto K.　Journal of Natural Products　81　1619–1627　2018/07/17　
  • 　Secondary metabolites, monoterpene-polyketides containing a spiro[3.5]nonane from Cryptocarya laevigata,　Tsurumi F, Miura Y, Saito Y, Miyake K, Fujie T, Newman DJ, O’Keefe BR, Lee KH, Nakagawa-Goto K,　Organic Letters　20　2282–2286　2018/04/03　
  • 　Total synthesis of antiproliferative parviflorone F　Saito Y, Goto M, Nakagawa-Goto K　Organic Letters　20　628　2018/01/18　
  • 　Corymbulosins I–W, Cytotoxic clerodane diterpenes from the bark of Laetia corymbulosa　Aimaiti S, Suzuki A, Saito Y, Fukuyoshi S, Goto M, Miyake K, Newman DJ, O’Keefe BR, Lee KH, Nakagawa-Goto K.　Journal of Organic Chemistry　83　951　951　2018/01/01　
  • 　Phytoagent Deoxyelephantopin and Its Derivative Inhibit Triple Negative Breast Cancer Cell Activity through ROS-Mediated Exosomal Activity and Protein Functions　12. Shiau JY, Chang YQ, Nakagawa-Goto K, Lee KH, Shyur LF　Frontiers in Pharmacology　8　1-15　2017/06/04　
  • 　Phytoagent deoxyelephantopin derivative inhibits triple negative breast cancer cell activity by inducing oxidative stress-mediated paraptosis-like cell death　Shiau JY, Nakagawa-Goto K, Lee KH, Shyur LF　Oncotarget　2017/04/19　
  • 　Antitubulin effects of aminobenzothiophene-substituted triethylated chromones　Kobayashi Y, Saito Y, Goto M, Nakagawa-Goto K　BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　2017/04/17　
  • 　Corymbulosins D–H, 2-Hydroxy- and 2-Oxo-clerodane Diterpenes from the Bark of Laetia corymbulosa 　Suzuki A, Saito Y, Fukuyoshi S, Goto M, Miyake K, Newman DJ, O’Keefe BR, Lee KH, Nakagawa-Goto K.　JOURNAL OF NATURAL PRODUCTS　80　1065-1072　2017/03/14　
  • 　(-)-Neocaryachine, an antiproliferative pavine alkaloid from Cryptocarya laevigata induces DNA double-strand breaks.　Suzuki Y, Saito Y, Goto M, Newman D, O'Keefe B, Lee KH, Nakagawa-Goto K　JOUNAL OF NATURAL PRODUCTS　80　220　2017/01/15　
  • 　A Novel Clerodane Diterpene from Vitex cofassus　Rasyid FA, Fukuyoshi S, Ando H, Miyake K, Atsumi T, Fujie T, Saito Y, Goto M, Shinya T, Mikage M, Sasaki, Nakagawa-Gotoa K.　CHEMICAL AND PHARMACEUTICAL BULLETIN　65　116–120　2016/10/30　
  • 　Total synthesis and in vitro anti tumor-promoting activity of racemic acetophenone monomers from Acronychia trifoliolata　Morita C, Kobayashi Y, Tokuda H, Saito Y, Miyake M, Suzuki N, Ichiishi E, Lee KH, Nakagawa-Goto K　JOURNAL OF NATURAL PRODUCTS　79　2890–2897　2016/10/26　
  • 　Acetophenone monomers from Acronychia trifoliolata　Miyake M, Suzuki A, Morita C, Goto M, Newman DJ, O’Keefe B, Morris-Natschke SL, Lee KH, Nakagawa-Goto K　JOURNAL OF NATURAL PRODUCTS　79　2883–2889　2016/10/14　
  • 　Triethylated chromones with substituted naphthalenes as novel tubulin inhibitors　Nakagawa-Goto K, Taniguchi Y, Watanabe Y, Oda A, Ohkoshi E, Hamel E, Lee KH, Goto M　BIOORGANIC MEDICINAL CHEMISTRY　24　6048–6057　2016/10/02　
  • 　Phenylethylchromones with in vitro antitumor promoting activity from Aquilaria filarial　Suzuki A, Miyake K, Saito Y, Faradiba, Tokuda H, Takeuchi M, Suzuki N, Ichiishi E, Fujie T, Goto M, Sasaki S, Nakagawa-Goto K　Planta Medica　83　300　2016/06/16　
  • 　Novel sesquiterpene lactone analogues as potent anti-breast cancer agents　Nakagawa-Goto K, Chen JY,　Cheng YT, Lee WL, Takeya M, Saito Y, Lee KH, Shyur LF　Mol. Oncol.　10　921–937　2016　
  • 　A novel plant sesquiterpene lactone derivative DETD-35 suppresses BRAFV600E mutant melanoma growth and overcomes acquired vemurafenib resistance in mice　Feng JH, Nakagawa-Goto K, Lee KH, Shyur LF.　Mol. Cancer Ther.　15　1163–1176　2016　
  • 　Development of a novel class of tubulin inhibitor from desmosdumotin B with a hydroxylated bicyclic B-ring　Nakagawa-Goto K,* Oda A, Hamel E, Ohkoshi E, Bastow KF, Lee KH, Goto M.*　JOURNAL OF MEDICINAL CHEMISTRY　2015　
  • 　 A-ring modified betulinic acid derivatives as cancer preventive agents.　Hung HY, Nakagawa-Goto K, Tokuda H, Iida A, Suzuki N, Qian K, Lee KH　BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　24　3　1005　2014/01
  • 　Isolation, Structure Determination, and Anti-HIV Evaluation of Tigliane-Type Diterpenes and Biflavonoid from Stellera chamaejasme　1. Asada Y, Sukemori A, Watanabe T, Malla K, Yoshikawa T, Li Wei, Kuang X, Koike K, Chen CH, Akiyama T, Qian K, Nagakawa-Goto K, Morris-Natschke S, Lu Y, Lee KH.　JOURNAL OF NATURAL PRODUCTS　76　5　852　2013/05
  • 　1-(3,4,5-Trimethoxyphenyl)ethane-1,2-diyl esters, a novel compound class with potent chemoreversal activity　Hung HY, Ohkoshi E, Goto M, Nakagawa-Goto K, Lee KH. 　BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　22　24　7726　2012/10
  • 　Antitumor Agents 293. Non-toxic Dimethyl-4,4′-dimethoxy-5,6,5′,6′-dimethylenedioxybiphenyl-2,2′-dicarboxylate (DDB) Analogs Chemosensitize Multidrug Resistant Cancer Cells to Clinical Anticancer Drugs　Hung HY, Ohkoshi E, Goto M, Bastow KF, Nakagawa-Goto K, Lee KH　JOURNAL OF MEDICINAL CHEMISTRY　2012/05
  • 　Design and synthesis of gambogic acid analogs as potent cytotoxic and anti-inflammatory agents. 　Yen CT, Nakagawa-Goto K, Hwang TL, Morris-Natschke SL, Bastow KF, Wu YC, Lee KH　BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　22　4018　2012/04
  • 　Antitumor agents 289. Design, Synthesis, and In Vivo Anti-Brest Cancer Activity of 4-Amino-2H-benzo[h]chromen-2-one Analogs (ABO) and 4-Amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one Analogs (ATBO) with Improved Water Solubility　Dong Y, Nakagawa-Goto K, Lai CY, Morris-Natschke SL, Bastow KF, Lee KH　JOURNAL OF NATURAL PRODUCTS　75　370　2012/02
  • 　Antitumor Agents 291 Expanded B-Ring Modification Study of 6,8,8-Triethyl Desmosdumotin B Analogues as Multidrug-Resistance Selective Agents　Nakagawa-Goto K, Bastow KF, Ohkoshi E, Morris-Natschke SL, Lee KH　Med. Chem.(Open access journal)　2011/12
  • 　Toward the Total Synthesis of Bryostatin 11: Stereoselective Construction of the C13-Exocyclic Enoate in the C1-C16 Fragment　Nakagawa-Goto K, Crimmins MT　SYNTHETIC COMMUNICATIONS　41　3032　2011/06
  • 　Stelleralides A-C, Novel Potent Anti-HIV Daphnane-Type Diterprnoids from Stellera Chamaejaseme　Asada Y, Sukemori A, Watanabe T, Malla KJ, Yoshikawa T, Li W, Koike K, Chen CH, Akiyama T, Qian K, Nakagawa-Goto K, Morris-Natschke SL, Lee KH　ORGANIC LETTERS　13　2904　2011/05
  • 　A unique P-glycoprotein interacting agent displays anticancer activity against hepatocellular carcinoma through inhibition of GRP78 and mTOR pathways　Kuo TC, Chiang PC, Yu CC, Nakagawa-Goto K, Bastow KF, Lee KH, Guh JH　BIOCHEMICAL PHARMACOLOGY　81　1136　2011/03
  • 　Antitumor agents 287. Substituted 4-Amino-2H-pyran -2-one Analogs (APO) Reveal a New Scaffold from Neo-tanshinlactone with In Vitro Anticancer Activity　Dong Y, Nakagawa-Goto K, Lai CY, Morris-Natschke SL, Bastow KF, Lee KH　BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　21　2341　2011/03
  • 　Synthetic Approaches to the Bottom Half Fragment for Bryostatin 11　Nakagawa-Goto K, Crimmins MT　SYNLETT　11　1555　2011/02
  • 　Antitumor Agents 284. A New Desmosdumotin B Analogue with Bicyclic B-ring as Cytotoxic and Antitubulin Agent　Nakagawa-Goto K,* Wu PC, Lai CY, Hamel E, Zhu H, Zhang L, Kozaka T, Ohkoshi E, Goto M, Bastow KF, Lee KH　JOURNAL OF MEDICINAL CHEMISTRY　54　1244　2011/02
  • 　Formal Synthesis of the Bryostatin Northern Hemisphere: Asymmetric Synthesis of the B-ring and C(1)-C(9) Fragment　Nakagawa-Goto K, Crimmins MT　SYNLETT　10　1413　2011/01
  • 　Antitumor Agents 283. Synthesis and Biological Evaluation of Desmosdumotin C Analogs as Potent Antitumor Agents　Nakagawa-Goto K,* Wu PC, Bastow KF, Chen HY, Lin JC, Wen H, Yang J, Goto M, Morris-Natschke SL, Yang PC, Lee KH　BIOORGANIC & MEDICINAL CHEMISTRY　19　1816　2011/01
  • 　Antitumor agents 281.Design, Synthesis, and Biological Activity of Substituted 4-Amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one Analogs (ATBO) as In Vitro Anticancer Agents　Dong Y, Nakagawa-Goto K, Lai CY, Morris-Natschke SL, Bastow KF, Lee KH　BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　21　546　2011/01
  • 　Antitumor agents 279. Structure-Activity Relationship and In Vivo Studies of Novel 2-(Furan-2-yl)naphthalen-1-ol (FNO) Analgos as Potent and Selective Anti-Breast Cancer Agents　Dong Y, Nakagawa-Goto K, Lai CY, Kim Y, Morris-Natschke SL, Lee EYHP, Bastow KF, Lee KH　BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　21　52　2011/01
  • 　Antitumor Agents 280. MDR-Selective Desmosdumotin B Analogues　Nakagawa-Goto K,* Chang PC, Lai CY, Hung HY, Chen TH, Wu PC, Zhu H, Sedykh A, Bastow KF, Lee KH　JOURNAL OF MEDICINAL CHEMISTRY　53　6699　2010/08
  • 　Antitumor Agents 282. 2’-(R)-O-Acetylglaucarubinone, a Novel Quassinoid from Odyendyea gabonensis as a Potent Anti-breast and Anti-ovarian Cancer Agent　Usami Y, Nakagawa-Goto K, Lang JY, Kim Y, Lai CY, Goto M, Sakurai N, Taniguchi M, Akiyama T, Morris-Natsucke SL, Bastow KF, Cragg G, Newman DJ, Fujitake M, Takeya K, Hung MC, Lee EYH P, Lee KH　JOURNAL OF NATURAL PRODUCTS　73　1553　2010/08
  • 　Antitumor agents 278. 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs as potent in vitro anti-cancer agents　Dong Y, Nakagawa-Goto K, Lai CY, Morris-Natschke SL, Bastow KF, Lee KH　BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　20　4085　2010/05
  • 　Antitumor agents 273. Design and synthesis of N-alkyl-thiocolchicinoids as potential antitumor agents　Kozaka T, Nakagawa-Goto K, Shi Q, Lai CY, Hamel E, Bastow KF, Brossi A, Lee KH　BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　20　4091　2010/05
  • 　Cancer Preventive Agents 10. Chemopreventive Potential of Dehydrozingerone Analogs　Tatsuzaki J, Nakagawa-Goto K, Tokuda H, Lee KH　JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH　12　227　2010/03
  • 　Antitumor Agents. 272. Structure−Activity Relationships and In Vivo Selective Anti-Breast Cancer Activity of Novel Neo-tanshinlactone Analogues. 　Dong Y, Shi Q, Pai HC, Peng CY, Pan SL, Teng CM, Nakagawa-Goto K, Yu D, Liu YN, Wu PC, Bastow KF, Morris-Natschke SL, Brossi A, Lang JY, Hsu JL, Hung MC, Lee EYHP, Lee KH　JOURNAL OF MEDICINAL CHEMISTRY　53　2299　2010/02
  • 　Antitumor Agents 271. Total Synthesis and Evaluation of Brazilein and Analogs as Anti-inflammatory and Cytotoxic Agents　Yen CT, Nakagawa-Goto K, Hwang TL, Wu PC, Morris-Natschke SL, Lai WC, Bastow KF, Chang FR, Wu YC, Lee KH　BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　20　1037　2010/01
  • 　Antitumor Agents 270. Novel Substituted 6-Phenyl-4H-furo[3,2-c]pyran-4-one Derivatives as Potent and Highly Selective Anti-Breast Cancer Agents　Dong Y, Shi Q, Nakagawa-Goto K, Wu PC, Morris-Natschke SL, Brossi A, Bastow KF, Lang JY, Hung MC, Lee KH　BIOORGANIC & MEDICINAL CHEMISTRY　18　803　2010/01
  • 　Antitumor Agents 269. Non-aromatic ring-A neotanshinlactone analog, TNO, as a new class of potent antitumor agents　Dong Y, Shi Q, Nakagawa-Goto K, Wu PC, Bastow KF, Morris-Natschke SL, Lee KH　BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　19　6289　2009/09
  • 　Cancer Preventive Agents 9. Cancer Chemopreventive Effects of Betulinic Acid Derivastives　Nakagawa-Goto K, Yamada K, Tokuda H, Lee KH　BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　19　3378　2009/05
  • 　Cytotoxic calanquinone A from Calanthe arisanensis and its first total synthesis　Lee CL, Nakagawa-Goto K, Yu D, Liu YN, Bastow KF, Morris-Natschke SL, Chang FR, Wu YC, Lee KH　BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　18　4275　2008/07
  • 　Antitumor Agents 260. New Desmosdumotin B Analogs with Improved Anticancer Activity　Nakagawa-Goto K, Bastow KF, Chen TH, Morris-Natschke SL, Lee KH　JOURNAL OF MEDICINAL CHEMISTRY　51　3297　2008/05
  • 　Anti-AIDS agents 73: Structure-activity relationship study and asymmetric synthesis of 3-O-monomethylsuccinyl-betulinic acid derivatives　Qian K, Nakagawa-Goto K, Yu D, Morris-Natschke SL, Theodore NJ, Kilgore N, Allaway GP, Lee KH　BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　17　6553　2007/09
  • 　Cancer Preventive Agents. 7. Antitumor-Promoting Effects of Seven Active Flavonolignans from Milk Thistle (Silybum marianumI) on Epstein-Barr Virus Activation　Lin AS, Shibano M, Nakagawa-Goto K, Tokuda H, Itokawa H, Morris-Natschke SL, Lee KH　PHARMACEUTICAL BIOLOGY　45　10　735　2007/07
  • 　First Total Synthesis of Protoapigenone and its Analogs as Potent Cytotoxic Agents　Lin AS, Nakagawa-Goto K, Chang FR, Yu D, Morris-Natschke SL, Wu CC, Chen SL, Wu YC, Lee KH　JOURNAL OF MEDICINAL CHEMISTRY　50　3921　2007/07
  • 　Antitumor Agents 258. Syntheses and Evaluation of Dietary Antioxidant Taxoid Conjugates as Novel Cytotoxic Agents　Nakagawa-Goto K, Yamada K, Nakamura S, Chen TH, Bastow KF, Wang SC, Hung MC, Lee FY, Lee FC, Lee KH　BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　17　5204　2007/07
  • 　Antitumor Agents 253. Design, Synthesis, and Antitumor Evaluation of Novel 9-Substituted Phenanthrene-Based Tylophorine Derivatives as Potential Anticancer Agents　Wei L, Shi Q, Bastow KF, Brossi A, Morris-Natschke SL, Nakagawa-Goto K, Wu TS, Pan SL, Teng CM, Lee KH　JOURNAL OF MEDICINAL CHEMISTRY　50　3674　2007/06
  • 　Antitumor Agents 259. Designs, Syntheses and Structure-Activity-Relationship Study of Desmosdumotin C Analogs　Nakagawa-Goto K, Chen TH, Peng CY, Bastow KF, Wu JH, Lee KH　JOURNAL OF MEDICINAL CHEMISTRY　50　3354　2007/06
  • 　Antitumor Agents 255. Novel Glycyrrhetinic Acid-Dehydrozingerone Cinjugates as Cytotoxic Agents 　Tatsuzaki J, Taniguchi M, Bastow KF, Nakagawa-Goto K, Morris-Natschke SL, Itokawa H, Baba K, Lee KH　BIOORGANIC & MEDICINAL CHEMISTRY　15　6193　2007/06
  • 　Antitumor Agents 256. Conjugation of Paclitaxel with Other Antitumor Agents: Evaluation of Novel Conjugates as Cytotoxic Agents　Nakagawa-Goto K, Nakamura S, Bastow KF, Nyarko A, Peng CY, Lee FY, Lee FC, Lee KH　BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　17　2894　2007/02
  • 　Anti-HIV Agents 68: The First Total Synthesis of a Unique Potent Anti-HIV Chalcone from Genus Desmos　Nakagawa-Goto K, Lee KH　TETRAHEDRON LETTERS　47　8263　2006/09
  • 　Dehydrozingerone, Chalcone, Isoeugenol Analogues as in vitro Anticancer Agents　Tatsuzaki J, Bastow KF, Nakagawa-Goto K, Nakamura S, Itokawa H, Lee KH　JOURNAL OF NATURAL PRODUCTS　69　1445　2006/09
  • 　Antitumor Agents 254: Synthesis and Biological Evaluation of Novel Neo-tanshinlactone Analogs as Potent Anti-breast Cancer Agents　Wang X, Nakagawa-Goto K, Bastow KF, Don MJ, Lin YL, Wu TS, Lee KH　JOURNAL OF MEDICINAL CHEMISTRY　49　5631　2006/08
  • 　Cytotoxic Alangium Alkaloids from Alangium longiflorum　Sakurai N, Nakagawa-Goto K, Ito J, Sakurai Y, Nakanishi Y, Bastow KF, Cragg G, Lee KH　PHYTOCHEMISTRY　67　894　2006/03
  • 　Cancer Preventive Agents 5. Antitumor-Promoting Effects of Coumarins and Related Compounds on Epstein-Barr Virus Action and Two-Stage Mouse Skin Carcinogenesis,　Suzuki M, Nakagawa-Goto K, Nakamura S, Tokuda H, Morris-Natschke SL, Kozuka M, Nishino H, Lee KH　PHARMACEUTICAL BIOLOGY　44　178　2006/02
  • 　Cancer Preventive Agents. Part 6: Chemopreventive Potential of Furanocoumarins and Related Compounds　Wang X, Nakagawa-Goto K, Kozuka M, Tokuda H, Nishino H, Lee KH, 　PHARMACEUTICAL BIOLOGY　44　116　2006/01
  • 　Total Synthesis and Bioactivity of Unique Flavone Desmosdumotin B and Its Analogs　Nakagawa-Goto K, Bastow KF, Wu JH, Lee KH　BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　15　3016　2005/04
  • 　First Total Synthesis of Desmosduotin C　Nakagawa-Goto K, Lee KH　SYNTHETIC COMMUNICATIONS　35　1735　2005/04
  • 　Antitumor Agent 243. Syntheses and Cytotoxicity of Desmosdumotin C Derivatives　Nakagawa-Goto K, Wu JH, Bastow KF, Wu CC, Lee KH　BIOORGANIC & MEDICINAL CHEMISTRY　13　2325　2005/01
  • 　Antitumor Agent 238. Anti-tubulin and in vitro Cytotoxic Effects of N-Substituted Allocolchicinoids 　Nakagawa-Goto K, Jung MK, Hamel E, Wu CC, Bastow KF, Brossi A, Lee KH　HETEROCYCLES　65　541　2005/01
  • 　Antitumor Agent 236. Synthesis of Water-soluble Colchicine Derivatives　Nakagawa-Goto K, Chen CX, Hamel E, Wu CC, Bastow KF, Brossi A, Lee KH　BIOORGANIC & MEDICINAL CHEMISTRY LETTERS　15　235　2005/01
  • 　Synthetic Study Directed Toward Novel Multi-Linked Heterocycles　Somei M, Yamada Y, Kitagawa K, Sugaya K, Tomita Y, Yamada F, Nakagawa K　HETEROCYCLES　45　3　435　1997/01
  • 　Simple Syntheses of Marine Alkaloid, ()-Chelonin A, and its Analogs　Somei M, Aoki N, Nagahama Y, Nakagawa K　HETEROCYCLES　41　1　5　1995/01
  • 　Lithiation of 3-Dimethylaminomethyl- and 3-Dimethylaminoethyl-1-methoxyindole Derivatives, Heterocycles, 39 (1), 31-34 (1994). 　Nakagawa K, Somei M　HETEROCYCLES　39　1　31　1994/01
  • 　Syntheses of ()-4-Amino-1,3,4,5-tetrahydrobenz[cd]indole-4-carboxylic Acid, ()-4-N,N-Dipropylamino-4-hydroxymethyl- and ()-4-Propyloxy-1,3,4,5-tetrahydrobenz[cd]indoles　Somei M, Aoki N, Nakagawa K　HETEROCYCLES　38　7　1479　1994/01
  • 　Syntheses of ()-Clavicipitic Acid and its Derivatives　Somei M, Hamamoto S, Nakagawa K, Yamada F, Ohta T　HETEROCYCLES　37　2　719　1994/01
  • 　A Simple Four Step Synthesis and Optical Resolution of 4-Nitro-1,3,4,5-tetrahydrobenz[cd]indole, and the Syntheses of 1-Hydroxy Derivatives of 4-Nitro and 4-Amino-1,3,4,5-tetrahydrobenz[cd]indoles　Nakagawa K, Somei M　34　12　2269　1992/01
  • 　Ergot Alkaloids: The First and Five Step Total Syntheses of (–)- and (+)-6,7-Secoagroclavine, and the Syntheses of (–)- and (+)-6-Nor-6-propyl-6, 7-secoagroclavines ((–)- and (+)-KSU 1415) 　Nakagawa K, Somei M　HETEROCYCLES　32　5　873　1991/01
  • 　The First Total Synthesis of () Chanoclavine-I Acid and an Alternative Total Synthesis of ()-Chanoclavine-I　Somei M, Mukaiyama H, Nomura Y, Nakagawa K　HETEROCYCLES　31　11　1919　1990/01
  • 　Dopamine Receptor Stimulating Effects of Chanoclavine Analogous, Tricyclic Ergot Alkaloids, in the Brain 　Watanabe H, Somei M, Sekihara S, Nakagawa K, Yamada F　JAPANESE JOURNAL OF PHARMACOLOGY　45　501　1987/01
  • 　Novel seco-phenanthroquinolizidine alkaloids from Indonesian Boehmeria virgata　Abdul Rahim,Yohei Saito,Katsunori Miyake,Masuo Goto,Kyoko Nakagawa-Goto　Phytochemistry Letters　45　132　2021/10

Conference Presentations

  • Steppingstone to drug discovery with handcrafted natural products (conference：The 37th Symposium of Natural Products)(2022/10/22)
  • Drug Discovery and Development based on Natural Products(conference：1st Makassar International Conference in Pharmaceutical Sciences)(2021/09/26)
  • Total Synthesis of Bioactive Diterpene, Parvifloron F(conference：254th ACS National Meeting & Exposition)(2017/08/20)
  • Drug discovery and development based on natural products(conference：Special Seminar in Hasanuddin University)(2017/07/10)
  • Drug discovery and development by chemical modification of natural products(2015/09/30)

show all

  • Benzothiophenyl flavones as new classes of mitotic inhibitors(conference：250th ACS National Meeting & Exposition)(2015/08/16)

Others

Arts and Fieldwork

Patent

○4-Amino-2H-pyran-2-one analogs as anticancer agents and their preparation (No： WO 2012061012 A2)
○Novel 4-amino-2H-benzo[h]chromen-2-one analogs as anti-cancer agents(No：No. 61/317,983)
○Desmosdumotins, their manufactures and use as antitumor and anti-aids agent. (No：WO2006069533)

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「ヌクレオチド除去修復機構解明に向けたケミカルアプローチ」(2019-2021)　
○「希少熱帯資源から新規創薬リードへの展開」(2018-2021)　
○「前立腺癌微小環境内での細胞間クロストークをターゲットとした革新的治療薬の開発」(2017-2019)　
○「インドネシア産自生植物および伝承薬の化学的保存」(2016-2019)　
○「新規DNA修復阻害剤を活用したメカニズム解析と癌治療への応用」(2016-2018)　
○「熱帯林植物からの新規抗がん剤候補薬の探索研究」(2013-2016)　
○「天然物由来小分子化合物を用いた多剤耐性がん選択性のケミカルバイオロジー」(2013-2015)　
○「ケミカルバイオロジーを利用したヒトヌクレオチド除去修復機構の解析 」(2013-2015)　
○「新規抗ガン性indolo[2,3-a]carbazole化合物群の合成研究 」(1994-)　
○「薬理活性1-ヒドロキシインドール化合物群の合成と反応 」(1993-)　
○「1-ヒドロキシインドール化学の展開と、循環器系疾患治療薬の開拓研究 」(1996-)　
○「薬理活性4位窒素置換benz[cd]indole化合物群の合成研究 」(1992-)　
○「薬理活性インド-ル化合物群の合成研究 」(1990-)　
○「2位に置換基を持つ新規な三環性麦角アルカロイド誘導体の合成研究 」(1990-)　
○「有機金属化合物を利用した環状化合物の新規クロスカップリング反応開拓研 」(1988-)　
○「ジデルペンによる前立腺癌進展制御機構の解明と新規化合物の開発」(2019-2021)　

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

○Laboratory Rotation 3(2019)
○Natural Products Chemistry(2019)
○Laboratory Rotation 1(2019)
○World of Chemistry(2019)
○Experiments in Organic Chemistry(2019)
○Experiments in Fundamental Chemistry(2019)
○Laboratory Rotation 1(2018)
○Laboratory Rotation 3(2018)
○Experiments in Organic Chemistry(2018)
○World of Chemistry(2018)
○Experiments in Fundamental Chemistry(2018)
○World of Chemistry(2017)
○Natural Products Chemistry(2017)
○Experiments in Organic Chemistry(2017)
○Experiments in Fundamental Chemistry(2017)
○Experiments in Organic Chemistry(2016)
○Experiments in Fundamental Chemistry(2016)
○Laboratory Rotation 2(2016)
○Science of Natural Products(2016)
○World of Chemistry(2016)

Classes (Graduate Schools)

○Introduction to Discovering Molecular Probes Ⅱ(2019)
○Advanced Course of Pharmachemistry(2019)
○Advanced Seminar on Pharmachemistry(2019)
○Advanced Course of Organic Chemistry(2019)
○Advanced Course of Pharmachemistry(2018)
○Introduction to Discovering Molecular Probes(2018)
○Applied Pharmacognosy(2018)
○Advanced Seminar on Pharmachemistry(2018)
○Advanced Course of Organic Chemistry(2018)
○Advanced Course of Organic Chemistry(2017)
○Advanced Seminar on Pharmachemistry(2017)
○Advanced Organic Chemistry III(2017)
○Advanced Pharmacognosy(2017)
○Advanced Course of Pharmachemistry(2017)
○Advanced Organic Chemistry IV(2017)
○Bioorganic Chemistry(2017)
○Applied Pharmacognosy(2016)
○Introduction to Pharmaceutical Sciences(2016)
○Advanced Pharmacognosy(2016)
○Advanced Pharmacognosy(2012)
○Applied Pharmacognosy(2012)

International Project

International Students

Lecture themes

Others (Social Activities)

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