last modified：2024/11/22
Professor MORISHITA Eriko
Faculty, Affiliation
Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences
College and School Educational Field
Division of Health Sciences, Graduate School of Medical Science
Division of Health Sciences，Graduate School of Medical Science
Department of Laboratory Sciences，School of Health Sciences, College of Medical, Pharmaceutical and Health Sciences
Laboratory
TEL:076-265-2606 FAX:
Academic Background
Career
Kanazawa University Graduate School of Medical Science
Kanazawa University
Boston University School of Medicine Department of Pathology and Laboratory Medicine Research professor(2016-)
Kanazawa University Institute of Medical, Pharmaceutical and Health Sciences Faculty of Health Sciences
Year & Month of Birth
Academic Society
The Japanese Society on Thrombosis and Hemostasis
Japan Thrombosis and Hemostasis
Japan Atherosclerosis Society
the Japanese Society of Hematology
Japanese Society of Laboratory Medicine
The Japanese Society of Clinical Hematology
The Japanese Society of Laboratory Medicine
Award
The Japanese Society of Laboratory Medicine
The Japanese Society of Laboratory Medicine
The Japanese Society of Laboratory Medicine
Specialities
Hematology、Laboratory medicine
Speciality Keywords
Hematology
Research Themes
Genetic analysis and expression studiesin congenital cogulation factor deficiencies and coagulation inhibitor deficiencies
I conduct genetic analysis of individuals with congenital coagulation factor deficiencies and coagulation inhibitor deficiencies, and their families, to identify the mutation sites. I have analyzed coagulation factor deficiencies in terms of prothrombin, factors VII, X, XI, XII, and prekallikrein, as well as coagulation inhibitor deficiencies in terms of protein C, protein S(PS), antithrombin, and have continuously demonstrated new mutation sites that had not been reported internationally. Further, I generate abnormal molecules with a recombinant DNA procedure and conduct their functional analysis. PS deficiency is important also as a cause of habitual abortion, and the demand for its genetic analysis will likely increase.
Mechanism of thrombosis in arteriovascular disease
With regard to arteriosclerosis and thrombosis, I examine hyperlipidemia and thrombotic tendency with molecular markers and manifestation of monocytic coagulation−fibrinolytic factors upon lipoprotein stimulus. Recently, I have been conducting research on the effect of an antihypercholesterolemia, HMG-CoA reductase inhibitor (statin), on coagulation−fibrinolytic system as a pleiotropic effect, and have clarified that statin down-regulate monocytic tissue factors in vascular endothelial cells and the manifestation of a coagulation−fibrinolytic factor PAI-1, while down-regulate the manifestation of anticaking factor TFPI, thereby demonstrating the potential for anti-thrombogenicity effect.
Mechanism of thormbotic formation in Hemolytic Uremic Syndrome
Crosstalk betwenn inflammation and thrombosis
Disseminated Intravascular Syndrome
antiphospholipid syndrome
Mechanism of thrombosis in arteriovascular disease
Congenital thrombophilia
Antithrobotic efests of hemeoxygenase-1
Books
- Asakura H, Takahashi Y, Kubo A, Ontachi Y, Hayashi T, Omote M, Arahata M, Kadohira Y, Maekawa M, Yamazaki M, Morishita E, Takami A, Yoshida T, Miyamoto K, Nakao S Immunoglobulin preparations attenuate organ dysfunction and hemostatic abnormality by suppressing the production of cytokines in lipopolysaccharide-induced disseminated intravascular coagulation in rats 34 9 2421-5 2006/09
- Asakura H, Asamura R, Ontachi Y, Hayashi T, Yamazaki M, Morishita E, Miyamoto KI, Nakao S Selective inducible nitric oxide synthase inhibition attenuates organ dysfunction and elevated endothelin levels in LPS-induced DIC model rats 3 5 1050-5 2005/05
- Ontachi Y, Morishita E, Nakao S, etc No interplay between the pathways mediating coagulation and inflammation in tissue factor-induced disseminated intravascular coagulation in rats 34 10 2646-2650 2006/10
- Recent Progress in Blood Coagulation and Fibrinolysis Elsevier 1998/01
Papers
- Relapse of acquired hemophilia A following COVID-19. Atsushi Marumo,Hisae Sugihara,Ikuko Omori,Eriko Morishita Journal of Nippon Medical School = Nippon Ika Daigaku zasshi 2023/02/21
- The length of the sanitary napkins can be used as a handier index than pictorial blood loss assessment chart to predict the heavy menstrual bleeding. Azusa Nagao,Tazuko Tokugawa,Yoko Matsuo,Rie Shirayama,Eriko Morishita,Masahiro Nozima,Ei Kinai,Yasuharu Nishida,Katsuyuki Fukutake The journal of obstetrics and gynaecology research 49 7 1838 2023/05/04
- Thrombosis-related characteristics of pregnant women with antithrombin deficiency, protein C deficiency and protein S deficiency in Japan Takao Kobayashi,Kazuko Sugiura,Toshiyuki Ojima,Mariko Serizawa,Kyuya Hirai,Eriko Morishita Thrombosis Journal 22 1 2024/12
- Functional analysis of two abnormal antithrombin proteins with different intracellular kinetics Yuta Imai,Satomi Nagaya,Yuhei Araiso,Makiko Meguro-Horike,Tomoki Togashi,Shin-ichi Horike,Hiroshi Kawasaki,Eriko Morishita Thrombosis Research 230 18 2023/10
- Factor V Leiden-independent activated protein C resistance: Communication from the plasma coagulation inhibitors subcommittee of the International Society on Thrombosis and Haemostasis Scientific and Standardisation Committee. Gary W Moore,Elisabetta Castoldi,Jun Teruya,Eriko Morishita,Dorothy M Adcock Journal of thrombosis and haemostasis : JTH 21 1 164 2023/01
- Identification and Prognostication of End-of-Life State Using a Japanese Guideline-Based Diagnostic Method: A Diagnostic Accuracy Study. Masahisa Arahata,Hidesaku Asakura,Eriko Morishita,Shinji Minami,Yukihiro Shimizu International journal of general medicine 16 23 2023
- Moving against thrombosis: ISTH recognizes 10th anniversary of World Thrombosis Day and the leaders in the field who led the way - in memory of Claire McLintock, MD, World Thrombosis Day Steering Committee Vice Chair 2019 to 2022. Louise St Germain,Erich De Paula,Cihan Ay,Stefano Barco,Gabriela Cesarman-Maus,Jean M Connors,Mert Dumantepe,Maria Cecilia Guillermo Esposito,Lai Heng Lee,Eriko Morishita,Charles Marc Samama,Helen Okoye,Todd Robertson,Gordon McPherson,Lana A Castellucci Journal of thrombosis and haemostasis : JTH 21 9 2311 2023/09
- Protein S deficiency caused by cryptic splicing due to the novel intron variant c.346+5G>C in PROS1 Satomi Nagaya,Tomoki Togashi,Masaharu Akiyama,Yuta Imai,Haruto Matsumoto,Haruka Moriya,Makiko Meguro-Horike,Ibuki Yasuda,Yuika Kikuchi,Yamato Kuwajima,Shin-ichi Horike,Atsushi Watanabe,Eriko Morishita Thrombosis Research 229 26 2023/06
- Time of Day of Vaccination Does Not Associate With SARS–CoV–2 Antibody Titer Following First Dose of mRNA COVID–19 Vaccine Yujiro Yamanaka,Isao Yokota,Atsushi Yasumoto,Eriko Morishita,Hisanori Horiuchi Journal of Biological Rhythms 37 6 700 2022/09/26
- Diagnostic and treatment guidelines for thrombotic thrombocytopenic purpura (TTP) in Japan 2023. Masanori Matsumoto,Yoshitaka Miyakawa,Koichi Kokame,Yasunori Ueda,Hideo Wada,Satoshi Higasa,Hideo Yagi,Yoshiyuki Ogawa,Kazuya Sakai,Toshiyuki Miyata,Eriko Morishita,Yoshihiro Fujimura International journal of hematology 2023/09/10
- Identification of two de novo variants causing inherited antithrombin deficiency by quantitative analysis of variant alleles Tomoki Togashi,Satomi Nagaya,Makiko Meguro-Horike,Haruto Matsumoto,Yuta Imai,Koichi Yamaguchi,Yoshinari Fujii,Haruka Moriya,Yuika Kikuchi,Ibuki Yasuda,Shin-ichi Horike,Eriko Morishita Thrombosis Research 2023/11
- A case of venous thromboembolism caused by protein C deficiency due to a novel gene mutation Jun-ichi Noiri,Hiroki Matsuzoe,Satomi Nagaya,Ryo Nishio,Daisuke Matsumoto,Hiroshi Takaishi,Eriko Morishita Journal of Cardiology Cases 26 5 360 2022/11
- COVID-19 and Thrombosis: Clinical Aspects. Tetsumei Urano,Atsushi Yasumoto,Kenji Yokoyama,Hisanori Horiuchi,Eriko Morishita,Yuko Suzuki Current drug targets 23 17 1567 2022/10/05
- Identification and functional analysis of three novel genetic variants resulting in premature termination codons in three unrelated patients with hereditary antithrombin deficiency Yuta Imai,Satomi Nagaya,Yuhei Araiso,Makiko Meguro-Horike,Tomoki Togashi,Kensho Ohmori,Yuka Makita,Eiichi Sato,Toshiaki Yujiri,Yuta Nagamori,Shin-ichi Horike,Atsushi Watanabe,Eriko Morishita International Journal of Hematology 117 4 523 2022/12/16
- Effect of Anticoagulant/Antifibrinolytic Combination Therapy on Enhanced Fibrinolytic-Type Disseminated Intravascular Coagulation in End-of-Life Stage Solid Tumor Patients. Shinya Yamada,Yukio Suga,Eriko Morishita,Hidesaku Asakura Journal of palliative medicine 26 2 307 2022/09/14
- Determination of diagnostic threshold in harmonization and comparison of clinical utility for five major antiphospholipid antibody assays used in Japan. Risa Kaneshige,Yukari Motoki,Mika Yoshida,Kenji Oku,Eriko Morishita,Masahiro Ieko,Kiyoshi Ichihara,Junzo Nojima Journal of clinical laboratory analysis 36 5 e24340 2022/05
- First report of inherited protein S deficiency caused by paternal PROS1 mosaicism. Satomi Nagaya,Keiko Maruyama,Atsushi Watanabe,Makiko Meguro-Horike,Yuta Imai,Yuki Hiroshima,Shin-Ichi Horike,Koichi Kokame,Eriko Morishita Haematologica 107 1 330 2022/01/01
- A call to action: MTHFR polymorphisms should not be a part of inherited thrombophilia testing. Thomas G Deloughery,Beverley J Hunt,Geoffrey D Barnes,Jean M Connors,WTD Steering Committee. Research and practice in thrombosis and haemostasis 6 4 e12739 2022/05
- Recombinant human erythropoietin attenuates hepatic dysfunction by suppressing hepatocellular apoptosis in lipopolysaccharide-induced disseminated intravascular coagulation in rats. Yukio Suga,Fumio Akita,Shinya Yamada,Eriko Morishita,Hidesaku Asakura Biomedical reports 16 1 5 2022/01
- Effect on Plasma Protein S Activity in Patients Receiving the Factor Xa Inhibitors. Takako Terakami,Satomi Nagaya,Kenshi Hayashi,Hiroshi Furusho,Noboru Fujino,Takeshi Kato,Hidesaku Asakura,Eriko Morishita Journal of atherosclerosis and thrombosis 29 7 1059 2021/07/30
- [Thrombosis with Thrombocytopenia Syndrome after ChAdOx1 nCoV-19 vaccination]. Mari Takatsuki,Toshihiko Araki,Akira Kanno,Atsushi Yasumoto,Eriko Morishita,Hiroshi Shiota Rinsho shinkeigaku = Clinical neurology 62 6 487 2022/06/24
- Autoimmune Acquired Factor XIII/13 Deficiency after SARS-CoV-2 mRNA Vaccination. Shingen Nakamura,Motoki Sugasaki,Masayoshi Souri,Hirohito Akazawa,Maiko Sogawa,Taiki Hori,Hiroki Yamagami,Makoto Takishita,Ken-Ichi Aihara,Masahiro Abe,Atsushi Yasumoto,Eriko Morishita,Akitada Ichinose Thrombosis and haemostasis 122 10 1837 2022/07/30
- Peripartum management of hereditary thrombophilia: results of primary surveillance in Japan. Takao Kobayashi,Kazuko Sugiura,Toshiyuki Ojima,Kyuya Hirai,Eriko Morishita International journal of hematology 116 3 364 2022/09
- [COVID-19-associated coagulopathy]. Eriko Morishita [Rinsho ketsueki] The Japanese journal of clinical hematology 62 8 1236 2021
- Ilio-femoral venous thrombosis with hereditary antithrombin deficiency: a case report of rare thrombotic disease and successful treatment with catheter directed thrombolysis. Hirokazu Miyashita,Kazuki Tobita,Eriko Morishita,Shigeru Saito European heart journal. Case reports 5 2 ytaa531 2021/02
- Recurrent Cerebral Venous Thrombosis Treated with Direct Oral Anticoagulants in a Japanese Man with Hereditary Protein C Deficiency. Kazuyuki Saito,Kazuyuki Ishii,Konosuke Furuta,Masaki Kobayashi,Yoshiaki Wada,Eriko Morishita Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 30 1 105320 2021/01
- A Case of Treatment With Dabigatran for Cerebral Venous Thrombosis Caused by Hereditary Protein C Deficiency. Taiki Fukushima,Yoshimitsu Shimomura,Satomi Nagaya,Eriko Morishita,Osamu Kawakami Cureus 13 6 e15473 2021/06
- Donor UNC-93 Homolog B1 genetic polymorphism predicts survival outcomes after unrelated bone marrow transplantation. Kaori Uchino,Lam Vu Quang,Shohei Mizuno,Tomohiro Horio,Hidesuke Yamamoto,Ichiro Hanamura,Yoshihisa Kodera,J Luis Espinoza,Makoto Onizuka,Koichi Kashiwase,Yasuo Morishima,Takahiro Fukuda,Noriko Doki,Koichi Miyamura,Takehiko Mori,Eriko Morishita,Shinji Nakao,Akiyoshi Takami Genes and immunity 22 1 35 2021/05
- The Japanese Medical Science Federation COVID-19 Expert Opinion English Version. Masaomi Nangaku,Takashi Kadowaki,Hiroshi Yotsuyanagi,Norio Ohmagari,Moritoki Egi,Junichi Sasaki,Tetsuya Sakamoto,Yoshinori Hasegawa,Takashi Ogura,Shigeru Chiba,Koichi Node,Ryo Suzuki,Yasuhiro Yamaguchi,Atsuko Murashima,Norihiko Ikeda,Eriko Morishita,Kenji Yuzawa,Hiroyuki Moriuchi,Satoshi Hayakawa,Daisuke Nishi,Atsushi Irisawa,Toshiaki Miyamoto,Hidetaka Suzuki,Hirohito Sone,Yuuji Fujino JMA journal 4 2 148 2021/04/15
- Comparative evaluation of reagents for measuring protein S activity: possibility of harmonization. Masahiro Ieko,Taeko Hotta,Kumiko Watanabe,Tomoko Adachi,Sawako Takeuchi,Sumiyoshi Naito,Mika Yoshida,Kazumasa Ohmura,Nobuhiko Takahashi,Eriko Morishita,Hiroko Tsuda,Dongchon Kang International journal of hematology 113 4 530 2021/04
- COVID-19-Related Thrombosis in Japan: Final Report of a Questionnaire-Based Survey in 2020. Hisanori Horiuchi,Eriko Morishita,Tetsumei Urano,Kenji Yokoyama Journal of atherosclerosis and thrombosis 28 4 406 2021/04/01
- Effect of NOS Inhibitors and Anticoagulants on Nitric Oxide Production in a Tissue-factor Induced Rat DIC Model Yukio Suga,Yoko Takahashi,Tsutomu Shimada,Shinya Yamada,Eriko Morishita,Hidesaku Asakura IN VIVO 35 4 1999 2021/07
- Blue Rubber Bleb Nevus Syndrome Complicated by Enhanced-Fibrinolytic-Type DIC: A Case Report. Shinya Yamada,Masahisa Arahata,Eriko Morishita,Hidesaku Asakura Annals of vascular diseases 14 3 252 2021/09/25
- Clinical guidance for peripartum management of patients with hereditary thrombophilia. Takao Kobayashi,Eriko Morishita,Hiroko Tsuda,Reiko Neki,Tetsuhito Kojima,Shouichi Ohga,Masayuki Ochiai,Tomoko Adachi,Toshiyuki Miyata The journal of obstetrics and gynaecology research 47 9 3008 2021/09
- Protein C Gene Mutation in an Older Adult Patient with Clostridium perfringens Septicemia-Related Visceral Vein Thrombosis. Kiyoko Kanosue,Satomi Nagaya,Eriko Morishita,Masayoshi Yamanishi,Shinsaku Imashuku TH open : companion journal to thrombosis and haemostasis 5 2 e171-e173 2021/04
- Evaluation of Optimal Sample Processing Conditions for Accurate Measurement of Protein S Activity. Satomi Nagaya,Yuhei Araiso,Koichi Yamaguchi,Yuichiro Omote,Asaka Matsui,Hidesaku Asakura,Eriko Morishita Annals of clinical and laboratory science 51 2 206 2021/03
- Natural killer cell function changes by the Japanese Kampo Medicine Juzentaihoto in General fatigue patients: an open label study Keiko Ogawa-Ochiai,Takamasa Katagiri,Yuki Sato,Akiko Shirai,Ken Ishiyama,Akiyoshi Takami,Eriko Morishita ADVANCES IN INTEGRATIVE MEDICINE 8 1 33 2021/03
- Detailed exploration of pathophysiology involving inflammatory status and bleeding symptoms between lipopolysaccharide- and tissue factor-induced disseminated intravascular coagulation in rats. Yukio Suga,Anna Kubo,Hideyuki Katsura,Yukiko Staub,Kiyomichi Tashiro,Shinya Yamada,Eriko Morishita,Hidesaku Asakura International journal of hematology 114 2 172 2021/08
- Potential of continuous tPA infusion for multiple-organ failure from lipopolysaccharide-induced disseminated intravascular coagulation in rats. Yukio Suga,Kiyomichi Tashiro,Yukiko Staub,Shiori Komura,Shinya Yamada,Eriko Morishita,Hidesaku Asakura Thrombosis research 206 84 2021/08/19
- Coagulation and fibrinolytic features in AL amyloidosis with abnormal bleeding and usefulness of tranexamic acid. Masahisa Arahata,Hiroyuki Takamatsu,Eriko Morishita,Yasuko Kadohira,Shinya Yamada,Akitada Ichinose,Hidesaku Asakura International journal of hematology 111 4 550 2020/04
- Complete hemostasis achieved by factor XIII concentrate administration in a patient with bleeding after teeth extraction as a complication of aplastic anemia and chronic disseminated intravascular coagulation. Shinya Yamada,Hirokazu Okumura,Eriko Morishita,Hidesaku Asakura Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 31 4 274 2020/06
- 直接経口抗凝固薬が血中プロテインC活性測定値に与える影響(The effect of direct oral anticoagulants on blood protein C activity) 寺上 貴子,關谷 暁子,林 研至,鈴木 健史,古荘 浩司,朝倉 英策,森下 英理子,和田 隆志 Journal of Wellness and Health Care 44 1 33 2020/08
- Donor Heme Oxygenase-1 Promoter Gene Polymorphism Predicts Survival after Unrelated Bone Marrow Transplantation for High-Risk Patients. Tomohiro Horio,Eriko Morishita,Shohei Mizuno,Kaori Uchino,Ichiro Hanamura,J Luis Espinoza,Yasuo Morishima,Yoshihisa Kodera,Makoto Onizuka,Koichi Kashiwase,Takahiro Fukuda,Noriko Doki,Koichi Miyamura,Takehiko Mori,Shinji Nakao,Akiyoshi Takami Cancers 12 2 2020/02/12
- Molecular genetic analysis of inherited protein C deficiency caused by the novel large deletion across two exons of PROC. Tomoki Togashi,Makiko Meguro-Horike,Satomi Nagaya,Sayaka Sugihara,Tatsuo Ichinohe,Yuhei Araiso,Koichi Yamaguchi,Kotaro Mori,Yuta Imai,Kana Kuzasa,Shin-Ichi Horike,Hidesaku Asakura,Atsushi Watanabe,Eriko Morishita Thrombosis research 188 115 2020/04
- Racial differences in protein S Tokushima and two protein C variants as genetic risk factors for venous thromboembolism. Hiroko Tsuda,Kenta Noguchi,Doyeun Oh,Zsuzsanna Bereczky,Lai H Lee,Dongchon Kang,Luci M S Dusse,Maria das G Carvalho,Eriko Morishita Research and practice in thrombosis and haemostasis 4 8 1295 2020/11
- Aortic Mural Thrombus Associated with Congenital Protein C Deficiency in an Elderly Patient. Kazuki Ueda,Eriko Morishita,Hironaga Shiraki,Shunzo Matsuoka,Shinsaku Imashuku Journal of atherosclerosis and thrombosis 27 1 100 2020/01/01
- A Case of Ischemic Stroke With Congenital Protein C Deficiency and Carotid Web Successfully Treated by Anticoagulant and Carotid Stenting. Sadayoshi Watanabe,Shoji Matsumoto,Ichiro Nakahara,Akira Ishii,Taketo Hatano,Minako Mori,Eriko Morishita,Izumi Nagata Frontiers in neurology 11 99 2020
- Genetic analysis of a compound heterozygous patient with congenital factor X deficiency and regular replacement therapy with a prothrombin complex concentrate. Tomoki Togashi,Satomi Nagaya,Masayuki Nagasawa,Makiko Meguro-Horike,Keiji Nogami,Yuta Imai,Kana Kuzasa,Akiko Sekiya,Shin-Ichi Horike,Hidesaku Asakura,Eriko Morishita International journal of hematology 111 1 51 2020/01
- Potential therapeutics for antiphospholipid antibody associated thrombocytopenia: A systematic review and meta-analysis. Nobuya Abe,Kenji Oku,Olga Amengual,Yuichiro Fujieda,Masaru Kato,Toshiyuki Bohgaki,Shinsuke Yasuda,Rintaro Mori,Eriko Morishita,Katsue Suzuki-Inoue,Tatsuya Atsumi Modern rheumatology 30 1 116 2020/01
- Hereditary Antithrombin Deficiency Presenting with Deep Venous Thrombosis During the Second Pregnancy. Motoki Yamashita,Tomo Komaki,Kohei Tashiro,Yuki Inada,Atsushi Iwata,Masahiro Ogawa,Eriko Morishita,Shin-Ichiro Miura Internal medicine (Tokyo, Japan) 59 2 235 2020/01/15
- Recipient ADAMTS13 Single-Nucleotide Polymorphism Predicts Relapse after Unrelated Bone Marrow Transplantation for Hematologic Malignancy. Haruka Nomoto,Akiyoshi Takami,J Luis Espinoza,Makoto Onizuka,Koichi Kashiwase,Yasuo Morishima,Takahiro Fukuda,Yoshihisa Kodera,Noriko Doki,Koichi Miyamura,Takehiko Mori,Shinji Nakao,Eriko Morishita International journal of molecular sciences 20 1 2019/01/08
- Portal Vein Thrombosis in a Patient with Hereditary Antithrombin Deficiency. Tamao Setaka,Katsuharu Hirano,Keiichi Moriya,Tougen Kaneko,Seie Morita,Tetsu Shinkai,Eriko Morishita,Takafumi Ichida Internal medicine (Tokyo, Japan) 58 12 1733 2019/06/15
- The first reported case of acquired haemophilia A in which bleeding episodes were successfully treated via administration of a single-dose mixture of activated factor VIIa/X. Shinya Yamada,Masahisa Arahata,Eriko Morishita,Akitada Ichinose,Hidesaku Asakura Haemophilia : the official journal of the World Federation of Hemophilia 25 5 e350-e352 2019/09
- A case of recurrent cerebral vein thrombosis with protein C gene mutation identified Yumeho Sugahara,Natsuki Ono,Eriko Morishita,Hiroshi Takashima Rinsho Shinkeigaku 58 12 764 2018
- Gene analysis of inherited antithrombin deficiency and functional analysis of abnormal antithrombin protein (N87D). Sayaka Kamijima,Akiko Sekiya,Mao Takata,Haruka Nakano,Morika Murakami,Tomonori Nakazato,Hidesaku Asakura,Eriko Morishita International journal of hematology 107 4 490 2018/04
- A discrepancy between prothrombin time and Normotest (Hepaplastintest) results is useful for diagnosis of acquired factor V inhibitors. Yasuko Kadohira,Shinya Yamada,Tomoe Hayashi,Eriko Morishita,Hidesaku Asakura,Akitada Ichinose International journal of hematology 108 2 145 2018/08
- Congenital coagulation factor X deficiency: Genetic analysis of five patients and functional characterization of mutant factor X proteins. Satomi Nagaya,Masashi Akiyama,Morika Murakami,Akiko Sekiya,Hidesaku Asakura,Eriko Morishita Haemophilia : the official journal of the World Federation of Hemophilia 24 5 774 2018/09
- The first genome-wide association study identifying new susceptibility loci for obstetric antiphospholipid syndrome Mayumi Sugiura-Ogasawara,Yosuke Omae,Minae Kawashima,Licht Toyo-Oka,Seik-Soon Khor,Hiromi Sawai,Tetsuya Horita,Tatsuya Atsumi,Atsuko Murashima,Daisuke Fujita,Tomio Fujita,Shinji Morimoto,Eriko Morishita,Shinji Katsuragi,Tamao Kitaori,Kinue Katano,Yasuhiko Ozaki,Katsushi Tokunaga Journal of Human Genetics 62 9 831 2017/09
- Aortic Aneurysm-associated Disseminated Intravascular Coagulation that Responded Well to a Switch from Warfarin to Rivaroxaban Yasuko Kadohira,Shinya Yamada,Erika Matsuura,Tomoe Hayashi,Eriko Morishita,Shinji Nakao,Hidesaku Asakura Internal Medicine 56 21 2913 2017
- Causative genetic mutations for antithrombin deficiency and their clinical background among Japanese patients Akiko Sekiya,Fumina Taniguchi,Daisuke Yamaguchi,Sayaka Kamijima,Shonosuke Kaneko,Shiori Katsu,Miho Hanamura,Mao Takata,Haruka Nakano,Hidesaku Asakura,Shigeki Ohtake,Eriko Morishita INTERNATIONAL JOURNAL OF HEMATOLOGY 105 3 287 2017/03
- Thrombosis Prediction Based on Reference Ranges of Coagulation-Related Markers in Different Stages of Pregnancy Akiko Sekiya,Tomoe Hayashi,Yasuko Kadohira,Masami Shibayama,Tomohide Tsuda,Xiuri Jin,Haruka Nomoto,Hidesaku Asakura,Takashi Wada,Shigeki Ohtake,Eriko Morishita CLINICAL AND APPLIED THROMBOSIS-HEMOSTASIS 23 7 844 2017/10
- Gene analysis of six cases of congenital protein S deficiency and functional analysis of protein S mutations (A139V, C449F, R451Q, C475F, A525V and D599TfsTer13) Fumina Taniguchi,Eriko Morishita,Akiko Sekiya,Haruka Nomoto,Shiori Katsu,Shounosuke Kaneko,Hidesaku Asakura,Shigeki Ohtake THROMBOSIS RESEARCH 151 8 2017/03
- Factor XI deficiency as a result of a novel Tyr347Stop nonsense mutation in an elderly Japanese woman Jun Ando,Azuchi Masuda,Kazuhide Iizuka,Tomonori Ochiai,Naoki Shingai,Hajime Yasuda,Yasuhiro Homma,Erina Kobayashi,Eriko Morishita,Norio Komatsu Geriatrics & Gerontology International 17 6 1029 2017/06
- Diagnosis and treatment of inherited thrombophilia. Eriko Morishita [Rinsho ketsueki] The Japanese journal of clinical hematology 58 7 866 2017
- A case of aortic aneurysm-associated DIC that responded well to a switch from warfarin to rivaroxaban. Kadohira Y, Matsuura E, Hayashi T, Morishita E, Nakao S, Asakura H. Int Med. 56 21 2913-2917 2017/11/01
- Familial discrepancy of clinical outcomes associated with fibrinogen Dorfen: A case of huge genital hematoma after episiotomy Kyosuke Kagami,Rena Yamazaki,Tetsuya Minami,Nobuo Okumura,Eriko Morishita,Hiroshi Fujiwara JOURNAL OF OBSTETRICS AND GYNAECOLOGY RESEARCH 42 6 722 2016/06
- Pregnancy outcomes of patients with paroxysmal nocturnal hemoglobinuria treated with eculizumab: a Japanese experience and updated review Naoyuki Miyasaka,Osamu Miura,Tatsuya Kawaguchi,Nobuyoshi Arima,Eriko Morishita,Kensuke Usuki,Yasuyoshi Morita,Kaichi Nishiwaki,Haruhiko Ninomiya,Akihiko Gotoh,Shinsaku Imashuku,Akio Urabe,Tsutomu Shichishima,Jun-ichi Nishimura,Yuzuru Kanakura INTERNATIONAL JOURNAL OF HEMATOLOGY 103 6 703 2016/06
- Asymptomatic Dysprothrombinemia (Prothtombin Himi) with p.M380T and p.R431H Shows Severely Reduced Clotting Activity, Moderate Antithrombin Resistance and Severe Thrombomodulin Binding Defect Eriko Morishita,Mao Takata,Fumina Taniguchi,Masashi Akiyama,Akiko Sekiya,Akira Takagi,Toshiyuki Miyata,Tetsuhito Kojima BLOOD 128 22 2016/12
- Thrombosis prediction based on reference ranges of coagulation-related markers in different stages of pregnancy. Clinical and Applied Clinical and Applied Thrombosis/Hemostasis DOI: 10.1177. 2016
- Fulminant bilateral cerebral infarction caused by paradoxical embolism in a patient with protein S Ala525Val substitution Yoji Yoshikawa,Jiro Kitayama,Hiromi Ishikawa,Asako Nakamura,Fumina Taniguchi,Eriko Morishita,Tetsuro Ago,Hiroshi Nakane,Takanari Kitazono NEUROLOGY AND CLINICAL NEUROSCIENCE 3 3 105 2015/05
- A donor thrombomodulin gene variation predicts graft-versus-host disease development and mortality after bone marrow transplantation. Nomoto H,Takami A,Espinoza JL,Matsuo K,Mizuno S,Onizuka M,Kashiwase K,Morishima Y,Fukuda T,Kodera Y,Doki N,Miyamura K,Mori T,Nakao S,Ohtake S,Morishita E International journal of hematology 102 4 460 2015/08
- Rivaroxaban in a Patient With Disseminated Intravascular Coagulation Associated With an Aortic Aneurysm: A Case Report Tomoe Hayashi,Noriharu Nakagawa,Yasuko Kadohira,Eriko Morishita,Hidesaku Asakura ANNALS OF INTERNAL MEDICINE 161 2 158 2014/07
- ELISA-Based Detection System for Protein S K196E Mutation, a Genetic Risk Factor for Venous Thromboembolism. Maruyama K,Akiyama M,Kokame K,Sekiya A,Morishita E,Miyata T PloS one 10 7 e0133196 2015
- Late onset thrombosis in two Japanese patients with compound heterozygote protein S deficiency. Taniguchi F,Morishita E,Sekiya A,Yamaguchi D,Nomoto H,Kobayashi E,Takata M,Kosugi I,Takeuchi N,Asakura H,Ohtake S Thrombosis research 135 6 1221 2015/06
- Erratum to: A donor thrombomodulin gene variation predicts graft-versus-host disease development and mortality after bone marrow transplantation. Haruka Nomoto,Akiyoshi Takami,J Luis Espinoza,Keitaro Matsuo,Shohei Mizuno,Makoto Onizuka,Koichi Kashiwase,Yasuo Morishima,Takahiro Fukuda,Yoshihisa Kodera,Noriko Doki,Koichi Miyamura,Takehiko Mori,Shinji Nakao,Shigeki Ohtake,Eriko Morishita International journal of hematology 102 4 507 2015/10
- Thrombomodulin Has a Significant Impact on Transplant Outcomes after HLA-Fully-Matched Unrelated Bone Marrow Transplantation for Standard Risk Hematologic Malignancies Nomoto Haruka,Morishita Eriko,Takami Akiyoshi,Katsu Shiori,Yamaguchi Daisuke,Morishima Yasuo,Onizuka Makoto,Kashiwase Koichi,Fukuda Takahiro,Kodera Yoshihisa,Nakao Shinji,Ohtake Shigeki BLOOD 124 21 2014/12/06
- Fluvastatin upregulates the expression of tissue factor pathway inhibitor in human umbilical vein endothelial cells. Sekiya A,Morishita E,Maruyama K,Torishima H,Ohtake S J Atheroscler Thromb. 22 7 660 2015
- Fulminant bilateral cerebral infarction caused by paradoxical embolism in a patient with protein S Ala525Val substitution Yoshikawa Y, Kitayama J, Ishikawa H, Nakamura A, Taniguchi F, Morishita E, Ago T, Nakane H, Kitazono Neurology and Clinical Neuroscience 2015/01/09
- Causative genetic mutations for antithrombin deficiency and their clinical background among Japanese patients Int J Hematol 2016
- Carbon Monoxide-Releasing Molecule-Derived CO Regulates Tissue Factor, Plasminogen Activator Inhibitor Type 1, and Thrombomodulin Production by Human Endothelial Cells Keiko Maruyama,Eriko Morishita,Shigeki Ohtake,Akihiro Yachie,Shinji Nakao BLOOD 116 21 495 2010/11
- Expression of annexin II in experimental abdominal aortic aneurysms. Hayashi T,Morishita E,Ohtake H,Oda Y,Asakura H,Nakao S International journal of hematology 90 3 336 2009/10
- Curcumin Prevents Cytokine-Mediated Tissue Factor Pathway Inhibitor Down-Regulation in Human Endothelial Cells Keiko Maruyama,Eriko Morishita,Yukie Goto,Akiko Sekiya,Hidesaku Asakura,Shigeki Ohtake,Shinji Nakao BLOOD 118 21 541 2011/11
- Management Of Pregnancy In Paroxysmal Nocturnal Hemoglobinuria (PNH): A Report Of 10 Cases From The Working Group On Pregnancy Of The Japan PNH Study Group Kensuke Usuki,Akio Urabe,Tatsuya Kawaguchi,Naoyuki Miyasaka,Osamu Miura,Eriko Morishita,Nobuyoshi Arima,Yasuyoshi Morita,Kaichi Nishiwaki,Haruhiko Ninomiya,Akihiko Gotoh,Shinsaku Imashuku,Tsutomu Shichishima,Jun-ichi Nishimura,Yuzuru Kanakura BLOOD 122 21 2013/11
- Curcumin Down-Regulates Cytokine-Mediated Tissue Factor and Plasminogen Activator Type 1 Expression In Human Endothelial Cells Morishita Eriko,Maruyama Keiko,Asakura Hidesaku,Ohtake Shigeki,Yachie Akihiro,Nakao Shinji BLOOD 116 21 1365 2010/11/19
- A Genetic Variation in the Heme Oxygenase-1 Gene Predicts the Outcome of HLA-Fully-Matched Unrelated Bone Marrow Transplantation Morishita Eriko,Maruyama Keiko,Takami Akiyoshi,Onizuka Makoto,Kawase Takakazu,Morishima Yasuo,Fukuda Takahiro,Kodera Yoshihisa,Ohtake Shigeki,Yachie Akihiro,Nakao Shinji BLOOD 118 21 862 2011/11/18
- The Association of a Single Nucleotide Polymorphism in the Chemokine CXCL10 Gene with Transplant Outcomes After HLA-Matched Unrelated Bone Marrow Transplantation for Low Risk Hematologic Malignancies Nakata Katsuya,Espinoza Luis J,Onizuka Makoto,Fukuda Takahiro,Kawase Takakazu,Morishita Eriko,Kodera Yoshihisa,Morishima Yasuo,Ohtake Shigeki,Nakao Shinji,Takami Akiyoshi BLOOD 118 21 899 2011/11/18
- A single nucleotide polymorphism of Granzyme B gene in the recipient predicts relapse after HLA matched unrelated bone marrow transplantation for standard-risk haematologic malignancies Takami A,Espinoza J. L,Nakata K,Morishita E,Ohtake S,Fukuda T,Morishima Y,Kodera Y,Nakao S BONE MARROW TRANSPLANTATION 46 1 S169 2011
- Prophylactic administration of prothrombin complex concentrates for congenital prothrombin deficiency with a novel frameshift mutation, prothrombin saitama Seki, Masafumi; Koh, Katsuyoshi; Inoue, Takeshi; Tomita, Yuzo; Kato, Motohiro; Shimizu, Masaki; Morishita, Eriko; Hanada, Ryoji Pediatric Blood and Cancer 60 3 503-505 2013/03/01
- Plasma levels of platelet-derived microparticles are increased after anaerobic exercise in healthy subjects Maruyama, Keiko; Kadono, Tadaaki; Morishita, Eriko Journal of Atherosclerosis and Thrombosis 19 6 585-587 2012/07/11
- Hemostatic management of surgery for imperforate anus in a patient with 13q deletion syndrome with combined deficiency of factors VII and X. Kurosawa H, Suzumura H, Okuya M, Fukushima K, Sugita K, Fujiwara T, Morishita E, Yoshioka A, Takamiya O, Arisaka O 15(1) 398-400 2009/01
- Expression of annexin II in human atherosclerotic abdominal aortic aneurysms. Hayashi T, Morishita E, Ohtake H, Oda Y, Ohta K, Arahata M, Kadohira Y, Maekawa M, Ontachi Y, Yamazaki M, Asakura H, Takami A, Nakao S THROMBOSIS RESEARCH 123(2) 274-80 2009/03
- Changes in molecular markers of hemostatic and fibrinolytic activation under various sampling conditions using vacuum tube samples from healthy volunteers. Omote M, Asakura H, Takamichi S, Shibayama M, Yoshida T, Kadohira Y, Maekawa M, Yamazaki M, Morishita E, Nakao S, Wada T 123(2) 390-5 2008/02
- A case of factor X (FX) deficiency due to novel mutation V196M, FX Hofu. 1) Shinohara K, Adachi M, Matsui K, Matsuda K, Nagaya S, Morishita E INTERNATIONAL JOURNAL OF HEMATOLOGY 87 3 256-259 2008/03
- Effects of combined therapy of danaparoid sodium and tranexamic acid on chronic disseminated intravascular coagulation associated with abdominal aortic aneurysm Ontachi Y, Asakura H, Morishita E, et al Circulation Journal 69 9 1150-1153 2005/09
- Increased macrophage colony-stimulating factor levels in patients with Graves' disease. Morishita E, Sekiya A, Hayashi T, Kadohira Y, Maekawa M, Yamazaki M, Asakura H, Nakao S, Ohtake S INTERNATIONAL JOURNAL OF HEMATOLOGY 88(3) 272-7 2008/03
- Effects of sarpogrelate hydrochloride in a patient with chronic graft-versus-host disease: a case report. Hayashi T, Morishita E, Ontachi Y, Yamazaki M, Asakura H, Yoshida T, Nakao S AMERICAN JOURNAL OF HEMATOLOGY 81 2 121-123 2006/02
- Atorvastatin reduces plasma levels of factor VII activity and factor VII antigen in patients with hyperlipidemia 9 1 72-78 2002/01
- Significant of decreased plasma D-Dimer levels following lipoplysaccharide-induced disseminated intravascular coagulation in rats Asakura H, Sano Y, Omote M, Yoshida T, Ontachi Y, Mizutani T, Kaneda M, Yamazaki M, Morishita E, et al INTERNATIONAL JOURNAL OF HEMATOLOGY 79 394-9 2004
- Antithrombotic role of nitric oxide in rats under physiological conditions Asakura H, Okudaira M, Ontachi Y, Mizutani T, Omote M, Yoshida T, Kaneda M, Yamazaki M, Morishita E, et al THROMBOSIS AND HAEMOSTASIS 91 71-5 2004
- Role of fibrinolysis in tissue-factor-induced disseminated intravascular coagulation in rats - an effect of tranexamic acid Asakura H, Sano Y, Yamazaki M, Morishita E, et al HAEMATOLOGICA 89 6 757-8 2004/06
- Beneficial effect of low-molecular-weight heparin against lipopolysaccharide-induced disseminated intravascular coagulation in rats is abolished by coadministrastion of tranexamic acid Asakura H, Sano Y, Yoshida T, Omote M, Ontachi Y, Mizutani T, Yamazaki M, Morishita E, et al INTENSIVE CARE MEDICINE 30 1950-1955 2004
- An idiopathic skin eruption resembling a butterfly rash in a septic patient with disseminated intravascular coagulation following bone marrow transplantation Ontachi Y, Asakura H, Funada H, Takami A, Saito M, Morishita E, etal BLOOD COAGULATION & FIBRINOLYSIS 15 3 255-259 2004/03
- Marked difference in pathophysiology between tissue factor-and lipopolysaccharide-induced disseminated intravascular coagulation models in rats. CRITICAL CARE MEDICINE 30 1 161-164 2002/11
- Elevated plasma levels of free-form of TFPI in hypercholesterolemic patients. ATHEROSCLEROSIS 154 1 203-212 2001/01
- An enhanced fibrinolysis prevents the development of multiple organ failure in DIC in spite of much activation of blood coagulation. CRITICAL CARE MEDICINE 29 6 1164-1168 2001/06
- Elevated levels of free tissue factor pathway inhibitor antigen in cases of disseminated intravascular coagulation caused by various underlying diseases. BLOOD COAGULATION & FIBRINOLYSIS 12 1 1-8 2001/01
- Depressed plasma activity of antithrombin or protein C is not due to consumption coagulopathy in septic patients with DIC. EUROPEAN JOURNAL OF HAEMATOLOGY 67 170-175 2001/06
- All-trans retinoic acid is partially effective against lipopolysaccharide-induced but not against tissue-factor-induced DIC in rat models. BLOOD COAGULATION & FIBRINOLYSIS 12 4 301-306 2001/06
- Vitamin K administration to elderly patients with osteoporosis induces no hemostatic activation, even in those with suspected vitamin K deficiency. OSTEOPOROSIS INTERNATIONAL 12 996-1000 2001/12
- One missence mutation in the factor X gene causing factor X deficiency (factor X Kanazawa) INTERNATIONAL JOURNAL OF HEMATOLOGY 73 3 390-392 2001/04
- Beneficial effect of the active form of vitamin D3 against LPS-induced DIC but not against tissue-factor-induced DIC in rat models. THROMBOSIS AND HAEMOSTASIS 85 287-290 2001/02
- Depressed plasma activity of plasminogen or a2-plasmin inhibitor is not due to consumption coagulopathy in septic patients with DIC. Blood Coagulation and Fibrinolysis 12 4 275-281 2001/06
- Hypercoagulability and hypofibrinolysis in subjects with hyperlipoproteinemia T Matsuda,E Morishita,M Yamazaki,H Jokaji,H Asakura,M Saito DRUGS AFFECTING LIPID METABOLISM 10 219 1996
- Protective effects of DX-9065a, an orally active, novel synthesized and selective inhibitor of factor Xa, against thromboplastin-induced experimental disseminated intravascular coagulation in rats M Yamazaki,H Asakura,K Aoshima,M Saito,H Jokaji,C Uotani,Kumabashiri, I,E Morishita,T Ikeda,T Matsuda SEMINARS IN THROMBOSIS AND HEMOSTASIS 22 3 255 1996
- Mechanism on disorders of coagulation and fibrinolysis in diabetes T Matsuda,E Morishita,H Jokaji,H Asakura,M Saito,T Yoshida,K Takemoto DIABETES 45 S109 1996/07
- Hypercoagulability and high lipoprotein(a) levels in patients with type II diabetes mellitus E Morishita,H Asakura,H Jokaji,M Saito,C Uotani,Kumabashiri, I,M Yamazaki,K Aoshima,T Hashimoto,T Matsuda ATHEROSCLEROSIS 120 1-2 7 1996/02
- Hypercoagulability and high lipoprotein(a) levels in patients with aplastic anemia receiving cyclosporine E Morishita,S Nakao,H Asakura,H Jokaji,M Saito,C Uotani,Kumabashiri, I,M Yamazaki,T Yoshida,K Takemoto,K Aoshima,T Hashimoto,T Matsuda BLOOD COAGULATION & FIBRINOLYSIS 7 6 609 1996/09
- Prednisolone inhibits endotoxin-induced disseminated intravascular coagulation and improves mortality in rats: importance of inflammatory cytokine suppression. BLOOD COAGULATION & FIBRINOLYSIS 10 6 321-330 1999/09
- Short-term effects of fluvastatin, a HMG-CoA reductase inhibitor, on coagulation and the fibrinolytic system in patientswith hypercholesterolemia. INTERNATIONAL JOURNAL OF HEMATOLOGY 69 4 274-276 1999/06
- Prothrombin Himi; an abnormal prothrombin characterized by a defective thrombin activity. Morishita E,Saito M,Asakura H,Jokaji H,Uotani C,Kumabashiri I,Yamazaki M,Hachiya H,Okamura M,Matsuda T Thrombosis research 62 6 697 1991/06
- Study of the balance between coagulation and fibrinolysis in disseminated intravascular coagulation using molecular markers. Asakura H,Jokaji H,Saito M,Uotani C,Kumabashiri I,Morishita E,Yamazaki M,Aoshima K,Matsuda T Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 5 5 829 1994/10
- CHANGES IN PLASMA-LEVELS OF PROTHROMBIN FRAGMENT-F1+2 IN CASES OF DISSEMINATED INTRAVASCULAR COAGULATION H ASAKURA,Y SHIRATORI,H JOKAJI,M SAITO,C UOTANI,KUMABASHIRI, I,E MORISHITA,M YAMAZAKI,T MATSUDA ACTA HAEMATOLOGICA 89 1 22 1993
- Changes in plasma levels of tissue-plasminogen activator/inhibitor complex and active plasminogen activator inhibitor in patients with disseminated intravascular coagulation. Asakura H,Jokaji H,Saito M,Uotani C,Kumabashiri I,Morishita E,Yamazaki M,Matsuda T American journal of hematology 36 3 176 1991/03
- Plasma levels of lipoprotein(a) are elevated in patients with the antiphospholipid antibody syndrome. Yamazaki M,Asakura H,Jokaji H,Saito M,Uotani C,Kumabashiri I,Morishita E,Aoshima K,Ikeda T,Matsuda T Thrombosis and haemostasis 71 4 424 1994/04
- PLASMINOGEN-ACTIVATOR INHIBITOR IN PLASMA AND ARTERIOSCLEROSIS T MATSUDA,E MORISHITA,H JOKAJI,M SAITO,KUMABASHIRI, I,H AKAKURA,C UOTANI,M YAMAZAKI ATHEROSCLEROSIS III: RECENT ADVANCES IN ATHEROSCLEROSIS RESEARCH 748 394 1995
- Effects of DX-9065a, an orally active, newly synthesized and specific inhibitor of factor Xa, against experimental disseminated intravascular coagulation in rats. Yamazaki M,Asakura H,Aoshima K,Saito M,Jokaji H,Uotani C,Kumabashiri I,Morishita E,Ikeda T,Matsuda T Thrombosis and haemostasis 72 3 392 1994/09
- Hyperlipidemia and Hemostatic System Eriko Morishita,Hiroshi Jokaji,Tamotsu Matsuda Journal of Atherosclerosis and Thrombosis 2 1995
- ROLE OF ENDOTHELIN IN DISSEMINATED INTRAVASCULAR COAGULATION H ASAKURA,H JOKAJI,M SAITO,C UOTANI,KUMABASHIRI, I,E MORISHITA,M YAMAZAKI,T MATSUDA AMERICAN JOURNAL OF HEMATOLOGY 41 2 71 1992/10
- The course of disseminated intravascular coagulation is predicted by changes in thrombin-antithrombin III complex levels--is there any difference between treatment with standard heparin or low-molecular-weight heparin? Asakura H,Jokaji H,Saito M,Uotani C,Kumabashiri I,Morishita E,Yamazaki M,Matsuda T Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 2 5 623 1991/10
- Haemostatic and fibrinolytic parameters in septic patients with leukopenia or leukocytosis. Saito M,Asakura H,Jokaji H,Uotani C,Kumabashiri I,Morishita E,Yamazaki M,Yoshida T,Aoshima K,Matsuda T European journal of haematology 54 3 176 1995/03
- Plasma levels of soluble thrombomodulin increase in cases of disseminated intravascular coagulation with organ failure. Asakura H,Jokaji H,Saito M,Uotani C,Kumabashiri I,Morishita E,Yamazaki M,Matsuda T American journal of hematology 38 4 281 1991/12
- Levels of activated factor VII in patients with disseminated intravascular coagulation. Saito M,Asakura H,Yoshida T,Jokaji H,Uotani C,Kumabashiri I,Morishita E,Yamazaki M,Aoshima K,Matsuda T Blood 85 12 3770 1995/06
- PROTHROMBIN HIMI - A COMPOUND HETEROZYGOTE FOR 2 DYSFUNCTIONAL PROTHROMBIN MOLECULES (MET-337-]THR AND ARG-388-]HIS) E MORISHITA,M SAITO,KUMABASHIRI, I,H ASAKURA,T MATSUDA,K YAMAGUCHI BLOOD 80 9 2275 1992/11
- 2 GENETIC-DEFECTS IN A PATIENT WITH COMPLETE DEFICIENCY OF THE B-SUBUNIT FOR COAGULATION FACTOR-XIII T HASHIGUCHI,M SAITO,E MORISHITA,T MATSUDA,A ICHINOSE BLOOD 82 1 145 1993/07
- Recombinant hirudin for the treatment of disseminated intravascular coagulation in patients with haematological malignancy. Saito M,Asakura H,Jokaji H,Uotani C,Kumabashiri I,Morishita E,Yamazaki M,Aoshima K,Matsuda T Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 6 1 60 1995/02
- [Leukemia and pre-DIC--coagulation and fibrinolytic parameters in severe infection at the nadir of leukocyte after chemotherapy]. Saito M,Asakura H,Jokaji H,Uotani C,Kumabashiri I,Morishita E,Yamazaki M,Matsuda T Rinsho byori. The Japanese journal of clinical pathology Suppl 86 July 158 1990/07
- [Tissue-type plasminogen activator and its inhibitor (PAI-1) in plasma in cases of non-insulin-dependent diabetes mellitus (NIDDM)]. Jokaji H,Asakura H,Saito M,Uotani C,Kumabashiri I,Morishita E,Yamazaki M,Matsuda T Nihon Ronen Igakkai zasshi. Japanese journal of geriatrics 27 6 699 1990/11
- Relationship between elevation in the plasma concentration of elastase-alpha 1 proteinase inhibitor complex (E-alpha 1 PI) and haemostatic parameters during haemodialysis. Yamazaki M,Asakura H,Saito M,Jokaji H,Uotani C,Kumabashiri I,Morishita E,Aoshima K,Sato T,Tsugawa Y Blood coagulation & fibrinolysis : an international journal in haemostasis and thrombosis 6 1 5 1995/02
- INCREASED LEVELS OF PLASMA THROMBOMODULIN IN CHRONIC MYELOGENOUS LEUKEMIA E MORISHITA,M SAITO,H ASAKURA,H JOKAJI,C UOTANI,KUMABASHIRI, I,M YAMAZAKI,T MATSUDA AMERICAN JOURNAL OF HEMATOLOGY 39 3 183 1992/03
- USEFULNESS OF MOLECULAR MARKERS IN THE DIAGNOSIS OF THE PRETHROMBOTIC STATE H ASAKURA,M SAITO,H JOKAJI,C UOTANI,KUMABASHIRI, I,E MORISHITA,M YAMAZAKI,T MATSUDA ACTA HAEMATOLOGICA JAPONICA 53 8 1649 1990/12
- Role of tissue factor in disseminated intravascular coagulation. Asakura H,Kamikubo Y,Goto A,Shiratori Y,Yamazaki M,Jokaji H,Saito M,Uotani C,Kumabashiri I,Morishita E Thrombosis research 80 3 217 1995/11
- Disseminated intravascular coagulation (DIG); Etiology, frequency, diagnosis and treatment in Japan T Matsuda,H Asakura,M Saito,M Yamazaki,E Morishita,K Aoshima RECENT PROGRESS IN BLOOD COAGULATION AND FIBRINOLYSIS 1129 229 1997
- Platelet and large platelet ratios are useful in predicting severity of COVID-19. Hisae Sugihara,Atsushi Marumo,Haruka Okabe,Kiyotaka Kohama,Takashi Mera,Eriko Morishita International journal of hematology 2024/03/23
- Computational analyses reveal fundamental properties of the AT structure related to thrombosis. Tiago J S Lopes,Ricardo A Rios,Tatiane N Rios,Brenno M Alencar,Marcos V Ferreira,Eriko Morishita Bioinformatics advances 3 1 vbac098 2023
Conference Presentations
- Molecular basis and thrombotic manifestations of antithrombin deficiency in Japanese patients(conference：Scientific and Standardization Committee Symposium, International Society on Thrombosis and Haemostasis)
- COVID-19-associated coagulopathy(conference：Cardiovascular and Metabolic Week 2020)
- Impact of direct oral anticoagulants on Protein S total activity assay －New method to test protein S－(conference：International Society on Thrombosis and Haemostasis 2019)(2019/07/19)
- COVID-19-Related Thrombosis in Japan: Results of a Questionnaire-based Survey in 2020(conference：International Society on Thrombosis and Haemostasis 2021)(2021/07/17)
- Adeno-associated virus vector-mediated gene therapy for congenital protein C deficiency in mice(conference：第83回日本血液学会学術集会)(2021/09/23)
- Updates on using recombinant thrombomodulin for disseminated intravascular coagulation. SSC Session (Plasma coagulation inhibitor)(conference：International Society on Thrombosis and Haemostasis 2021)(2021/07/17)
- COVID-19-associated coagulopahty(conference：The 19th International Symposium on Atherosclerosis)(2021/10/25)
- Molecular characterization of a novel splicing mutation of the PROS1 gene causing inherited protein S deficiency.(2022/10/09)
- Measurement of platelet microparticles CLEC2 using flow cytometry(conference：International Society for Laboratory Hematology 2022.)(2022/09/08)
- Effects of sample processing on antithrombin and protein C activity(conference：International Society for Laboratory Hematology 2022)(2022/09/09)
- A machine learning framework identifies properties of the antithrombin protein leading to thrombosis.(2022/10/15)
- Investigation of changes in neutrophil cells surface markers over time. The 17th Congress of Asian Society of Clinical Pathology and Laboratory Medicine (ASCPaLM)(2022/10/09)
- Gene therapy for protein C deficiency by ectopic expression of an engineered protein C in mice(2022/10/15)
- A Case of Venous Thromboembolism Caused by Protein C deficiency due to a Novel Genetic Mutation(2022/03/11)
- コンピューター解析によって解明された血栓形成傾向に重要なプロテインC構造特性(conference：日本血液学会学術集会)(2022/10)
- The potential of PS cleavage to regulate anticoagulant function in septic DIC. The 17th Congress of Asian Society of Clinical Pathology and Laboratory Medicine (ASCPaLM)(2022/10/09)
- 遺伝性の出血障害をもつ日本人女性と女児における経血の負荷と絵入りの血液評価チャートの有用性(The burden of menstrual bleeding and use of the pictorial blood assessment chart in Japanese women and girls with inherited bleeding disorders: a validation study)(conference：東京医科大学雑誌)(2022/10)
- Pathophysiological analysis of thrombophilia in hemodialysis patients. The 17th Congress of Asian Society of Clinical Pathology and Laboratory Medicine (ASCPaLM)(2022/10/09)
- mRNAワクチン単回投与後の遺伝子変異と抗SARS-Cov2抗体について(conference：日本血液学会学術集会)(2022/10)
- 電撃性紫斑病を契機に診断した先天性プロテインS欠乏症の一例(conference：日本血液学会学術集会)(2022/10)
- COVID-19-associated coagulopahty(2021/03/13)
- 十全大補湯によるＮＫ細胞機能増強効果の検討(conference：第57回日本臨床検査医学会東海・北陸支部総会、第336回日本臨床化学会東海・北陸支部例会)(2018/03/11)
- ヘパリンからDOACへの変更に伴い治療効果が著変下血管腫に伴う慢性ＤＩＣの一例(conference：第18回ＴＴＭフォーラム)(2018/03/03)
- 直接経口抗凝固薬が血中アンチトロンビン、プロテインC、プロテインS活性測定値に与える影響(conference：第79回日本血液学会学術集会)(2017/10/20)
- 十全大補湯によるNK細胞機能増強効果の検討(conference：第42回北陸臨床病理集談会)(2017/09/02)
- ヒト iPS 細胞由来造血幹細胞を用いた6pLOH マウスモデルの作製(conference：第42回北陸臨床病理集談会)(2017/09/02)
- 先天性プロテインＣ欠損症の遺伝子解析および異常プロテインＣ蛋白(K437E)の機能解析(conference：第42回北陸臨床病理集談会)(2017/09/02)
- EliAによる自動分析装置を用いた抗リン脂質抗体価測定の有用性(conference：第18回日本検査血液学会学術集会)(2017/07/22)
- 当院で経験した第V因子インヒビター4例の特徴.(conference：第39回日本血栓止血学会学術集会)(2017/06/08)
- Possible therapeutics for antiphospholipid antibody related thrombocytopenia：A systemic review and meta-analysis(conference：The American College of Rheumatology/Association of Rheumatology Health Professionals 2017 annual meeting.)(2017/11/03)
- 静脈血栓塞栓症の成因と治療―悪性腫瘍を中心にー(conference：Cancer VTE Seminar in Yokohama)(2018/03/01)
- 静脈血栓塞栓症の成因と治療(conference：第五回抗凝固療法セミナー)(2018/02/26)
- 知っておきたい静脈血栓塞栓症の傾向と対策(conference：血栓塞栓症を考える会)(2017/04/06)
- 静脈血栓塞栓症の病態・診断・治療～悪性腫瘍および先天性血栓性素因を中心に～(conference：iMET in KOBE)(2017/06/22)
- APTT延長を認めたらどんな病態を考えますか？(conference：45nd SEKISUI Coagulation Seminar in Ariake)(2017/07/01)
- 静脈血栓塞栓症の病態・診断・治療～悪性腫瘍および先天性血栓性素因を中心に～(conference：東葛HEART研究会)(2017/11/14)
- 悪性腫瘍に関連する血栓症(conference：第17回群馬血栓止血研究会)(2017/11/16)
- 静脈血栓塞栓症の病態・診断・治療～悪性腫瘍および先天性血栓性素因を中心に～(conference：VTE BOARD FORUM 2017)(2017/12/04)
- 播種性血管内凝固症候群（DIC)と輸血(conference：愛知県臨床検査技師輸血研究班講演会)(2017/12/09)
- 先天性血栓性素因の病態と解釈～臨床検査技師の視点から～(conference：第18回日本検査血液学会学術集会)(2017/07/22)
- 先天性第Ｘ因子欠乏症5症例のphenotypeおよびgenotype(conference：第12回日本血栓止血学会学術標準化委員会（SSC）)(2018/02/10)
- 部会活動の紹介ならびに指定難病「特発性血栓症」の診断に際しての問題点(conference：第12回日本血栓止血学会学術標準化委員会（SSC）)(2018/02/10)
- 血液の難病に挑む～出血と血栓に関連する血液難病について～(conference：厚生労働科学研究費補助金難治性疾患政策研究事業 血液凝固異常症等に関する研究班)(2018/02/03)
- Development of ELISA system for detection of Protein S K196E mutation, a genetic risk factor for venous thromboembolism.(conference：ISTH)(2015/06/20)
- Thrombomodulin has a significant impact on transplant outcomes after HLA-fully-matched unrelated bone marrow transplantation for standard risk hematologic malignancies(conference：56th American Society of Hematoogy Annual Meeting)(2014/12/05)
- An uncommon case of deep venous thrombosis and pulmonary thromboembolism in a juvenile with compound heterozygous congenital protein S deficiency(conference：XXVI World Congress of the International Union of Angiology)(2014/08/10)
- A genetic variant in the CD53 intron functiononally predicts transplant outcomes after HLA-matched unrelated bone marrow transplantation(conference：第18回欧州血液学会(EHA))(2013/06/13)
- Management of pregnancy in paroxysmal nocturnal hemoglobinuria(conference：55rd ASH Annual Meeting)(2013/12/07)
Others
Arts and Fieldwork
Patent
Theme to the desired joint research
Grant-in-Aid for Scientific Research
○「血液凝固異常症等に関する調査研究班」(2023-2025)
○「遺伝性血栓症の病因（オミックス解析）と病態の解明」(2022-2024)
○「血液凝固異常症等に関する調査研究班」(2020-2022)
○「ヘムオキシゲナーゼー１が造血幹細胞移植後治療成績におよぼす効果と新規治療戦略」(2018-2020)
○「身近に感じる血液のしくみを一緒に体験してみよう」(2018-2018)
○「血液凝固異常症等に関する調査研究班」(2017-2019)
○「ヘムオキシゲナ－ゼ－１と同種造血幹細胞移植後転帰の関連性および新規治療戦略」(2015-2018)
○「抗リン脂質抗体関連血小板減少症の病態解明と治療指針の構築に関する研究」(2015-2016)
○「生体侵襲時におけるヘムオキシゲナーゼ1を介する血栓形成制御機構の解明」(2006-2008)
○「身近に感じる血液のしくみを一緒に体験してみよう」(2015-)
○「身近に感じる血液のしくみを一緒に体験してみよう」(2014-)
○「ヘムオキシゲナーゼー1が造血幹細胞移植治療成績におよぼす改善効果の解明と新規治療戦略」(2015-)
○「ヘムオキシゲナーゼー1が造血幹細胞移植後治療成績におよぼす効果と新規治療戦略」(2015-2017)
○「血液凝固異常症等に関する調査研究班」（主任研究者 村田満）」(2014-2016)
○「「生体侵襲時におけるヘムオキシゲナーゼ１と同種造血幹細胞移植後転帰の関連性および新規治療戦略」」
○「ヘムオキシゲナ－ゼ－１と同種造血幹細胞移植後転帰の関連性および新規治療戦略」(2012-2014)
○「ヘムオキシゲナ-ゼ-1と同種造血幹細胞移植後転帰の関連性および新規治療戦略」(2012-2014)
○「ヒムオキシゲナーゼ-1(HO-1)が凝固・線容系因子の発現調節に果たす役割の解明」(2007-2009)
○「生体侵襲時におけるヘムオキシゲナーゼ-1を介する血栓形成制御機構の解明」(2009-2011)
○「生体侵襲時におけるヘムオキシゲナーゼ1を介する血栓形成制御機構の解明」(2007-)
○「白血病における白血球インテグリンＭａｃ-1を介する線容機序」(2001-)
○「白血病における白血病インテグリンMac-1を介する線溶機序」(2000-)
○「インテグリンMac-1を介する白血病細胞表面の凝固開始機構」(1998-)
○「インテグリンMac-1を介する白血病細胞表面の凝固開始機構」(1997-)
Competitive research funding,Contribution
Collaborative research,Consignment study
Classes (Bachelors)
○Immunology(2023)
○Clinial Practice of Hematology and Blood Transfusion(2023)
○Hematology(2023)
○Immunology(2023)
○Laboratory Medicine of Blood Transfusion(2023)
○Clinial Practice of Hematology and Blood Transfusion(2023)
○Hematology(2023)
○Practice in Laboratory Hematology(2023)
○Pathophysiology 1(2023)
○Presentation and Debate(2023)
○Pathophysiology 1(2023)
○Practice in Laboratory Hematology(2023)
○Academic Skill(2023)
○Introduction to Region-studies(2023)
○Immunology(2022)
○Laboratory Hematology(2022)
○Clinial Practice of Hematology and Blood Transfusion(2022)
○Laboratory Hematology(2022)
○Laboratory Medicine of Blood Transfusion(2022)
○Clinial Practice of Hematology and Blood Transfusion(2022)
○Immunology(2022)
○Hematology(2022)
○Pathophysiology 1(2022)
○Practice in Laboratory Hematology(2022)
○Hematology(2022)
○Pathophysiology 1(2022)
○Practice in Laboratory Hematology(2022)
Classes (Graduate Schools)
○Laboratory Oncology: Seminar(2023)
○Advanced Laboratory Oncology: Research(2023)
○Advanced Laboratory Oncology: Research(2023)
○Advanced Laboratory Oncology: Research(2023)
○Advanced Laboratory Oncology: Research(2023)
○Laboratory Oncology: Seminar(2023)
○Laboratory Oncology: Seminar(2023)
○Advanced Laboratory Oncology: Research(2023)
○Advanced Laboratory Oncology: Research(2023)
○Advanced Laboratory Oncology: Research(2023)
○Advanced Laboratory Oncology: Research(2023)
○Laboratory Oncology: Seminar(2023)
○Advanced Laboratory Oncology: Research(2023)
○Advanced Laboratory Oncology: Research(2023)
○Advanced Laboratory Oncology: Research(2023)
○Advanced Laboratory Oncology: Research(2023)
○Laboratory Oncology: Lecture(2023)
○Advanced Laboratory Oncology: Research(2023)
○Laboratory Oncology: Lecture(2023)
○Advanced Laboratory Oncology: Research(2023)
○Advanced Laboratory Oncology: Research(2023)
○Laboratory Oncology: Lecture(2023)
○Advanced Laboratory Oncology: Research(2023)
○Laboratory Oncology: Lecture(2023)
○Advanced Laboratory Oncology: Research(2023)
○Advanced Laboratory Oncology: Research(2023)
○Laboratory Rotation I(2023)
○Laboratory Oncology: Research(2023)
○Clinical Immunohematology: Seminar(2023)
○Clinical Immunohematology: Seminar(2023)
○Laboratory Oncology: Research(2023)
○Laboratory Oncology: Research(2023)
○Laboratory Oncology: Research(2023)
○Laboratory Oncology: Research(2023)
○Laboratory Oncology: Research(2023)
○Laboratory Oncology: Research(2023)
○Clinical Immunohematology: Seminar(2023)
○Laboratory Oncology: Research(2023)
○Laboratory Oncology: Research(2023)
○Laboratory Oncology: Research(2023)
○Laboratory Oncology: Research(2023)
○Clinical Immunohematology: Seminar(2023)
○Laboratory Oncology: Research(2023)
○Laboratory Rotation Ⅱ(2023)
○Laboratory Rotation Ｉ(2023)
○Laboratory Oncology: Research(2023)
○Laboratory Oncology: Research(2023)
○Laboratory Oncology: Research(2023)
○Laboratory Oncology: Research(2023)
○Clinical Immunohematology: Lecture(2023)
○Clinical Immunohematology: Lecture(2023)
○An Introduction to Medical Laboratory Sciences:Lec(2023)
○An Introduction to Medical Laboratory Sciences:Lec(2023)
○Laboratory Rotation Ⅱ(2023)
○Laboratory Rotation Ｉ(2023)
○Laboratory Oncology: Research(2023)
○Laboratory Oncology: Research(2023)
○Laboratory Oncology: Research(2023)
○Clinical Immunohematology: Lecture(2023)
○Clinical Immunohematology: Lecture(2023)
○Laboratory Oncology: Research(2023)
○Laboratory RotationⅠ(2023)
○Laboratory RotationⅠ(2023)
○Laboratory RotationⅠ(2023)
○Laboratory Rotation I(2023)
○Laboratory Rotation I(2023)
○An Introduction to Medical Laboratory Sciences:Lec(2019)
International Project
International Students
Lecture themes
Others (Social Activities)
○石川県医師会(2018-2018)