Professor WONG, Richard W.
Faculty, Affiliation
WPI Nano Life Science Institute
College and School Educational Field
Division of Natural Sciences, Graduate School of Natural Science and Technology
Division of Natural System, Graduate School of Natural Science and Technology
Course in Biosystems, School of Biological Science and Technology, College of Science and Engineering
Laboratory
Academic Background
【Degree】
Doctor of Medicine
Career
Associate Prof. FSO, Kanazawa University(2008/04-2012/03)
金沢大学 理工学域自然システム学類 Professor(2012/04-2018/03)
DIvision Head and Professor, MCB division, Bio-AFM center(2015/04-2018/03)
Institute for Frontier Science Initiative Unit leader and Professor(2015/04-)
WPI-NanoLSI(2017/10-)
Year & Month of Birth
Academic Society
The American Society for Cell Biology
The Royal Society of Medicine, United Kingdom
Protein Science Society of Japan
The Japanese Association of Anatomists (JAA)
JSCB
Award
Specialities
Speciality Keywords
nucleoporin, NPC, Cell cycle, mitotic spindles, kinesin, nuclear pore, SRM, HS-AFM
Research Themes
Nucleoporins structures and functions
We study RNA and protein transport through Nuclear Pore Complex (NPC) (also termed nucleoporins or nups) to ER . Many developmental defects and tumors are directly associated with alterations in nucleo-cytoplasmic transport, and my lab is interested in understanding how the NPC mediates transport and in gaining a better understanding of the molecular mechanisms of these defects. Meanwhile, we are also investigating the association of NPC proteins with the mitotic spindle during cell division.
Books
Papers
- Targeting Nucleoporin POM121-Importin β Axis in Prostate Cancer. Lim KS, Wong RW. Cell Chem Biol. 25 9 1056-1058 2018/09/20
- Colorectal cancer cells require glycogen synthase kinase-3β for sustaining mitosis via translocated promoter region (TPR)-dynein interaction Dewi FRP, Domoto T, Hazawa M, Kobayashi A, Douwaki T, Minamoto T and Wong RW (Correspondence) Oncotarget 9 13337-13352. 2018/01/30
- Rock-dependent phosphorylation of NUP62 regulates p63 nuclear transport and cell fate of squamous cell carcinoma Hazawa M, Lin D, Kobayashi A, Jiang YY, Dewi FRP, Mohamed MS, Hartono H, Nakada S, Meguro-Horike M, Horike S, Koeffler H and Wong RW EMBO rep 19 1 73-88 2018/01/15
- High-Speed Atomic Force Microscopy Reveals Loss of Nuclear Pore Resilience as a Dying Code in Colorectal Cancer Cells. Mohamed MS, Kobayashi A, Taoka A, Watanabe-Nakayama T, Kikuchi Y, Hazawa M, Minamoto T, Fukumori Y, Kodera N, Uchihashi T, Ando T, Wong RW 11 6 5567-5578 2017/06/17
- ZNF750 is a lineage-specific tumor suppressor in squamous cell carcinoma. Hazawa M, Lin D, Handral H, Xu L, Chen Y, Jiang YY, Thippeswamy A, Ding LW, Meng X, Sharma A, Samuel S, Movahednia M, Wong RW, Yang H, Tong C, and Koeffler H Oncogene doi: 10.1038/onc.2016.377. 36(16): 2243-2254. 2017/04/20
Conference Presentations
- Identifying nanoscopic spider cobweb features of native nuclear pores in cancer cells. (conference：International Symposium on Atomic Force Microscopy at Solid-Liquid Interfaces)(2017/11/08)
- ROCK-dependent phosphorylation of NUP62 regulates p63 nuclear transport in squamous cell carcinoma(conference：The 2017 ASCB | EMBO Meeting)(2017/12/04)
- Loss of Nuclear Pore Selective Barrier Revealed by High-Speed Atomic Force Microscopy in Colorectal Cancer Cells (2017/09/20)
Others
Arts and Fieldwork
Patent
Theme to the desired joint research
Grant-in-Aid for Scientific Research
Competitive research funding,Contribution
Collaborative research,Consignment study
Classes (Bachelors)
○Physiology 2(2017)
○Recombinant Dna Technology Lab(2017)
○Research Work in Biology(1)(2017)
○Research Seminar in Biology (1)(2017)
○Research Seminar in Biology (2)(2017)
○Research Work in Biology(2)(2017)
○Research Work in Biology(2)(2016)
○Physiology 2(2016)
○Research Work in Biology(1)(2016)
○Research Seminar in Biology (1)(2016)
○Research Seminar in Biology (2)(2016)
○Recombinant Dna Technology Lab(2016)
○Recombinant Dna Technology Lab(2016)
Classes (Graduate Schools)
○Molecular and Cellular Biology(2017)
○Integrated Systems Biology A(2017)
○Molecular and Cellular Biology(2017)
○Molecular and Cellular Biology(2017)
○Molecular and Cellular Biology(2017)
○Integrated Systems Biology B(2017)
○Integrated Systems Biology B(2016)
○Integrated Systems Biology A(2016)
○Molecular and Cellular Biology(2016)