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Researcher Information

last modified：2024/01/08

Professor　HIRAO Atsushi

Mail

Faculty, Affiliation

WPI Nano Life Science Institute

College and School Educational Field

Division of Medical Sciences, Graduate School of Medical Science
Division of Natural Sciences, Graduate School of Natural Science and Technology
Division of Medicine, Graduate School of Medical Science
Division of Natural System, Graduate School of Natural Science and Technology
Course in Biosystems, School of Biological Science and Technology, College of Science and Engineering

Laboratory

Division of Molecular Genetics　TEL:076-264-6755　FAX:076-234-4508

Academic Background

【Academic background(Bachelor's Degree)】
Jichi Medical School　School of Medicine　198803

Career

(2001/08/16-2002/03/31)
(2002/04/01-2004/10/31)
(2004/11/01-2005/03/31)
(1997/06/03-2001/08/15)
The University of Tokushima(1988/06/01-)
Japan Society for the Promotion of Science(1995/04/01-1998/03/31)

Year & Month of Birth

1963/10

Academic Society


The Japanese Society of Hematology

Award


○JSPS PRIZE(2008/03/03)
○JSPS PRIZE(2008/03/03)

Specialities

stem cell self-renewal、hematopoietic stem cell、Hematology、Experimental pathology

Speciality Keywords

stem cell self-renewal hematopoietic stem cell

Research Themes

molecular mechanisms for self-renewal of stem cells

Maintenace mechanisms for genomic stability

Books

  • 　Miyamoto K, Araki YK, Naka K, Arai F, Takubo K, Yamazaki S, Matsuoka S, Miyamoto T, Ito K, Ohmura M, Chen C, Hosokawa K, Nakauchi H, Nakayama K, Nakayama KI, Harada M, Motoyama N, Suda T, and Hirao A.　Foxo3a is essential for maintenance of the hematopoietic stem cell pool.　1　1　101-112　2007/06
  • 　Ito K, Takubo K, Arai F, Satoh H, Matsuoka S, Ohmura M, Naka K, Azuma M, Miyamoto K, Hosokawa K, Ikeda Y, Mak TW, Suda T, Hirao A　Regulation of reactive oxygen species by atm is essential for proper response to DNA double-strand breaks in lymphocytes.　178　1　103-10　2007/01
  • 　Ohtani N, Imamura Y, Yamakoshi K, Hirota F, Nakayama R, Kubo Y, Ishimaru N, Takahashi A, Hirao A, Shimizu T, Mann DJ, Saya H, Hayashi Y, Arase S, Matsumoto M, Kazuki N, Hara E.　Visualizing the dynamics of p21Waf1/Cip1 cyclin-dependent kinase inhibitor expression in living animals　104　38　15034-9　2007/08
  • 　Iwanaga A, Sato T, Sugihara K, Hirao A, Takakura N, Okamoto H, Asano M, Yoshioka K　Neural-specific ablation of the scaffold protein JSAP1 in mice causes neonatal death.　429　1　43-8　2007/11
  • 　Ito K, Hirao A, Arai F, Takubo K, Matsuoka S, Miyamoto K, Ohmura M, Naka K, Hosokawa K, Ikeda Y, Suda T　Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells　12　4　446-51　2006/04

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  • 　Takubo K, Hirao A, Ohmura M, Azuma M, Arai F, Nagamatsu G, Suda T.　Premeiotic germ cell defect in seminiferous tubules of Atm-null testis　351　4　993-8　2006/12
  • 　Azuma M, Hirao A, Takubo K, Hamaguchi I, Kitamura T, Suda T.　A quantitative matrigel assay for assessing repopulating capacity of prostate stem cells.　338　2　1164-70　2005/12
  • 　McPherson JP, Lemmers B, Hirao A, Hakem A, Abraham J, Migon E, Matysiak-Zablocki E, Tamblyn L, Sanchez-Sweatman O, Khokha R, Squire J, Hande MP, Mak TW, Hakem R　Collaboration of Brca1 and Chk2 in tumorigenesis　18　10　1144-53　2004/05
  • 　Identification of stem cells during prepubertal spermatogenesis via monitoring of nucleostemin promoter activity.　12　2008
  • 　Identification of tumor-initiating cells in a highly　in press　2009/09
  • 　Stem cell defects in ATM-deficient undifferentiated spermatogonia through DNA damage-induced cell cycle arrest.　2　170-182　2008
  • 　Activated macrophages promote Wnt signalling through tumour necrosis factor-alpha in gastric tumour cells.　27　1671-81　2008
  • 　Real-time in vivo imaging of p16Ink4a reveals cross talk with p53.　186(3)　393-407　2009

Papers

  • 　mTORC1 is essential for leukemia propagation but not stem cell self-renewal. 　122　2114-29　2012/06
  • 　NKX2.2 suppresses self-renewal of glioma-initiating cells.　Muraguchi T, Tanaka S, Yamada D, Tamase A, Nakada M, Nakamura H, Hoshii T, Ooshio T, Tadokoro Y, Naka K, Ino Y, Todo T, Kuratsu J, Saya H, Hamada J, Hirao A　CANCER RESEARCH　2011/01
  • 　TGF-FOXO signalling maintains leukaemia-initiating cells in chronic myeoid leukaemia. 　Naka K, Hoshii T, Muraguchi T, Tadokoro Y, Ooshio T, Kondo Y, Nakao S, Motoyama N, Hirao A　NATURE　2010/02
  • 　Identification of tumor-initiating cells in a highly aggressive brain tumor using promoter activity of nucleostemin.　Tamase A, Muraguchi T, Naka K, Tanaka S, Kinoshita M, Hoshii T, Ohmura M, Shugo H, Ooshio T, Nakada M, Sawamoto K, Onodera M, Matsumoto K, Oshima M, Asano M, Saya H, Okano H, Suda T, Hamada JI, Hirao A. 　PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AME
  • 　 Identification of Stem Cells During Prepubertal Spermatogenesis Via Monitoring of　Nucleostemin Promoter Activity　Ohmura M, Naka K, Hoshii T, Muraguchi T, Shugo H, Tamase A, Uema N, Ooshio T, Arai F, Takubo K, Nagamatsu G, Hamaguchi I, Takagi M, Ishihara M, Sakurada K, Miyaji H, Suda T, Hirao A.　STEM CELLS

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  • 　Foxo3a is essential for maintenance of the hematopoietic stem cell pool. Cell Stem Cell. 　Miyamoto K, Araki YK, Naka K, Arai F, Takubo K, Yamazaki S, Matsuoka S, Miyamoto T, Ito K, Ohmura M, Chen C, Hosokawa K, Nakauchi H, Nakayama K, Nakayama KI, Harada M, Motoyama N, Suda T, and Hirao A.
  • 　Regulation of oxidative stress by ATM is required for the self-renewal of haematopoietic stem cells.　NATURE　431　997-1002　2004/10
  • 　Tie2/Angiopoietin-1 Signaling Regulates Hematopoietic Stem Cell Quiescence in the Bone Marrow Niche.　CELL　118　149-61　2004/06
  • 　DNA damage-induced activation of p53 by the checkpoint kinase Chk2.　SCIENCE　287　1824-7　2000/03

Conference Presentations

Others

  • 　Cross-talk between Chk1 and Chk2 in double-mutant thymocytes.　Zaugg K, Su YW, Reilly PT, Moolani Y, Cheung CC, Hakem R, Hirao A, Liu Q, Elledge SJ, Mak TW.　104　10　3805-10　2007/03
  • 　ATM can regulate p53 and neuronal death independent of Chk2 in response to DNA damage.　Keramaris E, Hirao A, Slack RS, Mak TW, Park DS.　278　39　37782-9　2003/09

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「核小体分子の発現・機能解析による正常および白血病幹細胞の未分化性維持機構の解明」(2006-)　
○「がん病理・病態学的特性の分子基盤の解析とそれに基づく診断・治療法の開発に関する研究」(2007-)　
○「細胞老化・寿命制御シグナルによる白血病幹細胞の発生・維持・分化」(2009-)　
○「普遍的幹細胞制御機構と腫瘍細胞分化」(2008-)　
○「がんの幹細胞特性を支える栄養シグナル制御機構の解明」(2012-2014)　
○「がん幹細胞性獲得・維持機構とニッチシグナルのクロストーク」(2011-2012)　
○「マルチオミクス解析システムによる白血病幹細胞分化制御機構の解明」(2011-2011)　
○「腫瘍悪性度進展における未分化性獲得メカニズムの解明」(2010-2010)　
○「細胞老化・寿命制御シグナルによる白血病幹細胞の発生・維持・分化」(2009-2011)　

Competitive research funding,Contribution

Collaborative research,Consignment study

○Identification of Cancer Stem Cells(2005-)

Classes (Bachelors)

Classes (Graduate Schools)

○Seminar on Tumor Biology(2017)
○Molecular Medical Oncology(2017)
○Biology of Cancer 2A(2017)
○Biology of Cancer 2B(2017)
○Cancer molecular pathology 2(2017)
○Cancer molecular pathology 2(2017)
○Cancer molecular pathology 2(2017)
○Cancer molecular pathology 2(2017)
○Stem Cell Biology(2017)
○Molecular Oncology(2017)
○Seminar on Tumor Biology(2017)
○Stem Cell Biology(2017)
○Advanced Medical and Pharmaceutical Sciences(2017)
○Stem Cell Biology(2017)
○Advanced Medical and Pharmaceutical Sciences(2017)
○Medical Sciences(2016)
○Stem Cell Biology(2016)
○Stem Cell Biology(2016)
○Stem Cell Biology(2016)
○Molecular Oncology(2016)
○Cancer molecular pathology 2(2016)
○Biology of Cancer 2A(2016)
○Biology of Cancer 2B(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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