last modified：2026/05/27
Professor KOGA Tomoaki
Faculty, Affiliation
Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences Laboratory of Inflammatory Memory Medicine, Division of Pharmaceutical Sciences, Graduate School of Medical Sciences
Professor
College and School Educational Field
Division of Health Sciences, Graduate School of Phamaceutical Science
Division of Pharmaceutical Sciences, Graduate School of Medical Science
School of Pharmacy, College of Medical, Pharmaceutical and Health Sciences
Laboratory
Laboratory of Inflammatory Memory Medicine
Academic Background
Career
Kumamoto University Institute of Molecular Embryology and Genetics(2017/04-2021/04)
Kanazawa University(2026/04-)
Kumamoto University Institute of Molecular Embryology and Genetics(2026/04-)
Juntendo University Graduate School of Medicine(2016/05-)
Kumamoto University Institute of Molecular Embryology and Genetics(2021/05-2026/03)
Kumamoto University(2016/05-2017/03)
Juntendo University Graduate School of Medicine(2012/04-2016/04)
Kyushu University Faculty of Medical Sciences(2011/04-2012/03)
Japan Society for the Promotion of Science(2008/04-2011/03)
Kumamoto University Graduate School of Pharmaceutical Sciences(2005/04-2008/03)
University of Rochester(2005/10-2007/12)
(2005/08-2005/09)
Kumamoto University School of Pharmacy(1999/04-2003/03)
Kumamoto University Graduate School of Pharmaceutical Sciences(2003/04-2005/03)
Year & Month of Birth
Academic Society
Award
Specialities
Speciality Keywords
Inflammation memory,epigenetics,lipid mediator,epithelial cells,T cell,macrophage,Dendritic cells,Lipid Immunology,GPCR,Lipid,Immunology,Inflammation
Research Themes
Books
- KOGA TOMOAKI,YOKOMIZO TAKEHIKO Bioactive Lipid Mediators Springer Japan 2015
- KOGA TOMOAKI Clinical Immunology & Allergy 2018/09
Papers
- IL-6-driven POU2AF1 and ELL2 are key regulators of multiple myeloma-distinct transcriptional and splicing programs. Yasuyo Ohguchi,Masahiko Ajiro,Daisuke Ogiya,Takeshi Masuda,Yawara Kawano,Shingo Usuki,Tomoaki Koga,Shinjiro Hino Dr,Takeshi Harada,Satoru Takahashi,Seiji Okada,Jun-Ichirou Yasunaga,Goro Sashida,Sumio Ohtsuki,Mitsuyoshi Nakao,Takashi Minami,Akihide Yoshimi,Hiroto Ohguchi Blood advances 2026/04/02
- Histone demethylase KDM7A negatively regulates fibrotic macrophage polarization and lung fibrosis progression. Naofumi Funagura,Tomoaki Koga,Kan Etoh,Seonghyeon Hong,Hidenori Ichiyasu,Yukio Fujijwara,Kei-Ichiro Yasunaga,Shingo Usuki,Ayane Noda,Akihito Sagara,Shinjiro Hino,Yoshihiro Komohara,Takuro Sakagami,Toshihiro Inoue,Mitsuyoshi Nakao Communications biology 2026/01/23
- Epigenetic Dysregulation of the
NKX2 ‐1/SPDEF Axis Drives Persistent Goblet Cell Differentiation and Epithelial Barrier Dysfunction in Chronic Obstructive Pulmonary Disease Ayaka Shiota,Keiko Kan‐o,Yumiko Ishii,Tomoaki Koga,Takeshi Sawada,Kei‐ichiro Yasunaga,Shingo Usuki,Tatsuya Katsuno,Shigesato Inoue,Tomohiro Ogawa,Akihiro Jo,Satoru Fukuyama,Mitsuyoshi Nakao,Hiroaki Ogata,Mizuho A. Kido,Sachiko Tsukita,Koichiro Matsumoto,Isamu Okamoto Respirology 2026/01/20
- Claudin-3 deficiency inhibits allergic responses in an ovalbumin-induced asthma mouse model. Yumiko Ishii,Ayaka Shiota,Tomoaki Takao,Norio Yamamoto,Tomohiro Ogawa,Akihiro Jo,Seiji Shinozaki,Satoru Fukuyama,Tomoaki Koga,Minako Ito,Hiroo Tanaka,Atsushi Tamura,Sachiko Tsukita,Koichiro Matsumoto,Isamu Okamoto,Keiko Kan-O Allergology international : official journal of the Japanese Society of Allergology 74 3 472 2025/07
- KEAP1 retention in phase-separated p62 bodies drives liver damage under autophagy-deficient conditions. Shuhei Takada,Nozomi Shinomiya,Gaoxin Mao,Hikaru Tsuchiya,Tomoaki Koga,Satoko Komatsu-Hirota,Yu-Shin Sou,Manabu Abe,Elena Ryzhii,Michitaka Suzuki,Mitsuyoshi Nakao,Satoshi Waguri,Hideaki Morishita,Masaaki Komatsu EMBO reports 26 13 3384 2025/07
- Citrate metabolism controls the senescent microenvironment via the remodeling of pro-inflammatory enhancers. Kan Etoh,Hirotaka Araki,Tomoaki Koga,Yuko Hino,Kanji Kuribayashi,Shinjiro Hino,Mitsuyoshi Nakao Cell reports 114496 2024/07/17
- Phosphorylation of phase-separated p62 bodies by ULK1 activates a redox-independent stress response. Ryo Ikeda,Daisuke Noshiro,Hideaki Morishita,Shuhei Takada,Shun Kageyama,Yuko Fujioka,Tomoko Funakoshi,Satoko Komatsu-Hirota,Ritsuko Arai,Elena Ryzhii,Manabu Abe,Tomoaki Koga,Hozumi Motohashi,Mitsuyoshi Nakao,Kenji Sakimura,Arata Horii,Satoshi Waguri,Yoshinobu Ichimura,Nobuo N Noda,Masaaki Komatsu The EMBO journal e113349 2023/06/12
- Lactic acidosis induces metabolic and phenotypic reprogramming in cholangiocarcinoma cells via the upregulation of
THBS1 Ubonrat Thamrongwaranggoon,Kanji Kuribayashi,Hirotaka Araki,Yuko Hino,Tomoaki Koga,Wunchana Seubwai,Sopit Wongkham,Mitsuyoshi Nakao,Shinjiro Hino Cancer Science 2022/12/23 - Lactic acidosis promotes aggressive features of cholangiocarcinoma cells via upregulating ALDH1A3 expression through EGFR axis. Ubonrat Thamrongwaranggoon,Marutpong Detarya,Wunchana Seubwai,Charupong Saengboomee,Shinjiro Hino,Tomoaki Koga,Mitsuyoshi Nakao,Sopit Wongkham Life sciences 302 120648 2022/05/19
- Loss of the transcription repressor ZHX3 induces senescence-associated gene expression and mitochondrial-nucleolar activation. Tomoka Igata,Hiroshi Tanaka,Kan Etoh,Seonghyeon Hong,Naoki Tani,Tomoaki Koga,Mitsuyoshi Nakao PloS one 17 1 e0262488 2022
- Computational analysis of morphological and molecular features in gastric cancer tissues. Yoko Yasuda,Kazuaki Tokunaga,Tomoaki Koga,Chiyomi Sakamoto,Ilya G Goldberg,Noriko Saitoh,Mitsuyoshi Nakao Cancer medicine 9 6 2223 2020/03
- Leukotriene B4 receptor 1 exacerbates inflammation following myocardial infarction. Yuma Horii,Michio Nakaya,Hiroki Ohara,Hiroaki Nishihara,Kenji Watari,Akiomi Nagasaka,Takeo Nakaya,Yuki Sugiura,Toshiaki Okuno,Tomoaki Koga,Akira Tanaka,Takehiko Yokomizo,Hitoshi Kurose FASEB journal : official publication of the Federation of American Societies for Experimental Biology 34 6 8749 2020/06
- Leukotriene A4 hydrolase deficiency protects mice from diet-induced obesity by increasing energy expenditure through neuroendocrine axis. Hirotsugu Uzawa,Daisuke Kohno,Tomoaki Koga,Tsutomu Sasaki,Ayako Fukunaka,Toshiaki Okuno,Airi Jo-Watanabe,Saiko Kazuno,Takeshi Miyatsuka,Tadahiro Kitamura,Yoshio Fujitani,Hirotaka Watada,Kazuko Saeki,Takehiko Yokomizo FASEB journal : official publication of the Federation of American Societies for Experimental Biology 34 10 13949 2020/08/26
- Expression of leukotriene B4 receptor 1 defines functionally distinct DCs that control allergic skin inflammation. Tomoaki Koga,Fumiyuki Sasaki,Kazuko Saeki,Soken Tsuchiya,Toshiaki Okuno,Mai Ohba,Takako Ichiki,Satoshi Iwamoto,Hirotsugu Uzawa,Keiko Kitajima,Chikara Meno,Eri Nakamura,Norihiro Tada,Yoshinori Fukui,Junichi Kikuta,Masaru Ishii,Yukihiko Sugimoto,Mitsuyoshi Nakao,Takehiko Yokomizo Cellular & molecular immunology 18 6 1437 2020/10/09
- High glucose-ROS condition enhances progression in cholangiocarcinoma via upregulation of MAN2A2 and CHD8. Unchalee Thonsri,Sopit Wongkham,Chaisiri Wongkham,Shinjiro Hino,Mitsuyoshi Nakao,Sittiruk Roytrakul,Tomoaki Koga,Wunchana Seubwai Cancer science 112 1 254 2020/11/03
- Cellular Senescence Variation by Metabolic and Epigenomic Remodeling. Mitsuyoshi Nakao,Hiroshi Tanaka,Tomoaki Koga Trends in cell biology 2020/09/23
- The NSD2/WHSC1/MMSET methyltransferase prevents cellular senescence-associated epigenomic remodeling. Hiroshi Tanaka,Tomoka Igata,Kan Etoh,Tomoaki Koga,Shin-Ichiro Takebayashi,Mitsuyoshi Nakao Aging cell 2020/06/22
- α1-acid glycoprotein attenuates adriamycin-induced nephropathy via CD163 expressing macrophages induction Rui Fujimura,Hiroshi Watanabe,Kento Nishida,Yukio Fujiwara,Tomoaki Koga,Jing Bi,Tadashi Imafuku,Kazuki Kobayashi,Hisakazu Komori,Masako Miyahisa,Hitoshi Maeda,Motoko Tanaka,Kazutaka Matsushita,Takashi Wada,Masafumi Fukagawa,Toru Maruyama Kidney360 in press 5 10.34067/KID.0000782019 2020/03/24
- BLT1 mediates commensal bacteria-dependent innate immune signals to enhance antigen-specific intestinal IgA responses. Nagatake T,Hirata SI,Koga T,Kuroda E,Kobari S,Suzuki H,Hosomi K,Matsumoto N,Yanrismet Y,Shimojou M,Morimoto S,Sasaki F,Ishii KJ,Yokomizo T,Kunisawa J Mucosal immunology 12 5 1082 2019/05
- Leukotriene B4 promotes neovascularization and macrophage recruitment in murine wet-type AMD models. Fumiyuki Sasaki,Tomoaki Koga,Mai Ohba,Kazuko Saeki,Toshiaki Okuno,Keijiro Ishikawa,Takahito Nakama,Shintaro Nakao,Shigeo Yoshida,Tatsuro Ishibashi,Hamid Ahmadieh,Mozhgan Rezaei Kanavi,Ali Hafezi-Moghadam,Josef M Penninger,Koh-Hei Sonoda,Takehiko Yokomizo JCI insight 3 18 2018/09/20
- Development of Kupffer cell targeting type-I interferon for the treatment of hepatitis via inducing anti-inflammatory and immunomodulatory actions. Yuki Minayoshi,Hitoshi Maeda,Hiroki Yanagisawa,Keisuke Hamasaki,Yuki Mizuta,Kento Nishida,Ryo Kinoshita,Yuki Enoki,Tadasi Imafuku,Victor Tuan Giam Chuang,Tomoaki Koga,Yukio Fujiwara,Motohiro Takeya,Kayoko Sonoda,Tomohiko Wakayama,Kazuaki Taguchi,Yu Ishima,Tatsuhiro Ishida,Yasuko Iwakiri,Motohiko Tanaka,Yutaka Sasaki,Hiroshi Watanabe,Masaki Otagiri,Toru Maruyama Drug delivery 25 1 1067 2018/11
- Profiling of bioactive lipids in different dendritic cell subsets using an improved multiplex quantitative LC-MS/MS method. Mai Ohba,Kazuko Saeki,Tomoaki Koga,Toshiaki Okuno,Yuichi Kobayashi,Takehiko Yokomizo Biochemical and biophysical research communications 504 3 562 2018/10/07
- Inhibition of local macrophage growth ameliorates focal inflammation and suppresses atherosclerosis Sarie Yamada,Takafumi Senokuchi,Takeshi Matsumura,Yutaro Morita,Norio Ishii,Kazuki Fukuda,Saiko Murakami-Nishida,Shuhei Nishida,Shuji Kawasaki,Hiroyuki Motoshima,Noboru Furukawa,Yoshihiro Komohara,Yukio Fujiwara,Tomoaki Koga,Kazuya Yamagata,Motohiro Takeya,Eiichi Araki Arteriosclerosis, Thrombosis, and Vascular Biology 38 5 994 2018
- Inhibition of Leukotriene B-4 Action Mitigates Intracerebral Hemorrhage-Associated Pathological Events in Mice Masanori Hijioka,Junpei Anan,Hayato Ishibashi,Yuki Kurauchi,Akinori Hisatsune,Takahiro Seki,Tomoaki Koga,Takehiko Yokomizo,Takao Shimizu,Hiroshi Katsuki JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 360 3 399 2017/03
- Non-steroidal anti-inflammatory drug delays corneal wound healing by reducing production of 12-hydroxyheptadecatrienoic acid, a ligand for leukotriene B-4 receptor 2 Satoshi Iwamoto,Tomoaki Koga,Mai Ohba,Toshiaki Okuno,Masato Koike,Akira Murakami,Akira Matsuda,Takehiko Yokomizo SCIENTIFIC REPORTS 7 1 13267 2017/10
- Biochemical and immunological characterization of a novel monoclonal antibody against mouse leukotriene B-4 receptor 1 Fumiyuki Sasaki,Tomoaki Koga,Kazuko Saeki,Toshiaki Okuno,Saiko Kazuno,Tsutomu Fujimura,Yasuyuki Ohkawa,Takehiko Yokomizo PLOS ONE 12 9 e0185133 2017/09
- An aromatic amino acid within intracellular loop 2 of the prostaglandin EP2 receptor is a prerequisite for selective association and activation of G alpha s Akiko Yano,Yuko Takahashi,Hiromi Moriguchi,Tomoaki Inazumi,Tomoaki Koga,Akira Otaka,Yukihiko Sugimoto BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 1862 6 615 2017/06
- Generation and characterization of a human-mouse chimeric high-affinity antibody that detects the DYKDDDDK FLAG peptide Koki Ikeda,Tomoaki Koga,Fumiyuki Sasaki,Ayumi Ueno,Kazuko Saeki,Toshiaki Okuno,Takehiko Yokomizo BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 486 4 1077 2017/05
- Gut Microbiota Promotes Obesity-Associated Liver Cancer through PGE(2)-Mediated Suppression of Antitumor Immunity Tze Mun Loo,Fumitaka Kamachi,Yoshihiro Watanabe,Shin Yoshimoto,Hiroaki Kanda,Yuriko Arai,Yaeko Nakajima-Takagi,Atsushi Iwama,Tomoaki Koga,Yukihiko Sugimoto,Takayuki Ozawa,Masaru Nakamura,Miho Kumagai,Koichi Watashi,Makoto M. Taketo,Tomohiro Aoki,Shuh Narumiya,Masanobu Oshima,Makoto Arita,Eiji Hara,Naoko Ohtani CANCER DISCOVERY 7 5 522 2017/05
- An aromatic amino acid within intracellular loop 2 of the prostaglandin EP2 receptor is a prerequisite for selective association and activation of Gαs. Yano A,Takahashi Y,Moriguchi H,Inazumi T,Koga T,Otaka A,Sugimoto Y Biochimica et biophysica acta 1862 6 615 2017/03
- Mild electrical stimulation with heat shock guides differentiation of embryonic stem cells into Pdx1-expressing cells within the definitive endoderm Tomoaki Koga,Nobuaki Shiraki,Shuichiro Yano,Mary Ann Suico,Saori Morino-Koga,Takashi Sato,Tsuyoshi Shuto,Shoen Kume,Hirofumi Kai BMC BIOTECHNOLOGY 17 1 14 2017/02
- Podocyte p53 Limits the Severity of Experimental Alport Syndrome Ryosuke Fukuda,Mary Ann Suico,Yukari Kai,Kohei Omachi,Keishi Motomura,Tomoaki Koga,Yoshihiro Komohara,Kosuke Koyama,Tsubasa Yokota,Manabu Taura,Tsuyoshi Shuto,Hirofumi Kai JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 27 1 144 2016/01
- Modulation of leukotriene B4 receptor 1 signaling by receptor for advanced glycation end products (RAGE) Takako Ichiki,Tomoaki Koga,Toshiaki Okuno,Kazuko Saeki,Yasuhiko Yamamoto,Hiroshi Yamamoto,Masakiyo Sakaguchi,Takehiko Yokomizo FASEB JOURNAL 30 5 1811 2016/05
- Receptor for Advanced Glycation End Products Regulates Leukotriene B-4 Receptor 1 Signaling Takako Ichiki,Tomoaki Koga,Takehiko Yokomizo DNA AND CELL BIOLOGY 35 12 747 2016/12
- Leukotriene B-4 receptor type 2 protects against pneumolysin-dependent acute lung injury Misako Shigematsu,Tomoaki Koga,Ayako Ishimori,Kazuko Saeki,Yumiko Ishii,Yoshitaka Taketomi,Mai Ohba,Airi Jo-Watanabe,Toshiaki Okuno,Norihiro Harada,Takeshi Harayama,Hideo Shindou,Jian-Dong Li,Makoto Murakami,Sumio Hoka,Takehiko Yokomizo SCIENTIFIC REPORTS 6 34560 2016/10
- Receptor for advanced glycation endproducts modulates leukotriene B-4 receptor 1 signaling Takako Ichiki,Tomoaki Koga,Toshiaki Okuno,Kazuko Saeki,Yasuhiko Yamamoto,Masakiyo Sakaguchi,Takehiko Yokomizo FASEB JOURNAL 30 2016/04
- Leukotriene B-4 receptor type 2 (BLT2) enhances skin barrier function by regulating tight junction proteins Yumiko Ishii,Kazuko Saeki,Min Liu,Fumiyuki Sasaki,Tomoaki Koga,Keiko Kitajima,Chikara Meno,Toshiaki Okuno,Takehiko Yokomizo FASEB JOURNAL 30 2 933 2016/02
- Endoplasmic Reticulum (ER) Stress Induces Sirtuin 1 (SIRT1) Expression via the PI3K-Akt-GSK3 beta Signaling Pathway and Promotes Hepatocellular Injury Tomoaki Koga,Mary Ann Suico,Shogo Shimasaki,Eriko Watanabe,Yukari Kai,Kosuke Koyama,Kohei Omachi,Saori Morino-Koga,Takashi Sato,Tsuyoshi Shuto,Kazutoshi Mori,Shinjiro Hino,Mitsuyoshi Nakao,Hirofumi Kai JOURNAL OF BIOLOGICAL CHEMISTRY 290 51 30366 2015/12
- 12-hydroxyheptadecatrienoic acid promotes epidermal wound healing by accelerating keratinocyte migration via the BLT2 receptor Min Liu,Kazuko Saeki,Takehiko Matsunobu,Toshiaki Okuno,Tomoaki Koga,Yukihiko Sugimoto,Chieko Yokoyama,Satoshi Nakamizo,Kenji Kabashima,Shuh Narumiya,Takao Shimizu,Takehiko Yokomizo JOURNAL OF EXPERIMENTAL MEDICINE 211 6 1063 2014/06
- Insulin receptor activation through its accumulation in lipid rafts by mild electrical stress Saori Morino-Koga,Shuichiro Yano,Tatsuya Kondo,Yuichiro Shimauchi,Shingo Matsuyama,Yuka Okamoto,Mary Ann Suico,Tomoaki Koga,Takashi Sato,Tsuyoshi Shuto,Hidetoshi Arima,Ikuo Wada,Eiichi Araki,Hirofumi Kai Journal of Cellular Physiology 228 2 439 2013/02
- Inhibition of PDE4B suppresses inflammation by increasing expression of the deubiquitinase CYLD Kensei Komatsu,Ji-Yun Lee,Masanori Miyata,Jae Hyang Lim,Hirofumi Jono,Tomoaki Koga,Haidong Xu,Chen Yan,Hirofumi Kai,Jian-Dong Li Nature Communications 4 1684 2013
- CYLD negatively regulates transforming growth factor-beta-signalling via deubiquitinating Akt Jae Hyang Lim,Hirofumi Jono,Kensei Komatsu,Chang-Hoon Woo,Jiyun Lee,Masanori Miyata,Takashi Matsuno,Xiangbin Xu,Yuxian Huang,Wenhong Zhang,Soo Hyun Park,Yu-Il Kim,Yoo-Duk Choi,Huahao Shen,Kyung-Sun Heo,Haodong Xu,Patricia Bourne,Tomoaki Koga,Haidong Xu,Chen Yan,Binghe Wang,Lin-Feng Chen,Xin-Hua Feng,Jian-Dong Li NATURE COMMUNICATIONS 3 771 2012/04
- STT3B-Dependent Posttranslational N-Glycosylation as a Surveillance System for Secretory Protein Takashi Sato,Yasuhiro Sako,Misato Sho,Mamiko Momohara,Mary Ann Suico,Tsuyoshi Shuto,Hideki Nishitoh,Tsukasa Okiyoneda,Koichi Kokame,Masayuki Kaneko,Manabu Taura,Masanori Miyata,Keisuke Chosa,Tomoaki Koga,Saori Morino-Koga,Ikuo Wada,Hirofumi Kai MOLECULAR CELL 47 1 99 2012/07
- Mild Electrical Stimulation and Heat Shock Ameliorates Progressive Proteinuria and Renal Inflammation in Mouse Model of Alport Syndrome Tomoaki Koga,Yukari Kai,Ryosuke Fukuda,Saori Morino-Koga,Mary Ann Suico,Kosuke Koyama,Takashi Sato,Tsuyoshi Shuto,Hirofumi Kai PLOS ONE 7 8 e43852 2012/08
- Lucidenic acids-rich extract from antlered form of Ganoderma lucidum enhances TNFα induction in THP-1 monocytic cells possibly via its modulation of MAP kinases p38 and JNK Kenji Watanabe,Tsuyoshi Shuto,Miki Sato,Kouhei Onuki,Shota Mizunoe,Shingo Suzuki,Takashi Sato,Tomoaki Koga,Mary Ann Suico,Hirofumi Kai,Tsuyoshi Ikeda Biochemical and Biophysical Research Communications 408 1 18 2011/04/29
- CFTR-deficiency renders mice highly susceptible to cutaneous symptoms during mite infestation Yasuaki Hashimoto,Tsuyoshi Shuto,Shota Mizunoe,Azusa Tomita,Tomoaki Koga,Takashi Sato,Motohiro Takeya,Mary Ann Suico,Akiko Niibori,Takuya Sugahara,Shogo Shimasaki,Takashi Sugiyama,Bob Scholte,Hirofumi Kai LABORATORY INVESTIGATION 91 4 509 2011/04
- Lucidenic acids-rich extract from antlered form of Ganoderma lucidum enhances TNF alpha induction in THP-1 monocytic cells possibly via its modulation of MAP kinases p38 and JNK Kenji Watanabe,Tsuyoshi Shuto,Miki Sato,Kouhei Onuki,Shota Mizunoe,Shingo Suzuki,Takashi Sato,Tomoaki Koga,Mary Ann Suico,Hirofumi Kai,Tsuyoshi Ikeda BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 408 1 18 2011/04
- MEF/ELF4 transactivation by E2F1 is inhibited by p53 Manabu Taura,Mary Ann Suico,Ryosuke Fukuda,Tomoaki Koga,Tsuyoshi Shuto,Takashi Sato,Saori Morino-Koga,Seiji Okada,Hirofumi Kai NUCLEIC ACIDS RESEARCH 39 1 76 2011/01
- Glucose Uptake in Rat Skeletal Muscle L6 Cells Is Increased by Low-Intensity Electrical Current Through the Activation of the Phosphatidylinositol-3-OH Kinase (PI-3K)/Akt Pathway Shuichiro Yano,Saori Morino-Koga,Tatsuya Kondo,Mary Ann Suico,Tomoaki Koga,Yuichiro Shimauchi,Shingo Matsuyama,Tsuyoshi Shuto,Takashi Sato,Eiichi Araki,Hirofumi Kai JOURNAL OF PHARMACOLOGICAL SCIENCES 115 1 94 2011/01
- Posttranslational negative regulation of glycosylated and non-glycosylated BCRP expression by Derlin-1 Takashi Sugiyama,Tsuyoshi Shuto,Shingo Suzuki,Takashi Sato,Tomoaki Koga,Mary Ann Suico,Hiroyuki Kusuhara,Yuichi Sugiyama,Douglas M. Cyr,Hirofumi Kai BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 404 3 853 2011/01
- Role of the Glutamic Acid 54 Residue in Transthyretin Stability and Thyroxine Binding Masanori Miyata,Takashi Sato,Mineyuki Mizuguchi,Teruya Nakamura,Shinji Ikemizu,Yuko Nabeshima,Seiko Susuki,Yoshiaki Suwa,Hiroshi Morioki,Yukio Ando,Mary Ann Suico,Tsuyoshi Shuto,Tomoaki Koga,Yuriko Yamagata,Hirofumi Kai BIOCHEMISTRY 49 1 114 2010/01
- Curcumin decreases toll-like receptor-2 gene expression and function in human monocytes and neutrophils Tsuyoshi Shuto,Tomomi Ono,Yuko Ohira,Shogo Shimasaki,Shota Mizunoe,Kenji Watanabe,Mary Ann Suico,Tomoaki Koga,Takashi Sato,Saori Morino,Keizo Sato,Hirofumi Kai BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 398 4 647 2010/08
- Modified Mild Heat Shock Modality Attenuates Hepatic Ischemia/Reperfusion Injury Mariko Oba,Ann Suico,Saori Morino,Shuichiro Yano,Takashi Matsuno,Tomoaki Koga,Takashi Sato,Tsuyoshi Shuto,Hirofumi Kai JOURNAL OF SURGICAL RESEARCH 162 2 213 2010/08
- Endoplasmic reticulum stress increases the expression and function of toll-like receptor-2 in epithelial cells Shogo Shimasaki,Tomoaki Koga,Tsuyoshi Shuto,Mary Ann Suico,Takashi Sato,Kenji Watanabe,Saori Morino-Koga,Manabu Taura,Seiji Okada,Kazutoshi Mori,Hirofumi Kai BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 402 2 235 2010/11
- TLR3 induction by anticancer drugs potentiates poly I:C-induced tumor cell apoptosis Manabu Taura,Ryosuke Fukuda,Mary Ann Suico,Ayaka Eguma,Tomoaki Koga,Tsuyoshi Shuto,Takashi Sato,Saori Morino-Koga,Hirofumi Kai CANCER SCIENCE 101 7 1610 2010/07
- The Crystal Structure of the Green Tea Polyphenol (-)-Epigallocatechin Gallate-Transthyretin Complex Reveals a Novel Binding Site Distinct from the Thyroxine Binding Site Masanori Miyata,Takashi Sato,Miyuki Kugimiya,Misato Sho,Teruya Nakamura,Shinji Ikemizu,Mami Chirifu,Mineyuki Mizuguchi,Yuko Nabeshima,Yoshiaki Suwa,Hiroshi Morioka,Takao Arimori,Mary Ann Suico,Tsuyoshi Shuto,Yasuhiro Sako,Mamiko Momohara,Tomoaki Koga,Saori Morino-Koga,Yuriko Yamagata,Hirofumi Kai BIOCHEMISTRY 49 29 6104 2010/07
- TLR3 induction by anticancer drugs potentiates poly I:C-induced tumor cell apoptosis. Manabu Taura,Ryosuke Fukuda,Mary Ann Suico,Ayaka Eguma,Tomoaki Koga,Tsuyoshi Shuto,Takashi Sato,Saori Morino-Koga,Hirofumi Kai Cancer science 101 7 1610 2010/07
- Calreticulin positively regulates the expression and function of epithelial sodium channel Takuya Sugahara,Tomoaki Koga,Keiko Ueno-Shuto,Tsuyoshi Shuto,Eriko Watanabe,Ai Maekawa,Kenichiro Kitamura,Kimio Tomita,Ai Mizuno,Takashi Sato,Mary Ann Suico,Hirofumi Kai EXPERIMENTAL CELL RESEARCH 315 19 3294 2009/11
- p53 Regulates Toll-Like Receptor 3 Expression and Function in Human Epithelial Cell Lines Manabu Taura,Ayaka Eguma,Mary Ann Suico,Tsuyoshi Shuto,Tomoaki Koga,Kensei Komatsu,Takefumi Komune,Takashi Sato,Hideyuki Saya,Jian-Dong Li,Hirofumi Kai MOLECULAR AND CELLULAR BIOLOGY 28 21 6557 2008/11
- Tumor suppressor cylindromatosis acts as a negative regulator for Streptococcus pneumoniae-induced NFAT signaling Tomoaki Koga,Jae Hyang Lim,Hirofumi Jono,Un Hwan Ha,Haidong Xu,Hajime Ishinaga,Saori Morino,Xiangbin Xu,Chen Yan,Hirofumi Kai,Jian-Dong Li JOURNAL OF BIOLOGICAL CHEMISTRY 283 18 12546 2008/05
- Nontypeable Haemophilus influenzae induces COX-2 and PGE2 expression in lung epithelial cells via activation of p38 MAPK and NF-kappa B Feng Xu,Zhihao Xu,Rong Zhang,Zuqun Wu,Jae-Hyang Lim,Tomoaki Koga,Jian-Dong Li,Huahao Shen RESPIRATORY RESEARCH 9 16 2008/01
- Heat shock suppresses human NK cell cytotoxicity via regulation of perforin Hideki Harada,Toru Murakami,Seow Shi Tea,Akira Takeuchi,Tomoaki Koga,Seiji Okada,Mary Ann Suico,Tsuyoshi Shuto,Hirofumi Kai INTERNATIONAL JOURNAL OF HYPERTHERMIA 23 8 657 2007/12
- Tumor Suppressor CYLD Acts as a Negative Regulator for Non-Typeable Haemophilus influenza-Induced Inflammation in the Middle Ear and Lung of Mice Jae Hyang Lim,Hirofumi Jono,Tomoaki Koga,Chang-Hoon Woo,Hajime Ishinaga,Patricia Bourne,Haodong Xu,Un-Hwan Ha,Haidong Xu,Jian-Dong Li PLOS ONE 2 10 e1032 2007/10
- Opposing roles of PAK2 and PAK4 in synergistic or MUC5AC mucin by bacterium NTHi and induction EGF Yuxian Huang,Fumi Mikami,Hirofumi Jono,Wenhong Zhang,Xinhua Weng,Tomoaki Koga,Haidong Xu,Chen Yan,Hirofumi Kai,Jian-Dong Li BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 359 3 691 2007/08
- Tumor suppressor CYLD regulates acute lung injury in lethal Streptococcus pneumoniae infections Jae Hyang Lim,Brigid Stirling,Jonathan Derry,Tomoaki Koga,Hirofumi Jono,Chang-Hoon Woo,Haodong Xu,Patricia Bourne,Un-Hwan Ha,Hajime Ishinaga,Haidong Xu,Ali Andalibi,Xin-Hua Feng,Hongguang Zhu,Yuxian Huang,Wenhong Zhang,Xinhua Weng,Chen Yan,Zhinan Yin,David E. Briles,Roger J. Davis,Richard A. Flavell,Jian-Dong Li IMMUNITY 27 2 349 2007/08
- The bacterium, nontypeable Haemophilus influenzae, enhances host antiviral response by inducing Toll-like receptor 7 expression - Evidence for negative regulation of host antiviral response by CYLD Akihiro Sakai,Tomoaki Koga,Jae-Hyang Lim,Hirofumi Jono,Kazutsune Harada,Erika Szymanski,Haidong Xu,Hirofumi Kai,Jian-Dong Li FEBS JOURNAL 274 14 3655 2007/07
- A novel role for I kappa B kinase (IKK) alpha and IKK beta in ERK-dependent up-regulation of MUC5AC mucin transcription by Streptococcus pneumoniae Unhwan Ha,Jae Hyang Lim,Hirofumi Jono,Tomoaki Koga,Amit Srivastava,Richard Malley,Gilles Pages,Jacques Pouyssegur,Jian-Dong Li JOURNAL OF IMMUNOLOGY 178 3 1736 2007/02
- TGF-beta induces p65 acetylation to enhance bacteria-induced NF-kappa B activation Hajime Ishinaga,Hirofumi Jono,Jae Hyang Lim,Soo-Mi Kweon,Haodong Xu,Un-Hwan Ha,Haidong Xu,Tomoaki Koga,Chen Yan,Xin-Hua Feng,Lin-Feng Chen,Jian-Dong Li EMBO JOURNAL 26 4 1150 2007/02
- Synergistic activation of NF-kappa B by nontypeable H-influenzae and S-pneumoniae is mediated by CK2, IKK beta-I kappa B alpha, and p38 MAPK Soo-Mi Kweon,Beinan Wang,Davida Rixter,Jae Hyang Lim,Tomoaki Koga,Hajime Ishinaga,Lin-Feng Chen,Hirofumi Jono,Haidong Xu,Jian-Dong Li BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 351 2 368 2006/12
- The transforming growth factor-beta-Smad3/4 signaling pathway acts as a positive regulator for TLR2 induction by bacteria via a dual mechanism involving functional cooperation with NF-kappa B and MAPK phosphatase 1-dependent negative cross-talk with p38 MAPK Fumi Mikami,Jae Hyang Lim,Hajime Ishinaga,Un-Hwan Ha,He Gu,Tomoaki Koga,Hirofumi Jono,Hirofumi Kai,Jian-Dong Li JOURNAL OF BIOLOGICAL CHEMISTRY 281 31 22397 2006/08
- Hyperthermia suppresses the cytotoxicity of NK cells via down-regulation of perforin/granzyme B expression T Koga,H Harada,TS Shi,S Okada,MA Suico,T Shuto,H Kai BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 337 4 1319 2005/12
- Sp1-dependent regulation of Myeloid Elf-1 like factor in human epithelial cells T Koga,MA Suico,H Nakamura,M Taura,Z Lu,T Shuto,T Okiyoneda,H Kai FEBS LETTERS 579 13 2811 2005/05
- Sp1 is involved in the transcriptional activation of lysozyme in epithelial cells MA Suico,T Koga,T Shuto,A Hisatsune,Z Lu,C Basbaum,T Okiyoneda,H Kai BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 324 4 1302 2004/11
- The regulation of human beta-defensin 2 by the ETS transcription factor MEF (myeloid elf-1-like factor) is enhanced by promyelocytic leukemia protein MA Suico,Z Lu,T Shuto,T Koga,T Uchikawa,H Yoshida,K Matsuzaki,M Nakao,JD Li,H Kai JOURNAL OF PHARMACOLOGICAL SCIENCES 95 4 466 2004/08
- 微弱パルス電流併用によるハイパーサーミアの適応拡大に関する基礎的検討 森野 沙緒里,古賀 友紹,大庭 真理子,矢野 脩一朗,メリーアン・スイコ,首藤 剛,近藤 龍也,荒木 栄一,甲斐 広文 Thermal Medicine 25 1 (29) 2009/03
- Receptor for advanced glycation endproducts modulates leukotriene B-4 receptor 1 signaling Takako Ichiki,Tomoaki Koga,Toshiaki Okuno,Kazuko Saeki,Yasuhiko Yamamoto,Masakiyo Sakaguchi,Takehiko Yokomizo FASEB JOURNAL 30 2016/04
- Leukotriene B 4receptors Tomoaki Koga,Takehiko Yokomizo Bioactive Lipid Mediators: Current Reviews and Protocols 85 2015/01/01
- E2F1によるMEF/ELF4トランスアクチべーションはp53により抑制される(MEF/ELF4 Transactivation by E2F1 is Inhibited by p53) Suico Mary Ann,Taura Manabu,Fukuda Ryosuke,Shuto Tsuyoshi,Koga Tomoaki,Sato Takashi,Kai Hirofumi 日本癌学会総会記事 70回 156 2011/09
Conference Presentations
- Regulation of monocytic cell subsets by lipid mediator and epigenome(2019/12/05)
- BLT1 as a marker for novel dendritic subset(2014/07/04)