Jump to contents

Researcher Information

last modified：2024/11/21

Assistant Professor　MUNESUE Seiichi

Mail Laboratory Website

Faculty, Affiliation

Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences　Biochemistry and Molecular Vascular Biology
Assistant Professor

College and School Educational Field

Division of Medical Sciences, Graduate School of Medical Science
Division of Medicine, Graduate School of Medical Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences
School of Medicine, College of Medical, Pharmaceutical and Health Sciences
School of Medicine, College of Medical, Pharmaceutical and Health Sciences

Laboratory

　TEL:076-265-2181　FAX:076-234-4217

Academic Background

【Degree】
biotechnology

Career

Postdoctoral fellow　Facul.of engineering, Kyoto Sangyo Univ　Postdoctoral fellow(2002/04-2005/03)
assistant professor　Facl. of engineering, Kyoto Sangyo Univ.　assistant professor(2005/04-2007/03)
assistant professor　Dept. of Molecular Vascular Biology(2007/04-)

Year & Month of Birth

1971/08

Academic Society



Award

Specialities

General medical chemistry

Speciality Keywords

Research Themes

Analysis of the mechanism of diabetes complecation development

Books

  • 　HMGB1-RAGE系を標的とした抗腫瘍効果について　2018
  • 　Munesue, S., Yoshitomi, Y., Kusano, Y., Koyama, Y., Nishiyama, A., Nakanishi, H., Miyazaki, K., Ishimaru, T., Miyaura, S., Okayama, M. and Oguri, K.　A novel function of syndecan-2, suppression of MMP-2 activation, which causes suppression of metastasis.　282　 28164-28174　2007

Papers

  • 　Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice.　Yamamoto Y, Liang M, Munesue S, Deguchi K, Harashima A, Furuhara K, Yuhi T, Zhong J, Akther S, Goto H, Eguchi Y, Kitao Y, Hori O, Shiraishi Y, Ozaki N, Shimizu Y, Kamide T, Yoshikawa A, Hayashi Y, Nakada M, Lopatina O, Gerasimenko M, Komleva Y, Malinovskaya N, Salmina AB, Asano M, Nishimori K, Shoelson SE, Yamamoto H, Higashida H.　Commun Biol.　2　76　2019/02/25
  • 　Transport of oxytocin to the brain after peripheral administration by membrane‐bound or soluble forms of receptors for advanced glycation end‐products　 Munesue S, Liang M, Harashima A, Zhong J, Furuhara K, Boitsova BE, Cherepanov MS, Gerasimenko M, Yuhi T, Yamamoto Y, Higashida H. 　J Neuroendocrinol. 　2021/03
  • 　Citrullinated Histone H3: Early Biomarker of Neutrophil Extracellular Traps in Septic Liver Damage.　Nomura K, Miyashita T, Yamamoto Y, Munesue S, Harashima A, Takayama H, Fushida S, Ohta T.　J Surg Res.　234　132-138.　2019
  • 　CD38, CD157, and RAGE as Molecular Determinants for Social Behavior.　Higashida H, Hashii M, Tanaka Y, Matsukawa S, Higuchi Y, Gabata R, Tsubomoto M, Seishima N, Teramachi M, Kamijima T, Hattori T, Hori O, Tsuji C, Cherepanov SM, Shabalova AA, Gerasimenko M, Minami K, Yokoyama S, Munesue SI, Harashima A, Yamamoto Y, Salmina AB, Lopatina O.　Cells　9　1　2019
  • 　Targeting RAGE: a viable strategy for cancer prevention and treatment? 　S Munesue, Y Yamamoto　IMARS Highlights　2017/11/26

show all

  • 　Monitoring of Heat Shock Response and Phenotypic Changes in Hepatocellular Carcinoma After Heat Treatment.　Zaimoku R, Miyashita T, Tajima H, Takamura H, Harashima AI, Munesue S, Yamamoto Y, Ninomiya I, Fushida S, Harada K.　Anticancer Res.　39　10　5393-5401　2019
  • 　In vitro anticancer effects of a RAGE inhibitor discovered using a structure-based drug design system　 Munesue S, El-Far AHAM, Harashima A, Sato A, Shindo M, Nakajima S, Inada M, Tanaka M, Takeuchi A, Tsuchiya H, Yamamoto H, Shaheen HME, El-Sayed YS, Kawano S, Tanuma SI, Yamamoto Y.　Oncol Lett　15　4627-4634　2018/04/15
  • 　Soluble Thrombomodulin Attenuates Endothelial Cell Damage in Hepatic Sinusoidal Obstruction Syndrome.　Takada S, Miyashita T, Yamamoto Y, Kanou S, Munesue S, Ohbatake Y, Nakanuma S, Okamoto K, Sakai S, Kinoshita J, Makino I, Nakamura K, Tajima H, Takamura H, Ninomiya I, Fushida S, Ohta T.　In Vivo.　32　6　1409-1417　2018
  • 　Contribution of methylglyoxal to delayed healing of bone injury in diabetes.　Aikawa T, Matsubara H, Ugaji S, Shirakawa J, Nagai R, Munesue S, Harashima A, Yamamoto Y, Tsuchiya H.　Mol Med Rep　16　1　403-409　2017
  • 　Anti-tumor effects of a nonsteroidal anti-inflammatory drug zaltoprofen on chondrosarcoma via activating peroxisome proliferator-activated receptor gamma and suppressing matrix metalloproteinase-2 expression.　Higuchi T, Takeuchi A, Munesue S, Yamamoto N, Hayashi K, Kimura H, Miwa S, Inatani H, Shimozaki S, Kato T, Aoki Y, Abe K, Taniguchi Y, Aiba H, Murakami H, Harashima A, Yamamoto Y, Tsuchiya H.　Cancer Med.　7　5　1944-1954　2018
  • 　Endogenous secretory receptor for advanced glycation end-products inhibits amyloid-beta1-42 uptake into mouse brain. 　J Alzheimer’s Dis　28　3　409-420　2012/11
  • 　Intestinal transepithelial permeability of oxytocin into the blood is dependent on the receptor for advanced glycation end products in mice.　Higashida H, Furuhara K, Yamauchi AM, Deguchi K, Harashima A, Munesue S, Lopatina O, Gerasimenko M, Salmina AB, Zhang JS, Kodama H, Kuroda H, Tsuji C, Suto S, Yamamoto H, Yamamoto Y.　Sci Rep.　7　1　7883　2017
  • 　Preventive Effect of Salicylate and Pyridoxamine on Diabetic Nephropathy. 　Abouzed TK, Munesue S, Harashima A, Masuo Y, Kato Y, Khailo K, Yamamoto H, Yamamoto Y.　J Diabetes Res.　1786789　2016
  • 　Tumor-associated macrophages of the M2 phenotype contribute to progression in gastric cancer with peritoneal dissemination.　Yamaguchi T, Fushida S, Yamamoto Y, Tsukada T, Kinoshita J, Oyama K, Miyashita T, Tajima H, Ninomiya I, Munesue S, Harashima A, Harada S, Yamamoto H, Ohta T.　Gastric Cancer　19 　1052-1065　2016
  • 　Induction of receptor for advanced glycation end-products by insufficient leptin action triggers pancreatic β-cell failure in type 2 diabetes.　Genes to Cells　2013/01
  • 　Low-molecular weight heparin suppresses RAGE-mediated expression of the malignant phenotype in human fibrosarcoma cells.　Cancer science　104　6　740-749　2013/06
  • 　Septic shock is associated with receptor for advanced glycation endproducts (RAGE) ligation of LPS.　JOURNAL OF IMMUNOLOGY　186　5　3248-3257　2011/01
  • 　Regulation of RAGE for Attenuating Progression of Diabetic Vascular Complications.　Exp Diabetes Res　2012/11
  • 　Maltitol endows foods with lower 3-deoxyglucosone content and less RAGE agonism as a sweetener against sucrose.　Kuretani A, Kawamura R, Munesue S, Yamamoto Y, Honda J, Yamamoto H. 　Glycative Stress Res,　1　25-31
  • 　cAMP ameliorates inflammation by modulation of macrophage receptor for advanced glycation end-products.　Motoyoshi S, Yamamoto Y, Munesue S, Igawa H, Harashima A, Saito H, Han D, Watanabe T, Sato H, Yamamoto H.　Biochem J　463　75-82 　2014
  • 　Septic Shock Is Associated with Receptor for Advanced Glycation End Products Ligation of LPS　Yamamoto, Yasuhiko;Harashima, Ai;Saito, Hidehito;Tsuneyama, Koichi;Munesue, Seiichi;Motoyoshi, So;Han, Dong;Watanabe, Takuo;Asano, Masahide;Takasawa, Shin;Okamoto, Hiroshi;Shimura, Satoshi;Karasawa, Tadahiro;Yonekura, Hideto;Yamamoto, Hiroshi　JOURNAL OF IMMUNOLOGY　186　5　3248-3257　2011
  • 　Pancreatic beta cell dysfunction in diabetes through induction of RAGE expression　Han, Dong;Yamamoto, Yasuhiko;Munesue, Seiichi;Motoyoshi, Soh;Saito, Hidehito;Watanabe, Takuo;Yamamoto, Hiroshi　AMINO ACIDS　41　0　S31-S31　2011
  • 　Inhibitory effects of food-derived components on AGE-RAGE signaling　Munesue, Seiichi;Yamamoto, Yasuhiko;Motoyoshi, So;Hidehito, Saito;Watanabe, Takuo;Yamamoto, Hiroshi　AMINO ACIDS　41　0　S55-S55　2011
  • 　Inhibition of Allergic Bronchial Asthma by Thrombomodulin Is Mediated by Dendritic Cells　Takagi, Takehiro;Taguchi, Osamu;Toda, Masaaki;Ruiz, Daniel Boveda;Bernabe, Paloma Gil;D'Alessandro-Gabazza, Corina N.;Miyake, Yasushi;Kobayashi, Tetsu;Aoki, Shinya;Chiba, Fumiko;Yano, Yutaka;Conway, Edward M.;Munesue, Seiichi;Yamamoto, Yasuhiko;Yamamoto, Hiroshi;Suzuki, Koji;Takei, Yoshiyuki;Morser, John;Gabazza, Esteban C.　AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE　183　1　31-42　2011
  • 　Sivelestat sodium hydrate inhibits neutrophil migration to the vessel wall and suppresses hepatic ischemia-reperfusion injury　Sakai, Seisho; Tajima, Hidehiro; Miyashita, Tomoharu; Nakanuma, Shinichi Ichi; Makino, Isamu; Hayashi, Hironori; Nakagawara, Hisatoshi; Kitagawa, Hirohisa; Fushida, Sachio; Fujimura, Takashi; Saito, Hidehito; Munesue, Seiichi; Yamamoto, Yasuhiko; Ohta, Tetsuo　Digestive Diseases and Sciences　59　4　787-794　2014/01/01　
  • 　Induction of receptor for advanced glycation end products by insufficient leptin action triggers pancreatic β-cell failure in type 2 diabetes　Han, Dong; Yamamoto, Yasuhiko; Munesue, Seiichi; Motoyoshi, So; Saito, Hidehito; Win, Myat Thu Thu; Watanabe, Takuo; Tsuneyama, Koichi; Yamamoto, Hiroshi　Genes to Cells　18　4　302-314　2013/04/01　
  • 　Validated liquid culture monitoring system for lifespan extension of Caenorhabditis elegans through genetic and dietary manipulations　Win, Myat Thu Thu; Yamamoto, Yasuhiko; Munesue, Seiichi; Han, Dong; Harada, Shinichi; Yamamoto, Hiroshi　Aging and Disease　4　4　178-185　2013/01/01　
  • 　Thrombomodulin modulates dendritic cells via both antagonism of high mobility group protein B1 and an independent mechanism　Toda, Masaaki; D'Alessandro-Gabazza, Corina Nayade; Takagi, Takehiro; Chelakkot-Govindalayathila, Ayshwarya Lakshmi; Taguchi, Osamu; Roeen, Ziaurahman; Munesue, Seiichi; Yamamoto, Yasuhiko; Yamamoto, Hiroshi; Gabazza, Esteban Cesar; Morser, John　Allergology International　63　1　57-66　2014/03/17　
  • 　Low-molecular weight fractions of Japanese soy sauce act as a RAGE antagonist via inhibition of RAGE trafficking to lipid rafts　Munesue, Seiichi; Yamamoto, Yasuhiko; Urushihara, Ryouta; Inomata, Kouhei; Saito, Hidehito; Motoyoshi, So; Watanabe, Takuo; Yonekura, Hideto; Yamamoto, Hiroshi　Food and Function　4　12　1835-1842　2013/12/01　
  • 　Regulation of RAGE for attenuating progression of diabetic vascular complications　Win, Myat Thu Thu; Yamamoto, Yasuhiko; Munesue, Seiichi; Saito, Hidehito; Han, Dong; Motoyoshi, So; Kamal, Tarek; Ohara, Takuro; Watanabe, Takuo; Yamamoto, Hiroshi　Experimental Diabetes Research　2012　2012/01/03　
  • 　Low molecular weight heparin suppresses receptor for advanced glycation end products-mediated expression of malignant phenotype in human fibrosarcoma cells　Takeuchi, Akihiko; Yamamoto, Yasuhiko; Munesue, Seiichi; Harashima, Ai; Watanabe, Takuo; Yonekura, Hideto; Yamamoto, Hiroshi; Tsuchiya, Hiroyuki　Cancer Science　104　6　740-749　2013/06/01　
  • 　RAGE mediates vascular injury and inflammation after global cerebral ischemia　Kamide, Tomoya; Kitao, Yasuko; Takeichi, Toshiaki; Okada, Akiko; Mohri, Hiromi; Schmidt, Ann Marie; Kawano, Takayuki; Munesue, Seiichi; Yamamoto, Yasuhiko; Yamamoto, Hiroshi; Hamada, Junichiro; Hori, Osamu　Neurochemistry International　60　3　220-228　2012/02/01　
  • 　RAGE signaling antagonist suppresses mouse macrophage foam cell formation.　Nontaphat Leerach,Seiichi Munesue,Ai Harashima,Kumi Kimura,Yu Oshima,Shuhei Kawano,Mariko Tanaka,Akane Niimura,Natthiya Sakulsak,Hiroshi Yamamoto,Osamu Hori,Yasuhiko Yamamoto　Biochemical and biophysical research communications　555　74　2021/05/28
  • 　Receptor for advanced glycation end-products (RAGE) plays a critical role in retrieval behavior of mother mice at early postpartum.　Maria Gerasimenko,Olga Lopatina,Seiichi Munesue,Ai Harashima,Shigeru Yokoyama,Yasuhiko Yamamoto,Haruhiro Higashida　Physiology & behavior　235　113395　2021/06/01
  • 　Glycation reaction and the role of the receptor for advanced glycation end-products in immunity and social behavior.　Nontaphat Leerach,Ai Harashima,Seiichi Munesue,Kumi Kimura,Yu Oshima,Hisanori Goto,Hiroshi Yamamoto,Haruhiro Higashida,Yasuhiko Yamamoto　Glycoconjugate journal　38　3　303　2021/06
  • 　Dynamic switch of immunity and antitumor effects of metformin in rat spontaneous esophageal carcinogenesis.　Ryohei Takei,Tomoharu Miyashita,Satoshi Takada,Hidehiro Tajima,Itasu Ninomiya,Hiroyuki Takamura,Sachio Fushida,Ai Harashima,Seiichi Munesue,Shintaro Yagi,Noriyuki Inaki,Tetsuo Ohta,Yasuhiko Yamamoto　Cancer immunology, immunotherapy : CII　71　4　777　2021/08/16
  • 　Dual Nature of RAGE in Host Reaction and Nurturing the Mother-Infant Bond.　Yu Oshima,Ai Harashima,Seiichi Munesue,Kumi Kimura,Nontaphat Leerach,Hisanori Goto,Mariko Tanaka,Akane Niimura,Kenjiro Hayashi,Hiroshi Yamamoto,Haruhiro Higashida,Yasuhiko Yamamoto　International journal of molecular sciences　23　4　2022/02/14
  • 　Hypoxia-Induced CD36 Expression in Gastric Cancer Cells Promotes Peritoneal Metastasis via Fatty Acid Uptake.　Tatsuya Aoki,Jun Kinoshita,Seiichi Munesue,Toshihide Hamabe-Horiike,Takahisa Yamaguchi,Yusuke Nakamura,Koichi Okamoto,Hideki Moriyama,Keishi Nakamura,Shinichi Harada,Yasuhiko Yamamoto,Noriyuki Inaki,Sachio Fushida　Annals of surgical oncology　2022/08/30
  • 　Use of Cocultures to Measure the Blood-Brain Barrier Permeability of Oxytocin.　Yasuhiko Yamamoto,Ai Harashima,Sei-Ichi Munesue,Haruhiro Higashida　Methods in molecular biology (Clifton, N.J.)　2384　247　2022
  • 　Soluble receptor for advanced glycation end products protects from ischemia- and reperfusion-induced acute kidney injury.　Taro Miyagawa,Yasunori Iwata,Megumi Oshima,Hisayuki Ogura,Koichi Sato,Shiori Nakagawa,Yuta Yamamura,Yasutaka Kamikawa,Taito Miyake,Shinji Kitajima,Tadashi Toyama,Akinori Hara,Norihiko Sakai,Miho Shimizu,Kengo Furuichi,Seiichi Munesue,Yasuhiko Yamamoto,Shuichi Kaneko,Takashi Wada　Biology open　11　1　2022/01/15
  • 　Inhibitory Effects of Saururus chinensis Extract on Receptor for Advanced Glycation End-Products-Dependent Inflammation and Diabetes-Induced Dysregulation of Vasodilation.　Kenjiro Hayashi,Koichi Sato,Seishi Ochi,Shuhei Kawano,Seiichi Munesue,Ai Harashima,Yu Oshima,Kumi Kimura,Takashi Kyoi,Yasuhiko Yamamoto　International journal of molecular sciences　23　10　2022/05/20
  • 　Thrombopoietin accumulation in hepatocytes induces a decrease in its serum levels in a sinusoidal obstruction syndrome model.　Hiroto Yamazaki,Hidehiro Tajima,Yasuhiko Yamamoto,Seiichi Munesue,Mitsuyoshi Okazaki,Yoshinao Ohbatake,Shinichi Nakanuma,Isamu Makino,Tomoharu Miyashita,Hiroyuki Takamura,Tetsuo Ohta　Molecular medicine reports　25　6　2022/06
  • 　Cilostazol improves the prognosis after hepatectomy in rats with sinusoidal obstruction syndrome.　Hiroaki Sugita,Shinichi Nakanuma,Seiichi Munesue,Tatsuya Ishikawa,Tomokazu Tokoro,Ryohei Takei,Mitsuyoshi Okazaki,Kaichiro Kato,Satoshi Takada,Isamu Makino,Noriyuki Ozaki,Yasuhiko Yamamoto,Shintaro Yagi　Journal of gastroenterology and hepatology　2024/02/13
  • 　ASO Visual Abstract: Hypoxia-Induced CD36 Expression in Gastric Cancer Cells Promotes Peritoneal Metastasis via Fatty Acid Uptake.　Tatsuya Aoki,Jun Kinoshita,Seiichi Munesue,Toshihide Hamabe-Horiike,Takahisa Yamaguchi,Yusuke Nakamura,Koichi Okamoto,Hideki Moriyama,Keishi Nakamura,Shinichi Harada,Yasuhiko Yamamoto,Noriyuki Inaki,Sachio Fushida　Annals of surgical oncology　2023/02/15
  • 　Assaying ADAMTS13 Activity as a Potential Prognostic Biomarker for Sinusoidal Obstruction Syndrome in Mice.　Masakazu Saeki,Seiichi Munesue,Yuri Higashi,Ai Harashima,Ryohei Takei,Satoshi Takada,Shinichi Nakanuma,Tetsuo Ohta,Shintaro Yagi,Hidehiro Tajima,Yasuhiko Yamamoto　International journal of molecular sciences　24　22　2023/11/15
  • 　Oxytocin Dynamics in the Body and Brain Regulated by the Receptor for Advanced Glycation End-Products, CD38, CD157, and Nicotinamide Riboside　Haruhiro Higashida,Kazumi Furuhara,Olga Lopatina,Maria Gerasimenko,Osamu Hori,Tsuyoshi Hattori,Yasuhiko Hayashi,Stanislav M. Cherepanov,Anna A. Shabalova,Alla B. Salmina,Kana Minami,Teruko Yuhi,Chiharu Tsuji,PinYue Fu,Zhongyu Liu,Shuxin Luo,Anpei Zhang,Shigeru Yokoyama,Satoshi Shuto,Mizuki Watanabe,Koichi Fujiwara,Sei-ichi Munesue,Ai Harashima,Yasuhiko Yamamoto　Frontiers in Neuroscience　16　2022/07/07　
  • 　Correction to: Dynamic switch of immunity and antitumor effects of metformin in rat spontaneous esophageal carcinogenesis.　Ryohei Takei,Tomoharu Miyashita,Satoshi Takada,Hidehiro Tajima,Itasu Ninomiya,Hiroyuki Takamura,Sachio Fushida,Ai Harashima,Seiichi Munesue,Shintaro Yagi,Noriyuki Inaki,Tetsuo Ohta,Yasuhiko Yamamoto　Cancer immunology, immunotherapy : CII　71　4　791　2021/09/07
  • 　A nonsteroidal anti-inflammatory drug, zaltoprofen, inhibits the growth of extraskeletal chondrosarcoma cells by inducing PPARγ, p21, p27, and p53　Takashi Higuchi,Akihiko Takeuchi,Seiichi Munesue,Norio Yamamoto,Katsuhiro Hayashi,Ai Harashima,Yasuhiko Yamamoto,Hiroyuki Tsuchiya　Cell Cycle　22　8　1　2023/01/12　

Conference Presentations

  • Molecular identification of RAGE-mediated tumor malignancy in human osteosarcoma HOS cells.(2023/10/12)
  • In vitro anticancer effects of a novel RAGE inhibitor on suppression of tumor malignant phenotypes in human fibrosarcoma cells(conference：13th International​ Symposium on the Maillard Reaction)(2018/09/10)
  • Drug library screening to identify new compounds for inducing ectodomain shedding of RAGE and formation of soluble RAGE(conference：13th International​ Symposium on the Maillard Reaction)(2018/09/10)
  • Preventive effects of salicylate and pyridoxamine on the development of diabetic kidney injuries.(2017/12/06)
  • In vitro effects of a novel RAGE inhibitor on tumor malignancy in human fibrosarcoma HT1080 cells(2017/12/06)

show all

  • Neuroprotective effects of endogenous secretory rage in ischemic cerebrovasculr diseases.(conference：12th International Symposium on the Maillard Reaction )(2015/09)
  • Insufficient leptin action induces RAGE expression and triggers pancreatic beta-cell failure type 2 diabetes. (conference：12th International Symposium on the Maillard Reaction )(2015/09)
  • Absence of mature adipocytes and adipocyte precursor cells in mesentery of Suncus murinus.(conference：American Diabetes Association 73rd scientific session)(2013/06)

Others

  • 　Zaltoprofenはin vitroとin vivoにおいてPPARγを介して軟骨肉腫の増殖を抑制する　樋口 貴史,山本 憲男,林 克洋,武内 章彦,阿部 健作,谷口 裕太,原島 愛,棟居 聖一,山本 靖彦,土屋 弘行　日本整形外科学会雑誌　91　8　S1527　2017/08
  • 　軟骨肉腫に対するzaltoprofenのPPARγ(peroxisome proliferator-activated receptor γ)を介した抗腫瘍効果の解析　樋口 貴史,山本 憲男,林 克洋,武内 章彦,阿部 健作,谷口 裕太,相羽 久輝,村上 英樹,棟居 聖一,山本 靖彦,土屋 弘行　日本整形外科学会雑誌　91　6　S1393　2017/06
  • 　骨軟部 化学療法・有害事象の現況 軟骨肉腫においてzaltoprofenはPPARγを介して抗腫瘍効果を発揮する　樋口 貴史,武内 章彦,山本 憲男,林 克洋,阿部 健作,谷口 裕太,相羽 久輝,棟居 聖一,山本 靖彦,土屋 弘行　日本癌治療学会学術集会抄録集　54回　WS31　2016/10
  • 　糖尿病による骨修復能障害はピリドキサミン投与により改善される　宇賀治 修平,松原 秀憲,相川 敬男,吉田 泰久,棟居 聖一,原島 愛,山本 靖彦,土屋 弘行　日本整形外科学会雑誌　91　8　S1703　2017/08
  • 　ZaltoprofenはPPARγを介して軟骨肉腫の増殖を抑制する　樋口 貴史,山本 憲男,林 克洋,武内 章彦,阿部 健作,谷口 裕太,相羽 久輝,荒木 麗博,原島 愛,棟居 聖一,山本 靖彦,土屋 弘行　日本癌治療学会学術集会抄録集　55回　P41　2017/10

show all

  • 　ZaltoprofenはPPARγ(peroxisome proliferator-activated receptor γ)を介して軟骨肉腫における浸潤能および遊走能の抑制効果を発揮する　樋口 貴史,武内 章彦,山本 憲男,林 克洋,三輪 真嗣,稲谷 弘幸,阿部 健作,谷口 裕太,棟居 聖一,山本 靖彦,土屋 弘行　日本整形外科学会雑誌　90　8　S1556　2016/08
  • 　整形トピックス ザルトプロフェンはPPARγを介して軟骨肉腫における浸潤能および遊走能の抑制効果を発揮する　樋口 貴史,武内 章彦,土屋 弘行,山本 靖彦,棟居 聖一　整形外科　68　10　1082　2017/09

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「RAGE膜貫通ドメインと結合する分子の発見とがん細胞悪性化機構の解明」(2023-2025)　
○「バイオプリンティング技術を用いた新規3次元皮膚モデル作製への挑戦」(2023-2025)　
○「愛情ホルモン・オキシトシンによる炎症免疫抑制作用の分子基盤の解明」(2021-2023)　
○「RAGE膜貫通ドメインによる細胞膜ダイナミクスとがん悪性化シグナルの解明」(2020-2022)　
○「オキシトシンの血液脳関門移行に関わる分子装置の解明と愛情の構築研究」(2018-2020)　
○「Glyoxalase2遺伝子多型に基づく統合失調症の病態解明と新規治療薬の創出」(2018-2020)　
○「食品に含まれるRAGEシグナル阻害成分の同定と阻害機構の解明」(2014-2016)
○「新規内在性デコイ受容体ｅｓＲＡＧＥに着目したアルツハイマー病予防・治療法の開発」
○「新規内在性デコイ受容体に着目したアルツハイマー病の病因・制御の解明」

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

○Introduction to Region-studies(2022)
○Basic Medical and Pharmaceutical Sciences Rotation Practice（Course in Biomedical Science）ⅠＡ(2022)
○Biochemistry 2(2022)
○Biochemistry 4(2022)
○Basic Medical and Pharmaceutical Sciences Rotation Practice（Course in Biomedical Science）ⅠＡ(2022)
○Basic Medical and Pharmaceutical Sciences Rotation Practice（Course in Biomedical Science）ⅠＡ(2022)
○Academic Skills(2022)
○Basic Biological Chemistry(2022)
○Biochemistry 2(2022)
○Basic Medical and Pharmaceutical Sciences Rotation Practice（Course in Biomedical Science）ⅠＡ(2022)
○Introduction to Region-studies(2021)
○Academic Skills(2021)
○Biochemistry 2(2020)
○Biochemistry2(2019)
○Biochemistry2(2017)
○Biochemistry2(2017)

Classes (Graduate Schools)

○Molecular Biology of the Cardiovascular System(2020)
○Molecular Biology of the Cardiovascular System(2020)
○Molecular Biology of the Cardiovascular System(2019)
○Molecular Biology of the Cardiovascular System(2019)
○Molecular Biology of the Cardiovascular System(2018)
○Molecular Biology of the Cardiovascular System(2018)
○Molecular Biology of the Cardiovascular System(2017)
○Molecular Biology of the Cardiovascular System(2017)

International Project

International Students

Lecture themes

Others (Social Activities)

To Page Top