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Researcher Information

last modified：2024/11/21

Professor　TAKAMURA Toshinari

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Faculty, Affiliation

Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences　Department of Endocrinology and Metabolism
Professor

College and School Educational Field

Division of Medical Sciences, Graduate School of Medical Science
Division of Medicine, Graduate School of Medical Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences

Laboratory

Department of Endocrinology and Metabolism　TEL:076-265-2711　FAX:076-234-4214

Academic Background

【Academic background(Doctoral/Master's Degree)】
Kanazawa University Graduate School of Medical Sciences　Doctor　Kanazawa University Graduate School of Medical Sciences　Internal Medicine　199207　Completed
【Academic background(Bachelor's Degree)】
Kanazawa University　1988

Career

Tohoku University　Department of Biochemistry(1993/04/01-1997/08/31)
Kanazawa University Graduate School of Medical Sciences　Department of Endocrinology and Metabolism　Professor(2014/03/01-)
Kanazawa University Graduate School of Medical Sciences　Department of Disease and Homeostasis　Associate Professor(2005/04/01-2014/02/28)

Year & Month of Birth

1963/04

Academic Society


Japan Diabetes Society
Japan Endocrine Society


Japan Society of Experimental Diabetes and Obesity
The Japanese Society of Clinical Nutrition

Asian Association for the Study of Diabetes

Award




○Award in Third JSH Single Topic Conference(2004/10/08)
○Award in Third JSH Single Topic Conference(2004/10/08)
○Award in Third JSH Single Topic Conference(2004/10/08)
○Award in Third JSH Single Topic Conference(2004/10/08)
○Award in Third JSH Single Topic Conference(2004/10/08)
○Award in Third JSH Single Topic Conference(2004/10/08)

Specialities

Metabolomics、Endocrinology、Pathological medical chemistry

Speciality Keywords

Diabetology, Endocrinology and Metabolism

Research Themes

Pathology of type 2 diabetes

Pathology of fatty liver and obesity

Books

  • 　Takamura T*, Misu H, Kaneko S.　Musculoskeletal Disease Associated with Diabetes Mellitus　Springer Tokyo Heidelberg New York Dordrecht London　2016
  • 　Molecular Diabetology 2005-from basic to clinic-　2005/04
  • 　Yoshizawa M,Takamura T,Kobayashi K　[Soluble VCAM-1].　60 Suppl 8　498-503
  • 　Shuichi Kaneko, Toshinari Takamura, Hirofumi Misu　Non-Alcoholic Fatty Liver Diseases　Wiley　2019

Papers

  • 　Selenoprotein P as a diabetes-associated hepatokine that impairs angiogenesis by inducing VEGF resistance in vascular endothelial cells.　Ishikura K,Misu H,Kumazaki M,Takayama H,Matsuzawa-Nagata N,Tajima N,Chikamoto K,Lan F,Ando H,Ota T,Sakurai M,Takeshita Y,Kato K,Fujimura A,Miyamoto KI,Saito Y,Kameo S,Okamoto Y,Takuwa Y,Takahashi K,Kidoya H,Takakura N,Kaneko S,Takamura T　DIABETOLOGIA　2014/09
  • 　LECT2 functions as a hepatokine that links obesity to skeletal muscle insulin resistance.　Lan F,Misu H,Chikamoto K,Takayama H,Kikuchi A,Mohri K,Takata N,Hayashi H,Matsuzawa-Nagata N,Takeshita Y,Noda H,Matsumoto Y,Ota T,Nagano T,Nakagen M,Miyamoto K,Takatsuki K,Seo T,Iwayama K,Tokuyama K,Matsugo S,Tang H,Saito Y,Yamagoe S,Kaneko S,Takamura T　DIABETES　63　5　1649-64　2014/05
  • 　Proteasome dysfunction mediates obesity-induced endoplasmic reticulum stress and insulin resistance in the liver.　Otoda T,Takamura T,Misu H,Ota T,Murata S,Hayashi H,Takayama H,Kikuchi A,Kanamori T,Shima KR,Lan F,Takeda T,Kurita S,Ishikura K,Kita Y,Iwayama K,Kato K,Uno M,Takeshita Y,Yamamoto M,Tokuyama K,Iseki S,Tanaka K,Kaneko S　DIABETES　62　3　811-24　2013/03
  • 　A liver-derived secretory protein, selenoprotein P, causes insulin resistance.　Misu H,Takamura T,Takayama H,Hayashi H,Matsuzawa-Nagata N,Kurita S,Ishikura K,Ando H,Takeshita Y,Ota T,Sakurai M,Yamashita T,Mizukoshi E,Yamashita T,Honda M,Miyamoto K,Kubota T,Kubota N,Kadowaki T,Kim HJ,Lee IK,Minokoshi Y,Saito Y,Takahashi K,Yamada Y,Takakura N,Kaneko S　Cell Metab　12　5　483-95　2010/11
  • 　Metformin suppresses expression of the selenoprotein P gene via an AMP-activated kinase (AMPK)/FoxO3a pathway in H4IIEC3 hepatocytes.　Takayama H,Misu H,Iwama H,Chikamoto K,Saito Y,Murao K,Teraguchi A,Lan F,Kikuchi A,Saito R,Tajima N,Shirasaki T,Matsugo S,Miyamoto K,Kaneko S,Takamura T　J Biol Chem　289　1　335-45　2014/01

show all

  • 　Long-term outcomes of Japanese type 2 diabetic patients with biopsy-proven diabetic nephropathy.　Shimizu M,Furuichi K,Toyama T,Kitajima S,Hara A,Kitagawa K,Iwata Y,Sakai N,Takamura T,Yoshimura M,Yokoyama H,Kaneko S,Wada T,Kanazawa Study Group for Renal Diseases and Hypertension　DIABETES CARE　36　11　3655-62　2013/11
  • 　ER stress induced impaired TLR signaling and macrophage differentiation of human monocytes.　Komura T,Sakai Y,Honda M,Takamura T,Wada T,Kaneko S　Cell Immunol　282　1　44-52　2013/03
  • 　Sugar-sweetened beverage and diet soda consumption and the 7-year risk for type 2 diabetes mellitus in middle-aged Japanese men.　Sakurai M,Nakamura K,Miura K,Takamura T,Yoshita K,Nagasawa SY,Morikawa Y,Ishizaki M,Kido T,Naruse Y,Suwazono Y,Sasaki S,Nakagawa H　Eur J Nutr　53　1　251-8　2014/06
  • 　Adipose tissue-derived stem cells as a regenerative therapy for a mouse steatohepatitis-induced cirrhosis model.　Seki A,Sakai Y,Komura T,Nasti A,Yoshida K,Higashimoto M,Honda M,Usui S,Takamura M,Takamura T,Ochiya T,Furuichi K,Wada T,Kaneko S　HEPATOLOGY　58　3　1133-42　2013/09
  • 　Regulation of the physiological effects of peroxidovanadium(V) complexes by the electronic nature of ligands.　Sugiyama H,Matsugo S,Misu H,Takamura T,Kaneko S,Kanatani Y,Kaido M,Mihara C,Abeywardana N,Sakai A,Sato K,Miyashita Y,Kanamori K　J Inorg Biochem　121　66-76　2013/04
  • 　Dosing time-dependent effect of raloxifene on plasma plasminogen activator inhibitor-1 concentrations in post-menopausal women with osteoporosis.　Ando H,Otoda T,Ookami H,Nagai Y,Inano A,Takamura T,Ushijima K,Hosohata K,Matsushita E,Saito T,Kaneko S,Fujimura A　Clin Exp Pharmacol Physiol　40　3　227-32　2013/03
  • 　Clinicopathological features of liver injury in patients with type 2 diabetes mellitus and comparative study of histologically proven nonalcoholic fatty liver diseases with or without type 2 diabetes mellitus.　Shima T,Uto H,Ueki K,Takamura T,Kohgo Y,Kawata S,Yasui K,Park H,Nakamura N,Nakatou T,Tanaka N,Umemura A,Mizuno M,Tanaka J,Okanoue T　J Gastroenterol　48　4　515-25　2013/04
  • 　Quantitative analysis of hepatic fat fraction by single-breath-holding MR spectroscopy with T₂ correction: phantom and clinical study with histologic assessment.　Hayashi N,Miyati T,Minami T,Takeshita Y,Ryu Y,Matsuda T,Ohno N,Hamaguchi T,Kato K,Takamura T,Matsui O　Radiol Phys Technol　6　1　219-25　2013/01
  • 　Ectopic fat accumulation and distant organ-specific insulin resistance in Japanese people with nonalcoholic fatty liver disease.　Kato K,Takamura T,Takeshita Y,Ryu Y,Misu H,Ota T,Tokuyama K,Nagasaka S,Matsuhisa M,Matsui O,Kaneko S　PLoS One　9　3　e92170　2014/03
  • 　Urinary Kim-1 is a sensitive biomarker for the early stage of diabetic nephropathy in Otsuka Long-Evans Tokushima Fatty rats.　Hosohata K,Ando H,Takeshita Y,Misu H,Takamura T,Kaneko S,Fujimura A　Diab Vasc Dis Res　11　4　243-250　2014/05
  • 　Association between a serum thyroid-stimulating hormone concentration within the normal range and indices of obesity in Japanese men and women.　Sakurai M,Nakamura K,Miura K,Yoshita K,Takamura T,Nagasawa SY,Morikawa Y,Ishizaki M,Kido T,Naruse Y,Nakashima M,Nogawa K,Suwazono Y,Nakagawa H　Intern Med　53　7　669-74　2014
  • 　The effects of ezetimibe on non-alcoholic fatty liver disease and glucose metabolism: a randomised controlled trial.　Takeshita Y,Takamura T,Honda M,Kita Y,Zen Y,Kato K,Misu H,Ota T,Nakamura M,Yamada K,Sunagozaka H,Arai K,Yamashita T,Mizukoshi E,Kaneko S　DIABETOLOGIA　57　5　878-90　2014/05
  • 　Genetic variants in selenoprotein P plasma 1 gene (SEPP1) are associated with fasting insulin and first phase insulin response in Hispanics.　Hellwege JN,Palmer ND,Ziegler JT,Langefeld CD,Lorenzo C,Norris JM,Takamura T,Bowden DW　GENE　534　1　33-9　2014/01
  • 　Sugar-sweetened beverage and diet soda consumption and the 7-year risk for type 2 diabetes mellitus in middle-aged Japanese men.　Sakurai M,Nakamura K,Miura K,Takamura T,Yoshita K,Nagasawa SY,Morikawa Y,Ishizaki M,Kido T,Naruse Y,Suwazono Y,Sasaki S,Nakagawa H　Eur J Nutr　53　1　251-8　2014/06
  • 　Cyclosporine A inhibits the secretion of certain anterior pituitary hormones in patients with nephrotic syndrome.　Nagai Y,Miyakoshi H,Ohsawa K,Ieki Y,Takamura T,Kobayashi K　Endocrinol Jpn　39　1　129-32　1992/02
  • 　Regulatory role of CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) in insulin secretion by glucose in pancreatic beta cells. Enhanced insulin secretion in CD38-expressing transgenic mice.　Kato I,Takasawa S,Akabane A,Tanaka O,Abe H,Takamura T,Suzuki Y,Nata K,Yonekura H,Yoshimoto T　J Biol Chem　270　50　30045-50　1995/12
  • 　The structure of the Aplysia kurodai gene encoding ADP-ribosyl cyclase, a second-messenger enzyme.　Nata K,Sugimoto T,Tohgo A,Takamura T,Noguchi N,Matsuoka A,Numakunai T,Shikama K,Yonekura H,Takasawa S　GENE　158　2　213-8　1995/06
  • 　An adult case of neurohypophyseal ectopy presenting ACTH deficiency and partial GH deficiency.　Takamura T,Ohsawa K,Nishimura Y,Yamagishi S,Komatsu Y,Iwata A,Osada S,Nagai Y,Miyakoshi H,Kobayashi K　Endocr J　42　1　83-8　1995/02
  • 　Assignment of CD38, the gene encoding human leukocyte antigen CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase), to chromosome 4p15.　Nakagawara K,Mori M,Takasawa S,Nata K,Takamura T,Berlova A,Tohgo A,Karasawa T,Yonekura H,Takeuchi T　Cytogenet Cell Genet　69　1-2　38-9　1995
  • 　Inhibitory effect of cyclosporin A on prolactin synthesis in GH3 cells.　Nagai Y,Ohsawa K,Ohta M,Hisada A,Yamashita H,Yoshizawa M,Yamamoto Y,Takamura T,Kobayashi K　Tohoku J Exp Med　180　4　337-46　1996/12
  • 　Human gene encoding CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase): organization, nucleotide sequence and alternative splicing.　Nata K,Takamura T,Karasawa T,Kumagai T,Hashioka W,Tohgo A,Yonekura H,Takasawa S,Nakamura S,Okamoto H　GENE　186　2　285-92　1997/02
  • 　Elevated serum levels of soluble vascular cell adhesion molecule-1 in NIDDM patients with proliferative diabetic retinopathy.　Yoshizawa M,Nagai Y,Ohsawa K,Ohta M,Yamashita H,Hisada A,Miyamoto I,Miura K,Takamura T,Kobayashi K　Diabetes Res Clin Pract　42　1　65-70　1998/10
  • 　Antibodies to GAD in diabetic patients with chronic hepatitis C.　Ando H,Nagai Y,Yokoyama M,Takamura T,Kobayashi K　Diabet Med　15　9　797　1998/09
  • 　Amyloid goiter presented as a subacute thyroiditis-like symptom in a patient with hypersensitivity vasculitis.　Nagai Y,Ohta M,Yokoyama H,Takamura T,Kobayashi KI　Endocr J　45　3　421-5　1998/06
  • 　Transgenic mice overexpressing type 2 nitric-oxide synthase in pancreatic beta cells develop insulin-dependent diabetes without insulitis.　Takamura T,Kato I,Kimura N,Nakazawa T,Yonekura H,Takasawa S,Okamoto H　J Biol Chem　273　5　2493-6　1998/01
  • 　A patient with GH-producing pituitary adenoma presenting with a binasal superior quadrantanopsia.　Nagai Y,Takamura T,Ando H,Nohara E,Yamashita H,Ieki Y,Takazakura E,Kobayashi K　Endocr J　46　2　345-6　1999/04
  • 　Serum soluble adhesion molecule concentrations are not regulated by acute hyperinsulinaemia in healthy men.　Nagai Y,Takamura T,Nohara E,Yamashita H,Kobayashi K　Diabet Med　16　7　618　1999/07
  • 　Acute hyperinsulinemia reduces plasma concentrations of homocysteine in healthy men.　Nagai Y,Takamura T,Nohara E,Yamashita H,Kobayashi K　DIABETES CARE　22　6　1004　1999/06
  • 　Variation of the fatty acid binding protein 2 gene is not associated with obesity and insulin resistance in Japanese subjects.　Hayakawa T,Nagai Y,Nohara E,Yamashita H,Takamura T,Abe T,Nomura G,Kobayashi K　Metabolism　48　5　655-7　1999/05
  • 　Phenotypic characterization of the beta3-adrenergic receptor mutation and the uncoupling protein 1 polymorphism in Japanese men.　Hayakawa T,Nagai Y,Taniguchi M,Yamashita H,Takamura T,Abe T,Nomura G,Kobayashi K　Metabolism　48　5　636-40　1999/05
  • 　Adrenal insufficiency due to metastatic hepatocellular carcinoma.　Takamura T,Nagai Y,Yamashita H,Nohara E,Ando H,Kagaya M,Urabe T,Kaneko S,Kobayashi K　Endocr J　46　4　591-6　1999/08
  • 　Pioglitazone prevents mice from multiple low-dose streptozotocin-induced insulitis and diabetes.　Takamura T,Ando H,Nagai Y,Yamashita H,Nohara E,Kobayashi K　Diabetes Res Clin Pract　44　2　107-14　1999/05
  • 　S20G mutation of the amylin gene in Japanese patients with type 2 diabetes.　Hayakawa T,Nagai Y,Ando H,Yamashita H,Takamura T,Abe T,Nomura G,Kobayashi KI　Diabetes Res Clin Pract　49　2-3　195-7　2000/08
  • 　Cerivastatin improves survival of mice with lipopolysaccharide-induced sepsis.　Ando H,Takamura T,Ota T,Nagai Y,Kobayashi K　J Pharmacol Exp Ther　294　3　1043-6　2000/09
  • 　Plasma levels of vascular endothelial growth factor in patients with acromegaly.　Nagai Y,Ando H,Nohara E,Yamashita H,Takamura T,Kobayashi K　Horm Metab Res　32　8　326-9　2000/08
  • 　Gln27Glu and Arg16Gly polymorphisms of the beta2-adrenergic receptor gene are not associated with obesity in Japanese men.　Hayakawa T,Nagai Y,Kahara T,Yamashita H,Takamura T,Abe T,Nomura G,Kobayashi K　Metabolism　49　9　1215-8　2000/09
  • 　Tumor necrosis factor-beta gene NcoI polymorphism decreases insulin resistance in Japanese men.　Hayakawa T,Nagai Y,Taniguchi M,Yamashita H,Takamura T,Abe T,Nomura G,Kobayashi K　Metabolism　49　11　1506-9　2000/11
  • 　Ischemic colitis probably induced by refractory constipation after voglibose administration in a patient with total gastrectomy.　Nagai Y,Yamashita H,Nohara E,Takamura T,Kobayashi K　Intern Med　39　10　861　2000/10
  • 　Ketosis-onset diabetes without islet-associated autoantibodies in a patient with MELAS.　Takamura T,Nagai Y,Torita M,Yamashita H,Kahara T,Koshino Y,Kobayashi K　DIABETES CARE　23　7　1018-9　2000/07
  • 　Inhibitory effect of troglitazone on TNF-alpha-induced expression of monocyte chemoattractant protein-1 (MCP-1) in human endothelial cells.　Ohta MY,Nagai Y,Takamura T,Nohara E,Kobayashi K　Diabetes Res Clin Pract　48　3　171-6　2000/06
  • 　Does acute hyperinsulinaemia change plasma adrenomedullin concentration in healthy men?　Nagai Y,Yamashita H,Takamura T,Kobayashi KI　Diabet Med　17　3　249-50　2000/03
  • 　Inhibitory effect of troglitazone on tumor necrosis factor alpha-induced expression of monocyte chemoattractant protein-1 in human mesangial cells.　Ohta MY,Nagai Y,Takamura T,Nohara E,Kobayashi K　Metabolism　49　2　163-6　2000/02
  • 　Extramedullary plasmacytoma in the adrenal incidentaloma.　Kahara T,Nagai Y,Yamashita H,Nohara E,Kobayashi K,Takamura T　Clin Endocrinol (Oxf)　55　2　267-70　2001/08
  • 　Stage-specific effects of a thiazolidinedione on proliferation, differentiation and PPARgamma mRNA expression in 3T3-L1 adipocytes.　Takamura T,Nohara E,Nagai Y,Kobayashi K　Eur J Pharmacol　422　1-3　23-9　2001/06
  • 　Severe hypercholesterolemia in a double heterozygote for lipoprotein lipase deficiency (LPL(Arita)) and apolipoprotein epsilon4: a report of a family with LPL(Arita).　Ando H,Nishimura Y,Nemoto T,Takamura T,Nagai Y,Kobayashi K　Endocr J　48　1　113-8　2001/02
  • 　A case of refractory hypothyroidism requiring daily intravenous thyroxine.　Nagaoka T,Miyakoshi H,Takamura T,Nagai Y,Matsushita S,Kaneko S,Kobayashi K　J Int Med Res　30　4　463-5　2002/07
  • 　Preobesity in World Health Organization classification involves the metabolic syndrome in Japanese.　Ota T,Takamura T,Hirai N,Kobayashi K　DIABETES CARE　25　7　1252-3　2002/07
  • 　Prediction of exercise-mediated changes in metabolic markers by gene polymorphism.　Kahara T,Takamura T,Hayakawa T,Nagai Y,Yamaguchi H,Katsuki T,Katsuki K,Katsuki M,Kobayashi K　Diabetes Res Clin Pract　57　2　105-10　2002/08
  • 　IL-6 gene polymorphism -174G/C does not contribute substantially to hyperlipidaemia and Type II diabetes mellitus in Japanese men.　Hayakawa T,Takamura T,Hisada A,Abe T,Nomura G,Kobayashi K　DIABETOLOGIA　45　3　453-4　2002/03
  • 　Thiazolidinedione derivatives ameliorate albuminuria in streptozotocin-induced diabetic spontaneous hypertensive rat.　Yamashita H,Nagai Y,Takamura T,Nohara E,Kobayashi K　Metabolism　51　4　403-8　2002/04
  • 　Does pravastatin affect circulating levels of soluble TNF receptor 2 in hypercholesterolemic patients?　Ando H,Takamura T,Kobayashi K,Misu H,Osawa K　ATHEROSCLEROSIS　166　2　413-4　2003/02
  • 　The transient appearance of anti-GAD antibody in a type 2 diabetic patient with empyema.　Kahara T,Takamura T,Ando H,Misaki T,Komori K,Ohya N,Kobayashi K　Intern Med　42　6　541-2　2003/06
  • 　Tumor necrosis factor-alpha and troglitazone regulate plasminogen activator inhibitor type 1 production through extracellular signal-regulated kinase- and nuclear factor-kappaB-dependent pathways in cultured human umbilical vein endothelial cells.　Hamaguchi E,Takamura T,Shimizu A,Nagai Y　J Pharmacol Exp Ther　307　3　987-94　2003/12
  • 　PPARgamma gene polymorphism is associated with exercise-mediated changes of insulin resistance in healthy men.　Kahara T,Takamura T,Hayakawa T,Nagai Y,Yamaguchi H,Katsuki T,Katsuki K,Katsuki M,Kobayashi K　Metabolism　52　2　209-12　2003/02
  • 　Preventive effect of cerivastatin on diabetic nephropathy through suppression of glomerular macrophage recruitment in a rat model.　Ota T,Takamura T,Ando H,Nohara E,Yamashita H,Kobayashi K　DIABETOLOGIA　46　6　843-51　2003/06
  • 　Fulminating onset type 1 diabetes with positivity for anti-GAD antibody and elevated pancreatic exocrine enzyme concentrations.　Kahara T,Takamura T,Ando H,Sakurai M,Ota T,Misaki T,Oba S,Iguchi M,Komori K,Kobayashi K　Intern Med　42　6　517-20　2003/06
  • 　Predictive value of autoantibodies to IA-2 for insulin requirements in Japanese subjects with type 1 diabetes.　Ota T,Takamura T,Bando Y,Usuda R,Nagai Y　DIABETES CARE　26　11　3188-9　2003/11
  • 　The specific p38 mitogen-activated protein kinase pathway inhibitor FR167653 keeps insulitis benign in nonobese diabetic mice.　Ando H,Kurita S,Takamura T　Life Sci　74　14　1817-27　2004/02
  • 　Modulating effects of olanzapine on the development of diabetic ketoacidosis.　Tsuchiyama N,Ando H,Ota T,Sakurai M,Takamura T　Diabet Med　21　3　300-1　2004/03
  • 　Prostaglandin E1 in lipid microspheres ameliorates diabetic peripheral neuropathy: clinical usefulness of Semmes-Weinstein monofilaments for evaluating diabetic sensory abnormality.　Akahori H,Takamura T,Hayakawa T,Ando H,Yamashita H,Kobayashi K　Diabetes Res Clin Pract　64　3　153-9　2004/06
  • 　Gln27Glu polymorphism of the beta2 adrenergic receptor gene in healthy Japanese men is associated with the change of fructosamine level caused by exercise.　Kahara T,Hayakawa T,Nagai Y,Shimizu A,Takamura T　Diabetes Res Clin Pract　64　3　207-12　2004/06
  • 　Effects of pravastatin on the expression of ATP-binding cassette transporter A1.　Ando H,Tsuruoka S,Yamamoto H,Takamura T,Kaneko S,Fujimura A　J Pharmacol Exp Ther　311　1　420-5　2004/10
  • 　Genes for systemic vascular complications are differentially expressed in the livers of type 2 diabetic patients.　Takamura T,Sakurai M,Ota T,Ando H,Honda M,Kaneko S　DIABETOLOGIA　47　4　638-47　2004/04
  • 　Significance of IA-2 antibody in Japanese type 1 diabetes: its association with GAD antibody.　Ota T,Takamura T,Nagai Y,Bando Y,Usuda R　Diabetes Res Clin Pract　67　1　63-9　2005/01
  • 　Regulation of cholesterol 7alpha-hydroxylase mRNA expression in C57BL/6 mice fed an atherogenic diet.　Ando H,Tsuruoka S,Yamamoto H,Takamura T,Kaneko S,Fujimura A　ATHEROSCLEROSIS　178　2　265-9　2005/02
  • 　Tranilast prevents the progression of experimental diabetic nephropathy through suppression of enhanced extracellular matrix gene expression.　Akahori H,Ota T,Torita M,Ando H,Kaneko S,Takamura T　J Pharmacol Exp Ther　314　2　514-21　2005/08
  • 　Relationship between plasma hANP level and pretibial edema by pioglitazone treatment.　Kahara T,Takamura T,Misaki T,Sakurai M,Takeshita Y,Shimizu A,Kaneko S　Endocr J　52　3　373-6　2005/06
  • 　Pancreatic exocrine and endocrine events occur concomitantly but independently during the course of fulminant type 1 diabetes.　Kahara T,Takamura T,Sakurai M,Misu H,Usuda R,Hayakawa T,Nishimura Y,Bando Y,Nagaoka T,Nagai Y,Kaneko S　Diabetes Res Clin Pract　71　3　241-6　2006/03
  • 　Daily rhythms of P-glycoprotein expression in mice.　Ando H,Yanagihara H,Sugimoto K,Hayashi Y,Tsuruoka S,Takamura T,Kaneko S,Fujimura A　Chronobiol Int　22　4　655-65　2005
  • 　cDNA microarray analysis of autoimmune hepatitis, primary biliary cirrhosis and consecutive disease manifestation.　Honda M,Kawai H,Shirota Y,Yamashita T,Takamura T,Kaneko S　J Autoimmun　25　2　133-40　2005/09
  • 　Rhythmic messenger ribonucleic acid expression of clock genes and adipocytokines in mouse visceral adipose tissue.　Ando H,Yanagihara H,Hayashi Y,Obi Y,Tsuruoka S,Takamura T,Kaneko S,Fujimura A　ENDOCRINOLOGY　146　12　5631-6　2005/12
  • 　Effects of grapefruit juice on the pharmacokinetics of pitavastatin and atorvastatin.　Ando H,Tsuruoka S,Yanagihara H,Sugimoto K,Miyata M,Yamazoe Y,Takamura T,Kaneko S,Fujimura A　Br J Clin Pharmacol　60　5　494-7　2005/11
  • 　Subacute thyroiditis developed in identical twins two years apart.　Hamaguchi E,Nishimura Y,Kaneko S,Takamura T　Endocr J　52　5　559-62　2005/10
  • 　Measurement of thyroid blood flow area is useful for diagnosing the cause of thyrotoxicosis.　Kurita S,Sakurai M,Kita Y,Ota T,Ando H,Kaneko S,Takamura T　THYROID　15　11　1249-52　2005/11
  • 　Pancreatic exocrine and endocrine events occur concomitantly but independently during the course of fulminant type 1 diabetes.　Kahara T,Takamura T,Sakurai M,Misu H,Usuda R,Hayakawa T,Nishimura Y,Bando Y,Nagaoka T,Nagai Y,Kaneko S　Diabetes Res Clin Pract　71　3　241-6　2006/03
  • 　Gender differences in the association between anthropometric indices of obesity and blood pressure in Japanese.　Sakurai M,Miura K,Takamura T,Ota T,Ishizaki M,Morikawa Y,Kido T,Naruse Y,Nakagawa H　Hypertens Res　29　2　75-80　2006/02
  • 　Profile of rhythmic gene expression in the livers of obese diabetic KK-A(y) mice.　Ando H,Oshima Y,Yanagihara H,Hayashi Y,Takamura T,Kaneko S,Fujimura A　Biochem Biophys Res Commun　346　4　1297-302　2006/08
  • 　Factors associated with improvement of fasting plasma glucose level by mealtime dosing of a rapid-acting insulin analog in type 2 diabetes.　Takamura T,Sakurai M,Nakamura M,Shimizu A,Ota T,Misu H,Takeshita Y,Tsuchiyama N,Kurita S,Ando H,Kaneko S　Diabetes Res Clin Pract　75　3　278-84　2007/03
  • 　Erythrocyte sorbitol level as a predictor of the efficacy of epalrestat treatment for diabetic peripheral polyneuropathy.　Ando H,Takamura T,Nagai Y,Kaneko S,Kanazawa University Multicenter Diabetes Study Group　J Diabetes Complications　20　6　367-70　2006/11
  • 　Genes involved in oxidative phosphorylation are coordinately upregulated with fasting hyperglycaemia in livers of patients with type 2 diabetes.　Misu H,Takamura T,Matsuzawa N,Shimizu A,Ota T,Sakurai M,Ando H,Arai K,Yamashita T,Honda M,Yamashita T,Kaneko S　DIABETOLOGIA　50　2　268-77　2007/02
  • 　Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis.　Ota T,Takamura T,Kurita S,Matsuzawa N,Kita Y,Uno M,Akahori H,Misu H,Sakurai M,Zen Y,Nakanuma Y,Kaneko S　GASTROENTEROLOGY　132　1　282-93　2007/01
  • 　Liver steatosis, but not fibrosis, is associated with insulin resistance in nonalcoholic fatty liver disease.　Sakurai M,Takamura T,Ota T,Ando H,Akahori H,Kaji K,Sasaki M,Nakanuma Y,Miura K,Kaneko S　J Gastroenterol　42　4　312-7　2007/04
  • 　Selective estrogen receptor modulator raloxifene-associated aggravation of nonalcoholic steatohepatitis.　Takamura T,Shimizu A,Komura T,Ando H,Zen Y,Minato H,Matsushita E,Kaneko S　Intern Med　46　9　579-81　2007
  • 　Impact of diabetes on recurrence of hepatocellular carcinoma after surgical treatment in patients with viral hepatitis.　Komura T,Mizukoshi E,Kita Y,Sakurai M,Takata Y,Arai K,Yamashita T,Ohta T,Shimizu K,Nakamoto Y,Honda M,Takamura T,Kaneko S　Am J Gastroenterol　102　9　1939-46　2007/09
  • 　Gene expression profiles in peripheral blood mononuclear cells reflect the pathophysiology of type 2 diabetes.　Takamura T,Honda M,Sakai Y,Ando H,Shimizu A,Ota T,Sakurai M,Misu H,Kurita S,Matsuzawa-Nagata N,Uchikata M,Nakamura S,Matoba R,Tanino M,Matsubara K,Kaneko S　Biochem Biophys Res Commun　361　2　379-84　2007/09
  • 　Possible role of alpha-cell insulin resistance in exaggerated glucagon responses to arginine in type 2 diabetes.　Tsuchiyama N,Takamura T,Ando H,Sakurai M,Shimizu A,Kato K,Kurita S,Kaneko S　DIABETES CARE　30　10　2583-7　2007/10
  • 　Lipid-induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet.　Matsuzawa N,Takamura T,Kurita S,Misu H,Ota T,Ando H,Yokoyama M,Honda M,Zen Y,Nakanuma Y,Miyamoto K,Kaneko S　HEPATOLOGY　46　5　1392-403　2007/11
  • 　New insulin sensitivity index from the oral glucose tolerance test.　Kazama Y,Takamura T,Sakurai M,Shindo H,Ohkubo E,Aida K,Harii N,Taki K,Kaneshige M,Tanaka S,Shimura H,Endo T,Kobayashi T　Diabetes Res Clin Pract　79　1　24-30　2008/01
  • 　Impact of diabetes mellitus on prognosis of patients infected with hepatitis C virus.　Kita Y,Mizukoshi E,Takamura T,Sakurai M,Takata Y,Arai K,Yamashita T,Nakamoto Y,Kaneko S　Metabolism　56　12　1682-8　2007/12
  • 　Regulation of adiponectin receptor expression in human liver and a hepatocyte cell line.　Shimizu A,Takamura T,Matsuzawa N,Nakamura S,Nabemoto S,Takeshita Y,Misu H,Kurita S,Sakurai M,Yokoyama M,Zen Y,Sasaki M,Nakanuma Y,Kaneko S　Metabolism　56　11　1478-85　2007/11
  • 　Cross talk of tumor necrosis factor-alpha and the renin-angiotensin system in tumor necrosis factor-alpha-induced plasminogen activator inhibitor-1 production from hepatocytes.　Takeshita Y,Takamura T,Ando H,Hamaguchi E,Takazakura A,Matsuzawa-Nagata N,Kaneko S　Eur J Pharmacol　579　1-3　426-32　2008/01
  • 　Effects of atorvastatin and pravastatin on glucose tolerance, adipokine levels and inflammatory markers in hypercholesterolaemic patients.　Ando H,Sugimoto K,Yanagihara H,Tsuruoka S,Saito T,Takamura T,Kaneko S,Fujimura A　Clin Exp Pharmacol Physiol　35　9　1012-7　2008/09
  • 　Olmesartan ameliorates a dietary rat model of non-alcoholic steatohepatitis through its pleiotropic effects.　Kurita S,Takamura T,Ota T,Matsuzawa-Nagata N,Kita Y,Uno M,Nabemoto S,Ishikura K,Misu H,Ando H,Zen Y,Nakanuma Y,Kaneko S　Eur J Pharmacol　588　2-3　316-24　2008/07
  • 　Tranilast, an antifibrogenic agent, ameliorates a dietary rat model of nonalcoholic steatohepatitis.　Uno M,Kurita S,Misu H,Ando H,Ota T,Matsuzawa-Nagata N,Kita Y,Nabemoto S,Akahori H,Zen Y,Nakanuma Y,Kaneko S,Takamura T　HEPATOLOGY　48　1　109-18　2008/07
  • 　Increased oxidative stress precedes the onset of high-fat diet-induced insulin resistance and obesity.　Matsuzawa-Nagata N,Takamura T,Ando H,Nakamura S,Kurita S,Misu H,Ota T,Yokoyama M,Honda M,Miyamoto K,Kaneko S　Metabolism　57　8　1071-7　2008/08
  • 　Transformation of p53-positive papillary thyroid carcinoma to anaplastic carcinoma of the liver following postoperative radioactive iodine-131 therapy.　Takeshita Y,Takamura T,Minato H,Misu H,Ando H,Yamashita T,Ikeda H,Nakanuma Y,Kaneko S　Intern Med　47　19　1709-12　2008
  • 　SAGE application in the study of diabetes.　Takamura T,Misu H,Yamashita T,Kaneko S　Curr Pharm Biotechnol　9　5　392-9　2008/10
  • 　Obesity upregulates genes involved in oxidative phosphorylation in livers of diabetic patients.　Takamura T,Misu H,Matsuzawa-Nagata N,Sakurai M,Ota T,Shimizu A,Kurita S,Takeshita Y,Ando H,Honda M,Kaneko S　Obesity (Silver Spring)　16　12　2601-9　2008/12
  • 　Clock gene expression in peripheral leucocytes of patients with type 2 diabetes.　Ando H,Takamura T,Matsuzawa-Nagata N,Shima KR,Eto T,Misu H,Shiramoto M,Tsuru T,Irie S,Fujimura A,Kaneko S　DIABETOLOGIA　52　2　329-35　2009/02
  • 　Clock gene expression in peripheral leucocytes of patients with type 2 diabetes.　Ando H,Takamura T,Matsuzawa-Nagata N,Shima KR,Eto T,Misu H,Shiramoto M,Tsuru T,Irie S,Fujimura A,Kaneko S　DIABETOLOGIA　52　2　329-35　2009/02
  • 　Altered hepatic gene expression profiles associated with myocardial ischemia.　Ootsuji H,Honda M,Kaneko S,Usui S,Okajima M,Okada H,Sakai Y,Takamura T,Horimoto K,Takamura M　Circ Cardiovasc Genet　3　1　68-77　2010/02
  • 　CD14+ monocytes are vulnerable and functionally impaired under endoplasmic reticulum stress in patients with type 2 diabetes.　Komura T,Sakai Y,Honda M,Takamura T,Matsushima K,Kaneko S　DIABETES　59　3　634-43　2010/03
  • 　Transient anti-GAD antibody positivity and acute pancreatitis with pancreas tail swelling in a patient with susceptible haplotype for type 1 diabetes mellitus.　Kahara T,Takamura T,Otoda T,Ishikura K,Matsushita E　Intern Med　48　21　1897-9　2009
  • 　Influence of age on clock gene expression in peripheral blood cells of healthy women.　Ando H,Ushijima K,Kumazaki M,Takamura T,Yokota N,Saito T,Irie S,Kaneko S,Fujimura A　J Gerontol A Biol Sci Med Sci　65　1　9-13　2010/01
  • 　J-shaped relationship between waist circumference and subsequent risk for Type 2 diabetes: an 8-year follow-up of relatively lean Japanese individuals.　Sakurai M,Miura K,Takamura T,Ishizaki M,Morikawa Y,Nakamura K,Yoshita K,Kido T,Naruse Y,Kaneko S,Nakagawa H　Diabet Med　26　8　753-9　2009/08
  • 　Clock gene expression in the liver and adipose tissues of non-obese type 2 diabetic Goto-Kakizaki rats.　Ando H,Ushijima K,Yanagihara H,Hayashi Y,Takamura T,Kaneko S,Fujimura A　Clin Exp Hypertens　31　3　201-7　2009/05
  • 　Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria.　Nakamura S,Takamura T,Matsuzawa-Nagata N,Takayama H,Misu H,Noda H,Nabemoto S,Kurita S,Ota T,Ando H,Miyamoto K,Kaneko S　J Biol Chem　284　22　14809-18　2009/05
  • 　Middle-aged Japanese women are resistant to obesity-related metabolic abnormalities.　Sakurai M,Takamura T,Miura K,Kaneko S,Nakagawa H　Metabolism　58　4　456-9　2009/04
  • 　The hepatic circadian clock is preserved in a lipid-induced mouse model of non-alcoholic steatohepatitis.　Ando H,Takamura T,Matsuzawa-Nagata N,Shima KR,Nakamura S,Kumazaki M,Kurita S,Misu H,Togawa N,Fukushima T,Fujimura A,Kaneko S　Biochem Biophys Res Commun　380　3　684-8　2009/03
  • 　Influence of age on clock gene expression in peripheral blood cells of healthy women.　Ando H,Ushijima K,Kumazaki M,Takamura T,Yokota N,Saito T,Irie S,Kaneko S,Fujimura A　J Gerontol A Biol Sci Med Sci　65　1　9-13　2010/01
  • 　Histological course of nonalcoholic fatty liver disease in Japanese patients: tight glycemic control, rather than weight reduction, ameliorates liver fibrosis.　Hamaguchi E,Takamura T,Sakurai M,Mizukoshi E,Zen Y,Takeshita Y,Kurita S,Arai K,Yamashita T,Sasaki M,Nakanuma Y,Kaneko S　DIABETES CARE　33　2　284-6　2010/02
  • 　A liver-derived secretory protein, selenoprotein P, causes insulin resistance.　Misu H,Takamura T,Takayama H,Hayashi H,Matsuzawa-Nagata N,Kurita S,Ishikura K,Ando H,Takeshita Y,Ota T,Sakurai M,Yamashita T,Mizukoshi E,Yamashita T,Honda M,Miyamoto K,Kubota T,Kubota N,Kadowaki T,Kim HJ,Lee IK,Minokoshi Y,Saito Y,Takahashi K,Yamada Y,Takakura N,Kaneko S　Cell Metab　12　5　483-95　2010/11
  • 　Effect of pioglitazone on muscle sympathetic nerve activity in type 2 diabetes mellitus with α-glucosidase inhibitor.　Kobayashi D,Takamura M,Murai H,Usui S,Ikeda T,Inomata J,Takashima S,Kato T,Furusho H,Takeshita Y,Ota T,Takamura T,Kaneko S　Auton Neurosci　158　1-2　86-91　2010/12
  • 　Associations of metabolic parameters and ethanol consumption with messenger RNA expression of clock genes in healthy men.　Ando H,Ushijima K,Kumazaki M,Eto T,Takamura T,Irie S,Kaneko S,Fujimura A　Chronobiol Int　27　1　194-203　2010/01
  • 　Altered hepatic gene expression profiles associated with myocardial ischemia.　Ootsuji H,Honda M,Kaneko S,Usui S,Okajima M,Okada H,Sakai Y,Takamura T,Horimoto K,Takamura M　Circ Cardiovasc Genet　3　1　68-77　2010/02
  • 　CD14+ monocytes are vulnerable and functionally impaired under endoplasmic reticulum stress in patients with type 2 diabetes.　Komura T,Sakai Y,Honda M,Takamura T,Matsushima K,Kaneko S　DIABETES　59　3　634-43　2010/03
  • 　Concentration-dependent dual effects of hydrogen peroxide on insulin signal transduction in H4IIEC hepatocytes.　Iwakami S,Misu H,Takeda T,Sugimori M,Matsugo S,Kaneko S,Takamura T　PLoS One　6　11　e27401　2011
  • 　Characteristics of patients with nonalcoholic steatohepatitis who develop hepatocellular carcinoma.　Yasui K,Hashimoto E,Komorizono Y,Koike K,Arii S,Imai Y,Shima T,Kanbara Y,Saibara T,Mori T,Kawata S,Uto H,Takami S,Sumida Y,Takamura T,Kawanaka M,Okanoue T,Japan NASH Study Group, Ministry of Health, Labour, and Welfare of Japan　Clin Gastroenterol Hepatol　9　5　428-33; quiz e50　2011/05
  • 　[The cutting-edge of medicine; clinical and molecular pathology of type 2 diabetic liver].　Takamura T,Misu H,Kaneko S　Nihon Naika Gakkai Zasshi　100　6　1670-6　2011/06
  • 　Dietary glycemic index and risk of type 2 diabetes mellitus in middle-aged Japanese men.　Sakurai M,Nakamura K,Miura K,Takamura T,Yoshita K,Morikawa Y,Ishizaki M,Kido T,Naruse Y,Suwazono Y,Kaneko S,Sasaki S,Nakagawa H　Metabolism　61　1　47-55　2012/01
  • 　Identification of blood biomarkers of aging by transcript profiling of whole blood.　Nakamura S,Kawai K,Takeshita Y,Honda M,Takamura T,Kaneko S,Matoba R,Matsubara K　Biochem Biophys Res Commun　418　2　313-8　2012/02
  • 　Slowly progressive insulin-dependent diabetes in a patient with primary biliary cirrhosis with portal hypertension-type progression.　Takeshita Y,Takamura T,Inoue O,Okumura M,Kato K,Sunagozaka H,Arai K,Misu H,Nakamura M,Nakanuma Y,Kaneko S　Intern Med　51　1　79-82　2012
  • 　CCR5 plays a critical role in obesity-induced adipose tissue inflammation and insulin resistance by regulating both macrophage recruitment and M1/M2 status.　Kitade H,Sawamoto K,Nagashimada M,Inoue H,Yamamoto Y,Sai Y,Takamura T,Yamamoto H,Miyamoto K,Ginsberg HN,Mukaida N,Kaneko S,Ota T　DIABETES　61　7　1680-90　2012/07
  • 　[Novel strategies that target hepatokines for treatment of type 2 diabetes].　Misu H,Takamura T,Kaneko S　Nihon Rinsho　70　1　157-63　2012/01
  • 　Inverse correlation between serum levels of selenoprotein P and adiponectin in patients with type 2 diabetes.　Misu H,Ishikura K,Kurita S,Takeshita Y,Ota T,Saito Y,Takahashi K,Kaneko S,Takamura T　PLoS One　7　4　e34952　2012
  • 　Beneficial effect of branched-chain amino acid supplementation on glycemic control in chronic hepatitis C patients with insulin resistance: implications for type 2 diabetes.　Takeshita Y,Takamura T,Kita Y,Ando H,Ueda T,Kato K,Misu H,Sunagozaka H,Sakai Y,Yamashita T,Mizukoshi E,Honda M,Kaneko S　Metabolism　61　10　1388-94　2012/10
  • 　Self-reported speed of eating and 7-year risk of type 2 diabetes mellitus in middle-aged Japanese men.　Sakurai M,Nakamura K,Miura K,Takamura T,Yoshita K,Nagasawa SY,Morikawa Y,Ishizaki M,Kido T,Naruse Y,Suwazono Y,Sasaki S,Nakagawa H　Metabolism　61　11　1566-71　2012/11
  • 　Pharmacokinetics and pharmacodynamics of insulin aspart in patients with type 2 diabetes: assessment using a meal tolerance test under clinical conditions.　Ando H,Kurita S,Shimizu A,Kato K,Ishikura K,Taji K,Uno M,Takeshita Y,Misu H,Fujimura A,Kaneko S,Takamura T　Clin Exp Pharmacol Physiol　39　6　528-34　2012/06
  • 　Duodenal adenocarcinoma with neuroendocrine features in a patient with acromegaly and thyroid papillary adenocarcinoma: a unique combination of endocrine neoplasia.　Kato K,Takeshita Y,Misu H,Ishikura K,Kakinoki K,Sawada-Kitamura S,Kaneko S,Takamura T　Endocr J　59　9　791-6　2012
  • 　Genetic polymorphisms of the human PNPLA3 gene are strongly associated with severity of non-alcoholic fatty liver disease in Japanese.　Kawaguchi T,Sumida Y,Umemura A,Matsuo K,Takahashi M,Takamura T,Yasui K,Saibara T,Hashimoto E,Kawanaka M,Watanabe S,Kawata S,Imai Y,Kokubo M,Shima T,Park H,Tanaka H,Tajima K,Yamada R,Matsuda F,Takeshi Okanoue,Japan Study Group of Nonalcoholic Fatty Liver Disease　PLoS One　7　6　e38322　2012
  • 　Fatty liver as a consequence and cause of insulin resistance: lessons from type 2 diabetic liver.　Takamura T,Misu H,Ota T,Kaneko S　Endocr J　59　9　745-63　2012
  • 　Metformin prevents and reverses inflammation in a non-diabetic mouse model of nonalcoholic steatohepatitis.　Kita Y,Takamura T,Misu H,Ota T,Kurita S,Takeshita Y,Uno M,Matsuzawa-Nagata N,Kato K,Ando H,Fujimura A,Hayashi K,Kimura T,Ni Y,Otoda T,Miyamoto K,Zen Y,Nakanuma Y,Kaneko S　PLoS One　7　9　e43056　2012
  • 　Clinicopathological features of liver injury in patients with type 2 diabetes mellitus and comparative study of histologically proven nonalcoholic fatty liver diseases with or without type 2 diabetes mellitus.　Shima T,Uto H,Ueki K,Takamura T,Kohgo Y,Kawata S,Yasui K,Park H,Nakamura N,Nakatou T,Tanaka N,Umemura A,Mizuno M,Tanaka J,Okanoue T　J Gastroenterol　48　4　515-25　2013/04
  • 　ER stress induced impaired TLR signaling and macrophage differentiation of human monocytes.　Komura T,Sakai Y,Honda M,Takamura T,Wada T,Kaneko S　Cell Immunol　282　1　44-52　2013/03
  • 　Proteasome dysfunction mediates obesity-induced endoplasmic reticulum stress and insulin resistance in the liver.　Otoda T,Takamura T,Misu H,Ota T,Murata S,Hayashi H,Takayama H,Kikuchi A,Kanamori T,Shima KR,Lan F,Takeda T,Kurita S,Ishikura K,Kita Y,Iwayama K,Kato K,Uno M,Takeshita Y,Yamamoto M,Tokuyama K,Iseki S,Tanaka K,Kaneko S　DIABETES　62　3　811-24　2013/03
  • 　Dosing time-dependent effect of raloxifene on plasma plasminogen activator inhibitor-1 concentrations in post-menopausal women with osteoporosis.　Ando H,Otoda T,Ookami H,Nagai Y,Inano A,Takamura T,Ushijima K,Hosohata K,Matsushita E,Saito T,Kaneko S,Fujimura A　Clin Exp Pharmacol Physiol　40　3　227-32　2013/03
  • 　Quantitative analysis of hepatic fat fraction by single-breath-holding MR spectroscopy with T₂ correction: phantom and clinical study with histologic assessment.　Hayashi N,Miyati T,Minami T,Takeshita Y,Ryu Y,Matsuda T,Ohno N,Hamaguchi T,Kato K,Takamura T,Matsui O　Radiol Phys Technol　6　1　219-25　2013/01
  • 　Sugar-sweetened beverage and diet soda consumption and the 7-year risk for type 2 diabetes mellitus in middle-aged Japanese men.　Sakurai M,Nakamura K,Miura K,Takamura T,Yoshita K,Nagasawa SY,Morikawa Y,Ishizaki M,Kido T,Naruse Y,Suwazono Y,Sasaki S,Nakagawa H　Eur J Nutr　2014/06
  • 　Regulation of the physiological effects of peroxidovanadium(V) complexes by the electronic nature of ligands.　Sugiyama H,Matsugo S,Misu H,Takamura T,Kaneko S,Kanatani Y,Kaido M,Mihara C,Abeywardana N,Sakai A,Sato K,Miyashita Y,Kanamori K　J Inorg Biochem　121　66-76　2013/04
  • 　Adipose tissue-derived stem cells as a regenerative therapy for a mouse steatohepatitis-induced cirrhosis model.　Seki A,Sakai Y,Komura T,Nasti A,Yoshida K,Higashimoto M,Honda M,Usui S,Takamura M,Takamura T,Ochiya T,Furuichi K,Wada T,Kaneko S　HEPATOLOGY　58　3　1133-42　2013/09
  • 　[Diabetes mellitus related common medical disorders: recent progress in diagnosis and treatment. Topics: I. Pathophysiology, diagnosis and treatment; 1. Nonalcoholic fatty liver disease].　Nihon Naika Gakkai Zasshi　102　4　836-44　2013/04
  • 　Long-term Outcomes of Japanese Type 2 Diabetic Patients With Biopsy-Proven Diabetic Nephropathy.　Shimizu M,Furuichi K,Toyama T,Kitajima S,Hara A,Kitagawa K,Iwata Y,Sakai N,Takamura T,Yoshimura M,Yokoyama H,Kaneko S,Wada T,and the Kanazawa Study Group for Renal Diseases and Hypertension　DIABETES CARE　2013/11
  • 　Cyclosporine A inhibits the secretion of certain anterior pituitary hormones in patients with nephrotic syndrome.　Nagai Y,Miyakoshi H,Ohsawa K,Ieki Y,Takamura T,Kobayashi K　Endocrinol Jpn　39　1　129-32　1992/02
  • 　Regulatory role of CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase) in insulin secretion by glucose in pancreatic beta cells. Enhanced insulin secretion in CD38-expressing transgenic mice.　Kato I,Takasawa S,Akabane A,Tanaka O,Abe H,Takamura T,Suzuki Y,Nata K,Yonekura H,Yoshimoto T　J Biol Chem　270　50　30045-50　1995/12
  • 　The structure of the Aplysia kurodai gene encoding ADP-ribosyl cyclase, a second-messenger enzyme.　Nata K,Sugimoto T,Tohgo A,Takamura T,Noguchi N,Matsuoka A,Numakunai T,Shikama K,Yonekura H,Takasawa S　GENE　158　2　213-8　1995/06
  • 　Assignment of CD38, the gene encoding human leukocyte antigen CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase), to chromosome 4p15.　Nakagawara K,Mori M,Takasawa S,Nata K,Takamura T,Berlova A,Tohgo A,Karasawa T,Yonekura H,Takeuchi T　Cytogenet Cell Genet　69　1-2　38-9　1995
  • 　An adult case of neurohypophyseal ectopy presenting ACTH deficiency and partial GH deficiency.　Takamura T,Ohsawa K,Nishimura Y,Yamagishi S,Komatsu Y,Iwata A,Osada S,Nagai Y,Miyakoshi H,Kobayashi K　Endocr J　42　1　83-8　1995/02
  • 　Inhibitory effect of cyclosporin A on prolactin synthesis in GH3 cells.　Nagai Y,Ohsawa K,Ohta M,Hisada A,Yamashita H,Yoshizawa M,Yamamoto Y,Takamura T,Kobayashi K　Tohoku J Exp Med　180　4　337-46　1996/12
  • 　Human gene encoding CD38 (ADP-ribosyl cyclase/cyclic ADP-ribose hydrolase): organization, nucleotide sequence and alternative splicing.　Nata K,Takamura T,Karasawa T,Kumagai T,Hashioka W,Tohgo A,Yonekura H,Takasawa S,Nakamura S,Okamoto H　GENE　186　2　285-92　1997/02
  • 　Elevated serum levels of soluble vascular cell adhesion molecule-1 in NIDDM patients with proliferative diabetic retinopathy.　Yoshizawa M,Nagai Y,Ohsawa K,Ohta M,Yamashita H,Hisada A,Miyamoto I,Miura K,Takamura T,Kobayashi K　Diabetes Res Clin Pract　42　1　65-70　1998/10
  • 　Amyloid goiter presented as a subacute thyroiditis-like symptom in a patient with hypersensitivity vasculitis.　Nagai Y,Ohta M,Yokoyama H,Takamura T,Kobayashi KI　Endocr J　45　3　421-5　1998/06
  • 　Antibodies to GAD in diabetic patients with chronic hepatitis C.　Ando H,Nagai Y,Yokoyama M,Takamura T,Kobayashi K　Diabet Med　15　9　797　1998/09
  • 　Transgenic mice overexpressing type 2 nitric-oxide synthase in pancreatic beta cells develop insulin-dependent diabetes without insulitis.　Takamura T,Kato I,Kimura N,Nakazawa T,Yonekura H,Takasawa S,Okamoto H　J Biol Chem　273　5　2493-6　1998/01
  • 　Adrenal insufficiency due to metastatic hepatocellular carcinoma.　Takamura T,Nagai Y,Yamashita H,Nohara E,Ando H,Kagaya M,Urabe T,Kaneko S,Kobayashi K　Endocr J　46　4　591-6　1999/08
  • 　A patient with GH-producing pituitary adenoma presenting with a binasal superior quadrantanopsia.　Nagai Y,Takamura T,Ando H,Nohara E,Yamashita H,Ieki Y,Takazakura E,Kobayashi K　Endocr J　46　2　345-6　1999/04
  • 　Serum soluble adhesion molecule concentrations are not regulated by acute hyperinsulinaemia in healthy men.　Nagai Y,Takamura T,Nohara E,Yamashita H,Kobayashi K　Diabet Med　16　7　618　1999/07
  • 　Pioglitazone prevents mice from multiple low-dose streptozotocin-induced insulitis and diabetes.　Takamura T,Ando H,Nagai Y,Yamashita H,Nohara E,Kobayashi K　Diabetes Res Clin Pract　44　2　107-14　1999/05
  • 　Acute hyperinsulinemia reduces plasma concentrations of homocysteine in healthy men.　Nagai Y,Takamura T,Nohara E,Yamashita H,Kobayashi K　DIABETES CARE　22　6　1004　1999/06
  • 　Variation of the fatty acid binding protein 2 gene is not associated with obesity and insulin resistance in Japanese subjects.　Hayakawa T,Nagai Y,Nohara E,Yamashita H,Takamura T,Abe T,Nomura G,Kobayashi K　Metabolism　48　5　655-7　1999/05
  • 　Phenotypic characterization of the beta3-adrenergic receptor mutation and the uncoupling protein 1 polymorphism in Japanese men.　Hayakawa T,Nagai Y,Taniguchi M,Yamashita H,Takamura T,Abe T,Nomura G,Kobayashi K　Metabolism　48　5　636-40　1999/05
  • 　Does acute hyperinsulinaemia change plasma adrenomedullin concentration in healthy men?　Nagai Y,Yamashita H,Takamura T,Kobayashi KI　Diabet Med　17　3　249-50　2000/03
  • 　Inhibitory effect of troglitazone on tumor necrosis factor alpha-induced expression of monocyte chemoattractant protein-1 in human mesangial cells.　Ohta MY,Nagai Y,Takamura T,Nohara E,Kobayashi K　Metabolism　49　2　163-6　2000/02
  • 　Gln27Glu and Arg16Gly polymorphisms of the beta2-adrenergic receptor gene are not associated with obesity in Japanese men.　Hayakawa T,Nagai Y,Kahara T,Yamashita H,Takamura T,Abe T,Nomura G,Kobayashi K　Metabolism　49　9　1215-8　2000/09
  • 　Plasma levels of vascular endothelial growth factor in patients with acromegaly.　Nagai Y,Ando H,Nohara E,Yamashita H,Takamura T,Kobayashi K　Horm Metab Res　32　8　326-9　2000/08
  • 　Cerivastatin improves survival of mice with lipopolysaccharide-induced sepsis.　Ando H,Takamura T,Ota T,Nagai Y,Kobayashi K　J Pharmacol Exp Ther　294　3　1043-6　2000/09
  • 　Ketosis-onset diabetes without islet-associated autoantibodies in a patient with MELAS.　Takamura T,Nagai Y,Torita M,Yamashita H,Kahara T,Koshino Y,Kobayashi K　DIABETES CARE　23　7　1018-9　2000/07
  • 　Inhibitory effect of troglitazone on TNF-alpha-induced expression of monocyte chemoattractant protein-1 (MCP-1) in human endothelial cells.　Ohta MY,Nagai Y,Takamura T,Nohara E,Kobayashi K　Diabetes Res Clin Pract　48　3　171-6　2000/06
  • 　Ischemic colitis probably induced by refractory constipation after voglibose administration in a patient with total gastrectomy.　Nagai Y,Yamashita H,Nohara E,Takamura T,Kobayashi K　Intern Med　39　10　861　2000/10
  • 　Tumor necrosis factor-beta gene NcoI polymorphism decreases insulin resistance in Japanese men.　Hayakawa T,Nagai Y,Taniguchi M,Yamashita H,Takamura T,Abe T,Nomura G,Kobayashi K　Metabolism　49　11　1506-9　2000/11
  • 　Extramedullary plasmacytoma in the adrenal incidentaloma.　Kahara T,Nagai Y,Yamashita H,Nohara E,Kobayashi K,Takamura T　Clin Endocrinol (Oxf)　55　2　267-70　2001/08
  • 　Severe hypercholesterolemia in a double heterozygote for lipoprotein lipase deficiency (LPL(Arita)) and apolipoprotein epsilon4: a report of a family with LPL(Arita).　Ando H,Nishimura Y,Nemoto T,Takamura T,Nagai Y,Kobayashi K　Endocr J　48　1　113-8　2001/02
  • 　Stage-specific effects of a thiazolidinedione on proliferation, differentiation and PPARgamma mRNA expression in 3T3-L1 adipocytes.　Takamura T,Nohara E,Nagai Y,Kobayashi K　Eur J Pharmacol　422　1-3　23-9　2001/06
  • 　A case of refractory hypothyroidism requiring daily intravenous thyroxine.　Nagaoka T,Miyakoshi H,Takamura T,Nagai Y,Matsushita S,Kaneko S,Kobayashi K　J Int Med Res　30　4　463-5　2002/07
  • 　Thiazolidinedione derivatives ameliorate albuminuria in streptozotocin-induced diabetic spontaneous hypertensive rat.　Yamashita H,Nagai Y,Takamura T,Nohara E,Kobayashi K　Metabolism　51　4　403-8　2002/04
  • 　IL-6 gene polymorphism -174G/C does not contribute substantially to hyperlipidaemia and Type II diabetes mellitus in Japanese men.　Hayakawa T,Takamura T,Hisada A,Abe T,Nomura G,Kobayashi K　DIABETOLOGIA　45　3　453-4　2002/03
  • 　Prediction of exercise-mediated changes in metabolic markers by gene polymorphism.　Kahara T,Takamura T,Hayakawa T,Nagai Y,Yamaguchi H,Katsuki T,Katsuki K,Katsuki M,Kobayashi K　Diabetes Res Clin Pract　57　2　105-10　2002/08
  • 　Preobesity in World Health Organization classification involves the metabolic syndrome in Japanese.　Ota T,Takamura T,Hirai N,Kobayashi K　DIABETES CARE　25　7　1252-3　2002/07
  • 　Tumor necrosis factor-alpha and troglitazone regulate plasminogen activator inhibitor type 1 production through extracellular signal-regulated kinase- and nuclear factor-kappaB-dependent pathways in cultured human umbilical vein endothelial cells.　Hamaguchi E,Takamura T,Shimizu A,Nagai Y　J Pharmacol Exp Ther　307　3　987-94　2003/12
  • 　Predictive value of autoantibodies to IA-2 for insulin requirements in Japanese subjects with type 1 diabetes.　Ota T,Takamura T,Bando Y,Usuda R,Nagai Y　DIABETES CARE　26　11　3188-9　2003/11
  • 　Does pravastatin affect circulating levels of soluble TNF receptor 2 in hypercholesterolemic patients?　Ando H,Takamura T,Kobayashi K,Misu H,Osawa K　ATHEROSCLEROSIS　166　2　413-4　2003/02
  • 　PPARgamma gene polymorphism is associated with exercise-mediated changes of insulin resistance in healthy men.　Kahara T,Takamura T,Hayakawa T,Nagai Y,Yamaguchi H,Katsuki T,Katsuki K,Katsuki M,Kobayashi K　Metabolism　52　2　209-12　2003/02
  • 　Preventive effect of cerivastatin on diabetic nephropathy through suppression of glomerular macrophage recruitment in a rat model.　Ota T,Takamura T,Ando H,Nohara E,Yamashita H,Kobayashi K　DIABETOLOGIA　46　6　843-51　2003/06
  • 　Fulminating onset type 1 diabetes with positivity for anti-GAD antibody and elevated pancreatic exocrine enzyme concentrations.　Kahara T,Takamura T,Ando H,Sakurai M,Ota T,Misaki T,Oba S,Iguchi M,Komori K,Kobayashi K　Intern Med　42　6　517-20　2003/06
  • 　The transient appearance of anti-GAD antibody in a type 2 diabetic patient with empyema.　Kahara T,Takamura T,Ando H,Misaki T,Komori K,Ohya N,Kobayashi K　Intern Med　42　6　541-2　2003/06
  • 　Modulating effects of olanzapine on the development of diabetic ketoacidosis.　Tsuchiyama N,Ando H,Ota T,Sakurai M,Takamura T　Diabet Med　21　3　300-1　2004/03
  • 　The specific p38 mitogen-activated protein kinase pathway inhibitor FR167653 keeps insulitis benign in nonobese diabetic mice.　Ando H,Kurita S,Takamura T　Life Sci　74　14　1817-27　2004/02
  • 　Genes for systemic vascular complications are differentially expressed in the livers of type 2 diabetic patients.　Takamura T,Sakurai M,Ota T,Ando H,Honda M,Kaneko S　DIABETOLOGIA　47　4　638-47　2004/04
  • 　Effects of pravastatin on the expression of ATP-binding cassette transporter A1.　Ando H,Tsuruoka S,Yamamoto H,Takamura T,Kaneko S,Fujimura A　J Pharmacol Exp Ther　311　1　420-5　2004/10
  • 　Gln27Glu polymorphism of the beta2 adrenergic receptor gene in healthy Japanese men is associated with the change of fructosamine level caused by exercise.　Kahara T,Hayakawa T,Nagai Y,Shimizu A,Takamura T　Diabetes Res Clin Pract　64　3　207-12　2004/06
  • 　Prostaglandin E1 in lipid microspheres ameliorates diabetic peripheral neuropathy: clinical usefulness of Semmes-Weinstein monofilaments for evaluating diabetic sensory abnormality.　Akahori H,Takamura T,Hayakawa T,Ando H,Yamashita H,Kobayashi K　Diabetes Res Clin Pract　64　3　153-9　2004/06
  • 　Relationship between plasma hANP level and pretibial edema by pioglitazone treatment.　Kahara T,Takamura T,Misaki T,Sakurai M,Takeshita Y,Shimizu A,Kaneko S　Endocr J　52　3　373-6　2005/06
  • 　Tranilast prevents the progression of experimental diabetic nephropathy through suppression of enhanced extracellular matrix gene expression.　Akahori H,Ota T,Torita M,Ando H,Kaneko S,Takamura T　J Pharmacol Exp Ther　314　2　514-21　2005/08
  • 　Regulation of cholesterol 7alpha-hydroxylase mRNA expression in C57BL/6 mice fed an atherogenic diet.　Ando H,Tsuruoka S,Yamamoto H,Takamura T,Kaneko S,Fujimura A　ATHEROSCLEROSIS　178　2　265-9　2005/02
  • 　Significance of IA-2 antibody in Japanese type 1 diabetes: its association with GAD antibody.　Ota T,Takamura T,Nagai Y,Bando Y,Usuda R　Diabetes Res Clin Pract　67　1　63-9　2005/01
  • 　Measurement of thyroid blood flow area is useful for diagnosing the cause of thyrotoxicosis.　Kurita S,Sakurai M,Kita Y,Ota T,Ando H,Kaneko S,Takamura T　THYROID　15　11　1249-52　2005/11
  • 　Subacute thyroiditis developed in identical twins two years apart.　Hamaguchi E,Nishimura Y,Kaneko S,Takamura T　Endocr J　52　5　559-62　2005/10
  • 　Effects of grapefruit juice on the pharmacokinetics of pitavastatin and atorvastatin.　Ando H,Tsuruoka S,Yanagihara H,Sugimoto K,Miyata M,Yamazoe Y,Takamura T,Kaneko S,Fujimura A　Br J Clin Pharmacol　60　5　494-7　2005/11
  • 　Pancreatic exocrine and endocrine events occur concomitantly but independently during the course of fulminant type 1 diabetes.　Kahara T,Takamura T,Sakurai M,Misu H,Usuda R,Hayakawa T,Nishimura Y,Bando Y,Nagaoka T,Nagai Y,Kaneko S　Diabetes Res Clin Pract　71　3　241-6　2006/03
  • 　Daily rhythms of P-glycoprotein expression in mice.　Ando H,Yanagihara H,Sugimoto K,Hayashi Y,Tsuruoka S,Takamura T,Kaneko S,Fujimura A　Chronobiol Int　22　4　655-65　2005
  • 　cDNA microarray analysis of autoimmune hepatitis, primary biliary cirrhosis and consecutive disease manifestation.　Honda M,Kawai H,Shirota Y,Yamashita T,Takamura T,Kaneko S　J Autoimmun　25　2　133-40　2005/09
  • 　Rhythmic messenger ribonucleic acid expression of clock genes and adipocytokines in mouse visceral adipose tissue.　Ando H,Yanagihara H,Hayashi Y,Obi Y,Tsuruoka S,Takamura T,Kaneko S,Fujimura A　ENDOCRINOLOGY　146　12　5631-6　2005/12
  • 　Gender differences in the association between anthropometric indices of obesity and blood pressure in Japanese.　Sakurai M,Miura K,Takamura T,Ota T,Ishizaki M,Morikawa Y,Kido T,Naruse Y,Nakagawa H　Hypertens Res　29　2　75-80　2006/02
  • 　Pancreatic exocrine and endocrine events occur concomitantly but independently during the course of fulminant type 1 diabetes.　Kahara T,Takamura T,Sakurai M,Misu H,Usuda R,Hayakawa T,Nishimura Y,Bando Y,Nagaoka T,Nagai Y,Kaneko S　Diabetes Res Clin Pract　71　3　241-6　2006/03
  • 　Factors associated with improvement of fasting plasma glucose level by mealtime dosing of a rapid-acting insulin analog in type 2 diabetes.　Takamura T,Sakurai M,Nakamura M,Shimizu A,Ota T,Misu H,Takeshita Y,Tsuchiyama N,Kurita S,Ando H,Kaneko S　Diabetes Res Clin Pract　75　3　278-84　2007/03
  • 　Erythrocyte sorbitol level as a predictor of the efficacy of epalrestat treatment for diabetic peripheral polyneuropathy.　Ando H,Takamura T,Nagai Y,Kaneko S,Kanazawa University Multicenter Diabetes Study Group　J Diabetes Complications　20　6　367-70　2006/11
  • 　Insulin resistance accelerates a dietary rat model of nonalcoholic steatohepatitis.　Ota T,Takamura T,Kurita S,Matsuzawa N,Kita Y,Uno M,Akahori H,Misu H,Sakurai M,Zen Y,Nakanuma Y,Kaneko S　GASTROENTEROLOGY　132　1　282-93　2007/01
  • 　Genes involved in oxidative phosphorylation are coordinately upregulated with fasting hyperglycaemia in livers of patients with type 2 diabetes.　Misu H,Takamura T,Matsuzawa N,Shimizu A,Ota T,Sakurai M,Ando H,Arai K,Yamashita T,Honda M,Yamashita T,Kaneko S　DIABETOLOGIA　50　2　268-77　2007/02
  • 　Tumor necrosis factor-alpha-induced production of plasminogen activator inhibitor 1 and its regulation by pioglitazone and cerivastatin in a nonmalignant human hepatocyte cell line.　Takeshita Y,Takamura T,Hamaguchi E,Shimizu A,Ota T,Sakurai M,Kaneko S　Metabolism　55　11　1464-72　2006/11
  • 　Profile of rhythmic gene expression in the livers of obese diabetic KK-A(y) mice.　Ando H,Oshima Y,Yanagihara H,Hayashi Y,Takamura T,Kaneko S,Fujimura A　Biochem Biophys Res Commun　346　4　1297-302　2006/08
  • 　Possible role of alpha-cell insulin resistance in exaggerated glucagon responses to arginine in type 2 diabetes.　Tsuchiyama N,Takamura T,Ando H,Sakurai M,Shimizu A,Kato K,Kurita S,Kaneko S　DIABETES CARE　30　10　2583-7　2007/10
  • 　Impact of diabetes on recurrence of hepatocellular carcinoma after surgical treatment in patients with viral hepatitis.　Komura T,Mizukoshi E,Kita Y,Sakurai M,Takata Y,Arai K,Yamashita T,Ohta T,Shimizu K,Nakamoto Y,Honda M,Takamura T,Kaneko S　Am J Gastroenterol　102　9　1939-46　2007/09
  • 　Pioglitazone in nonalcoholic steatohepatitis.　Ota T,Takamura T,Kaneko S　N Engl J Med　356　10　1068; author reply 1068-9　2007/03
  • 　Selective estrogen receptor modulator raloxifene-associated aggravation of nonalcoholic steatohepatitis.　Takamura T,Shimizu A,Komura T,Ando H,Zen Y,Minato H,Matsushita E,Kaneko S　Intern Med　46　9　579-81　2007
  • 　Liver steatosis, but not fibrosis, is associated with insulin resistance in nonalcoholic fatty liver disease.　Sakurai M,Takamura T,Ota T,Ando H,Akahori H,Kaji K,Sasaki M,Nakanuma Y,Miura K,Kaneko S　J Gastroenterol　42　4　312-7　2007/04
  • 　New insulin sensitivity index from the oral glucose tolerance test.　Kazama Y,Takamura T,Sakurai M,Shindo H,Ohkubo E,Aida K,Harii N,Taki K,Kaneshige M,Tanaka S,Shimura H,Endo T,Kobayashi T　Diabetes Res Clin Pract　79　1　24-30　2008/01
  • 　Gene expression profiles in peripheral blood mononuclear cells reflect the pathophysiology of type 2 diabetes.　Takamura T,Honda M,Sakai Y,Ando H,Shimizu A,Ota T,Sakurai M,Misu H,Kurita S,Matsuzawa-Nagata N,Uchikata M,Nakamura S,Matoba R,Tanino M,Matsubara K,Kaneko S　Biochem Biophys Res Commun　361　2　379-84　2007/09
  • 　Regulation of adiponectin receptor expression in human liver and a hepatocyte cell line.　Shimizu A,Takamura T,Matsuzawa N,Nakamura S,Nabemoto S,Takeshita Y,Misu H,Kurita S,Sakurai M,Yokoyama M,Zen Y,Sasaki M,Nakanuma Y,Kaneko S　Metabolism　56　11　1478-85　2007/11
  • 　Lipid-induced oxidative stress causes steatohepatitis in mice fed an atherogenic diet.　Matsuzawa N,Takamura T,Kurita S,Misu H,Ota T,Ando H,Yokoyama M,Honda M,Zen Y,Nakanuma Y,Miyamoto K,Kaneko S　HEPATOLOGY　46　5　1392-403　2007/11
  • 　Cross talk of tumor necrosis factor-alpha and the renin-angiotensin system in tumor necrosis factor-alpha-induced plasminogen activator inhibitor-1 production from hepatocytes.　Takeshita Y,Takamura T,Ando H,Hamaguchi E,Takazakura A,Matsuzawa-Nagata N,Kaneko S　Eur J Pharmacol　579　1-3　426-32　2008/01
  • 　Impact of diabetes mellitus on prognosis of patients infected with hepatitis C virus.　Kita Y,Mizukoshi E,Takamura T,Sakurai M,Takata Y,Arai K,Yamashita T,Nakamoto Y,Kaneko S　Metabolism　56　12　1682-8　2007/12
  • 　Increased oxidative stress precedes the onset of high-fat diet-induced insulin resistance and obesity.　Matsuzawa-Nagata N,Takamura T,Ando H,Nakamura S,Kurita S,Misu H,Ota T,Yokoyama M,Honda M,Miyamoto K,Kaneko S　Metabolism　57　8　1071-7　2008/08
  • 　Tranilast, an antifibrogenic agent, ameliorates a dietary rat model of nonalcoholic steatohepatitis.　Uno M,Kurita S,Misu H,Ando H,Ota T,Matsuzawa-Nagata N,Kita Y,Nabemoto S,Akahori H,Zen Y,Nakanuma Y,Kaneko S,Takamura T　HEPATOLOGY　48　1　109-18　2008/07
  • 　Transformation of p53-positive papillary thyroid carcinoma to anaplastic carcinoma of the liver following postoperative radioactive iodine-131 therapy.　Takeshita Y,Takamura T,Minato H,Misu H,Ando H,Yamashita T,Ikeda H,Nakanuma Y,Kaneko S　Intern Med　47　19　1709-12　2008
  • 　Olmesartan ameliorates a dietary rat model of non-alcoholic steatohepatitis through its pleiotropic effects.　Kurita S,Takamura T,Ota T,Matsuzawa-Nagata N,Kita Y,Uno M,Nabemoto S,Ishikura K,Misu H,Ando H,Zen Y,Nakanuma Y,Kaneko S　Eur J Pharmacol　588　2-3　316-24　2008/07
  • 　Clock gene expression in peripheral leucocytes of patients with type 2 diabetes.　Ando H,Takamura T,Matsuzawa-Nagata N,Shima KR,Eto T,Misu H,Shiramoto M,Tsuru T,Irie S,Fujimura A,Kaneko S　DIABETOLOGIA　52　2　329-35　2009/02
  • 　SAGE application in the study of diabetes.　Takamura T,Misu H,Yamashita T,Kaneko S　Curr Pharm Biotechnol　9　5　392-9　2008/10
  • 　Obesity upregulates genes involved in oxidative phosphorylation in livers of diabetic patients.　Takamura T,Misu H,Matsuzawa-Nagata N,Sakurai M,Ota T,Shimizu A,Kurita S,Takeshita Y,Ando H,Honda M,Kaneko S　Obesity (Silver Spring)　16　12　2601-9　2008/12
  • 　Effects of atorvastatin and pravastatin on glucose tolerance, adipokine levels and inflammatory markers in hypercholesterolaemic patients.　Ando H,Sugimoto K,Yanagihara H,Tsuruoka S,Saito T,Takamura T,Kaneko S,Fujimura A　Clin Exp Pharmacol Physiol　35　9　1012-7　2008/09
  • 　Clock gene expression in peripheral leucocytes of patients with type 2 diabetes.　Ando H,Takamura T,Matsuzawa-Nagata N,Shima KR,Eto T,Misu H,Shiramoto M,Tsuru T,Irie S,Fujimura A,Kaneko S　DIABETOLOGIA　52　2　329-35　2009/02
  • 　J-shaped relationship between waist circumference and subsequent risk for Type 2 diabetes: an 8-year follow-up of relatively lean Japanese individuals.　Sakurai M,Miura K,Takamura T,Ishizaki M,Morikawa Y,Nakamura K,Yoshita K,Kido T,Naruse Y,Kaneko S,Nakagawa H　Diabet Med　26　8　753-9　2009/08
  • 　Clock gene expression in the liver and adipose tissues of non-obese type 2 diabetic Goto-Kakizaki rats.　Ando H,Ushijima K,Yanagihara H,Hayashi Y,Takamura T,Kaneko S,Fujimura A　Clin Exp Hypertens　31　3　201-7　2009/05
  • 　Palmitate induces insulin resistance in H4IIEC3 hepatocytes through reactive oxygen species produced by mitochondria.　Nakamura S,Takamura T,Matsuzawa-Nagata N,Takayama H,Misu H,Noda H,Nabemoto S,Kurita S,Ota T,Ando H,Miyamoto K,Kaneko S　J Biol Chem　284　22　14809-18　2009/05
  • 　Middle-aged Japanese women are resistant to obesity-related metabolic abnormalities.　Sakurai M,Takamura T,Miura K,Kaneko S,Nakagawa H　Metabolism　58　4　456-9　2009/04
  • 　The hepatic circadian clock is preserved in a lipid-induced mouse model of non-alcoholic steatohepatitis.　Ando H,Takamura T,Matsuzawa-Nagata N,Shima KR,Nakamura S,Kumazaki M,Kurita S,Misu H,Togawa N,Fukushima T,Fujimura A,Kaneko S　Biochem Biophys Res Commun　380　3　684-8　2009/03
  • 　Dietary glycemic index and risk of type 2 diabetes mellitus in middle-aged Japanese men.　Sakurai M,Nakamura K,Miura K,Takamura T,Yoshita K,Morikawa Y,Ishizaki M,Kido T,Naruse Y,Suwazono Y,Kaneko S,Sasaki S,Nakagawa H　Metabolism　2010/01
  • 　Histological course of nonalcoholic fatty liver disease in Japanese patients: tight glycemic control, rather than weight reduction, ameliorates liver fibrosis.　Hamaguchi E,Takamura T,Sakurai M,Mizukoshi E,Zen Y,Takeshita Y,Kurita S,Arai K,Yamashita T,Sasaki M,Nakanuma Y,Kaneko S　DIABETES CARE　33　2　284-6　2010/02
  • 　Influence of age on clock gene expression in peripheral blood cells of healthy women.　Ando H,Ushijima K,Kumazaki M,Takamura T,Yokota N,Saito T,Irie S,Kaneko S,Fujimura A　J Gerontol A Biol Sci Med Sci　65　1　9-13　2008/01
  • 　Abnormal liver function tests and metabolic syndrome--is fatty liver related to risks for atherosclerosis beyond obesity?　Sakurai M,Takamura T,Miura K,Kaneko S,Nakagawa H　Intern Med　48　18　1573-4　2009
  • 　Dietary glycemic index and risk of type 2 diabetes mellitus in middle-aged Japanese men.　Sakurai M,Nakamura K,Miura K,Takamura T,Yoshita K,Morikawa Y,Ishizaki M,Kido T,Naruse Y,Suwazono Y,Kaneko S,Sasaki S,Nakagawa H　Metabolism　2012/01
  • 　Altered hepatic gene expression profiles associated with myocardial ischemia.　Ootsuji H,Honda M,Kaneko S,Usui S,Okajima M,Okada H,Sakai Y,Takamura T,Horimoto K,Takamura M　Circ Cardiovasc Genet　3　1　68-77　2010/02
  • 　Associations of metabolic parameters and ethanol consumption with messenger RNA expression of clock genes in healthy men.　Ando H,Ushijima K,Kumazaki M,Eto T,Takamura T,Irie S,Kaneko S,Fujimura A　Chronobiol Int　27　1　194-203　2010/01
  • 　Effect of pioglitazone on muscle sympathetic nerve activity in type 2 diabetes mellitus with α-glucosidase inhibitor.　Kobayashi D,Takamura M,Murai H,Usui S,Ikeda T,Inomata J,Takashima S,Kato T,Furusho H,Takeshita Y,Ota T,Takamura T,Kaneko S　Auton Neurosci　158　1-2　86-91　2010/12
  • 　Transient anti-GAD antibody positivity and acute pancreatitis with pancreas tail swelling in a patient with susceptible haplotype for type 1 diabetes mellitus.　Kahara T,Takamura T,Otoda T,Ishikura K,Matsushita E　Intern Med　48　21　1897-9　2009
  • 　Characteristics of patients with nonalcoholic steatohepatitis who develop hepatocellular carcinoma.　Yasui K,Hashimoto E,Komorizono Y,Koike K,Arii S,Imai Y,Shima T,Kanbara Y,Saibara T,Mori T,Kawata S,Uto H,Takami S,Sumida Y,Takamura T,Kawanaka M,Okanoue T,Japan NASH Study Group, Ministry of Health, Labour, and Welfare of Japan　Clin Gastroenterol Hepatol　9　5　428-33; quiz e50　2011/05
  • 　[The cutting-edge of medicine; clinical and molecular pathology of type 2 diabetic liver].　Takamura T,Misu H,Kaneko S　Nihon Naika Gakkai Zasshi　100　6　1670-6　2011/06
  • 　 Development of a Sol Particle Homogeneous Immunoassay for Measuring Full-Length Selenoprotein P in Human Serum. 　Tanaka M, Saito Y, Misu H, Kato S, Kita Y, Takeshita Y, Kanamori T, Nagano T, Nakagen M, Urabe T, Takamura T, Kaneko S, Takahashi K, Matsuyama N.　J Clin Lab Anal.　30　2　114-122　2016/03
  • 　EARTH study group.. Effects of long-term androgen replacement therapy on the physical and mental statuses of aging males with late-onset hypogonadism: a multicenter randomized controlled trial in Japan (EARTH Study).　Konaka H, Sugimoto K, Orikasa H, Iwamoto T, Takamura T, Takeda Y, Shigehara K, Iijima M, Koh E, Namiki M　 Asian J Androl. 　18　1　25-34　2016/01
  • 　 Liver steatosis is associated with insulin resistance in skeletal muscle rather than in the liver in Japanese patients with non-alcoholic fatty liver disease. 　Kato K, Takeshita Y, Misu H, Zen Y, Kaneko S, Takamura T.　J Diabetes Investig.　6　2　158-163　2015/03
  • 　Establishment of Rationale for Antiaging Diabetic Medicine (ERA-DM) Study Chapter 2 Group.. Vildagliptin vs liraglutide as a second-line therapy switched from sitagliptin-based regimens in patients with type 2 diabetes: A randomized, parallel-group study.　Takeshita Y, Takamura T, Kita Y, Otoda T, Kato K, Wakakuri H, Yamada M, Misu H, Matsushima Y, Kaneko S　 J Diabetes Investig. 　6　2　192-200　2015/03
  • 　 Whole exome sequencing combined with integrated variant annotation prediction identifies asymptomatic Tangier disease with compound heterozygous mutations in ABCA1 gene. 　Tada H, Kawashiri MA, Nohara A, Saito R, Tanaka Y, Nomura A, Konno T, Sakata K, Fujino N, Takamura T, Inazu A, Mabuchi H, Yamagishi M, Hayashi K.　Atherosclerosis.　240　2　324-329　2015/01
  • 　 Physiological roles of peroxido-vanadium complexes: Leitmotif as their signal transduction pathway. 　Matsugo S, Kanamori K, Sugiyama H, Misu H, Takamura T.　J Inorg Biochem.　147　93-98　2015/06
  • 　Renoprotective effects of atorvastatin compared with pravastatin on progression of early diabetic nephropathy. 　Takazakura A, Sakurai M, Bando Y, Misu H, Takeshita Y, Kita Y, Shimizu A, Hayakawa T, Kato K, Kaneko S, Takamura T. 　J Diabetes Investig.　6　3　346-353　2015/05
  • 　Once-weekly glucagon-like peptide-1 receptor agonist dulaglutide is non-inferior to once-daily liraglutide and superior to placebo in Japanese patients with type 2 diabetes: a 26-week randomized phase III study.　Miyagawa J, Odawara M, Takamura T, Iwamoto N, Takita Y, Imaoka T.　 Diabetes Obes Metab　17　10　974-983　2015/10
  • 　Sitagliptin versus mitiglinide switched from mealtime dosing of a rapid-acting insulin analog in patients with type 2 diabetes: a randomized, parallel-group study.　Takeshita Y, Takamura T, Kita Y, Takazakura A, Kato K, Isobe Y, Kaneko S.　 BMJ Open Diabetes Res Care. 　3　1　e000122-　2015/08
  • 　Bending of a vertical cannula without alarm during insulin pump therapy as a cause of unexpected hyperglycemia: A Japanese issue? 　Kuroda K, Takeshita Y, Kaneko S, Takamura T.　J Diabetes Investig.　6　6　739-740　2015/11
  • 　Once-weekly glucagon-like peptide-1 receptor agonist dulaglutide significantly decreases glycated haemoglobin compared with once-daily liraglutide in Japanese patients with type 2 diabetes: 52 weeks of treatment in a randomized phase III study.　Odawara M, Miyagawa J, Iwamoto N, Takita Y, Imaoka T, Takamura T. 　Diabetes Obes Metab.　18　3　249-257　2016/03
  • 　Pleiotropic effects of sitagliptin versus voglibose in patients with type 2 diabetes inadequately controlled via diet and/or a single oral antihyperglycemic agent: a multicenter, randomized trial.　 Matsushima Y, Takeshita Y, Kita Y, Otoda T, Kato K, Toyama-Wakakuri H, Akahori H, Shimizu A, Hamaguchi E, Nishimura Y, Kanamori T, Kaneko S, Takamura T.　 BMJ Open Diabetes Res Care.　4　1　e000190　2016/04
  • 　Dietary carbohydrate intake, presence of obesity and the incident risk of type 2 diabetes in Japanese men. 　 Sakurai M, Nakamura K, Miura K, Takamura T, Yoshita K, Nagasawa SY, Morikawa Y, Ishizaki M, Kido T, Naruse Y, Nakashima M, Nogawa K, Suwazono Y, Sasaki S, Nakagawa H. 　J Diabetes Investig. 　7　3　343-351　2016/05/07
  • 　Fat-free mass and calf circumference as body composition indices to determine non-exercise activity thermogenesis in patients with diabetes. 　Isobe Y, Sakurai M, Kita Y, Takeshita Y, Misu H, Kaneko S, Takamura T. 　J Diabetes Investig. 　7　3　352-358　2016/05/07
  • 　Rapid response of the steatosis-sensing hepatokine LECT2 during diet-induced weight cycling in mice. 　Chikamoto K, Misu H, Takayama H, Kikuchi A, Ishii KA, Lan F, Takata N, Tajima-Shirasaki N, Takeshita Y, Tsugane H, Kaneko S, Matsugo S, Takamura T.　Biochem Biophys Res Commun. 　478　3　1310-1316　2016/09/23
  • 　Where does liver fat go? A possible molecular link between fatty liver and diabetes. 　 Kikuchi A, Takamura T. 　J Diabetes Investig. 　2016/08
  • 　Development of a Sol Particle Homogeneous Immunoassay for Measuring Full-Length Selenoprotein P in Human Serum　Tanaka, Mutsumi; Saito, Yoshiro; Misu, Hirofumi; Kato, Seiji; Kita, Yuki; Takeshita, Yumie; Kanamori, Takehiro; Nagano, Toru; Nakagen, Masatoshi; Urabe, Takeshi; Takamura, Toshinari; Kaneko, Shuichi; Takahashi, Kazuhiko; Matsuyama, Naoto　Journal of Clinical Laboratory Analysis　2015/01/01　
  • 　Ectopic fat accumulation and distant organ-specific insulin resistance in Japanese people with nonalcoholic fatty liver disease　Kato, Kenichiro; Takamura, Toshinari; Takeshita, Yumie; Ryu, Yasuji; Misu, Hirofumi; Ota, Tsuguhito; Tokuyama, Kumpei; Nagasaka, Shoichiro; Matsuhisa, Munehide; Matsui, Osamu; Kaneko, Shuichi　PLoS ONE　9　3　2014/03/20　
  • 　Fatty liver as a consequence and cause of insulin resistance: Lessons from type 2 diabetic liver　Takamura, Toshinari; Misu, Hirofumi; Ota, Tsuguhito; Kaneko, Shuichi　Endocrine Journal　59　9　745-763　2012/10/31　
  • 　Clinicopathological features of liver injury in patients with type 2 diabetes mellitus and comparative study of histologically proven nonalcoholic fatty liver diseases with or without type 2 diabetes mellitus　Shima, Toshihide; Uto, Hirofumi; Ueki, Kohjiro; Takamura, Toshinari; Kohgo, Yutaka; Kawata, Sumio; Yasui, Kohichiroh; Park, Hyohun; Nakamura, Naoto; Nakatou, Tatsuaki; Tanaka, Nobuyoshi; Umemura, Atsushi; Mizuno, Masayuki; Tanaka, Junko; Okanoue, Takeshi　Journal of Gastroenterology　48　4　515-525　2013/04/01　
  • 　[Novel strategies that target hepatokines for treatment of type 2 diabetes].　Misu, Hirofumi; Takamura, Toshinari; Kaneko, Shuichi　Nihon rinsho. Japanese journal of clinical medicine　70　1　157-163　2012/01/01　
  • 　Beneficial effect of branched-chain amino acid supplementation on glycemic control in chronic hepatitis C patients with insulin resistance: Implications for type 2 diabetes　Takeshita, Yumie; Takamura, Toshinari; Kita, Yuki; Ando, Hitoshi; Ueda, Teruyuki; Kato, Kenichiro; Misu, Hirofumi; Sunagozaka, Hajime; Sakai, Yoshio; Yamashita, Tatsuya; Mizukoshi, Eishiro; Honda, Masao; Kaneko, Shuichi　Metabolism: Clinical and Experimental　61　10　1388-1394　2012/10/01　
  • 　[Diabetes mellitus related common medical disorders: recent progress in diagnosis and treatment. Topics: I. Pathophysiology, diagnosis and treatment; 1. Nonalcoholic fatty liver disease].　Takamura, Toshinari　Nihon Naika Gakkai zasshi. The Journal of the Japanese Society of Internal Medicine　102　4　836-844　2013/04/10　
  • 　Association between coefficients of variation of the R-R intervals on electrocardiograms and post-challenge hyperglycemia in patients with newly diagnosed type 2 diabetes　Nakade, Yusuke; Takamura, Toshinari; Sakurai, Masaru; Misu, Hirofumi; Nagata, Mitsuko; Nanbu, Yuko; Oe, Hiroyasu; Takamura, Toshiji; Sakai, Yoshio; Kaneko, Shuichi; Wada, Takashi　Journal of Diabetes Investigation　2　4　324-327　2011/08/01　
  • 　Development of the automated gold-linked electrochemical immunoassay system for blood monitoring　Shiohara, Suguru; Chikae, Miyuki; Ukita, Yoshiaki; Ushijima, Hiromi; Fukumura, Yasukazu; Takamura, Toshinari; Takamura, Yuzuru　Microsystem Technologies　20　2　273-279　2014/02/01　
  • 　Dosing time-dependent effect of raloxifene on plasma plasminogen activator inhibitor-1 concentrations in post-menopausal women with osteoporosis　Ando, Hitoshi; Otoda, Toshiki; Ookami, Hitoshi; Nagai, Yukihiro; Inano, Akihiro; Takamura, Toshinari; Ushijima, Kentarou; Hosohata, Keiko; Matsushita, Eiki; Saito, Tetsuo; Kaneko, Shuichi; Fujimura, Akio　Clinical and Experimental Pharmacology and Physiology　40　3　227-232　2013/03/01　
  • 　Duodenal adenocarcinoma with neuroendocrine features in a patient with acromegaly and thyroid papillary adenocarcinoma: A unique combination of endocrine neoplasia　Kato, Kenichiro; Takeshita, Yumie; Misu, Hirofumi; Ishikura, Kazuhide; Kakinoki, Kaheita; Sawada-Kitamura, Seiko; Kaneko, Shuichi; Takamura, Toshinari　Endocrine Journal　59　9　791-796　2012/10/31　
  • 　Metformin Prevents and Reverses Inflammation in a Non-Diabetic Mouse Model of Nonalcoholic Steatohepatitis　Kita, Yuki; Takamura, Toshinari; Misu, Hirofumi; Ota, Tsuguhito; Kurita, Seiichiro; Takeshita, Yumie; Uno, Masafumi; Matsuzawa-Nagata, Naoto; Kato, Kenichiro; Ando, Hitoshi; Fujimura, Akio; Hayashi, Koji; Kimura, Toru; Ni, Yinhua; Otoda, Toshiki; Miyamoto, Kenichi; Zen, Yoh; Nakanuma, Yasuni; Kaneko, Shuichi　PLoS ONE　7　9　2012/09/18　
  • 　Postoperative diabetes insipidus associated with pituitary apoplexy during pregnancy　Kita, Daisuke; Hayashi, Yasuhiko; Sano, Hiroki; Takamura, Toshinari; Hayashi, Yutaka; Tachibana, Osamu; Hamada, Junichiro　Neuroendocrinology Letters　33　2　107-112　2012/06/20　
  • 　Quantitative analysis of hepatic fat fraction by single-breath-holding MR spectroscopy with T 2 correction: Phantom and clinical study with histologic assessment　Hayashi, Norio; Miyati, Tosiaki; Minami, Takashi; Takeshita, Yumie; Ryu, Yasuji; Matsuda, Tsuyoshi; Ohno, Naoki; Hamaguchi, Takashi; Kato, Kenichiro; Takamura, Toshinari; Matsui, Osamu　Radiological Physics and Technology　6　1　219-225　2013/01/01　
  • 　The effects of ezetimibe on non-alcoholic fatty liver disease and glucose metabolism: A randomised controlled trial　Takeshita, Yumie; Takamura, Toshinari; Honda, Masao; Kita, Yuki; Zen, Yoh; Kato, Kenichiro; Misu, Hirofumi; Ota, Tsuguhito; Nakamura, Mikiko; Yamada, Kazutoshi; Sunagozaka, Hajime; Arai, Kuniaki; Yamashita, Tatsuya; Mizukoshi, Eishiro; Kaneko, Shuichi　Diabetologia　57　5　878-890　2014/01/01　
  • 　Characteristics of Patients With Nonalcoholic Steatohepatitis Who Develop Hepatocellular Carcinoma　Yasui, Kohichiroh;Hashimoto, Etsuko;Komorizono, Yasuji;Koike, Kazuhiko;Arii, Shigeki;Imai, Yasuharu;Shima, Toshihide;Kanbara, Yoshihiro;Saibara, Toshiji;Mori, Takahiro;Kawata, Sumio;Uto, Hirofumi;Takami, Shiro;Sumida, Yoshio;Takamura, Toshinari;Kawanaka, Miwa;Okanoue, Takeshi;Japan NASH Study Grp;Minist Hlth Labour & Welfare Japan　CLINICAL GASTROENTEROLOGY AND HEPATOLOGY　9　5　428-433　2011
  • 　Characteristics of hepatic fatty acid compositions in patients with nonalcoholic steatohepatitis　Yamada, Kazutoshi;Mizukoshi, Eishiro;Sunagozaka, Hajime;Arai, Kuniaki;Yamashita, Tatsuya;Takeshita, Yumie;Misu, Hirofumi;Takamura, Toshinari;Kitamura, Seiko;Zen, Yoh;Nakanuma, Yasuni;Honda, Masao;Kaneko, Shuichi　LIVER INTERNATIONAL　35　2　582-590　2015/01/01　
  • 　Inverse correlation between serum levels of selenoprotein p and adiponectin in patients with type 2 diabetes　Misu, Hirofumi; Ishikura, Kazuhide; Kurita, Seiichiro; Takeshita, Yumie; Ota, Tsuguhito; Saito, Yoshiro; Takahashi, Kazuhiko; Kaneko, Shuichi; Takamura, Toshinari　PLoS ONE　7　4　2012/04/04　
  • 　Urinary Kim-1 is a sensitive biomarker for the early stage of diabetic nephropathy in Otsuka Long-Evans Tokushima Fatty rats　Hosohata, Keiko; Ando, Hitoshi; Takeshita, Yumie; Misu, Hirofumi; Takamura, Toshinari; Kaneko, Shuichi; Fujimura, Akio　Diabetes and Vascular Disease Research　11　4　243-250　2014/01/01　
  • 　Remodeling of nutrient homeostasis by unfolded protein response　Takamura, Toshinari　Diabetes　63　3　841-843　2014/03/01　
  • 　Clinicopathological features of liver injury in patients with type 2 diabetes mellitus and comparative study of histologically proven nonalcoholic fatty liver diseases with or without type 2 diabetes mellitus　Shima, Toshihide;Uto, Hirofumi;Ueki, Kohjiro;Takamura, Toshinari;Kohgo, Yutaka;Kawata, Sumio;Yasui, Kohichiroh;Park, Hyohun;Nakamura, Naoto;Nakatou, Tatsuaki;Tanaka, Nobuyoshi;Umemura, Atsushi;Mizuno, Masayuki;Tanaka, Junko;Okanoue, Takeshi　JOURNAL OF GASTROENTEROLOGY　48　4　515-525　2013　
  • 　Association between coefficients of variation of the R-R intervals on electrocardiograms and post-challenge hyperglycemia in patients with newly diagnosed type 2 diabetes　Nakade, Yusuke;Takamura, Toshinari;Sakurai, Masaru;Misu, Hirofumi;Nagata, Mitsuko;Nanbu, Yuko;Oe, Hiroyasu;Takamura, Toshiji;Sakai, Yoshio;Kaneko, Shuichi;Wada, Takashi　JOURNAL OF DIABETES INVESTIGATION　2　4　324-327　2011
  • 　Selenoprotein P as a diabetes-associated hepatokine that impairs angiogenesis by inducing VEGF resistance in vascular endothelial cells　Ishikura, Kazuhide; Misu, Hirofumi; Kumazaki, Masafumi; Takayama, Hiroaki; Matsuzawa-Nagata, Naoto; Tajima, Natsumi; Chikamoto, Keita; Lan, Fei; Ando, Hitoshi; Ota, Tsuguhito; Sakurai, Masaru; Takeshita, Yumie; Kato, Kenichiro; Fujimura, Akio; Miyamoto, Kenichi; Saito, Yoshiro; Kameo, Satomi; Okamoto, Yasuo; Takuwa, Yoh; Takahashi, Kazuhiko; Kidoya, Hiroyasu; Takakura, Nobuyuki; Kaneko, Shuichi; Takamura, Toshinari　Diabetologia　57　9　1968-1976　2014/01/01　
  • 　Genetic variants in selenoprotein P plasma 1 gene (SEPP1) are associated with fasting insulin and first phase insulin response in Hispanics　Hellwege, Jacklyn N.; Palmer, Nicholette D.; Ziegler, Julie T.; Langefeld, Carl D.; Lorenzo, Carlos; Norris, Jill M.; Takamura, Toshinari; Bowden, Donald W.　Gene　534　1　33-39　2014/01/15　
  • 　Identification of blood biomarkers of aging by transcript profiling of whole blood　Nakamura, Seiji; Kawai, Kozo; Takeshita, Yumie; Honda, Masao; Takamura, Toshinari; Kaneko, Shuichi; Matoba, Ryo; Matsubara, Kenichi　Biochemical and Biophysical Research Communications　418　2　313-318　2012/02/10　
  • 　Pharmacokinetics and pharmacodynamics of insulin aspart in patients with Type 2 diabetes: Assessment using a meal tolerance test under clinical conditions　Ando, Hitoshi; Kurita, Seiichiro; Shimizu, Akiko; Kato, Kenichiro; Ishikura, Kazuhide; Taji, Koumei; Uno, Masafumi; Takeshita, Yumie; Misu, Hirofumi; Fujimura, Akio; Kaneko, Shuichi; Takamura, Toshinari　Clinical and Experimental Pharmacology and Physiology　39　6　528-534　2012/06/01　
  • 　Long-term outcomes of japanese type 2 diabetic patients with biopsy-proven diabetic nephropathy　Shimizu, Miho; Furuichi, Kengo; Toyama, Tadashi; Kitajima, Shinji; Hara, Akinori; Kitagawa, Kiyoki; Iwata, Yasunori; Sakai, Norihiko; Takamura, Toshinari; Yoshimura, Mitsuhiro; Yokoyama, Hitoshi; Kaneko, Shuichi; Wada, Takashi　Diabetes Care　36　11　3655-3662　2013/11/01　
  • 　Marked improvement of insulin resistance after weight loss by diet and exercise therapy in an obese diabetic patient with charcot-marie-tooth disease　Kanamori, Takehiro; Takeshita, Yumie; Misu, Hirofumi; Kato, Kenichiro; Ota, Tsuguhito; Kaneko, Shuichi; Takamura, Toshinari　Journal of the Japan Diabetes Society　55　10　803-808　2012/10/01　
  • 　Genetic polymorphisms of the human PNPLA3 gene are strongly associated with severity of non-alcoholic fatty liver disease in Japanese　Kawaguchi, Takahisa; Sumida, Yoshio; Umemura, Atsushi; Matsuo, Keitaro; Takahashi, Meiko; Takamura, Toshinari; Yasui, Kohichiroh; Saibara, Toshiji; Hashimoto, Etsuko; Kawanaka, Miwa; Watanabe, Sumio; Kawata, Sumio; Imai, Yasuharu; Kokubo, Miki; Shima, Toshihide; Park, Hyohun; Tanaka, Hideo; Tajima, Kazuo; Yamada, Ryo; Matsuda, Fumihiko; Okanoue, Takeshi　PLoS ONE　7　6　2012/06/14　

Conference Presentations

  • Efficacy and Safety of Once-weekly Dulaglutide versus Once-daily Liraglutide in Japanese patients with Type 2 Diabetes(conference：75th Scientific Sessions American Diabetes Association (ADA))(2015/06/04)
  • 篁　俊成

Others

  • 　Transgenic mice overexpressing type 2 nitric-oxide synthase in pancreatic beta cells develop insulin-dependent diabetes without insulitis　273　5　2493　1998/01

Arts and Fieldwork

Patent

○Candidate genes coding liver-derived secretory proteins associated with type 2 diabetes and obesity

Theme to the desired joint research

○Pathology of diabetes, obesity and fatty liver
○Functional analyses of hepatokines (selenoprotein P, LECT2)
○Molecular pathology of insulin resistance

Grant-in-Aid for Scientific Research

○「細胞内蛋白分解系のエネルギー代謝恒常性維持における統合的役割の解明」(2014-2016)
○「内分泌器官としての肝臓病学の確立」(2014-2018)　
○「肥満による肝インスリン抵抗性形成におけるプロテアソーム機能異常の意義」(2011-2013)　
○「セレノプロテインＰ測定試薬の開発－インスリン抵抗性バイオマーカーを用いた糖尿病の予防・治療への応用」(2011-2013)　
○「過栄養状態の肝臓が産生するタンパクと生活習慣病の関連」(2011-2013)　
○「インスリン抵抗性と血管合併症を形成する肝臓由来新規ホルモンの機能解析」(2008-2010)　
○「過栄養状態における肝臓機能の破綻と生活習慣病の研究」(2006-2010)　
○「2型糖尿病患者の肝臓における酸化的リン酸化を制御するマスター遺伝子の同定」(2005-)　
○「胚シグナルに対する免疫応答異常を共通の病因とする新しい疾患群の同定と解析」(2019-2020)　
○「肝臓-骨格筋連関を標的とした運動効果増強薬の開発」(2018-2020)　
○「酸化・還元バランスの破綻による糖尿病病態形成機構の解明」(2017-2021)　

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

○Endocrinology & Metabolism(2017)
○Endocrinology & Metabolism(2016)

Classes (Graduate Schools)

○Environment and Health -Introductory(2017)
○Comprehensive Metabology(2017)
○Comprehensive Metabology(2017)
○Comprehensive Metabology(2017)
○omics(2017)
○Environment and Heredity(2017)
○Disease and Nutrient Metabolism(2017)
○Topics in Biochemical Engineering 1(2017)
○Introduction to Medicine(2017)
○Introduction to Medicine(2016)
○Topics in Biochemical Engineering 1(2016)
○Environment and Heredity(2016)
○Disease and Nutrient Metabolism(2016)
○Comprehensive Metabology(2016)
○Environment and Health -Introductory(2016)
○Comprehensive Metabology(2016)
○Comprehensive Metabology(2016)

International Project

○WHO Consultation on Advancing Universal Health Coverage and the Future Research Directions of the WHO Centre for Health DevelopmentWHO(20141114-20141114)WHO Consultation on Advancing Universal Health Coverage and the Future Research Directions of the WHO Centre for Health Development

International Students

Lecture themes

Others (Social Activities)

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