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Researcher Information

last modified：2024/11/21

Professor　Akihiro Nomura

Mail Laboratory Website
Laboratory Website

Faculty, Affiliation

Faculty of Transdisciplinary Sciences, Institute of Philosophy in Interdisciplinary Sciences　Department of Cardiovascular Medicine
Professor

College and School Educational Field

Division of Cardiovascular Medicine, Graduate School of Medical Science
College of Transdisciplinary Sciences for Innovation
School of Medicine, College of Medical, Pharmaceutical and Health Sciences

Laboratory

Department of Cardiovascular Medicine

Academic Background

【Academic background(Doctoral/Master's Degree)】
Kanazawa University Graduate School of Medicine　Doctor　Department of Cardiovascular and Internal Medicine
【Academic background(Bachelor's Degree)】
Kanazawa University　200603
【Degree】
Ph.D.
M.D.

Career

Massachusetts General Hospital, Harvard Medical School　 Center for Genomic Medicine　Post-doc Research Fellow(2014/07/01-2016/09/30)
Kokura Memorial Hospital　Department of Cardiology　Staff(2010/04/01-2013/03/31)
St. Lukes International Hospital(2006/04/01-2010/03/31)

Year & Month of Birth

Academic Society

The Japanese Society of Internal Medicine
The Japanese Circulation Society
The Japanese Society of Hypertension
Japanese Telemedicine and Telecare Association
JSCTR

Award

JSCTR
JSCTR
JSCTR

Specialities

Cardiovascular medicine、Digital Medicine、Medical genome science

Speciality Keywords

Digital Therapeutics (DTx),Digital Medicine,Digital Health,Machine Learning,web3,XR,Telemedicine,Genetics and Genomics,Cardiology

Research Themes

Books

Papers

  • 　Association of Rare and Common Variation in the Lipoprotein Lipase Gene with Coronary Artery Disease.　Khera AV, Won HH, Peloso GM, O'Dushlaine C, Liu D, Stitziel NO, Natarajan P, Nomura A, Emdin CA, Gupta N, Borecki IB, Asselta R, Duga S, Merlini PA, Correa A, Kessler T, Wilson JG, Bown MJ, Hall AS, Braund PS, Carey DJ, Murray MF, Kirchner HL, Leader JB, Lavage DR, Manus JN, Hartzel DN, Samani NJ, Schunkert H, Marrugat J, Elosua R, McPherson R, Farrall M, Watkins H, Lander ES, Rader DJ, Danesh J, Ardissino D, Gabriel S, Willer C, Abecasis GR, Saleheen D, Dewey FE, Kathiresan S.　The Journal of the American Medical Association (JAMA). 2017 03 07; 317(9):937-946.
  • 　Phenotypic Characterization of Genetically Lowered Human Lipoprotein(a) Levels. 　Emdin CA, Khera AV, Natarajan P, Klarin D, Won HH, Peloso GM, Stitziel NO, Nomura A, Zekavat SM, Bick AG, Gupta N, Asselta R, Duga S, Merlini PA, Correa A, Kessler T, Wilson JG, Bown MJ, Hall AS, Braund PS, Samani NJ, Schunkert H, Marrugat J, Elosua R, McPherson R, Farrall M, Watkins H, Willer C, Abecasis GR, Felix JF, Vasan RS, Lander E, Rader DJ, Danesh J, Ardissino D, Gabriel S, Saleheen D, Kathiresan S.　Journal of the American College of Cardiology. 2016 Dec 27; 68(25):2761-2772.
  • 　Impact of Baseline Angiographic Complexities Determined by Coronary Artery Bypass Grafting SYNTAX Score on the Prediction of Outcome After Percutaneous Coronary Intervention. 　Nakahashi T, Sakata K, Nomura A, Yakuta Y, Gamou T, Terai H, Horita Y, Ikeda M, Namura M, Takamura M, Kawashiri MA, Yamagishi M, Hayashi K.　American Journal of Cardiology. 2016 Oct 1; 118(7):974-9.
  • 　Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals.　Eicher JD*, Chami N*, Kacprowski T*, Nomura A*, Chen MH, Yanek LR, Tajuddin SM, Schick UM, Slater AJ, Pankratz N, Polfus L, Schurmann C, Giri A, Brody JA, Lange LA, Manichaikul A, Hill WD, Pazoki R, Elliot P, Evangelou E, Tzoulaki I, Gao H, Vergnaud AC, Mathias RA, Becker DM, Becker LC, Burt A, Crosslin DR, Lyytikäinen LP, Nikus K, Hernesniemi J, Kähönen M, Raitoharju E, Mononen N, Raitakari OT, Lehtimäki T, Cushman M, Zakai NA, Nickerson DA, Raffield LM, Quarells R, Willer CJ, Peloso GM, Abecasis GR, Liu DJ, Global Lipids Genetics Consortium, Deloukas P, Samani NJ, Schunkert H, Erdmann J; CARDIoGRAM Exome Consortium; Myocardial Infarction Genetics Consortium, Fornage M, Richard M, Tardif JC, Rioux JD, Dube MP, de Denus S, Lu Y, Bottinger EP, Loos RJ, Smith AV, Harris TB, Launer LJ, Gudnason V, Velez Edwards DR, Torstenson ES, Liu Y, Tracy RP, Rotter JI, Rich SS, Highland HM, Boerwinkle E, Li J, Lange E, Wilson JG, Mihailov E, Mägi R, Hirschhorn J, Metspalu A, Esko T, Vacchi-Suzzi C, Nalls MA, Zonderman AB, Evans MK, Engström G, Orho-Melander M, Melander O, O'Donoghue ML, Waterworth DM, Wallentin L, White HD, Floyd JS, Bartz TM, Rice KM, Psaty BM, Starr JM, Liewald DC, Hayward C, Deary IJ, Greinacher A, Völker U, Thiele T, Völzke H, van Rooij FJ, Uitterlinden AG, Franco OH, Dehghan A, Edwards TL, Ganesh SK, Kathiresan S, Faraday N*, Auer PL*, Reiner AP*, Lettre G*, Johnson AD*. (*: Equal contribution)　American Journal of Human Genetics. 2016 Jul 07; 99(1):40-55.
  • 　Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits. 　Chami N, Chen MH, Slater AJ, Eicher JD, Evangelou E, Tajuddin SM, Love-Gregory L, Kacprowski T, Schick UM, Nomura A, Giri A, Lessard S, Brody JA, Schurmann C, Pankratz N, Yanek LR, Manichaikul A, Pazoki R, Mihailov E, Hill WD, Raffield LM, Burt A, Bartz TM, Becker DM, Becker LC, Boerwinkle E, Bork-Jensen J, Bottinger EP, O'Donoghue ML, Crosslin DR, de Denus S, Dubé MP, Elliott P, Engström G, Evans MK, Floyd JS, Fornage M, Gao H, Greinacher A, Gudnason V, Hansen T, Harris TB, Hayward C, Hernesniemi J, Highland HM, Hirschhorn JN, Hofman A, Irvin MR, Kähönen M, Lange E, Launer LJ, Lehtimäki T, Li J, Liewald DC, Linneberg A, Liu Y, Lu Y, Lyytikäinen LP, Mägi R, Mathias RA, Melander O, Metspalu A, Mononen N, Nalls MA, Nickerson DA, Nikus K, O'Donnell CJ, Orho-Melander M, Pedersen O, Petersmann A, Polfus L, Psaty BM, Raitakari OT, Raitoharju E, Richard M, Rice KM, Rivadeneira F, Rotter JI, Schmidt F, Smith AV, Starr JM, Taylor KD, Teumer A, Thuesen BH, Torstenson ES, Tracy RP, Tzoulaki I, Zakai NA, Vacchi-Suzzi C, van Duijn CM, van Rooij FJ, Cushman M, Deary IJ, Velez Edwards DR, Vergnaud AC, Wallentin L, Waterworth DM, White HD, Wilson JG, Zonderman AB, Kathiresan S, Grarup N, Esko T, Loos RJ, Lange LA, Faraday N, Abumrad NA, Edwards TL, Ganesh SK, Auer PL, Johnson AD, Reiner AP, Lettre G.　American Journal of Human Genetics. 2016 Jul 7; 99(1):8-21.

show all

  • 　Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia.　Khera AV, Won HH, Peloso GM, Lawson KS, Bartz TM, Deng X, van Leeuwen EM, Natarajan P, Emdin CA, Bick AG, Morrison AC, Brody JA, Gupta N, Nomura A, Kessler T, Duga S, Bis JC, van Duijn CM, Cupples LA, Psaty B, Rader DJ, Danesh J, Schunkert H, McPherson R, Farrall M, Watkins H, Lander E, Wilson JG, Correa A, Boerwinkle E, Merlini PA, Ardissino D, Saleheen D, Gabriel S, Kathiresan S.　Journal of the American College of Cardiology. 2016 Jun 7; 67(22):2578-89.
  • 　Usefulness of Electrocardiographic Voltage to Determine Myocardial Fibrosis in Hypertrophic Cardiomyopathy.　Konno T, Nagata Y, Teramoto R, Fujino N, Nomura A, Tada H, Sakata K, Furusho H, Takamura M, Nakamura H, Kawashiri MA, Yamagishi M, Hayashi K.　American Journal of Cardiology. 2016 Feb 1; 117(3):443-9.
  • 　Whole exome sequencing combined with integrated variant annotation prediction identifies a causative myosin essential light chain variant in hypertrophic cardiomyopathy.　Nomura A, Tada H, Teramoto R, Konno T, Hodatsu A, Won HH, Kathiresan S, Ino H, Fujino N, Yamagishi M, Hayashi K.　Journal of Cardiology. 2016 Feb; 67(2):133-9.
  • 　Electrocardiographic QRS Fragmentation as a Marker for Myocardial Fibrosis in Hypertrophic Cardiomyopathy.　Konno T, Hayashi K, Fujino N, Oka R, Nomura A, Nagata Y, Hodatsu A, Sakata K, Furusho H, Takamura M, Nakamura H, Kawashiri MA, Yamagishi M.　Journal of Cardiovascular Electrophysiology. 2015 Oct; 26(10):1081-7.
  • 　Successful endovascular treatment for high take off aorto-iliac occlusive disease.　Nomura A, Nagashima M, Tomoi Y, Tosaka A, Soga Y.　Internal Medicine. 2015; 54(8):921-4.
  • 　Whole exome sequencing combined with integrated variant annotation prediction identifies asymptomatic Tangier disease with compound heterozygous mutations in ABCA1 gene.　Tada H, Kawashiri MA, Nohara A, Saito R, Tanaka Y, Nomura A, Konno T, Sakata K, Fujino N, Takamura T, Inazu A, Mabuchi H, Yamagishi M, Hayashi K.　Atherosclerosis. 2015 Jun; 240(2):324-9.
  • 　Right Ventricular Hypertrophy is Associated with Cardiovascular Events in Hypertrophic Cardiomyopathy: Evidence from Study with Magnetic Resonance. 　Nagata Y, Konno T, Fujino N, Hodatsu A, Nomura A, Hayashi K, Nakamura H, Kawashiri MA, Yamagishi M.　Canadian Journal of Cardiology. 2015 Jun;31(6):702-8.
  • 　Fragmented QRS Predicts Heart Failure Progression in Patients With Hypertrophic Cardiomyopathy. 　Nomura A, Konno T, Fujita T, Tanaka Y, Nagata Y, Tsuda T, Hodatsu A, Sakata K, Nakamura H, Kawashiri MA, Fujino N, Yamagishi M, Hayashi K.　Circulation Journal. 2015;79:136-143.
  • 　Can next-generation sequencing replace sanger sequencing for screening genetic variant? 　Kawashiri MA, Nomura A, Konno T, Hayashi K.　Circulation Journal. 2014 Nov 25;78(12):2845-7.
  • 　Impact of clinical and echocardiographic characteristics on occurrence of cardiac events in cardiac amyloidosis as proven by endomyocardial biopsy. 　Nakahashi T, Arita T, Yamaji K, Inoue K, Yokota T, Hoshii Y, Fukunaga M, Nomura A, Watanabe H, Miura S, Isotani A, Soga Y, Ando K, Iwabuchi M, Yokoi H, Nosaka H, Yamagishi M, Nobuyoshi M.　International Journal of Cardiology. 2014 Oct 20;176(3):753-9. doi: 10.1016
  • 　Impact of post-challenge hyperglycemia on clinical outcomes in japanese patients with stable angina undergoing percutaneous coronary intervention. 　Kuramitsu S, Yokoi H, Domei T, Nomura A, Watanabe H, Yamaji K, Soga Y, Arita T, Kondo K, Shirai S, Ando K, Sakai K, Iwabuchi M, Nosaka H, Nobuyoshi M.　Cardiovascular Diabetology. 2013 May 7;12:74. doi: 10.1186/1475-2840-12-74.
  • 　Very long-term outcomes after percutaneous coronary intervention with bare metal stents for unprotected left main coronary artery disease. 　Nomura A, Yamaji K, Shirai S, Omata F, Soga Y, Nagashima M, Arita T, Ando K, Sakai K, Goya M, Yokoi H, Iwabuchi M, Nobuyoshi M.　EuroIntervention.  2012 Dec 20;8(8):962-9. doi: 10.4244/EIJV8I8A146.
  • 　Coexistence of visceral fat and multiple risk factor accumulations is strongly associated with coronary artery disease in Japanese (the VACATION-J study). 　Hiuge-Shimizu A, Kishida K, Funahashi T, Okutsu M, Kametani R, Kobayashi H, Nozaki Y, Nomura A, Yokoi H, Yoshizumi T, Ohira T, Nakamura T, Matsuzawa Y, Sumitsuji S, Shimomura I.　Journal of Atherosclerosis and Thrombosis. 2012;19(7):657-63. Epub 2012 May 4.
  • 　Risk factors of mid-term mortality of patients with infective endocarditis. 　Nomura A, Omata F, Furukawa K.　European Journal of Clinical Microbiology and Infectious Diseases, 29(11):1355-60, 2010.
  • 　Electrocardiographic QRS Fragmentation as a Marker for Myocardial Fibrosis in Hypertrophic Cardiomyopathy　Tetsuo Konno,Kenshi Hayashi,Noboru Fujino,Rie Oka,Akihiro Nomura,Yoji Nagata,Akihiko Hodatsu,Kenji Sakata,Hiroshi Furusho,Masayuki Takamura,Hiroyuki Nakamura,Masa-Aki Kawashiri,Masakazu Yamagishi　JOURNAL OF CARDIOVASCULAR ELECTROPHYSIOLOGY　26　10　1081　2015/10　
  • 　Impact of post-challenge hyperglycemia on clinical outcomes in Japanese patients with stable angina undergoing percutaneous coronary intervention.　Shoichi Kuramitsu,Hiroyoshi Yokoi,Takenori Domei,Akihiro Nomura,Hirotoshi Watanabe,Kyohei Yamaji,Yoshimitsu Soga,Takeshi Arita,Katsuhiro Kondo,Shinichi Shirai,Kenji Ando,Koyu Sakai,Masashi Iwabuchi,Hedeyuki Nosaka,Masakiyo Nobuyoshi　Cardiovascular diabetology　12　74　2013/05/07　
  • 　Successful Endovascular Treatment for High Take Off Aorto-iliac Occlusive Disease　Akihiro Nomura,Michio Nagashima,Yusuke Tomoi,Atsushi Tosaka,Yoshimitsu Soga　INTERNAL MEDICINE　54　8　921　2015　
  • 　Impact of clinical and echocardiographic characteristics on occurrence of cardiac events in cardiac amyloidosis as proven by endomyocardial biopsy.　Takuya Nakahashi,Takeshi Arita,Kyohei Yamaji,Katsumi Inoue,Tadaaki Yokota,Yoshinobu Hoshii,Masato Fukunaga,Akihiro Nomura,Hirotoshi Watanabe,Shirou Miura,Akihiro Isotani,Yoshimitsu Soga,Kenji Ando,Masashi Iwabuchi,Hiroyoshi Yokoi,Hideyuki Nosaka,Masakazu Yamagishi,Masakiyo Nobuyoshi　International journal of cardiology　176　3　753　2014/10/20　
  • 　Coexistence of Visceral Fat and Multiple Risk Factor Accumulations is Strongly Associated with Coronary Artery Disease in Japanese (The VACATION-J Study)　Aki Hiuge-Shimizu,Ken Kishida,Tohru Funahashi,Masaaki Okutsu,Ryosuke Kametani,Hiroshi Kobayashi,Yoichi Nozaki,Akihiro Nomura,Hiroyoshi Yokoi,Tohru Yoshizumi,Tetsuya Ohira,Tadashi Nakamura,Yuji Matsuzawa,Satoru Sumitsuji,Iichiro Shimomura　JOURNAL OF ATHEROSCLEROSIS AND THROMBOSIS　19　7　657　2012　
  • 　Whole exome sequencing combined with integrated variant annotation prediction identifies a causative myosin essential light chain variant in hypertrophic cardiomyopathy　Akihiro Nomura,Hayato Tada,Ryota Teramoto,Tetsuo Konno,Akihiko Hodatsu,Hong-Hee Won,Sekar Kathiresan,Hidekazu Ino,Noboru Fujino,Masakazu Yamagishi,Kenshi Hayashi　JOURNAL OF CARDIOLOGY　67　1-2　133　2016/01　
  • 　Whole exome sequencing combined with integrated variant annotation prediction identifies asymptomatic Tangier disease with compound heterozygous mutations in ABCA1 gene　Hayato Tada,Masa-aki Kawashiri,Atsushi Nohara,Reina Saito,Yoshihiro Tanaka,Akihiro Nomura,Tetsuo Konno,Kenji Sakata,Noboru Fujino,Toshinari Takamura,Akihiro Inazu,Hiroshi Mabuchi,Masakazu Yamagishi,Kenshi Hayashi　ATHEROSCLEROSIS　240　2　324　2015/06　
  • 　Fragmented QRS Predicts Heart Failure Progression in Patients With Hypertrophic Cardiomyopathy　Akihiro Nomura,Tetsuo Konno,Takashi Fujita,Yoshihiro Tanaka,Yoji Nagata,Toyonobu Tsuda,Akihiko Hodatsu,Kenji Sakata,Hiroyuki Nakamura,Masa-Aki Kawashiri,Noboru Fujino,Masakazu Yamagishi,Kenshi Hayashi　CIRCULATION JOURNAL　79　1　136　2015/01　
  • 　Risk factors of mid-term mortality of patients with infective endocarditis　A. Nomura,F. Omata,K. Furukawa　EUROPEAN JOURNAL OF CLINICAL MICROBIOLOGY & INFECTIOUS DISEASES　29　11　1355　2010/11　
  • 　Very long-term outcomes after percutaneous coronary intervention with bare metal stents for unprotected left main coronary artery disease　Akihiro Nomura,Kyohei Yamaji,Shinichi Shirai,Fumio Omata,Yoshimitsu Soga,Michio Nagashima,Takeshi Arita,Kenji Ando,Koyu Sakai,Masahiko Goya,Hiroyoshi Yokoi,Masashi Iwabuchi,Masakiyo Nobuyoshi　EUROINTERVENTION　8　8　962　2012/12　
  • 　Can Next-Generation Sequencing Replace Sanger Sequencing for Screening Genetic Variants?　Masa-aki Kawashiri,Akihiro Nomura,Tetsuo Konno,Kenshi Hayashi　CIRCULATION JOURNAL　78　12　2845　2014/12　
  • 　Right Ventricular Hypertrophy Is Associated With Cardiovascular Events in Hypertrophic Cardiomyopathy: Evidence From Study With Magnetic Resonance Imaging　Yoji Nagata,Tetsuo Konno,Noboru Fujino,Akihiko Hodatsu,Akihiro Nomura,Kenshi Hayashi,Hiroyuki Nakamura,Masa-Aki Kawashiri,Masakazu Yamagishi　CANADIAN JOURNAL OF CARDIOLOGY　31　6　702　2015/06　
  • 　Impact of Baseline Angiographic Complexities Determined by Coronary Artery Bypass Grafting SYNTAX Score on the Prediction of Outcome After Percutaneous Coronary Intervention　Takuya Nakahashi,Kenji Sakata,Akihiro Nomura,Yohei Yakuta,Tadatsugu Gamou,Hidenobu Terai,Yuki Horita,Masatoshi Ikeda,Masanobu Namura,Masayuki Takamura,Masa-aki Kawashiri,Masakazu Yamagishi,Kenshi Hayashi　AMERICAN JOURNAL OF CARDIOLOGY　118　7　974　2016/10　
  • 　Mendelian randomization: Its impact on cardiovascular disease　Masa-aki Kawashiri,Hayato Tada,Akihiro Nomura,Masakazu Yamagishi　Journal of Cardiology　72　307　2018　
  • 　J Waves for Predicting Cardiac Events in Hypertrophic Cardiomyopathy　Toyonobu Tsuda,Kenshi Hayashi,Tetsuo Konno,Kenji Sakata,Takashi Fujita,Akihiko Hodatsu,Yoji Nagata,Ryota Teramoto,Akihiro Nomura,Yoshihiro Tanaka,Hiroshi Furusho,Masayuki Takamura,Masa-aki Kawashiri,Noboru Fujino,Masakazu Yamagishi　JACC: Clinical Electrophysiology　3　10　1136　2017/10/01　
  • 　Association of Rare and Common Variation in the Lipoprotein Lipase Gene With Coronary Artery Disease　Amit V. Khera,Hong-Hee Won,Gina M. Peloso,Colm O'Dushlaine,Dajiang Liu,Nathan O. Stitziel,Pradeep Natarajan,Akihiro Nomura,Connor A. Emdin,Namrata Gupta,Ingrid B. Borecki,Rosanna Asselta,Stefano Duga,Piera Angelica Merlini,Adolfo Correa,Thorsten Kessler,James G. Wilson,Matthew J. Bown,Alistair S. Hall,Peter S. Braund,David J. Carey,Michael F. Murray,H. Lester Kirchner,Joseph B. Leader,Daniel R. Lavage,J. Neil Manus,Dustin N. Hartzel,Nilesh J. Samani,Heribert Schunkert,Jaume Marrugat,Roberto Elosua,Ruth McPherson,Martin Farrall,Hugh Watkins,Eric S. Lander,Daniel J. Rader,John Danesh,Diego Ardissino,Stacey Gabriel,Cristen Willer,Goncalo R. Abecasis,Danish Saleheen,Frederick E. Dewey,Sekar Kathiresan　JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION　317　9　937　2017/03　
  • 　Mortality and predictors of appropriate implantable cardioverter defibrillator therapy in Japanese patients with Multicenter Automatic Defibrillator Implantation Trial II criteria　Yoshimori An,Kenji Ando,Yoshimitsu Soga,Akihiro Nomura,Michio Nagashima,Kentaro Hayashi,Yu Makihara,Masato Fukunaga,Ken-ichi Hiroshima,Masakiyo Nobuyoshi,Masahiko Goya　Journal of Arrhythmia　33　1　17　2017/02/01　
  • 　Phenotypic Characterization of Genetically Lowered Human Lipoprotein(a) Levels　Connor A. Emdin,Amit V. Khera,Pradeep Natarajan,Derek Klarin,Hong-Hee Won,Gina M. Peloso,Nathan O. Stitziel,Akihiro Nomura,Seyedeh M. Zekavat,Alexander G. Bick,Namrata Gupta,Rosanna Asselta,Stefano Duga,Piera Angelica Merlini,Adolfo Correa,Thorsten Kessler,James G. Wilson,Matthew J. Bown,Alistair S. Hall,Peter S. Braund,Nilesh J. Samani,Heribert Schunkert,Jaume Marrugat,Roberto Elosua,Ruth McPherson,Martin Farrall,Hugh Watkins,Cristen Willer,Goncalo R. Abecasis,Janine F. Felix,Ramachandran S. Vasan,Eric Lander,Daniel J. Rader,John Danesh,Diego Ardissino,Stacey Gabriel,Danish Saleheen,Sekar Kathiresan　JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY　68　25　2761　2016/12　
  • 　Exome Genotyping Identifies Pleiotropic Variants Associated with Red Blood Cell Traits　Nathalie Chami,Ming-Huei Chen,Andrew J. Slater,John D. Eicher,Evangelos Evangelou,Salman M. Tajuddin,Latisha Love-Gregory,Tim Kacprowski,Ursula M. Schick,Akihiro Nomura,Ayush Giri,Samuel Lessard,Jennifer A. Brody,Claudia Schurmann,Nathan Pankratz,Lisa R. Yanek,Ani Manichaikul,Raha Pazoki,Evelin Mihailov,W. David Hill,Laura M. Raffield,Amber Burt,Traci M. Bartz,Diane M. Becker,Lewis C. Becker,Eric Boerwinkle,Jette Bork-Jensen,Erwin P. Bottinger,Michelle L. O'Donoghue,David R. Crosslin,Simon de Denus,Marie-Pierre Dube,Paul Elliott,Gunnar Engstrom,Michele K. Evans,James S. Floyd,Myriam Fornage,He Gao,Andreas Greinacher,Vilmundur Gudnason,Torben Hansen,Tamara B. Harris,Caroline Hayward,Jussi Hernesniemi,Heather M. Highland,Joel N. Hirschhorn,Albert Hofman,Marguerite R. Irvin,Mika Kahonen,Ethan Lange,Lenore J. Launer,Terho Lehtimaki,Jin Li,David C. M. Liewald,Allan Linneberg,Yongmei Liu,Yingchang Lu,Leo-Pekka Lyytikainen,Reedik Magi,Rasika A. Mathias,Olle Melander,Andres Metspalu,Nina Mononen,Mike A. Nalls,Deborah A. Nickerson,Kjell Nikus,Chris J. O'Donnell,Marju Orho-Melander,Oluf Pedersen,Astrid Petersmann,Linda Polfus,Bruce M. Psaty,Olli T. Raitakari,Emma Raitoharju,Melissa Richard,Kenneth M. Rice,Fernando Rivadeneira,Jerome I. Rotter,Frank Schmidt,Albert Vernon Smith,John M. Starr,Kent D. Taylor,Alexander Teumer,Betina H. Thuesen,Eric S. Torstenson,Russell P. Tracy,Ioanna Tzoulaki,Neil A. Zakai,Caterina Vacchi-Suzzi,Cornelia M. van Duijn,Frank J. A. van Rooij,Mary Cushman,Ian J. Deary,Digna R. Velez Edwards,Anne-Claire Vergnaud,Lars Wallentin,Dawn M. Waterworth,Harvey D. White,James G. Wilson,Alan B. Zonderman,Sekar Kathiresan,Niels Grarup,Tonu Esko,Ruth J. F. Loos,Leslie A. Lange,Nauder Faraday,Nada A. Abumrad,Todd L. Edwards,Santhi K. Ganesh,Paul L. Auer,Andrew D. Johnson,Alexander P. Reiner,Guillaume Lettre　AMERICAN JOURNAL OF HUMAN GENETICS　99　1　8　2016/07　
  • 　Platelet-Related Variants Identified by Exomechip Meta-analysis in 157,293 Individuals　John D. Eicher,Nathalie Chami,Tim Kacprowski,Akihiro Nomura,Ming-Huei Chen,Lisa R. Yanek,Salman M. Tajuddin,Ursula M. Schick,Andrew J. Slater,Nathan Pankratz,Linda Polfus,Claudia Schurmann,Ayush Giri,Jennifer A. Brody,Leslie A. Lange,Ani Manichaikul,W. David Hill,Raha Pazoki,Paul Elliot,Evangelos Evangelou,Ioanna Tzoulaki,He Gao,Anne-Claire Vergnaud,Rasika A. Mathias,Diane M. Becker,Lewis C. Becker,Amber Burt,David R. Crosslin,Leo-Pekka Lyytikainen,Kjell Nikus,Jussi Hernesniemi,Mika Kahonen,Emma Raitoharju,Nina Mononen,Olli T. Raitakari,Terho Lehtimaki,Mary Cushman,Neil A. Zakai,Deborah A. Nickerson,Laura M. Raffield,Rakale Quarells,Cristen J. Willer,Gina M. Peloso,Goncalo R. Abecasis,Dajiang J. Liu,Panos Deloukas,Nilesh J. Samani,Heribert Schunkert,Jeanette Erdmann,Myriam Fornage,Melissa Richard,Jean-Claude Tardif,John D. Rioux,Marie-Pierre Dube,Simon de Denus,Yingchang Lu,Erwin P. Bottinger,Ruth J. F. Loos,Albert Vernon Smith,Tamara B. Harris,Lenore J. Launer,Vilmundur Gudnason,Digna R. Velez Edwards,Eric S. Torstenson,Yongmei Liu,Russell P. Tracy,Jerome I. Rotter,Stephen S. Rich,Heather M. Highland,Eric Boerwinkle,Jin Li,Ethan Lange,James G. Wilson,Evelin Mihailov,Reedik Magi,Joel Hirschhorn,Andres Metspalu,Tonu Esko,Caterina Vacchi-Suzzi,Mike A. Nalls,Alan B. Zonderman,Michele K. Evans,Gunnar Engstrom,Marju Orho-Melander,Olle Melander,Michelle L. O'Donoghue,Dawn M. Waterworth,Lars Wallentin,Harvey D. White,James S. Floyd,Traci M. Bartz,Kenneth M. Rice,Bruce M. Psaty,J. M. Starr,David C. M. Liewald,Caroline Hayward,Ian J. Deary,Andreas Greinacher,Uwe Volker,Thomas Thiele,Henry Volzke,Frank J. A. van Rooij,Andre G. Uitterlinden,Oscar H. Franco,Abbas Dehghan,Todd L. Edwards,Santhi K. Ganesh,Sekar Kathiresan,Nauder Faraday,Paul L. Auer,Alex P. Reiner,Guillaume Lettre,Andrew D. Johnson　AMERICAN JOURNAL OF HUMAN GENETICS　99　1　40　2016/07　
  • 　Usefulness of Electrocardiographic Voltage to Determine Myocardial Fibrosis in Hypertrophic Cardiomyopathy　Tetsuo Konno,Yoji Nagata,Ryota Teramoto,Noboru Fujino,Akihiro Nomura,Hayato Tada,Kenji Sakata,Hiroshi Furusho,Masayuki Takamura,Hiroyuki Nakamura,Masa-aki Kawashiri,Masakazu Yamagishi,Kenshi Hayashi　AMERICAN JOURNAL OF CARDIOLOGY　117　3　443　2016/02　
  • 　Protein-Truncating Variants at the Cholesteryl Ester Transfer Protein Gene and Risk for Coronary Heart Disease　Akihiro Nomura,Hong-Hee Won,Amit V. Khera,Fumihiko Takeuchi,Kaoru Ito,Shane McCarthy,Connor A. Emdin,Derek Klarin,Pradeep Natarajan,Seyedeh M. Zekavat,Namrata Gupta,Gina M. Peloso,Ingrid B. Borecki,Tanya M. Teslovich,Rosanna Asselta,Stefano Duga,Piera A. Merlini,Adolfo Correa,Thorsten Kessler,James G. Wilson,Matthew J. Bown,Alistair S. Hall,Peter S. Braund,David J. Carey,Michael F. Murray,H. Lester Kirchner,Joseph B. Leader,Daniel R. Lavage,J. Neil Manus,Dustin N. Hartze,Nilesh J. Samani,Heribert Schunkert,Jaume Marrugat,Roberto Elosua,Ruth McPherson,Martin Farrall,Hugh Watkins,Jyh-Ming J. Juang,Chao A. Hsiung,Shih-Yi Lin,Jun-Sing Wang,Hayato Tada,Masa-aki Kawashiri,Akihiro Inazu,Masakazu Yamagishi,Tomohiro Katsuya,Eitaro Nakashima,Masahiro Nakatochi,Ken Yamamoto,Mitsuhiro Yokota,Yukihide Momozawa,Jerome I. Rotter,Eric S. Lander,Daniel J. Rader,John Danesh,Diego Ardissino,Stacey Gabriel,Cristen J. Willer,Goncalo R. Abecasis,Danish Saleheen,Michiaki Kubo,Norihiro Kato,Yii-Der Ida Chen,Frederick E. Dewey,Sekar Kathiresan　CIRCULATION RESEARCH　121　1　81　2017/06　
  • 　Randomized placebo-controlled double-blind phase II study of zaltoprofen for patients with diffuse-type and unresectable localized tenosynovial giant cell tumors: a study protocol.　Takeuchi A,Nomura A,Yamamoto N,Hayashi K,Igarashi K,Tandai S,Kawai A,Matsumine A,Miwa S,Nishida Y,Nakamura T,Terauchi R,Hoshi M,Kunisada T,Endo M,Yoshimura K,Murayama T,Tsuchiya H　BMC musculoskeletal disorders　20　1　68　2019/02
  • 　Additive prognostic value of carotid plaque score to enhance the age, creatinine, and ejection fraction score in patients with acute coronary syndrome　Takuya Nakahashi,Hayato Tada,Kenji Sakata,Akihiro Nomura,Miho Ohira,Mika Mori,Masayuki Takamura,Kenshi Hayashi,Masakazu Yamagishi,Masa Aki Kawashiri　Journal of Atherosclerosis and Thrombosis　25　709　2018/01/01　
  • 　Phenotype and Prognosis of the Lamin A/C Gene (LMNA) Mutation Carriers in Japan　Fujino N,Hayashi K,Sakata K,Nomura A,Kawashiri MA　Circ J.　82　11　2699　2018/10
  • 　First case of sitosterolemia caused by double heterozygous mutations in ABCG5 and ABCG8 genes　Hayato Tada,Akihiro Nomura,Masakazu Yamagishi,Masa aki Kawashiri　Journal of Clinical Lipidology　12　5　1164　2018/01/01　
  • 　Oral fat tolerance test for sitosterolemia and familial hypercholesterolemia: A study protocol　Akihiro Nomura,Akihiro Nomura,Hayato Tada,Atsushi Nohara,Masa Aki Kawashiri,Masakazu Yamagishi　Journal of Atherosclerosis and Thrombosis　25　741　2018/01/01　
  • 　DNA Sequence Variation in ACVR1C Encoding the Activin Receptor-Like Kinase 7 Influences Body Fat Distribution and Protects Against Type 2 Diabetes.　Emdin CA,Khera AV,Aragam K,Haas M,Chaffin M,Klarin D,Natarajan P,Bick A,Zekavat SM,Nomura A,Ardissino D,Wilson JG,Schunkert H,McPherson R,Watkins H,Elosua R,Bown MJ,Samani NJ,Baber U,Erdmann J,Gupta N,Danesh J,Saleheen D,Gabriel S,Kathiresan S　Diabetes　68　1　226　2019/01
  • 　Impact of b-type natriuretic peptide level on risk stratification of thromboembolism and death in patients with nonvalvular atrial fibrillation: The hokuriku-plus AF registry　Kenshi Hayashi,Toyonobu Tsuda,Akihiro Nomura,Noboru Fujino,Atsushi Nohara,Kenji Sakata,Tetsuo Konno,Chiaki Nakanishi,Hayato Tada,Yoji Nagata,Ryota Teramoto,Yoshihiro Tanaka,Masa-Aki Kawashiri,Masakazu Yamagishi,Hokuriku-Plus AF Registry Investigators　Circulation Journal　82　5　1271　2018　
  • 　Clinical whole exome sequencing in severe hypertriglyceridemia　Hayato Tada,Akihiro Nomura,Hirofumi Okada,Takuya Nakahashi,Tsuyoshi Nozue,Kenshi Hayashi,Atsushi Nohara,Kunimasa Yagi,Akihiro Inazu,Ichiro Michishita,Hiroshi Mabuchi,Masakazu Yamagishi,Masa-aki Kawashiri　Clinica Chimica Acta　488　31　2019/01
  • 　Paradoxical impact of decreased low-density lipoprotein cholesterol level at baseline on the long-term prognosis in patients with acute coronary syndrome　Takuya Nakahashi,Hayato Tada,Kenji Sakata,Yohei Yakuta,Yoshihiro Tanaka,Akihiro Nomura,Tadatsugu Gamou,Hidenobu Terai,Yuki Horita,Masatoshi Ikeda,Masanobu Namura,Masayuki Takamura,Kenshi Hayashi,Masakazu Yamagishi,Masa-aki Kawashiri　Heart and Vessels　33　7　695　2018/07/01　
  • 　Post-prandial Remnant Lipoprotein Metabolism in Sitosterolemia.　Tada H,Nomura A,Nohara A,Inazu A,Mabuchi H,Yamagishi M,Kawashiri MA　Journal of atherosclerosis and thrombosis　25　12　1188　2018/12
  • 　Oligogenic familial hypercholesterolemia, LDL cholesterol, and coronary artery disease.　Hayato Tada,Masa-aki Kawashiri,Akihiro Nomura,Ryota Teramoto,Kazuyoshi Hosomichi,Atsushi Nohara,Akihiro Inazu,Hiroshi Mabuchi,Atsushi Tajima,Masakazu Yamagishi　Journal of Clinical Lipidology　12　6　1436　2018/11
  • 　Serum triglycerides predict first cardiovascular events in diabetic patients with hypercholesterolemia and retinopathy.　Tada H,Kawashiri MA,Nomura A,Yoshimura K,Itoh H,Komuro I,Yamagishi M　European journal of preventive cardiology　25　17　1852　2018/11
  • 　Diagnostic Yield and Clinical Utility of Sequencing Familial Hypercholesterolemia Genes in Patients With Severe Hypercholesterolemia　Amit V. Khera,Hong-Hee Won,Gina M. Peloso,Kim S. Lawson,Traci M. Bartz,Xuan Deng,Elisabeth M. van Leeuwen,Pradeep Natarajan,Connor A. Emdin,Alexander G. Bick,Alanna C. Morrison,Jennifer A. Brody,Namrata Gupta,Akihiro Nomura,Thorsten Kessler,Stefano Duga,Joshua C. Bis,Cornelia M. van Duijn,L. Adrienne Cupples,Bruce Psaty,Daniel J. Rader,John Danesh,Heribert Schunkert,Ruth McPherson,Martin Farrall,Hugh Watkins,Eric Lander,James G. Wilson,Adolfo Correa,Eric Boerwinkle,Piera Angelica Merlini,Diego Ardissino,Danish Saleheen,Stacey Gabriel,Sekar Kathiresan　JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY　67　22　2578　2016/06　
  • 　Phenotypic consequences of a genetic predisposition to enhanced nitric oxide signaling　Connor A. Emdin,Connor A. Emdin,Connor A. Emdin,Amit V. Khera,Amit V. Khera,Amit V. Khera,Derek Klarin,Derek Klarin,Derek Klarin,Pradeep Natarajan,Pradeep Natarajan,Pradeep Natarajan,Seyedeh M. Zekavat,Seyedeh M. Zekavat,Seyedeh M. Zekavat,Akihiro Nomura,Akihiro Nomura,Akihiro Nomura,Mary Haas,Mary Haas,Mary Haas,Krishna Aragam,Krishna Aragam,Krishna Aragam,Diego Ardissino,Diego Ardissino,James G. Wilson,Heribert Schunkert,Ruth McPherson,Hugh Watkins,Hugh Watkins,Roberto Elosua,Roberto Elosua,Roberto Elosua,Matthew J. Bown,Nilesh J. Samani,Usman Baber,Jeanette Erdmann,Padhraig Gormley,Padhraig Gormley,Aarno Palotie,Aarno Palotie,Aarno Palotie,Nathan O. Stitziel,Namrata Gupta,John Danesh,John Danesh,John Danesh,Danish Saleheen,Stacey Gabriel,Sekar Kathiresan,Sekar Kathiresan,Sekar Kathiresan　Circulation　137　222　2018/01/01　
  • 　ANGPTL3 Deficiency and Protection Against Coronary Artery Disease　Nathan O. Stitziel,Amit V. Khera,Xiao Wang,Andrew J. Bierhals,A. Christina Vourakis,Alexandra E. Sperry,Pradeep Natarajan,Derek Klarin,Connor A. Emdin,Seyedeh M. Zekavat,Akihiro Nomura,Jeanette Erdmann,Heribert Schunkert,Nilesh J. Samani,William E. Kraus,Svati H. Shah,Bing Yu,Eric Boerwinkle,Daniel J. Rader,Namrata Gupta,Philippe M. Frossard,Asif Rasheed,John Danesh,Eric S. Lander,Stacey Gabriel,Danish Saleheen,Kiran Musunuru,Sekar Kathiresan　JOURNAL OF THE AMERICAN COLLEGE OF CARDIOLOGY　69　16　2054　2017/04　
  • 　Impact of genetic testing on low-density lipoprotein cholesterol in patients with familial hypercholesterolemia (GenTLe-FH): a randomised waiting list controlled open-label study protocol.　Nomura A,Tada H,Okada H,Nohara A,Ishikawa H,Yoshimura K,Kawashiri MA　BMJ open　8　12　e023636　2018/12
  • 　Functional analysis of KCNH2 gene mutations of type 2 long QT syndrome in larval zebrafish using microscopy and electrocardiography　Yoshihiro Tanaka,Kenshi Hayashi,Noboru Fujino,Tetsuo Konno,Hayato Tada,Chiaki Nakanishi,Akihiko Hodatsu,Toyonobu Tsuda,Yoji Nagata,Ryota Teramoto,Shohei Yoshida,Akihiro Nomura,Masa-aki Kawashiri,Masakazu Yamagishi　Heart and Vessels　34　1　159　2019/01　
  • 　Analysis of predicted loss-of-function variants in UK Biobank identifies variants protective for disease　Connor A. Emdin,Connor A. Emdin,Connor A. Emdin,Amit V. Khera,Amit V. Khera,Amit V. Khera,Mark Chaffin,Mark Chaffin,Mark Chaffin,Derek Klarin,Derek Klarin,Derek Klarin,Pradeep Natarajan,Pradeep Natarajan,Pradeep Natarajan,Krishna Aragam,Krishna Aragam,Krishna Aragam,Mary Haas,Mary Haas,Mary Haas,Alexander Bick,Alexander Bick,Seyedeh M. Zekavat,Seyedeh M. Zekavat,Seyedeh M. Zekavat,Akihiro Nomura,Akihiro Nomura,Akihiro Nomura,Diego Ardissino,Diego Ardissino,James G. Wilson,Heribert Schunkert,Ruth McPherson,Hugh Watkins,Hugh Watkins,Roberto Elosua,Roberto Elosua,Roberto Elosua,Matthew J. Bown,Nilesh J. Samani,Usman Baber,Jeanette Erdmann,Namrata Gupta,John Danesh,John Danesh,John Danesh,Daniel Chasman,Paul Ridker,Joshua Denny,Lisa Bastarache,Judith H. Lichtman,Gail D'Onofrio,Jennifer Mattera,John A. Spertus,Wayne H.H. Sheu,Kent D. Taylor,Bruce M. Psaty,Bruce M. Psaty,Stephen S. Rich,Wendy Post,Jerome I. Rotter,Yii Der,Ida Chen,Harlan Krumholz,Danish Saleheen,Danish Saleheen,Stacey Gabriel,Sekar Kathiresan,Sekar Kathiresan,Sekar Kathiresan　Nature Communications　9　2018/12/01　
  • 　Late gadolinium enhancement for prediction of mutation-positive hypertrophic cardiomyopathy on the basis of panel-wide sequencing　Ryota Teramoto,Noboru Fujino,Tetsuo Konno,Akihiro Nomura,Yoji Nagata,Toyonobu Tsuda,Hayato Tada,Kenji Sakata,Masakazu Yamagishi,Kenshi Hayashi,Masa-Aki Kawashiri　Circulation Journal　82　4　1139　2018　
  • 　A Novel Smoking Cessation Smartphone App Integrated With a Mobile Carbon Monoxide Checker for Smoking Cessation Treatment: Protocol for a Randomized Controlled Trial.　Akihiro Nomura,Hiroki Tateno,Katsunori Masaki,Tomoyasu Muto,Shin Suzuki,Kohta Satake,Eisuke Hida,Koichi Fukunaga　JMIR research protocols　8　2　e12252　2019/02/11
  • 　Impact of concomitant peripheral artery disease on contrast-induced acute kidney injury and mortality in patients with acute coronary syndrome after percutaneous coronary intervention.　Takuya Nakahashi,Hayato Tada,Kenji Sakata,Yohei Yakuta,Taiji Yoshida,Yoshihiro Tanaka,Akihiro Nomura,Hidenobu Terai,Yuki Horita,Masatoshi Ikeda,Masanobu Namura,Masayuki Takamura,Masa-Aki Kawashiri　Heart and vessels　35　10　1360　2020/10
  • 　Hokuriku-plus familial hypercholesterolaemia registry study: rationale and study design.　Hayato Tada,Hirofumi Okada,Shohei Yoshida,Masaya Shimojima,Akihiro Nomura,Toyonobu Tsuda,Mika Mori,Shin-Ichiro Takashima,Takeshi Kato,Soichiro Usui,Kenji Sakata,Kenshi Hayashi,Noboru Fujino,Akihiro Inazu,Shizuko Takahara,Yasuhito Imai,Takao Matsubara,Atsushi Nohara,Kenji Miwa,Masanobu Namura,Hidenobu Terai,Taiji Yoshida,Tsutomu Araki,Masahiro Minamoto,Toru Aburao,Yuji Ito,Chiaki Nakanishi,Suguru Kawasaki,Yasuhiro Todo,Junji Koizumi,Yoshihito Kita,Hiroshi Matsumoto,Hiroaki Shintaku,Akihiko Hodatsu,Hidekazu Ino,Toshinori Higashikata,Mutsuko Takata,Katsushi Misawa,Masato Yamaguchi,Yoshihiro Noji,Kazuo Osato,Tomohito Mabuchi,Taro Ichise,Bunji Kaku,Shoji Katsuda,Manabu Fujimoto,Katsuharu Uchiyama,Kensuke Fujioka,Takuya Nakahashi,Tsuyoshi Nozue,Ichiro Michishita,Kazuo Usuda,Kanichi Otowa,Kazuyasu Okeie,Satoshi Hirota,Isao Aburadani,Keisuke Kurokawa,Osamu Takatori,Shunichiro Hondo,Hiroyuki Oda,Shigeo Takata,Hisayoshi Murai,Masaki Kinoshita,Hideo Nagai,Yoshiteru Sekiguchi,Satoru Sakagami,Wataru Omi,Chikara Fujita,Tatsuo Katsuki,Hiroshi Ootsuji,Atsushi Igarashi,Manabu Nakano,Seiichiro Okura,Koji Maeno,Yasuhito Mitamura,Naoki Sugimoto,Masakazu Yamamoto,Hironobu Akao,Kouji Kajinami,Masayuki Takamura,Masa-Aki Kawashiri　BMJ open　10　9　e038623　2020/09/10
  • 　A multicenter clinical trial to assess the efficacy of the digital therapeutics for essential hypertension: Rationale and design of the HERB-DH1 trial.　Kazuomi Kario,Akihiro Nomura,Noriko Harada,Tomoyuki Tanigawa,Ryuhei So,Kiyose Nakagawa,Shin Suzuki,Ayako Okura,Eisuke Hida,Kohta Satake　Journal of clinical hypertension (Greenwich, Conn.)　22　9　1713　2020/09
  • 　Transient swallowing-induced atrial tachycardia in a patient with genotyped hypertrophic cardiomyopathy.　Noboru Fujino,Kenshi Hayashi,Kenji Sakata,Hayato Tada,Chiaki Nakanishi,Toyonobu Tsuda,Akihiro Nomura,Shohei Yoshida,Yuichiro Sakamoto,Takeshi Kato,Hiroshi Furusho,Masa-Aki Kawashiri,Masayuki Takamura　Clinical case reports　8　9　1809　2020/09　
  • 　Efficacy of the Ascure Smoking Cessation Program: Retrospective Study.　Ayaka Kato,Tomoyuki Tanigawa,Kohta Satake,Akihiro Nomura　JMIR mHealth and uHealth　8　5　e17270　2020/05/14
  • 　Fasting and Non-Fasting Triglycerides and Risk of Cardiovascular Events in Diabetic Patients Under Statin Therapy.　Hayato Tada,Akihiro Nomura,Kenichi Yoshimura,Hiroshi Itoh,Issei Komuro,Masakazu Yamagishi,Masayuki Takamura,Masa-Aki Kawashiri　Circulation journal : official journal of the Japanese Circulation Society　84　3　509　2020/02/25
  • 　Beneficial effect of ezetimibe-atorvastatin combination therapy in patients with a mutation in ABCG5 or ABCG8 gene.　Hayato Tada,Hirofumi Okada,Akihiro Nomura,Masayuki Takamura,Masa-Aki Kawashiri　Lipids in health and disease　19　1　3　2020/01/04
  • 　A randomized controlled trial of a smoking cessation smartphone application with a carbon monoxide checker.　Katsunori Masaki,Hiroki Tateno,Akihiro Nomura,Tomoyasu Muto,Shin Suzuki,Kohta Satake,Eisuke Hida,Koichi Fukunaga　NPJ digital medicine　3　35　2020
  • 　Rare and Deleterious Mutations in ABCG5/ABCG8 Genes Contribute to Mimicking and Worsening of Familial Hypercholesterolemia Phenotype.　Hayato Tada,Hirofumi Okada,Akihiro Nomura,Satoshi Yashiro,Atsushi Nohara,Yasushi Ishigaki,Masayuki Takamura,Masa-Aki Kawashiri　Circulation journal : official journal of the Japanese Circulation Society　83　9　1917　2019/08/23
  • 　Effect of hypertrophic cardiomyopathy on the prediction of thromboembolism in patients with nonvalvular atrial fibrillation.　Toyonobu Tsuda,Kenshi Hayashi,Noboru Fujino,Tetsuo Konno,Hayato Tada,Akihiro Nomura,Yoshihiro Tanaka,Kenji Sakata,Hiroshi Furusho,Masayuki Takamura,Masa-Aki Kawashiri,Masakazu Yamagishi　Heart rhythm　16　6　829　2019/06
  • 　Quick sepsis-related organ failure assessment score as a possible predictor for in-hospital adverse events in infective endocarditis.　Yudai Tamura,Akihiro Nomura,Shohei Yoshida,Hayato Tada,Kenji Sakata,Kenji Iino,Hiroshi Furusho,Masayuki Takamura,Hirofumi Takemura,Masakazu Yamagishi,Masa-Aki Kawashiri　Acute medicine & surgery　6　2　138　2019/04
  • 　Impact of a Novel Smartphone App (CureApp Smoking Cessation) on Nicotine Dependence: Prospective Single-Arm Interventional Pilot Study.　Katsunori Masaki,Hiroki Tateno,Naofumi Kameyama,Eriko Morino,Riri Watanabe,Kazuma Sekine,Tomohiro Ono,Kohta Satake,Shin Suzuki,Akihiro Nomura,Tomoko Betsuyaku,Koichi Fukunaga　JMIR mHealth and uHealth　7　2　e12694　2019/02/19
  • 　Clinical Efficacy of Telemedicine Compared to Face-to-Face Clinic Visits for Smoking Cessation: Multicenter Open-Label Randomized Controlled Noninferiority Trial.　Akihiro Nomura,Tomoyuki Tanigawa,Tomoyasu Muto,Takafumi Oga,Yasushi Fukushima,Arihiro Kiyosue,Masaki Miyazaki,Eisuke Hida,Kohta Satake　Journal of medical Internet research　21　4　e13520　2019/04/26
  • 　Reply to the Editor— Patients with atrial fibrillation with hypertrophic cardiomyopathy: Do we need new stroke risk stratification?　Toyonobu Tsuda,Akihiro Nomura,Kenshi Hayashi　Heart Rhythm　16　8　e56　2019/08
  • 　SUN-LB110 The Nutrition Education Using a Health Care Application With Artificial Intelligence in Patients With Diabetes Mellitus　Takuya Higashitani,Mitsuhiro Kometani,Rie Oka,Yuko Gondo,Akihiro Nomura,Ayaka Yasugi,Daisuke Aono,Shigehiro Karashima,Takashi Yoneda　Journal of the Endocrine Society　4　Supplement_1　2020/05/08　
  • 　Study Protocol for the Effects of Artificial Intelligence (AI)-Supported Automated Nutritional Intervention on Glycemic Control in Patients with Type 2 Diabetes Mellitus　Rie Oka,Akihiro Nomura,Ayaka Yasugi,Mitsuhiro Kometani,Yuko Gondoh,Kenichi Yoshimura,Takashi Yoneda　Diabetes Therapy　10　3　1151　2019/06/01　
  • 　MON-LB304 The Construction of the Online Health Guidance Service for Life-Style Related Diseases (Kanazawa Slim Study)　Mitsuhiro Kometani,Rie Oka,Ayaka Yasugi,Yuko Gondo,Akihiro Nomura,Daisuke Aono,Takuya Higashitani,Shigehiro Karashima,Mikiya Usukura,Kenji D Furukawa,Takashi Yoneda　Journal of the Endocrine Society　4　Supplement_1　2020/05/08　
  • 　Impact of decreased ankle-brachial index on 30-day bleeding complications and long-term mortality in patients with acute coronary syndrome after percutaneous coronary intervention.　Takuya Nakahashi,Hayato Tada,Kenji Sakata,Yohei Yakuta,Yoshihiro Tanaka,Tadatsugu Gamou,Akihiro Nomura,Hidenobu Terai,Yuki Horita,Masatoshi Ikeda,Masanobu Namura,Masayuki Takamura,Kenshi Hayashi,Masakazu Yamagishi,Masa-Aki Kawashiri　Journal of cardiology　74　2　116　2019/08
  • 　Feasibility of a Novel Mobile C-Reactive Protein-Testing Device Using Gold-Linked Electrochemical Immunoassay: Clinical Performance Study.　Yuko Gondoh-Noda,Mitsuhiro Kometani,Akihiro Nomura,Daisuke Aono,Shigehiro Karashima,Hiromi Ushijima,Eiichi Tamiya,Toshinori Murayama,Takashi Yoneda　JMIR mHealth and uHealth　8　9　e18782　2020/09/07
  • 　Protocol For An Adjuvant Alpha-Fetoprotein-Derived Peptide After Transarterial Chemoembolization in Patients With Hepatocellular Carcinoma: Safety Study.　Akihiro Nomura,Takeshi Terashima,Eishiro Mizukoshi,Masaaki Kitahara,Toshinori Murayama,Shuichi Kaneko　JMIR research protocols　9　2　e17082　2020/02/10
  • 　Comparing Telemedicine and Face-to-Face Consultation Based on the Standard Smoking Cessation Program for Nicotine Dependence: Protocol for a Randomized Controlled Trial.　Tomoyuki Tanigawa,Akihiro Nomura,Maki Kuroda,Tomoyasu Muto,Eisuke Hida,Kohta Satake　JMIR research protocols　8　7　e12701　2019/07/09
  • 　A catalogue of the pathogenic mutations of LDL receptor gene in Japanese familial hypercholesterolemia　Tada H,Hori M,Nomura A,Hosomichi K,Nohara A,Kawashiri MA,Harada-Shiba M　Journal of Clinical Lipidology　2020/03
  • 　Impact of functional studies on exome sequence variant interpretation in early-onset cardiac conduction system diseases.　Kenshi Hayashi,Ryota Teramoto,Akihiro Nomura,Yoshihiro Asano,Manu Beerens,Yasutaka Kurata,Isao Kobayashi,Noboru Fujino,Hiroshi Furusho,Kenji Sakata,Kenji Onoue,David Y Chiang,Tuomas O Kiviniemi,Eva Buys,Patrick Sips,Micah L Burch,Yanbin Zhao,Amy E Kelly,Masanobu Namura,Yoshihito Kita,Taketsugu Tsuchiya,Bunji Kaku,Kotaro Oe,Yuko Takeda,Tetsuo Konno,Masaru Inoue,Takashi Fujita,Takeshi Kato,Akira Funada,Hayato Tada,Akihiko Hodatsu,Chiaki Nakanishi,Yuichiro Sakamoto,Toyonobu Tsuda,Yoji Nagata,Yoshihiro Tanaka,Hirofumi Okada,Keiich Usuda,Shihe Cui,Yoshihiko Saito,Calum A MacRae,Seiji Takashima,Masakazu Yamagishi,Masa-Aki Kawashiri,Masayuki Takamura　Cardiovascular research　116　13　2116　2020/01/24
  • 　Rare Protein-Truncating Variants in APOB, Lower Low-Density Lipoprotein Cholesterol, and Protection Against Coronary Heart Disease.　Peloso GM,Nomura A,Khera AV,Chaffin M,Won HH,Ardissino D,Danesh J,Schunkert H,Wilson JG,Samani N,Erdmann J,McPherson R,Watkins H,Saleheen D,McCarthy S,Teslovich TM,Leader JB,Lester Kirchner H,Marrugat J,Nohara A,Kawashiri MA,Tada H,Dewey FE,Carey DJ,Baras A,Kathiresan S　Circulation. Genomic and precision medicine　12　5　e002376　2019/05
  • 　Artificial Intelligence in Current Diabetes Management and Prediction.　Akihiro Nomura,Masahiro Noguchi,Mitsuhiro Kometani,Kenji Furukawa,Takashi Yoneda　Current diabetes reports　21　12　61　2021/12/13
  • 　Personalized medicine for cardiovascular diseases.　Hayato Tada,Noboru Fujino,Akihiro Nomura,Chiaki Nakanishi,Kenshi Hayashi,Masayuki Takamura,Masa-Aki Kawashiri　Journal of human genetics　66　1　67　2021/01　
  • 　Sitosterolemia Exhibiting Severe Hypercholesterolemia with Tendon Xanthomas Due to Compound Heterozygous ABCG5 Gene Mutations Treated with Ezetimibe and Alirocumab.　Hiroki Tanaka,Yuki Watanabe,Shuji Hirano,Hayato Tada,Akihiro Nomura,Masa-Aki Kawashiri,Makoto Takenaga　Internal medicine (Tokyo, Japan)　59　23　3033　2020/12/01
  • 　The Association Between Serum Uric Acid and Mortality in Patients with Acute Coronary Syndrome After Percutaneous Coronary Intervention.　Takuya Nakahashi,Hayato Tada,Kenji Sakata,Taiji Yoshida,Yoshihiro Tanaka,Akihiro Nomura,Hidenobu Terai,Yuki Horita,Masatoshi Ikeda,Masanobu Namura,Masayuki Takamura,Masa-Aki Kawashiri　International heart journal　63　3　447　2022/05/31
  • 　Clinical Diagnostic Criteria of Familial Hypercholesterolemia - A Comparison of the Japan Atherosclerosis Society and Dutch Lipid Clinic Network Criteria.　Hayato Tada,Hirofumi Okada,Akihiro Nomura,Soichiro Usui,Kenji Sakata,Atsushi Nohara,Masakazu Yamagishi,Masayuki Takamura,Masa-Aki Kawashiri　Circulation journal : official journal of the Japanese Circulation Society　85　6　891　2020/12/03
  • 　Prevalence and Impact of Apolipoprotein E7 on LDL Cholesterol Among Patients With Familial Hypercholesterolemia.　Hayato Tada,Kan Yamagami,Nobuko Kojima,Junichi Shibayama,Tetsuo Nishikawa,Hirofumi Okada,Akihiro Nomura,Soichiro Usui,Kenji Sakata,Masayuki Takamura,Masa-Aki Kawashiri　Frontiers in cardiovascular medicine　8　625852　2021
  • 　JCS 2018 Guideline on Diagnosis of Chronic Coronary Heart Diseases.　Masakazu Yamagishi,Nagara Tamaki,Takashi Akasaka,Takanori Ikeda,Kenji Ueshima,Shiro Uemura,Yutaka Otsuji,Yasuki Kihara,Kazuo Kimura,Takeshi Kimura,Yoshiki Kusama,Shinichiro Kumita,Hajime Sakuma,Masahiro Jinzaki,Hiroyuki Daida,Yasuchika Takeishi,Hiroshi Tada,Taishiro Chikamori,Kenichi Tsujita,Kunihiko Teraoka,Kenichi Nakajima,Tomoaki Nakata,Satoshi Nakatani,Akihiko Nogami,Koichi Node,Atsushi Nohara,Atsushi Hirayama,Nobusada Funabashi,Masaru Miura,Teruhito Mochizuki,Hiroyoshi Yokoi,Kunihiro Yoshioka,Masafumi Watanabe,Toshihiko Asanuma,Yuichi Ishikawa,Takahiro Ohara,Koichi Kaikita,Tokuo Kasai,Eri Kato,Hiroshi Kamiyama,Masaaki Kawashiri,Keisuke Kiso,Kakuya Kitagawa,Teruhito Kido,Toshio Kinoshita,Tomonari Kiriyama,Teruyoshi Kume,Akira Kurata,Satoshi Kurisu,Masami Kosuge,Eitaro Kodani,Akira Sato,Yasutsugu Shiono,Hiroki Shiomi,Junichi Taki,Masaaki Takeuchi,Atsushi Tanaka,Nobuhiro Tanaka,Ryoichi Tanaka,Takuya Nakahashi,Takehiro Nakahara,Akihiro Nomura,Akiyoshi Hashimoto,Kenshi Hayashi,Masahiro Higashi,Takafumi Hiro,Daisuke Fukamachi,Hitoshi Matsuo,Naoya Matsumoto,Katsumi Miyauchi,Masao Miyagawa,Yoshitake Yamada,Keiichiro Yoshinaga,Hideki Wada,Tetsu Watanabe,Yukio Ozaki,Shun Kohsaka,Wataru Shimizu,Satoshi Yasuda,Hideaki Yoshino　Circulation journal : official journal of the Japanese Circulation Society　85　4　402　2021/03/25
  • 　Diagnosis and Management of Sitosterolemia 2021.　Hayato Tada,Akihiro Nomura,Masatsune Ogura,Katsunori Ikewaki,Yasushi Ishigaki,Kyoko Inagaki,Kazuhisa Tsukamoto,Kazushige Dobashi,Kimitoshi Nakamura,Mika Hori,Kota Matsuki,Shizuya Yamashita,Shinji Yokoyama,Masa-Aki Kawashiri,Mariko Harada-Shiba　Journal of atherosclerosis and thrombosis　28　8　791　2021/04/28
  • 　Digital therapeutics for essential hypertension using a smartphone application: A randomized, open-label, multicenter pilot study.　Kazuomi Kario,Akihiro Nomura,Ayaka Kato,Noriko Harada,Tomoyuki Tanigawa,Ryuhei So,Shin Suzuki,Eisuke Hida,Kohta Satake　Journal of clinical hypertension (Greenwich, Conn.)　23　5　923　2021/05
  • 　Polygenic risk scores for low-density lipoprotein cholesterol and familial hypercholesterolemia.　Akihiro Nomura,Takehiro Sato,Hayato Tada,Takayuki Kannon,Kazuyoshi Hosomichi,Hiromasa Tsujiguchi,Hiroyuki Nakamura,Masayuki Takamura,Atsushi Tajima,Masa-Aki Kawashiri　Journal of human genetics　66　11　1079　2021/05/10
  • 　Inflammatory and Hypercoagulable Biomarkers and Clinical Outcomes in COVID-19 Patients.　Hiroki Kitakata,Shun Kohsaka,Shunsuke Kuroda,Akihiro Nomura,Takeshi Kitai,Taishi Yonetsu,Sho Torii,Yuya Matsue,Shingo Matsumoto　Journal of clinical medicine　10　14　2021/07/13
  • 　Efficacy of a digital therapeutics system in the management of essential hypertension: the HERB-DH1 pivotal trial.　Kazuomi Kario,Akihiro Nomura,Noriko Harada,Ayako Okura,Kiyose Nakagawa,Tomoyuki Tanigawa,Eisuke Hida　European heart journal　42　40　4111　2021/08/29
  • 　Effects of Different Types of Pathogenic Variants on Phenotypes of Familial Hypercholesterolemia.　Hayato Tada,Nobuko Kojima,Kan Yamagami,Akihiro Nomura,Atsushi Nohara,Soichiro Usui,Kenji Sakata,Noboru Fujino,Masayuki Takamura,Masa-Aki Kawashiri　Frontiers in genetics　13　872056　2022
  • 　Children with Severe Hypercholesterolemia Caused by a Pathogenic Mutation in ABCG5.　Hayato Tada,Hirofumi Okada,Akihiro Nomura,Masayuki Takamura,Masa-Aki Kawashiri　Internal medicine (Tokyo, Japan)　62　2　251　2022/06/14
  • 　Effects of artificial intelligence-SsupporTed Automated NutRiTional Intervention on LDL cholesterol Control in Patients with Familial Hypercholesterolaemia (iSTART-FH): protocol for a randomised controlled trial　Hayato Tada,Hirofumi Okada,Akihiro Nomura,Soichiro Usui,Kenji Sakata,Kenshi Hayashi,Noboru Fujino,Ayaka Yasugi,Shizuko Takahara,Yasuhito Imai,Masayuki Takamura,Masa-aki Kawashiri　BMJ Open　2021/12
  • 　Prevalence, self-awareness, and LDL cholesterol levels among patients highly suspected as familial hypercholesterolemia in a Japanese community.　Hayato Tada,Junichi Shibayama,Tetsuo Nishikawa,Hirofumi Okada,Akihiro Nomura,Soichiro Usui,Kenji Sakata,Atsushi Hashiba,Akihiro Inazu,Masayuki Takamura,Masa-Aki Kawashiri　Practical laboratory medicine　22　e00181　2020/11
  • 　Explainable Machine Learning for Atrial Fibrillation in the General Population Using a Generalized Additive Model - A Cross-Sectional Study.　Masaki Kawakami,Shigehiro Karashima,Kento Morita,Hayato Tada,Hirofumi Okada,Daisuke Aono,Mitsuhiro Kometani,Akihiro Nomura,Masashi Demura,Kenji Furukawa,Takashi Yoneda,Hidetaka Nambo,Masa-Aki Kawashiri　Circulation reports　4　2　73　2022/02/10
  • 　Randomized placebo-controlled double-blind phase II study of zaltoprofen for patients with diffuse-type and unresectable localized tenosynovial giant cell tumors: The REALIZE study.　Akihiko Takeuchi,Makoto Endo,Akira Kawai,Yoshihiro Nishida,Ryu Terauchi,Akihiko Matsumine,Hisaki Aiba,Tomoki Nakamura,Susumu Tandai,Toshifumi Ozaki,Manabu Hoshi,Daiki Kayano,Miho Okuda,Norio Yamamoto,Katsuhiro Hayashi,Shinji Miwa,Kentaro Igarashi,Kenichi Yoshimura,Akihiro Nomura,Toshinori Murayama,Hiroyuki Tsuchiya　Frontiers in oncology　12　900010　2022
  • 　Early Detection of Symptom Exacerbation in Patients With SARS-CoV-2 Infection Using the Fitbit Charge 3 (DEXTERITY): Pilot Evaluation.　Kan Yamagami,Akihiro Nomura,Mitsuhiro Kometani,Masaya Shimojima,Kenji Sakata,Soichiro Usui,Kenji Furukawa,Masayuki Takamura,Masaki Okajima,Kazuyoshi Watanabe,Takashi Yoneda　JMIR formative research　5　9　e30819　2021/09/16
  • 　Prognostic impact of cascade screening for familial hypercholesterolemia on cardiovascular events.　Hayato Tada,Hirofumi Okada,Akihiro Nomura,Atsushi Nohara,Masakazu Yamagishi,Masayuki Takamura,Masa-Aki Kawashiri　Journal of clinical lipidology　2021/01/04
  • 　Heterozygous ABCG5 Gene Deficiency and Risk of Coronary Artery Disease.　Akihiro Nomura,Connor A Emdin,Hong Hee Won,Gina M Peloso,Pradeep Natarajan,Diego Ardissino,John Danesh,Heribert Schunkert,Adolfo Correa,Matthew J Bown,Nilesh J Samani,Jeanette Erdmann,Ruth McPherson,Hugh Watkins,Danish Saleheen,Roberto Elosua,Masa-Aki Kawashiri,Hayato Tada,Namrata Gupta,Svati H Shah,Daniel J Rader,Stacey Gabriel,Amit V Khera,Sekar Kathiresan　Circulation. Genomic and precision medicine　13　5　417　2020/10
  • 　Whole Exome Sequencing Insufficient for a Definitive Diagnosis of a Patient with Compound Heterozygous Familial Hypercholesterolemia.　Hirofumi Okada,Hayato Tada,Akihiro Nomura,Atsushi Nohara,Kazuyasu Okeie,Tsuyoshi Nozue,Ichiro Michishita,Masayuki Takamura,Hirofumi Takemura,Masa-Aki Kawashiri　Internal medicine (Tokyo, Japan)　61　19　2883　2022
  • 　Efficacy and safety of early initiation of eplerenone treatment in patients with acute heart failure (EARLIER trial): a multicenter, randomized, double-blind, placebo-controlled trial.　Masanori Asakura,Shin Ito,Takahisa Yamada,Yoshihiko Saito,Kazuo Kimura,Akira Yamashina,Atsushi Hirayama,Youichi Kobayashi,Akihisa Hanatani,Mitsuru Tsujimoto,Satoshi Yasuda,Yukio Abe,Yorihiko Higashino,Youdo Tamaki,Hiroshi Sugino,Hiroyuki Niinuma,Yoshitaka Okuhara,Toshimi Koitabashi,Shin-Ichi Momomura,Kuniya Asai,Akihiro Nomura,Hiroya Kawai,Yasuhiro Satoh,Tsutomu Yoshikawa,Ken-Ichi Hirata,Yoshiaki Yokoi,Jun Tanaka,Yoshisato Shibata,Yasuhiro Maejima,Shunsuke Tamaki,Hiroyuki Kawta,Noriaki Iwahashi,Masatake Kobayashi,Yoshiharu Higuchi,Akiko Kada,Haruko Yamamoto,Masafumi Kitakaze　European heart journal. Cardiovascular pharmacotherapy　8　2　108　2020/11/11
  • 　A reassessment of the Japanese clinical diagnostic criteria of familial hypercholesterolemia in a hospital-based cohort using comprehensive genetic analysis.　Hayato Tada,Hirofumi Okada,Akihiro Nomura,Atsushi Nohara,Soichiro Usui,Kenji Sakata,Masayuki Takamura,Masa-Aki Kawashiri　Practical laboratory medicine　22　e00180　2020/11
  • 　Cost-effectiveness of digital therapeutics for essential hypertension.　Akihiro Nomura,Tomoyuki Tanigawa,Kazuomi Kario,Ataru Igarashi　Hypertension research : official journal of the Japanese Society of Hypertension　45　10　1538　2022/10
  • 　The Usefulness of a Smartphone App-Based Smoking Cessation Program for Conventional Cigarette Users, Heated Tobacco Product Users, and Dual Users: Retrospective Study.　Yuko Noda,Ryuhei So,Misaki Sonoda,Takahiro Tabuchi,Akihiro Nomura　Journal of medical Internet research　25　e42776　2023/03/17
  • 　Impact of Healthy Lifestyle in Patients With Familial Hypercholesterolemia.　Hayato Tada,Nobuko Kojima,Kan Yamagami,Akihiro Nomura,Atsushi Nohara,Soichiro Usui,Kenji Sakata,Kenshi Hayashi,Noboru Fujino,Masayuki Takamura,Masa-Aki Kawashiri　JACC. Asia　3　1　152　2023/02
  • 　Attainment of the low-density lipoprotein cholesterol treatment target and prognosis of heterozygous familial hypercholesterolemia.　Hayato Tada,Akihiro Nomura,Atsushi Nohara,Soichiro Usui,Kenji Sakata,Kenshi Hayashi,Noboru Fujino,Masayuki Takamura,Masa-Aki Kawashiri　Atherosclerosis　371　61　2023/04
  • 　Characterization of baseline clinical factors associated with incident worsening kidney function in patients with non-valvular atrial fibrillation: the Hokuriku-Plus AF Registry.　Kenshi Hayashi,Yoshihiro Tanaka,Toyonobu Tsuda,Akihiro Nomura,Noboru Fujino,Hiroshi Furusho,Norihiko Sakai,Yasunori Iwata,Soichiro Usui,Kenji Sakata,Takeshi Kato,Hayato Tada,Takashi Kusayama,Keisuke Usuda,Masa-Aki Kawashiri,Rod S Passman,Takashi Wada,Masakazu Yamagishi,Masayuki Takamura　Heart and vessels　38　3　402　2022/10/17
  • 　Impact of Providing Future Cardiovascular Risk Based on Genetic Testing on Low-Density Lipoprotein Cholesterol in Patients with Familial Hypercholesterolemia (GenTLe-FH): A Randomized Wait-list Controlled Open-Label Trial　Akihiro Nomura,Hirofumi Okada,Atsushi Nohara,Masaaki Kawashiri,Masayuki Takamura,Hayato Tada　2023/03/27
  • 　Outcomes of a telemedicine smoking cessation programme for heated tobacco product users in Japan: a retrospective cohort study.　Akihiro Nomura,Takaaki Ikeda,Toshiki Fujimoto,Yusaku Morita,Chie Taniguchi,Tetsuro Ishizawa,Takahiro Tabuchi　BMJ open　12　12　e063489　2022/12/20
  • 　Clinical Characteristics, Outcomes, and Risk Factors for Adverse Events in Elderly and Non-Elderly Japanese Patients With Non-Valvular Atrial Fibrillation - Competing Risk Analysis From the Hokuriku-Plus AF Registry.　Toyonobu Tsuda,Kenshi Hayashi,Takeshi Kato,Keisuke Usuda,Takashi Kusayama,Akihiro Nomura,Hayato Tada,Soichiro Usui,Kenji Sakata,Masa-Aki Kawashiri,Noboru Fujino,Masakazu Yamagishi,Masayuki Takamura　Circulation reports　4　7　298　2022/07/08
  • 　Impact of variants of uncertain significance of LDL receptor on phenotypes of familial hypercholesterolemia.　Hayato Tada,Nobuko Kojima,Kan Yamagami,Akihiro Nomura,Atsushi Nohara,Soichiro Usui,Kenji Sakata,Kenshi Hayashi,Noboru Fujino,Masayuki Takamura,Masa-Aki Kawashiri　Journal of clinical lipidology　54回　6　203　2022/09/30
  • 　Coronary artery calcium among patients with heterozygous familial hypercholesterolaemia.　Hayato Tada,Nobuko Kojima,Kan Yamagami,Akihiro Nomura,Atsushi Nohara,Soichiro Usui,Kenji Sakata,Kenshi Hayashi,Noboru Fujino,Masayuki Takamura,Masa-Aki Kawashiri　European heart journal open　3　3　oead046　2023/05
  • 　Digital health, digital medicine, and digital therapeutics in cardiology: current evidence and future perspective in Japan.　Akihiro Nomura　Hypertension research : official journal of the Japanese Society of Hypertension　46　9　1　2023/05/31
  • 　Early diagnosis and treatments in childhood are associated with better prognosis in patients with familial hypercholesterolemia.　Hayato Tada,Nobuko Kojima,Kan Yamagami,Akihiro Nomura,Atsushi Nohara,Soichiro Usui,Kenji Sakata,Masayuki Takamura,Masa-Aki Kawashiri　American journal of preventive cardiology　12　100434　2022/12
  • 　Correction: Characterization of baseline clinical factors associated with incident worsening kidney function in patients with non-valvular atrial fibrillation: the Hokuriku-Plus AF Registry.　Kenshi Hayashi,Yoshihiro Tanaka,Toyonobu Tsuda,Akihiro Nomura,Noboru Fujino,Hiroshi Furusho,Norihiko Sakai,Yasunori Iwata,Soichiro Usui,Kenji Sakata,Takeshi Kato,Hayato Tada,Takashi Kusayama,Keisuke Usuda,Masa-Aki Kawashiri,Rod S Passman,Takashi Wada,Masakazu Yamagishi,Masayuki Takamura　Heart and vessels　38　3　412　2023/03
  • 　Human leukocyte antigen-DQ risk heterodimeric haplotypes of left ventricular dysfunction in cardiac sarcoidosis: an autoimmune view of its role.　Hironori Yamamoto,Yohei Miyashita,Hitoshi Minamiguchi,Kazuyoshi Hosomichi,Shohei Yoshida,Hidetaka Kioka,Haruki Shinomiya,Haruno Nagata,Kenji Onoue,Masato Kawasaki,Yuki Kuramoto,Akihiro Nomura,Yuichiro Toma,Tetsuya Watanabe,Takahisa Yamada,Yasuki Ishihara,Miho Nagata,Hisakazu Kato,Hideyuki Hakui,Yoshihiko Saito,Yoshihiro Asano,Yasushi Sakata　Scientific reports　13　1　19767　2023/11/13
  • 　The utility of zebrafish cardiac arrhythmia model to predict the pathogenicity of KCNQ1 variants.　Shihe Cui,Kenshi Hayashi,Isao Kobayashi,Kazuyoshi Hosomichi,Akihiro Nomura,Ryota Teramoto,Keisuke Usuda,Hirofumi Okada,Yaowen Deng,Jingjing Kobayashi-Sun,Tetsuo Nishikawa,Hiroshi Furusho,Takekatsu Saito,Hiroaki Hirase,Kunio Ohta,Manabu Fujimoto,Yuki Horita,Takashi Kusayama,Toyonobu Tsuda,Hayato Tada,Takeshi Kato,Soichiro Usui,Kenji Sakata,Noboru Fujino,Atsushi Tajima,Masakazu Yamagishi,Masayuki Takamura　Journal of molecular and cellular cardiology　177　50　2023/03/08
  • 　Putative Pathogenic Variants of ABCG5 and ABCG8 of Sitosterolemia in Patients With Hyper-Low-Density Lipoprotein Cholesterolemia　Nobuko Kojima,Hayato Tada,Akihiro Nomura,Soichiro Usui,Kenji Sakata,Kenshi Hayashi,Atsushi Nohara,Akihiro Inazu,Masa-aki Kawashiri,Masayuki Takamura　Journal of Lipid and Atherosclerosis　2024
  • 　Performance of Generative Pretrained Transformer on the National Medical Licensing Examination in Japan.　Yudai Tanaka,Takuto Nakata,Ko Aiga,Takahide Etani,Ryota Muramatsu,Shun Katagiri,Hiroyuki Kawai,Fumiya Higashino,Masahiro Enomoto,Masao Noda,Mitsuhiro Kometani,Masayuki Takamura,Takashi Yoneda,Hiroaki Kakizaki,Akihiro Nomura　PLOS digital health　3　1　e0000433　2024/01
  • 　Impact of providing genetics-based future cardiovascular risk on LDL-C in patients with familial hypercholesterolemia.　Akihiro Nomura,Hirofumi Okada,Atsushi Nohara,Masa-Aki Kawashiri,Masayuki Takamura,Hayato Tada　Journal of clinical lipidology　2023/08/26
  • 　Smartphone-Assisted Medical Care for Vestibular Dysfunction as a Telehealth Strategy for Digital Therapy Beyond COVID-19: Scoping Review.　Masao Noda,Tatsuaki Kuroda,Akihiro Nomura,Makoto Ito,Tomokazu Yoshizaki,Hiroaki Fushiki　JMIR mHealth and uHealth　11　e48638　2023/09/11
  • 　Efficacy of azilsartan on left ventricular diastolic dysfunction compared with candesartan: J-TASTE randomized controlled trial.　Shin Ito,Hiroyuki Takahama,Masanori Asakura,Yukio Abe,Masayoshi Ajioka,Toshihisa Anzai,Takuo Arikawa,Takaharu Hayashi,Yorihiko Higashino,Shinya Hiramitsu,Noriaki Iwahashi,Chisato Izumi,Kazuo Kimura,Koichiro Kinugawa,Hidetaka Kioka,Young-Jae Lim,Ken Matsuoka,Satoshi Matsuoka,Hirohiko Motoki,Sunao Nakamura,Takafumi Nakayama,Akihiro Nomura,Taishi Sasaoka,Shin Takiuchi,Shigeru Toyoda,Tomoya Ueda,Tetsuya Watanabe,Akira Yamada,Masayoshi Yamamoto,Takashi Sozu,Masafumi Kitakaze　Scientific reports　13　1　12517　2023/08/02
  • 　Genetic Characteristics Contributing to Lipoprotein(a) Levels in the Japanese Population　Kan Yamagami,Hayato Tada,Takehiro Sato,Akihiro Nomura,Kenji Sakata,Soichiro Usui,Masa-aki Kawashiri,Atsushi Tajima,Masayuki Takamura　Journal of Coronary Artery Disease　29　4　104　2023　
  • 　Performance of GPT-4V in Answering the Japanese Otolaryngology Board Certification Examination Questions: Evaluation Study　Masao Noda,Takayoshi Ueno,Ryota Koshu,Yuji Takaso,Mari Dias Shimada,Chizu Saito,Hisashi Sugimoto,Hiroaki Fushiki,Makoto Ito,Akihiro Nomura,Tomokazu Yoshizaki　JMIR Medical Education　2024/03/28
  • 　Diabetes impairs the angiogenic capacity of human adipose-derived stem cells by reducing the CD271+ subpopulation in adipose tissue　Oto Inoue,Soichiro Usui,Shin ichiro Takashima,A. Nomura,K. Yamaguchi,Yusuke Takeda,Chiaki Goten,Takuto Hamaoka,Hiroshi Ootsuji,Hisayoshi Murai,Shuichi Kaneko,Masayuki Takamura　Biochemical and Biophysical Research Communications　517　2　369　2019/09/17
  • 　Clinical whole exome sequencing in severe hypertriglyceridemia　Hayato Tada,Akihiro Nomura,Hirofumi Okada,Takuya Nakahashi,Tsuyoshi Nozue,Kenshi Hayashi,Atsushi Nohara,Kunimasa Yagi,Akihiro Inazu,Ichiro Michishita,Hiroshi Mabuchi,Masakazu Yamagishi,Masa-aki Kawashiri　Clinica Chimica Acta　488　31　2019/01
  • 　Clinical Efficacy of Telemedicine Compared to Face-to-Face Clinic Visits for Smoking Cessation: Multicenter Open-Label Randomized Controlled Noninferiority Trial.　Akihiro Nomura,Tomoyuki Tanigawa,Tomoyasu Muto,Takafumi Oga,Yasushi Fukushima,Arihiro Kiyosue,Masaki Miyazaki,Eisuke Hida,Kohta Satake　Journal of medical Internet research　21　4　e13520　2019/04/26
  • 　Oligogenic familial hypercholesterolemia, LDL cholesterol, and coronary artery disease.　Tada H,Kawashiri MA,Nomura A,Teramoto R,Hosomichi K,Nohara A,Inazu A,Mabuchi H,Tajima A,Yamagishi M　Journal of clinical lipidology　12　6　1436　2018/11

Conference Presentations

  • 系統臓器別 検査早わかりファイル 第20回 内分泌系 内分泌負荷試験(conference：ナース専科)(2010/05/01)
  • 巨大卵巣嚢腫と鑑別が困難であった神経因性膀胱を契機に発見された緩徐進行型1型糖尿病の1例(conference：日本内分泌学会雑誌)(2010/03/20)
  • シロリムス溶出性ステント留置後5年以上の経過で超遅発性ステント血栓症を来たした2例(conference：日本循環器学会北陸地方会(Web))(2013)
  • A case of pheochromocytoma leading to hypertensive urgency with an initial response using an online clinic Online treatment for highly specialized diseases(conference：JTTA Spring Conference抄録集)(2021)
  • 【臨床シナリオに基づく外来診療スキルアップ〜こんな外来患者さん、先生ならどうしますか?】冠動脈疾患 20年前に冠動脈攣縮が誘発されCa拮抗薬内服を継続するも、その後まったく胸痛の出現がないため服薬中止を希望する患者(conference：Heart View)(2018/11)

show all

  • 遺伝性心疾患の遺伝子診断を日常診療にどう生かすか 肥大型心筋症(conference：日本心臓病学会学術集会抄録)(2015/09)
  • Digital therapy awaken and making a further leap forward(conference：JTTA Spring Conference抄録集)(2021)
  • Clinical efficacy of telemedicine compared to face-to-face clinic visitsfor smoking cessation(conference：日本遠隔医療学会雑誌)(2020/03)
  • 当院における感染性心内膜炎患者の予後と合併症についての検討(conference：感染症学雑誌)(2009/07/20)
  • 当院における感染性心内膜炎患者の疫学と危険因子の検討(conference：感染症学雑誌)(2009/07/20)
  • 肥大型心筋症の心筋線維化検出におけるFragmented QRSの有用性(conference：日本心臓病学会誌)(2013/09/09)
  • 「禁煙アプリ」を併用した標準禁煙治療プログラムにおけるオンライン診療および対面診療の多施設無作為化比較試験プロトコル(conference：日本遠隔医療学会学術大会プログラム・抄録集)(2018/11)
  • 【脂質代謝と心臓血管病:up-to-date】HDLコレステロールと心臓血管病(conference：The Lipid)(2018/10)
  • 高コレステロール血症および網膜症を有する糖尿病患者において血清中トリグリセリドは初回心血管イベントを予測する 無作為化対照試験の事後解析(Serum Triglyceride Predicts First Cardiovascular Events in Diabetic Patients with Hypercholesterolemia and Retinopathy: Post-hoc Analysis of a Randomized Controlled Trial)(conference：日本循環器学会学術集会抄録集)(2018/03)
  • 心臓突然死の遺伝的背景 早発性心臓伝導障害患者のエクソームシーケンシング(Exome Sequencing for Patients with Early-onset Cardiac Conduction Diseases)(conference：日本循環器学会学術集会抄録集)(2017/03)
  • Artificial Intelligence application cured the frailty elderly(conference：JTTA Spring Conference抄録集)(2021)
  • デジタル療法 ニコチン依存症治療用アプリのオンライン診療への応用について(conference：日本遠隔医療学会学術大会プログラム・抄録集)(2019/10)
  • QT延長症候群を有する小児および青年における競技スポーツ中および日常活動中の心イベント(Cardiac Events during Competitive Sports and Daily Activities in Children and Adolescents with Long QT Syndrome)(conference：日本循環器学会学術集会抄録集)(2019/03)
  • 遺伝学から考える動脈硬化性疾患予防・治療、FH & Beyond(conference：日本動脈硬化学会総会プログラム・抄録集)(2019/07)
  • Fragmented QRS as a prognostic tool for predicting cardiac events in hypertrophic cardiomyopathy(conference：EUROPEAN HEART JOURNAL)(2014/09)
  • Cost-Effectiveness Analysis of Digital Therapy for the Patients with Nicotine Dependence(conference：日本遠隔医療学会雑誌)(2019/06)
  • 【遠隔医療の現況と展望】Key words 治療アプリ(conference：カレントテラピー)(2018/12)
  • A randomized controlled trial of a novel smartphone application therapy for smoking cessation(conference：日本呼吸器学会誌(Web))(2020)
  • ここが知りたい循環器診療―パールとピットフォール よくみる症候からのアプローチ―問診,診察のコツと検査の進め方 胸痛を訴える患者の診かた(conference：Medicina)(2014/09/10)
  • 家族性低ベータリポ蛋白血症30家系に対する全エクソームシークエンシング解析(conference：The Lipid)(2017/04)
  • 甲状腺乳頭癌肺転移に対する縦隔放射線治療後に生じた放射線誘発性心疾患の1例(conference：日本循環器学会九州地方会(Web))(2012)
  • 家族性高コレステロール血症診断並びに表現型に対するABCG5・ABCG8遺伝子希少有害変異の寄与に関する検討(conference：日本心臓病学会学術集会抄録)(2019/09)

Others

Arts and Fieldwork

Patent

Theme to the desired joint research

○1. Development of medical devices related to digital health, digital medicine, and digital therapeutics 2. Clinical research towards the evaluation of their clinical performance and social implementation

Grant-in-Aid for Scientific Research

○「多遺伝子リスクスコアを用いた肥大型心筋症における新たな疾患発症機序の解明」(2020-2022)　
○「多遺伝子リスクスコアを用いた肥大型心筋症における新たな疾患発症機序の解明」(2020-2022)　
○「ライフコースに応じた新型タバコの流行とその影響に関する実証研」(2021-2025)　
○「オンライン特定保健指導・オンライン診療におけるPHR活⽤による⾏動変容に関する研究」(2020-2022)　
○「分子疫学的コホート研究による遺伝性心血管疾患のリスク層別化・病態解明・治療薬探索」(2020-2023)　
○「地域住民コホートゲノム情報及び生活習慣情報を用いた動脈硬化性疾患個別化医療の開発」(2021-2023)　
○「遺伝性不整脈症候群の病原性遺伝子変異の決定とそれに基づく個別化医療の実現」(2021-2023)　
○「地域住民コホート研究を用いた先進的ゲノム解析による心不全超精密個別化医療開発」(2022-2024)　
○「網羅的遺伝子解析によるリポ蛋白(a)代謝新規関連分子の探索とその機能解析」(2019-2021)　
○「ヒト心筋生検検体を用いたRNA-Seqによる心臓サルコイドーシスの病態解明」(2019-2021)　
○「遺伝性不整脈の新規原因遺伝子の同定と不整脈発症機序の解明および有効治療薬の決定」(2018-2020)　
○「家族性高コレステロール血症網羅的遺伝子解析スキームの樹立」(2018-2020)　
○「スマートバンドを用いた肥大型心筋症患者における運動強度の評価と心予後との関連解析」(2024-2026)　
○「次世代シークエンサーを用いた家族性肥大型心筋症の新たな病態発症メカニズムの解明」(2017-2018)　
○「次世代シークエンサーを用いた家族性肥大型心筋症の新たな病態発症メカニズムの解 明」(2017-2018)　
○「心筋生検検体を用いたシングル核RNA-Seqと空間的解析による肥大型心筋症の病態解明」(2023-2025)　

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

○Presentation and Debate(2023)
○Academic Skils(2023)
○Cardiology(2023)
○Cross-cultural Experiences(2022)
○Practice of Wellness Promotion(2019)
○Internal Medicine(BSL)(2019)
○Health Science(2019)
○Cardiovascular Medicine(2019)
○Cardiovascular Medicine(2019)
○Internal Medicine(BSL)(2018)

Classes (Graduate Schools)

International Project

International Students

Lecture themes

Others (Social Activities)

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