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last modified：2025/04/09
Professor TANIGUCHI, Hiroaki
Faculty, Affiliation
Cancer Research Institute Division of Innovative Cancer Control Research, Cancer Research Institute of Kanazawa University
Professor
College and School Educational Field
Graduate School of Medical Science
Graduate School of Medical Science
Laboratory
Division of Innovative Cancer Control Research (Clinical Oncology) TEL:076-265-2794
Academic Background
Career
Kanazawa University Hospital Clinical Oncology chief(2024/09-)
Cancer Research Institute of Kanazawa University Division of Innovative Cancer Control Research Professor(2024/08-)
Osaka University Graduate School of Medicine Division of Health Sciences, Department of Molecular Pathology(2023/07-)
(2019/05-2024/07)
University of Tsukuba(2019/04-)
Keio University School of Medicine, Clinical and Translational Research Center(2018/11-2022/03)
The University of Tokyo The Institute of Medical Science(2019/05-)
The University of Tokyo The Institute of Medical Science(2018/04-2019/03)
The University of Tokyo The Institute of Medical Science(2015/05-2018/03)
The University of Tokyo The Institute of Medical Science(2012/07-2015/06)
The University of Tokyo The Institute of Medical Science(2011/07-2012/06)
The University of Tokyo The Institute of Medical Science(2011/04-2011/06)
Sapporo Medical University(2009/04-2011/03)
IDIBELL (Bellvitge Institute for Biomedical Research; Spain, Barcelona）(2008/11-2009/03)
(2007/04-2008/10)
Sapporo Medical University(2006/04-2007/03)
Sapporo Medical University Hospital(2001/04-2002/03)
Year & Month of Birth
Academic Society
Award
Specialities
Tumor therapeutics、Tumor biology、Experimental pathology、Drug development chemistry、General internal medicine (including psychosomatic medicine)、Gastroenterology、Biomedical engineering/Biomaterial science and engineering
Speciality Keywords
oligonucleotide theraputics,molecular target therapy,cellular biology,molecular biology,cancer biology
Research Themes
Books
Papers
- Association of Ets-related transcriptional factor E1AF expression with overexpression of matrix metalloproteinases, COX-2 and iNOS in the early stage of colorectal carcinogenesis K Nosho,M Yoshida,H Yamamoto,H Taniguchi,Y Adachi,M Mikami,Y Hinoda,K Imai CARCINOGENESIS 26 5 892 2005/05
- Interplay of insulin-like growth factor-II, insulin-like growth factor-I, insulin-like growth factor-I receptor, COX-2, and matrix metalloproteinase-7, play key roles in the early stage of colorectal carcinogenesis K Nosho,H Yamamoto,H Taniguchi,Y Adachi,Y Yoshida,Y Arimura,T Endo,Y Hinoda,K Imai CLINICAL CANCER RESEARCH 10 23 7950 2004/12
- Association of matrilysin-2 (MMP-26) expression with tumor progression and activation of MMP-9 in esophageal squamous cell carcinoma H Yamamoto,A Vinitketkumnuen,Y Adachi,H Taniguchi,T Hirata,N Miyamoto,K Nosho,A Imsumran,M Fujita,M Hosokawa,Y Hinoda,K Imai CARCINOGENESIS 25 12 2353 2004/12
- Expression of ets-related transcriptional factor E1AF is associated with tumor progression and over-expression of matrilysin in human gastric cancer H Yamamoto,S Horiuchi,Y Adachi,H Taniguchi,K Nosho,YF Min,K Imai CARCINOGENESIS 25 3 325 2004/03
- Association of trypsin expression with tumour progression and matrilysin expression in human colorectal cancer H Yamamoto,S Iku,Y Adachi,A Imsumran,H Taniguchi,K Nosho,YF Min,S Horiuchi,M Yoshida,F Itoh,K Imai JOURNAL OF PATHOLOGY 199 2 176 2003/02
- Frequent epigenetic inactivation of Wnt inhibitory factor-1 in human gastrointestinal cancers H Taniguchi,H Yamamoto,T Hirata,N Miyamoto,M Oki,K Nosho,Y Adachi,T Endo,K Imai,Y Shinomura ONCOGENE 24 53 7946 2005/11
- Overexpression of poly(ADP-ribose) polymerase-1 (PARP-1) in the early stage of colorectal carcinogenesis Katsuhiko Nosho,Hiroyuki Yamamoto,Masashi Mikami,Hiroaki Taniguchi,Taiga Takahashi,Yasushi Adachi,Akimichi Imamura,Kohzoh Imai,Yasuhisa Shinomura EUROPEAN JOURNAL OF CANCER 42 14 2374 2006/09
- Transcriptional silencing of hedgehog-interacting protein by CpG hypermethylation and chromatic structure in human gastrointestinal cancer H. Taniguchi,H. Yamamoto,N. Akutsu,K. Nosho,Y. Adachi,K. Imai,Y. Shinomura JOURNAL OF PATHOLOGY 213 2 131 2007/10
- The RNA-binding protein HuR regulates DNA methylation through stabilization of DNMT3b mRNA Isabel Lopez de Silanes,Myriam Gorospe,Hiroaki Taniguchi,Kotb Abdelmohsen,Subramanya Srikantan,Miguel Alaminos,Mara Berdasco,Roco G. Urdinguio,Mario F. Fraga,Filipe V. Jacinto,Manel Esteller NUCLEIC ACIDS RESEARCH 37 8 2658 2009/05
- Overexpression of the receptor tyrosine kinase EphA4 in human gastric cancers Mariko Oki,Hiroyuki Yamamoto,Hiroaki Taniguchi,Yasushi Adachi,Kohzoh Imai,Yasuhisa Shinomura WORLD JOURNAL OF GASTROENTEROLOGY 14 37 5650 2008/10
- Transcriptional silencing of Dickkopf gene family by CpG island hypermethylation in human gastrointestinal cancer Tadateru Maehata,Hiroaki Taniguchi,Hiroyuki Yamamoto,Katsuhiko Nosho,Yasushi Adachi,Nobuki Miyamoto,Chie Miyamoto,Noriyuki Akutsu,Satoshi Yamaoka,Fumio Itoh WORLD JOURNAL OF GASTROENTEROLOGY 14 17 2702 2008/05
- Correlation of laterally spreading type and JC virus with methylator phenotype status in colorectal adenoma Katsuhiko Nosho,Hiroyuki Yamamoto,Taiga Takahashi,Masashi Mikami,Keiichi Hizaki,Tadateru Maehata,Hiroaki Taniguchi,Satoshi Yamaoka,Yasushi Adachi,Fumio Itoh,Kohzoh Imai,Yasuhisa Shinomura HUMAN PATHOLOGY 39 5 767 2008/05
- Genetic and epigenetic profiling in early colorectal tumors and prediction of invasive potential in pT1 (early invasive) colorectal cancers Katsuhiko Nosho,Hiroyuki Yamamoto,Taiga Takahashi,Masashi Mikami,Hiroaki Taniguchi,Nobuki Miyamoto,Yasushi Adachi,Yoshiaki Arimura,Fumio Itoh,Kohzoh Imai,Yasuhisa Shinomura CARCINOGENESIS 28 6 1364 2007/06
- Flat-type colorectal advanced adenomas (laterally spreading tumors) have different genetic and epigenetic alterations from protruded-type advanced adenomas Taiga Takahashi,Katsuhiko Nosho,Hiroyuki Yamamoto,Masashi Mikami,Hiroaki Taniguchi,Nobuki Miyamoto,Yasushi Adachi,Fumio Itoh,Kohzoh Imai,Yasuhisa Shinomura MODERN PATHOLOGY 20 1 139 2007/01
- Mutational analysis of beta-catenin and the RAS-RAF signalling pathway in early flat-type colorectal tumours Masashi Mikami,Katsuhiko Nosho,Hiroyuki Yamamoto,Taiga Takahashi,Tadateru Maehata,Hiroaki Taniguchi,Yasushi Adachi,Akimichi Imamura,Masahiro Fujita,Masao Hosokawa,Fumio Itoh,Kohzoh Imai,Yasuhisa Shinomura EUROPEAN JOURNAL OF CANCER 42 17 3065 2006/11
- Characterization of the immune escape phenotype of human gastric cancers with and without high-frequency microsatellite instability T. Hirata,H. Yamamoto,H. Taniguchi,S. Horiuchi,M. Oki,Y. Adachi,K. Imai,Y. Shinomura JOURNAL OF PATHOLOGY 211 5 516 2007/04
- Overexpression of beta 3/gamma 2 chains of laminin-5 and MMP7 in biliary cancer Toshikuni Oka,Hiroyuki Yamamoto,Shigeru Sasaki,Masanori Ii,Keiichi Hizaki,Hiroaki Taniguchi,Yasushi Adachi,Kohzoh Imai,Yasuhisa Shinomura WORLD JOURNAL OF GASTROENTEROLOGY 15 31 3865 2009/08
- Differential expression of angiogenesis-related genes in human gastric cancers with and those without high-frequency microsatellite instability Nobuki Miyamoto,Hiroyuki Yamamoto,Hiroaki Taniguchi,Chie Miyamoto,Mariko Oki,Yasushi Adachi,Kohzoh Imai,Yasuhisa Shinomura CANCER LETTERS 254 1 42 2007/08
- [An overview of antibody therapy against cancer]. Taniguchi H,Imai K Nihon rinsho. Japanese journal of clinical medicine 70 12 2087 2012/12
- PRDM14 is overexpressed in chronic pancreatitis prior to pancreatic cancer. Moriya C,Imai K,Taniguchi H FEBS open bio 8 10 1733 2018/10
- PRDM14 silencing by siRNA combined with an innovative nanoparticle reduced breast tumor formation and metastasis in vivo. Taniguchi H,Moriya C,Akinaga S,Kataoka K,Imai K Cancer Res 78 2018
- Genetic and epigenetic characteristics of gastric cancers with JC virus T-antigen Satoshi Yamaoka,Hiroyuki Yamamoto,Katsuhiko Nosho,Hiroaki Taniguchi,Yasushi Adachi,Shigeru Sasaki,Yoshiaki Arimura,Kohzoh Imai,Yasuhisa Shinomura WORLD JOURNAL OF GASTROENTEROLOGY 15 44 5579 2009/11
- Inhibition of PRDM14 expression in pancreatic cancer suppresses cancer stem-like properties and liver metastasis in mice Chiharu Moriya,Hiroaki Taniguchi,Kanjiro Miyata,Nobuhiro Nishiyama,Kazunori Kataoka,Kohzoh Imai CARCINOGENESIS 38 6 638 2017/06
- Cancer stem cells in human gastrointestinal cancer Hiroaki Taniguchi,Chiharu Moriya,Hisayoshi Igarashi,Anri Saitoh,Hiroyuki Yamamoto,Yasushi Adachi,Kohzoh Imai CANCER SCIENCE 107 11 1556 2016/11
- Proteolysis of EphA2 Converts It from a Tumor Suppressor to an Oncoprotein Naohiko Koshikawa,Daisuke Hoshino,Hiroaki Taniguchi,Tomoko Minegishi,Taizo Tomari,Sung-Ouk Nam,Mikiko Aoki,Takayuki Sueta,Takashi Nakagawa,Shingo Miyamoto,Kazuki Nabeshima,Alissa M. Weaver,Motoharu Seiki CANCER RESEARCH 75 16 3327 2015/08
- Insulin-like growth factor receptor expression is associated with aggressive phenotypes and has therapeutic activity in biliary tract cancers Hirokazu Ohashi,Yasushi Adachi,Hiroyuki Yamamoto,Hiroaki Taniguchi,Katsuhiko Nosho,Hiromu Suzuki,Yoshiaki Arimura,Kohzoh Imai,David P. Carbone,Yasuhisa Shinomura Cancer Science 103 2 252 2012/02
- The Efficacy of IGF-I Receptor Monoclonal Antibody against Human Gastrointestinal Carcinomas is Independent of k-ras Mutation Status Masanori Ii,Hua Li,Yasushi Adachi,Hiroyuki Yamamoto,Hirokazu Ohashi,Hiroaki Taniguchi,Yoshiaki Arimura,David P. Carbone,Kohzoh Imai,Yasuhisa Shinomura CLINICAL CANCER RESEARCH 17 15 5048 2011/08
- Association of glypican-3 expression with growth signaling molecules in hepatocellular carcinoma Noriyuki Akutsu,Hiroyuki Yamamoto,Shigeru Sasaki,Hiroaki Taniguchi,Yoshiaki Arimura,Kohzoh Imai,Yasuhisa Shinomura WORLD JOURNAL OF GASTROENTEROLOGY 16 28 3521 2010/07
- Interrelationship between microsatellite instability and microRNA in gastrointestinal cancer Hiroyuki Yamamoto,Yasushi Adachi,Hiroaki Taniguchi,Hiroaki Kunimoto,Katsuhiko Nosho,Hiromu Suzuki,Yasuhisa Shinomura WORLD JOURNAL OF GASTROENTEROLOGY 18 22 2745 2012/06
- Co-expression of laminin beta 3 and gamma 2 chains and epigenetic inactivation of laminin alpha 3 chain in gastric cancer Masanori II,Hiroyuki Yamamoto,Hiroaki Taniguchi,Yasushi Adachi,Mayumi Nakazawa,Hirokazu Ohashi,Tokuma Tanuma,Yasutaka Sukawa,Hiromu Suzuki,Shigeru Sasaki,Kohzoh Imai,Yasuhisa Shinomura INTERNATIONAL JOURNAL OF ONCOLOGY 39 3 593 2011/09
- Insulin-like growth factor receptor expression is associated with aggressive phenotypes and has therapeutic activity in biliary tract cancers Hirokazu Ohashi,Yasushi Adachi,Hiroyuki Yamamoto,Hiroaki Taniguchi,Katsuhiko Nosho,Hiromu Suzuki,Yoshiaki Arimura,Kohzoh Imai,David P. Carbone,Yasuhisa Shinomura CANCER SCIENCE 103 2 252 2012/02
- A DNA methylation fingerprint of 1628 human samples Agustin F. Fernandez,Yassen Assenov,Jose Ignacio Martin-Subero,Balazs Balint,Reiner Siebert,Hiroaki Taniguchi,Hiroyuki Yamamoto,Manuel Hidalgo,Aik-Choon Tan,Oliver Galm,Isidre Ferrer,Montse Sanchez-Cespedes,Alberto Villanueva,Javier Carmona,Jose V. Sanchez-Mut,Maria Berdasco,Victor Moreno,Gabriel Capella,David Monk,Esteban Ballestar,Santiago Ropero,Ramon Martinez,Marta Sanchez-Carbayo,Felipe Prosper,Xabier Agirre,Mario F. Fraga,Osvaldo Grana,Luis Perez-Jurado,Jaume Mora,Susana Puig,Jaime Prat,Lina Badimon,Annibale A. Puca,Stephen J. Meltzer,Thomas Lengauer,John Bridgewater,Christoph Bock,Manel Esteller GENOME RESEARCH 22 2 407 2012/02
- Epigenetic inactivation of calcium-sensing receptor in colorectal carcinogenesis Keiichi Hizaki,Hiroyuki Yamamoto,Hiroaki Taniguchi,Yasushi Adachi,Mayumi Nakazawa,Tokuma Tanuma,Norihiro Kato,Yasutaka Sukawa,Jose V. Sanchez,Hiromu Suzuki,Shigeru Sasaki,Kohzoh Imai,Yasuhisa Shinomura MODERN PATHOLOGY 24 6 876 2011/06
- Epigenetic Inactivation of the Circadian Clock Gene BMAL1 in Hematologic Malignancies Hiroaki Taniguchi,Agustin F. Fernandez,Fernando Setien,Santiago Ropero,Esteban Ballestar,Alberto Villanueva,Hiroyuki Yamamoto,Kohzoh Imai,Yasuhisa Shinomura,Manel Esteller CANCER RESEARCH 69 21 8447 2009/11
- PRDM14, a Zinc Finger Protein, Regulates Cancer Stemness. Taniguchi H,Imai K Methods in molecular biology (Clifton, N.J.) 1867 3 2018
- [Prevention of tumour invasion]. Daisuke Hoshino,Naohiko Koshikawa,Motoharu Seiki,Hiroaki Taniguchi Nihon rinsho. Japanese journal of clinical medicine 70 Suppl 8 154 2012/11
- Silencing of Kruppel-like factor 2 by the histone methyltransferase EZH2 in human cancer H. Taniguchi,F. V. Jacinto,A. Villanueva,A. F. Fernandez,H. Yamamoto,F. J. Carmona,S. Puertas,V. E. Marquez,Y. Shinomura,K. Imai,M. Esteller ONCOGENE 31 15 1988 2012/04
- Cancer detection by ubiquitin carboxyl-terminal esterase L1 methylation in pancreatobiliary fluids Norihiro Kato,Hiroyuki Yamamoto,Yasushi Adachi,Hirokazu Ohashi,Hiroaki Taniguchi,Hiromu Suzuki,Mayumi Nakazawa,Hiroyuki Kaneto,Shigeru Sasaki,Kohzoh Imai,Yasuhisa Shinomura WORLD JOURNAL OF GASTROENTEROLOGY 19 11 1718 2013/03
- An updated review of gastric cancer in the next-generation sequencing era: Insights from bench to bedside and vice versa Hiroyuki Yamamoto,Yoshiyuki Watanabe,Tadateru Maehata,Ryo Morita,Yoshihito Yoshida,Ritsuko Oikawa,Shinya Ishigooka,Shun-ichiro Ozawa,Yasumasa Matsuo,Kosuke Hosoya,Masaki Yamashita,Hiroaki Taniguchi,Katsuhiko Nosho,Hiromu Suzuki,Hiroshi Yasuda,Yasuhisa Shinomura,Fumio Itoh WORLD JOURNAL OF GASTROENTEROLOGY 20 14 3927 2014/04
- Silencing PRDM14 via Oligonucleotide Therapeutics Suppresses Tumorigenicity and Metastasis of Breast Cancer. Hiroaki Taniguchi,Kohzoh Imai Methods in molecular biology (Clifton, N.J.) 1974 233 2019
- PRDM14 directly interacts with heat shock proteins HSP90α and glucose-regulated protein 78 Chiharu Moriya,Hiroaki Taniguchi,Satoru Nagatoishi,Hisayoshi Igarashi,Kouhei Tsumoto,Kohzoh Imai Cancer Science 109 2 373 2018/02/01
- Silencing PRDM14 expression by an innovative RNAi therapy inhibits stemness, tumorigenicity, and metastasis of breast cancer Hiroaki Taniguchi,Daisuke Hoshino,Chiharu Moriya,Hitoshi Zembutsu,Nobuhiro Nishiyama,Hiroyuki Yamamoto,Kazunori Kataoka,Kohzoh Imai ONCOTARGET 8 29 46856 2017/07
- The effect of IGF-I receptor blockade for human esophageal squamous cell carcinoma and adenocarcinoma Yasushi Adachi,Hirokazu Ohashi,Arisa Imsumran,Hiroyuki Yamamoto,Yasutaka Matsunaga,Hiroaki Taniguchi,Katsuhiko Nosho,Hiromu Suzuki,Yasushi Sasaki,Yoshiaki Arimura,David P. Carbone,Kohzoh Imai,Yasuhisa Shinomura TUMOR BIOLOGY 35 2 973 2014/02
- Knockdown of 15-bp Deletion-Type v-raf Murine Sarcoma Viral Oncogene Homolog B1 mRNA in Pancreatic Ductal Adenocarcinoma Cells Repressed Cell Growth In Vitro and Tumor Volume In Vivo Jiaxuan Song,Yoshiaki Kobayashi,Yoshimasa Asano,Atsushi Sato,Hiroaki Taniguchi,Kumiko Ui-Tei Cancers 14 13 3162 2022/06/28 ?
- Therapeutic siRNA targeting the cancer cell stemness regulator PRDI-BF1 and RIZ domain zinc finger protein 14 Kohzoh IMAI,Hiroaki TANIGUCHI Proceedings of the Japan Academy, Series B 98 7 325 2022/07/29 ?
- RT-PCR Screening Tests for SARS-CoV-2 with Saliva Samples in Asymptomatic People: Strategy to Maintain Social and Economic Activities while Reducing the Risk of Spreading the Virus. Junna Oba,Hiroaki Taniguchi,Masae Sato,Reika Takamatsu,Satoru Morikawa,Taneaki Nakagawa,Hiromasa Takaishi,Hideyuki Saya,Koichi Matsuo,Hiroshi Nishihara The Keio journal of medicine 70 2 35 2021/06/25
- PRDM14 promotes malignant phenotype and correlates with poor prognosis in colorectal cancer H. Igarashi,H. Taniguchi,K. Nosho,K. Ishigami,H. Koide,K. Mitsuhashi,K. Okita,I. Takemasa,K. Imai,H. Nakase Clinical and Translational Oncology 22 7 1126 2020/07
- SARS-CoV-2 RT-qPCR testing of pooled saliva samples: A case study of 824 asymptomatic individuals and a questionnaire survey in Japan. Junna Oba,Hiroaki Taniguchi,Masae Sato,Masaki Takanashi,Moe Yokemura,Yasunori Sato,Hiroshi Nishihara PloS one 17 5 e0263700 2022/05
- The Evolving Landscape of Cancer Stem Cells and Ways to Overcome Cancer Heterogeneity. Taniguchi H,Suzuki Y,Natori Y Cancers 11 4 2019/04
- Antitumoral RNA‐targeted oligonucleotide therapeutics: The third pillar after small molecule inhibitors and antibodies Hiroaki Taniguchi,Yasunori Suzuki,Kohzoh Imai,Yasushi Adachi Cancer Science 2022/07/11
- Treatment of primary and metastatic breast and pancreatic tumors upon intravenous delivery of a PRDM14-specific chimeric siRNA/nanocarrier complex. Hiroaki Taniguchi,Yukikazu Natori,Yohei Miyagi,Kotaro Hayashi,Fumitaka Nagamura,Kazunori Kataoka,Kohzoh Imai International journal of cancer 149 3 646 2021/08/01
- Analysis of Methylation of Tumor-suppressive miRNAs and KRAS/TP53 Mutations in Pancreatic Juice. Ohtsubo K, Miyake K, Sato S, Sakaguchi H, Fukuda K, Kotani H, Nishiyama A, Nanjo S, Yamashita K, Takeuchi S, Yano S, Kuruma S, Nakahodo J, Kikuyama M, Taniguchi H. Anticancer Res 44 12 5253-5261 2024/11
Conference Presentations
Others
Arts and Fieldwork
Patent
Theme to the desired joint research
Grant-in-Aid for Scientific Research
○「多分子標的型核酸と高性能化DDSによって転移性癌をリセットするムーンショット計画」(2024-2026)
○「癌幹細胞性を担うPRDM14分子の蛋白質相互作用に基づく機能解明と抗腫瘍薬の開発
」(2016-2018)
○「新規がん幹細胞特異的マーカーの同定」(2013-2014)
○「癌幹細胞を制御する転写因子を標的とした難治性乳癌治療法の開発」(2012-2014)
○「大規模エピゲノム解析に基づく革新的消化器がん診断法の開発」(2011-2013)
○「幹細胞様腫瘍細胞の形質を制御する新規経路の同定とがん治療への応用」(2011-2012)
Competitive research funding,Contribution
Collaborative research,Consignment study
Classes (Bachelors)
○Oncology(2024)
○Clinical Clerkship（Oncology）(2024)
○Clinical Clerkship（Oncology）(2024)
○Clinical Clerkship（Oncology）(2024)
○Clinical Clerkship（Oncology）(2024)
○Clinical Clerkship（Oncology）(2024)
○Clinical Clerkship（Oncology）(2024)
○Clinical Clerkship（Oncology）(2024)
○Clinical Clerkship（Oncology）(2024)
Classes (Graduate Schools)
○Innovative Cancer Treatment(2024)