last modified：2025/12/05
Professor TAKIKAWA, Hiroshi
Faculty, Affiliation
Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences
College and School Educational Field
Laboratory
Bioorganic and Molecular Chemisitry Laboratory TEL:076-264-6201
Academic Background
【Degree】
B.S. of Engineering
M.S. of Science
Ph.D. of Science
Career
Japan Society for the Promotion of Science Research Fellowships for Young Scientists (DC1)(2005/04-2008/03)
Max-Planck-Institut für Kohlenforschung, Germany Postdoctoral Fellow(2008/04-2009/03)
Japan Society for the Promotion of Science Research Fellowships for Young Scientists (PD)(2008/04-2009/03)
Tokyo Institute of Technology Department of Chemistry Assistant Professor(2009/04-2016/03)
Tokyo Institute of Technology Department of Chemistry Assistant Professor(2016/04-2017/05)
Kyoto University Graduate School of Pharmaceutical Sciences Lecturer(2017/05-2023/10)
Ministry of Education, Culture, Sports, Science and Technology (MEXT), Japan Research Promotion Bureau Program Officer(2021/08-2023/07)
Kyoto University Graduate School of Pharmaceutical Sciences Associate Professor(2023/11-2025/05)
Kanazawa University Institute of Medical, Pharmaceutical and Health Sciences Faculty of Pharmacy Professor(2025/06-)
Year & Month of Birth
1980/08
Academic Society
THE PHARMACEUTICAL SOCIETY OF JAPAN
The Chemical Society of Japan
The Society of Synthetic Organic Chemistry
KINKI CHEMICAL SOCIETY, JAPAN
JAPANESE SOCIETY FOR CHEMICAL BIOLOGY
Award
○26th Inoue Research Award for Young Scientists(2009/12)
○26th Inoue Research Award for Young Scientists(2009/12)
○BCSJ Award Article(2016/08)
○The 32th Special Young LecturerSpecial Young Lecturer in the 98th CSJ Annual Meeting(2018/03)
○Incentive Award in Synthetic Organic Chemistry(2019/12)
○Shionogi Pharma Co. Award in Synthetic Organic Chemistry(2020/12)
○Journals Award 2021(2020/12)
Specialities
Organic chemistry、Structural/Functional materials、Chemical pharmacy、Bioorganic chemistry
Speciality Keywords
Research Themes
Books
- Masataka Oishi,Hiroshi Takikawa Science of Synthesis Knowledge Updates Georg Thieme Verlag KG 2010
- Keisuke Suzuki,Hiroshi Takikawa Science of Synthesis; Asymmetric Organocatalysts 1 Georg Thieme, Verlag KG 2011
- Hiroshi Takikawa,Keisuke Suzuki Modern Aryne Chemistry Wiley-VCH 2021/08
Papers
- Asymmetric vinylogous direct aldol reaction using aluminum tris[2,6-bis(4-alkylphenyl)phenoxide] H Takikawa,K Ishihara,S Saito,H Yamamoto SYNLETT 4 732 2004/03
- Catalytic enantioselective crossed aldehyde-ketone benzoin cyclization Hiroshi Takikawa,Yoshifumi Hachisu,Jeffrey W. Bode,Keisuke Suzuki ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 45 21 3492 2006
- Intramolecular Benzyne-Phenolate [4+2] Cycloadditions. Hiroshi Takikawa,Arata Nishii,Hiromu Takiguchi,Hirotoshi Yagishita,Masato Tanaka,Keiichi Hirano,Masanobu Uchiyama,Ken Ohmori,Keisuke Suzuki Angewandte Chemie (International ed. in English) 59 30 12440 2020/04/09
- Synthesis of beta-Hydroxynaphthoate Derivatives from Ketodioxinones via Benzyne Acyl-Alkylation and Aldol Condensation Cascade Hiroshi Takikawa,Arata Nishii,Keisuke Suzuki SYNTHESIS-STUTTGART 48 19 3331 2016/10
- Pleospdione, A Tricyclic Natural Product with Dense Oxygenation at the A-Ring: Total Synthesis and Incongruity of the Originally Assigned Structure and its C3-Epimer Hiroshi Takikawa,Yui Ishikawa,Yuki Yoshinaga,Yoshimitsu Hashimoto,Takenori Kusumi,Keisuke Suzuki BULLETIN OF THE CHEMICAL SOCIETY OF JAPAN 89 8 941 2016/08
- Concise Total Syntheses of Amphidinolides C and F Gaelle Valot,Damien Mailhol,Christopher S. Regens,Daniel P. O'Malley,Edouard Godineau,Hiroshi Takikawa,Petra Philipps,Alois Fuerstner CHEMISTRY-A EUROPEAN JOURNAL 21 6 2398 2015/02
- Isoxazole Platform for Polyketide Assembly: Cycloaddition of Stable Benzonitrile Oxides to Stable ortho-Quinone Monoacetals and Dehydrogenation Hiroshi Takikawa,Yoshimitsu Hashimoto,Keisuke Suzuki CHEMISTRY LETTERS 43 10 1607 2014/10
- Total Synthesis of Amphidinolide F Gaelle Valot,Christopher S. Regens,Daniel P. O'Malley,Edouard Godineau,Hiroshi Takikawa,Alois Fuerstner ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 52 36 9534 2013/09
- Total Synthesis of the Antibiotic BE-43472B Yu Yamashita,Yoichi Hirano,Akiomi Takada,Hiroshi Takikawa,Keisuke Suzuki ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 52 26 6658 2013
- Synthesis of isoxazoles en route to semi-aromatized polyketides: dehydrogenation of benzonitrile oxide-para-quinone acetal cycloadducts Yoshimitsu Hashimoto,Akiomi Takada,Hiroshi Takikawa,Keisuke Suzuki ORGANIC & BIOMOLECULAR CHEMISTRY 10 30 6003 2012
- Total Synthesis and Absolute Stereochemistry of Seragakinone A Akiomi Takada,Yoshimitsu Hashimoto,Hiroshi Takikawa,Katsuyoshi Hikita,Keisuke Suzuki ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 50 10 2297 2011
- Formation of alpha-hydroxy-beta-diketones through hydroxylation of isoxazolium salts: Stereoselective approach to angular cis-diols in polycyclic systems Hiroshi Takikawa,Akionii Takada,Katsuyoshi Hikita,Keisuke Suzuki ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 47 39 7446 2008
- Synthesis of highly functionalized isoxazoles via base-promoted cyclocondensation of stable nitrile oxides with active methylene compounds Hiroshi Takikawa,Katsuyoshi Hikita,Keisuke Suzuki SYNLETT 14 2252 2007/09
- Modified chiral triazolium salts for enantioselective benzoin cyclization of enolizable keto-aldehydes: Synthesis of (+)-sappanone B Hiroshi Takikawa,Keisuke Suzuki ORGANIC LETTERS 9 14 2713 2007/07
- Helical Nanographenes Embedded with Contiguous Azulene Units Naoki Ogawa,Yousuke Yamaoka,Hiroshi Takikawa,Ken-ichi Yamada,Kiyosei Takasu Journal of the American Chemical Society 142 31 13322 2020/07/17
- Aryne-based strategy in the total synthesis of naturally occurring polycyclic compounds Takikawa Hiroshi,Nishii Arata,Sakai Takahiro,Suzuki Keisuke CHEMICAL SOCIETY REVIEWS 47 21 8030 2018/11/07
- Isoxazole-Assisted Direct Substitution of the Hydroxy Group in alpha-Ketols: Introduction of Angular Substituents in a Polycyclic System Hiroshi Takikawa,Katsuyoshi Hikita,Keisuke Suzuki ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 47 51 9887 2008
- Synthetic Study on Lactonamycins, Part 2: Stereoselective Access to ABCD-Ring System Keisuke Suzuki,Hiroshi Takikawa,Kazuki Murata,Shogo Sato,Takuma Kawada,Hiroshi Nakakohara,Ken Ohmori Synlett 31 16 1623 2020/07/21
- Synthesis of Dibenzoxazonines by Domino [2+2] Cycloaddition—4π Electrocyclic Ring Opening Reaction of Cyclic Imines with Ynamides Kiyosei Takasu,Masaki Tsutsumi,Tomohiro Ito,Hiroshi Takikawa,Yousuke Yamaoka HETEROCYCLES 101 2 423 2020
- Total Syntheses of Allelopathic 4-Oxyprotoilludanes, Melleolides, and Echinocidins Shimoda K,Yamaoka Y,Yoo D,Yamada KI,Takikawa H,Takasu K The Journal of Organic Chemistry 84 17 11014 2019/09
- Synthesis of Polycyclic Spirocarbocycles via Acid-Promoted Ring-Contraction/Dearomative Ring-Closure Cascade of Oxapropellanes Ogawa N,Yamaoka Y,Takikawa H,Takasu K Organic Letters 21 18 7563 2019/09
- Synthesis of Functionalized Medium-Sized trans -Cycloalkenes by 4π Electrocyclic Ring Opening/Alkylation Sequence Tomohiro Ito,Masaki Tsutsumi,Ken-ichi Yamada,Hiroshi Takikawa,Yousuke Yamaoka,Kiyosei Takasu Angewandte Chemie International Edition 58 34 11836 2019/08
- 2-Bromo-6-(chlorodiisopropylsilyl)phenyl tosylate as an efficient platform for intramolecular benzyne-diene [4+2] cycloaddition Nishii Arata,Takikawa Hiroshi,Suzuki Keisuke CHEMICAL SCIENCE 10 13 3840 2019/04/07
- Synthetic Strategy toward Dearomatized Polycyclic Polyketide Natural Products Hiroshi Takikawa,Keisuke Suzuki Journal of Synthetic Organic Chemistry, Japan 77 1 13 2019/01/01
- Total Synthesis of Bis-anthraquinone Antibiotic BE-43472B Yu Yamashita,Yoichi Hirano,Akiomi Takada,Hiroshi Takikawa,Keisuke Suzuki Synthesis (Germany) 50 13 2490 2018/07/02
- Synthesis and Properties of Tribenzocarbazoles via an Acid-Promoted Retro (2+2)-Cycloaddition of Azapropellanes Naoki Ogawa,Yousuke Yamaoka,Hiroshi Takikawa,Kazunori Tsubaki,Kiyosei Takasu The Journal of Organic Chemistry 83 15 7994 2018/06
- Trial and Error in Total Synthesis of Polyketide-derived Polycyclic Natural Products Hiroshi Takikawa Journal of Synthetic Organic Chemistry, Japan 76 5 478 2018/05/01
- First Total Syntheses of Tetracenomycins C and X Shogo Sato,Keiichiro Sakata,Yoshimitsu Hashimoto,Hiroshi Takikawa,Keisuke Suzuki ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 56 41 12608 2017/10
- Preparation of 2-Substituted 3-Methoxycarbonyl-4-methoxyfurans that Allow Access to Highly Functionalized Naphthalenes via Regioselective Cycloaddition with Alkoxybenzyne Shogo Sato,Takuma Kawada,Hiroshi Takikawa,Keisuke Suzuki SYNLETT 28 14 1719 2017/09
- Oxidative Ring Opening of Benzocyclobutenone Oximes: Novel Access to Stable Nitrile Oxides Hiroshi Takikawa,Shogo Sato,Ryota Seki,Keisuke Suzuki CHEMISTRY LETTERS 46 7 998 2017/07
- Synthetic Study on Acremoxanthone A: Construction of Bicyclo [3.2.2]nonane CD Skeleton and Fusion of AB Rings Yoichi Hirano,Kensei Tokudome,Hiroshi Takikawa,Keisuke Suzuki SYNLETT 28 2 214 2017/01
- Structure–ATPase Activity Relationship of Rhodamine Derivatives as Potent Inhibitors of P-Glycoprotein CmABCB1 Sorachi Miwa,Hiroshi Takikawa,Rina Takeuchi,Ryo Mizunuma,Keita Matsuoka,Haruo Ogawa,Hiroaki Kato,Kiyosei Takasu ACS Medicinal Chemistry Letters 15 2 287 2024/01/19
- Sequential Bromination/Dearomatization Reactions of 2-Methoxyphenols en route to Bromo-Substituted ortho-Quinonemonoacetals Kiyosei Takasu,Hiroshi Takikawa,Shunya Hayashi Synlett 35 04 474 2023/08/11
- Intramolecular Ynamide-Benzyne (3+2) Cycloadditions Tsukasa Tawatari,Ritsuki Kato,Riku Kudo,Kiyosei Takasu,Hiroshi Takikawa Angewandte Chemie (International ed. in English) e202300907 2023/03/09
- Synthesis of Lactone-Fused Cyclopropanes by Ring Contractive α-Ketol Rearrangement of Ketal-Fused Cyclobutanones Kiyosei Takasu,Koichi Shigenaga,Kazuma Shimoda,Hiroshi Takikawa,Yousuke Yamaoka HETEROCYCLES 103 1 177 2021
- Intramolecular Propargylic Ene Reaction of Benzyne En Route to Highly Functionalized Allenes and Allenamides Kiyosei Takasu,Hiroshi Takikawa,Tsukasa Tawatari,Ritsuki Kato Synthesis 54 22 4979 2022/04/14
- 2-(Chlorodiisopropylsilyl)-6-(trimethylsilyl)phenyl triflate: a modified platform for intramolecular benzyne cycloadditions Tsukasa Tawatari,Kiyosei Takasu,Hiroshi Takikawa CHEMICAL COMMUNICATIONS 57 89 11863 2021/11
- Synthetic Study on Acremoxanthone A, Part 2: Model Study on the EFG Xanthone Moiety through a Nitrile Oxide Cycloaddition–SNAr Sequence Keisuke Suzuki,Hiroshi Nakakohara,Yoichi Hirano,Ken Ohmori,Hiroshi Takikawa Synlett 2020/11/04
- Oxidative β-Cleavage of Fused Cyclobutanols Leading to Hydrofuran-Fused Polycyclic Aromatic Compounds Hayate Kinouchi,Kazuma Sugimoto,Yousuke Yamaoka,Hiroshi Takikawa,Kiyosei Takasu The Journal of Organic Chemistry 2021/09/17
- Helicene-Fluorescein Hybrids: A Reversible Base-triggered (Chir)optical Switch with Sign Inversion of Circularly Polarized Luminescence. Sorachi Miwa,Daichi Mizutani,Kenichi Kawano,Katsumi Matsuzaki,Yuuya Nagata,Kazunori Tsubaki,Kiyosei Takasu,Hiroshi Takikawa Chemistry (Weinheim an der Bergstrasse, Germany) e202500335 2025/01/30
- Continuous flow synthesis of cyclobutenes via lithium ynolates Aki Kohyama,Motoki Namioka,Hiroshi Naka,Yosuke Ashikari,Aiichiro Nagaki,Hiroshi Takikawa,Yousuke Yamaoka,Kiyosei Takasu Green Chemistry 27 10 2760 2025
- Arylative double bond transposition of allylic alcohols via silicon-tethered intramolecular benzyne–ene reactions Ritsuki Kato,Takaya Sakaue,Tsukasa Tawatari,Kiyosei Takasu,Hiroshi Takikawa Chemical Communications 61 46 8347 2025
- Benzyne Platform: A Strategic Approach to Developing Novel Intramolecular Reactions Hiroshi Takikawa Journal of Synthetic Organic Chemistry, Japan 83 2 131 2025/02/01
- Chromic properties of dibenzo[j,l]fluoranthenes exhibiting different resonance contributions. Kazuma Kurokawa,Naoki Ogawa,Yusuke Kuroda,Yousuke Yamaoka,Hiroshi Takikawa,Kazunori Tsubaki,Kiyosei Takasu Organic & biomolecular chemistry 2024/05/30
- Synthesis of γ-Aryl Medium-Sized Cyclic Enones by a Domino 4π-Electrocyclic Reaction/Heck–Matsuda Arylation Sequence at Ambient Temperature Kiyosei Takasu,Tomohiro Ito,Nao Takeuchi,Yousuke Yamaoka,Hiroshi Takikawa Synlett 34 11 1275 2023/02/01
- Isoxazole-directed pinacol rearrangement: Stereocontrolled approach to angular stereogenic centers Keisuke Suzuki,Hiroshi Takikawa,Yoshifumi Hachisu,Jeffrey W. Bode ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 46 18 3252 2007