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Researcher Information

last modified：2026/03/14

Associate Professor　KOSUGI, Takahiro

Mail

Faculty, Affiliation

Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences

College and School Educational Field


Laboratory

Biomolecular Design Laboratory　TEL:076-264-6266

Academic Background

Career

Kanazawa University　Institute of Medical, Pharmaceutical and Health Sciences Faculty of Pharmacy　Associate Professor(2026/03-)
Institute for Molecular Science　Research Center of Integrative Molecular Systems(2015/06-2026/02)
(2012/04-2015/05)

Year & Month of Birth

Academic Society

Award

○Morino Foundation for Molecular Science(2025/09)
○The 26th Enzyme Application Symposium Research Encouragement Award(2025/06)
○13th National Institutes of Natural Sciences Young Researcher Award(2024/07)
○Protein Science Society of Japan Young Scientist Excellence Award 2021(2021/06)
○Protein Science Society of Japan Young Scientist Excellence Award 2021(2021/06)
○Protein Science Society of Japan Young Scientist Excellence Award 2021(2021/06)

Specialities

Speciality Keywords

Research Themes

Books

Papers

  • 　De novo design of ATPase based on a blueprint optimized for harboring the P‐loop motif　Takahiro Kosugi,Mikio Tanabe,Nobuyasu Koga　Protein Science　2025/06
  • 　Structure-based engineering of Tor complexes reveals that two types of yeast TORC1 produce distinct phenotypes　Yoshiaki Kamada,Chiharu Umeda,Yukio Mukai,Hokuto Ohtsuka,Yoko Otsubo,Akira Yamashita,Takahiro Kosugi　Journal of Cell Science　137　4　2024/02/15　
  • 　Design of complicated all-α protein structures　Koya Sakuma,Naohiro Kobayashi,Toshihiko Sugiki,Toshio Nagashima,Toshimichi Fujiwara,Kano Suzuki,Naoya Kobayashi,Takeshi Murata,Takahiro Kosugi,Rie Tatsumi-Koga,Nobuyasu Koga　Nature Structural & Molecular Biology　31　2　275　2024/01/04　
  • 　Design of allosteric sites into rotary motor V1-ATPase by restoring lost function of pseudo-active sites　Takahiro Kosugi,Tatsuya Iida,Mikio Tanabe,Ryota Iino,Nobuyasu Koga　Nature Chemistry　15　11　1591　2023/07/06　
  • 　Robust folding of a de novo designed ideal protein even with most of the core mutated to valine　Rie Koga,Mami Yamamoto,Takahiro Kosugi,Naohiro Kobayashi,Toshihiko Sugiki,Toshimichi Fujiwara,Nobuyasu Koga　Proceedings of the National Academy of Sciences　117　49　31149　2020/11/23

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  • 　ShadowR: a novel chromoprotein with reduced non-specific binding and improved expression in living cells.　Murakoshi H,Horiuchi H,Kosugi T,Onda M,Sato A,Koga N,Nabekura J　Scientific reports　9　1　12072　2019/08　
  • 　QM/MM Geometry Optimization on Extensive Free-Energy Surfaces for Examination of Enzymatic Reactions and Design of Novel Functional Properties of Proteins　Shigehiko Hayashi,Yoshihiro Uchida,Taisuke Hasegawa,Masahiro Higashi,Takahiro Kosugi,Motoshi Kamiya　ANNUAL REVIEW OF PHYSICAL CHEMISTRY, VOL 68　68　135　2017
  • 　Theoretical Study on Excited States of Bacteriochlorophyll a in Solutions with Density Functional Assessment　Masahiro Higashi,Takahiro Kosugi,Shigehiko Hayashi,Shinji Saito　JOURNAL OF PHYSICAL CHEMISTRY B　118　37　10906　2014/09
  • 　Crucial Role of Protein Flexibility in Formation of a Stable Reaction Transition State in an alpha-Amylase Catalysis　Takahiro Kosugi,Shigehiko Hayashi　JOURNAL OF THE AMERICAN CHEMICAL SOCIETY　134　16　7045　2012/04
  • 　QM/MM Reweighting Free Energy SCF for Geometry Optimization on Extensive Free Energy Surface of Enzymatic Reaction　Takahiro Kosugi,Shigehiko Hayashi　JOURNAL OF CHEMICAL THEORY AND COMPUTATION　8　1　322　2012/01
  • 　Local entropy difference upon a substrate binding of a psychrophilic alpha-amylase and a mesophilic homologue　Takahiro Kosugi,Shigehiko Hayashi　CHEMICAL PHYSICS LETTERS　501　4-6　517　2011/01
  • 　Binding Free Energy Calculations of Adenosine Deaminase Inhibitor and the Effect of Methyl Substitution in Inhibitors　Takahiro Kosugi,Isao Nakanishi,Kazuo Kitaura　JOURNAL OF CHEMICAL INFORMATION AND MODELING　49　3　615　2009/03

Conference Presentations

  • さきがけにおける挑戦 −タンパク質デザインによる高次構造体の理解と制御−(conference：Emerging Life Science, Pioneered by Young Minds)(2026/02/14)
  • Toward Rational Control of Concerted Protein Functions through Computational Protein Design(conference：The 12th Asian Biophysics Association (ABA) Symposium)(2026/01/13)
  • Control of protein complexes through computational protein design methods(conference：Pacifichem 2025 "Polypeptide Folding and Assembly for the Materials Design and Therapeutic Applications")(2025/12/17)
  • Toward rational control of cellular functions through customization of concerted protein functions(conference：SMART Symposium: 2025 Frontier in Computational Chemistry, Biophysics, and Biological Sciences)(2025/10/26)
  • Nature-inspired Computational Design Strategy for Rational Control of Protein Complexes(conference：27th iCeMS International Symposium “Self-Assembly Science for Unlocking Life’s Secrets”)(2025/10/03)

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  • Protein Design: From Structure to Function—Unlocking Future Applications(conference：TSUKUBA CONFERENCE 2025)(2025/10/02)
  • Control of concerted functions exerted by protein complexes using computational protein design(conference：Korea-Japan International Symposium on Protein Science)(2025/06/21)
  • Computational Protein Structure Prediction and Design(conference：UK-Japan FoS 2025)(2025/06/19)
  • Control of concerted protein functions using computational protein design(conference：Protein Science And Engineering in The New Era)(2025/04/29)
  • Toward controlling energy conversion and signaling proteins using computational protein design(conference：IPR Seminar 2025 (International); Functions, structures and dynamics of energy conversion and signaling proteins -The latest research and future works from early and mid-career scientists-)(2025/04/15)
  • Creation and control of ATPase by computational protein design(conference：Protein Trajectories Symposium)(2024/12/16)
  • Toward understanding roles of yeast TOR complexes by structure-based rational engineering approach(conference：The 47th Annual Meeting of the Molecular Biology Society of Japan)(2024/11/29)
  • Understanding and controlling functions of protein complexes by computational protein design(conference：2024 Frontier Symposium in Computational Chemistry, Biophysics, and Biological Sciences)(2024/11/08)
  • Protein Design: Computational Designs and their Experimental Validations(conference：The 97th Annual Meeting of the Japanese Biochemical Society, Symposium "Beyond the molecular movies")(2024/11/07)
  • Diffraction method for current and future protein design(conference：Diffraction Methods in Structural Biology 2024)(2024/07/27)
  • Allosteric control of rotary molecular motor by using protein design method(conference：OIST-JST JOINT MEETING)(2024/01/19)
  • Control of functions exerted by protein complexes using protein design methods(conference：16th Eurasia Conference on Chemical Sciences 2023)(2023/12/13)
  • Toward developing a new field of biology based on protein design(conference：The 2157th NIG Biological Symposium)(2023/11/20)
  • Toward understanding role of yeast Tor complexes by structure-based engineering approach(conference：The 61st Annual Meeting of the Biophysics Society of Japan, Symposium "Uncovering the mechanisms of cell response by TOR complexes")(2023/11/15)
  • Allosteric control of rotary molecular motor V1-ATPase by redesigning pseudo-active sites(conference：The East Asia Single-Molecule Biology Symposium 2023 (EASMB 2023))(2023/09/22)
  • Toward rational control of concerted functions by protein complexes(conference：The 23rd Annual Meeting of the Protein Science Society of Japan, Symposium "Accelerating Protein Design and Engineering")(2023/07/05)
  • Toward rational control of concerted functions by supramolecular assemblies(conference：The 60th Annual Meeting of the Biophysical Society of Japan: Uncovering the design principles of supramolecular assemblies through manipulation of the structures, dynamics, and functions)(2022/09/28)
  • Allosteric control of rotary molecular motor by redesigning non-catalytic interface(conference：Sendai2022 Workshop)(2022/08/04)
  • Design of a Novel Protein with a Function(conference：The 22nd Annual Meeting of the Protein Science Society of Japan)(2022/06/09)
  • Toward Biology that Starts with Protein (Computational) Science(conference：The 22nd Annual Meeting of the Protein Science Society of Japan)(2022/06/07)
  • Allosteric Regulation of V1-ATPase by Designing Walker Motif in Non-catalytic Interface(conference：2nd Tokyo ATPase Workshop)(2019/09/30)
  • Design of Allosteric Site to Regulate Rotary Molecular Motor V1-ATPase(2019/07/08)
  • Rational Design of ATP Binding Site; An Attempt to Understand Molecular Motor(conference：The 56th Annual Meeting of The Biophysical Society of Japan 「Designing biological systems from scratch」)(2018/09/16)
  • Rational Design of ATP Binding Site to Understand Rotary Molecular Motor(conference：The 79th Okazaki Conference 「Synthetic, Biological, and Hybrid Molecular Engines」)(2018/09/01)
  • Design of ATP Binding Site from Scratch and in V1-ATPase(conference：The 17th Annual Meeting of the Protein Science Society of Japan 「Science of mobility-coupled functional molecular machines」)(2017/06/22)
  • Design of Nucleotide Binding Site Toward Controlling and Understanding Molecular Motor(conference：The 56th Annual Meeting of The Biophysical Society of Japan 「Synthetic biology approaches to understand biological molecules, complexes, and networks」)(2016/11/26)
  • Protein Design from Scratch: from Structure to Function(conference：The 96th CSJ Annual Meeting International, Symposium on Molecular Science - Physical Chemistry / Theoretical Chemistry, Chemoinformatics, Computational Chemistry -)(2016/03/26)
  • De novo design of protein function(conference：8th Japan-Korea Seminars on Biomolecular Science: Experiments and Simulation)(2016/02/17)

Others

  • 　再定義されるタンパク質の常識 合理デザインによる新規タンパク質の創出:現状とその可能性　小杉貴洋,古賀理恵,古賀信康　実験医学　37　18　3089‐3095　2019/11
  • 　The era of designing proteins completely from scratch　古賀理恵,小杉貴洋,古賀信康　実験医学　40　12　2046　2022
  • 　Develop a Strategy to Design Artificial Allosteric Sites in Protein Complexes - Rate Acceleration of Rotary Molecular Motor -　Takahiro Kosugi,Nobuyasu Koga　Photon Factory Highlights 2023　24　2024/12
  • 　Structural Analysis for Engineering Protein and Interpreting its Mechanism　Takahiro Kosugi　PHOTON FACTORY NEWS　42　1　2024/05

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「調節分子の違いが生み出すアロステリーの向上と拡張」(2024-2028)　
○「還元的手法と構成的手法を組合せた蛍光蛋白質の設計原理の解析と新規蛍光蛋白質開発」(2024-2027)　

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

Classes (Graduate Schools)

International Project

International Students

Lecture themes

Others (Social Activities)

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