Specialities

Experimental pathology

Speciality Keywords

Research Themes

Books

Papers

• 　Activation of epidermal growth factor receptor signaling by the prostaglandin E2 receptor EP4 pathway during gastric tumorigenesis. 　Oshima H, Popivanova BK, Oguma K, Kong D, Ishikawa T, and Oshima M. 　Cancer Science　2011/04
• 　Platelet 12-lipoxigenase accelerates tumor promotion of mouse epidermal cells through enhancement of cloning efficiency.　Piao Y, Du Y, Oshima H, Jin J, Nomura M, Yoshimoto T, Oshima M　2008
• 　Activated macrophages promote Wnt signaling through tumor necrosis factor-alpha in gastric tumor cell.　Oguma K, Oshima H, Aoki M, Uchio R, Naka K, Nakamura S, Hirao A, Saya H, Taketo MM, Oshima M　2008
• 　Induction and downregulation of Sox17 and its possible roles during the course of gastrointestinal tumorigenesis　Du YC, Oshima H, Oguma K, Kitamura T, Itadani H, Fujimura T, Piao YS, Yoshimoto T, Minamoto T, Taketo MM, Oshima M.　GASTROENTEROLOGY　2009/09
• 　Induction of prostaglandin E2 pathway promotes gastric hamartoma development with suppression of bone morphogenetic protein signaling　Oshima H, Itadani H, Kotani H, Taketo MM, Oshima M.　CANCER RESEARCH　69　7　2729-2733　2009/04

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Conference Presentations

Others

• 　Increased levels of serum vascular endothelial growth factor by long-term exposure to hypergravity.　Oshima M, Suzuki H, Guo X, Oshima H　56　4　309-313　2007
• 　Suppression of intestinal polyposis in Apcd716 knockout mice by inhibition of cyclooxygenase 2 (COX-2).　Oshima, M., Dinchuk, J. E., Kargman, S. L., Oshima, H., Hancock, B., Kwong, E., Trzaskos, J. M., Evans, J. F., and Taketo. M. M.　1996
• 　Morphological and molecular processes of polyp formation in Apcd716 knockout mice.　Oshima, H., Oshima, M., Kobayashi, M., Tsutsumi, M., and Taketo, M. M.　1997
• 　Hepatocarcinogenesis in mice with beta-catenin and Ha-ras gene mutstions.　Harada, N., Oshima, H., Katoh, M., Tamai, Y., Oshima, M., and Taketo, M. M.　2004
• 　Hyperplastic gastric tumors induced by activated macrophages in COX-2/mPGES-1 transgenic mice.　Oshima, H., Oshima, M., Inaba, K., and Taketo, M. M.　2004

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Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「上皮細胞腫瘍化と炎症反応の相互作用による消化管発癌機序」(2011-2014)　
○「SOX17の発現変化によるWnt活性制御が消化管腫瘍悪性化に及ぼす影響」(2010-2011)　
○「消化器腫瘍発生におけるCXCL14および組織マクロファージの役割」(2007-)　
○「炎症反応に起因した胃粘膜上皮細胞の腫瘍性増殖機序の研究」(2005-)

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

Classes (Graduate Schools)

○Molecular Genetics of Tumor Biology(2017)
○Molecular Genetics of Tumor Biology(2017)
○Seminar on Tumor Biology(2016)
○Molecular Genetics of Tumor Biology(2016)
○Molecular Genetics of Tumor Biology(2016)