Associate Professor KUNO Koji
Faculty, Affiliation
Cancer Research Institute
College and School Educational Field
Division of Pharmacy, Graduate School of Medical Science
Laboratory
Cancer Research Institute TEL:076-264-6775 FAX:
Academic Background
【Academic background(Doctoral/Master's Degree)】
Kanazawa University Doctor Graduate School, Division of Medicine 198909 Completed
Kanazawa University Master Graduate School, Division of Engineering 198503 Completed
【Academic background(Bachelor's Degree)】
Kanazawa University 198303
Career
Kanazawa University(1992/08/01-2002/01/31)
Kanazawa University(2002/02/01-)
Year & Month of Birth
1961/02
Academic Society
Award
Specialities
Molecular biology、Experimental pathology、General medical chemistry
Speciality Keywords
Research Themes
Roles of ADAMTS family genes in organogenesis and organ function
Extracellular matrix metabolism and disorders
Extracellular matrix metabolism and cancer invasion-metastasis
Books
- Handbook of Proteolytic Enzymes (Second Edition) Academic Press 2004
- ADAMTS-1. In Handbook of Proteolytic Enzymes. Third Edition, (eds. Neil D Rawlings and Guy S. Salvesen) 2013
Papers
- ADAMTS-1 cleaves a cartilage proteoglycan, aggrecan. FEBS LETTERS 478 241-245 2000
- ADAMTS-1 is an active metalloproteinase associated at the extracellular matrix. JOURNAL OF BIOLOGICAL CHEMISTRY 274 26 18821-18826 1999/06
- ADAMTS-1 protein anchors at the extracellular matrix through the thrombospondin type I motifs and its spacing region. JOURNAL OF BIOLOGICAL CHEMISTRY 273 22 18821-18826 1998/05
- ADAMTS-1: a metalloproteinasde-disintegrin essential for growth, fertility, and organ morphology and function. Journal of Clinical Investigation 478 10 1345-1352 2000/05
- Moleucular cloning of a gene encoding a new type of metalloproteinase-disintegrin family protein with thrombospondin motifs as an inflammation associated gene. JOURNAL OF BIOLOGICAL CHEMISTRY 1 272 556-562 1997/04
- ADAMTS-1 is involved in normal follicular development, ovulatory process and organization of the medullary vascular network in the ovary. JOURNAL OF MOLECULAR ENDOCRINOLOGY in press 2005
- C. elegans ADAMTS family gene, adt-1 is necessary for morphogenesis of the male tail copulatory organs. JOURNAL OF BIOLOGICAL CHEMISTRY 277 14 12228-12236 2002/04
- The carboxyl-terminal half region of ADAMTS-1 suppresses both tumorigenicity and experimental metastatic potential. BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 319 1327-1333 2004
- ADAMTS1 alters blood vessel morphology and TSP levels in LNCaP and LNCaP-19 prostate tumors Gustavsson H., Tesan T., Jennbacken K., Kuno K., Damber J.E., Welen K. BMC Cancer 10 288 2010/08
- The exon-intron organization and chromosomal mapping of the mouse ADAMTS-1 gene encoding an ADAM family protein with TSP motifs. GENOMICS 46 466-471 1997
- A disintegrin and metalloproteinase with thrombospondin motifs (ADAMTS)-1 null mutant mice develop renal lesions mimicking obstructive nephropathy. NEPHROLOGY DIALYSIS TRANSPLANTATION 17 suppl 9 39-41 2002
- Class II PI3K alpha and beta are required for Rho-dependent uterine smooth muscle contraction and parturition in mice Sarker M.A.K., Aki S., Yoshioka K., Kuno K., Okamoto Y., Ishimaru K., Takuwa N., Takuwa Y. Endocrinology 160 1 235-248 2019
Conference Presentations
Others
Arts and Fieldwork
Patent
Theme to the desired joint research
Grant-in-Aid for Scientific Research
○「炎症時に発現される新しいADAMファミリー遺伝子ADAMTS-1の機能発現解析」(1997-)
○「炎症時に発現されるＡＤＡＭＴＳＩ遺伝子のトランスジェニックマウスの作製と解析」(1998-)
○「線虫Ｃ・elegansのＡＤＡＭＴＳ－１ホモログ遺伝子の破壊とその変異体の解析」(1999-)
○「ＴＳＰモチーフを有するＡＤＡＭファミリー分子、ＡＤＡＭＴＳ－１の機能解析」(1999-)
○「炎症時に発現されるADAMTS-1プロテアーゼに関する基質の検索」(1999-)
○「TSPモチーフを有するADAMファミリー分子、ADAMTS-1の機能解析」(2000-)
○「TSPモチーフを有するADAMファミリー分子、ADAMTS-1の機能解析」(2000-)
○「TSPモチーフを有するADAMファミリー分子、ADAMTS-1の機能解析」(2001-)
○「ノックアウトマウスを用いたADAMTS-1の骨代謝における役割の解析」(2002-)
○「ノックアウトマウスを用いたADAMTS-1の卵巣機能における役割の解析」(2004-)
○「ノックアウトマウスを用いたADAMTS-1の皮膚損傷治癒過程における役割の解析」(2006-)
Competitive research funding,Contribution
Collaborative research,Consignment study
Classes (Bachelors)
Classes (Graduate Schools)
○Seminar on Tumor Biology(2016)