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Researcher Information

last modified：2024/11/24

Associate Professor　KOBAYASHI Akira

Mail

Faculty, Affiliation

University Hospital　Department of ophthalmology

College and School Educational Field

Division of Medicine, Graduate School of Medical Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences

Laboratory

　TEL:076-265-2403　FAX:076-222-9660

Academic Background

【Academic background(Bachelor's Degree)】
Shiga University of Medical Science　1992
【Degree】
PhD

Career

Year & Month of Birth

Academic Society

American Academy of Ophthalmology


Japan Corneal Society
Japanese Ophthalmological Society
Japanese Society of Ophthalmology
Japanse Society of corneal transplatation
Japanese Society of Ophthalmic Surgery

Award

○Japan Ophthalomology Society Investigator Award(2007)
○Japan Cornea Society Promising Investigator Award(2008)
○Japan Cornea Society Promising Investigator Award(2008)
○Japan Cornea Society Promising Investigator Award(2008)
○Japan Cornea Society Promising Investigator Award(2008)
○Japan Cornea Society Promising Investigator Award(2008)
○Japan Cornea Society Promising Investigator Award(2008)

Specialities

Ophthalmology

Speciality Keywords

anterior segment optical coherence tomography,in vivo confocal microscopy of cornea,endothelial keratoplasty,keratoplasty,amniotic membrane transplantation

Research Themes

Basics and clinical practice of amnion transplant

development of corneal endothelial keratoplasty

in vivo confocal microscopic analysis of corneal disease

Books

  • 　Amniotic membrane transplantation in acute phase of toxic epudermal necrolysis with severe corneal involvement　American Academy of Ophthalmology　113　1　126-132　2006/01
  • 　Akira Kobayashi , Mami Takahashi M, Kazuhisa Sugiyama　Reliability of intraocular pressure by Tono-Pen XL over amniotic membrane patch in human.　13　 413-416　2004
  • 　Akira Kobayashi　Amniotic membrane grafting for a conjunctival defect caused by multiple surgeries　36　 47-49　2004

Papers

  • 　In vivo histology and p.L132V mutation in KRT12 gene in Japanese patients with Meesmann corneal dystrophy.　Nishino T, Kobayashi A, Mori N, Masaki T, Yokogawa H, Fujiki K, Yanagawa A, Murakami A, Sugiyama K　Japanese journal of ophthalmology　63　1　46-55　2019
  • 　Analysis of COL8A2 gene mutation in Japanese patients with Fuchs endothelial dystrophy and posterior polymorphous dystrophy.　JAPANESE JOURNAL OF OPHTHALMOLOGY　48　3　195-198　2004/05
  • 　A 10-year review of underlying diseases for endothelial keratoplasty (DSAEK/DMEK) in a tertiary referral hospital in Japan.　Nishino T, Kobayashi A, Yokogawa H, Mori N, Masaki T, Sugiyama K　Clinical ophthalmology　12　1359-1365　2018
  • 　White-light and laser confocal microscopic findings of rabbit　OPHTHALMIC SURGERY AND LASERS　35　2　146-148　2004/03
  • 　Spontaneous reattachment of dislocated endothelial graft after non-Descemet stripping automated endothelial keratoplasty: a case report.　Kodama-Takahashi A, Fukuda M, Sugioka K, Kobayashi A, Shimomura Y　 BMC ophthalmology 　18　1　14　2018

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  • 　 Indocyanine green staining for the triple corneal procedure.　OPHTHALMIC SURGERY AND LASERS　35　1　23-25　2004/01
  • 　In vivo confocal microscopy and genotyping of a family with Thiel-Behnke (honeycomb) corneal dystrophy.　ARCHIVES OF OPHTHALMOLOGY　121　10　1498-1499　2003/10
  • 　Clinical evaluation of a novel surgical technique (large cross incision) for conjunctival cysts.　Nishino T, Kobayashi A, Mori N, Masaki T, Yokogawa H, Sugiyama K　Canadian journal of ophthalmology.　53　1　e36-e39 　2018
  • 　Double-Bubble Technique in Descemet Membrane Endothelial Keratoplasty for Vitrectomized Eyes: A Case Series.　Hayashi T, Kobayashi A　Cornea　37　9　1185-1188　2018
  • 　Combined Keratoplasty, Pars Plana Vitrectomy, and Flanged Intrascleral Intraocular Lens Fixation to Restore Vision in Complex Eyes With Coexisting Anterior and Posterior Segment Problems.　Yokogawa H, Kobayashi A, Okuda T, Mori N, Masaki T, Sugiyama K　Cornea　37　1　78-85　2018
  • 　Idiopathic limbal squamous metaplasia.　ARCHIVES OF OPHTHALMOLOGY　121　10　1473-1475　2003/10
  • 　Development of a Donor Tissue Holding Technique for Descemet's Membrane Endothelial Keratoplasty Using a 25-Gauge Graft Manipulator.　Kobayashi A, Yokogawa H, Mori N, Masaki T, Sugiyama K　Case reports in ophthalmology　9　3　431-738　2018
  • 　Clinical significance of owl eye morphologic features by in vivo laser confocal microscopy in patients with cytomegalovirus corneal endotheliitis　Kobayashi, Akira; Yokogawa, Hideaki; Higashide, Tomomi; Nitta, Koji; Sugiyama, Kazuhisa　American Journal of Ophthalmology　153　3　445-453　2012/03/01　
  • 　A case of bilateral descemet's membrane and subepithelial opacity: In vivo laser confocal microscopic study　Hatta, Yukiko; Yokogawa, Hideaki; Kobayashi, Akira; Torisaki, Makoto; Sugiyama, Kazuhisa　Case Reports in Ophthalmology　4　1　46-52　2013/01/01　
  • 　Evaluation of Internationally Shipped Prestripped Donor Tissue for Descemet Membrane Endothelial Keratoplasty by Vital Dye Staining　Kobayashi, Akira; Murata, Noriaki; Yokogawa, Hideaki; Yamazaki, Natsuko; Masaki, Toshinori; Sugiyama, Kazuhisa　Cornea　2014/12/17　
  • 　Endothelial keratoplasty with infant donor tissue　Kobayashi, Akira; Yokogawa, Hideaki; Yamazaki, Natsuko; Masaki, Toshinori; Sugiyama, Kazuhisa　Clinical Ophthalmology　8　1827-1830　2014/09/11　
  • 　Descemet's stripping and non-Descemet's stripping automated endothelial keratoplasty for microcornea using 6.0 mm donor grafts　Yokogawa, Hideaki; Kobayashi, Akira; Yamazaki, Natsuko; Ueta, Yoshiki; Hashimoto, Yoshihiro; Tachi, Naoko; Sugiyama, Kazuhisa　Clinical Ophthalmology　7　1951-1956　2013/09/27　
  • 　Ex vivo laser confocal microscopy findings of cultured Acanthamoeba trophozoites　Yamazaki, Natsuko; Kobayashi, Akira; Yokogawa, Hideaki; Ishibashi, Yasuhisa; Oikawa, Yosaburo; Tokoro, Masaharu; Sugiyama, Kazuhisa　Clinical Ophthalmology　6　1　1365-1368　2012/08/21　
  • 　Genetic characterization of clinical Acanthamoeba isolates from Japan using nuclear and mitochondrial small subunit ribosomal RNA　Rahman, Md Moshiur; Yagita, Kenji; Kobayashi, Akira; Oikawa, Yosaburo; Hussein, Amjad I A; Matsumura, Takahiro; Tokoro, Masaharu　Korean Journal of Parasitology　51　4　401-411　2013/08/01　
  • 　Descemet stripping automated endothelial keratoplasty for microcornea　Toshida, Hiroshi; Ohta, Toshihiko; Murakami, Akira; Kobayashi, Akira; Sugiyama, Kazuhisa　Japanese Journal of Ophthalmology　56　5　436-440　2012/09/01　
  • 　Bowman's layer encystment in cases of persistent Acanthamoeba keratitis　Yokogawa, Hideaki; Kobayashi, Akira; Yamazaki, Natsuko; Ishibashi, Yasuhisa; Oikawa, Yosaburo; Tokoro, Masaharu; Sugiyama, Kazuhisa　Clinical Ophthalmology　6　1　1245-1251　2012/08/01　
  • 　A sliding technique to load thin endothelial donor lamella onto Busin glide for Descemet-stripping automated endothelial keratoplasty　Kobayashi, Akira; Yokogawa, Hideaki; Sugiyama, Kazuhisa　Clinical Ophthalmology　6　1　1229-1231　2012/07/31　
  • 　Clinical evaluation of a new donor graft inserter for Descemet's stripping automated endothelial keratoplasty　Yokogawa, Hideaki; Kobayashi, Akira; Sugiyama, Kazuhisa　Ophthalmic Surgery Lasers and Imaging　43　1　50-56　2012/01/01　
  • 　Clinical results of the Neusidl Corneal Inserter? a new donor inserter for Descemet's stripping automated endothelial keratoplasty, for small Asian eyes　Kobayashi, Akira; Yokogawa, Hideaki; Sugiyama, Kazuhisa　Ophthalmic Surgery Lasers and Imaging　43　4　311-318　2012/07/01　
  • 　Clinical features of single and repeated globe rupture after penetrating keratoplasty　Murata, Noriaki; Yokogawa, Hideaki; Kobayashi, Akira; Yamazaki, Natsuko; Sugiyama, Kazuhisa　Clinical Ophthalmology　7　461-465　2013/03/04　
  • 　Clinical evaluation of non-Descemet stripping automated endothelial keratoplasty (nDSAEK)　Masaki, Toshinori; Kobayashi, Akira; Yokogawa, Hideaki; Saito, Yoshiaki; Sugiyama, Kazuhisa　Japanese Journal of Ophthalmology　56　3　203-207　2012/05/01　
  • 　Intraocular Pressure After Descemet's Stripping and Non-Descemet's Stripping Automated Endothelial Keratoplasty　Mawatari, Yoshiro;Kobayashi, Akira;Yokogawa, Hideaki;Sugiyama, Kazuhisa　JAPANESE JOURNAL OF OPHTHALMOLOGY　55　2　98-102　2011
  • 　Evaluation of Internationally Shipped Prestripped Donor Tissue for Descemet Membrane Endothelial Keratoplasty by Vital Dye Staining　Kobayashi, Akira;Murata, Noriaki;Yokogawa, Hideaki;Yamazaki, Natsuko;Masaki, Toshinori;Sugiyama, Kazuhisa　CORNEA　34　2　225-227　2015/01/01　
  • 　The use of endoillumination probe-assisted descemet membrane endothelial keratoplasty for bullous keratopathy secondary to argon laser iridotomy　Kobayashi, Akira; Yokogawa, Hideaki; Yamazaki, Natsuko; Masaki, Toshinori; Sugiyama, Kazuhisa　Clinical Ophthalmology　9　91-93　2015/01/08　
  • 　Surgical therapies for corneal perforations: 10 years of cases in a tertiary referral hospital　Yokogawa, Hideaki; Kobayashi, Akira; Yamazaki, Natsuko; Masaki, Toshinori; Sugiyama, Kazuhisa　Clinical Ophthalmology　8　2165-2170　2014/10/29　
  • 　In Vivo Imaging of Coin-Shaped Lesions in Cytomegalovirus Corneal Endotheliitis by Anterior Segment Optical Coherence Tomography　Yokogawa, Hideaki; Kobayashi, Akira; Yamazaki, Natsuko; Sugiyama, Kazuhisa　Cornea　2014/10/02　
  • 　In vivo laser confocal microscopy findings of a cornea with osteogenesis imperfecta　Kobayashi, Akira; Higashide, Tomomi; Yokogawa, Hideaki; Yamazaki, Natsuko; Masaki, Toshinori; Sugiyama, Kazuhisa　Clinical Ophthalmology　8　429-433　2014/02/21　
  • 　Multicenter study of descemet membrane endothelial keratoplasty: First case series of 18 surgeons　Monnereau, Claire; Quilendrino, Ruth; Dapena, Isabel; Liarakos, Vasilios S.; Alfonso, Jose F.; Arnalich-Montiel, Francisco; B?hnke, Matthias; Pereira, Nicolas Ces?rio; Dirisamer, Martin B.; Parker, John S.; Droutsas, Konstantinos D.; Geerling, Gerd; Gerten, Georg J.; Hashemi, Hassan; Kobayashi, Akira; Naveiras, Miguel; Oganesyan, Oganes; Domingo, Emeterio Ordu?a; Priglinger, Siegfried Georg; Stod?lka, Pavel; Silva, Jos? Torrano; Venzano, Davide; Vetter, Jan Markus; Yiu, Evan; Melles, Gerrit R J　JAMA Ophthalmology　132　10　1192-1198　2014/01/01　
  • 　In vivo imaging of radial keratoneuritis in patients with acanthamoeba keratitis by anterior-segment optical coherence tomography　Yamazaki, Natsuko; Kobayashi, Akira; Yokogawa, Hideaki; Ishibashi, Yasuhisa; Oikawa, Yosaburo; Tokoro, Masaharu; Sugiyama, Kazuhisa　Ophthalmology　121　11　2153-2158　2014/01/01　
  • 　In vivo laser confocal microscopy findings of radial keratoneuritis in patients with early stage acanthamoeba keratitis　Kobayashi, Akira; Yokogawa, Hideaki; Yamazaki, Natsuko; Ishibashi, Yasuhisa; Oikawa, Yosaburo; Tokoro, Masaharu; Sugiyama, Kazuhisa　Ophthalmology　120　7　1348-1353　2013/07/01　
  • 　Rationale for performing penetrating keratoplasty rather than DSAEK in patients with bullous keratopathy in Japan　Yokogawa, Hideaki; Kobayashi, Akira; Saito, Yoshiaki; Yamazaki, Natsuko; Masaki, Toshinori; Sugiyama, Kazuhisa　Ophthalmic Surgery Lasers and Imaging　43　6　446-451　2012/11/01　
  • 　In vivo laser confocal microscopy after descemet's membrane endothelial keratoplasty　Kobayashi, Akira; Yokogawa, Hideaki; Yamazaki, Natsuko; Masaki, Toshinori; Sugiyama, Kazuhisa　Ophthalmology　120　5　923-930　2013/05/01　
  • 　Identification of cytomegalovirus and human herpesvirus-6 DNA in a patient with corneal endotheliitis　Yokogawa, Hideaki; Kobayashi, Akira; Yamazaki, Natsuko; Sugiyama, Kazuhisa　Japanese Journal of Ophthalmology　57　2　185-190　2013/03/01　
  • 　Mapping owl's eye cells of patients with cytomegalovirus corneal endotheliitis using in vivo laser confocal microscopy　Yokogawa, Hideaki; Kobayashi, Akira; Sugiyama, Kazuhisa　Japanese Journal of Ophthalmology　57　1　80-84　2013/01/01　
  • 　In vivo confocal microscopy and ultrasound biomicroscopy study of filtering blebs after trabeculectomy: Limbus-based versus fornix-based conjunctival flaps　Morita, Koji; Gao, Yanlin; Saito, Yoshiaki; Higashide, Tomomi; Kobayashi, Akira; Ohkubo, Shinji; Sugiyama, Kazuhisa　Journal of Glaucoma　21　6　383-391　2012/08/01　
  • 　In vivo laser confocal microscopy findings in patients with map-dot-fingerprint (epithelial basement membrane) dystrophy　Kobayashi, Akira; Yokogawa, Hideaki; Sugiyama, Kazuhisa　Clinical Ophthalmology　6　1　1187-1190　2012/07/26　
  • 　No-touch technique and a new donor adjuster for descemet's stripping automated endothelial keratoplasty　Kobayashi, Akira; Yokogawa, Hideaki; Sugiyama, Kazuhisa　Case Reports in Ophthalmology　3　2　214-220　2012/05/01　
  • 　Management of a small paracentral corneal perforation using iatrogenic iris incarceration and tissue adhesive　Kobayashi, Akira; Yokogawa, Hideaki; Sugiyama, Kazuhisa　Case Reports in Ophthalmology　3　2　226-229　2012/05/01　
  • 　Mathematical projection model of visual loss due to fuchs corneal dystrophy　Hatou, Shin; Shimmura, Shigeto; Shimazaki, Jun; Usui, Tomohiko; Amano, Shiro; Yokogawa, Hideaki; Kobayashi, Akira; Zheng, Xiaodong; Shiraishi, Atsushi; Ohashi, Yuichi; Inatomi, Tsutomu; Tsubota, Kazuo　Investigative Ophthalmology and Visual Science　52　11　7888-7893　2011/10/01　
  • 　In Vivo Laser Confocal Microscopy Findings of Thygeson Superficial Punctate Keratitis　Kobayashi, Akira;Yokogawa, Hideaki;Sugiyama, Kazuhisa　CORNEA　30　6　675-680　2011
  • 　In vivo laser confocal microscopy after Descemet's membrane endothelial keratoplasty.　120　5　923-30
  • 　In vivo laser confocal microscopy findings of radial keratoneuritis in patients with early stage acanthamoeba keratitis　120　7　1348-53　2013/07
  • 　Visualization of precut DSAEK and pre-stripped DMEK donor corneas by intraoperative optical coherence tomography using the RESCAN 700　Kobayashi A, Yokogawa H, Mori N, Sugiyama K　BMC Ophthalmology　2016
  • 　Association of fluorescein anterior corneal mosaic and corneal K-structures by in vivo laser confocal microscopy in patients with keratoconus. 　Kobayashi A, Yokogawa H, Mori N, Masaki T, Sugiyama K 　Clinical ophthalmology　11　1359-1363　2017
  • 　Rebamipide protects against glaucoma eyedrop-induced ocular surface disorders in rabbits.　Kawaguchi I, Kobayashi A, Higashide T, Takeji Y, Sakurai K, Kawaguchi C, Sugiyama K　PloS one　12　10　e0186714 　2017
  • 　Surgery-induced iris abnormalities after Descemet membrane endothelial keratoplasty and their impact on postoperative clinical outcomes. 　Mori N, Yokogawa H, Kobayashi A, Nishino T, Sugiyama K　Clinical ophthalmology　2019

Conference Presentations

Others

  • 　In vivo laser and white-light confocal microscopic findings of human conjunctiva.　35　 482-484　2004
  • 　In vivo confocal microscopy in the patients with central cloudy dystrophy of Francois.　122　1676-1679　2004
  • 　Oxygen permeability of amniotic membrane and actual tear oxygen tension beneath amniotic membrane patch.　138　486-487　2004
  • 　In vivo confocal microscopic findings of Palisade of Vogt and its underlying limbal stroma　24　435-437　2005
  • 　Dtection of corneal epithelial defect through amniotic membrane patch by fluorescein.　24　359-360　2005

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  • 　Visualization of conjunctival cyst using trypan blue and healon V　24　759-760　2005
  • 　In vivo confocal microscopy in a patient with keratopigmentation (corneal tatooing)　24　238-240　2005
  • 　In vivo findings of bulbar/palpebral conjunctiva and presumed meibomian gland by laser scanning confocal microscopy.　24:985-988　2005
  • 　Endogenous endophthalmitis caused by Enterococcus mundtii　43:1475-1476　2005
  • 　Disappearance of honeycomb opacity of Thiel-Behnke corneal dystrophy after Thygeson's superficial punctuate keratitis.　24　1029-1030　2005
  • 　In vivo laser confocal microscopic analysis of human corneal epithelial sheet cultured on amniotic membrane.　7:304-309　2006
  • 　Bilateral corneal perforation in an infant with congenital alacrima.　43　236-238　2006
  • 　Intraocular pressure by noncontact tonometry over an amniotic membrane patch in humans.　141　508-511　2006
  • 　The influence of clinical factors on Blue-on-Yellow perimetry in diabetic patients without retinopathy -comparison with White-on-white perimetry　26;792-802　2006
  • 　Truncation mutation in HRG4 (UNC119) leads to mitochondrial ANT-1-mediated degeneration in photoreceptor synapses and retinal degeneration by apoptosis.　47　1281-92　2006
  • 　Measurement of light transmittance of cryopreserved human amniotic membrane　25　1080-1083　2006
  • 　In vivo laser confocal microscopy of Bowman's layer of the cornea　113　2203-2208　2006
  • 　In vivo laser confocal microscopy findings for Bowman's layer dystrophies(Thiel-Behnke and Reis-Bucklers corneal dystrophies)　114　69-75　2007
  • 　Successful removal of a large conjunctival cyst using colored Healon V　38　81-83　2007
  • 　Measurement of light transmission of human limbal epithelial cells cultured on human amniotic membranes　25　1080-1083　2007
  • 　Postoperative retinal break after 25-gauge transconjunctival sutureless vitrectomy-report of four cases-　245　155-157　2007
  • 　Targeted inactivation of synaptic HRG4 (UNC119) causes dysfunction in the distal photoreceptor and slow retinal degeneration, revealing a new function　84　473-485　2007
  • 　In vivo laser confocal microscopy findings of corneal stromal dystrophies　125　1168-1173　2007
  • 　Evaluation of visual acuity and color vision in normal human eyes with a sutureless temporary amniotic membrane patch　144　938-942　2007
  • 　In vivo laser confocal microscopic analysis of murine cornea and lens microstructures　39　391-6　2008
  • 　Descemet stripping with automated endothelial keratoplasty for bullous keratopathies secondary to argon laser iridotomy--preliminary results and usefulness of double-glide donor insertion technique　27 Suppl 1:S62-9　2007
  • 　A flexible chandelier fiber probe holder for vitrectomy　28　1170　2008
  • 　Mapping of normal corneal K-structures by in vivo laser confocal microscopy　27:879-83　2008
  • 　In vivo laser confocal microscopy findings of cryopreserved and fresh human amniotic membrane　39:312-8　2008
  • 　Non-Descemet stripping automated endothelial keratoplasty for endothelial dysfunction secondary to argon laser iridotomy　146:543-549　2008
  • 　A new self-sealing cannula system for 20-gauge vitrectomy, outcomes of 247 consecutive cases　28　778-81　2008
  • 　In vivo and ex vivo laser confocal microscopy findings in patients with early-stage acanthamoeba keratitis　27:439-45　2008
  • 　In vivo laser confocal microscopy after descemet stripping with automated endothelial keratoplasty　145　977-985　2008

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「水疱性角膜症に対する新しい角膜内皮移植術（DMEK）の確立と、術後視機能の解析」(2013-2015)　
○「水疱性角膜症に対する新しい角膜内皮移植術(nDSAEK)の開発と包括的視機能解析」(2010-2011)　
○「角膜，結膜，眼瞼におけるアポトーシス関連遺伝子の局在解明」(1999-)　
○「角膜、結膜幹細胞の神経調節機構の解明」(2001-)　
○「生体コンタクトレンズとしてのヒト羊膜の物理化学的性状の解析」(2004-)　
○「ヒト角膜における新しい構造物（K-structure）の発見と臨床的意義の探求」(2007-)　
○「新しい角膜内皮移植（DMEK/DMAEK/PDEK）の確立とドナー接着機構の解明」(2016-2018)　
○「水疱性角膜症に対する新しい角膜内皮移植術（DMEK）の確立と、術後視機能の解析　」(2013-2015)

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

○ophthalmology(2022)
○ophthalmology(2018)
○ophthalmology(2017)
○ophthalmology(2016)

Classes (Graduate Schools)

○Visual Science(2018)
○Visual Science(2017)
○Visual Science(2017)
○Visual Science(2017)
○Visual Science(2016)
○Visual Science(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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