Associate Professor SUGITANI Kayo
Faculty, Affiliation
Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences
College and School Educational Field
Division of Health Sciences, Graduate School of Medical Science
Division of Health Sciences，Graduate School of Medical Science
Department of Laboratory Sciences，School of Health Sciences, College of Medical, Pharmaceutical and Health Sciences
Laboratory
Div Health Sci, Grad Sch Med Sci, Kanazawa Univ, Kanazawa, Japan TEL:076-265-2599 FAX:076-234-4369
Academic Background
【Degree】
Doctor of medicine
Career
Year & Month of Birth
Academic Society
THE PHYSIOLOGICAL SOCIETY OF JAPAN
Society for Neuroscience
Award
Specialities
Biomolecular chemistry、Neurochemistry/Neuropharmacology、Pathological medical chemistry
Speciality Keywords
Factor XIII-A, CNS regeneration, transglutaminase, Acute phase response molecule, antibacterial activity
Research Themes
Study of CNS regeneration
Mammalian central nerves, once injured, become irreversibly damaged and the damage leads to functional loss. In contrast, neuraxon regeneration is possible with the central nerves of fish. For example, when optic nerves are severed in goldfish, neurites re-elongate at the severed end in about a week, regenerated neuraxons reach the arget optic tecta in about a month, and subsequently, after synaptic reorganization, optic functions themselves are fully recovered in 5-6 months. Characteristically in fish, neuron deaths are suppressed first to maintain life after neuraxon injury, and then manifestation of molecules is induced to newly elongate neurites. By explaining this regeneration mechanism, I explore the possibility of central neuraxon regeneration in mammals.
Activation of Factor XIII-A as an acute phase reactant in wound healing mechanism
Clinical microbiology, Measurementof antibacterial activity
Books
- infection of the digestive tract 2008/09
- Kato, S., Koriyama, Y., Matsukawa, T., Sugitani, K. Optic nerve regeneration in goldfish. Wiley-VCH 352-372 2007/01
- Sugitani, K., Matsukawa, T., Maeda, A., Kato, S Upregulation of transglutaminase in the goldfish retina during optic nerve regeneration. Springer US 2006/01
- Devadas, M. , Sugitani, K. et , Kato, S. et al. A Multidisciplinary Approach to Investigating Optic Nerve Regeneration in the Goldfish. Kluwer Academic/Plenum Publishers 2001/12
- Matsukawa, T., Zhou, Z. Y., Sugawara, K. , Devadas, M., Takizawa, N., Sugitani, K., Kato S. An Uncoupling Effect of Reactive Oxygen Species on the Retinal Horizontal Cells Springer 361-369 1999/01
- Kato S., Zhou, Z. Y., Sugawara, K., Yasui, N., Takizawa, N., Sugitani, K., Mawatari, K. Ischemic neuronal death in the fish retina: In respect of oxygen radicals and glutathione. Springer-Verlag New York, LLC 199-204 1997/11
Papers
- Specific Activation of Yamanaka Factors via HSF1 Signaling in the Early Stage of Zebrafish Optic Nerve Regeneration Kayo Sugitani; Takumi Mokuya; Shuichi Homma; Minami Maeda; Ayano Konno; Kazuhiro Ogai Int. J. Mol. Sci. 24 4 3253 2023/02/07
- A novel activation mechanism of cellular Factor XIII in zebrafish retina after optic nerve injury. Sugitani K, Ogai K, Muto H, Onodera K, Matsuoka A, Sugita T, Koriyama Y. Biochem Biophys Res Commun. 517 1 57-62 2019/09/10
- A Comparison of Techniques for Collecting Skin Microbiome Samples: Swabbing Versus Tape-Stripping. Front Microbiol. 2018/10/02
- RANKL, Ephrin-Eph and Wnt10b are key intercellular communication molecules regulating bone remodeling in autologous transplanted goldfish scales. Tazaki Y, Sugitani K, Ogai K, Kobayashi I, Kawasaki H, Aoyama T, Suzuki N, Tabuchi Y, Hattori A, Kitamura KI. Comp Biochem Physiol 225 46-58 2018/06/15
- Alternative Splicing for Activation of Coagulation Factor XIII-A in the Fish Retina After Optic Nerve Injury. Sugitani K, Koriyama Y, Ogai K, Furukawa A, Kato S. Adv Exp Med Biol. 1074 387-393 2018/05/03
- Talaumidin Promotes Neurite Outgrowth of Staurosporine-Differentiated RGC-5 Cells Through PI3K/Akt-Dependent Pathways. Koriyama Y, Furukawa A, Sugitani K, Kubo M, Harada K, Fukuyama Y. Adv Exp Med Biol. 1074 649-653 2018/05/03
- Protein Carbonylation-Dependent Photoreceptor Cell Death Induced by N-Methyl-N-nitrosourea in Mice. Furukawa A, Sugitani K, Koriyama Y. Adv Exp Med Biol. 1074 297-302 2018/05/03
- A novel function of neuroglobin for neuroregeneration in mice after optic nerve injury. Sugitani K, Koriyama Y, Sera M, Arai K, Ogai K, Wakasugi K. Biochem Biophys Res Commun. 493 3 1254-1259 2017/09/23
- Effects of hyperglycemia on bone metabolism and bone matrix in goldfish scales. Kitamura KI, Andoh T, Okesaku W, Tazaki Y, Ogai K, Sugitani K, Kobayashi I, Suzuki N, Chen W, Ikegame M, Hattori A. Comp Biochem Physiol A Mol Integr Physiol. 203 152-158 2017/01/01
- Anti-Inflammatory and Antioxidant Effects of Repeated Exposure to Cruciferous Allyl Nitrile in Sensitizer-Induced Ear Edema in Mice. Tanii H, Sugitani K, Saijoh K. Med Sci Monit Basic Res. 22 20-26 2016/02/29
- Involvement of neuronal nitric oxide synthase in N-methyl-N-nitrosourea-induced retinal degeneration in mice. Koriyama Y, Hisano S, Ogai K, Sugitani K, Furukawa A, Kato S. J Pharmacol Sci. 127 394-396 2015/02/17
- A Possible Role of Neuroglobin in the Retina After Optic Nerve Injury: A Comparative Study of Zebrafish and Mouse Retina. Sugitani K, Koriyama Y, Ogai K, Wakasugi K, Kato S. Adv Exp Med Biol. 854 671-675 2015/10/02
- Cell Fate of Müller Cells During Photoreceptor Regeneration in an N-Methyl-N-nitrosourea-Induced Retinal Degeneration Model of Zebrafish. Ogai K, Hisano S, Sugitani K, Koriyama Y, Kato S. Adv Exp Med Biol. 854 685-692 2015/10/02
- Nitric Oxide Synthase Activation as a Trigger of N-methyl-N-nitrosourea-Induced Photoreceptor Cell Death. Hisano S, Koriyama Y, Ogai K, Sugitani K, Kato S. Adv Exp Med Biol. 854 379-384 2015/10/02
- Geranylgeranylacetone Suppresses N-Methyl-N-nitrosourea-Induced Photoreceptor Cell Loss in Mice. Koriyama Y, Ogai K, Sugitani K, Hisano S, Kato S. Adv Exp Med Biol. 854 237-243 2015/10/02
- Reciprocal changes in factor XIII and retinal transglutaminase expressions in the fish retina during optic nerve regeneration. Sugitani K, Ogai K, Koriyama Y, Kato S. Adv Exp Med Biol. 801 759-764 2014/03/25
- Nipradilol promotes axon regeneration through S-nitrosylation of PTEN in retinal ganglion cells. Koriyama Y, Kamiya M, Arai K, Sugitani K, Ogai K, Kato S. Adv Exp Med Biol. 801 751-757 2014/03/25
- Regeneration-associated genes on optic nerve regeneration in fish retina. Ogai K, Nishitani M, Kuwana A, Mawatari K, Koriyama Y, Sugitani K, Nakashima H, Kato S. Adv Exp Med Biol. 2014/03/25
- Heat shock protein 70 induction by valproic acid delays photoreceptor cell death by N-methyl-N-nitrosourea in mice. Koriyama Y, Sugitani K, Ogai K, Kato S. JOURNAL OF NEUROCHEMISTRY 2014/05/22
- Function of Sox2 in ependymal cells of lesioned spinal cords in adult zebrafish. Ogai K, Nakatani K, Hisano S, Sugitani K, Koriyama Y, Kato S. Neurosci Res. 88 84-87 2014/08/20
- Upregulation of Leukemia Inhibitory Factor (LIF) during the Early Stage of Optic Nerve Regeneration in Zebrafish. Ogai K, Kuwana A, Hisano S, Nagashima M, Koriyama Y, Sugitani K, Mawatari K, Nakashima H, Kato S. PLoS One. 27 9 e106010 2014/08/27
- Functional characterization of fish neuroglobin: Zebrafish neuroglobin is highly expressed in amacrine cells after optic nerve injury and can translocate into ZF4 cells Kamioka, Yuki;Fujikawa, Chieko;Ogai, Kazuhiro;Sugitani, Kayo;Watanabe, Seiji;Kato, Satoru;Wakasugi, Keisuke Biochim Biophys Acta. 1834 9 1779-1788 2013/02/24
- Anti-inflammatory effects of lipoic acid through inhibition of GSK-3β in lipopolysaccharide-induced BV-2 microglial cells. Koriyama Y, Nakayama Y, Matsugo S, Sugitani K, Ogai K, Takadera T, Kato S. Neurosci Res. 2013/07/24
- Requirement of retinoic acid receptor β for genipin derivative-induced optic nerve regeneration in adult rat retina. Koriyama Y, Takagi Y, Chiba K, Yamazaki M, Sugitani K, Arai K, Suzuki H, Kato S. PLoS One. e71252. 2013/08/06
- A molecular mechanism of optic nerve regeneration in fish: the retinoid signaling pathway. Kato S, Matsukawa T, Koriyama Y, Sugitani K, Ogai K. Prog Retin Eye Res. 37 13-30 2013/08/28
- Neuritogenic activity of trichostatin A in adult rat retinal ganglion cells through acetylation of histone H3 lysine 9 and RARβ induction. Koriyama Y, Sugitani K, Ogai K, Kato S. J Pharmacol Sci. 124 1 112-116 2013/12/27
- A distinct effect of transient and sustained upregulation of cellular factor XIII in the goldfish retina and optic nerve on optic nerve regeneration. Sugitani K, Ogai K, Hitomi K, Nakamura-Yonehara K, Shintani T, Noda M, NEUROCHEMISTRY INTERNATIONAL 61 3 423-432 2012/06/16
- A distinct effect of transient and sustained upregulation of cellular factor XIII in the goldfish retina and optic nerve on optic nerve regeneration Sugitani, Kayo; Ogai, Kazuhiro; Hitomi, Kiyotaka; Nakamura-Yonehara, Kayo; Shintani, Takafumi; Noda, Masaharu; Koriyama, Yoshiki; Tanii, Hideji; Matsukawa, Toru; Kato, Satoru Neurochemistry International 61 3 423-432 2012/08/01
- Upregulation of anti-apoptotic factors in upper motor neurons after spinal cord injury in adult zebrafish. Ogai K, Hisano S, Mawatari K, Sugitani K, Koriyama Y, Nakashima H, Kato S. NEUROCHEMISTRY INTERNATIONAL 61 7 1202-0211 2012/09/08
- Protective action of nipradilol mediated through S-nitrosylation of Keap1 and HO-1 induction in retinal ganglion cells. Koriyama Y, Kamiya M, Takadera T, Arai K, Sugitani K, Ogai K, Kato S. NEUROCHEMISTRY INTERNATIONAL 61 7 1242-1253 2012/09/17
- Neuritogenic activity of a genipin derivative in retinal ganglion cells is mediated by retinoic acid receptor beta expression through nitric oxide/S-nitrosylation signaling. Koriyama Y, Takagi Y, Chiba K, Yamazaki M, Arai K, Matsukawa T, Suzuki H, Sugitani K, Kagechika H, Kato S. JOURNAL OF NEUROCHEMISTRY 119 6 1232-1242. 2011/11/09
- Factor XIIIA induction in the retina and optic nerve after optic nerve lesion in goldfish Sugitani, Kayo; Oogai, Kazuhiro; Nakashima, Hiroshi; Kato, Satoru Adv Exp Med Biol. 723 443-448 2011/11/11
- An application for mammalian optic nerve repair by fish regeneration-associated genes. Koriyama Y, Sugitani K, Matsukawa T, Kato S. Adv Exp Med Biol. 723 161-166 2011/11/11
- Purpurin is a key molecule for cell differentiation during the early development of zebrafish retina. Nagashima M, Mawatari K, Tanaka M, Higashi T, Saito H, Muramoto K, Matsukawa T, Koriyama Y, Sugitani K, Kato S. BRAIN RESEARCH 2009/09/11
- Growth-associated protein43 (GAP43) is a biochemical marker for the whole period of fish optic nerve regeneration. Kaneda M, Nagashima M, Mawatari K, Nunome T, Muramoto K, Sugitani K, Kato S Adv Exp Med Biol. 664 97-104 2009/12/28
- Nitric oxide-cGMP signaling regulates axonal elongation during optic nerve regeneration in the goldfish in vitro and in vivo. Koriyama Y, Yasuda R, Homma K, Mawatari K, Nagashima M, Sugitani K, Matsukawa T, Kato S. JOURNAL OF NEUROCHEMISTRY 110 3 890-901 2009/05/18
- Unconstrained monitoring of long-term heart and breath rates during sleep. Physiological Measurement Chen W, Zhu X, Nemoto T, Kitamura K, Sugitani K, Wei D. PHYSIOLOGICAL MEASUREMENT 29 2 1-10 2008/01/14
- Changes of phospho-growth associated protein 43 (phospho-GAP43) in zebrafish retina after optic nerve injury: a long term observation. Kaneda M, Nagashima M, Nunome T, Muramatsu T, Yamada Y, Kubo M, Muramoto K, Matsukawa T, Koriyama Y, Sugitani K, Vachkov I, Mawatari K, Kato S. NEUROSCIENCE RESEARCH 61 3 281-288 2008/04/08
- Upregulation of IGF-I in the goldfish retinal ganglion cells during the early stage of optic nerve regeneration. Koriyama Y, Homma K, Sugitani K, Higuchi Y, Matsukawa T, Murayama D, Kato S. NEUROCHEMISTRY INTERNATIONAL 50 5 749-756 2007/02/08
- Upregulation of retinal transglutaminase during the axonal elongation stage of goldfish optic nerve regeneration Sugitani K. Matsukawa T. Koriyama Y. Shintani T. Nakamura T. Noda M. Kato S. NEUROSCIENCE 142 4 1081-1092 2006/09/25
- Role of Purpurin as a Retinol-Binding Protein in Goldfish Retina during the Early Stage of Optic Nerve Regeneration: Its Priming Action on Neurite Outgrowth Matsukawa T, Sugitani K, Mawatari K, Koriyama Y, Liu Z, Tanaka M, Kato S. J Neurosci. 24 38 8386-8353 2004/09/22
- A computer image processing system for quantification of zebrafish behavior Kato S, Nakagawa T, Ohkawa M, Muramoto K, Oyama O, Watanabe A, Nakashima H, Nemoto T, Sugitani K. J Neurosci Methods 1 134 1-7 2004/03/15
- The goldfish visual system as a useful model for CNS regeneration: From gene to behaviour Sugitani, K. , Kato, S. Recent Research Developments in Neurochemistry 5 375-383 2002/12
- Slow recovery of goldfish retinal ganglion cells' soma size during regeneration Devadas M, Sugawara K, Shimada Y, Sugitani K, Liu ZW, Matsukawa T, Kato S. Neurosci.Res. 37 4 289-297 2000/08
- Specific Activation of Yamanaka Factors via HSF1 Signaling in the Early Stage of Zebrafish Optic Nerve Regeneration Kayo Sugitani,Takumi Mokuya,Shuichi Homma,Minami Maeda,Ayano Konno,Kazuhiro Ogai International Journal of Molecular Sciences 24 4 3253 2023/02/07
Conference Presentations
- Role of expression of Transglutaminase 2 in the zebrafish retina just after optic nerve injury.(2024/03/29)
- ゼブラフィッシュ視神経修復過程におけるMyeloid-derived growth factorの関与について(2024/03/29)
- Activation mechanism of heat shock factor 1 induced after zebrafish optic nerve injury (2020/03/19)
- Heat Shock Factor 1 is involved in the expression of Yamanaka factors in zebrafish retina after optic nerve injury(2022/03/16)
- Mechanism of neuron specific activation of Factor XIII-A after optic nerve injury for wound healing (2018/09/08)
- Alternative splicing for activation of coagulation factor XIII-A in the fish retina and optic nerve after optic nerve injury(2017/03/28)
- Upregulation of heat shock factor and Factor XIII-A after optic nerve injury in zebrafish(conference：FAOPS2019(The 9th Federation of Asian and Oceanian Physiological Societies Congress))(2019/03/30)
- Mechanism of non-enzymatic activation of Factor XIII-A in zebrafish retina and optic nerve after optic nerve injury
- Comparative study of neuroglobin in mouse and zebrafish retina after optic nerve injury(2013)
- Upregulation of leukemia inhibitory factor (LIF) and Sox2 after optic nerve injury in adult zebrafish(2013/06/21)
- A novel function of Factor XIII on nerve regeneration(conference：第86回日本生化学会大会)(2013/09)
- 第58回日本神経化学会大会(conference：International Workshop on FXIII)(2013/02)
- Upregulation of leukemia inhibitory factor (LIF) and Sox2 after optic nerve injury in adult zebrafish.(2013)
- Neuroglobin as a regeneration associated molecules in zebrafish retina after optic nerve injury.(2013)
- A novel function of Factor XIII-A on nerve regeneration.(2013)
- Upregulation of a regeneration-related molecule on regrowing optic axons in goldfish(2011)
- Reciprocal changes of factor XIII and retinal transglutaminase expressions in the fish retina during optic nerve regeneration.(2012)
- A distinct effect of two types of transglutaminase on fish optic nerve regeneration.(2012)
- Role of the transglutaminase family on optic nerve regeneration in fish.(2011)
- Expression of factor XIIIA in regenerating retina of fish and its effect on neurite outgrowth(2011)
- Factor XIIIA induction in regenerating retina and axons in the fish ocular system(2010)
- Factor XIII expression and its implication in fish optic nerve regeneration(2009)
- Involvement of Factor XIII in fish optic nerve regeneration(2008)
- Regulation of galectins in retina and its possible role in fish optic nerve regeneration(2008)
- Regulation of galectins in fish retina after optic nerve lesion(2007)
- An application study of mammalian optic nerve regeneration using fish nerve regenerating molecules(2007)
- Regeneration of the efferent fibers after fish optic nerve transection(2007)
- Involvement of transglutaminase family in the optic nerve regeneration(2006)
- Role of Retinoids in Goldfish Retina during Optic Nerve Regeneration(2005)
- Regeneration of the efferent fibers of fish optic nerve after transection(2005)
- Upregulation of transglutaminase gene in the goldfish retina during optic nerve regeneration(2004)
- Upregulation of transglutaminase in retina and its possible role in goldfish optic nerve regeneration(2004)
- A promoting action of transglutaminase on regrowing optic axons in goldfish(2004)
- Heat shock protein 70 induction delays photoreceptor cell death by N‐methyl‐Nnitrosourea in mice(conference：XVI International Symposium on Retinal Degeneration RD2014)(2014/07/13)
- Activation of coagulation Factor XIII-A in the retina and optic nerve and its functional roles after optic nerve injury.(conference：XVII INTERNATIONAL SYMPOSIUM ON RETINAL DEGENERATION RD2016)(2016/09/19)
- Protective effect of talaumidin against retinal ganglion cell death through Erk and Akt pathway(conference：XVII INTERNATIONAL SYMPOSIUM ON RETINAL DEGENERATION RD2016)(2016/09/19)
- The functional study of Neuroglobin under oxidative stress in mouse retina(2014/03/16)
- Changes of EGF and HB‐EGF during photoreceptor regeneration in MNU‐induced(conference：XVI International Symposium on Retinal Degeneration RD2014)(2014/07/13)
- A comparative study of Neuroglobin expression in mouse and zebrafish retina after optic nerve injury(conference：XVI International Symposium on Retinal Degeneration RD2014)(2014/07/13)
- nNOS/NO as a trigger of the MNU‐induced photoreceptor cell death(conference：XVI International Symposium on Retinal Degeneration RD2014)(2014/07/13)
Others
- Optic nerve regeneration in goldfish. In: Model organisms in spinal cord regeneration. Kato, S., Koriyama, Y., Matsukawa, T., Sugitani, K. Wiley-VCH. 2007/01
Arts and Fieldwork
Patent
Theme to the desired joint research
Grant-in-Aid for Scientific Research
○2023「HSF-1 が関与する中枢神経再生へのカスケード反応」(2020-2023)
○「急性相反応物質としてのFactor XIII-Aの活性化と創傷治癒機構の作動」(2017-2020)
○「皮膚常在菌叢の変化に着目した褥瘡後感染症の原因解析及びその予防・緩和ケアの検討」(2017-2020)
○「基盤研究（Ｃ）」(2016-2018)
○「神経再生におけるcellular Factor XIII 活性化機構の解明」(2014-2017)
○「脊髄損傷後の感覚神経線維再生促進の新しい試み」(2013-2014)
○「ゼブラフィッシュ視神経再構築におけるFactor XIIIAの関与とその作用機序」(2011-2014)
○「視神経再生分子を用いた損傷網膜神経節細胞の軸索再伸長」(2007-2008)
○「レチノイン酸が成熟金魚の視神経再生を引き起こす
」(2004-2005)
Competitive research funding,Contribution
Collaborative research,Consignment study
○Analysis of antibacterial activity of synthetic fiber product and its visualization(2008-2009)
○Study of antibacterial products(2007-2009)
○Study of fish CNS regeneration system and its application to mammalian CNS neuron.(2007-2007)
Classes (Bachelors)
○Public Health(2021)
○Customized Research Project(2021)
○Practical Course in Laboratory of Serology and Immunology(2020)
○Pathogenic Microbiology 1(2020)
○Clinial Practice of Pathologic Microbiology(2020)
○Laboratory of Serology and Immunology(2020)
○Practice in Pathogenic Microbiology(2020)
○Public Health(2020)
○Customized Research Project(2020)
○Introduction to Information Technology(2020)
○Practice in Pathogenic Microbiology(2019)
○Laboratory of Serology and Immunology(2019)
○Introduction to Information Technology(2019)
○Practical Course in Laboratory of Serology and Immunology(2019)
○Research Project(2019)
○Public Health(2019)
○Clinial Practice of Pathologic Microbiology(2019)
○Practice in Pathogenic Microbiology(2018)
○Laboratory of Serology and Immunology(2018)
○Research Project(2017)
○Lecture on Clinical Laboratory Management(2017)
○Introduction to Information Technology(2017)
○Clinial Practice of Pathologic Microbiology(2017)
○Pathogenic Microbiology 1(2017)
○Introduction to Information Technology(2017)
○Practice in Pathogenic Microbiology(2017)
○Practical Course in Laboratory of Serology and Immunology(2017)
○Clinial Practice of Pathologic Microbiology(2017)
○Introduction to Region-studies(2017)
○Lecture on Clinical Laboratory Management(2017)
○Freshman Seminar I(2017)
○Laboratory of Serology and Immunology(2017)
○Bacterial Toxicology(2017)
○Practical Course in Laboratory of Serology and Immunology(2017)
○Bacterial Toxicology(2017)
○Pathogenic Microbiology 1(2017)
○Research Project(2016)
○Practice in Pathogenic Microbiology(2013)
○Practical Course in Laboratory of Serology and Immunology(2013)
○Clinical Laboratory Management(2013)
○Bacterial Toxicology(2013)
○Pathogenic Microbiology, Practice(2009)
○Practice of Laboratory Immunology(2009)
Classes (Graduate Schools)
○An Introduction to Medical Laboratory Sciences:Lec(2021)
○Infectious/Pathogenic Agents: Lecture(2021)
○Infectious/Pathogenic Agents: Lecture(2021)
○An Introduction to Medical Laboratory Sciences:Lec(2020)
○Infectious/Pathogenic Agents: Lecture(2020)
○Infectious/Pathogenic Agents: Seminar(2020)
○分子生物検査学課題研究(2019)
○Infectious/Pathogenic Agents: Lecture(2019)
○分子生物検査学課題研究(2018)
○An Introduction to Medical Laboratory Sciences:Lec(2018)
○Infectious/Pathogenic Agents: Seminar(2018)
○Infectious/Pathogenic Agents: Lecture(2017)
○An Introduction to Medical Laboratory Sciences:Lec(2017)
○Infectious/Pathogenic Agents: Seminar(2017)
○分子生物検査学課題研究(2016)