- Top Page
- Faculty List by Affiliation
- Profile
last modified：2025/04/15
Associate Professor YOSHIOKA Kazuaki
Faculty, Affiliation
Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences
Associate Professor
College and School Educational Field
Division of Medicine, Graduate School of Medical Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences
Laboratory
Department of Vasucular Molecular Physiology TEL:076-265-2166 FAX:076-234-4223
Academic Background
【Academic background(Doctoral/Master's Degree)】
Tokyo University of Agriculture and Technology Doctor Graduate School, Division of Engineering Molecular Biotechnology 199803 Completed
【Academic background(Bachelor's Degree)】
Tokyo University of Agriculture and Technology Industrial Chemistry 199603
Career
Tokyo Metropolitan Institute for Neuroscience Molecular and Cellular Neurobiology(1999/10/01-2002/04/01)
Bioanalytical Systems, Inc. Microdialysis(1998/04/01-1999/09/30)
Year & Month of Birth
1969/04
Academic Society
Award
○Young Investigator Award(2006/12/01)
○Mitsubishi Pharma Research Foundation(2004)
Specialities
General physiology
Speciality Keywords
PI3 kinase,Autophagy,Endocytosis,Membrane Trafficking,Signal transduction,contruction-relaxation Smooth muscle cell,Cardiovascular remodeling,Angiogenesis
Research Themes
Single-cell RNA-sequence analysis of adventitial vasa vasorum in human aortic dissection.
Study of physiological role of cardiovascular remodeling using knockout mouse.
Regulation of Pulmonary stem cell function through intracellular clearance.
Regulation of contraction of vascular smooth muscle cells by mechanical stimulus
Books
- Role of sphingosine-1-phosphate signaling in atherosclerosis John Wiley & Sons 2011/01
- Sphingosine-1-phosphate regulation of macrophages in atherosclerosis Springer 2011/01
Papers
- Synthesis and structure-activity relationships of selective ligands for P3 purinoceptor-like protein (P3LP) Nucleic Acids Symposium Series 44 19-20 2000
- Effects of melatonin administration on the release of endogenous 5-HT and its metabolite in rat SCN Yoshioka, K., Xie, F., Gitzen, J., Kissinger, C. and Kissinger, P Asian J. Drug Metabolism & Pharmacokinetics 3 265-272 2003/01
- Rho-dependent, Rho kinase-independent inhibitory regulation of Rac and cell migration by LPA1 receptor in Gi-inactivated CHO cells. Sugimoto, N., Takuwa, N., Yoshioka, K. and Takuwa, Y. EXPERIMENTAL CELL RESEARCH 312 1899-1908 2006/01
- Sphingosine-1-phosphate signaling and biological activities in the cardiovascular system. Takuwa Y, Okamoto Y, Yoshioka K, Takuwa N. BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1781 483-488 2008/01
- Roles of sphingosine-1-phosphate signaling in angiogenesis. Y Takuwa, W Du, X Qi, Y Okamoto, N Takuwa, K Yoshioka. World J Biol Chem. 1 10 298-306 2010/01
- Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in Apoe-deficient mice. JOURNAL OF CLINICAL INVESTIGATION 120 3979-3995 2010/01
- S1P(2), the G protein-coupled receptor for sphingosine-1-phosphate, negatively regulates tumor angiogenesis and tumor growth in vivo in mice. Du W, Takuwa N, Yoshioka K, Okamoto Y, Gonda K, Sugihara K, Fukamizu A, Asano M, Takuwa Y. CANCER RESEARCH 70 772-781 2010/01
- Sustained delivery of sphingosine-1-phosphate using poly(lactic-co-glycolic acid)-based microparticles stimulates Akt/ERK-eNOS mediated angiogenesis and vascular maturation restoring blood flow in ischemic limbs of mice. Xun Qi, Yasuo Okamoto, Tomomi Murakawa, Fei Wang, Osamu Oyama, Ryunosuke Ohkawa, Kazuaki Yoshioka, Wa Du, Naotoshi Sugimoto, Yutaka Yatomi, Noriko Takuwa, Yoh Takuwa EUROPEAN JOURNAL OF PHARMACOLOGY 634 121-131 2010/01
- Sphingosine-1-phosphate signaling and cardiac fibrosis. Inflammation & Regeneration 33 2 96-108 2013/01
- Sphingoshine-1-phospahte as a mediator involved in development of fibrotic diseases. BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 1831 185-192 2013/01
- Sphingosine-1-phosphate receptor-2 protects against anaphylactic shock through suppression of eNOS in mice. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 132 5 1205-1214 2013
- Class II PI3 kinase C2 alpha has an essential role in angiogenesis and vascular homeostasis through regulating endosomal trafficking Yoshioka, Kazuaki;Takuwa, Noriko;Okamoto, Yasuo;Takuwa, Yoh JOURNAL OF PHYSIOLOGICAL SCIENCES 63 0 S98-S98 2013
- Class II PI3 kinase-C2 alpha plays essential roles in endosomal Rac1 activation and cell migration in S1P-stimulated endothelial cells Biswas, Kuntal;Yoshioka, Kazuaki;Aki, Sho;Cui Hong;Zhao JuanJuan;Kuda, Yuichi;Takuwa, Noriko;Okamoto, Yasuo;Takuwa, Yoh JOURNAL OF PHYSIOLOGICAL SCIENCES 63 0 S136-S136 2013
- Sphingosine-1-phosphate receptor-2 plays a protective role against anaphylactic shock through inhibiting eNOS Cui Hong;Okamoto, Yasuo;Yoshioka, Kazuaki;Du Wa;Takuwa, Noriko;Zhang Wei;Biswas, Kuntal;Aki, Sho;Zhao JuanJuan;Kuda, Yuichi;Asano, Masahide;Shibamoto, Toshishige;Takuwa, Yoh JOURNAL OF PHYSIOLOGICAL SCIENCES 63 0 S119-S119 2013
- Disruption of sphingosine-1-phosphate receptor-2 gene inhibits atherosclerosis in apoE-deficient mice Wang, Fei;Okamoto, Yasuo;Inoki, Isao;Yoshioka, Kazuaki;Takuwa, Noriko;Takuwa, Yoh JOURNAL OF PHARMACOLOGICAL SCIENCES 115 0 97P-97P 2011
- [Physiological roles of class II PI3 kinase-C2alpha in endothelial cells]. Yoshioka, Kazuaki; Takuwa, Noriko; Okamoto, Yasuo; Takuwa, Yoh Seikagaku. The Journal of Japanese Biochemical Society 85 9 775-780 2013/09/01
- Cardiovascular function of sphingosine 1-phosphate signaling Okamoto, Yasuo; Yoshioka, Kazuaki; Takuwa, Noriko; Takuwa, Yoh Seikagaku 83 6 536-544 2011/12/01
- G protein-coupled sphingosine-1-phosphate receptors: Potential molecular targets for angiogenic and anti-angiogenic therapies Takuwa, Noriko; Okamoto, Yasuo; Yoshioka, Kazuaki; Takuwa, Yoh Biomedical Reviews 22 15-29 2011/12/01
- Enhanced Ca2+-Dependent Activation of Phosphoinositide 3-Kinase Class IIα Isoform-Rho Axis in Blood Vessels of Spontaneously Hypertensive Rats. HYPERTENSION 56 934-941 2010/01
- Roles of Sphingosine Kinase and Sphingosine-1-Phosphate Receptor 2 in Endotoxin-Induced Acute Retinal Inflammation Tazbir Ahmed,Takafumi Suzuki,Ryo Terao,Reiko Yamagishi,Ryosuke Fujino,Kunihiro Azuma,Hirotsugu Soga,Takashi Ueta,Megumi Honjo,Sumiko Watanabe,Kazuaki Yoshioka,Yoh Takuwa,Makoto Aihara Ocular Immunology and Inflammation 32 8 1633 - 1647 2024/09/13
- Roles of Sphingosine Kinase and Sphingosine-1-Phosphate Receptor 2 in Endotoxin-Induced Acute Retinal Inflammation Tazbir Ahmed, Takafumi Suzuki, Ryo Terao, Reiko Yamagishi, Ryosuke Fujino, Kunihiro Azuma, Hirotsugu Soga, Takashi Ueta, Megiumi Honjo, Sumiko Watanabe, Kazuaki Yoshioka, Yoh Takuwa, Makoto Aihara Ocular Immunology and Inflammation 32 8 1633-1647 2024/09/13
- Evaluation of 2-[N-(7-nitrobenz-2-oxa-1,3-diazol-4-yl)amino]-2-deoxy-D-glucose, a new fluorescent derivative of glucose, for viability assessment of yeast Candida albicans K Yoshioka,KB Oh,M Saito,Y Nemoto,H Matsuoka APPLIED MICROBIOLOGY AND BIOTECHNOLOGY 46 4 400 1996/11
- A novel fluorescent derivative of glucose applicable to the assessment of glucose uptake activity of Escherichia coli K Yoshioka,H Takahashi,T Homma,M Saito,KB Oh,Y Nemoto,H Matsuoka BIOCHIMICA ET BIOPHYSICA ACTA-GENERAL SUBJECTS 1289 1 5 1996/02
- Analysis of olfactory function of the silkworm bombyx mori Yoshioka, K.,Homma, T.,Matsuoka, H. Electrochemistry 64 11 1138 1996
- Intracellular fate of 2-NBDG, a fluorescent probe for glucose uptake activity, in escherichia coli cells Kazuaki Yoshioka,Mikako Saito,Ki-Bong Oh,Yasuyuki Nemoto,Hideaki Matsuoka,Masahiro Natsume,Hiroshi Abe Bioscience, Biotechnology and Biochemistry 60 11 1899 1996
- Purinergic-receptor oligomerization: Implications for neural functions in the central nervous system H Nakata,K Yoshioka,T Kamiya NEUROTOXICITY RESEARCH 6 4 291 2004
- Negative regulation of endothelial morphogenesis and angiogenesis by S1P(2) receptor Inoki, I,N Takuwa,N Sugimoto,K Yoshioka,S Takata,S Kaneko,Y Takuwa BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 346 1 293 2006/07
- Rho-dependent, Rho kinase-independent inhibitory regulation of Rac and cell migration by LPA(1) receptor in G(i)-inactivated CHO cells N Sugimoto,N Takuwa,K Yoshioka,Y Takuwa EXPERIMENTAL CELL RESEARCH 312 10 1899 2006/06
- Determination of melatonin in commercially available products by LCEC and LC/MS/MS FM Xie,P Wong,K Yoshioka,RG Cooks,PT Kissinger JOURNAL OF LIQUID CHROMATOGRAPHY & RELATED TECHNOLOGIES 21 9 1273 1998
- Pharmacology of a unique adenosine binding site in rat brain using a selective ligand Kazuaki Yoshioka,Akira Matsuda,Hiroyasu Nakata Clinical and Experimental Pharmacology and Physiology 28 4 278 2001
- Oligomerization of adenosine A(2A) and dopamine D-2 receptors in living cells T Kamiya,O Saitoh,K Yoshioka,H Nakata BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 306 2 544 2003/06
- Essential role for class II phosphoinositide 3-kinase α-isoform in Ca2+-induced, Rho- and Rho kinase-dependent regulation of myosin phosphatase and contraction in isolated vascular smooth muscle cells Kazuaki Yoshioka,Naotoshi Sugimoto,Noriko Takuwa,Yoh Takuwa Molecular Pharmacology 71 3 912 2007/03
- Hetero-oligomerization of adenosine A(1) receptors with P2Y(1) receptors in rat brains K Yoshioka,R Hosoda,Y Kuroda,H Nakata FEBS LETTERS 531 2 299 2002/11
- In vivo microdialysis liquid chromatography tandem mass spectrometry for the on-line monitoring of melatonin in rat PSH Wong,K Yoshioka,F Xie,PT Kissinger RAPID COMMUNICATIONS IN MASS SPECTROMETRY 13 5 407 1999
- Sphingosine-1-phosphate signaling and biological activities in the cardiovascular system. Takuwa Y,Okamoto Y,Yoshioka K,Takuwa N Biochimica et biophysica acta 1781 483 2008/09
- Development of a novel fluorescent glucose and its application to probe for cell metabolic activity YOSHIOKA Kazuaki Doctoral Thesis (Tokyo University of Agriculture and Technology) 12605甲博工第140号 1997/03
- S1P(2), the G Protein-Coupled Receptor for Sphingosine-1-Phosphate, Negatively Regulates Tumor Angiogenesis and Tumor Growth In vivo in Mice Wa Du,Noriko Takuwa,Kazuaki Yoshioka,Yasuo Okamoto,Koichi Gonda,Kazushi Sugihara,Akiyoshi Fukamizu,Masahide Asano,Yoh Takuwa CANCER RESEARCH 70 2 772 2010/01
- Calcium-dependent regulation of Rho and myosin phosphatase in vascular smooth muscle Yoh Takuwa,Kazuaki Yoshioka,Noriko Takuwa,Yu Wang,Mohammed Ali Azam,Naotoshi Sugimoto Biomedical Reviews 16 13 2005 ?
- Agonist-promoted heteromeric oligomerization between adenosine A(1) and P2Y(1) receptors in living cells K Yoshioka,O Saitoh,H Nakata FEBS LETTERS 523 1-3 147 2002/07
- Pharmacology of a unique adenosine binding site in rat brain using a selective ligand K Yoshioka,A Matsuda,H Nakata CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY 28 4 278 2001/04
- Nucleosides and nucleotides. 200. Reinvestigation of 5 '-N-ethylcarboxamidoadenosine derivatives: Structure-activity relationships for P-3 purinoceptor-like proteins T Umino,K Yoshioka,Y Saitoh,N Minakawa,H Nakata,A Matsuda JOURNAL OF MEDICINAL CHEMISTRY 44 2 208 2001/01
- Hetero-oligomerization between adenosine A
1 and P2Y1 receptors in living cells: Formation of ATP-sensitive adenosine receptors Nakata, H.,Yoshioka, K.,Saitoh, O. Drug Development Research 58 4 340 2003/05 - Oligomerization of g protein-coupled purinergic receptors Nakata, H.,Yoshioka, K.,Kamiya, T. G Protein-Coupled Receptors: Structure, Function, and Ligand Screening 2005
- S1P(3)-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species Noriko Takuwa,Sei-Ichiro Ohkura,Shin-Ichiro Takashima,Keisuke Ohtani,Yasuo Okamoto,Tamotsu Tanaka,Kaoru Hirano,Soichiro Usui,Fei Wang,Wa Du,Kazuaki Yoshioka,Yoshiko Banno,Motoko Sasaki,Ikuyo Ichi,Miwa Okamura,Naotoshi Sugimoto,Kiyomi Mizugishi,Yasuni Nakanuma,Isao Ishii,Masayuki Takamura,Shuichi Kaneko,Shosuke Kojo,Kiyoshi Satouchi,Kunitoshi Mitumori,Jerold Chun,Yoh Takuwa CARDIOVASCULAR RESEARCH 85 3 484 2010/02
- Functions of heteromeric association between adenosine and P2Y receptors H Nakata,K Yoshioka,T Kamiya,H Tsuga,K Oyanagi JOURNAL OF MOLECULAR NEUROSCIENCE 26 2-3 233 2005
- Biology and electrochemistry .1. Analysis of olfactory function of the silkworm Bombyx mori K Yoshioka,T Homma,H Matsuoka DENKI KAGAKU 64 11 1138 1996/11
- The role of class II PI 3-kinase signaling pathway in physiology and diseases. Curr Biodata Targeted Proteins Database. Takuwa Y,yoshioka K,Okamoto Y,Takuwa N Current Biodata. Targeted Proteins database 1 2009
- ATP- and adenosine-mediated signaling in the central nervous system: Purinergic receptor complex: Generating adenine nucleotide-sensitive adenosine receptors K Yoshioka,H Nakata JOURNAL OF PHARMACOLOGICAL SCIENCES 94 2 88 2004/02
- Heteromeric association creates a P2Y-like adenosine receptor K Yoshioka,O Saitoh,H Nakata PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA 98 13 7617 2001/06
- Roles of sphingosine-1-phosphate signaling in angiogenesis. Takuwa Y,Du W,Qi X,Okamoto Y,Takuwa N,Yoshioka K World J Biol Chem. 1 10 298 2010
- S1P 3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species Noriko Takuwa,Sei-Ichiro Ohkura,Shin-Ichiro Takashima,Keisuke Ohtani,Yasuo Okamoto,Tamotsu Tanaka,Kaoru Hirano,Soichiro Usui,Fei Wang,Wa Du,Kazuaki Yoshioka,Yoshiko Banno,Motoko Sasaki,Ikuyo Ichi,Miwa Okamura,Naotoshi Sugimoto,Kiyomi Mizugishi,Yasuni Nakanuma,Isao Ishii,Masayuki Takamura,Shuichi Kaneko,Shosuke Kojo,Kiyoshi Satouchi,Kunitoshi Mitumori,Jerold Chun,Yoh Takuwa Cardiovascular Research 85 3 484 2010/02
- Sphingosine-1-phosphate signaling and biological activities in the cardiovascular system Yoh Takuwa,Yasuo Okamoto,Kazuaki Yoshioka,Noriko Takuwa BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 1781 9 483 2008/09
- G(12/13) and G(q) mediate S1P(2)-induced inhibition of Rac and migration in vascular smooth muscle in a manner dependent on Rho but not Rho kinase Shin-ichiro Takashima,Naotoshi Sugimoto,Noriko Takuwa,Yasuo Okamoto,Kazuaki Yoshioka,Masayuki Takamura,Shigeo Takata,Shuichi Kaneko,Yoh Takuwa CARDIOVASCULAR RESEARCH 79 4 689 2008/09
- Ca2+-independent, inhibitory effects of cyclic adenosine 5 '-monophosphate on Ca2+ regulation of phosphoinositide 3-kinase c2 alpha, Rho, and myosin phosphatase in vascular smooth muscle Mohammed Ali Azam,Kazuaki Yoshioka,Shinsuke Ohkura,Noriko Takuwa,Naotoshi Sugimoto,Koichi Sato,Yoh Takuwa JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS 320 2 907 2007/02
- Class II phosphoinositide 3-kinase alpha-isoform regulates Rho, myosin phosphatase and contraction in vascular smooth muscle Y Wang,K Yoshioka,MA Azam,N Takuwa,S Sakurada,Y Kayaba,N Sugimoto,Inoki, I,T Kimura,T Kuwaki,Y Takuwa BIOCHEMICAL JOURNAL 394 3 581 2006/03
- Nucleosides and nucleotides. 200. Reinvestigation of 5 '-N-ethylcarboxamidoadenosine derivatives: Structure-activity relationships for P-3 purinoceptor-like proteins T Umino,K Yoshioka,Y Saitoh,N Minakawa,H Nakata,A Matsuda JOURNAL OF MEDICINAL CHEMISTRY 44 2 208 2001/01
- LPA-induced YAP/TAZ activation promotes developmental angiogenesis by regulating Dll4 expression Yasuda D,Kobayashi D,Akahoshi N,Ohto-Nakanishi T,Yoshioka K,Takuwa Y,Mizuno S,Takahashi S,Ishii S J Clin Invest 129 10 4332 2019
- Sphingosine-1-phosphate receptor 2 protects against anaphylactic shock through suppression of endothelial nitric oxide synthase in mice Hong Cui,Yasuo Okamoto,Kazuaki Yoshioka,Wa Du,Noriko Takuwa,Wei Zhang,Masahide Asano,Toshishige Shibamoto,Yoh Takuwa Journal of Allergy and Clinical Immunology 132 5 1205 2013/11
- Early endothelialization associated with a biolimus A9 bioresorbable polymer stent in a porcine coronary model Masayuki Mori,Kenji Sakata,Chiaki Nakanishi,Takuya Nakahashi,Masa-aki Kawashiri,Kazuaki Yoshioka,Yoh Takuwa,Hirofumi Okada,Jun-ichiro Yokawa,Masaya Shimojima,Tsuyoshi Yoshimuta,Shohei Yoshida,Masakazu Yamagishi,Kenshi Hayashi HEART AND VESSELS 32 10 1244 2017/10
- Vascular endothelial S1P 2 receptor limits tumor angiogenesis and hyperpermeability Noriko Takuwa,Yasuo Okamoto,Kazuaki Yoshioka,Yoh Takuwa Bioactive Lipid Mediators: Current Reviews and Protocols 237 2015/01/01
- Sustained delivery of sphingosine-1-phosphate using poly(lactic-co-glycolic acid)-based microparticles stimulates Akt/ERK-eNOS mediated angiogenesis and vascular maturation restoring blood flow in ischemic limbs of mice Qi, X.,Okamoto, Y.,Murakawa, T.,Wang, F.,Oyama, O.,Ohkawa, R.,Yoshioka, K.,Du, W.,Sugimoto, N.,Yatomi, Y.,Takuwa, N.,Takuwa, Y. European Journal of Pharmacology 634 1-3 121 2010/05
- Enhanced Ca2+-Dependent Activation of Phosphoinositide 3-Kinase Class II alpha Isoform-Rho Axis in Blood Vessels of Spontaneously Hypertensive Rats Young Mi Seok,Mohammed Ali Azam,Yasuo Okamoto,Atsushi Sato,Kazuaki Yoshioka,Masataka Maeda,InKyeom Kim,Yoh Takuwa HYPERTENSION 56 5 934 2010/11
- Tumor-suppressive sphingosine-1-phosphate receptor-2 counteracting tumor-promoting sphingosine-1-phosphate receptor-1 and sphingosine kinase 1 Noriko Takuwa,Wa Du,Erika Kaneko,Yasuo Okamoto,Kazuaki Yoshioka,Yoh Takuwa AMERICAN JOURNAL OF CANCER RESEARCH 1 4 460 2011
- Sustained delivery of sphingosine-1-phosphate using poly(lactic-co-glycolic acid)-based microparticles stimulates Akt/ERK-eNOS mediated angiogenesis and vascular maturation restoring blood flow in ischemic limbs of mice Xun Qi,Yasuo Okamoto,Tomomi Murakawa,Fei Wang,Osamu Oyama,Ryunosuke Ohkawa,Kazuaki Yoshioka,Wa Du,Naotoshi Sugimoto,Yutaka Yatomi,Noriko Takuwa,Yoh Takuwa EUROPEAN JOURNAL OF PHARMACOLOGY 634 1-3 121 2010/05
- Endothelial PI3K-C2 alpha, a class II PI3K, has an essential role in angiogenesis and vascular barrier function Kazuaki Yoshioka,Kotaro Yoshida,Hong Cui,Tomohiko Wakayama,Noriko Takuwa,Yasuo Okamoto,Wa Du,Xun Qi,Ken Asanuma,Kazushi Sugihara,Sho Aki,Hidekazu Miyazawa,Kuntal Biswas,Chisa Nagakura,Masaya Ueno,Shoichi Iseki,Robert J. Schwartz,Hiroshi Okamoto,Takehiko Sasaki,Osamu Matsui,Masahide Asano,Ralf H. Adams,Nobuyuki Takakura,Yoh Takuwa NATURE MEDICINE 18 10 1560 2012/10
- Sphingosine kinase-2 prevents macrophage cholesterol accumulation and atherosclerosis by stimulating autophagic lipid degradation Ishimaru K,Yoshioka K,Kano K,Kurano M,Saigusa D,Aoki J,Yatomi Y,Takuwa N,Okamoto Y,Proia R,Takuwa Y SCIENTIFIC REPORT 9 1 13829 2019/12
- Class II PI3Ks α and β Are Required for Rho-Dependent Uterine Smooth Muscle Contraction and Parturition in Mice Md Azadul Kabir Sarker,Sho Aki,Kazuaki Yoshioka,Kouji Kuno,Yasuo Okamoto,Kazuhiro Ishimaru,Noriko Takuwa,Yoh Takuwa Endocrinology 160 1 235 2019/01/01
- Pancreas lineage allocation and specification are regulated by sphingosine-1-phosphate signalling Ioannis Serafimidis,Eva Rodriguez-Aznar,Mathias Lesche,Kazuaki Yoshioka,Yoh Takuwa,Andreas Dahl,Duojia Pan,Anthony Gavalas PLOS BIOLOGY 15 3 2017/03
- Sphingosine-1-phosphate signaling in physiology and diseases Yoh Takuwa,Yasuo Okamoto,Kazuaki Yoshioka,Noriko Takuwa BIOFACTORS 38 5 329 2012/09
- Sphingosine-1-phosphate-specific G protein-coupled receptors as novel therapeutic targets for atherosclerosis Yasuo Okamoto,Fei Wang,Kazuaki Yoshioka,Noriko Takuwa,Yoh Takuwa Pharmaceuticals 4 1 117 2011
- Phosphatidylinositol 3-Kinase Class II alpha-Isoform PI3K-C2 alpha Is Required for Transforming Growth Factor beta-induced Smad Signaling in Endothelial Cells Sho Aki,Kazuaki Yoshioka,Yasuo Okamoto,Noriko Takuwa,Yoh Takuwa JOURNAL OF BIOLOGICAL CHEMISTRY 290 10 6086 2015/03
- Sphingosine-1-phosphate as a mediator involved in development of fibrotic diseases Takuwa, Y.,Ikeda, H.,Okamoto, Y.,Takuwa, N.,Yoshioka, K. Biochimica et Biophysica Acta - Molecular and Cell Biology of Lipids 1831 1 185 2013/01
- Essential Role of Class II Phosphatidylinositol-3-kinase-C2 alpha in Sphingosine 1-Phosphate Receptor-1-mediated Signaling and Migration in Endothelial Cells Kuntal Biswas,Kazuaki Yoshioka,Ken Asanuma,Yasuo Okamoto,Noriko Takuwa,Takehiko Sasaki,Yoh Takuwa JOURNAL OF BIOLOGICAL CHEMISTRY 288 4 2325 2013/01
- MTMR4, a phosphoinositide‐specific 3’‐phosphatase, regulates TFEB activity and the endocytic and autophagic pathways Hoa Q. Pham,Kazuaki Yoshioka,Hiromi Mohri,Hiroki Nakata,Sho Aki,Kazuhiro Ishimaru,Noriko Takuwa,Yoh Takuwa Genes to Cells 23 8 670 2018/08
- Photoacoustic imaging of tumour vascular permeability with indocyanine green in a mouse model. Kenichiro Okumura,Kotaro Yoshida,Kazuaki Yoshioka,Sho Aki,Norihide Yoneda,Dai Inoue,Azusa Kitao,Takahiro Ogi,Kazuto Kozaka,Tetsuya Minami,Wataru Koda,Satoshi Kobayashi,Yoh Takuwa,Toshifumi Gabata European radiology experimental 2 1 5 2018
- Sphingosine-1-phosphate receptor-2 facilitates pulmonary fibrosis through potentiating IL-13 pathway in macrophages Juanjuan Zhao,Yasuo Okamoto,Yuya Asano,Kazuhiro Ishimaru,Sho Aki,Kazuaki Yoshioka,Noriko Takuwa,Takashi Wada,Yutaka Inagaki,Chiaki Takahashi,Takumi Nishiuchi,Yoh Takuwa PLoS ONE 13 5 e0197604 2018/05/01
- Sphingosine-1-phosphate as a mediator involved in development of fibrotic diseases Yoh Takuwa,Hitoshi Ikeda,Yasuo Okamoto,Noriko Takuwa,Kazuaki Yoshioka BIOCHIMICA ET BIOPHYSICA ACTA-MOLECULAR AND CELL BIOLOGY OF LIPIDS 1831 1 185 2013/01
- Analysis of various types of single-polypeptide-chain (sc) heterodimeric A(2A)R/D2R complexes and their allosteric receptor receptor interactions Toshio Kamiya,Kazuaki Yoshioka,Hiroyasu Nakata BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS 456 2 573 2015/01
- Aldosterone inhibits endothelial morphogenesis and angiogenesis through the downregulation of vascular endothelial growth factor receptor-2 expression subsequent to peroxisome proliferator-activated receptor gamma Miki Fujii,Isao Inoki,Makoto Saga,Norihiro Morikawa,Ken-ichiro Arakawa,Satoru Inaba,Kazuaki Yoshioka,Tadashi Konoshita,Isamu Miyamori JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY 129 3-5 145 2012/04
- G protein-coupled sphingosine-1-phosphate receptors: Potential molecular targets for angiogenic and anti-angiogenic therapies Noriko Takuwa,Yasuo Okamoto,Kazuaki Yoshioka,Yoh Takuwa Biomedical Reviews 22 15 2011
- Sphigosine-1-phosphate receptor 1 promotes neointimal hyperplasia in a mouse model of carotid artery injury. Teppei Kitano,Soichiro Usui,Shin-Ichiro Takashima,Oto Inoue,Chiaki Goten,Ayano Nomura,Kazuaki Yoshioka,Masaki Okajima,Shuichi Kaneko,Yoh Takuwa,Masayuki Takamura Biochemical and biophysical research communications 511 1 179 2019/03/26
- The class II phosphoinositide 3-kinases PI3K-C2α and PI3K-C2β differentially regulate clathrin-dependent pinocytosis in human vascular endothelial cells Aung, K.T.,Yoshioka, K.,Aki, S.,Ishimaru, K.,Takuwa, N.,Takuwa, Y. Journal of Physiological Sciences 69 2 263 2019/03
- Lysophosphatidic acid-induced YAP/TAZ activation promotes developmental angiogenesis by repressing Notch ligand Dll4 Yasuda Daisuke,Kobayashi Daiki,Akahoshi Noriyuki,Ohto-Nakanishi Takayo,Yoshioka Kazuaki,Takuwa Yoh,Mizuno Seiya,Takahashi Satoru,Ishii Satoshi JOURNAL OF CLINICAL INVESTIGATION 129 10 4332 2019/10
- Pancreas lineage allocation and specification are regulated by sphingosine-1-phosphate signalling Ioannis Serafimidis,Eva Rodriguez-Aznar,Mathias Lesche,Kazuaki Yoshioka,Yoh Takuwa,Andreas Dahl,Duojia Pan,Anthony Gavalas PLoS Biology 15 3 e2000949 2017/03/01
- Augmented sphingosine 1 phosphate receptor-1 signaling in cardiac fibroblasts induces cardiac hypertrophy and fibrosis through angiotensin II and interleukin-6 Sei-ichiro Ohkura,Soichiro Usui,Shin-ichiro Takashima,Noriko Takuwa,Kazuaki Yoshioka,Yasuo Okamoto,Yutaka Inagaki,Naotoshi Sugimoto,Teppei Kitano,Masayuki Takamura,Takashi Wada,Shuichi Kaneko,Yoh Takuwa PLOS ONE 12 8 e0182329 2017/08
- Sphingosine-1-Phosphate Signaling and Cardiac Fibrosis. Takuwa N,Okamoto Y,Yoshioka K,Takuwa Y Inflammation and Regeneration 33 2 96 2013
- Overexpression of Sphingosine Kinase 1 Prevents Ceramide Accumulation and Ameliorates Muscle Insulin Resistance in High-Fat Diet-Fed Mice Clinton R. Bruce,Steve Risis,Joanne R. Babb,Christine Yang,Greg M. Kowalski,Ahrathy Selathurai,Robert S. Lee-Young,Jacquelyn M. Weir,Kazuaki Yoshioka,Yoh Takuwa,Peter J. Meikle,Stuart M. Pitson,Mark A. Febbraio DIABETES 61 12 3148 2012/12
- Differences in collagen types in the semitendinosus, quadriceps, and patellar tendons: A report using samples from an 11-year-old patient Yushin Mizuno,Junsuke Nakase,Kazuaki Yoshioka,Takuya Sengoku,Rikuto Yoshimizu,Tomoyuki Kanayama,Yusuke Yanatori,Hiroyuki Tsuchiya Knee May 4 339 2023/05
- Sphingosine Kinase 1 is Involved in Triglyceride Breakdown by Maintaining Lysosomal Integrity in Brown Adipocytes Jun-ichi Morishige,Kazuaki Yoshioka,Hiroki Nakata,Kazuhiro Ishimaru,Naoto Nagata,Tamotsu Tanaka,Yoh Takuwa,Hitoshi Ando Journal of Lipid Research 100450 2023/09
- One-Year Changes in Collagen Type in Semitendinosus Tendons: A Case Study Using Tissues Obtained From a Growing Patient. Yushin Mizuno,Yasushi Takata,Kazuaki Yoshioka,Satoru Demura,Junsuke Nakase Cureus 16 8 e67564 2024/08
- Semitendinosus tendons in physically immature patients have a lower type I collagen content. Yushin Mizuno,Yasushi Takata,Kazuaki Yoshioka,Naoki Takemoto,Manase Nishimura,Kentaro Fujita,Takuya Sengoku,Sakae Miyagi,Satoru Demura,Junsuke Nakase Knee surgery, sports traumatology, arthroscopy : official journal of the ESSKA 2025/04/03
- The ATG5 interactome links clathrin-mediated vesicular trafficking with the autophagosome assembly machinery Kiren Baines,Kazuaki Yoshioka,Yoh Takuwa,Jon D. Lane Autophagy Reports 1 1 88 2021/12/31
- Adipose-Derived Stem Cell Sheets Promote Meniscus Regeneration Regardless of Whether the Defect Involves the Inner Half or the Whole Width of the Anterior Half of the Medial Meniscus in a Rabbit Model Kazuki Asai,Junsuke Nakase,Kazuaki Yoshioka,Rikuto Yoshimizu,Mitsuhiro Kimura,Hiroyuki Tsuchiya Arthroscopy 38 9 2672 2022/09
- Class II phosphatidylinositol 3-kinase α and β isoforms are required for vascular smooth muscle Rho activation, contraction and blood pressure regulation in mice. Shahidul Islam,Kazuaki Yoshioka,Sho Aki,Kazuhiro Ishimaru,Hiroki Yamada,Noriko Takuwa,Yoh Takuwa The journal of physiological sciences : JPS 70 1 18 2020/03/19
- Everolimus-Eluting Biodegradable Abluminal Coating Stent versus Durable Conformal Coating Stent: Termination of the Inflammatory Response Associated with Neointimal Healing in a Porcine Coronary Model. Masayuki Mori,Kenji Sakata,Junichiro Yokawa,Chiaki Nakanishi,Kota Murai,Hirofumi Okada,Masaya Shimojima,Shohei Yoshida,Kazuaki Yoshioka,Yoh Takuwa,Kenshi Hayashi,Masakazu Yamagishi,Masa-Aki Kawashiri Journal of interventional cardiology 2020 8 1956015 2020
- Suppression of androgen receptor signaling induces prostate cancer migration via activation of the CCL20–CCR6 axis Kano, Hiroshi,Izumi, Kouji,Hiratsuka, Kaoru,Toriumi, Ren,Nakagawa, Ryunosuke,Aoyama, Shuhei,Kamijima, Taiki,Shimada, Takafumi,Naito, Renato,Kadomoto, Suguru,Iwamoto, Hiroaki,Yaegashi, Hiroshi,Kawaguchi, Shohei,Nohara, Takahiro,Shigehara, Kazuyoshi,Kadono, Yoshifumi,Saito, Yohei,Nakagawa-Goto, Kyoko,Yoshioka, Kazuaki,Nakata, Hiroki,Lin, Wen-Jye,Mizokami, Atsushi Cancer Science 114 4 1479 2023/04
- Class II phosphatidylinositol 3-kinase-C2α is essential for Notch signaling by regulating the endocytosis of γ-secretase in endothelial cells Shota Shimizu,Kazuaki Yoshioka,Sho Aki,Yoh Takuwa Scientific Reports 11 1 2021/12
- Class II phosphatidylinositol 3-kinase isoforms in vesicular trafficking Kazuaki Yoshioka Biochemical Society Transactions 49 2 893 2021/04/30 ?
- TGFβ receptor endocytosis and Smad signaling require synaptojanin1, PI3K-C2α-, and INPP4B-mediated phosphoinositide conversions. Sho Aki,Kazuaki Yoshioka,Noriko Takuwa,Yoh Takuwa Molecular biology of the cell 31 5 360 2020/03/01
- Sphingosine-1-phosphate receptor-2 deficiency leads to inhibition of macrophage proinflammatory activities and atherosclerosis in apoE-deficient mice (Journal of Clinical Investigation (2010) 120, 11, (3979-3995) DOI:10.1172/JCI42315) Wang F,Okamoto Y,Inoki I,Yoshioka K,Du W,Qi X,Takuwa N,Gonda K,Yamamoto Y,Ohkawa R,Nishiuchi T,Sugimoto N,Yatomi Y,Mitsumori K,Asano M,Kinoshita M,Takuwa Y Journal of Clinical Investigation 122 3 1131 2012/03
- Differences in Collagen Types in the Semitendinosus, Quadriceps, and Patellar Tendons: The Report Using Samples from the Same Individual. Yushin Mizuno, Junsuke Nakase, Kazuaki Yoshioka, Takuya Sengoku, Rikuto Yoshimizu, Tomoyuki Kanayama, Yusuke Yanatori, Hiroyuki Tsuchiya The Knee in press 2023
Conference Presentations
- Essential role of class II PI3K in endocytosis and endosomal signaling(conference：9th Federation of the Asia and Oceanian Physiological Societies (FAOPS2019) )(2019/03/28)
- Class II phosphoinositide 3-kinase isoforms PI3K-C2α and PI3K-C2β play essential roles in pinocytosis in vascular endothelial cells(2018/03/28)
- Indispensable role of α and β isoforms of class II phosphoinositide 3-kinases (PI3K) in the uterine smooth muscle contraction during labor(2018/03/28)
- Myotubularin-related protein 4 (MTMR4), a phosphoinositide 3'-phosphatase, regulates endolysosome integrity and autophagy flux in human lung alveolar epithelial A549 cells(2018/03/28)
- Endothelial Class II PI3K-C2α is necessary for vascular formation and integrity through regulating endocytic membrane trafficking(2017/03/18)
- PI3K-C2α is required for TGFβ-induced receptor endocytosis and endosomal signaling in endothelial cells.(2016/03/24)
- Sphingosine 1-phosohate receptor-2 plays a protective role against lopopolysaccharide (LPS)-induced acute lung injury(2016/03/22)
- Sphingosine-1-phosphate receptor-2 plays a protective role against anaphylactic shock through inhibiting eNOS.(2013)
- Essential role of class Iiα-isoform PI3 kinase C2α in sphingosine-1-phosphate (S1P)-induced endothelial cell migration.(2013/03/28)
- Class II PI3 kinase, PI3K-C2α, mediates S1P-induced endothelial cell migration through endosomal Rac1 activation.(conference：Gordon Research Conference on Vascular Cell Biology)(2013/02/01)
- Class II PI3K-C2α is essential for vascular barrier integrity.” JST-CREST International Symposium “Frontiers in Immunology and Inflammation: From Molecules and Inflammation(conference：JST-CREST International Symposium “Frontiers in Immunology and Inflammation: From Molecules and Inflammation.”)(2013/02/13)
- 蛍光イメージングが拓く見せる血管生物学(2013/09/26)
- Endothelial class II PI3K-C2α has an essential role in vascular formation and barrier function(conference：Gordon Research Conference on Vascular Cell Biology)(2013/02/01)
- クラスII型PI3キナーゼC2αは血管形成・血管恒常性維持に必須である(2012/12/14)
- Determination of neurotransmitters in insect brains using automated micro solid phase extraction and microbore liquid chromatography/ electrochemistry.(conference：22nd International Symposium on High Performance Liquid Phase Separations and Related Techniques, Saint Louis, Missouri (USA))(1998/05/02)
- 2-NBDG, a novel fluorescent probe of glucose metabolism: The properties of 2-NBDG transport and metabolic activities in Escherichia coli.(conference：The 1995 International Chemical Congress of Pacific Basin Societies, Honolulu, Hawaii (USA))(1995/12/17)
- Associative learning in silkworm, Bombyx mori by classical conditioning method(conference：4th IBRO World Congress of Neuroscience, Kyoto (Japan))(1995/07/09)
- Determination of melatonin in biological samples and commercially available products by LCEC and LC/MS/MS.(conference：22nd International Symposium on High Performance Liquid Phase Separations and Related Techniques, Saint Louis, Missouri (USA))(1998/05/02)
- Sphingosine-1-phosphate receptor-2 inhibits tumor angiogenesis and tumor growth in vivo in mice(conference：Keystone Symposia Bioactive Lipids: Biochemistry and Diseases)(2010/06/06)
- Role of Lysophospho lipid Mediator Sphingosine-1-phosphate in Cardiac Fibrosis(conference：1st Meeting of Asian-Pacific Federation of Inflammation and Regeneration /)(2011/06/02)
- Endothelial class II PI3K-C2α has an essential role for physiological and pathological angiogenesis.(conference：日本分子生物学会第11回春季シンポジウム)(2011/05/25)
- Forskolin inhibition of membrane depolarization-induced vascular smooth muscle contraction involves suppression of Ca2+-dependent Rho activation and myosin phosphatase inhibition(conference：第78回 日本生化学会、神戸ポートアイランド（神戸）)(2005/10/19)
- Phosphoinositide 3-kinase class IIα regulates vascular smooth muscle contraction through Rho/Rho kinase and myosin phosphatase(conference：第78回 日本生化学会、神戸ポートアイランド（神戸）)(2005/10)
- Development of decompensated cardiac hypertrophy with fibrosis in transgenic mice that overexpress S1P1 under the control of a smooth muscle actin promoter(conference：第79回日本生化学会大会)(2006/06)
- カルシウムイオンによるRac，Racキナーゼ依存的なミオシン軽鎖ホスファターゼの抑制-PI3キナーゼ・クラスIIaの関与(conference：第16回日本循環薬理学会)(2006/11)
- Host sell S1P2 receptor (S1P2R) negatively regulates tumor growth and angiogenesis in vivo.(conference：第16回日本血管生物医学会学術集会、The 6th Korea-Japan Joint Symposium on Vascular Biology)(2008/09/14)
- G12/13 and Gq Coordinately Mediate S1P2-induced Inhibition of Rac and Migration in Vascular Smooth Muscle in Rho-dependent Manner(conference：第73回日本循環器学会)(2009/03/20)
- HOST CELL S1P2 RECEPTOR NEGATIVELY REGULATES TUMOR GROWTH AND ANGIOGENESIS IN VIVO(conference：International Conference on Phospholipase A2 and Lipid Mediators)(2009/05/25)
- RHO- MLC PHOSPHATASE PATHWAY IN HYPERTENSION(conference：The 36th Congress of the International Union of Physiological Sciences)(2009/07/27)
- Development of Cardiac Fibrosis in Sphingosine Kinase 1 Transgenic Mice through an S1P3 Receptor-mediated, Reactive Oxygen Species-dependent Process(conference：第74回日本循環器学会総会)(2010/03/05)
- A novel mechanism of Ca2+ regulation of vascular smooth muscle contraction involving classII PI3 kinase-dependent inhibition of myosin light chain phoisphatase(conference：1st International Symposium of Biorheology)(2010/06/02)
- Identification of class II phosphoinositide 3-kinase α-isoform as a regulator of myosin phosphatase and contraction in vascular smooth muscle cells(conference：第79回日本生化学会大会)(2006/06)
- BRET2を用いたGタンパク質共役型受容体間ヘテロ複合体形成の解析(2002/05/21)
- Function role of sphingosine-1-phosphate signaling in angiogenesis.(conference：The 1st Asia-Pacific Vascular Biology Meeting/)(2011/12/08)
- Signaling of vascular smooth muscle contraction.(conference：第1回国際バイオレオロジーシンポジウム)(2010/06/01)
- Cyclic AMP prevents class II α-isoform of phosphoinositide 3-kinase (PI3K-C2α)- and ROCK-dependent inhibition of myosin light chain phosphatase (MLCP) in vascular smooth muscledai(conference：第49回日本脂質生化学会)(2007/05)
- スフィンゴシン-1-リン酸受容体1(S1P1)トランスジェニックマウスにおける病的肥大心の発症と病態生理(conference：第48回日本脂質生化学会)(2006/06)
- Orexin-A administered intravenously increases glutamate in the rat locus(conference：Society for Neuroscience 31st annual meeting, San Diego Convention Center, CA (USA))(2001/11/12)
- Class II PI3 kinase C2α has a crucial role in vascular formation and barrier integrity(conference：第20回日本血管生物医学会、あわぎんホール（徳島県）)(2012/12/05)
- Ca2+-independent, inhibitory effects of cyclic AMP on Ca2+ regulation of phosphoinositide 3-kinase C2α, Rho and myosin phosphatase in vascular smooth muscle.(conference：第84回日本生理学会大会)(2007/03/20)
- Sphingosine-1-phosphate signaling in tumor biology(conference：THE U.S.-JAPAN COOPERATIVE CANCER RESEARCH PROGRAM WORKSHOP)(2007)
- Ca2+ regulation of smooth muscle myosin phosphatase and Ca2+ sensitization. International(conference：International Union of Physiological Sciences (IUPS) 2005. Symposium “Emerging modes of Ca2+ signaling in the regulation of smooth muscle contractile proteins., San Diego (U.S.A.))(2005/03/31)
- Investigation of contractile mechanisms using differentiated, cultured vascular smooth muscle cells and gene manipulation techniques(2005/05/18)
- The pathophysiolosical roles of phosphoinositide 3-kinase (PI3K) class II α-isoform, a Ca2+-dependent regulator of Rho in vascular smooth muscle, in vascular contraction and blood pressure regulation(conference：Post-Genomic Advances in the Physiology of Smooth Muscle Satellite Symposium of IUPS2009)(2009/07/27)
- Age-dependent progression of cardiac fibrosis but not spontaneous malignancy in sphingosine kinase 1 transgenic mice(conference：第79回日本生化学会大会)(2006/06/06)
- Forskolin inhibits membrane depolarization-induced Rho activation and contraction through inhibition of PI3K-C2α in Vascular Smooth Muscle.(conference：第79回日本生化学会大会)(2006/06)
- PI3キナーゼ・クラスIIαはRho活性化を介してカルシウム依存性血管平滑筋収縮を制御する(conference：第48回日本脂質生化学会)(2006/06)
- 血管平滑筋におけるカルシウム依存的Rho活性化を制御するシグナル分子PIK-C2αの同定(conference：第83回 日本生理学会、 群馬県民会館・前橋商工会議所（前橋）)(2006/03)
- Class II PI3K-C2α is essential for vascular barrier integrity.(conference：IEIIS2012 Homeostatic Inflammation Symposium)(2012/10/23)
- スフィンゴシン−1−リン酸による血管内皮細胞遊走におけるクラスII 型PI3 キナーゼC2α の役割(conference：第89回日本生理学会大会)(2012/03/29)
- Sustained delivery of sphingosine-1-phosphate (S1P) by using PLGA microparticles stimulates post-ischemic angiogenesis.(conference：第16回日本血管生物医学会学術集会、The 6th Korea-Japan Joint Symposium on Vascular Biology)(2008/09/14)
- Negative regulation of myosin phosphatase by Ca2+ in vascular smooth muscle: involvement of the novel Rho regulator phosphoinositide 3-kinase class IIα isoform.(conference：Federation of Asian and Oceanian Physiolgical Scientists 2006. Symposium “ Regulation of vascular tone”.)(2006/10/15)
- Sphingosine-1-phosphate negatively regulates endothelial morphogenesis and angiogenesis via its receptor S1P2(conference：第79回日本生化学会大会)(2006/06)
- Sphingosine-1-phosphate receptor-2（S1P2R）negatively regulates tumor angiogenesis, vascular maturation and integrity in vivo(conference：第85回日本生理学会)(2007/03)
- スフィンゴシンー１−リン酸はEdg5受容体を介して血管内皮細胞の形態形成および血管新生を抑制する(conference：第82回日本生理学会大会)(2005/05)
- cAMPは血管平滑筋における膜脱分極誘発カルシウム依存性Rho活性化及びミオシン脱リン酸化酵素抑制を阻害する(conference：第82回日本生理学会大会)(2005/05)
- Class II PI3K-C2α is essential for vascular barrier integrity(conference：International Endotoxin and Innate Immunity Society Meeting 2012 JST-CREST International Symposium"Frontiers in Immunology & Inflammation: From Molecules to Disease" Hitotsubashi Memorial Hall, Tokyo (Japan))(2012/11/16)
- Involvement of the Ca2+-PI3K-C2α-Rho-MLC phosphatase pathway in hypertension.(conference：IUPS2009 (36th International Congress of Physiological Sciences))(2009/07/27)
- The pathophysiological roles of phosphoinositide 3-kinase (PI3K) class II α-isoform, a Ca2+-dependent regulator of Rho in vascular smooth muscle, in vascular contraction and blood pressure regulation(conference：IUPS2009 Symposium)(2009/07/23)
- Role phosphoinosititide 3-kinase (PI3K) class II α isoform, a novel Ca2+-dependent regulator of Rho in vascular smooth muscle, in hypertension(conference：第16回日本血管生物医学会学術集会、The 6th Korea-Japan Joint Symposium on Vascular Biology)(2008/09/14)
- PI3K-C2αは血管平滑筋細胞のイオノマイシンによるCa2+依存的Rho活性化と収縮に必須である。(conference：第83回 日本生理学会)(2006/03)
- Phosphoinositide 3-kinase regulates Rho, myosin phosphatase and contraction in vascular smooth muscle(conference：79回日本生化学会大会、)(2006/06)
- S1P受容体S1P2による細胞遊走抑制はがん抑制遺伝子産物PTENに依存しない(conference：第48回日本脂質生化学会)(2006/06)
- クラスII型PI3キナーゼC2αノックアウトマウスにおける血管障壁機能の異常(conference：第89回日本生理学会大会)(2012/03/29)
- Generation of a novel functional property by oligomerization between adenosine and ATP receptors(conference：Society for Neuroscience 31st annual meeting, San Diego Convention Center, CA (USA))(2001/11/11)
- サイクリックAMPによる血管平滑筋Ca2+-PI3KC2α- Rho経路の調節(conference：筋生理の集い)(2006/12)
- Differential roles of class II PI3K in endocytosis and endosomal signaling(conference：60th International Conference on the Bioscience of Lipids, Hitotsubashi Hall (Tokyo))(2019/06/17)
- Class II phosphoinositide 3-kinase isoforms PI3K-C2α and PI3K-C2β play essential roles in pinocytosis in vascular endothelial cells(conference：第 95 回日本生理学会大会)(2018/03/28)
- Phosphoinositide-specific 3'-phosphatase, myotubularin-related protein 4 (MTMR4), regulates lysosomal activity and autophagy(conference：第94回日本生理学会大会)(2017/03/28)
- Endothelial PI3K-C2α, a class II PI3K, has an essential role in angiogenesis and vascular barrier function.(conference：Gordon Reseach Conference Vascular Cell Biology, Ventura, CA, (USA))(2016/01/27)
- Sphingosine 1-phosphate receptor-2 plays a protective role against lipopolysaccharide (LPS)-induced acute lung injury(conference：第92回日本生理学会大会、神戸国際会議場・展示場(兵庫県神戸市))(2015/03/21)
- Phosphatidylinositol 3-kinase class II α-isoform PI3K-C2α is required for transforming growth factor β-induced receptor endocytosis and endosomal signaling in endothelial cells(conference：The 39th Annual Meeting of the Molecular Biology Society of Japan)(2016/11/30)
- New pathophysiology of human aortic dissection through single-cell RNA-seq analysis(conference：KitaKyushu International Conference Center, West Japan General Exhibition Center)(2024/03/30)
- Essential role of class II PI3K in endocytosis and endosomal signaling(conference：9th Federation of the Asia and Oceanian Physiological Societies (FAOPS2019) Symposium: Dynamics of membrane trafficking and intracellular signaling. (Kobe, Japan))(2019/03/28)
- Indispensable role of α and β isoforms of class II phosphoinositide 3-kinases (PI3K) in the uterine smooth muscle contraction during labor(conference：第 95 回日本生理学会大会)(2018/03/28)
- Myotubularin-related protein 4 (MTMR4), a phosphoinositide 3'-phosphatase, regulates endolysosome integrity and autophagy flux in human lung alveolar epithelial A549 cells(conference：第 95 回日本生理学会大会)(2018/03/28)
- Myotubularin-related protein 4 (MTMR4), a phosphoinositide 3'-specifc phosphatase, regulates endolysosome integrity and autophagy ?ux in A549 human lung carcinoma cells(conference：第40回日本分子生物学会年会)(2017/12/07)
- Endothelial Class II PI3K-C2α is necessary for vascular formation and integrity through regulating endocytic membrane trafficking(2017/03/18)
- S1P2, A Receptor for the Lysophospholipid Mediator Sphingosine 1-phosphate, Protects Against Vascular Barrier Disruption(conference：International Shock Congress Symposium "Microcirculation and endothelial damage in sepsis and shock" , Tokyo Dome Hotel (Tokyo))(2016/10/03)
- Phosphatidylinositol 3-kinase class IIα isoform PI3K-C2α is required for transforming growth factor β-induced receptor endocytosis and endosomal signaling in endothelial cells.(conference：第２回春期特別日本血管生物医学会シンポジウム)(2016/06/03)
- Distinct role of S1P2 in the functional regulation of vascular endothelium and smooth muscle(conference：The 18th International Vascular Biology Meeting 2014 (IVBM 2014)、みやこめっせ（京都府京都市）)(2014/04/14)
- Class II PI3-kinase, PI3K-C2α, mediates S1P-induced endothelial cell migration through endosomal Rac1 activation(conference：Gordon Reseach Conference Vascular Cell Biology, Ventura, CA, (USA))(2016/01/27)
- Sphingosine 1-phosphate receptor-2 plays a protective role against anaphylaxis and acute lung injury(conference：第10回スフィンゴテラピィ（STC）研究会、ホテルアローレ（石川県）)(2015/06/16)
- Novel role of class II PI 3-kinase in in tumor angiogenesis(conference：International Symposium on Tumor Microenvironment. –Crosstalk between host and malignant cells –, Kanazawa University (Kanazawa, Japan))(2014/11/21)
- クラスIIα型PI3K-C2αはALK5 内在化及び足場タンパクSARA のエンドソームへの動員を制御しTGFβ1-Smad2/3 を介した血管新生を調節する(conference：第56回 日本脂質生化学会)(2014/06/06)
- クラスII 型PI3K-C2αはメンブレン・トラフィック調節を介して血管バリア機能を制御する(conference：第91回日本生理学会大会 シンポジウム「心血管系の形態・機能研究の最前線」、鹿児島大学 郡元キャンパス（鹿児島県鹿児島市）)(2014/03/15)
- S1P2は内皮型一酸化窒素合成酵素を抑制することによりアナフラキシーショックに対して防御的に働く(conference：第55回日本脂質生化学会)(2013/06/06)
- クラスII 型PI3 キナーゼC2α はエンドソーム上でのS1P によるRac1 活性化を制御して内皮細胞遊走を調節する(conference：第90回日本生理学会、タワーホール船堀（東京）)(2013/03/27)
- Class II PI3 kinase, PI3K-C2α, mediates S1P-induced endothelial cell migration through endosomal Rac1 activation.(conference：Gordon Research Conference on Vascular Cell Biology, Ventura, CA, USA)(2013/01/27)
- Role of S1P2 in inflammation and fibrosis(conference：14 th International Conference on Bioactive Lipids in Cancer, Budapest (Hungary))(2015/07/12)
- クラス II PI3-キナーゼ PI3K-C2αはエンドソーム上でのTGFβ/Smad2/3シグナリングに必須である(conference：第62回 中部日本生理学会)(2015/11/13)
- クラスII 型PI3 キナーゼ-C2α によるTGFβ 血管内皮作用の調節機構(conference：第61回中部日本生理学会、名古屋市立大学桜山キャンパス（愛知県名古屋市）)(2014/11/06)
- Endothelial class II PI3K-C2α has an essential role in vascular formation and barrier function(conference：Gordon Research Conference on Vascular Cell Biology, Ventura, CA, USA)(2013/01/27)
- S1P2 aggravates lung fibrosis through altering alveolar macrophage. polarization in mice(conference：the 9th Federation of the Asian and Oceanian Physiological Societies Congress (FAOPS2019), Kobe, Japan)(2019/03/28)
- S1P2 による血管新生と血管障壁機能の制御(conference：第58回 日本脂質生化学会 シンポジウム：リゾリン脂質による血管新生制御、にぎわい交流館AU（秋田）)(2016/06/09)
- Sphingosine-1-phosphate receptor-2 (S1P2) negatively regulates eNOS and protects against acute vascular barrier disruption(conference：The 18th International Vascular Biology Meeting 2014 (IVBM 2014)、みやこめっせ（京都府京都市）)(2014/04/14)
- Single cell RNA-sequencing analysis of the human aortic diseases(2023/11/18)
- Phosphotidylinositol 3-kinase Class II isoforms, PI3K-C2α and PI3K-C2β are necessary for Pinocytosis in Endothelial Cells(conference：第94回日本生理学会大会)(2017/03/28)
- S1P受容体はeNOS-NO経路を抑制することによりアナフラキシーショックに対して抑制的に働く(conference：第21回日本血管生物医学会、千里阪急ホテル（大阪府豊中市）)(2013/09/26)
- Sequential phosphoinositide conversion is required for transforming growth factor β-induced receptor endocytosis and Smad2/3 activation in endothelial cells(conference：60th International Conference on the Bioscience of Lipids, Hitotsubashi Hall (Tokyo))(2019/06/17)
- クラスII 型PI3K-C2αはSARA のエンドソームへの動員を制御しTGFβ1-Smad2/3シグナル伝達系を介した血管新生を調節する(conference：第36回日本分子生物学会、神戸国際会議場/神戸国際展示場/神戸ポートピアホテル（兵庫県神戸市）)(2013/12/03)
- Differential roles of class II PI3-kinase-C2α and -C2β in clathrin-mediated fluid phase endocytosis in vascular endothelial cells(2020/03/19)
- スフィンゴシン1-リン酸特異的2 型受容体は内皮型一酸化窒素合成酵素を抑制することによりアナフィラキシーショックに対して保護的に働く(conference：タワーホール船堀（東京）第90回日本生理学会)(2013/03/27)
- Class II PI3Ks a and b Are Required for Rho-Dependent Uterine Smooth Muscle Contraction and Parturition in Mice(2020/03/17)
- Sequential phosphoinositide conversion is required for TGFβ-induced receptor endocytosis in ECs.(conference：the 9th Federation of the Asian and Oceanian Physiological Societies Congress (FAOPS2019), Kobe, Japan)(2019/03/28)
- Sphingosine 1-phospahte (S1P) receptor-2 (S1P2) aggravates lung fibrosis through altering alveolar macrophage polarization and cellular senescence in mice(conference：日本生化学会北陸支部第３４回大会)(2016/05/28)
- Single-cell RNA-sequencing analysis of the vascular remodeling in human dissecting aorta(conference：Fukuoka International Congress Center, MARINE MESSE FUKUOKA Hall B)(2023/10/31)
- PI3K-C2α is required for TGFβ-induced receptor endocytosis and endosomal signaling in endothelial cells(conference：第93回 日本生理学会)(2016/03/22)
- Novel indispensable role of and isoforms of class II PI3K for uterine smooth muscle contraction and labor(conference：第54回北陸生殖医学会学術講演会)(2018/06/03)
- Deletion of sphingosine 1-phospahte (S1P) receptor-2 (S1P-2-) inhibits lung fibrosis through altering alveolar macrophage polarization and senescence in mice.(conference：BMB2015（第38回日本分子生物学会・第88回日本生化学会）)(2015/12/01)
- Sphingosine kinase-2 is required for autophagic lipid degradation in macrophage and inhibits atherosclerosis(2020/03/19)
- Regulation of intracellular clearance by 3'-phosphoinositide-specific phosphatase, myotubularin-relatedprotein-4 (MTMR4).(conference：第92回日本生化学会大会、横浜パシフィコ（横浜）)(2019/09/18)
- Class II phosphatidylinositol 3-kinase α and β isoforms are required for vascular smooth muscle Rho activation, contraction and blood pressure regulation in mice(conference：The 98th Annual Meeting of The Physiological Society of Japan)(2021/03/29)
- イノシトールリン脂質特異的3’-ホスファターゼMTMR4はリソソーム機能・オートファジーを制御する(conference：第94 回日本生理学会大会)(2017/03/28)
Others
- Sphingosine-1-phosphate signaling and biological activities in the cardiovascular system. Takuwa Y, Okamoto Y, Yoshioka K, Takuwa N. 1781 2008
- CALCIUM-DEPENDENT REGULATION OF RHO AND MYOSIN PHOSPHATASE IN VASCULAR SMOOTH MUSCLE Takuwa Y., Yoshioka K., Takuwa N., Wang Yu., Azam M.A., Sugimoto N. 16 2005
- Functions of Heteromeric Association Between Adenosine and P2Y Receptors. Nakata, H., Yoshioka, K., Kamiya, T., Tsuga, H., and Oyanagi, K. 26 2005
- ATP- and adenosine-Mediated Signaling in the Central Nervous System: Purinergic Receptor Complex: Generating Adenosine Nucleotide-Sensitive Adenosine Receptors. Yoshioka, K., Nakata, H. 94 2004
Arts and Fieldwork
Patent
Theme to the desired joint research
Grant-in-Aid for Scientific Research
○「2型PI3キナーゼα酵素による細胞内小胞輸送調節を介した物質・情報交換制御の機構」(2011-2013)
○「心血管ホメオスターシスとその破綻における機能性脂質の役割」(2009-2011)
○「KO マウスを用いたクラスⅡ型PI3 キナーゼC2α の血管形成における役割」(2008-2010)
○「がん血行転移を制御するシグナリング機構」(2007-)
○「伸展力を介した血管平滑筋トーヌスのカルシウム感受性制御」(2004-)
○「膜動現象を制御するイノシトールリン脂質脱リン酸化酵素の肺発達・成熟における役割」(2017-2019)
○「血管内皮機能に必須なPI(3)P代謝酵素によるメンブレン・トラフィック制御」(2014-2016)
Competitive research funding,Contribution
Collaborative research,Consignment study
Classes (Bachelors)
○Basic Human Physiology(2024)
○Organ Physiology 1(2024)
○Organ Physiology 2(2024)
○Organ Physiology(2024)
○Organ Physiology(2024)
○Organ Physiology(2024)
○Basic Health Science 2(2024)
○Organ Physiology(2024)
○Basic Health Science 1(2024)
○Organ Physiology(2018)
○Basic Health Science(2018)
○Basic Health Science(2017)
○Organ Physiology(2017)
○Basic Physiology(2016)
○Basic Health Science(2016)
○Basic Physiology(2015)
○Basic Physiology(2014)
○Basic Physiology(2013)
Classes (Graduate Schools)
○Human Body: Functions(2018)
○Signal Transduction in the Vascular System(2018)
○The Function of the Human Body(2018)
○The Function of the Human Body(2018)
○The Function of the Human Body(2017)
○Signal Transduction in the Vascular System(2017)
○Signal Transduction in the Vascular System(2017)
○Signal Transduction in the Vascular System(2016)
○Signal Transduction in the Vascular System(2016)
○The Function of the Human Body(2016)