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Researcher Information

last modified：2025/12/05

Associate Professor　SAKAI, Katsuya

Laboratory Website

Faculty, Affiliation

Cancer Research Institute

College and School Educational Field


Laboratory

Tumor dynamics and regulation　TEL:076-264-6747

Academic Background

Career

Kanazawa University(2020/09-)
Kanazawa University(2010/04-2020/09)
Osaka university(2008/04-2010/03)
Osaka university(2003/12-2008/03)
Bayer Yakuhin Co Ltd(1998/04-2003/12)

Year & Month of Birth

1973/07

Academic Society




Award




Specialities

Speciality Keywords

Receptor,Cancer,Chemical biology,Growth factor

Research Themes

Books

Papers

  • 　Histamine h(4) and h(2) receptors control histamine-induced interleukin-16 release from human CD8(+) T cells.　Florian Gantner,Katsuya Sakai,Michael W Tusche,William W Cruikshank,David M Center,Kevin B Bacon　The Journal of pharmacology and experimental therapeutics　303　1　300　2002/10
  • 　Discovery of novel and selective IKK-beta serine-threonine protein kinase inhibitors. Part 1.　Toshiki Murata,Mitsuyuki Shimada,Sachiko Sakakibara,Takashi Yoshino,Hiroshi Kadono,Tsutomu Masuda,Makoto Shimazaki,Takuya Shintani,Kinji Fuchikami,Katsuya Sakai,Hisayo Inbe,Keisuke Takeshita,Toshiro Niki,Masaomi Umeda,Kevin B Bacon,Karl B Ziegelbauer,Timothy B Lowinger　Bioorganic & medicinal chemistry letters　13　5　913　2003/03/10
  • 　CD40-dependent and -independent activation of human tonsil B cells by CpG oligodeoxynucleotides.　Florian Gantner,Patrice Hermann,Kosuke Nakashima,Satoko Matsukawa,Katsuya Sakai,Kevin B Bacon　European journal of immunology　33　6　1576　2003/06
  • 　Alteration of cell adhesion and cell cycle properties of ES cells by an inducible dominant interfering Myb mutant　Naomi Iwai,Kenji Kitajima,Katsuya Sakai,Tohru Kimura,Toru Nakano　Oncogene　20　12　1425　2001/03　
  • 　Pleural mesothelioma instigates tumor-associated fibroblasts to promote progression via a malignant cytokine network.　Qi Li,Wei Wang,Tadaaki Yamada,Kunio Matsumoto,Katsuya Sakai,Yoshimi Bando,Hisanori Uehara,Yasuhiko Nishioka,Saburo Sone,Shotaro Iwakiri,Kazumi Itoi,Teruhiro Utsugi,Kazuo Yasumoto,Seiji Yano　The American journal of pathology　179　3　1483　2011/09

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  • 　3-D collagen-dependent cell surface expression of MT1-MMP and MMP-2 activation regardless of integrin beta 1 function and matrix stiffness　Katsuya Sakai,Takahiro Nakamura,Yoshinori Suzuki,Takafumi Imizu,Kunio Matsumoto　BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　412　1　98　2011/08
  • 　Met/HGF receptor activation is regulated by juxtamembrane Ser985 phosphorylation in hepatocytes.　Mizuho Nakayama,Katsuya Sakai,Atsuko Yamashita,Takahiro Nakamura,Yoshinori Suzuki,Kunio Matsumoto　Cytokine　62　3　446　2013/06
  • 　Intrinsic HGF Induced by Cancer Cells Promotes Lung Metastasis in Met-high Expressing Melanomas　Sato, Hiroki,Adachi, Eri,Sakai, Katsuya,Imamura, Ryu,Matsumoto, Kunio　CANCER SCIENCE　109　1023　2018/01
  • 　A selective novel low-molecular-weight inhibitor of IkappaB kinase-beta (IKK-beta) prevents pulmonary inflammation and shows broad anti-inflammatory activity.　Karl Ziegelbauer,Florian Gantner,Nicholas W Lukacs,Aaron Berlin,Kinji Fuchikami,Toshiro Niki,Katsuya Sakai,Hisayo Inbe,Keisuke Takeshita,Mina Ishimori,Hiroshi Komura,Toshiki Murata,Timothy Lowinger,Kevin B Bacon　British journal of pharmacology　145　2　178　2005/05
  • 　Suppression of fibrogenic gene expression and liver fibrosis using a synthetic prostacyclin agonist　Qing Xu,Katsuya Sakai,Mizuho Nakayama,Yoshinori Suzuki,Chikako Tambo,Yoshiki Sakai,Kunio Matsumoto　BIOMEDICAL RESEARCH-TOKYO　34　5　241　2013/10
  • 　Lower gefitinib dose led to earlier resistance acquisition before emergence of T790M mutation in epidermal growth factor receptor-mutated lung cancer model　Hiromi Hayakawa,Eiki Ichihara,Kadoaki Ohashi,Takashi Ninomiya,Masayuki Yasugi,Saburo Takata,Katsuya Sakai,Kunio Matsumoto,Nagio Takigawa,Mitsune Tanimoto,Katsuyuki Kiura　CANCER SCIENCE　104　11　1440　2013/11
  • 　Non-Small Cell Lung Cancer Cells Acquire Resistance to the ALK Inhibitor Alectinib by Activating Alternative Receptor Tyrosine Kinases.　Hideko Isozaki,Eiki Ichihara,Nagio Takigawa,Kadoaki Ohashi,Nobuaki Ochi,Masayuki Yasugi,Takashi Ninomiya,Hiromichi Yamane,Katsuyuki Hotta,Katsuya Sakai,Kunio Matsumoto,Shinobu Hosokawa,Akihiro Bessho,Toshiaki Sendo,Mitsune Tanimoto,Katsuyuki Kiura　Cancer research　76　6　1506　2016/03/15
  • 　Artificial human Met agonists based on macrocycle scaffolds.　Kenichiro Ito,Katsuya Sakai,Yoshinori Suzuki,Naoya Ozawa,Tomohisa Hatta,Tohru Natsume,Kunio Matsumoto,Hiroaki Suga　Nature communications　6　6373　2015/03/11
  • 　Erratum: Discovery of novel and selective IKK-β serine-threonine protein kinase inhibitors. Part 1 (Bioorganic and Medicinal Chemistry Letters (2003) 13 (913) PII: S0960894X02010466)　Toshiki Murata,Mitsuyuki Shimada,Sachiko Sakakibara,Takashi Yoshino,Kiroshi Kadono,Tsutomu Masuda,Makoto Shimazaki,Takuya Shintani,Kinji Fuchikami,Katsuya Sakai,Hisayo Inbe,Keisuke Takeshita,Toshiro Niki,Masaomi Umeda,Kevin B. Bacon,Karl B. Ziegelbauer,Timothy B. Lowinger　Bioorganic and Medicinal Chemistry Letters　13　20　3627　2003/10/20
  • 　Angioinhibitory Action of NK4 Involves Impaired Extracellular Assembly of Fibronectin Mediated by Perlecan-NK4 Association　Katsuya Sakai,Takahiro Nakamura,Kunio Matsumoto,Toshikazu Nakamura　JOURNAL OF BIOLOGICAL CHEMISTRY　284　33　22491　2009/08
  • 　HGF-Met Pathway in Regeneration and Drug Discovery.　Kunio Matsumoto,Hiroshi Funakoshi,Hisaaki Takahashi,Katsuya Sakai　Biomedicines　2　4　275　2014/10/31
  • 　Oral administration of a novel long-acting prostacyclin agonist with thromboxane synthase inhibitory activity for pulmonary arterial hypertension.　Atsuhiro Nakamura,Noritoshi Nagaya,Hiroaki Obata,Katsuya Sakai,Yoshiki Sakai,Masanori Yoshikawa,Kaoru Hamada,Kunio Matsumoto,Hiroshi Kimura　Circulation journal : official journal of the Japanese Circulation Society　77　8　2127　2013
  • 　Critical role of histamine H4 receptor in leukotriene B4 production and mast cell-dependent neutrophil recruitment induced by zymosan in vivo.　Keisuke Takeshita,Katsuya Sakai,Kevin B Bacon,Florian Gantner　The Journal of pharmacology and experimental therapeutics　307　3　1072　2003/12
  • 　Anti-cancer approach with NK4: Bivalent action and mechanisms.　Takahiro Nakamura,Katsuya Sakai,Toshikazu Nakamura,Kunio Matsumoto　Anti-cancer agents in medicinal chemistry　10　1　36　2010/01
  • 　Different growth and metastatic phenotypes associated with a cell-intrinsic change of Met in metastatic melanoma.　Eri Adachi,Katsuya Sakai,Takumi Nishiuchi,Ryu Imamura,Hiroki Sato,Kunio Matsumoto　Oncotarget　7　43　70779　2016/10/25
  • 　HGF-Antagonists: Structure, Activities, and Anti-cancer Approach　Katsuya Sakai,Takahiro Nakamura,Takayoshi Kinoshita,Toshikazu Nakamura,Kunio Matsumoto　CURRENT SIGNAL TRANSDUCTION THERAPY　6　2　191　2011/05
  • 　Hepatocyte growth factor and Met in tumor biology and therapeutic approach with NK4.　Kunio Matsumoto,Takahiro Nakamura,Katsuya Sakai,Toshikazu Nakamura　Proteomics　8　16　3360　2008/08
  • 　Suppression of acute hepatic injury by a synthetic prostacyclin agonist through hepatocyte growth factor expression　Qing Xu,Mizuho Nakayama,Yoshinori Suzuki,Katsuya Sakai,Takahiro Nakamura,Yoshiki Sakai,Kunio Matsumoto　AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY　302　4　G420　2012/02
  • 　Inhibition of transforming growth factor-β signaling potentiates tumor cell invasion into collagen matrix induced by fibroblast-derived hepatocyte growth factor.　Jun Oyanagi,Nako Kojima,Haruki Sato,Shouichi Higashi,Keiji Kikuchi,Katsuya Sakai,Kunio Matsumoto,Kaoru Miyazaki　Experimental cell research　326　2　267　2014/08/15
  • 　Hepatocyte growth factor and Met in drug discovery　Katsuya Sakai,Shunsuke Aoki,Kunio Matsumoto　JOURNAL OF BIOCHEMISTRY　157　5　271　2015/05
  • 　Lower gefitinib dose led to earlier resistance acquisition before emergence of T790M mutation in epidermal growth factor receptor-mutated lung cancer model.　Hiromi Hayakawa,Eiki Ichihara,Kadoaki Ohashi,Takashi Ninomiya,Masayuki Yasugi,Saburo Takata,Katsuya Sakai,Kunio Matsumoto,Nagio Takigawa,Mitsune Tanimoto,Katsuyuki Kiura　Cancer science　104　11　1440　2013/11
  • 　Inhibition of Met/HGF receptor and angiogenesis by NK4 leads to suppression of tumor growth and migration in malignant pleural mesothelioma　Yoshinori Suzuki,Katsuya Sakai,Junko Ueki,Qing Xu,Takahiro Nakamura,Hideaki Shimada,Toshikazu Nakamura,Kunio Matsumoto　INTERNATIONAL JOURNAL OF CANCER　127　8　1948　2010/10
  • 　Hepatocyte growth factor twenty years on: Much more than a growth factor.　Takahiro Nakamura,Katsuya Sakai,Toshikazu Nakamura,Kunio Matsumoto　Journal of gastroenterology and hepatology　26 Suppl 1　188　2011/01
  • 　α-Lipoic acid-induced inhibition of proliferation and met phosphorylation in human non-small cell lung cancer cells.　Hiromitsu Michikoshi,Takahiro Nakamura,Katsuya Sakai,Yoshinori Suzuki,Eri Adachi,Seiichi Matsugo,Kunio Matsumoto　Cancer letters　335　2　472　2013/07/28
  • 　p27 Nuclear localization and growth arrest caused by perlecan knockdown in human endothelial cells　Katsuya Sakai,Kiyomasa Oka,Kunio Matsumoto,Toshikazu Nakamura　BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　392　3　403　2010/02
  • 　Cyclic Peptide-Based Biologics Regulating HGF-MET.　Hiroki Sato,Ryu Imamura,Hiroaki Suga,Kunio Matsumoto,Katsuya Sakai　International journal of molecular sciences　21　21　2020/10/27
  • 　Computer‐Assisted Identification of Inhibitor with Novel Pharmacophore Targeting First Kringle Domain of Hepatocyte Growth Factor　Junichi Taira,Miho Yamaguchi,Anju Tashiro,Asuka Kida,Ko Suzuki,Katsuya Sakai,Kunio Matsumoto,Shunsuke Aoki　ChemistrySelect　8　36　2023/09/21
  • 　Macrocyclic Peptide-Conjugated Tip for Fast and Selective Molecular Recognition Imaging by High-Speed Atomic Force Microscopy.　Leonardo Puppulin,Daiki Kanayama,Naohiro Terasaka,Katsuya Sakai,Noriyuki Kodera,Kenichi Umeda,Ayumi Sumino,Arin Marchesi,Wei Weilin,Hideo Tanaka,Takeshi Fukuma,Hiroaki Suga,Kunio Matsumoto,Mikihiro Shibata　ACS applied materials & interfaces　13　46　54817　2021/11/24　
  • 　De novo peptide grafting to a self-assembling nanocapsule yields a hepatocyte growth factor receptor agonist　Yamato Komatsu,Naohiro Terasaka,Katsuya Sakai,Emiko Mihara,Risa Wakabayashi,Kunio Matsumoto,Donald Hilvert,Junichi Takagi,Hiroaki Suga　iScience　24　11　103302　2021/11
  • 　Proteasomal degradation of polycomb-group protein CBX6 confers MMP-2 expression essential for mesothelioma invasion.　Katsuya Sakai,Takumi Nishiuchi,Shoichiro Tange,Yoshinori Suzuki,Seiji Yano,Minoru Terashima,Takeshi Suzuki,Kunio Matsumoto　Scientific reports　10　1　16678　2020/10/07
  • 　Impaired ligand-dependent MET activation caused by an extracellular SEMA domain missense mutation in lung cancer.　Wenyu Miao,Katsuya Sakai,Hiroki Sato,Ryu Imamura,Nawaphat Jangphattananont,Junichi Takagi,Michiru Nishita,Yasuhiro Minami,Kunio Matsumoto　Cancer science　110　10　3340　2019/10
  • 　Distinct Localization of Mature HGF from its Precursor Form in Developing and Repairing the Stomach.　Nawaphat Jangphattananont,Hiroki Sato,Ryu Imamura,Katsuya Sakai,Yumi Terakado,Kazuhiro Murakami,Nick Barker,Hiroko Oshima,Masanobu Oshima,Junichi Takagi,Yukinari Kato,Seiji Yano,Kunio Matsumoto　International journal of molecular sciences　20　12　2019/06/17
  • 　Macrocyclic peptide-based inhibition and imaging of hepatocyte growth factor.　Katsuya Sakai,Toby Passioura,Hiroki Sato,Kenichiro Ito,Hiroki Furuhashi,Masataka Umitsu,Junichi Takagi,Yukinari Kato,Hidefumi Mukai,Shota Warashina,Maki Zouda,Yasuyoshi Watanabe,Seiji Yano,Mikihiro Shibata,Hiroaki Suga,Kunio Matsumoto　Nature chemical biology　15　6　598　2019/06
  • 　Met receptor is essential for MAVS-mediated antiviral innate immunity in epithelial cells independent of its kinase activity.　Ryu Imamura,Hiroki Sato,Dominic Chih-Cheng Voon,Takayoshi Shirasaki,Masao Honda,Makoto Kurachi,Katsuya Sakai,Kunio Matsumoto　Proceedings of the National Academy of Sciences of the United States of America　120　40　e2307318120　2023/10/03
  • 　The constitutive high-affinity Met-binding site in the kringle domain is dispensable for the signalling activity of hepatocyte growth factor.　Masataka Umitsu,Katsuya Sakai,Keiko Tamura-Kawakami,Kunio Matsumoto,Junichi Takagi　Journal of biochemistry　167　6　577　2020/06/01
  • 　HGF conversion in bronchial epithelial cells triggers pre-metastatic niche formation in the lung　Hiroki Sato,Katsuya Sakai,Ryu Imamura,Kunio Matsumoto　CANCER SCIENCE　113　1142　2022/02
  • 　Cellular signaling and gene expression profiles evoked by a bivalent macrocyclic peptide that serves as an artificial MET receptor agonist.　Wenyu Miao,Katsuya Sakai,Naoya Ozawa,Takumi Nishiuchi,Yoshinori Suzuki,Kenichiro Ito,Tomomi Morioka,Masataka Umitsu,Junichi Takagi,Hiroaki Suga,Kunio Matsumoto　Scientific reports　8　1　16492　2018/11/07
  • 　A feedback loop between lamellipodial extension and HGF-ERK signaling specifies leader cells during collective cell migration.　Naoya Hino,Kimiya Matsuda,Yuya Jikko,Gembu Maryu,Katsuya Sakai,Ryu Imamura,Shinya Tsukiji,Kazuhiro Aoki,Kenta Terai,Tsuyoshi Hirashima,Xavier Trepat,Michiyuki Matsuda　Developmental cell　57　19　2290　2022/10/10
  • 　Macrocyclic peptide-based inhibition and imaging of hepatocyte growth factor　Sakai K,Passioura T,Sato H,Ito K,Furuhashi H,Umitsu M,Takagi J,Kato Y,Mukai H,Warashina S,Zouda M,Watanabe Y,Yano S,Shibata M,Suga H,Matsumoto K　Nature Chemical Biology　00　00　00　2019/05
  • 　HGF produced by smooth muscle cells promotes lung metastasis as a metastatic niche component　Sato, Hiroki,Sakai, Katsuya,Imamura, Ryu,Matsumoto, Kunio　CANCER SCIENCE　109　1161　2018/12
  • 　Lasso-grafting of macrocyclic peptide pharmacophores yields multi-functional proteins.　Emiko Mihara,Satoshi Watanabe,Nasir K Bashiruddin,Nozomi Nakamura,Kyoko Matoba,Yumi Sano,Rumit Maini,Yizhen Yin,Katsuya Sakai,Takao Arimori,Kunio Matsumoto,Hiroaki Suga,Junichi Takagi　Nature communications　12　1　1543　2021/03/09
  • 　Dimer Interface in Natural Variant NK1 Is Dispensable for HGF-Dependent Met Receptor Activation.　Yumiko Tahira,Katsuya Sakai,Hiroki Sato,Ryu Imamura,Kunio Matsumoto　International journal of molecular sciences　22　17　2021/08/26
  • 　Designing receptor agonists with enhanced pharmacokinetics by grafting macrocyclic peptides into fragment crystallizable regions.　Katsuya Sakai,Nozomi Sugano-Nakamura,Emiko Mihara,Nichole Marcela Rojas-Chaverra,Sayako Watanabe,Hiroki Sato,Ryu Imamura,Dominic Chih-Cheng Voon,Itsuki Sakai,Chihiro Yamasaki,Chise Tateno,Mikihiro Shibata,Hiroaki Suga,Junichi Takagi,Kunio Matsumoto　Nature biomedical engineering　7　2　164　2023/02
  • 　MET Activation by a Macrocyclic Peptide Agonist that Couples to Biological Responses Differently from HGF in a Context-Dependent Manner.　Wenyu Miao,Katsuya Sakai,Ryu Imamura,Kenichiro Ito,Hiroaki Suga,Tetsushi Sakuma,Takashi Yamamoto,Kunio Matsumoto　International journal of molecular sciences　19　10　2018/10/12
  • 　MET Enhances Amivantamab Binding to EGFR and Antibody-Dependent Cellular Toxicity.　Shigeki Sato,Neval Yilmaz,Sachiko Arai,Katsuya Sakai,Hiroki Sato,Yuya Murase,Tsukasa Ueda,Hayato Koba,Shigeki Nanjo,Yuichi Tambo,Hiroshi Kotani,Koji Fukuda,Hiroaki Taniguchi,Romain Amyot,Holger Flechsig,Hideko Isozaki,Kunio Matsumoto,Seiji Yano　Cancer science　2025/11/09
  • 　Complement component C4a binds to oxytocin and modulates plasma oxytocin concentrations and social behavior in male mice　Yasuhiko Yamamoto,Anpei Zhang,Teruko Yuhi,Ai Harashima,Anna A. Shabalova,Emina Nishizawa,Michiru Moriya,Seiichi Munesue,Yu Oshima,Maria Gerasimenko,Kazumi Furuhara,Chiharu Tsuji,Shigeru Yokoyama,Shinichi Horike,Jumpei Terakawa,Takiko Daikoku,Takumi Nishiuchi,Katsuya Sakai,Haruhiro Higashida　Biochemical and Biophysical Research Communications　152004　2025/05
  • 　A cyclic peptide-grafted Fc with hepatocyte growth factor functionality ameliorates hepatic fibrosis in a non-alcoholic steatohepatitis mouse model　Nichole Marcela Rojas-Chaverra,Ryu Imamura,Hiroki Sato,Toby Passioura,Emiko Mihara,Tatsunori Nishimura,Junichi Takagi,Hiroaki Suga,Kunio Matsumoto,Katsuya Sakai　iScience　27　8　110426　2024/07
  • 　Identification of Novel Compounds That Bind to the HGF β-Chain In Silico, Verification by Molecular Mechanics and Quantum Mechanics, and Validation of Their HGF Inhibitory Activity In Vitro　Ko Suzuki,Keitaro Inoue,Ryota Namiguchi,Seiya Morita,Suzuho Hayakawa,Mikuri Yokota,Katsuya Saka,Kunio Matsumoto,Shunsuke Aoki　molecules　30　8　1801　2025/04
  • 　Cytokine Mimetics with Various Modalities　Katsuya Sakai,Hiroki Sato,Kunio Matsumoto　Israel Journal of Chemistry　2024/05/14
  • 　Condensation-dependent interactome of a chromatin remodeler underlies tumor suppressor activities.　Yasuhiro Tsukamoto,Atsuki Kawamura,Ayhan Yurtsever,Hidefumi Suzuki,Nichole Marcela Rojas-Chaverra,Hiroki Sato,Daisuke Ino,Takehiko Ichikawa,Weilin Wei,Shojiro Haji,Dominic Chih-Cheng Voon,Akinobu Matsumoto,Kunio Matsumoto,Hidehisa Takahashi,Noriyuki Kodera,Takeshi Fukuma,Yoshihiro Ogawa,Masaaki Nishiyama,Katsuya Sakai　Nature communications　16　1　9599　2025/10/30
  • 　Ligand Binding to the Membrane-Distal Domain of the Met Receptor Induces Dimerization at the Membrane-Proximal Domain.　Neval Yilmaz,Hiroki Tanino,Shun Sakuraba,Romain Amyot,Holger Flechsig,Atsushi Matsumoto,Hidetoshi Kono,Leonardo Puppulin,Mikihiro Shibata,Hiroshi Aoyama,Tsuyoshi Inoue,Kunio Matsumoto,Katsuya Sakai　ACS nano　2025/11/25
  • 　A cyclic peptide-grafted Fc with hepatocyte growth factor functionality ameliorates hepatic fibrosis in a non-alcoholic steatohepatitis mouse model 　Nichole Marcela Rojas-Chaverra, Ryu Imamura, Hiroki Sato, Toby Passioura, Emiko Mihara, Tatsunori Nishimura, Junichi Takagi, Hiroaki Suga, Kunio Matsumoto, Katsuya Sakai　iScience　2024/07
  • 　Cytokine Mimetics with Various Modalities 　Katsuya Sakai, Hiroki Sato, Kunio Matsumoto　Israel Journal of Chemistry　2024/05
  • 　Designing receptor agonists with enhanced pharmacokinetics by grafting macrocyclic peptides into fragment crystallizable regions 　Sakai K, Sugano-Nakamura N, Mihara E, Rojas-Chaverra NM, Watanabe S, Sato H, Imamura R, Voon DCC, Sakai I, Yamasaki C, Tateno C, Shibata M, Suga H, Takagi J, Matsumoto K　Nature Biomedical Engineering　2023
  • 　Met receptor is essential for MAVS-mediated antiviral innate immunity in epithelial cells independent of its kinase activity.　Imamura R, Sato H, Voon DCC, Shirasaki T, Honda M, Kurachi M, Sakai K, Matsumoto K.　Proc Natl Acad Sci U S A.　120　40　e2307318120　2023/09/25
  • 　Computer-Assisted Identification of Inhibitor with Novel Pharmacophore Targeting First Kringle Domain of Hepatocyte Growth Factor.　Taira J, Yamaguchi M, Tashiro A, Kida A, Suzuki K, Sakai K, Matsumoto K, Aoki S　ChemistrySelect　2023/09/21
  • 　A feedback loop between lamellipodial extension and HGF-ERK signaling specifies leader cells during collective cell migration.　2. Hino N, Matsuda K, Maryu G, Sakai K, Imamura R, Matsumoto K, Aoki K, Terai K, Hirashima T, Matsuda M.　Developmental Cell　57　17　2290-2304　2022
  • 　Dimer interface in natural variant NK1 is dispensable for HGF-dependent Met receptor activation.　Yumiko Tahira, Katsuya Sakai, Hiroki Sato, Ryu Imamura, and Kunio Matsumoto　International Journal of Molecular Sciences　22　9240　2021
  • 　Lasso-grafting of macrocyclic peptide pharmacophores yields multi-functional proteins.　Emiko Mihara, Satoshi Watanabe, Nasir K. Bashiruddin, Nozomi Nakamura, Kyoko matoba, Yumi Sano, Rumit Maini, Yizhen Yin, Katsuya Sakai, Takao Arimori, Kunio Matsumoto, Hiroaki Suga and Junichi Takagi　Nature Communications　12　1543　2021
  • 　De novo peptide grafting to a self-assembling nanocapsule yields a hepatocyte growth factor receptor agonist.　Komatsu, Y. Terasaka N, Sakai K, Mihara E, Wakabayashi R, Matsumoto K, Hilvert D, and Suga H. 　iScience　24　103302　2021
  • 　Peptide-Conjugated Tip for Fast and Selective Molecular Recognition Imaging by High-Speed Atomic Force Microscopy.　Puppulin L, Kanayama D, Terasaka, N, Sakai K, Kodera N, Umeda K, Sumino A, Marchesi A, Weilin W, Tanaka Hideo, Fukuma T, Suga H, Matsumoto K, and Shibata, M. 　ACS Appl. Mater. Interfaces 　13　54817–54829　2021
  • 　Proteasomal degradation of polycomb-group protein CBX6 confers MMP-2 expression essential for mesothelioma invasion.　2) Sakai K†, Nishiuci T, Tange S, Suzuki Y, Yano S, Terashima M, Suzuki T, Matsumoto K　Scientific Reports　10　16678　2020
  • 　Cyclic Peptide-Based Biologics Regulating HGF-MET. 　Hiroki Sato, Ryu Imamura, Hiroaki Suga, Kunio Matsumoto, and Katsuya Sakai　International Journal of Molecular Sciences 　21　7977　2020
  • 　Distinct Localization of Mature HGF from its Precursor Form in Developing and Repairing the Stomach. 　Jangphattananont N, Sato H, Imamura R, Sakai K, Terakado Y, Murakami K, Barker N, Oshima H, Oshima M, Takagi J, Kato Y, Yano S, Matsumoto K.　International Journal of Molecular Sciences 　20　2019
  • 　Macrocyclic peptide-based inhibition and imaging of hepatocyte growth factor.　Sakai K, Passioura T, Sato H, Ito K, Furuhashi H, Umitsu M, Takagi J, Kato Y, Mukai H, Warashina S, Zouda M, Watanabe Y, Yano S, Shibata M, Suga H, Matsumoto K.　Nature Chemical Biology　2019
  • 　The constitutive high affinity Met binding site in the kringle domain is dispensable for the signaling activity of hepatocyte growth factor. 　Umitsu M, Sakai K, Tamura-Kawakami K, Matsumoto K, Takagi J.　Journal of Biochemistry　2019
  • 　Impaired ligand-dependent MET activation caused by an extracellular SEMA domain missense mutation in lung cancer. 　Miao W, Sakai K, Sato H, Imamura R, Jangphattananont N, Takagi J, Nishita M, Minami Y, Matsumoto K　Cancer Science 　110　3340-3349 　2019
  • 　Cellular signaling and gene expression profiles evoked by a bivalent macrocyclic peptide that serves as an artificial MET receptor agonist. 　Miao W, Sakai K, Ozawa N, Nishiuchi T, Suzuki Y, Ito K, Morioka T, Umitsu M, Takagi J, Suga H, Matsumoto K. 　Scientific Reports　8　16492　2018
  • 　MET activation by a macrocyclic peptide agonist that couples to biological responses differently from HGF in a context-dependent manner.　Miao W, Sakai K, Imamura R, Ito K, Suga H, Sakuma T, Yamamoto T, Matsumoto K.　International journal of molecular sciences　19　10　3141　2018
  • 　Probing conformational and functional states of human hepatocyte growth factor by a panel of monoclonal antibodies　Masataka Umitsu, Katsuya Sakai, Satoshi Ogasawara, Mika K. Kaneko, Ryoko Asaki, Keiko Tamura-Kawakami, Yukinari Kato, Kunio Matsumoto & Junichi Takagi　Scientific Reports　6　2016
  • 　Different growth and metastatic phenotypes associated with a cell-intrinsic change of Met in metastatic melanoma　Adachi E, Sakai K, Nishiuchi T, Imamura R, Sato H, Matsumoto K　Oncotarget　7　70779-70793　2016
  • 　Artificial human Met agonists based on macrocycle scaffolds.　Ito K, Sakai K, Suzuki Y, Ozawa N, Hatta T, Natsume T, Matsumoto K, and Suga H　Nature Communications　6　2015
  • 　Hepatocyte growth factor and Met in drug discovery.　Sakai K, Aoki S, and Matsumoto K　Journal od Biochemistry　157　271-284　2015
  • 　HGF-Met Pathway in Regeneration and Drug Discovery.　Matsumoto K, Funakoshi H, Takahashi H, and Sakai K　Biomedicines　2　275-300　2014
  • 　Inhibition of transforming growth factor-β signaling potentiates tumor cell invasion into collagen matrix induced by fibroblast-derived hepatocyte growth factor.　Oyanagi J, Kojima N, Sato H, Higashi S, Kikuchi K, Sakai K, Matsumoto K, and Miyazaki K　Experimental Cell Research　326　267-279　2014
  • 　Suppression of fibrogenic gene expression and liver fibrosis using a synthetic prostacyclin agonist.　7. Xu Q, Sakai K, Nakayama M, Suzuki Y, Tambo C, Sakai Y, and Matsumoto K　Biomedical research　34　241-250　2013
  • 　Lower gefitinib dose led to earlier resistance acquisition before emergence of T790M mutation in EGFR mutated lung cancer model.　Hayakawa H, Ichihara E, Ninomiya T, Takata S, Ohashi K, Masayuki Yasugi, Sakai K, Matsumoto K, Takigawa N, Tanimoto M, and Kiura K. 　Cancer Science　104　1440-1446　2013
  • 　HGF-Antagonists: Structure, Activities, and Anti-cancer Approach　Sakai, Katsuya;Nakamura, Takahiro;Kinoshita, Takayoshi;Nakamura, Toshikazu;Matsumoto, Kunio　CURRENT SIGNAL TRANSDUCTION THERAPY　6　2　191-199　2011
  • 　Hepatocyte growth factor twenty years on: Much more than a growth factor　Nakamura, Takahiro;Sakai, Katsuya;Nakamura, Toshikazu;Matsumoto, Kunio　JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY　26　0　188-202　2011
  • 　α-Lipoic acid-induced inhibition of proliferation and met phosphorylation in human non-small cell lung cancer cells.　CANCER LETTERS　335　2　472-478　2013/07
  • 　Oral Administration of a Novel Long-Acting Prostacyclin Agonist With Thromboxane Synthase Inhibitory Activity for Pulmonary Arterial Hypertension.　77　2127-2133　2013/05
  • 　Met/HGF receptor activation is regulated by juxtamembrane Ser985　phosphorylation in hepatocytes.　CYTOKINE　62　446-452　2013/04
  • 　Suppression of acute hepatic injury by a synthetic prostacyclin agonist through hepatocyte growth factor expression.　AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY　302　420-429　2012/02
  • 　Pleural Mesothelioma Instigates Tumor-associated Fibroblasts to Promote Progression via a Malignant Cytokine Network.　i Li, Wei Wang, Tadaaki Yamada, Kunio Matsumoto, Katsuya Sakai, Yoshimi Bando, Hisanori Uehara, Yasuhiko Nishioka, Saburo Sone, Shotaro Iwakiri, Kazumi Itoi, Teruhiro Utsugi, Kazuo Yasumoto, Seiji Yano　AMERICAN JOURNAL OF PATHOLOGY　179　3　1483-1493　2011/09
  • 　p27 nuclear localization and growth arrest caused by perlecan knockdown in human endothelial cells.　 Katsuya Sakai, Kiyomasa Oka, Kunio Matsumoto, Toshikazu Nakamura　BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　392　3　403-408　2010/02
  • 　Anti-Cancer approach with NK4: Bivalent action and mechanisms. 　Takahiro Nakamura, Katsuya Sakai, Toshikazu Nakamura, Kunio Matsumoto.　Anti-Cancer Agents in Medicinal Chemistry　10　1　36-46　2010/01
  • 　Inhibition of Met/HGF receptor and angiogenesis by NK4 Leads to suppression of tumor growth and migration in malignant pleural mesothelioma.　Yoshinori Suzuki, Katsuya Sakai, Junko Ueki, Qing Xu, Takahiro Nakamura, Shimada H, Toshikazu Nakamura, Kunio Matsumoto　INTERNATIONAL JOURNAL OF CANCER　127　8　1948-1957　2010/10
  • 　Hepatocyte growth factor twenty years on: much more than a growth factor　Takahiro Nakamura, Katsuya Sakai, Toshikazu Nakamura, Kunio Matsumoto.　JOURNAL OF GASTROENTEROLOGY AND HEPATOLOGY　suppl 1　188-202　2011/01
  • 　HGF-Antagonists: Structure, Activities, and Anti-cancer Approach.　Katsuya Sakai, Takahiro Nakamura, Takayoshi Kinoshita, Toshikazu Nakamura, Kunio Matsumoto　Current Signal Transduction Therapy　6　2　191-199　2011/05
  • 　3-D collagen-dependent cell surface expression of MT1-MMP and MMP-2 activation regardless of integrin β1 function and matrix stiffness　Katsuya Sakai, Takahiro Nakamura, Yoshinori Suzuki, Takafumi Imizu, and Kunio Matsumoto　BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS　412　1　98-103　2011/08

Conference Presentations

  • MET受容体の人為制御と活性化の構造基盤(2020/09/15)
  • Peptide-grafted Proteins and Nanometorology for Targeting and Understanding of Growth Factor Receptor(conference：1st WPI NanoLSI-iCeMS Joint Symposium)(2020/01/23)
  • HGF/MET receptor: Approaches using macrocyclic peptides and atomic force microscopy(2019/09/27)
  • Artificial Met receptor agonist based on nonstandard cyclic peptides

Others

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「３－Ｄ上皮細胞組織化モデルにおける動的細胞分化転換と形態制御の研究」(2011-2012)　

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

Classes (Graduate Schools)

○Tumor Biology(2017)
○Tumor Biology(2017)
○Seminar on Tumor Biology(2016)
○Tumor Biology(2016)
○Tumor Biology(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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