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Researcher Information

last modified:2019/09/26

Associate Professor NAKAGAWA-GOTO Kyoko

Laboratory Website
Laboratory Website

Faculty, Affiliation

Faculty of Pharmacy, Institute of Medical, Pharmaceutical and Health Sciences

College and School Educational Field

Graduate School of Natural Science and Technology
School of Pharmaceutical Sciences, College of Medical, Pharmaceutical and Health Sciences
School of Pharmacy, College of Medical, Pharmaceutical and Health Sciences

Laboratory

Molecular Pharmacognosy TEL:076-264-6305

Academic Background

【Academic background(Bachelor's Degree)】
Kanazawa University
【Degree】
Ph.D.

Career

University of North Carolina at Chapel Hill Eshelman School of Pharmacy Adjuct Associate Professor(2012/04/01-)
The University of North Carolina at Chapel Hill School of Pharmacy Research Associate Professor, (2011/03/01-2012/03/31)
The University of North Carolina at Chapel Hill School of Pharmacy Research Assistant Professor(2006/08/01-2011/02/28)
Post-doctoral Research Associate, The University of North Carolina at Chapel Hill School of Pharmacy(2002/07/01-2006/07/31)
Post-doctoral Research Associate, The University of North Carolina at Chapel Hill Department of Chemistry(1998/10/01-2002/04/30)
Research Associate, Kanazawa University School of Pharmacy(1990/04/01-1998/09/30)
Research Assistant, Kanazawa University School of Pharmacy(1985/04/01-1990/03/31)
Visiting Scientist, The University of California at Berkeley  Department of Chemistry(1996/03/01-1996/07/31)

Year & Month of Birth

Academic Society



Award


○University Research Council Research Award (UNC)(2007/12/01)
○Uehara Foundation International Fellowship (1998/10/01)

Specialities

Drug development chemistry

Speciality Keywords

Medicinal Chemistry, Natural products, Organic Chemistry, Chemical Biology

Research Themes

Discovery and development of drug candidates based on bioactive natural products

Books

Papers

  •  Prenylated acetophloroglucinol dimers from Acronychia trifoliolata: Structure elucidation and total synthesis Miyake K, Morita C, Suzuki A, Matsushita N, Saito Y, Goto M, Newman DJ, O’Keefe BR, Lee KH, Nakagawa-Goto K Journal of Natural Products ASAP 2019/09/24
  •  Spiro[3.5]nonenyl meroterpenoid lactones, cryptolaevilactones G–L, an ionone derivative and total synthesis of cryptolaevilactone M from Cryptocarya laevigata Tsurumi F, Yuta Miura, Nakano M, Saito Y, Fukuyoshi S, Newman DJ, O’Keefe BR, Lee KH, Nakagawa-Goto K. Journal of Natural Products 2019/08/23
  •  Synthesis of 4-epi-Parviflorons A, C and E: Structure-Activity Relationship Study of Antiproliferative Abietane Derivatives Miyajima Y, Takeya M, Saito Y, Goto M, Nakagawa-Goto K Journal of Organic Chemistry 84 3239 2019/02/22
  •  Synthesis of 1-methoxyindoles and related analogs of pimprinine, (±)-chelonin A and B, based on 1-hydroxyindole chemistry Aoki K, Nagahama Y, Sugaya K, Maeda Y, Sato H, Nakagawa(Goto) K, Somei M Heterocycles 98 236-270 2019/02/13
  •  Anti-proliferative and chemosensitizing effects of diarylheptanoids on human tumor cell lines Miyagishi S, Saito Y, Goto M, Nakagawa-Goto K ACS Omega 4 2053–2062 2019/01/26

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  •  Coffee diterpenes kahweol acetate and cafestol synergistically inhibit the proliferation and migration of prostate cancer cells Iwamoto H, Izumi K, Netsagdorj A, Naito R, Makino T, Kadomoto S, Hiratsuka K, Shigehara K, Kadono Y, Narimoto K, Saito Y, Nakagawa-Goto K, Mizokami A. The Prostate 1–12 2018/12/19
  •  5’-Chloro-2,2’-dihydroxychalcone and Related Flavanoids as Treatments for Prostate Cancer Saito Y, Mizokami A, Tsurimoto H, Izumi K, Goto M, Nakagawa-Goto K. European Journal of Medicinal Chemistry 157 1143-1152 2018/08/28
  •  Corymbulosins I–W, Cytotoxic clerodane diterpenes from the bark of Laetia corymbulosa Aimaiti S, Suzuki A, Saito Y, Fukuyoshi S, Goto M, Miyake K, Newman DJ, O’Keefe BR, Lee KH, Nakagawa-Goto K. Journal of Organic Chemistry 83 951 951 2018/01/01
  •  Antiproliferative alkaloids from Alangium longiflorum, an endangered tropical plant species Takeuchi M, Saito Y, Goto M, Miyake K, Newman DJ, O’Keefe BR, Lee KH, Nakagawa-Goto K Journal of Natural Products 81 1884-1891 2018/08/14
  •  Phytoagent Deoxyelephantopin and Its Derivative Inhibit Triple Negative Breast Cancer Cell Activity through ROS-Mediated Exosomal Activity and Protein Functions 12. Shiau JY, Chang YQ, Nakagawa-Goto K, Lee KH, Shyur LF Frontiers in Pharmacology 8 1-15 2017/06/04
  •  Kleinhospitine E and cycloartane triterpenoids from Kleinhovia hospita L. Rahim A, Saito Y, Miyake K, Goto M, Chen CH, Alam G, Morris-Natchke S, Lee KH, Nakagawa-Goto K. Journal of Natural Products 81 1619–1627 2018/07/17
  •  Antitubulin effects of aminobenzothiophene-substituted triethylated chromones Kobayashi Y, Saito Y, Goto M, Nakagawa-Goto K BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 2017/04/17
  •  Secondary metabolites, monoterpene-polyketides containing a spiro[3.5]nonane from Cryptocarya laevigata, Tsurumi F, Miura Y, Saito Y, Miyake K, Fujie T, Newman DJ, O’Keefe BR, Lee KH, Nakagawa-Goto K, Organic Letters 20 2282–2286 2018/04/03
  •  Phytoagent deoxyelephantopin derivative inhibits triple negative breast cancer cell activity by inducing oxidative stress-mediated paraptosis-like cell death Shiau JY, Nakagawa-Goto K, Lee KH, Shyur LF Oncotarget 2017/04/19
  •  Corymbulosins D–H, 2-Hydroxy- and 2-Oxo-clerodane Diterpenes from the Bark of Laetia corymbulosa  Suzuki A, Saito Y, Fukuyoshi S, Goto M, Miyake K, Newman DJ, O’Keefe BR, Lee KH, Nakagawa-Goto K. JOURNAL OF NATURAL PRODUCTS 80 1065-1072 2017/03/14
  •  Total synthesis of antiproliferative parviflorone F Saito Y, Goto M, Nakagawa-Goto K Organic Letters 20 628 2018/01/18
  •  (-)-Neocaryachine, an antiproliferative pavine alkaloid from Cryptocarya laevigata induces DNA double-strand breaks. Suzuki Y, Saito Y, Goto M, Newman D, O'Keefe B, Lee KH, Nakagawa-Goto K JOUNAL OF NATURAL PRODUCTS 80 220 2017/01/15
  •  A Novel Clerodane Diterpene from Vitex cofassus Rasyid FA, Fukuyoshi S, Ando H, Miyake K, Atsumi T, Fujie T, Saito Y, Goto M, Shinya T, Mikage M, Sasaki, Nakagawa-Gotoa K. CHEMICAL AND PHARMACEUTICAL BULLETIN 65 116–120 2016/10/30
  •  Phenylethylchromones with in vitro antitumor promoting activity from Aquilaria filarial Suzuki A, Miyake K, Saito Y, Faradiba, Tokuda H, Takeuchi M, Suzuki N, Ichiishi E, Fujie T, Goto M, Sasaki S, Nakagawa-Goto K Planta Medica 83 300 2016/06/16
  •  Total synthesis and in vitro anti tumor-promoting activity of racemic acetophenone monomers from Acronychia trifoliolata Morita C, Kobayashi Y, Tokuda H, Saito Y, Miyake M, Suzuki N, Ichiishi E, Lee KH, Nakagawa-Goto K JOURNAL OF NATURAL PRODUCTS 79 2890–2897 2016/10/26
  •  Acetophenone monomers from Acronychia trifoliolata Miyake M, Suzuki A, Morita C, Goto M, Newman DJ, O’Keefe B, Morris-Natschke SL, Lee KH, Nakagawa-Goto K JOURNAL OF NATURAL PRODUCTS 79 2883–2889 2016/10/14
  •  Triethylated chromones with substituted naphthalenes as novel tubulin inhibitors Nakagawa-Goto K, Taniguchi Y, Watanabe Y, Oda A, Ohkoshi E, Hamel E, Lee KH, Goto M BIOORGANIC MEDICINAL CHEMISTRY 24 6048–6057 2016/10/02
  •  Novel sesquiterpene lactone analogues as potent anti-breast cancer agents Nakagawa-Goto K, Chen JY, Cheng YT, Lee WL, Takeya M, Saito Y, Lee KH, Shyur LF Mol. Oncol. 10 921–937 2016
  •  A novel plant sesquiterpene lactone derivative DETD-35 suppresses BRAFV600E mutant melanoma growth and overcomes acquired vemurafenib resistance in mice Feng JH, Nakagawa-Goto K, Lee KH, Shyur LF. Mol. Cancer Ther. 15 1163–1176 2016
  •  Development of a novel class of tubulin inhibitor from desmosdumotin B with a hydroxylated bicyclic B-ring Nakagawa-Goto K,* Oda A, Hamel E, Ohkoshi E, Bastow KF, Lee KH, Goto M.* JOURNAL OF MEDICINAL CHEMISTRY 2015
  •   A-ring modified betulinic acid derivatives as cancer preventive agents. Hung HY, Nakagawa-Goto K, Tokuda H, Iida A, Suzuki N, Qian K, Lee KH BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 24 3 1005 2014/01
  •  Isolation, Structure Determination, and Anti-HIV Evaluation of Tigliane-Type Diterpenes and Biflavonoid from Stellera chamaejasme 1. Asada Y, Sukemori A, Watanabe T, Malla K, Yoshikawa T, Li Wei, Kuang X, Koike K, Chen CH, Akiyama T, Qian K, Nagakawa-Goto K, Morris-Natschke S, Lu Y, Lee KH. JOURNAL OF NATURAL PRODUCTS 76 5 852 2013/05
  •  1-(3,4,5-Trimethoxyphenyl)ethane-1,2-diyl esters, a novel compound class with potent chemoreversal activity Hung HY, Ohkoshi E, Goto M, Nakagawa-Goto K, Lee KH.  BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 22 24 7726 2012/10
  •  Antitumor Agents 293. Non-toxic Dimethyl-4,4′-dimethoxy-5,6,5′,6′-dimethylenedioxybiphenyl-2,2′-dicarboxylate (DDB) Analogs Chemosensitize Multidrug Resistant Cancer Cells to Clinical Anticancer Drugs Hung HY, Ohkoshi E, Goto M, Bastow KF, Nakagawa-Goto K, Lee KH JOURNAL OF MEDICINAL CHEMISTRY 2012/05
  •  Design and synthesis of gambogic acid analogs as potent cytotoxic and anti-inflammatory agents.  Yen CT, Nakagawa-Goto K, Hwang TL, Morris-Natschke SL, Bastow KF, Wu YC, Lee KH BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 22 4018 2012/04
  •  Antitumor agents 289. Design, Synthesis, and In Vivo Anti-Brest Cancer Activity of 4-Amino-2H-benzo[h]chromen-2-one Analogs (ABO) and 4-Amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one Analogs (ATBO) with Improved Water Solubility Dong Y, Nakagawa-Goto K, Lai CY, Morris-Natschke SL, Bastow KF, Lee KH JOURNAL OF NATURAL PRODUCTS 75 370 2012/02
  •  Antitumor Agents 291 Expanded B-Ring Modification Study of 6,8,8-Triethyl Desmosdumotin B Analogues as Multidrug-Resistance Selective Agents Nakagawa-Goto K, Bastow KF, Ohkoshi E, Morris-Natschke SL, Lee KH Med. Chem.(Open access journal) 2011/12
  •  Stelleralides A-C, Novel Potent Anti-HIV Daphnane-Type Diterprnoids from Stellera Chamaejaseme Asada Y, Sukemori A, Watanabe T, Malla KJ, Yoshikawa T, Li W, Koike K, Chen CH, Akiyama T, Qian K, Nakagawa-Goto K, Morris-Natschke SL, Lee KH ORGANIC LETTERS 13 2904 2011/05
  •  Antitumor agents 287. Substituted 4-Amino-2H-pyran -2-one Analogs (APO) Reveal a New Scaffold from Neo-tanshinlactone with In Vitro Anticancer Activity Dong Y, Nakagawa-Goto K, Lai CY, Morris-Natschke SL, Bastow KF, Lee KH BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 21 2341 2011/03
  •  A unique P-glycoprotein interacting agent displays anticancer activity against hepatocellular carcinoma through inhibition of GRP78 and mTOR pathways Kuo TC, Chiang PC, Yu CC, Nakagawa-Goto K, Bastow KF, Lee KH, Guh JH BIOCHEMICAL PHARMACOLOGY 81 1136 2011/03
  •  Antitumor Agents 283. Synthesis and Biological Evaluation of Desmosdumotin C Analogs as Potent Antitumor Agents Nakagawa-Goto K,* Wu PC, Bastow KF, Chen HY, Lin JC, Wen H, Yang J, Goto M, Morris-Natschke SL, Yang PC, Lee KH BIOORGANIC & MEDICINAL CHEMISTRY 19 1816 2011/01
  •  Synthetic Approaches to the Bottom Half Fragment for Bryostatin 11 Nakagawa-Goto K, Crimmins MT SYNLETT 11 1555 2011/02
  •  Formal Synthesis of the Bryostatin Northern Hemisphere: Asymmetric Synthesis of the B-ring and C(1)-C(9) Fragment Nakagawa-Goto K, Crimmins MT SYNLETT 10 1413 2011/01
  •  Toward the Total Synthesis of Bryostatin 11: Stereoselective Construction of the C13-Exocyclic Enoate in the C1-C16 Fragment Nakagawa-Goto K, Crimmins MT SYNTHETIC COMMUNICATIONS 41 3032 2011/06
  •  Antitumor Agents 284. A New Desmosdumotin B Analogue with Bicyclic B-ring as Cytotoxic and Antitubulin Agent Nakagawa-Goto K,* Wu PC, Lai CY, Hamel E, Zhu H, Zhang L, Kozaka T, Ohkoshi E, Goto M, Bastow KF, Lee KH JOURNAL OF MEDICINAL CHEMISTRY 54 1244 2011/02
  •  Antitumor agents 279. Structure-Activity Relationship and In Vivo Studies of Novel 2-(Furan-2-yl)naphthalen-1-ol (FNO) Analgos as Potent and Selective Anti-Breast Cancer Agents Dong Y, Nakagawa-Goto K, Lai CY, Kim Y, Morris-Natschke SL, Lee EYHP, Bastow KF, Lee KH BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 21 52 2011/01
  •  Antitumor agents 281.Design, Synthesis, and Biological Activity of Substituted 4-Amino-7,8,9,10-tetrahydro-2H-benzo[h]chromen-2-one Analogs (ATBO) as In Vitro Anticancer Agents Dong Y, Nakagawa-Goto K, Lai CY, Morris-Natschke SL, Bastow KF, Lee KH BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 21 546 2011/01
  •  Antitumor Agents 282. 2’-(R)-O-Acetylglaucarubinone, a Novel Quassinoid from Odyendyea gabonensis as a Potent Anti-breast and Anti-ovarian Cancer Agent Usami Y, Nakagawa-Goto K, Lang JY, Kim Y, Lai CY, Goto M, Sakurai N, Taniguchi M, Akiyama T, Morris-Natsucke SL, Bastow KF, Cragg G, Newman DJ, Fujitake M, Takeya K, Hung MC, Lee EYH P, Lee KH JOURNAL OF NATURAL PRODUCTS 73 1553 2010/08
  •  Antitumor Agents 280. MDR-Selective Desmosdumotin B Analogues Nakagawa-Goto K,* Chang PC, Lai CY, Hung HY, Chen TH, Wu PC, Zhu H, Sedykh A, Bastow KF, Lee KH JOURNAL OF MEDICINAL CHEMISTRY 53 6699 2010/08
  •  Antitumor agents 278. 4-Amino-2H-benzo[h]chromen-2-one (ABO) analogs as potent in vitro anti-cancer agents Dong Y, Nakagawa-Goto K, Lai CY, Morris-Natschke SL, Bastow KF, Lee KH BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 20 4085 2010/05
  •  Antitumor agents 273. Design and synthesis of N-alkyl-thiocolchicinoids as potential antitumor agents Kozaka T, Nakagawa-Goto K, Shi Q, Lai CY, Hamel E, Bastow KF, Brossi A, Lee KH BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 20 4091 2010/05
  •  Cancer Preventive Agents 10. Chemopreventive Potential of Dehydrozingerone Analogs Tatsuzaki J, Nakagawa-Goto K, Tokuda H, Lee KH JOURNAL OF ASIAN NATURAL PRODUCTS RESEARCH 12 227 2010/03
  •  Antitumor Agents. 272. Structure−Activity Relationships and In Vivo Selective Anti-Breast Cancer Activity of Novel Neo-tanshinlactone Analogues.  Dong Y, Shi Q, Pai HC, Peng CY, Pan SL, Teng CM, Nakagawa-Goto K, Yu D, Liu YN, Wu PC, Bastow KF, Morris-Natschke SL, Brossi A, Lang JY, Hsu JL, Hung MC, Lee EYHP, Lee KH JOURNAL OF MEDICINAL CHEMISTRY 53 2299 2010/02
  •  Antitumor Agents 271. Total Synthesis and Evaluation of Brazilein and Analogs as Anti-inflammatory and Cytotoxic Agents Yen CT, Nakagawa-Goto K, Hwang TL, Wu PC, Morris-Natschke SL, Lai WC, Bastow KF, Chang FR, Wu YC, Lee KH BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 20 1037 2010/01
  •  Antitumor Agents 270. Novel Substituted 6-Phenyl-4H-furo[3,2-c]pyran-4-one Derivatives as Potent and Highly Selective Anti-Breast Cancer Agents Dong Y, Shi Q, Nakagawa-Goto K, Wu PC, Morris-Natschke SL, Brossi A, Bastow KF, Lang JY, Hung MC, Lee KH BIOORGANIC & MEDICINAL CHEMISTRY 18 803 2010/01
  •  Antitumor Agents 269. Non-aromatic ring-A neotanshinlactone analog, TNO, as a new class of potent antitumor agents Dong Y, Shi Q, Nakagawa-Goto K, Wu PC, Bastow KF, Morris-Natschke SL, Lee KH BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 19 6289 2009/09
  •  Cancer Preventive Agents 9. Cancer Chemopreventive Effects of Betulinic Acid Derivastives Nakagawa-Goto K, Yamada K, Tokuda H, Lee KH BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 19 3378 2009/05
  •  Cytotoxic calanquinone A from Calanthe arisanensis and its first total synthesis Lee CL, Nakagawa-Goto K, Yu D, Liu YN, Bastow KF, Morris-Natschke SL, Chang FR, Wu YC, Lee KH BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 18 4275 2008/07
  •  Antitumor Agents 260. New Desmosdumotin B Analogs with Improved Anticancer Activity Nakagawa-Goto K, Bastow KF, Chen TH, Morris-Natschke SL, Lee KH JOURNAL OF MEDICINAL CHEMISTRY 51 3297 2008/05
  •  Cancer Preventive Agents. 7. Antitumor-Promoting Effects of Seven Active Flavonolignans from Milk Thistle (Silybum marianumI) on Epstein-Barr Virus Activation Lin AS, Shibano M, Nakagawa-Goto K, Tokuda H, Itokawa H, Morris-Natschke SL, Lee KH PHARMACEUTICAL BIOLOGY 45 10 735 2007/07
  •  Anti-AIDS agents 73: Structure-activity relationship study and asymmetric synthesis of 3-O-monomethylsuccinyl-betulinic acid derivatives Qian K, Nakagawa-Goto K, Yu D, Morris-Natschke SL, Theodore NJ, Kilgore N, Allaway GP, Lee KH BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 17 6553 2007/09
  •  Antitumor Agents 258. Syntheses and Evaluation of Dietary Antioxidant Taxoid Conjugates as Novel Cytotoxic Agents Nakagawa-Goto K, Yamada K, Nakamura S, Chen TH, Bastow KF, Wang SC, Hung MC, Lee FY, Lee FC, Lee KH BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 17 5204 2007/07
  •  First Total Synthesis of Protoapigenone and its Analogs as Potent Cytotoxic Agents Lin AS, Nakagawa-Goto K, Chang FR, Yu D, Morris-Natschke SL, Wu CC, Chen SL, Wu YC, Lee KH JOURNAL OF MEDICINAL CHEMISTRY 50 3921 2007/07
  •  Antitumor Agents 255. Novel Glycyrrhetinic Acid-Dehydrozingerone Cinjugates as Cytotoxic Agents  Tatsuzaki J, Taniguchi M, Bastow KF, Nakagawa-Goto K, Morris-Natschke SL, Itokawa H, Baba K, Lee KH BIOORGANIC & MEDICINAL CHEMISTRY 15 6193 2007/06
  •  Antitumor Agents 253. Design, Synthesis, and Antitumor Evaluation of Novel 9-Substituted Phenanthrene-Based Tylophorine Derivatives as Potential Anticancer Agents Wei L, Shi Q, Bastow KF, Brossi A, Morris-Natschke SL, Nakagawa-Goto K, Wu TS, Pan SL, Teng CM, Lee KH JOURNAL OF MEDICINAL CHEMISTRY 50 3674 2007/06
  •  Antitumor Agents 259. Designs, Syntheses and Structure-Activity-Relationship Study of Desmosdumotin C Analogs Nakagawa-Goto K, Chen TH, Peng CY, Bastow KF, Wu JH, Lee KH JOURNAL OF MEDICINAL CHEMISTRY 50 3354 2007/06
  •  Antitumor Agents 256. Conjugation of Paclitaxel with Other Antitumor Agents: Evaluation of Novel Conjugates as Cytotoxic Agents Nakagawa-Goto K, Nakamura S, Bastow KF, Nyarko A, Peng CY, Lee FY, Lee FC, Lee KH BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 17 2894 2007/02
  •  Anti-HIV Agents 68: The First Total Synthesis of a Unique Potent Anti-HIV Chalcone from Genus Desmos Nakagawa-Goto K, Lee KH TETRAHEDRON LETTERS 47 8263 2006/09
  •  Dehydrozingerone, Chalcone, Isoeugenol Analogues as in vitro Anticancer Agents Tatsuzaki J, Bastow KF, Nakagawa-Goto K, Nakamura S, Itokawa H, Lee KH JOURNAL OF NATURAL PRODUCTS 69 1445 2006/09
  •  Antitumor Agents 254: Synthesis and Biological Evaluation of Novel Neo-tanshinlactone Analogs as Potent Anti-breast Cancer Agents Wang X, Nakagawa-Goto K, Bastow KF, Don MJ, Lin YL, Wu TS, Lee KH JOURNAL OF MEDICINAL CHEMISTRY 49 5631 2006/08
  •  Cancer Preventive Agents 5. Antitumor-Promoting Effects of Coumarins and Related Compounds on Epstein-Barr Virus Action and Two-Stage Mouse Skin Carcinogenesis, Suzuki M, Nakagawa-Goto K, Nakamura S, Tokuda H, Morris-Natschke SL, Kozuka M, Nishino H, Lee KH PHARMACEUTICAL BIOLOGY 44 178 2006/02
  •  Cytotoxic Alangium Alkaloids from Alangium longiflorum Sakurai N, Nakagawa-Goto K, Ito J, Sakurai Y, Nakanishi Y, Bastow KF, Cragg G, Lee KH PHYTOCHEMISTRY 67 894 2006/03
  •  Cancer Preventive Agents. Part 6: Chemopreventive Potential of Furanocoumarins and Related Compounds Wang X, Nakagawa-Goto K, Kozuka M, Tokuda H, Nishino H, Lee KH,  PHARMACEUTICAL BIOLOGY 44 116 2006/01
  •  First Total Synthesis of Desmosduotin C Nakagawa-Goto K, Lee KH SYNTHETIC COMMUNICATIONS 35 1735 2005/04
  •  Total Synthesis and Bioactivity of Unique Flavone Desmosdumotin B and Its Analogs Nakagawa-Goto K, Bastow KF, Wu JH, Lee KH BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 15 3016 2005/04
  •  Antitumor Agent 243. Syntheses and Cytotoxicity of Desmosdumotin C Derivatives Nakagawa-Goto K, Wu JH, Bastow KF, Wu CC, Lee KH BIOORGANIC & MEDICINAL CHEMISTRY 13 2325 2005/01
  •  A Simple Four Step Synthesis and Optical Resolution of 4-Nitro-1,3,4,5-tetrahydrobenz[cd]indole, and the Syntheses of 1-Hydroxy Derivatives of 4-Nitro and 4-Amino-1,3,4,5-tetrahydrobenz[cd]indoles Nakagawa K, Somei M 34 12 2269 1992/01
  •  Antitumor Agent 238. Anti-tubulin and in vitro Cytotoxic Effects of N-Substituted Allocolchicinoids  Nakagawa-Goto K, Jung MK, Hamel E, Wu CC, Bastow KF, Brossi A, Lee KH HETEROCYCLES 65 541 2005/01
  •  Antitumor Agent 236. Synthesis of Water-soluble Colchicine Derivatives Nakagawa-Goto K, Chen CX, Hamel E, Wu CC, Bastow KF, Brossi A, Lee KH BIOORGANIC & MEDICINAL CHEMISTRY LETTERS 15 235 2005/01
  •  Syntheses of ()-Clavicipitic Acid and its Derivatives Somei M, Hamamoto S, Nakagawa K, Yamada F, Ohta T HETEROCYCLES 37 2 719 1994/01
  •  Synthetic Study Directed Toward Novel Multi-Linked Heterocycles Somei M, Yamada Y, Kitagawa K, Sugaya K, Tomita Y, Yamada F, Nakagawa K HETEROCYCLES 45 3 435 1997/01
  •  Ergot Alkaloids: The First and Five Step Total Syntheses of (–)- and (+)-6,7-Secoagroclavine, and the Syntheses of (–)- and (+)-6-Nor-6-propyl-6, 7-secoagroclavines ((–)- and (+)-KSU 1415)  Nakagawa K, Somei M HETEROCYCLES 32 5 873 1991/01
  •  Simple Syntheses of Marine Alkaloid, ()-Chelonin A, and its Analogs Somei M, Aoki N, Nagahama Y, Nakagawa K HETEROCYCLES 41 1 5 1995/01
  •  The First Total Synthesis of () Chanoclavine-I Acid and an Alternative Total Synthesis of ()-Chanoclavine-I Somei M, Mukaiyama H, Nomura Y, Nakagawa K HETEROCYCLES 31 11 1919 1990/01
  •  Lithiation of 3-Dimethylaminomethyl- and 3-Dimethylaminoethyl-1-methoxyindole Derivatives, Heterocycles, 39 (1), 31-34 (1994).  Nakagawa K, Somei M HETEROCYCLES 39 1 31 1994/01
  •  Dopamine Receptor Stimulating Effects of Chanoclavine Analogous, Tricyclic Ergot Alkaloids, in the Brain  Watanabe H, Somei M, Sekihara S, Nakagawa K, Yamada F JAPANESE JOURNAL OF PHARMACOLOGY 45 501 1987/01
  •  Syntheses of ()-4-Amino-1,3,4,5-tetrahydrobenz[cd]indole-4-carboxylic Acid, ()-4-N,N-Dipropylamino-4-hydroxymethyl- and ()-4-Propyloxy-1,3,4,5-tetrahydrobenz[cd]indoles Somei M, Aoki N, Nakagawa K HETEROCYCLES 38 7 1479 1994/01

Conference Presentations

  • Creation of cell cycle inhibitors from natural skeletons(2017/11/26)
  • Drug discovery and development based on natural products(2017/07/10)
  • Total Synthesis of Bioactive Diterpene, Parvifloron F(conference:254th ACS National Meeting & Exposition)(2017/08/20)
  • Drug discovery and development by chemical modification of natural products(2015/09/30)
  • Benzothiophenyl flavones as new classes of mitotic inhibitors(conference:250th ACS National Meeting & Exposition)(2015/08/16)

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  • Medicines from nature(2013/02/09)

Arts and Fieldwork

Patent

○4-Amino-2H-pyran-2-one analogs as anticancer agents and their preparation (No: WO 2012061012 A2)
○Novel 4-amino-2H-benzo[h]chromen-2-one analogs as anti-cancer agents(No:No. 61/317,983)
○Desmosdumotins, their manufactures and use as antitumor and anti-aids agent. (No:WO2006069533)

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「ヌクレオチド除去修復機構解明に向けたケミカルアプローチ」(2019-2021) 
○「ジデルペンによる前立腺癌進展制御機構の解明と新規化合物の開発」(2019-2021) 
○「希少熱帯資源から新規創薬リードへの展開」(2018-2021) 
○「前立腺癌微小環境内での細胞間クロストークをターゲットとした革新的治療薬の開発」(2017-2019) 
○「インドネシア産自生植物および伝承薬の化学的保存」(2016-2019) 
○「新規DNA修復阻害剤を活用したメカニズム解析と癌治療への応用」(2016-2018) 
○「熱帯林植物からの新規抗がん剤候補薬の探索研究」(2013-2016) 
○「天然物由来小分子化合物を用いた多剤耐性がん選択性のケミカルバイオロジー」(2013-2015) 
○「ケミカルバイオロジーを利用したヒトヌクレオチド除去修復機構の解析 」(2013-2015) 
○「新規抗ガン性indolo[2,3-a]carbazole化合物群の合成研究 」(1994-) 
○「薬理活性1-ヒドロキシインドール化合物群の合成と反応 」(1993-) 
○「1-ヒドロキシインドール化学の展開と、循環器系疾患治療薬の開拓研究 」(1996-) 
○「薬理活性4位窒素置換benz[cd]indole化合物群の合成研究 」(1992-) 
○「薬理活性インド-ル化合物群の合成研究 」(1990-) 
○「2位に置換基を持つ新規な三環性麦角アルカロイド誘導体の合成研究 」(1990-) 
○「有機金属化合物を利用した環状化合物の新規クロスカップリング反応開拓研 」(1988-) 

Classes (Bachelors)

○World of Chemistry(2017)
○Natural Products Chemistry(2017)
○Experiments in Organic Chemistry(2017)
○World of Chemistry(2017)
○Experiments in Fundamental Chemistry(2017)
○World of Chemistry(2016)
○Laboratory Rotation 2(2016)
○Science of Natural Products(2016)
○Experiments in Organic Chemistry(2016)
○Experiments in Fundamental Chemistry(2016)
○World of Chemistry(2016)

Classes (Graduate Schools)

○Advanced Course of Organic Chemistry(2017)
○Bioorganic Chemistry(2017)
○Advanced Pharmacognosy(2017)
○Advanced Organic Chemistry III(2017)
○Advanced Seminar on Pharmachemistry(2017)
○Advanced Course of Pharmachemistry(2017)
○Advanced Organic Chemistry IV(2017)
○Advanced Pharmacognosy(2016)
○Introduction to Pharmaceutical Sciences(2016)
○Applied Pharmacognosy(2016)
○Advanced Pharmacognosy(2012)
○Applied Pharmacognosy(2012)

International Project

International Students

Lecture themes

Others (Social Activities)

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