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Researcher Information

last modified：2024/11/21

Assistant Professor　HARASHIMA, Ai

Mail

Faculty, Affiliation

Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences

College and School Educational Field


Laboratory

　TEL:076-265-2184

Academic Background

Career

(2016/02-)
(2011/04-2012/12)
(2013/01-2016/01)
(2018/01-2021/01)
(2007/04-2011/03)

Year & Month of Birth

Academic Society


IMARS

Award

Specialities

、、、、

Speciality Keywords

Research Themes

Books

Papers

  • 　 Dual nature of RAGE in host reaction and nurturing the mother-infant bond. 　Oshima Y, Harashima A, Munesue S, Kimura K, Leerach N, Goto H, Tanaka M, Niimura A, Hayashi K, Yamamoto H, Higashida H, Yamamoto Y.　Int J Mol Sci　23　4　2086　2022/02
  • 　Use of cocultures to measure the blood-brain barrier permeability of oxytocin.　Yamamoto Y, Harashima A, Munesue S, Higashida H.　Methods Mol Biol　2384　247-255　2022/01
  • 　 Postprandial induction of neutrophil extracellular trap formation in the blood.　Oshima Y, Tanaka M, Leerach N, Harashima A, Munesue S, Kimura K, Goto H, Hayashi K, Niimura A, Yamamoto Y.　Glycative Stress Res　8　4　183-189　2021/12
  • 　An improved sample extraction method reveals that plasma receptor for advanced glycation end-products (RAGE) modulates circulating free oxytocin in mice.　Cherepanov SM, Gerasimenko M, Yuhi T, Shabalova A, Zhu H, Yokoyama S, Salmina AB, Munesue S, Harashima A, Yamamoto Y, Higashida H.　Peptides　146　170649　2021/09
  • 　Dynamic switch of immunity and antitumor effects of metformin in rat spontaneous esophageal carcinogenesis. 　Takei R, Miyashita T, Takada S, Tajima H, Ninomiya I, Takamura H, Fushida S, Harashima A, Munesue S, Yagi S, Inaki N, Ohta T, Yamamoto Y.　Cancer Immunol　71　4　791-793　2021/04

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  • 　Pyridoxamine improves diabetes-evoked delayed bone repair in mice. 　Ugaji S, Kimura K, Yamamoto Y, Munesue S, Harashima A, Aikawa T, Yoshida Y, Hamada T, Hikichi T, Matsubara H, Tsuchiya H.　J Transl Sci　in press　in press　in press　2021/03
  • 　Receptor for advanced glycation end-products (RAGE) plays a critical role in retrieval behavior of mother mice at early postpartum.　Gerasimenko M, Lopatina O, Munesue S, Harashima A, Yokoyama S, Yamamoto Y, Higashida H.　Physiol Behav　in press　in press　in press　2021/03
  • 　RAGE signaling antagonist suppresses mouse macrophage foam cell formation　Nontaphat LEERACH, Seiichi MUNESUE, Ai HARASHIMA, Kumi KIMURA, Yu OSHIMA, Shuhei KAWANO, Mariko TANAKA, Akane NIIMURA, Natthiya SAKULSAK, Hiroshi YAMAMOTO, Osamu HORI, Yasuhiko YAMAMOTO　BBRC　in press　in press　in press　2021/03
  • 　Transport of oxytocin to the brain after peripheral administration by membrane-bound or soluble forms of receptors for advanced glycation end-products. 　Munesue S, Liang MingKun, Harashima A, Zhong J, Furuhara K, Boitsova E, Cherepanov SM, Gerasimenko M, Yuhi T, Yamamoto Y, Higashida H. 　J Neuroendocrinol 　in press　in press　in press　2021/03
  • 　Glycation reaction and the role of the receptor for advanced glycation end-products in immunity and social behavior. 　Leerach N, Harashima A, Munesue S, Kimura K, Oshima Y, Goto H, Yamamoto H, Higashida H, Yamamoto Y.　Glycoconj J 　in press　in press　in press　2020
  • 　Aquaporin 1 elicits cell motility and coordinates vascular bed formation by downregulating thrombospondin type-1 domain-containing 7A in glioblastoma.　Oishi M, Munesue S, Harashima A, Nakada M, Yamamoto Y, Hayashi Y. 　Cancer Med　9　11　3904-3917　2020
  • 　CD38, CD157 and RAGE as molecular determinants for social behavior.　Higashida H, Hashii M, Tanaka Y, Matsukawa S, Higuchi Y, Gabata R, Tsubomoto M, Seishima N, Teramachi M, Kamijima T, Hattori T, Hori O, Tsuji C, Cherepanov S, Shabalova A, Gerasimenko M, Minami K, Yokoyama S, Munesue S, Harashima A, Yamamoto Y, Salmina A, Lopatina O.　Cells　9　1　E62　2019
  • 　Protective role of endogenous secretory RAGE against contact hypersensitivity in mouse ear skin.　Sagara A, Harashima A, Munesue S, Kimura K, Leerach N, Oshima Y, Kinoshita Y, Sakai N, Kaneko S, Wada T, Tsuneyama K, Yamamoto H, Yamamoto Y. 　Glycative Stress Res　6　4　270　2019
  • 　Neuroprotective effects of endogenous secretory receptor for advanced glycation end-products in brain ischemia. 　Shimizu Y, Harashima A, Munesue S, Oishi M, Hattori T, Hori O, Kitao Y, Yamamoto H, Leerach N, Nakada M, Yamamoto Y, Hayashi Y. 　Aging Dis　in press　in press　2019
  • 　Monitoring of heat shock response and phenotypic changes in hepatocellular carcinoma after heat treatment. 　Zaimoku R, Miyashita T, Tajima H, Takamura H, Harashima A, Munesue S, Yamamoto Y, Ninomiya I, Fushida S, Harada K.　 Anticancer Res　39　10　5393　2019
  • 　Clonal hematopoiesis by SLIT1-mutated hematopoietic stem cells due to a breakdown of the autocrine loop involving Slit1 in acquired aplastic anemia.　Hosokawa K, Mizumaki H, Elbadry M, Saito C, Espinoza JL, An DTT, Katagiri T, Harashima A, Kikuchi A, Kanai A, Matsui H, Inaba T, Taniwaki M, Yamamoto Y, Nakao S.　Leukemia　33　2732　2019
  • 　Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice.　Yamamoto Y, Liang M, Munesue S, Deguchi K, Harashima A, Furuhara K, Yuhi T, Zhong J, Akther S, Goto H, Eguchi Y, Kitao Y, Hori O, Shiraishi Y, Ozaki N, Shimizu Y, Kamide T, Yoshikawa A, Hayashi Y, Nakada M, Lopatina O, Gerasimenko M, Komleva Y, Malinovskaya N, Salmina AB, Asano M, Nishimori K, Shoelson SE, Yamamoto H, Higashida H.　Commun Biol 　2　76　2019
  • 　 In vitro anticancer effects of a RAGE inhibitor discovered using a structure-based drug design system. 　El-Far A, Munesue S, Harashima A, Sato A, Shindo M, Nakajima S, Inada M, Tanaka M, Takeuchi A, Tsuchiya H, Yamamoto H, Shaheen HME, El-Sayed YS, Kawano S, Tanuma S, Yamamoto Y. 　Oncology Lett　15　4　4627-4634　2018
  • 　 Anti-tumor effects of a non-steroidal anti-inflammatory drug zaltoprofen on chondrosarcoma via activating peroxisome proliferator-activated receptor gamma and suppressing matrix metalloproteinase-2 expression. 　Higuchi T, Takeuchi, A, Munesue S, Yamamoto N, Hayashi K, Kimura H, Miwa S, Inatani H, Shimozaki S, Kato T, Aoki Y, Abe K, Taniguchi Y, Aiba H, Murakami H, Harashima A, Yamamoto Y, Tsuchiya H. 　Cancer Med　75　5　1944-1954　2018
  • 　Citrullinated histone H3: early biomarker of neutrophil extracellular traps in septic liver damage. 　Nomura K, Miyashita T, Yamamoto Y, Munesue S, Harashima A, Takayama H, Fushida S, Ohta T. 　J Surg Res 　234　132-138　2018
  • 　 Intestinal transepithelial permeability of oxytocin into the blood is dependent on the receptor for advanced glycation end products in mice. 　Higashida H, Furuhara K, Yamauchi AM, Deguchi K, Harashima A, Munesue S, Lopatina O, Gerasimenko M, Salmina AB, Zhang JS, Kodama H, Kuroda H, Tsuji C, Suto S, Yamamoto H, Yamamoto Y. 　Sci Rep 　in ress　2017
  • 　Low-dose paclitaxel suppresses the induction of M2 macrophages in gastric cancer.　Yamaguchi T, Fushida S, Yamamoto Y, Tsukada T, Kinoshita J, Oyama K, Miyashita T, Tajima H, Ninomiya I, Munesue S, Harashima A, Harada S, Yamamoto H and Ohta T.　Oncology Rep　37　3341-3350　2017
  • 　Contribution of methylglyoxal to delayed healing of bone injury in diabetes.　Aikawa T, Matsubara H, Ugaji S, Shirakawa J, Nagai R, Munesue S, Harashima A, Yamamoto Y, Tsuchiya H　Mol Med Rep　in press　2017
  • 　 Nurture vs. nature in diabetic vasculopathy: roles of advanced glycation endproducts and the receptor for them.　Yamamoto Y, Yonekura H, Sakurai S, Tanaka N, Li H, Myint KM, Kim CH, Harashima A, Osawa M, Takeuchi M, Watanabe T, Yamamoto H.　 International Congress Series, Atherosclerosis XIII 　1264　164-167　2004
  • 　Receptor for advanced glycation end products is a promising target of diabetic nephropathy.　Yamamoto Y, Doi T, Kato I, Shinohara H, Sakurai S, Yonekura H, Watanabe T, Myint KM, Harashima A, Takeuchi M, Takasawa S, Okamoto H, Hashimoto N, Asano M and Yamamoto H.　Ann N Y Acad Sci 　1043　562-566　2005
  • 　Blockade of diabetic vascular injury by controlling of AGE-RAGE system.　Myint KM, Yamamoto Y, Sakurai S, Harashima A, Watanabe T, Li H, Takeuchi A, Yoshimura K, Yonekura H and Yamamoto H　Curr Drug Targets　6　447-452　2005
  • 　 RAGE in diabetic nephropathy. 　Yamamoto H, Watanabe T, Yamamoto Y, Yonekura H, Munesue S, Harashima A, Ooe K, Hossain S, Saito H and Murakami N.　 Curr Mol Med 　7　752-757　2007
  • 　AVAQ594-597 deletion of the TfR2 gene in a Japanese family with hemochromatosis. 　Hattori A, Wakusawa S, Hayashi H, Harashima A, Sanae F, Kawanaka M, Yamada G, Yano M and Yoshioka K.　Hepatol Res 　26　154-156　2003
  • 　Compound load of copper and iron in the livers of pretreatment patients with wilson’s disease. 　Harashima A, Hattori A, Hayashi H, Wakusawa S, Kusakabe A, Fujita Y, Tanaka M, Yano M and Yoshioka K　J Tra Elem Exp Med 　17　65-73　2004
  • 　Identification of mouse ortholog of endogenous secretory receptor for advanced glycation end-products. : structure, function and expression.　Harashima A, Yamamoto Y, Cheng C, Tsuneyama K, Myint KM, Takeuchi A, Yoshimura K, Li H, Watanabe T, Takasawa S, Okamoto H, Yonekura H and Yamamoto Y.　Biochem J　396　109-115　2006
  • 　RAGE control of diabetic nephropathy in a mouse model.: effects of RAGE gene disruption and administration of low-molecular weight heparin. 　Myint KM, Yamamoto Y, Doi T, Kato I, Harashima A, Yonekura H, Watanabe T, Shinohara H, Takeuchi M, Hashimoto N, Asano M, Takasawa S, Okamoto H and Yamamoto H　Diabetes　55　2510-2500　2006
  • 　hosphorylation of the NFAR proteins by the dsRNA-dependent protein kinase, PKR, constitutes a novel mechanism of translational regulation and cellular defense.　Harashima A, Guettouche T and Barber GN　Genes Develop　24　2640-2653　2010
  • 　Preventive effect of salicylate and pyridoxamine on diabetic nephropathy.　Abouzed TK, Munesue S, Harashima A, Masuo Y, Kato Y, Khailo KKK, Yamamoto H, Yamamoto Y　 J Diabetes res　2016　1786789　2016
  • 　Short-chain aldehyde-derived ligands for RAGE and their actions on endothelial cells.　Yamamoto Y, Yonekura H, Watanabe T, Sakurai S, Li H, Harashima A, Myint KM, Osawa M, Takeuchi A, Takeuchi M and Yamamoto H.　Diabetes Res Clin Pract　77　S30-S40　2007
  • 　cAMP ameliorates inflammation by modulation of macrophage receptor for advanced glycation end-products. 　Motoyoshi S, Yamamoto Y, Munesue S, Igawa H, Harashima A, Saito H, Han D, Watanabe T, Sato H and Yamamoto H.　Biochem J　463　75-82　2014
  • 　STING recognition of cytoplasmic DNA instingates cellular defense. 　Abe T*, Harashima A*, Xia T, Konno H, Konno K, Morales A, Anh J, Gutman D and Barber GN.　Mol Cell 　50　5-15　2013
  • 　Tumor-associated macrophages of the M2 phenotype contribute to progression in gastric cancer with peritoneal dissemination.　Yamaguchi T, Fushida S, Yamamoto Y, Tsukada T, Kinoshita J, Oyama K, Miyashita T, Tajima H, Ninomiya I, Munesue S, Harashima A, Harada S, Yamamoto H, Ohta T.　Gastric Cancer　19　4　1052-65　2015
  • 　Septic Shock Is Associated with Receptor for Advanced Glycation End Products Ligation of LPS　Yamamoto, Yasuhiko;Harashima, Ai;Saito, Hidehito;Tsuneyama, Koichi;Munesue, Seiichi;Motoyoshi, So;Han, Dong;Watanabe, Takuo;Asano, Masahide;Takasawa, Shin;Okamoto, Hiroshi;Shimura, Satoshi;Karasawa, Tadahiro;Yonekura, Hideto;Yamamoto, Hiroshi　JOURNAL OF IMMUNOLOGY　186　5　3248-3257　2011
  • 　Low molecular weight heparin suppresses receptor for advanced glycation end products-mediated expression of malignant phenotype in human fibrosarcoma cells　Takeuchi, Akihiko; Yamamoto, Yasuhiko; Munesue, Seiichi; Harashima, Ai; Watanabe, Takuo; Yonekura, Hideto; Yamamoto, Hiroshi; Tsuchiya, Hiroyuki　Cancer Science　104　6　740-749　2013/06/01　
  • 　Low molecular Weight Heparin Suppresses RAGE-mediated Expression of Malignant Phenotype in Human Fibrosarcoma Cells.　Takeuchi A, Yamamoto Y, Munesue S, Harashima A, Watanabe T, Yonekura H, Yamamoto Y and Tsuchiya H.　Cancer Sci　104　740-749

Conference Presentations

  • 可溶型RAGEは脳血管内皮細胞上の膜型RAGEによる血中オキシトシンの脳内輸送を阻害しない(2020/11/06)
  • Drug library screening to identify new compounds for inducing ectodomain shedding of RAGE and formation of soluble RAGE(conference：International Maillard Reaction Society)(2018/09/10)
  • In vitro anticancer effects of a novel RAGE inhibitor on suppression of tumor malignant phenotypes in human fibrosarcoma cells(conference：International Maillard Reaction Society)(2018/09/10)
  • Impact of inhibiting RAGE-dependent Rac1 activities on AGE-induced macrophage invasion and lipid accumulation(conference：JMARS)(2018/10/06)
  • Preventive effect of salicylate and pyridoxamine on type I diabetic nephrophathy.(2017/12/06)

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  • In vitro effects of a novel RAGE inhibitor on tumor malignancy in human fibrosarcoma HT1080 cells(2017/12/06)
  • Drug library screening to identify candidates for inducing ectodomain shedding of RAGE and formation of soluble RAGE(2017/11/18)
  • Novel polymorphisms in promoter region of human glyoxalase 1 regulate its transcription and are associated with aging-related diseases (conference：Keystone Symposia Conference Aging and Mechanisms of Aging-Related Disease)(2017/05/16)
  • Effects of a novel RAGE inhibitor on suppression of tumor malignant phenotypes in human fibrosarcoma cells(2017/11/18)
  • Insufficient leptin action induces RAGE expression and triggers pancreatic beta-cell failure type 2 diabetes.(conference：12th International Symposium on the Maillard Reaction (ISMR) )
  • Neuroprotective effects of endogenous secretory rage in ischemic cerebrovasculr diseases.(conference：12th International Symposium on the Maillard Reaction (ISMR) )(2015/09)
  • Glyoxalase1 promoter polymorphism regulates gene transcription(2016/09/25)
  • Low-molecular weight heparin inhibits human fibrosarcoma cell proliferation, migration and invasion by blocking RAGE signaling(2013/09/13)

Others

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「線虫glad-4/GDL1遺伝子のエピジェネティクスな発現調節機構の解明」(2019-2021)　
○「オキシトシンの血液脳関門移行に関わる分子装置の解明と愛情の構築研究」(2018-2020)　
○「Glyoxalase1遺伝子多型に基づく統合失調症の病態解明と新規治療薬の創出」(2018-2020)　
○「解毒酵素グリオキザレースIの新規転写発現調節機構の解明」(2014-2015)　
○「グリオキザレース1の新規遺伝子多型による転写発現調節機構の解明」(2016-2017)　
○「Glyoxalase Iの転写発現制御機構の解析」

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

○Biochemistry 2(2021)
○Biochemistry 2(2020)
○Biochemistry2(2019)
○Biochemistry2(2017)
○Biochemistry2(2017)

Classes (Graduate Schools)

○Molecular Biology of the Cardiovascular System(2017)
○Molecular Biology of the Cardiovascular System(2017)
○Molecular Biology of the Cardiovascular System(2016)
○Molecular Biology of the Cardiovascular System(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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