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last modified：2024/01/08
Assistant Professor DOUMOTO, Takahiro
Faculty, Affiliation
Cancer Research Institute
College and School Educational Field
Laboratory
Academic Background
Career
Year & Month of Birth
Academic Society
Award
Specialities
Tumor biology、Tumor therapeutics、Molecular biology
Speciality Keywords
Cancer metastasis, Malignant progression
Research Themes
Books
Papers
- Discovery of a novel aminocyclopropenone compound that inhibits BRD4-driven nucleoporin NUP210 expression and attenuates colorectal cancer growth Hiroya Kondo, Kenji Mishiro, Yuki Iwashima, Yujia Qiu, Akiko Kobayashi, Keesiang Lim, Takahiro Domoto, Toshinari Minamoto, Kazuma Ogawa, Munetaka Kunishima, Masaharu Hazawa, Richard W Wong Cells 11 3 317 2022
- Glycogen synthase kinase 3β biology in bone and soft tissue sarcomas Kensaku Abe, Shingo Shimozaki, Takahiro Domoto, Norio Yamamoto, Hiroyuki Tsuchiya, Toshinari Minamoto Journal of Cancer Metastasis and Treatment 6 51 2020
- Glycogen synthase kinase-3β participates in acquired resistance to gemcitabine in pancreatic cancer Masahiro Uehara, Takahiro Domoto, Satoshi Takenaka, Dilireba Bolidong, Osamu Takeuchi, Tomoharu Miyashita, Toshinari Minamoto Cancer Science 111 12 4405-4416 2020
- Glycogen synthase kinase 3β in cancer biology and treatment Takahiro Domoto, Masahiro Uehara, Dilireba Bolidong, Toshinari Minamoto Cells 9 6 1388 2020
- Potential therapeutic effect of targeting glycogen synthase kinase 3β in esophageal squamous cell carcinoma Dilireba Bolidong, Takahiro Domoto, Masahiro Uehara, Hemragul Sabit, Tomoyuki Okumura, Yoshio Endo, Mitsutoshi Nakada, Itasu Ninomiya, Tomoharu Miyashita, Richard W Wong, Toshinari Minamoto Scientific Reports 10 1 11807 2020
- Glycogen synthase kinase 3β as a potential therapeutic target in synovial sarcoma and fibrosarcoma Kensaku Abe, Norio Yamamoto, Takahiro Domoto, Dilireba Bolidong, Katsuhiro Hayashi, Akihiko Takeuchi, Shinji Miwa, Kentaro Igarashi, Hiroyuki Inatani, Yu Aoki, Takashi Higuchi, Yuta Taniguchi, Hirotaka Yonezawa, Yoshihiro Araki, Hisaki Aiba, Toshinari Minamoto, Hiroyuki Tsuchiya Cancer Science 111 2 429-40 2020
- Identification of GSK3β inhibitor kenpaullone as a temozolomide enhancer against glioblastoma Tomohiro Kitabayashi, Yu Dong, Takuya Furuta, Hemragul Sabit, Shabierjiang Jiapaer, Jiakang Zhang, Guangtao Zhang, Yasuhiko Hayashi, Masahiko Kobayashi, Takahiro Domoto, Toshinari Minamoto, Atsushi Hirao, Mitsutoshi Nakada Scientific Reports 9 1 10049 2019
- Colorectal cancer cells require glycogen synthase kinase-3β for sustaining mitosis via translocated promoter region (TPR)-dynein interaction Firli R.P. Dewi, Takahiro Domoto, Masaharu Hazawa, Akiko Kobayashi, Takayuki Douwaki, Toshinari Minamoto, Richard W. Wong Oncotarget 9 17 13337-52 2018
- Efficacy of glycogen synthase kinase-3β targeting against osteosarcoma via activation of β-catenin Shingo Shimozaki, Norio Yamamoto, Takahiro Domoto, Hideji Nishida, Katsuhiro Hayashi, Hiroaki Kimura, Akihiko Takeuchi, Shinji Miwa, Kentaro Igarashi, Takashi Kato, Yu Aoki, Takashi Higuchi, Mayumi Hirose, Robert M Hoffman, Toshinari Minamoto, Hiroyuki Tsuchiya Oncotarget 7 47 77038-51 2016
- Glycogen synthase kinase-3β is a pivotal mediator of cancer invasion and resistance to therapy Takahiro Domoto, Ilya V. Pyko, Takuya Furuta, Katsuyoshi Miyashita, Masahiro Uehara, Takeo Shimasaki, Mitsutoshi Nakada, Toshinari Minamoto Cancer Science 107 10 1363-72 2016
- Tip60 regulates MT1-MMP transcription and invasion of glioblastoma cells through NF-κB pathway Takahisa Takino, Mitsutoshi Nakada, Zichen Li, Taisuke Yoshimoto, Takahiro Domoto, Hiroshi Sato Clinical & Experimental Metastasis 33 1 45-52. 2016
- Glycogen synthase kinase 3β sustains invasion of glioblastoma via the focal adhesion kinase, Rac1, and c-Jun N-terminal kinase-mediated pathway Yuri Chikano, Takahiro Domoto, Takuya Furuta, Hemragul Sabit, Ayako Kitano-Tamura, Ilya V. Pyko, Takahisa Takino, Yoshimichi Sai, Yutaka Hayashi, Hiroshi Sato, Ken-ichi Miyamoto, Mitsutoshi Nakada, Toshinari Minamoto Molecular Cancer Therapeutics 14 2 564-74 2015
- Vinculin negatively regulates transcription of MT1-MMP through MEK/ERK pathway Taisuke Yoshimoto, Takahisa Takino, Zichen Li, Takahiro Domoto, Hiroshi Sato Biochemical and Biophysical Research Communications 455 3-4 251-5 2014
- Membrane-type 1 matrix metalloproteinase regulates fibronectin assembly and N-cadherin adhesion Takahisa Takino, Taisuke Yoshimoto, Mitsutoshi Nakada, Zichen Li, Takahiro Domoto, Shuichi Kawashiri, Hiroshi Sato Biochemical and Biophysical Research Communications 450 2 1016-20 2014
- MT1-MMP prevents growth inhibition by three dimensional fibronectin matrix Takahisa Takino, Luyang Guo, Takahiro Domoto, Hiroshi Sato Biochemical and Biophysical Research Communications 436 3 503-8 2013
- Shedding of kidney injury molecule-1 by membrane-type 1 matrix metalloproteinase Luyang Guo, Takahisa Takino, Yoshio Endo, Takahiro Domoto, Hiroshi Sato The Journal of Biochemistry 152 5 425-32 2012
- Cleavage of hepatocyte growth factor activator inhibitor-1 by membrane-type MMP-1 activates matriptase Takahiro Domoto, Takahisa Takino, Luyang Guo, Hiroshi Sato Cancer Science 103 3 448-54 2012
- Membrane-type 1 matrix metalloproteinase regulates fibronectin assembly to promote cell motility Takahisa Takino, Ryota Nagao, Ri-ichiroh Manabe, Takahiro Domoto, Kiyotoshi Sekiguchi, Hiroshi Sato FEBS Letters 585 21 3378-84 2011
- GI24 enhances tumor invasiveness by regulating cell surface membrane-type 1 matrix metalloproteinase Moustafa A. Sakr, Takahisa Takino, Takahiro Domoto, Hiroshi Nakano, Richard W. Wong, Motoko Sasaki, Yasuni Nakanuma, Hiroshi Sato Cancer Science 101 11 2368-74 2010
Conference Presentations
- GSK3β interconnects the malignant properties in therapy-resistant pancreatic cancer (conference：The 32nd Annual Meeting of the Japanese Society for Gastroenterological Carcinogenesis (JSGC) / The 10th International Conference of the International Society of Gastroenterological Carcinogenesis (ISGC))(2021/11/27)
- Glycogen synthase kinase (GSK)3β renders pancreatic cancer acquiring resistance to gemcitabine via STAT3 activation(2021/10/02)
- GSK3β interconnects cancer stemness and invasive capacity in pancreatic cancer with acquired resistance to gemcitabine(2020/10/01)
- Role of GSK3β in malignant progression of pancreatic cancer associated with gemcitabine resistance(2020/07/16)
- Glycogen synthase kinase (GSK)3β links tumor stemness, invasion and acquisition of drug resistance in pancreatic cancer (2019/09/26)
- GSK3β enhances stemness and invasion of pancreatic cancer in acquiring resistance to gemcitabine(2019/07/25)
- GSK3β participates in tumor-promoting metabolism in colon cancer(2018/11/16)
- Involvement of aberrant GSK3β in tumor-promoting autophagy in colorectal cancer (conference：The 13th International Symposium of the Institute Network for Biomedical Sciences joint with the 3rd Symposium of the Inter-University Research Network for Trans-Omics Medicine and the 28th Hot Spring Harbor Symposium)(2018/10/18)
- Glycogen synthase kinase (GSK) 3β induces protooncogenic autophagy in colon cancer (2018/09/27)
- 大腸がんの腫瘍促進的エネルギー代謝におけるGSK3βの病理作用 (2018/02/02)
- Aberrant glycogen synthase kinase (GSK) 3β participates in tumor-promoting autophagy in colorectal cancer (2017/11/17)
- Glycogen synthase kinase (GSK)3β facilitates invasive capacity in pancreatic cancer with acquired gemcitabine resistance (2017/09/28)
- Glycogen synthase kinase (GSK)-3β participates in colon cancer cell survival via sustaining tumor-promoting autophagy (2016/10/06)
- GSK3β sustains invasion of glioblastoma by expression of MMPs via the FAK, Rac1 and JNK-mediated pathway (2015/10/08)
- Glycogen synthase kinase 3b sustains invasion of glioblastoma via the focal adhesion kinase, Rac1 and JNK-mediated pathway (2015/01/22)
- Involvement of GSK3β in aberrant glucose metabolism in colon cancer (2014/09/25)
- Inhibition of GSK3β rectifies aberrant glucose metabolism in colon cancer cells (conference：International Symposium on Tumor Biology in Kanazawa & Symposium on Drug Discoverry in Academics )(2014/01/23)
- Putative pathological role of GSK3βin aberrant glucose metabolism in colon cancer cells (2013/10/03)
- Cleavage of hepatocyte growth factor activator inhibitor-1 by membrane-type MMP-1 stimulates tumor invasion and metastasis(conference：The 3rd International Symposium on Carcinogenic Spiral - International Symposium on Tumor Biology in Kanazawa)(2013/01/24)
- Activation of serine protease through the cleavage of HAI-1 promotes tumor cell migration and invasion (2012/09/19)
- Cleavage of hepatocyte growth factor activator inhibitor-1 by membrane-type MMP-1 stimulates tumor invasive growth (conference：The Joint Symposium of the 7th International Symposium of the Institute Network)(2012/06/14)
- MT1-MMP activates matriptase through the cleavage of its inhibitor HAI-1(2011/10/03)
- MT1-MMP regulates serine proteinase activation cascade through the cleavage of HAI-1 (2010/09/22)
- GSK3β participates in malignant properties of pancreatic cancer acquiring chemoresistance(2022/09/30)
- GSK3β integrates acquired chemoresistance, invasive capacity and tumor stemness in refractory pancreatic cancer(2022/11/11)
- GSK3β interconnects tumor invasion and stemness in pancreatic cancer acquiring resistance to gemcitabine(conference：The 7th JCA-AACR Special Joint Conference The Latest Advances in Pancreatic Research: From Basic Science to Therapeutics)(2022/07/08)
Others
Arts and Fieldwork
Patent
Theme to the desired joint research
Grant-in-Aid for Scientific Research
○「抗がん剤耐性獲得膵がん細胞における悪性形質連関の解明と治療法開発」(2022-2024)
○「GSK3βによるがん促進的糖代謝特性の解明と制御への応用」(2019-2021)
○「GSK3βが制御するがん特異的エネルギー獲得機構の解明とがん治療への応用」(2017-2018)
○「エネルギー代謝特性に基づく消化器がん病態解明と制御への応用」(2013-2015)
Competitive research funding,Contribution
Collaborative research,Consignment study
Classes (Bachelors)
Classes (Graduate Schools)
○Clinical and Molecular Oncology(2022)
○Human Molecular biology 2(2022)
○Bioscience of Cancer Ⅰb(2022)
○Biology of Cancer 1B(2022)
○Human Molecular biology 2(2021)
○Bioscience of Cancer Ⅰb(2021)
○Biology of Cancer 1B(2021)
○Seminar on Tumor Biology(2020)
○Clinical and Molecular Oncology(2020)
○Clinical and Molecular Oncology(2020)
○Seminar on Tumor Biology(2019)
○Clinical and Molecular Oncology(2019)
○Clinical and Molecular Oncology(2019)
○Clinical and Molecular Oncology(2018)
○Seminar on Tumor Biology(2018)
○Seminar on Tumor Biology(2017)
○Clinical and Molecular Oncology(2017)
○Clinical and Molecular Oncology(2017)
○Clinical and Molecular Oncology(2016)
○Clinical and Molecular Oncology(2016)
○Seminar on Tumor Biology(2016)