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Researcher Information

last modified：2024/11/21

Professor　DAIKOKU, Takiko

Faculty, Affiliation

Research Center for Experimental Modeling of Human Disease　Research Center for Experimental Modeling of Human Disease

College and School Educational Field


Laboratory

Academic Background

Career

University of Kansas Medical Center, USA　Department of Biochemistry　Postdoctoral Fellow(2000/04-2001/09)
University of Kansas Medical Center, USA　Department of Molecular and Integrative　Postdoctoral Fellow(2001/09-2002/06)
Vanderbilt University Medical Center, USA　Department of Pediatrics　Postdoctoral Fellow(2002/07-2004/02)
Vanderbilt University Medical Center, USA　Department of Pediatrics　Research Assistant Professor(2004/03-2008/05)
Cincinnati Children’s Hospital Medical Center, USA　Division of Reproductive Sciences　Research Assistant Professor(2008/05-2011/08)
Cincinnati Children’s Hospital Medical Center, USA　Division of Reproductive Sciences　Research Associate Professor(2011/09-2015/06)

Year & Month of Birth

1973/01

Academic Society





Award

Specialities

Speciality Keywords

Research Themes

Books

Papers

  • 　Adolescent Dietary Habit-induced Obstetric and Gynecologic Disease (ADHOGD) as a New Hypothesis-Possible Involvement of Clock System.　Tomoko Fujiwara,Masanori Ono,Michihiro Mieda,Hiroaki Yoshikawa,Rieko Nakata,Takiko Daikoku,Naomi Sekizuka-Kagami,Yoshiko Maida,Hitoshi Ando,Hiroshi Fujiwara　Nutrients　12　5　2020/05/02
  • 　The lack of terminal tubule cells in the submandibular gland of mice deficient in submandibular gland protein C.　Hiroki Nakata,Jumpei Terakawa,Shin-Ichi Horike,Takiko Daikoku,Shoichi Iseki　Cell and tissue research　381　2　229　2020/05/16
  • 　Promoting Roles of Embryonic Signals in Embryo Implantation and Placentation in Cooperation with Endocrine and Immune Systems.　Hiroshi Fujiwara,Masanori Ono,Yukiyasu Sato,Kazuhiko Imakawa,Takashi Iizuka,Kyosuke Kagami,Tomoko Fujiwara,Akihito Horie,Hirohiko Tani,Akira Hattori,Takiko Daikoku,Yoshihiko Araki　International journal of molecular sciences　21　5　2020/03/10
  • 　The Association and Significance of p53 in Gynecologic Cancers: The Potential of Targeted Therapy.　Mitsuhiro Nakamura,Takeshi Obata,Takiko Daikoku,Hiroshi Fujiwara　International journal of molecular sciences　20　21　2019/11/04
  • 　Cyclooxygenase-1 is a potential target for prevention and treatment of ovarian epithelial cancer　T Daikoku,DZ Wang,S Tranguch,JD Morrow,S Orsulic,RN DuBois,SK Dey　CANCER RESEARCH　65　9　3735　2005/05

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  • 　Ovarian insufficiency and CTNNB1 mutations drive malignant transformation of endometrial hyperplasia with altered PTEN/PI3K activities.　Terakawa J,Serna VA,Taketo MM,Daikoku T,Suarez AA,Kurita T　Proceedings of the National Academy of Sciences of the United States of America　2019/02
  • 　IMP dehydrogenase-2 drives aberrant nucleolar activity and promotes tumorigenesis in glioblastoma.　Satoshi Kofuji,Akiyoshi Hirayama,Alexander Otto Eberhardt,Risa Kawaguchi,Yuki Sugiura,Oltea Sampetrean,Yoshiki Ikeda,Mikako Warren,Naoya Sakamoto,Shuji Kitahara,Hirofumi Yoshino,Daisuke Yamashita,Kazutaka Sumita,Kara Wolfe,Lisa Lange,Satsuki Ikeda,Hiroko Shimada,Noriaki Minami,Akshiv Malhotra,Shin Morioka,Yuki Ban,Maya Asano,Victoria L Flanary,Annmarie Ramkissoon,Lionel M L Chow,Juri Kiyokawa,Tomoyuki Mashimo,Greg Lucey,Sergey Mareninov,Tatsuya Ozawa,Nobuyuki Onishi,Koichi Okumura,Jumpei Terakawa,Takiko Daikoku,Trisha Wise-Draper,Nazanin Majd,Kaori Kofuji,Mika Sasaki,Masaru Mori,Yonehiro Kanemura,Eric P Smith,Dimitrios Anastasiou,Hiroaki Wakimoto,Eric C Holland,William H Yong,Craig Horbinski,Ichiro Nakano,Ralph J DeBerardinis,Robert M Bachoo,Paul S Mischel,Wataru Yasui,Makoto Suematsu,Hideyuki Saya,Tomoyoshi Soga,Ingrid Grummt,Holger Bierhoff,Atsuo T Sasaki　Nature cell biology　21　8　1003　2019/08
  • 　Novel strategy of ovarian cancer implantation: Pre-invasive growth of fibrin-anchored cells with neovascularization　Ayumi Matsuoka,Yasunari Mizumoto,Masanori Ono,Kyosuke Kagami,Takeshi Obata,Junpei Terakawa,Yoshiko Maida,Mitsuhiro Nakamura,Takiko Daikoku,Hiroshi Fujiwara　Cancer Science　110　8　2658　2019
  • 　Development of a Highly Potent Analogue and a Long-Acting Analogue of Oxytocin for the Treatment of Social Impairment-Like Behaviors.　Wataru Ichinose,Stanislav M Cherepanov,Anna A Shabalova,Shigeru Yokoyama,Teruko Yuhi,Hiroaki Yamaguchi,Ayu Watanabe,Yasuhiko Yamamoto,Hiroshi Okamoto,Shinichi Horike,Junpei Terakawa,Takiko Daikoku,Mizuki Watanabe,Nariyasu Mano,Haruhiro Higashida,Satoshi Shuto　Journal of medicinal chemistry　62　7　3297　2019/04/11
  • 　Time Restriction of Food Intake during the Circadian Cycle Is a Possible Regulator of Reproductive Function in Postadolescent Female Rats　Tomoko Fujiwara,Rieko Nakata,Masanori Ono,Michihiro Mieda,Hitoshi Ando,Takiko Daikoku,Hiroshi Fujiwara　Current Developments in Nutrition　3　4　nzy093　2019/03/11
  • 　The uterine epithelial loss of Pten is inefficient to induce endometrial cancer with intact stromal Pten.　Liang X,Daikoku T,Terakawa J,Ogawa Y,Joshi AR,Ellenson LH,Sun X,Dey SK　PLoS genetics　14　8　e1007630　2018/08
  • 　Crosstalk between PKCα and PI3K/AKT Signaling Is Tumor Suppressive in the Endometrium.　Hsu AH,Lum MA,Shim KS,Frederick PJ,Morrison CD,Chen B,Lele SM,Sheinin YM,Daikoku T,Dey SK,Leone G,Black AR,Black JD　Cell reports　24　3　655　2018/07
  • 　Factors Regulating Human Extravillous Trophoblast Invasion: Chemokine-peptidase and CD9-integrin Systems.　Hiroshi Fujiwara,Hisanori Matsumoto,Yukiyasu Sato,Akihito Horie,Masanori Ono,Mitsuhiro Nakamura,Yasunari Mizumoto,Kyosuke Kagami,Tomoko Fujiwara,Akira Hattori,Yoshiko Maida,Takiko Daikoku,Kazuhiko Imakawa,Yoshihiko Araki　Current pharmaceutical biotechnology　19　10　764　2018
  • 　Dual expression of immunoreactive estrogen receptor beta and p53 is a potential predictor of regional lymph node metastasis and postoperative recurrence in endometrial endometrioid carcinoma　Takeshi Obata,Mitsuhiro Nakamura,Yasunari Mizumoto,Takashi Iizuka,Masanori Ono,Jumpei Terakawa,Takiko Daikoku,Hiroshi Fujiwara　PLOS ONE　12　11　e0188641　2017/11
  • 　The Lipid Kinase PI5P4K beta Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis　Kazutaka Sumita,Yu-Hua Lo,Koh Takeuchi,Miki Senda,Satoshi Kofuji,Yoshiki Ikeda,Jumpei Terakawa,Mika Sasaki,Hirofumi Yoshino,Nazanin Majd,Yuxiang Zheng,Emily Rose Kahoud,Takehiro Yokota,Brooke M. Emerling,John M. Asara,Tetsuo Ishida,Jason W. Locasale,Takiko Daikoku,Dimitrios Anastasiou,Toshiya Senda,Atsuo T. Sasaki　MOLECULAR CELL　61　2　187　2016/01
  • 　The Lipid Kinase PI5P4Kβ Is an Intracellular GTP Sensor for Metabolism and Tumorigenesis.　Kazutaka Sumita,Yu-Hua Lo,Koh Takeuchi,Miki Senda,Satoshi Kofuji,Yoshiki Ikeda,Jumpei Terakawa,Mika Sasaki,Hirofumi Yoshino,Nazanin Majd,Yuxiang Zheng,Emily Rose Kahoud,Takehiro Yokota,Brooke M Emerling,John M Asara,Tetsuo Ishida,Jason W Locasale,Takiko Daikoku,Dimitrios Anastasiou,Toshiya Senda,Atsuo T Sasaki　Mol. Cell　61　2　187　2016/01
  • 　Dual Positive Regulation of Embryo Implantation by Endocrine and Immune Systems - Step-by-Step Maternal Recognition of the Developing Embryo　Hiroshi Fujiwara,Yoshihiko Araki,Kazuhiko Imakawa,Shigeru Saito,Takiko Daikoku,Minoru Shigeta,Hideharu Kanzaki,Takahide Mori　AMERICAN JOURNAL OF REPRODUCTIVE IMMUNOLOGY　75　3　281　2016/03
  • 　SSK1, a novel GTP-dependent kinase, detects GTP levels and regulates tumorigenesis　Sumita K,Takeuchi K,Lo Y,Senda M,Kofuji S,Ikeda Y,Yoshino H,Sasaki M,Terakawa J,Daikoku T,Cantley L. C,Senda T,Sasaki A. T　Molecular Biology of the Cell　26　2015　
  • 　Neutrophils Oppose Uterine Epithelial Carcinogenesis via Debridement of Hypoxic Tumor Cells　Adam Blaisdell,Amandine Crequer,Devin Columbus,Takiko Daikoku,Khush Mittal,Sudhansu K. Dey,Adrian Erlebacher　CANCER CELL　28　6　785　2015/12
  • 　Ovarian LGR5 is critical for successful pregnancy　Xiaofei Sun,Jumpei Terakawa,Hans Clevers,Nick Barker,Takiko Daikoku,Sudhansu K. Dey　FASEB JOURNAL　28　5　2380　2014/05
  • 　Lactoferrin-iCre: A New Mouse Line to Study Uterine Epithelial Gene Function　Takiko Daikoku,Yuya Ogawa,Jumpei Terakawa,Akiyo Ogawa,Tony DeFalco,Sudhansu K. Dey　ENDOCRINOLOGY　155　7　2718　2014/07
  • 　Possible roles of the cAMP-mediators EPAC and RAP1 in decidualization of rat uterus　Kazuya Kusama,Mikihiro Yoshie,Kazuhiro Tamura,Takiko Daikoku,Tsutomu Takarada,Eiichi Tachikawa　REPRODUCTION　147　6　897　2014/06
  • 　Ovarian stimulation using human chorionic gonadotrophin impairs blastocyst implantation and decidualization by altering ovarian hormone levels and downstream signaling in mice　Kenji Ezoe,Takiko Daikoku,Akiko Yabuuchi,Nana Murata,Hiroomi Kawano,Takashi Abe,Takashi Okuno,Tamotsu Kobayashi,Keiichi Kato　MOLECULAR HUMAN REPRODUCTION　20　11　1101　2014/11
  • 　Mammalian Target of Rapamycin Complex 1 and Cyclooxygenase 2 Pathways Cooperatively Exacerbate Endometrial Cancer　Takiko Daikoku,Jumpei Terakawa,Md M. Hossain,Mikihiro Yoshie,Monica Cappelletti,Peiying Yang,Lora H. Elenson,Sudhansu K. Dey　AMERICAN JOURNAL OF PATHOLOGY　184　9　2390　2014/09
  • 　A review of the potential utility of Mycophenolate Mofetil as a cancer therapeutic.　Majd N,Sumita K,Yoshino H,Chen D,Terakawa J,Daikoku T,Kofuji S,Curry R,Wise-Draper T,Warnick R,Guarnaschelli J,Sasaki AT　Journal of Cancer Research　ID 423401　2014
  • 　A new role for muscle segment homeobox genes in mammalian embryonic diapause　Jeeyeon Cha,Xiaofei Sun,Amanda Bartos,Jane Fenelon,Pavine Lefevre,Takiko Daikoku,Geoff Shaw,Robert Maxson,Bruce D. Murphy,Marilyn B. Renfree,Sudhansu K. Dey　OPEN BIOLOGY　3　4　130035　2013/04
  • 　Conditional deletion of Tsc1 in the female reproductive tract impedes normal oviductal and uterine function by enhancing mTORC1 signaling in mice　Takiko Daikoku,Mikihiro Yoshie,Huirong Xie,Xiaofei Sun,Jeeyeon Cha,Lora Hedrick Ellenson,Sudhansu K. Dey　MOLECULAR HUMAN REPRODUCTION　19　7　463　2013/07
  • 　CXCR2-Expressing Myeloid-Derived Suppressor Cells Are Essential to Promote Colitis-Associated Tumorigenesis　Hiroshi Katoh,Dingzhi Wang,Takiko Daikoku,Haiyan Sun,Sudhansu K. Dey,Raymond N. DuBois　CANCER CELL　24　5　631　2013/11
  • 　Differential Expression of the Motin Family in the Pen-implantation Mouse Uterus and Their Hormonal Regulation　Hiromichi Matsumoto,Emiko Fukui,Midori Yoshizawa,Eimei Sato,Takiko Daikoku　JOURNAL OF REPRODUCTION AND DEVELOPMENT　58　6　649　2012/12
  • 　Wakayama Symposium: Epithelial-Mesenchymal Interaction Regulates Tissue Formation and Characteristics: Insights for Corneal Development　Kentaro Suzuki,Chikako Yokoyama,Yujiro Higashi,Takiko Daikoku,Shin Mizoguchi,Shizuya Saika,Gen Yamada　OCULAR SURFACE　10　4　217　2012/10
  • 　Uterine Deletion of Trp53 Compromises Antioxidant Responses in the Mouse Decidua　Kristin E. Burnum,Yasushi Hirota,Erin S. Baker,Mikihiro Yoshie,Yehia M. Ibrahim,Matthew E. Monroe,Gordon A. Anderson,Richard D. Smith,Takiko Daikoku,Sudhansu K. Dey　ENDOCRINOLOGY　153　9　4568　2012/09
  • 　Galectin-1 Markedly Reduces the Incidence of Resorptions in Mice Missing Immunophilin FKBP52　Yasushi Hirota,Kristin E. Burnum,Nuray Acar,Gabriel A. Rabinovich,Takiko Daikoku,Sudhansu K. Dey　ENDOCRINOLOGY　153　5　2486　2012/05
  • 　Cyclocreatine treatment improves cognition in mice with creatine transporter deficiency　Yuko Kurosawa,Ton J. DeGrauw,Diana M. Lindquist,Victor M. Blanco,Gail J. Pyne-Geithman,Takiko Daikoku,James B. Chambers,Stephen C. Benoit,Joseph F. Clark　JOURNAL OF CLINICAL INVESTIGATION　122　8　2837　2012/08
  • 　Conditional Deletion of MSX Homeobox Genes in the Uterus Inhibits Blastocyst Implantation by Altering Uterine Receptivity　Takiko Daikoku,Jeeyeon Cha,Xiaofei Sun,Susanne Tranguch,Huirong Xie,Tomoko Fujita,Yasushi Hirota,John Lydon,Francesco DeMayo,Robert Maxson,Sudhansu K. Dey　DEVELOPMENTAL CELL　21　6　1014　2011/12
  • 　Heightened uterine mammalian target of rapamycin complex 1 (mTORC1) signaling provokes preterm birth in mice　Yasushi Hirota,Jeeyeon Cha,Mikihiro Yoshie,Takiko Daikoku,Sudhansu K. Dey　PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　108　44　18073　2011/11
  • 　Cell-specific conditional deletion of Pten in the uterus results in differential phenotypes　Takiko Daikoku,Lindsey Jackson,Valerie Besnard,Jeffrey Whitsett,Lora Hedrick Ellenson,Sudhansu K. Dey　GYNECOLOGIC ONCOLOGY　122　2　424　2011/08
  • 　Uterine FK506-binding protein 52 (FKBP52)-peroxiredoxin-6 (PRDX6) signaling protects pregnancy from overt oxidative stress　Yasushi Hirota,Nuray Acar,Susanne Tranguch,Kristin E. Burnum,Huirong Xie,Ako Kodama,Yutaka Osuga,Ismail Ustunel,David B. Friedman,Richard M. Caprioli,Takiko Daikoku,Sudhansu K. Dey　PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　107　35　15577　2010/08
  • 　Uterine-specific p53 deficiency confers premature uterine senescence and promotes preterm birth in mice　Yasushi Hirota,Takiko Daikoku,Susanne Tranguch,Huirong Xie,Heather B. Bradshaw,Sudhansu K. Dey　JOURNAL OF CLINICAL INVESTIGATION　120　3　803　2010/03
  • 　Polypyrimidine tract-binding protein is relocated to the cytoplasm and is required during dengue virus infection in Vero cells　Raul Azael Agis-Juarez,Ivan Galvan,Fernando Medina,Takiko Daikoku,R. Padmanabhan,Juan E. Ludert,Rosa M. del Angel　JOURNAL OF GENERAL VIROLOGY　90　Pt 12　2893　2009/12
  • 　In Pursuit of Leucine-Rich Repeat-Containing G Protein-Coupled Receptor-5 Regulation and Function in the Uterus　Xiaofei Sun,Lindsey Jackson,Sudhansu K. Dey,Takiko Daikoku　ENDOCRINOLOGY　150　11　5065　2009/11
  • 　CYP1B1 expression in ovarian cancer in the laying hen Gallus domesticus　Yan Zhuge,Jo Ann J. Lagman,Kristine Ansenberger,Cassandra J. Mahon,Takiko Daikoku,Sudhansu K. Dey,Janice M. Bahr,Dale B. Hales　GYNECOLOGIC ONCOLOGY　112　1　171　2009/01
  • 　Deficiency of Immunophilin FKBP52 Promotes Endometriosis　Yasushi Hirota,Susanne Tranguch,Takiko Daikoku,Akiko Hasegawa,Yutaka Osuga,Yuji Taketani,Sudhansu K. Dey　AMERICAN JOURNAL OF PATHOLOGY　173　6　1747　2008/12
  • 　Two faces of PTEN　Takiko Daikoku,Sudhansu K. Dey　NATURE MEDICINE　14　11　1192　2008/11
  • 　Conditional loss of uterine Pten unfailingly and rapidly induces endometrial cancer in mice　Takiko Daikoku,Yasushi Hirota,Susanne Tranguch,Ayesha R. Joshi,Francesco J. DeMayo,John P. Lydon,Lora H. Ellenson,Sudhansu K. Dey　CANCER RESEARCH　68　14　5619　2008/07
  • 　Imaging mass spectrometry reveals unique protein profiles during embryo implantation　Kristin E. Burnum,Susanne Tranguch,Deming Mi,Takiko Daikoku,S. K. Dey,Richard M. Caprioli　ENDOCRINOLOGY　149　7　3274　2008/07
  • 　Heparanase expression and function during early pregnancy in mice　Sonia S. D'Souza,Takiko Daikoku,Mary C. Farach-Carson,Daniel D. Carson　BIOLOGY OF REPRODUCTION　77　3　433　2007/09
  • 　MicroRNA regulation of cyclooxygenase-2 during embryo implantation　Anindita Chakrabarty,Susanne Tranguch,Takiko Daikoku,Kevin Jensen,Henry Furneaux,Sudhansu K. Dey　PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　104　38　15144　2007/09
  • 　FKBP52 deficiency-conferred uterine progesterone resistance is genetic background and pregnancy stage specific　Susanne Tranguch,Haibin Wang,Takiko Daikoku,Huirong Xie,David F. Smith,Sudhansu K. Dey　JOURNAL OF CLINICAL INVESTIGATION　117　7　1824　2007/07
  • 　Extracellular signal-regulated kinase is a target of cyclooxygenase-1-peroxisome proliferator-activated receptor-delta signaling in epithelial ovarian cancer　Takiko Daikoku,Susanne Tranguch,Anindita Chakrabarty,Dingzhi Wang,Dineo Khabele,Sandra Orsulic,Jason D. Morrow,Raymond N. DuBois,Sudhansu K. Dey　CANCER RESEARCH　67　11　5285　2007/06
  • 　Levels of NAD(+)-dependent 15-hydroxyprostaglandin dehydrogenase are reduced in inflammatory bowel disease: evidence for involvement of TNF-alpha　T Otani,K Yamaguchi,E Scherl,BH Du,HH Tai,M Greifer,L Petrovic,T Daikoku,SK Dey,K Subbaramaiah,AJ Dannenberg　AMERICAN JOURNAL OF PHYSIOLOGY-GASTROINTESTINAL AND LIVER PHYSIOLOGY　290　2　G361　2006/02
  • 　Cyclooxygenase-1 is overexpressed in multiple genetically engineered mouse models of epithelial ovarian cancer　T Daikoku,S Tranguch,IN Trofimova,DM Dinulescu,T Jacks,AY Nikitin,DC Connony,SK Dey　CANCER RESEARCH　66　5　2527　2006/03
  • 　CXCL1 induced by prostaglandin E-2 promotes angiogenesis in colorectal cancer　DZ Wang,HB Wang,J Brown,T Daikoku,W Ning,Q Shi,A Richmond,R Strieter,SK Dey,RN DuBois　JOURNAL OF EXPERIMENTAL MEDICINE　203　4　941　2006/04
  • 　Proteomic analysis identifies immunophilin FK506 binding protein 4 (FKBP52) as a downstream target of Hoxa10 in the periimplantation mouse uterus　T Daikoku,S Tranguch,DB Friedman,SK Das,DF Smith,SK Dey　MOLECULAR ENDOCRINOLOGY　19　3　683　2005/03
  • 　Cochaperone immunophilin FKBP52 is critical to uterine receptivity for embryo implantation　S Tranguch,J Cheung-Flynn,T Daikoku,Prapapanich, V,MB Cox,HR Xie,HB Wang,SK Das,DF Smith,SK Dey　PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　102　40　14326　2005/10
  • 　Cyclin G1 and cyclin G2 are expressed in the periimplantation mouse uterus in a cell-specific and progesterone-dependent manner: Evidence for aberrant regulation with hoxa-10 deficiency　LM Yue,T Daikoku,XN Hou,ML Li,HB Wang,H Nojima,SK Dey,SK Das　ENDOCRINOLOGY　146　5　2424　2005/05
  • 　Global gene expression analysis identifies molecular pathways distinguishing blastocyst dormancy and activation　T Hamatani,T Daikoku,HB Wang,H Matsumoto,MG Carter,MSH Ko,SK Dey　PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA　101　28　10326　2004/07
  • 　Differential expression of ezrin/radixin/moesin (ERM) and ERM-associated adhesion molecules in the blastocyst and uterus suggests their functions during implantation　H Matsumoto,T Daikoku,HB Wang,EM Sato,SK Dey　BIOLOGY OF REPRODUCTION　70　3　729　2004/03
  • 　Uterine Msx-1 and Wnt4 signaling becomes aberrant in mice with the loss of leukemia inhibitory factor or Hoxa-10: Evidence for a novel cytokine-homeobox-Wnt signaling in implantation　T Daikoku,H Song,Y Guo,A Riesewijk,S Mosselman,SK Das,SK Dey　MOLECULAR ENDOCRINOLOGY　18　5　1238　2004/05
  • 　Molecular cues to implantation　SK Dey,H Lim,SK Das,J Reese,BC Paria,T Daikoku,HB Wang　ENDOCRINE REVIEWS　25　3　341　2004/06
  • 　Expression profiles of three isoforms of inositol 1,4,5-trisphosphate receptor in brown adipose tissue of the rat　K Kajimoto,T Daikoku,N Yamazaki,H Terada,Y Shinohara　BIOCHEMICAL PHARMACOLOGY　65　6　995　2003/03
  • 　PCR-select subtraction for characterization of messages differentially expressed in brown compared with white adipose tissue　K Kajimoto,T Daikoku,F Kita,N Yamazaki,M Kataoka,Y Baba,H Terada,Y Shinohara　MOLECULAR GENETICS AND METABOLISM　80　1-2　255　2003/09
  • 　Expression of hypoxia-inducible factors in the peri-implantation mouse uterus is regulated in a cell-specific and ovarian steroid hormone-dependent manner - Evidence for differential function of HIFs during early pregnancy　T Daikoku,H Matsumoto,RA Gupta,SK Das,M Gassmann,RN Dubois,SK Dey　JOURNAL OF BIOLOGICAL CHEMISTRY　278　9　7683　2003/02
  • 　Cyclooxygenase-2 differentially directs uterine angiogenesis during implantation in mice　H Matsumoto,WG Ma,T Daikoku,XM Zhao,BC Paria,SK Das,JM Trzaskos,SK Dey　JOURNAL OF BIOLOGICAL CHEMISTRY　277　32　29260　2002/08
  • 　Expression of NAD(+)-Dependent Isocitrate Dehydrogenase in Brown Adipose Tissue　SHINOHARA Y.　Biochem Biophys Res Commun　281　3　634　2001
  • 　Dramatic enhancement of the specific expression of the heart-type fatty acid binding protein in rat brown adipose tissue by cold exposure.　Daikoku T,Shinohara Y,Shima A,Yamazaki N,Terada H　FEBS letters　410　2-3　383　1997/06
  • 　Specific elevation of transcript levels of particular protein subtypes induced in brown adipose tissue by cold exposure　Takiko Daikoku,Yasuo Shinohara,Atsushi Shima,Naoshi Yamazaki,Hiroshi Terada　Biochimica et Biophysica Acta (BBA) - Bioenergetics　1457　3　263　2000/04
  • 　Brown adipocyte-specific knockout of Bmal1 causes mild but significant thermogenesis impairment in mice.　Nazmul Hasan,Naoto Nagata,Jun-Ichi Morishige,Md Tarikul Islam,Zheng Jing,Ken-Ichi Harada,Michihiro Mieda,Masanori Ono,Hiroshi Fujiwara,Takiko Daikoku,Tomoko Fujiwara,Yoshiko Maida,Tsuguhito Ota,Shigeki Shimba,Shuichi Kaneko,Akio Fujimura,Hitoshi Ando　Molecular metabolism　49　101202　2021/07
  • 　Hypertensive disorders of pregnancy are associated with dysmenorrhea in early adulthood: A cohort study.　Midori Nakayama,Masanori Ono,Takashi Iizuka,Kyosuke Kagami,Tomoko Fujiwara,Naomi Sekizuka-Kagami,Yoshiko Maida,Takeshi Obata,Rena Yamazaki,Takiko Daikoku,Hiroshi Fujiwara　The journal of obstetrics and gynaecology research　46　11　2292　2020/11
  • 　The supression of DOCK family members by their specific inhibitors induces the cell fusion of human trophoblastic cells.　Etsuko Kiyokawa,Hiroki Shoji,Takiko Daikoku　Biochemical and biophysical research communications　529　4　1173　2020/09/03
  • 　Mucinous, endometrioid, and serous ovarian cancers with peritoneal dissemination are potent candidates for P-cadherin targeted therapy: a retrospective cohort study.　Kayo Kayahashi,Yasunari Mizumoto,Ayumi Matsuoka,Takeshi Obata,Junpei Iwadare,Mitsuhiro Nakamura,Takiko Daikoku,Hiroshi Fujiwara　BMC cancer　21　1　32　2021/01/07
  • 　Pillar[6]arene acts as a biosensor for quantitative detection of a vitamin metabolite in crude biological samples　Masaya Ueno,Takuya Tomita,Hiroshi Arakawa,Takahiro Kakuta,Tada-aki Yamagishi,Jumpei Terakawa,Takiko Daikoku,Shin-ichi Horike,Sha Si,Kenta Kurayoshi,Chiaki Ito,Atsuko Kasahara,Yuko Tadokoro,Masahiko Kobayashi,Tsutomu Fukuwatari,Ikumi Tamai,Atsushi Hirao,Tomoki Ogoshi　Communications Chemistry　3　1　2020/12　
  • 　Time-Restricted Feeding Regulates Circadian Rhythm of Murine Uterine Clock.　Takashi Hosono,Masanori Ono,Takiko Daikoku,Michihiro Mieda,Satoshi Nomura,Kyosuke Kagami,Takashi Iizuka,Rieko Nakata,Tomoko Fujiwara,Hiroshi Fujiwara,Hitoshi Ando　Current developments in nutrition　5　5　nzab064　2021/05
  • 　Sustained effect of habitual feeding time on daily rhythm of core body temperature in mice　Hitoshi Ando,Naoto Nagata,Takashi Hosono,Nazmul Hasan,Jun-ichi Morishige,Takiko Daikoku,Yoshiko Maida,Masanori Ono,Tomoko Fujiwara,Hiroshi Fujiwara　Frontiers in Nutrition　9　2022/08/22　
  • 　Laeverin/aminopeptidase Q induces indoleamine 2,3-dioxygenase-1 in human monocytes.　Takuma Suzuki,Takashi Iizuka,Kyosuke Kagami,Takeo Matsumoto,Rena Yamazaki,Takiko Daikoku,Akihito Horie,Masanori Ono,Akira Hattori,Hiroshi Fujiwara　iScience　26　9　107692　2023/09/15
  • 　Androgen promotes squamous differentiation of atypical cells in cervical intraepithelial neoplasia via an ELF3‐dependent pathway　Takeo Matsumoto,Takuma Suzuki,Mitsuhiro Nakamura,Megumi Yamamoto,Takashi Iizuka,Masanori Ono,Kyosuke Kagami,Haruki Kasama,Tatsuhito Kanda,Yuya Sakai,Junpei Iwadare,Ayumi Matsuoka,Kayo Kayahashi,Kousho Wakae,Masamichi Muramatsu,Satoru Kyo,Yasuhiko Yamamoto,Yasunari Mizumoto,Takiko Daikoku,Hiroshi Fujiwara　Cancer Medicine　12　9　10816　2023/03/23　
  • 　Immunosuppressive tumor microenvironment in Uterine Serous Carcinoma via CCL7 signal with myeloid-derived suppressor cells.　Yuka Mise,Junzo Hamanishi,Takiko Daikoku,Shiro Takamatsu,Taito Miyamoto,Mana Taki,Koji Yamanoi,Ken Yamaguchi,Masayo Ukita,Naoki Horikawa,Kaoru Abiko,Ryusuke Murakami,Yoko Furutake,Yuko Hosoe,Jumpei Terakawa,Masahiro Kagabu,Tamotsu Sugai,Mitsumasa Osakabe,Hiroshi Fujiwara,Noriomi Matsumura,Masaki Mandai,Tsukasa Baba　Carcinogenesis　43　7　647　2022/03/30
  • 　AVP neurons act as the primary circadian pacesetter cells in vivo　Yusuke Tsuno,Yubo Peng,Shin-ichi Horike,Kanato Yamagata,Mizuki Sugiyama,Takahiro J. Nakamura,Takiko Daikoku,Takashi Maejima,Michihiro Mieda　bioRxiv　2022/08/05
  • 　Cell Type-Specific Genetic Manipulation and Impaired Circadian Rhythms in Vip tTA Knock-In Mice.　Yubo Peng,Yusuke Tsuno,Ayako Matsui,Yuichi Hiraoka,Kohichi Tanaka,Shin-Ichi Horike,Takiko Daikoku,Michihiro Mieda　Frontiers in physiology　13　895633　2022
  • 　Uterine Deletion of Bmal1 Impairs Placental Vascularization and Induces Intrauterine Fetal Death in Mice　Masanori Ono,Natsumi Toyoda,Kyosuke Kagami,Takashi Hosono,Takeo Matsumoto,Shin-ichi Horike,Rena Yamazaki,Mitsuhiro Nakamura,Yasunari Mizumoto,Tomoko Fujiwara,Hitoshi Ando,Hiroshi Fujiwara,Takiko Daikoku　International Journal of Molecular Sciences　23　14　2022/07　
  • 　FOXP4 inhibits squamous differentiation of atypical cells in cervical intraepithelial neoplasia via an ELF3‐dependent pathway　Takeo Matsumoto,Takashi Iizuka,Mitsuhiro Nakamura,Takuma Suzuki,Megumi Yamamoto,Masanori Ono,Kyosuke Kagami,Haruki Kasama,Kousho Wakae,Masamichi Muramatsu,Shin‐ichi Horike,Satoru Kyo,Yasuhiko Yamamoto,Yasunari Mizumoto,Takiko Daikoku,Hiroshi Fujiwara　Cancer Science　113　10　3376　2022/08　
  • 　Kif26b contributes to the progression of interstitial fibrosis via migration and myofibroblast differentiation in renal fibroblast.　Yuta Yamamura,Yasunori Iwata,Kengo Furuichi,Takahiro Kato,Naoki Yamamoto,Keisuke Horikoshi,Hisayuki Ogura,Koichi Sato,Megumi Oshima,Shiori Nakagawa,Taro Miyagawa,Shinji Kitajima,Tadashi Toyama,Akinori Hara,Norihiko Sakai,Miho Shimizu,Shinichi Horike,Takiko Daikoku,Ryuichi Nishinakamura,Takashi Wada　FASEB journal : official publication of the Federation of American Societies for Experimental Biology　36　11　e22606　2022/11
  • 　The Circadian Clock, Nutritional Signals and Reproduction: A Close Relationship.　Masanori Ono,Hitoshi Ando,Takiko Daikoku,Tomoko Fujiwara,Michihiro Mieda,Yasunari Mizumoto,Takashi Iizuka,Kyosuke Kagami,Takashi Hosono,Satoshi Nomura,Natsumi Toyoda,Naomi Sekizuka-Kagami,Yoshiko Maida,Naoaki Kuji,Hirotaka Nishi,Hiroshi Fujiwara　International journal of molecular sciences　24　2　2023/01/12
  • 　BMAL1 positively correlates with genes regulating steroidogenesis in human luteinized granulosa cells.　Tomomi Kawamura,Yidan Dai,Masanori Ono,Takayuki Kikuchi,Akina Yamanaka,Keiko Ueno,Junya Kojima,Tomoko Fujiwara,Takiko Daikoku,Yoshiko Maida,Hitoshi Ando,Hiroshi Fujiwara,Naoaki Kuji,Hirotaka Nishi　Reproduction (Cambridge, England)　167　2　2024/02/01
  • 　Uterine epithelial Gp130 orchestrates hormone response and epithelial remodeling for successful embryo attachment in mice.　Takafumi Namiki,Jumpei Terakawa,Harumi Karakama,Michiko Noguchi,Hironobu Murakami,Yoshinori Hasegawa,Osamu Ohara,Takiko Daikoku,Junya Ito,Naomi Kashiwazaki　Scientific reports　13　1　854　2023/01/16
  • 　Mitochondrial one-carbon metabolic enzyme MTHFD2 facilitates mammary gland development during pregnancy.　Yuming Wang,Tsunaki Hongu,Tatsunori Nishimura,Yasuto Takeuchi,Hiroshi Takano,Takiko Daikoku,Ryoji Yao,Noriko Gotoh　Biochemical and biophysical research communications　674　183　2023/09/24
  • 　In vivo recording of suprachiasmatic nucleus dynamics reveals a dominant role of arginine vasopressin neurons in circadian pacesetting　Yusuke Tsuno,Yubo Peng,Shin-ichi Horike,Mohan Wang,Ayako Matsui,Kanato Yamagata,Mizuki Sugiyama,Takahiro J. Nakamura,Takiko Daikoku,Takashi Maejima,Michihiro Mieda　PLOS Biology　21　8　2023/08/29
  • 　Spheroid formation induces chemokine production in trophoblast-derived Swan71 cells.　Tatsuhito Kanda,Kyosuke Kagami,Takashi Iizuka,Haruki Kasama,Takeo Matsumoto,Yuya Sakai,Takuma Suzuki,Megumi Yamamoto,Ayumi Matsuoka,Rena Yamazaki,Akira Hattori,Akihito Horie,Takiko Daikoku,Masanori Ono,Hiroshi Fujiwara　American journal of reproductive immunology (New York, N.Y. : 1989)　90　2　e13752　2023/08
  • 　Desynchronization between food intake and light stimulations induces uterine clock quiescence in female mice.　Satoshi Nomura,Takashi Hosono,Masanori Ono,Takiko Daikoku,Michihiro Mieda,Kyosuke Kagami,Takashi Iizuka,Yuchen Chen,Yifan Shi,Jun-Ichi Morishige,Tomoko Fujiwara,Hiroshi Fujiwara,Hitoshi Ando　The Journal of nutrition　153　8　2283　2023/06/17
  • 　A novel oral inhibitor for one-carbon metabolism and checkpoint kinase 1 inhibitor as a rational combination treatment for breast cancer.　Jin Lee,Xiaoxi Chen,Yuming Wang,Tatsunori Nishimura,Mengjiao Li,Satoko Ishikawa,Takiko Daikoku,Junya Kawai,Arinobu Tojo,Noriko Gotoh　Biochemical and biophysical research communications　584　7　2021/12/20
  • 　Versican provides the provisional matrix for uterine spiral artery dilation and fetal growth.　Yusuke Sagae,Akihito Horie,Akihiro Yanai,Tsutomu Ohara,Baku Nakakita,Yoshimi Kitawaki,Asuka Okunomiya,Hirohiko Tani,Ken Yamaguchi,Junzo Hamanishi,John P Lydon,Takiko Daikoku,Hideto Watanabe,Masaki Mandai　Matrix biology : journal of the International Society for Matrix Biology　115　16　2022/11/21
  • 　Uterine epithelial deletion of Gp130 shows embryo implantation failure in mice　NAMIKI Takafumi,KARAKAMA Harumi,TERAKAWA Jumpei,DAIKOKU Takiko,KAGEYAMA Athuko,HASEGAWA Yoshinori,OHARA Osamu,ITO Junya,KASHIWAZAKI Naomi　The Journal of Reproduction and Development Supplement　114　AW-4　2021

Conference Presentations

Others

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「閉経後ホルモン依存性子宮体癌の発症・進展の新たな分子機構 −男性ホルモン作用の解析と臨床応用−」(2020-2022)　
○「子宮選択的Pten変異による体癌自然発症マウスを用いた増悪因子と作用機序の解析」(2016-2018)　
○「新たな子宮肉腫マウスモデルを用いた肉腫化抑制因子の同定と新規分子標的治療への応用」(2018-2019)　
○2022「子宮がん自然発症マウスモデルを用いたがん発生を制御する上皮・間質の相互応答の解明」(2020-2022)　
○2022「乳癌患者におけるタモキシフェンによる子宮内膜器質性変化の解析と妊孕性に及ぼす影響」(2020-2022)　
○2021「がん自然発症マウスを用いた末梢概日リズム異常によるがん発生・進展誘導機構の解析」(2020-2021)　
○「凝固系をターゲットとした卵巣癌腹膜播種機序の解明と治療戦略に関する基礎的研究」(2019-2021)　
○「生後早期の母子関係を評価する新規バイオマーカーの開発 -発達障害回避を目指して-」(2019-2020)　
○「概日リズムによる子宮収縮制御機構に着目した産婦人科疾患予防法の探索」(2019-2021)　
○「代謝酵素ゲノム編集による食道扁平上皮の易発がん状態誘発の試み」(2018-2019)　
○「SWATH 解析法を用いた着床前胚に対する母体生殖管の生理的応答機構の解明」(2017-2019)　
○「癌特異的プロモーターと磁性ナノ粒子を応用した婦人科癌における末梢血中主要 細胞解析」(2017-2019)　
○「低エストロゲン環境に着目した閉経期における子宮体癌発症機序の解明」(2017-2018)　
○「概日時計の乱れが誘発する若年女性の生殖機能障害の実態とその機序の解析ー朝食欠食とダイエットに着目してー」(2018-2020)　
○「胚シグナルによる免疫寛容誘導機構に基づく胎児・胎盤循環幹細胞の解析」(2017-2019)　
○「絨毛性希少がん胎盤部トロホブラスト腫瘍(PSTT)の有効な診断及び治療法の開発」(2017-2019)　
○「ヒト胚着床に関わるversicanの機能解析」(2017-2019)　
○「乳癌患者におけるタモキシフェン投与の子宮内膜着床能に及ぼす影響と作用機序の解明」(2017-2019)　
○「卵管上皮に対する月経と排卵に伴う液性因子の発がん誘導作用の解析」(2016-2018)　
○「免疫系を介した胚着床誘導機構の解明-胚シグナルの同定と機能解析-」(2017-2019)　
○「ヒト胚着床に関わるversicanの機能解析」　
○「STAT1標的による、子宮体部漿液性癌に対する有効治療の開発 」　
○「乳癌患者におけるタモキシフェン投与の子宮内膜着床能に及ぼす影響と作用機序の解析」　
○「SWATH解析法を用いた着床前胚に対する母体生殖管の生理的応答機構の解明」　
○「p53変異と閉経後のエストロゲン減少に着目したType２体癌モデルの作成と解析 」　
○「注意欠陥多動性障害はどのように発症するのか：クレアチンを標的とした機序の検討」(2015-2017)　
○「胚由来の胚着床誘導因子（胚シグナル）の同定と臨床応用への試み」(2014-2016)　
○「乳癌患者におけるタモキシフェンによる子宮内膜着床能向上と卵巣保護作用の解析」(2023-2025)　
○「ゲノム多様性獲得による子宮内膜胚着床環境整備と発癌抑制機構解明に向けた基礎研究」(2022-2023)　
○「フィブリン形成を介した腹水卵巣癌細胞の新しいTME形成機序」(2022-2024)　
○「脈管内がん幹細胞の胚シグナル分子による微小環境形成機構とそれを標的にした治療戦略」(2022-2025)　
○「栄養膜細胞特異抗原を用いた末梢血循環腫瘍細胞の検出と新規転移抑制治療法の開発」(2021-2023)　
○「末梢体内時計障害の本態の解明と治療基盤の確立」(2021-2023)　
○「新規胚シグナルlaeverinの幹細胞と免疫システムに対する作用の解明と臨床応用」(2021-2024)　

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

○Basic Medical and Pharmaceutical Sciences Rotation Practice（Course in Biomedical Science）ⅠＡ(2023)
○Laboratory animal science and stem cell biology(2023)
○Basic Medical and Pharmaceutical Sciences Rotation Practice（Course in Biomedical Science）ⅠＡ(2023)
○Basic Medical and Pharmaceutical Sciences Rotation Practice（Course in Biomedical Science）ⅠＡ(2023)
○Laboratory animal science and stem cell biology(2023)
○Laboratory animal science and stem cell biology(2023)
○Laboratory animal science and stem cell biology(2023)
○Laboratory animal science and stem cell biology(2022)
○Laboratory animal science and stem cell biology(2022)
○Laboratory animal science and stem cell biology(2022)
○Laboratory animal science and stem cell biology(2022)
○Laboratory animal science and stem cell biology(2021)
○Laboratory animal science and stem cell biology(2020)
○Laboratory animal science and stem cell biology(2019)
○Laboratory animal science and stem cell biology(2018)
○Laboratory animal science and stem cell biology(2017)
○Laboratory animal science and stem cell biology(2016)

Classes (Graduate Schools)

○Mouse Embryo Manipulation Basic Course(2023)
○Gene Engineering Basic Course(2023)
○Seminar on Advanced Medical Science(2023)
○Laboratory Rotation I(2023)
○Laboratory Rotation I(2023)
○Laboratory Rotation Ｉ(2023)
○Laboratory RotationⅠ(2023)
○Laboratory RotationⅠ(2023)
○Laboratory RotationⅡ(2023)
○Laboratory RotationⅠ(2023)
○Seminar on Animal Experimentation(2023)
○Laboratory RotationⅠ(2023)
○Laboratory RotationⅠ(2023)
○Laboratory Rotation I(2023)
○Laboratory Rotation I(2023)
○Laboratory Rotation I(2023)
○Laboratory Rotation I(2023)
○Mouse Embryo Manipulation Basic Course(2022)
○Mouse Embryo Manipulation Basic Course(2022)
○Gene Engineering Basic Course(2022)
○Seminar on Advanced Medical Science(2022)
○Seminar on Advanced Medical Science(2022)
○Gene Engineering Basic Course(2022)
○Seminar on Animal Experimentation(2022)
○Gene Engineering Basic Course(2021)
○Seminar on Advanced Medical Science(2021)
○Seminar on Animal Experimentation(2021)
○Mouse Embryo Manipulation Basic Course(2021)
○Gene Engineering Basic Course(2020)
○Seminar on Advanced Medical Science(2020)
○Mouse Embryo Manipulation Basic Course(2020)
○Advanced Transgenic Animal Science(2020)
○Advanced Transgenic Animal Science(2020)
○Seminar on Advanced Medical Science(2020)
○Introduction to Basic Medical Science(2020)
○Gene Engineering Basic Course(2020)
○Mouse Embryo Manipulation Basic Course(2020)
○Seminar on Animal Experimentation(2020)
○Seminar on Animal Experimentation(2020)
○Seminar on Advanced Medical Science(2019)
○Mouse Embryo Manipulation Basic Course(2019)
○Seminar on Animal Experimentation(2019)
○Seminar on Animal Experimentation(2019)
○Mouse Embryo Manipulation Basic Course(2019)
○Seminar on Advanced Medical Science(2019)
○Advanced Transgenic Animal Science(2019)
○Advanced Transgenic Animal Science(2019)
○Introduction to Basic Medical Science(2019)
○Gene Engineering Basic Course(2019)
○Gene Engineering Basic Course(2019)
○Gene Engineering Basic Course(2018)
○Introduction to Basic Medical Science(2018)
○Mouse Embryo Manipulation Basic Course(2018)
○Seminar on Advanced Medical Science(2018)
○Advanced Transgenic Animal Science(2018)
○Seminar on Advanced Medical Science(2018)
○Seminar on Animal Experimentation(2018)
○Advanced Transgenic Animal Science(2018)
○Mouse Embryo Manipulation Basic Course(2018)
○Gene Engineering Basic Course(2018)
○Seminar on Animal Experimentation(2018)
○Gene Engineering Basic Course(2017)
○Advanced Transgenic Animal Science(2017)
○Advanced Transgenic Animal Science(2017)
○Advanced Transgenic Animal Science(2017)
○Seminar on Advanced Medical Science(2017)
○Mouse Embryo Manipulation Basic Course(2017)
○Gene Engineering Basic Course(2017)
○Mouse Embryo Manipulation Basic Course(2017)
○Seminar on Advanced Medical Science(2017)
○Seminar on Animal Experimentation(2017)
○Introduction to Basic Medical Science(2016)
○Mouse Embryo Manipulation Basic Course(2016)
○Advanced Transgenic Animal Science(2016)
○Advanced Transgenic Animal Science(2016)
○Seminar on Animal Experimentation(2016)
○Advanced Transgenic Animal Science(2016)
○Gene Engineering Basic Course(2016)
○Mouse Embryo Manipulation Basic Course(2016)
○Gene Engineering Basic Course(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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