Jump to contents

Researcher Information

last modified：2024/01/08

Assistant Professor　HIROSHI Ishii

Mail

Faculty, Affiliation

Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences　Neuroanatomy
Assistant Professor

College and School Educational Field

Division of Medical Sciences, Graduate School of Medical Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences
School of Medicine, College of Medical, Pharmaceutical and Health Sciences
School of Medicine, College of Medical, Pharmaceutical and Health Sciences
School of Medicine, College of Medical, Pharmaceutical and Health Sciences
School of Medicine, College of Medical, Pharmaceutical and Health Sciences

Laboratory

Department of Neuroanatomy

Academic Background

【Academic background(Doctoral/Master's Degree)】
1994-1998　A.B., Tohoku University (Aeronautics & Astronautics)　　　　　　　　　　　2001-2005　M.D., Osaka University　 　　　　　　 　 　　　　　　　　　　　　　　 　　 2007-2011　Ph.D., Chiba University (Neuroscience)　 　　　　　　 　 　　　　　　　　　　Doctor　of　Philosophy　2011　Completed
【Academic background(Bachelor's Degree)】
Osaka University　200503
【Degree】
Doctor of Medicine & Doctor of Philosophy

Career

Columbia University in the City of New York, The College of Physicians and Surgeons, The Columbia Center for Translational Immunology　The Uehara Memorial Research Fellow　　 (2013/09/01-2015/07/31)

Year & Month of Birth

Academic Society

Society for Neuroscience (USA)
The Japan Neuroscience Society
The Japanese Association of Anatomists

Award

○The General Insurance Association of Japan, Research Grant for Treatment & Management of Traffic Accident (2016/09/16)
○The Uehara Memorial Foundation Research Fellowship (2014/03/11)
○The Yasuda Memorial Medical Foundation Research Fellow (2013/12/14)

Specialities

Neuroimmunology, neurosurgery, and stem cell biology

Speciality Keywords

Evolution and neuro-regeneration, neuro-immune association; subarachnoid hemorrhage (SAH), cerebral vasospasm; spinal cord injury (SCI), unfolded protein response-induced inflammation, microglia

Research Themes

Elucidation of mechanism underlying pathophysiology of spinal cord injury in terms of unfolded stress response-induced inflammation.

Books

  • 　ISHII, Hiroshi; YAMASHITA, Toshihide; Editorial board member: YUZAKI, Michisuke　DOI：10.14931/bsd.489　Heat shock protein, Brain Science Dictionary　The Japan Neuroscience Society, Brain Science Dictionary Editorial Borad　2012/02

Papers

  • 　CD150high Bone Marrow Tregs Maintain Hematopoietic Stem Cell Quiescence and Immune Privilege via Adenosine.　Hirata Y, Furuhashi K, Ishii H, Li HW, Pinho S, Ding L, Robson SC, Frenette PS, Fujisaki J　　　　　　Cell Stem Cell, Cell Press　22　3　445-453　2018/03/01　
  • 　N-myc downstream-regulated gene 2 protects blood-brain barrier integrity following cerebral ischemia.　　　　Takarada-Iemata M, Yoshikawa A, Ta HM, Okitani N, Nishiuchi T, Aida Y, Kamide T, Hattori T, Ishii H, Tamatani T, Le TM, Roboon J, Kitao Y, Matsuyama T, Nakada M, Hori O.　Glia, Wiley Online Library, Epub ahead of print. 　　　　　北國新聞、QLifePro 医療ニュースで取り上げられた。　2018/02/24　
  • 　Ndrg2 deficiency ameliorates neurodegeneration in experimental autoimmune encephalomyelitis.　Le TM, Takarada-Iemata M, Ta HM, Roboon J, Ishii H, Tamatani T, Kitao Y, Hattori T, Hori O.　J Neurochem, The International Society for Neurochemistry, in press.　2018/02/19　
  • 　CD38 positively regulates postnatal development of astrocytes cell-autonomously and oligodendrocytes non-cell-autonomously.　Hattori T, Kaji M, Ishii H, Jureepon R, Takarada-Iemata M, Minh Ta H, Manh Le T, Konno A, Hirai H, Shiraishi Y, Ozaki N, Yamamoto Y, Okamoto H, Yokoyama S, Higashida H, Kitao Y, Hori O.　Glia, Wiley Periodicals, Epub ahead of print. 　　　北國新聞、Yahooニュース、中日新聞、QLifePro 医療ニュース、日本の研究.comで取り上げられた。　2017/03/13　
  • 　Atf6α deficiency suppresses microglial activation and ameliorates pathology of experimental autoimmune encephalomyelitis.　Ta HM, Le TM, Ishii H, Takarada-Iemata M, Hattori T, Hashida K, Yamamoto Y, Mori K, Takahashi R, Kitao Y, Hori O.　J Neurochem, The International Society for Neurochemistry, Epub ahead of print. 　表紙を飾った。筆頭著者は第38回日本生物学的精神医学会・第59回日本神経化学会大会 合同年会（2016年9月、福岡）にて優秀発表者賞を受賞した。　2016/07/18　

show all

  • 　MHC class I expression by donor hematopoietc stem cells is required to inhibit NK cell attack in allogeneic, but not syngeneic recipient mice.　Hirata Y, Li H, Takahashi K, Ishii H, Sykes M, Fujisaki J.　PLoS One, Public Library Science, e0141785　2015　
  • 　ifn-γ-dependent secretion of IL-10 from Th1 cells and microglia/macrophages contributes to functional recovery after spinal cord injury.　Ishii H, Tanabe S, Ueno M, Kubo T, Kayama H, Serada S, Fujimoto M, Takeda K, Naka T, and Yamashita T.　Cell Death and Disease, Nature Publishing Group, 4:e710　2013/07/04　
  • 　Adoptive transfer of Th1-conditioned lymphocytes promotes axonal remodeling and functional recovery after spinal cord injury.　Ishii H, Jin X, Ueno M, Tanabe S, Kubo T, Serada S, Naka T, Yamashita T.　Cell Death and Disease, Nature Publishing Group, 3:e363　2012/08/09　
  • 　Temporal changes in cell marker expression and cellular infiltration in a controlled cortical impact model in adult male C57BL/6 mice.　Jin X, Ishii H, Bai Z, Itokazu T, Yamashita T.　PLoS One, Public Library Science, 7:e41892　2012/07/24　
  • 　Th1 cells promote neurite outgrowth from cortical neurons via a mechanism dependent on semaphorins.　Ishii H, Kubo T, Kumanogoh A, Yamashita T.　Biochem Biophys Res Commun, Elsevier, 402:168-172　2010/10/12　
  • 　Evaluation of quality of life in patients receiving palliative care. 　Ishii H, Ikeoka K, Nakauchi C, Yamamoto M, Yano M, Yagi Y, Fujita H, Adachi T, Morimoto K, Mandai T.　Quality of Life Journal, Japan Society for Quality of Life, 5(1):41-45 (Japanese)　2004
  • 　QOL change in patients after renal transplantation.　Ikeoka K, Ishii H, Nakauchi C, Yano M, Kakuta Y, Takahara S, Fujita H, Adachi K, Morimoto K, Mandai T. 　Quality of Life Journal, Japan Society for Quality of Life, 4:71-77 (Japanese)　2004
  • 　QOL change after promotion of women's health with exercise therapy.　Nakauchi C, Ishii H, Ikeoka K, Yano M, Shinagawa Y, Fujita H, Adachi T, Mandai T.　Quality of Life Journal, Japan Society for Quality of Life, 5:47 (Japanese)　2004

Conference Presentations

  • Transfer of Th1 cells promotes recovery from spinal cord injury. (conference：FASEB Summer Conference on Translational Neuroimmunology: From Mechanisms to Therapeutics, Carefree, Arizona, USA)(2012/07/31)
  • Implantation of Th1 cells ameliorates recovery after spinal cord injury. (conference：Neuro2010, The 33rd Annual Meeting of the Japan Neuroscience Society, Kobe, Japan)(2010/09/02)
  • Case study of herpes simplex encephalitis that developed with symptom of afebrile headache. (conference：Forum of Mie Medical Complex, Post Graduate Medical Training)(2007/01)

Others

Arts and Fieldwork

Patent

○COMPOSITION FOR TREATING CENTRAL NERVE DAMAGE, AND USE THEREOF, WO125531 (publish date：2013/08/29)
○Composition for Treating Central Nerve Damage, and use thereof. Pub. No. 2015-091761 Japan Patent (publish date：2015/05/14)

Theme to the desired joint research

○1. Neuro-regeneration and immunology 2. Evolution and CNS diseases; I am skilled in analysis of the central nervous system using flow cytometry/cell sorter. I am look forward to collaborating with scientists/clinicians who are interested in similar theme to mine and, dedicated in or interested in live imaging with techniques such as multi-photon excitation microscopy.

Grant-in-Aid for Scientific Research

○Fund for the Promotion of Joint International Research (Fostering Joint International Research (A))「Developing novel therapy for subarachnoid hemorrhage」(2018-2021)　
○Grant-in-Aid for Scientific Research (C)「Elucidation of molecular mechanisms underlying vasospasm after subarachnoid hemorrhage.」(2017-2019)　
○Grant-in-Aid for Young Scientists (Start-up)「Functions of adoptive immune system after injury of the central nervous system and immunomodulatory treatment」(2012-2013)　

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

○Freshman Seminar I(2017)
○Embryology(2017)
○Neuroanatomy(2017)
○Neuroanatomy(2016)
○Human Embryology(2016)

Classes (Graduate Schools)

○Principles of Anatomy(2017)
○Molecular Targeting in the Central Nervous System(2017)
○Molecular Targeting in the Central Nervous System(2017)
○Molecular Targeting in the Central Nervous System(2016)
○Molecular Targeting in the Central Nervous System(2016)
○Principles of Anatomy(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

To Page Top