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last modified：2025/04/04
Professor FUJINAGA, Yukako
Faculty, Affiliation
Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences
College and School Educational Field
Laboratory
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Papers
- Uptake of Botulinum Neurotoxin in the Intestine Yukako Fujinaga,Yo Sugawara,Takuhiro Matsumura BOTULINUM NEUROTOXINS 364 45 2013
- Alcohol consumption promotes the intestinal translocation of Streptococcus suis infections T. Nakayama,D. Takeuchi,T. Matsumura,Y. Akeda,Y. Fujinaga,K. Oishi Microbial Pathogenesis 65 14 2013/12
- Crystal Structure of Clostridium botulinum Whole Hemagglutinin Reveals a Huge Triskelion-shaped Molecular Complex Sho Amatsu,Yo Sugawara,Takuhiro Matsumura,Kengo Kitadokoro,Yukako Fujinaga JOURNAL OF BIOLOGICAL CHEMISTRY 288 49 35617 2013/12
- Collagen adhesion gene is associated with blood stream infections caused by methicillin-resistant Staphylococcus aureus. Iwata Y,Satou K,Furuichi K,Yoneda I,Matsumura T,Yutani M,Fujinaga Y,Hase A,Morita H,Ohta T,Senda Y,Sakai-Takemori Y,Wada T,Fujita S,Miyake T,Yasuda H,Sakai N,Kitajima S,Toyama T,Shinozaki Y,Sagara A,Miyagawa T,Hara A,Shimizu M,Kamikawa Y,Ikeo K,Shichino S,Ueha S,Nakajima T,Matsushima K,Kaneko S,Wada T International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 91 22 2019/11
- Functional Analysis of Botulinum Hemagglutinin (HA). Takuhiro Matsumura,Yukako Fujinaga Methods in molecular biology (Clifton, N.J.) 2132 191 2020
- Fully Human Monoclonal Antibodies Effectively Neutralizing Botulinum Neurotoxin Serotype B. Takuhiro Matsumura,Sho Amatsu,Ryo Misaki,Masahiro Yutani,Anariwa Du,Tomoko Kohda,Kazuhito Fujiyama,Kazuyoshi Ikuta,Yukako Fujinaga Toxins 12 5 2020/05/07
- Effects of antibiotics on the viability of and toxin production by Clostridium botulinum. Masahiro Yutani,Takuhiro Matsumura,Yukako Fujinaga Microbiology and immunology 65 10 432 2021/07/05
- Membrane Vesicles Derived From Clostridium botulinum and Related Clostridial Species Induce Innate Immune Responses via MyD88/TRIF Signaling in vitro Nobuhide Kobayashi,Kimihiro Abe,Sachiyo Akagi,Mayu Kitamura,Yoshitake Shiraishi,Aki Yamaguchi,Masahiro Yutani,Sho Amatsu,Takuhiro Matsumura,Nobuhiko Nomura,Noriyuki Ozaki,Nozomu Obana,Yukako Fujinaga Frontiers in Microbiology 13 2022/02/03
- Oral Corticosteroids Impair Mucin Production and Alter the Posttransplantation Microbiota in the Gut. Hirofumi Okafuji,Noriho Iida,Kazuya Kitamura,Jun Seishima,Ziyu Wang,Masahiro Yutani,Takatoshi Yoshio,Taro Yamashita,Yoshio Sakai,Masao Honda,Tatsuya Yamashita,Yukako Fujinaga,Reiko Shinkura,Yasuhito Hamaguchi,Eishiro Mizukoshi,Shuichi Kaneko Digestion 1 2022/02/18
- Botulinum Hemagglutinin: Critical Protein for Adhesion and Absorption of Neurotoxin Complex in Host Intestine. Sho Amatsu,Yukako Fujinaga Methods in molecular biology (Clifton, N.J.) 2132 183 2020
- [Molecular targets of bacterial effectors and toxins that underlie vulnerability to diseases]. Takeshi Shimizu,Yukako Fujinaga,Akiko Takaya,Hiroshi Ashida,Toshio Kodama,Masanori Hatakeyama Nihon saikingaku zasshi. Japanese journal of bacteriology 70 2 319 2015
- Translocation and dissemination of botulinum neurotoxin from the intestinal tract Yukako Fujinaga,Michel R. Popoff Toxicon 147 13 2018/06/01
- Botulinum neurotoxin X lacks potency in mice and in human neurons Brieana M. Gregg,Takuhiro Matsumura,Travis G. Wentz,William H. Tepp,Marite Bradshaw,Pål Stenmark,Eric A. Johnson,Yukako Fujinaga,Sabine Pellett mBio 2024/02/13
- Multivalency effects of hemagglutinin component of type B botulinum neurotoxin complex on epithelial barrier disruption Sho Amatsu,Takuhiro Matsumura,Masahiro Yutani,Yukako Fujinaga Microbiology and Immunology 62 2 80 2018/02/01
- Patient-derived Enterococcus faecium with inflammatory genotypes promote colitis Ziyu Wang,Noriho Iida,Jun Seishima,Hirofumi Okafuji,Masahiro Yutani,Yukako Fujinaga,Yusuke Hashimoto,Haruyoshi Tomita,Eishiro Mizukoshi,Shuichi Kaneko Journal of Gastroenterology 2022/07/26
- Growth prolongation of human induced pluripotent stem cell aggregate in three-dimensional suspension culture system by addition of botulinum hemagglutinin Riku Yamamoto,Ryo Sakakibara,Mee-Hae Kim,Yukako Fujinaga,Masahiro Kino-oka Journal of Bioscience and Bioengineering 137 2 141 2023/12
- Adult-onset botulism in a Japanese woman with prolonged spore excretion Keigo Kihara,Yuta Kajiyama,Yasuyoshi Kimura,Shuhei Okazaki,Naoya Esa,Ryosuke Nobe,Kentaro Shimizu,Kiyoshi Ohno,Daisuke Motooka,Takuhiro Matsumura,Takeshi Shimazu,Shota Nakamura,Yukako Fujinaga,Hideki Mochizuki Journal of Infection and Chemotherapy 29 12 1172 2023/12
- Chronic liver disease enables gut Enterococcus faecalis colonization to promote liver carcinogenesis. Noriho Iida,Eishiro Mizukoshi,Tatsuya Yamashita,Masahiro Yutani,Jun Seishima,Ziyu Wang,Kuniaki Arai,Hikari Okada,Taro Yamashita,Yoshio Sakai,Yusuke Masuo,Rina Agustina,Yukio Kato,Yukako Fujinaga,Masanobu Oshima,Masao Honda,François Lebreton,Michael S Gilmore,Shuichi Kaneko Nature cancer 2 10 1039 2021/10
- Toxins 2017 conference in Madrid Alberto Albanese,Francisco Cardoso,Yukako Fujinaga,Joseph Jankovic,Andreas Rummel,Giampietro Schiavo Toxicon 147 1 2018/06/01
- Molecular engineering of a minimal E-cadherin inhibitor protein derived from Clostridium botulinum hemagglutinin. Sho Amatsu,Takuhiro Matsumura,Masahiko Zuka,Yukako Fujinaga The Journal of biological chemistry 299 3 102944 2023/01/24
- Rare toxin A-negative and toxin B-positive strain of Clostridioides difficile from Japan lacking a complete tcdA gene Yukiko Takemori-Sakai,Kenji Satou,Yasuko Senda,Youko Nakamura,Hatsumi Otani,Akiko Maekawa,Hiroyasu Oe,Megumi Oshima,Shiori Yoneda-Nakagawa,Taro Miyagawa,Koichi Sato,Hisayuki Ogura,Mika Mori,Taizo Wada,Yoshio Sakai,Masahiro Yutani,Takuhiro Matsumura,Yukako Fujinaga,Toshifumi Gabata,Takashi Wada,Yasunori Iwata Journal of Infection and Chemotherapy 28 5 651 2022/05
- Neutralization mechanism of human monoclonal antibodies against type B botulinum neurotoxin Takuhiro Matsumura,Mayu Kitamura,Sho Amatsu,Aki Yamaguchi,Nobuhide Kobayashi,Masahiro Yutani,Yukako Fujinaga Microbiology and Immunology 2024/09/06
- Development and Optimization of Genetic Manipulation Systems in Group I Clostridium botulinum Sho Amatsu,Kazuki Saito,Shigeru Miyata,Masahiko Zuka,Hirofumi Nariya,Yukako Fujinaga 2024/06/05
- Maintenance of an undifferentiated state of human-induced pluripotent stem cells through botulinum hemagglutinin-mediated regulation of cell behavior. Shuzui E,Kim MH,Azuma K,Fujinaga Y,Kino-Oka M Journal of bioscience and bioengineering 127 6 744 2019/06
- Botulinum hemagglutinin-mediated selective removal of cells deviating from the undifferentiated state in hiPSC colonies Mee-Hae Kim,Yo Sugawara,Yukako Fujinaga,Masahiro Kino-oka SCIENTIFIC REPORTS 7 1 93 2017/03
- Gut-derived Enterococcus faecium from ulcerative colitis patients promotes colitis in a genetically susceptible mouse host. Jun Seishima,Noriho Iida,Kazuya Kitamura,Masahiro Yutani,Ziyu Wang,Akihiro Seki,Taro Yamashita,Yoshio Sakai,Masao Honda,Tatsuya Yamashita,Takashi Kagaya,Yukihiro Shirota,Yukako Fujinaga,Eishiro Mizukoshi,Shuichi Kaneko Genome biology 20 1 252 2019/11/25
- Clostridium botulinum type C hemagglutinin affects the morphology and viability of cultured mammalian cells via binding to the ganglioside GM3 Yo Sugawara,Masao Iwamori,Takuhiro Matsumura,Masahiro Yutani,Sho Amatsu,Yukako Fujinaga FEBS JOURNAL 282 17 3334 2015/09
- Functional Dissection of the Clostridium botulinum Type B Hemagglutinin Complex: Identification of the Carbohydrate and E-Cadherin Binding Sites Yo Sugawara,Masahiro Yutani,Sho Amatsu,Takuhiro Matsumura,Yukako Fujinaga PLOS ONE 9 10 e111170 2014/10
- Botulinum toxin A complex exploits intestinal M cells to enter the host and exert neurotoxicity Takuhiro Matsumura,Yo Sugawara,Masahiro Yutani,Sho Amatsu,Hideo Yagita,Tomoko Kohda,Shin-Ichi Fukuoka,Yutaka Nakamura,Shinji Fukuda,Koji Hase,Hiroshi Ohno,Yukako Fujinaga NATURE COMMUNICATIONS 6 6255 2015/02
- Membrane Vesicles Derived From Clostridium botulinum and Related Clostridial Species Induce Innate Immune Responses via MyD88/TRIF Signaling in vitro. Kobayashi N, Abe K, Akagi S, Kitamura M, Shiraishi Y, Yamaguchi A, Yutani M, Amatsu S, Matsumura T, Nomura N, Ozaki N, Obana N, Fujinaga Y. Front Microbiol. 13 720308 2022/02/03
- Oral Corticosteroids Impair Mucin Production and Alter the Posttransplantation Microbiota in the Gut. Okafuji H, Iida N, Kitamura K, Seishima J, Wang Z, Yutani M, Yoshio T, Yamashita T, Sakai Y, Honda M, Yamashita T, Fujinaga Y, Shinkura R, Hamaguchi Y, Mizukoshi E, Kaneko S. Digestion 1-18 2022/02/18
- Molecular engineering of a minimal E-cadherin inhibitor protein derived from Clostridium botulinum hemagglutinin. Amatsu S, Matsumura T, Zuka M, Fujinaga Y. .J Biol Chem. 299 3 102944 2023/01/25
- Chronic liver disease enables gut Enterococcus faecalis colonization to promote liver carcinogenesis. Iida N, Mizukoshi E, Yamashita T, Yutani M, Seishima J, Wang Z, Arai K, Okada H, Yamashita T, Sakai Y, Masuo Y, Agustina R, Kato Y, Fujinaga Y, Oshima M, Honda M, Lebreton F, Gilmore MS, Kaneko S Nat.Cancer 2 10 1039-1054 2021/09/27
- Rare toxin A-negative and toxin B-positive strain of Clostridioides difficile from Japan lacking a complete tcdA gene. Takemori-Sakai Y, Satou K, Senda Y, Nakamura Y, Otani H, Maekawa A, Oe H, Oshima M, Yoneda-Nakagawa S, Miyagawa T, Sato K, Ogura H, Mori M, Wada T, Sakai Y, Yutani M, Matsumura T, Fujinaga Y, Gabata T, Wada T, Iwata Y. J Infect Chemother. 28 5 651-656 2022/01/22
- Effects of antibiotics on the viability of and toxin production by Clostridium botulinum. Yutani M, Matsumura T, Fujinaga Y. Microbiol Immunol. 65 10 432-437 2021/09/08
- Functional Analysis of Botulinum Hemagglutinin (HA). Matsumura T, Fujinaga Y*. Methods Mol. Biol. 2132 191-200 2020
- Botulinum Hemagglutinin: Critical Protein for Adhesion and Absorption of Neurotoxin Complex in Host Intestine. Amatsu S, Fujinaga Y* 2132 183-190 2020
- Fully Human Monoclonal Antibodies Effectively Neutralizing Botulinum Neurotoxin Serotype B Matsumura T, Amatsu S, Misaki R, Yutani M, Du A, Kohda T, Fujiyama K, Ikuta K, Fujinaga Y* Toxins 12 E302 2020
- Gut-derived Enterococcus faecium from ulcerative colitis patients promotes colitis in a genetically susceptible mouse host. Seishima J, Iida N, Kitamura K, Yutani M, Wang Z, Seki A, Yamashita T, Sakai Y, Honda M, Yamashita T, Kagaya T, Shirota Y, Fujinaga Y, Mizukoshi E, Kaneko S. Genome Biol. 20 1 252 2019/11/25
- Collagen adhesion gene is associated with bloodstream infections caused by methicillin-resistant Staphylococcus aureus. Iwata Y, Satou K, Furuichi K, Yoneda I, Matsumura T, Yutani M, Fujinaga Y, Hase A, Morita H, Ohta T, Senda Y, Sakai-Takemori Y, Wada T, Fujita S, Miyake T, Yasuda H, Sakai N, Kitajima S, Toyama T, Shinozaki Y, Sagara A, Miyagawa T, Hara A, Shimizu M, Kamikawa Y, Ikeo K, Shichino S, Ueha S, Nakajima T, Matsushima K, Kaneko S, Wada T. Int J Infect Dis 91 22 2020/02/01
- Maintenance of an undifferentiated state of human-induced pluripotent stem cells through botulinum hemagglutinin-mediated regulation of cell behavior. Shuzui E, Kim MH, Azuma K, Fujinaga Y, Kino-Oka M. J Biosci Bioeng 127 6 744 2019/06/01
- A Simple and Robust Method for Culturing Human-Induced Pluripotent Stem Cells in an Undifferentiated State Using Botulinum Hemagglutinin. Kim MH, Matsubara Y, Fujinaga Y, Kino-Oka M. Biotechnol J. 13 2 2018/02/01
- Translocation and dissemination of botulinum neurotoxin from the intestinal tract. Fujinaga Y, Popoff MR. Toxicon S0041-1010 17 30324-0 2017/10/01
- Multivalency effects of hemagglutinin component of type B botulinum neurotoxin complex on epithelial barrier disruption. Amatsu S, Matsumura T, Yutani M, Fujinaga Y. Microbiol Immunol. 62 2 80-89 2018/02/01
- Botulinum hemagglutinin-mediated selective removal of cells deviating from the undifferentiated state in hiPSC colonies. Kim MH, Sugawara Y, Fujinaga Y, Kino-oka M Scientific Reports 7 93 2017/03/01
Conference Presentations
- Endogenous production and neurotoxicity of novel botulinum neurotoxin (BoNT/X) in a clinical isolate(2023/03/16)
- Development of genetic manipulation methods for group I Clostridium botulinum. (conference：Interagency Botulinum Research Coordinating Committee)(2022/10/17)
- New insights into the pathobiology of Clostridium botulinum enteric infection (conference：The 15th Korea-Japan International Symposium on Microbiology)(2022/10/13)
- New insights into the pathobiology of Clostridium botulinum enteric infection(conference：The 20th Awaji International Forum on Infection and Immunity)(2022/09/07)
- Mechanisms of intestinal absorption of botulinum neurotoxin complex.(conference：Toxins 2017)(2017/01/19)
- Intestinal absorption mechanism of type B1 botulinum progenitor toxin produced by strain Okra.(conference：54th Interagency Botulism Research Coordinating Committee(IBRCC))(2017/10/22)
- E-cadherin機能阻害活性を維持した最小化ボツリヌス菌ヘマグルチニン由来物質の開発(conference：第６５回トキシンシンポジウム)(2018/07/11)
- Therapeutic and preventive effect of fully human monoclonal antibodies against type B botulinum intoxication.(conference：55th Interagency Botulism Research Coordinating Committee(IBRCC))(2018/10/24)
- Human-Derived monoclonal antibodies effectively neutralize botulinum neurotoxin.(conference：TOXINS 2019)(2019/01/16)
- Mechanism of pathogenesis of botulinum neurotoxin complex and its application. (conference：CLOSTPATH 11)(2019/08/19)
- Molecular engineering of Nano-HA, a minimal protein that inhibits E-cadherin-mediated cell-cell adhesion derived from Clostridium botulinum hemagglutinin.(conference：56th IBRCC 2019)(2019/10/27)
- New insights into the pathogenesis of Clostridium botulinum(2023/10/31)
- New insights on the pathophysiology of intestinal Clostridium botulinum infection : Learning from intestinal botulism. (conference：World Microbe Forum 2021)(2021/06/14)
- Clostridium botulinum enteric infections: Novel insights into the interplay between C. botulinum and gut microbiota (2022/02/04)
Others
Arts and Fieldwork
Patent
Theme to the desired joint research
Grant-in-Aid for Scientific Research
Competitive research funding,Contribution
Collaborative research,Consignment study
Classes (Bachelors)
○Medical Bacteriology(2019)
○Medical Bacteriology(2018)
○Medical Bacteriology(2017)
○Medical Bacteriology(2016)
Classes (Graduate Schools)
○Basic Training on Medical Researches(2019)
○Intensive Lectures on Medical Researches(2019)
○Bacterial Infections(2019)
○Medical Sciences(2019)
○Bacterial Infections(2019)
○The Human Body in Health and Disease Curriculum 1(2019)
○The Human Body in Health and Disease Curriculum 1(2019)
○Bacterial Infections(2018)
○Bacterial Infections(2018)
○Bacterial Infections(2018)
○Bacterial Infections(2017)
○Bacterial Infections(2017)
○Bacterial Infections(2017)
○Introduction to Basic Medical Science(2016)
○Bacterial Infections(2016)
○Bacterial Infections(2016)
○Bacterial Infections(2016)