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Researcher Information

last modified：2025/12/05

Assistant Professor　Fukuda, Koji

Faculty, Affiliation

Cancer Research Institute

College and School Educational Field


Laboratory

Academic Background

Career

Kanazawa university cancer institute(2017/11/01-)
South Illinois University school of medicine(2010/07/01-2012/07/31)

Year & Month of Birth

Academic Society





Award

Specialities

Speciality Keywords

Research Themes

Books

Papers

  • 　Enhanced Production of the Fluorinated Nucleoside Antibiotic Nucleocidin by a rifR-Resistant Mutant of Streptomyces calvus IFO13200　Koji Fukuda,Takashi Tamura,Yuko Segawa,Yuta Mutaguchi,Kenji Inagaki　Actinomycetologica　23　2　51　2009
  • 　Targeting WEE1 enhances the antitumor effect of KRAS-mutated non-small cell lung cancer harboring TP53 mutations.　Koji Fukuda,Shinji Takeuchi,Sachiko Arai,Shigeki Nanjo,Shigeki Sato,Hiroshi Kotani,Kenji Kita,Akihiro Nishiyama,Hiroyuki Sakaguchi,Koshiro Ohtsubo,Seiji Yano　Cell Reports Medicine　101578　2024/05/15
  • 　Bone morphogenetic protein 7 in dormancy and metastasis of prostate cancer stem-like cells in bone.　Aya Kobayashi,Hiroshi Okuda,Fei Xing,Puspa R Pandey,Misako Watabe,Shigeru Hirota,Sudha K Pai,Wen Liu,Koji Fukuda,Christopher Chambers,Andrew Wilber,Kounosuke Watabe　The Journal of experimental medicine　208　13　2641　2011/12/19
  • 　Resveratrol suppresses growth of cancer stem-like cells by inhibiting fatty acid synthase.　Puspa R Pandey,Hiroshi Okuda,Misako Watabe,Sudha K Pai,Wen Liu,Aya Kobayashi,Fei Xing,Koji Fukuda,Shigeru Hirota,Tamotsu Sugai,Go Wakabayashi,Keisuke Koeda,Masahiro Kashiwaba,Kazuyuki Suzuki,Toshimi Chiba,Masaki Endo,Tomoaki Fujioka,Susumu Tanji,Yin-Yuan Mo,Deliang Cao,Andrew C Wilber,Kounosuke Watabe　Breast cancer research and treatment　130　2　387　2011/11
  • 　KAI1 gene is engaged in NDRG1 gene-mediated metastasis suppression through the ATF3-NFkappaB complex in human prostate cancer.　Wen Liu,Megumi Iiizumi-Gairani,Hiroshi Okuda,Aya Kobayashi,Misako Watabe,Sudha K Pai,Puspa R Pandey,Fei Xing,Koji Fukuda,Vishnu Modur,Shigeru Hirota,Kazuyuki Suzuki,Toshimi Chiba,Masaki Endo,Tamotsu Sugai,Kounosuke Watabe　The Journal of biological chemistry　286　21　18949　2011/05/27

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  • 　Cacalol, a natural sesquiterpene, induces apoptosis in breast cancer cells by modulating Akt-SREBP-FAS signaling pathway.　Wen Liu,Eiji Furuta,Kazutoshi Shindo,Misako Watabe,Fei Xing,Puspa R Pandey,Hiroshi Okuda,Sudha K Pai,Laura L Murphy,Deliang Cao,Yin-Yuan Mo,Aya Kobayashi,Megumi Iiizumi,Koji Fukuda,Bo Xia,Kounosuke Watabe　Breast cancer research and treatment　128　1　57　2011/07
  • 　The role of tumor-associated macrophage in tumor progression.　Koji Fukuda,Aya Kobayashi,Kounosuke Watabe　Frontiers in bioscience (Scholar edition)　4　787　2012/01/01
  • 　Identification and Purification of an L-Alanine Dehydrogenase Homolog that Catalyzes the Formation of L-Ornithine Lactam from Sinefungin-Producing Streptomyces incarnatus NRRL8089　FUKUDA Koji,TAMURA Takashi,SATO Kumi,INAGAKI Kenji　Actinomycetologica　24　2　63　2010　
  • 　Production improvement of antifungal, antitrypanosomal nucleoside sinefungin by rpoB mutation and optimization of resting cell system of Streptomyces incarnatus NRRL 8089.　Koji Fukuda,Takashi Tamura,Hideyuki Ito,Sayaka Yamamoto,Kozo Ochi,Kenji Inagaki　Journal of bioscience and bioengineering　109　5　459　2010/05
  • 　Hypoxia-induced Jagged2 promotes breast cancer metastasis and self-renewal of cancer stem-like cells.　F Xing,H Okuda,M Watabe,A Kobayashi,S K Pai,W Liu,P R Pandey,K Fukuda,S Hirota,T Sugai,G Wakabayshi,K Koeda,M Kashiwaba,K Suzuki,T Chiba,M Endo,Y-Y Mo,K Watabe　Oncogene　30　39　4075　2011/09/29
  • 　Glycogen synthase kinase-3 inhibition overcomes epithelial-mesenchymal transition-associated resistance to osimertinib in EGFR-mutant lung cancer.　Koji Fukuda,Shinji Takeuchi,Sachiko Arai,Kenji Kita,Azusa Tanimoto,Akihiro Nishiyama,Seiji Yano　Cancer science　111　7　2374　2020/07
  • 　Draft Genome Sequence of Streptomyces incarnatus NRRL8089, which Produces the Nucleoside Antibiotic Sinefungin.　Kenshiro Oshima,Masahira Hattori,Hitomi Shimizu,Koji Fukuda,Michiko Nemoto,Kenji Inagaki,Takashi Tamura　Genome announcements　3　4　2015/07/09
  • 　Aberrant Methylation of Tumor Suppressive miRNAs in Bile from Patients With Pancreaticobiliary Diseases.　Koushiro Ohtsubo,Kunio Miyake,Sachiko Arai,Koji Fukuda,Naohiro Yanagimura,Chiaki Suzuki,Sakiko Otani,Yuta Adachi,Azusa Tanimoto,Akihiro Nishiyama,Kaname Yamashita,Shinji Takeuchi,Kenji Notohara,Kenichi Yoshimura,Seiji Yano　Anticancer research　39　10　5449　2019/10
  • 　Resminostat, a histone deacetylase inhibitor, circumvents tolerance to EGFR inhibitors in EGFR-mutated lung cancer cells with BIM deletion polymorphism.　Sachiko Arai,Shinji Takeuchi,Koji Fukuda,Azusa Tanimoto,Akihiro Nishiyama,Hiroaki Konishi,Akimitsu Takagi,Hiroyuki Takahashi,S Tiong Ong,Seiji Yano　The journal of medical investigation : JMI　67　3.4　343　2020
  • 　Notch3-dependent β-catenin signaling mediates EGFR TKI drug persistence in EGFR mutant NSCLC.　Rajeswara Rao Arasada,Konstantin Shilo,Tadaaki Yamada,Jianying Zhang,Seiji Yano,Rashelle Ghanem,Walter Wang,Shinji Takeuchi,Koji Fukuda,Nobuyuki Katakami,Keisuke Tomii,Fumitaka Ogushi,Yasuhiko Nishioka,Tiffany Talabere,Shrilekha Misra,Wenrui Duan,Paolo Fadda,Mohammad A Rahman,Patrick Nana-Sinkam,Jason Evans,Joseph Amann,Elena E Tchekneva,Mikhail M Dikov,David P Carbone　Nature communications　9　1　3198　2018/08/10
  • 　Reactive astrocytes promote the metastatic growth of breast cancer stem-like cells by activating Notch signalling in brain.　Fei Xing,Aya Kobayashi,Hiroshi Okuda,Misako Watabe,Sudha K Pai,Puspa R Pandey,Shigeru Hirota,Andrew Wilber,Yin-Yuan Mo,Brian E Moore,Wen Liu,Koji Fukuda,Megumi Iiizumi,Sambad Sharma,Yin Liu,Kerui Wu,Elizabeth Peralta,Kounosuke Watabe　EMBO molecular medicine　5　3　384　2013/03
  • 　Organ-specific efficacy of HSP90 inhibitor in multiple-organ metastasis model of chemorefractory small cell lung cancer.　Shinji Takeuchi,Koji Fukuda,Sachiko Arai,Shigeki Nanjo,Kenji Kita,Tadaaki Yamada,Eiji Hara,Hiroshi Nishihara,Hisanori Uehara,Seiji Yano　International journal of cancer　138　5　1281　2016/03/01
  • 　The human long non-coding RNA-RoR is a p53 repressor in response to DNA damage.　Ali Zhang,Nanjiang Zhou,Jianguo Huang,Qian Liu,Koji Fukuda,Ding Ma,Zhaohui Lu,Cunxue Bai,Kounosuke Watabe,Yin-Yuan Mo　Cell research　23　3　340　2013/03
  • 　Histone Deacetylase 3 Inhibition Overcomes BIM Deletion Polymorphism-Mediated Osimertinib Resistance in EGFR-Mutant Lung Cancer.　Azusa Tanimoto,Shinji Takeuchi,Sachiko Arai,Koji Fukuda,Tadaaki Yamada,Xavier Roca,S Tiong Ong,Seiji Yano　Clinical cancer research : an official journal of the American Association for Cancer Research　23　12　3139　2017/06/15
  • 　In vivo imaging xenograft models for the evaluation of anti-brain tumor efficacy of targeted drugs.　Kenji Kita,Sachiko Arai,Akihiro Nishiyama,Hirokazu Taniguchi,Koji Fukuda,Rong Wang,Tadaaki Yamada,Shinji Takeuchi,Shoichiro Tange,Atsushi Tajima,Mitsutoshi Nakada,Kazuo Yasumoto,Yoshiharu Motoo,Takashi Murakami,Seiji Yano　Cancer medicine　6　12　2972　2017/12
  • 　Foretinib Overcomes Entrectinib Resistance Associated with the NTRK1 G667C Mutation in NTRK1 Fusion-Positive Tumor Cells in a Brain Metastasis Model.　Akihiro Nishiyama,Tadaaki Yamada,Kenji Kita,Rong Wang,Sachiko Arai,Koji Fukuda,Azusa Tanimoto,Shinji Takeuchi,Shoichiro Tange,Atsushi Tajima,Noritaka Furuya,Takayoshi Kinoshita,Seiji Yano　Clinical cancer research : an official journal of the American Association for Cancer Research　24　10　2357　2018/05/15
  • 　Osimertinib Overcomes Alectinib Resistance Caused by Amphiregulin in a Leptomeningeal Carcinomatosis Model of ALK-Rearranged Lung Cancer.　Sachiko Arai,Shinji Takeuchi,Koji Fukuda,Hirokazu Taniguchi,Akihiro Nishiyama,Azusa Tanimoto,Miyako Satouchi,Kaname Yamashita,Koshiro Ohtsubo,Shigeki Nanjo,Toru Kumagai,Ryohei Katayama,Makoto Nishio,Mei-Mei Zheng,Yi-Long Wu,Hiroshi Nishihara,Takushi Yamamoto,Mitsutoshi Nakada,Seiji Yano　Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer　15　5　752　2020/05
  • 　Targeted therapy by MET inhibitors against small-cell lung cancer with aberrant activation of HGF/MET pathway　Hirokazu Taniguchi,Shinji Takeuchi,Koji Fukuda,Tadaaki Yamada,Shuichi Sakamoto,Manabu Kawada,Seiji Yano　CANCER RESEARCH　76　2016/07
  • 　Phase I study of vorinostat with gefitinib in BIM deletion polymorphism/epidermal growth factor receptor mutation double-positive lung cancer.　Shinji Takeuchi,Tetsunari Hase,Shinobu Shimizu,Masahiko Ando,Akito Hata,Haruyasu Murakami,Takahiro Kawakami,Katsuhiko Nagase,Kenichi Yoshimura,Tadami Fujiwara,Azusa Tanimoto,Akihiro Nishiyama,Sachiko Arai,Koji Fukuda,Nobuyuki Katakami,Toshiaki Takahashi,Yoshinori Hasegawa,Tun Kiat Ko,S Tiong Ong,Seiji Yano　Cancer science　111　2　561　2020/02
  • 　Podoplanin promotes progression of malignant pleural mesothelioma by regulating motility and focus formation　Shinji Takeuchi,Koji Fukuda,Tadaaki Yamada,Sachiko Arai,Satoshi Takagi,Genichiro Ishii,Atsushi Ochiai,Shotaro Iwakiri,Kazumi Itoi,Hisanori Uehara,Hiroshi Nishihara,Naoya Fujita,Seiji Yano　CANCER SCIENCE　108　4　696　2017/04
  • 　In vivo imaging models of bone and brain metastases and pleural carcinomatosis with a novel human EML4-ALK lung cancer cell line.　Shigeki Nanjo,Takayuki Nakagawa,Shinji Takeuchi,Kenji Kita,Koji Fukuda,Mitsutoshi Nakada,Hisanori Uehara,Hiroshi Nishihara,Eiji Hara,Hidetaka Uramoto,Fumihiro Tanaka,Seiji Yano　Cancer science　106　3　244　2015/03
  • 　Patient-derived xenograft models of non-small cell lung cancer for evaluating targeted drug sensitivity and resistance.　Kenji Kita,Koji Fukuda,Hiro Takahashi,Azusa Tanimoto,Akihiro Nishiyama,Sachiko Arai,Shinji Takeuchi,Kaname Yamashita,Koshiro Ohtsubo,Sakiko Otani,Naohiro Yanagimura,Chiaki Suzuki,Hiroko Ikeda,Masaya Tamura,Isao Matsumoto,Seiji Yano　Cancer science　110　10　3215　2019/10
  • 　Distribution and Activity of Lenvatinib in Brain Tumor Models of Human Anaplastic Thyroid Cancer Cells in Severe Combined Immune Deficient Mice.　Rong Wang,Tadaaki Yamada,Sachiko Arai,Koji Fukuda,Hirokazu Taniguchi,Azusa Tanimoto,Akihiro Nishiyama,Shinji Takeuchi,Kaname Yamashita,Koshiro Ohtsubo,Junji Matsui,Naoyoshi Onoda,Eishu Hirata,Shu Taira,Seiji Yano　Molecular cancer therapeutics　18　5　947　2019/05
  • 　Akt Kinase-Interacting Protein 1 Signals through CREB to Drive Diffuse Malignant Mesothelioma.　Tadaaki Yamada,Joseph M Amann,Koji Fukuda,Shinji Takeuchi,Naoya Fujita,Hisanori Uehara,Shotaro Iwakiri,Kazumi Itoi,Konstantin Shilo,Seiji Yano,David P Carbone　Cancer research　75　19　4188　2015/10/01
  • 　Roles of the cyclooxygenase 2 matrix metalloproteinase 1 pathway in brain metastasis of breast cancer.　Kerui Wu,Koji Fukuda,Fei Xing,Yingyu Zhang,Sambad Sharma,Yin Liu,Michael D Chan,Xiaobo Zhou,Shadi A Qasem,Radhika Pochampally,Yin-Yuan Mo,Kounosuke Watabe　The Journal of biological chemistry　290　15　9842　2015/04/10
  • 　Epithelial-to-Mesenchymal Transition Is a Mechanism of ALK Inhibitor Resistance in Lung Cancer Independent of ALK Mutation Status.　Koji Fukuda,Shinji Takeuchi,Sachiko Arai,Ryohei Katayama,Shigeki Nanjo,Azusa Tanimoto,Akihiro Nishiyama,Takayuki Nakagawa,Hirokazu Taniguchi,Takeshi Suzuki,Tadaaki Yamada,Hiroshi Nishihara,Hironori Ninomiya,Yuichi Ishikawa,Satoko Baba,Kengo Takeuchi,Atsushi Horiike,Noriko Yanagitani,Makoto Nishio,Seiji Yano　Cancer research　79　7　1658　2019/04/01
  • 　Impact of MET inhibition on small-cell lung cancer cells showing aberrant activation of the hepatocyte growth factor/MET pathway.　Hirokazu Taniguchi,Tadaaki Yamada,Shinji Takeuchi,Sachiko Arai,Koji Fukuda,Shuichi Sakamoto,Manabu Kawada,Hiroyuki Yamaguchi,Hiroshi Mukae,Seiji Yano　Cancer science　108　7　1378　2017/07
  • 　Amphiregulin triggered epidermal growth factor receptor activation confers in vivo crizotinib-resistance of EML4-ALK lung cancer and circumvention by epidermal growth factor receptor inhibitors.　Hirokazu Taniguchi,Shinji Takeuchi,Koji Fukuda,Takayuki Nakagawa,Sachiko Arai,Shigeki Nanjo,Tadaaki Yamada,Hiroyuki Yamaguchi,Hiroshi Mukae,Seiji Yano　Cancer science　108　1　53　2017/01
  • 　Anti-cancer drugs targeting fatty acid synthase (FAS).　Puspa R Pandey,Wen Liu,Fei Xing,Koji Fukuda,Kounosuke Watabe　Recent patents on anti-cancer drug discovery　7　2　185　2012/05/01
  • 　N-myc downstream regulated gene 1 modulates Wnt-β-catenin signalling and pleiotropically suppresses metastasis.　Wen Liu,Fei Xing,Megumi Iiizumi-Gairani,Hiroshi Okuda,Misako Watabe,Sudha K Pai,Puspa R Pandey,Shigeru Hirota,Aya Kobayashi,Yin-Yuan Mo,Koji Fukuda,Yi Li,Kounosuke Watabe　EMBO molecular medicine　4　2　93　2012/02
  • 　In vitro and in vivo anti-tumor activity of alectinib in tumor cells with NCOA4-RET.　Sachiko Arai,Kenji Kita,Azusa Tanimoto,Shinji Takeuchi,Koji Fukuda,Hiroshi Sato,Seiji Yano　Oncotarget　8　43　73766　2017/09/26
  • 　Hyaluronan synthase HAS2 promotes tumor progression in bone by stimulating the interaction of breast cancer stem-like cells with macrophages and stromal cells.　Hiroshi Okuda,Aya Kobayashi,Bo Xia,Misako Watabe,Sudha K Pai,Shigeru Hirota,Fei Xing,Wen Liu,Puspa R Pandey,Koji Fukuda,Vishnu Modur,Arnab Ghosh,Andrew Wilber,Kounosuke Watabe　Cancer research　72　2　537　2012/01/15
  • 　Inhibition of EGFR and MEK surmounts entrectinib resistance in a brain metastasis model of NTRK1-rearranged tumor cells.　Chiaki Suzuki,Akihiro Nishiyama,Sachiko Arai,Shoichiro Tange,Atsushi Tajima,Azusa Tanimoto,Koji Fukuda,Yohei Takumi,Hiroshi Kotani,Shinji Takeuchi,Naohiro Yanagimura,Koushiro Ohtsubo,Norio Yamamoto,Koichi Omori,Seiji Yano　Cancer science　113　7　2323　2022/07
  • 　Proteasome Inhibition Overcomes ALK-TKI Resistance in ALK-Rearranged/TP53-Mutant NSCLC via Noxa Expression.　Azusa Tanimoto,Shingo Matsumoto,Shinji Takeuchi,Sachiko Arai,Koji Fukuda,Akihiro Nishiyama,Kiyotaka Yoh,Takaya Ikeda,Naoki Furuya,Kazumi Nishino,Yuichiro Ohe,Koichi Goto,Seiji Yano　Clinical cancer research : an official journal of the American Association for Cancer Research　27　5　1410　2021/03/01
  • 　Transient IGF-1R inhibition combined with osimertinib eradicates AXL-low expressing EGFR mutated lung cancer.　Rong Wang,Tadaaki Yamada,Kenji Kita,Hirokazu Taniguchi,Sachiko Arai,Koji Fukuda,Minoru Terashima,Akihiko Ishimura,Akihiro Nishiyama,Azusa Tanimoto,Shinji Takeuchi,Koshiro Ohtsubo,Kaname Yamashita,Tomoyoshi Yamano,Akihiro Yoshimura,Koichi Takayama,Kyoichi Kaira,Yoshihiko Taniguchi,Shinji Atagi,Hisanori Uehara,Rikinari Hanayama,Isao Matsumoto,Xujun Han,Kunio Matsumoto,Wei Wang,Takeshi Suzuki,Seiji Yano　Nature communications　11　1　4607　2020/09/14
  • 　Comprehensive antitumor immune response boosted by dual inhibition of SUMOylation and MEK in MYC-expressing KRAS-mutant cancers.　Hiroshi Kotani,Tomoyoshi Yamano,Justin C Boucher,Shigeki Sato,Hiroyuki Sakaguchi,Koji Fukuda,Akihiro Nishiyama,Kaname Yamashita,Koushiro Ohtsubo,Shinji Takeuchi,Takumi Nishiuchi,Hiroko Oshima,Masanobu Oshima,Marco L Davila,Seiji Yano　Experimental hematology & oncology　13　1　94　2024/09/27
  • 　Dual inhibition of SUMOylation and MEK conquers MYC-expressing KRAS-mutant cancers by accumulating DNA damage.　Hiroshi Kotani,Hiroko Oshima,Justin C Boucher,Tomoyoshi Yamano,Hiroyuki Sakaguchi,Shigeki Sato,Koji Fukuda,Akihiro Nishiyama,Kaname Yamashita,Koushiro Ohtsubo,Shinji Takeuchi,Takumi Nishiuchi,Masanobu Oshima,Marco L Davila,Seiji Yano　Journal of biomedical science　31　1　68　2024/07/11
  • 　STAT3 inhibition suppresses adaptive survival of ALK-rearranged lung cancer cells through transcriptional modulation of apoptosis.　Naohiro Yanagimura,Shinji Takeuchi,Koji Fukuda,Sachiko Arai,Azusa Tanimoto,Akihiro Nishiyama,Naohisa Ogo,Hiroyuki Takahashi,Akira Asai,Satoshi Watanabe,Toshiaki Kikuchi,Seiji Yano　NPJ precision oncology　6　1　11　2022/02/28　
  • 　Multiple mutations in RNA polymerase β-subunit gene (rpoB) in Streptomyces incarnatus NRRL8089 enhance production of antiviral antibiotic sinefungin: modeling rif cluster region by density functional theory　Saori Ogawa,Hitomi Shimidzu,Koji Fukuda,Naoki Tsunekawa,Toshiyuki Hirano,Fumitoshi Sato,Kei Yura,Tomohisa Hasunuma,Kozo Ochi,Michio Yamamoto,Wataru Sakamoto,Kentaro Hashimoto,Hiroyuki Ogata,Tadayoshi Kanao,Michiko Nemoto,Kenji Inagaki,Takashi Tamura　Bioscience, Biotechnology, and Biochemistry　85　5　1275　2021/04/24　
  • 　MET kinase inhibitor reverses resistance to entrectinib induced by hepatocyte growth factor in tumors with NTRK1 or ROS1 rearrangements.　Yohei Takumi,Sachiko Arai,Chiaki Suzuki,Koji Fukuda,Akihiro Nishiyama,Shinji Takeuchi,Hiroki Sato,Kunio Matsumoto,Kenji Sugio,Seiji Yano　Cancer medicine　12　5　5809　2023/03
  • 　Targeting WEE1 to overcome ARID1A mutation-driven osimertinib resistance in EGFR-mutant lung cancer.　Koji Fukuda,Shigeki Nanjo,Shinji Takeuchi,Turja Chakrabarti,Tyiesha Brown,Sharon Wesley Dev Sahadevan,Sachiko Arai,Shigeki Sato,Hiroshi Kotani,Akihiro Nishiyama,Hiroyuki Sakaguchi,Koushiro Ohtsubo,Hiroaki Taniguchi,Collin M Blakely,Trever G Bivona,Seiji Yano　Journal of thoracic oncology　20　10　1459　2025/06/13
  • 　Trametinib overcomes KRAS-G12V-induced osimertinib resistance in a leptomeningeal carcinomatosis model of EGFR-mutant lung cancer.　Koji Fukuda,Sakiko Otani,Shinji Takeuchi,Sachiko Arai,Shigeki Nanjo,Azusa Tanimoto,Akihiro Nishiyama,Katsuhiko Naoki,Seiji Yano　Cancer science　112　9　3784　2021/09
  • 　Analysis of Methylation of Tumor-suppressive miRNAs and KRAS/TP53 Mutations in Pancreatic Juice.　Koushiro Ohtsubo,Kunio Miyake,Shigeki Sato,Hiroyuki Sakaguchi,Koji Fukuda,Hiroshi Kotani,Akihiro Nishiyama,Shigeki Nanjo,Kaname Yamashita,Shinji Takeuchi,Seiji Yano,Sawako Kuruma,Jun Nakahodo,Masataka Kikuyama,Hiroaki Taniguchi　Anticancer research　44　12　5253　2024/12
  • 　Methylation of Tumor Suppressive miRNAs in Plasma from Patients With Pancreaticobiliary Diseases.　Koushiro Ohtsubo,Kunio Miyake,Sachiko Arai,Koji Fukuda,Chiaki Suzuki,Hiroshi Kotani,Azusa Tanimoto,Akihiro Nishiyama,Shigeki Nanjo,Kaname Yamashita,Shinji Takeuchi,Seiji Yano　Cancer diagnosis & prognosis　2　3　378　2022
  • 　GSK-3 inhibition overcomes EMT-associated resistance to osimertinib in EGFR mutant lung cancer　Koji Fukuda, Shinji Takeuchi, Sachiko Arai, Kenji Kita, Azusa Tanimoto, Akihiro Nishiyama, Seiji Yano　Cancer Science　111　7　2374-2384　2020
  • 　Osimertinib Overcomes Alectinib Resistance Caused by Amphiregulin in a Leptomeningeal Carcinomatosis Model of ALK-Rearranged Lung Cancer　Arai S, Takeuchi S, Fukuda K, Taniguchi H, Nishiyama A, Tanimoto A, Satouchi M, Yamashita K, Ohtsubo K, Nanjo S, Kumagai T, Katayama R, Nishio M, Zheng MM, Wu YL, Nishihara H, Yamamoto T, Nakada M, Yano S.　J Thorac Oncl　2020/01/21
  • 　Phase I study of vorinostat with gefitinib in BIM deletion polymorphism/epidermal growth factor receptor mutation double-positive lung cancer　Takeuchi S, Hase T, Shimizu S, Ando M, Hata A, Murakami H, Kawakami T, Nagase K, Yoshimura K, Fujiwara T, Tanimoto A, Nishiyama A, Arai S, Fukuda K, Katakami N, Takahashi T, Hasegawa Y, Ko TK, Ong ST, Yano S.　Cancer Science　111　2　561-570　2020/02/01
  • 　Distribution and Activity of Lenvatinib in Brain Tumor Models of Human Anaplastic Thyroid Cancer Cells in Severe Combined Immune Deficient Mice.　Wang R, Yamada T, Arai S, Fukuda K, Taniguchi H, Tanimoto A, Nishiyama A, Takeuchi S, Yamashita K, Ohtsubo K, Matsui J, Onoda N, Hirata E, Taira S, Yano S.　Mol Cancer Ther　18　5　947-956　2019/05/01
  • 　Aberrant Methylation of Tumor Suppressive miRNAs in Bile from Patients With Pancreaticobiliary Diseases.　Ohtsubo K, Miyake K, Arai S, Fukuda K, Yanagimura N, Suzuki C, Otani S, Adachi Y, Tanimoto A, Nishiyama A, Yamashita K, Takeuchi S, Notohara K, Yoshimura K, Yano S　Anticancer Res　39　10　5449-59　2019/10/01
  • 　Patient-derived xenograft models of non-small cell lung cancer for evaluating targeted drug sensitivity and resistance.　Kita K, Fukuda K, Takahashi H, Tanimoto A, Nishiyama A, Arai S, Takeuchi S, Yamashita K, Ohtsubo K, Otani S, Yanagimura N, Suzuki C, Ikeda H, Tamura M, Matsumoto I, Yano S.　Cancer Science　110　10　3215-3224　2019/10/01
  • 　Epithelial-to-mesenchymal transition is a mechanism of ALK inhibitor resistance in lung cancer independent of ALK mutation status.　Fukuda K, Takeuchi S, Arai S, Katayama R, Nanjo S, Tanimoto A, Nishiyama A, Nakagawa T, Taniguchi H, Suzuki T, Yamada T, Nishihara H, Ninomiya H, Ishikawa Y, Baba S, Takeuchi K, Horiike A, Yanagitani N, Nishio M, Yano S.　Cancer Research　2019/02/08
  • 　Notch3-dependent β-catenin signaling mediates EGFR TKI drug persistence in EGFR mutant NSCLC.　Arasada RR, Shilo K, Yamada T, Zhang J, Yano S, Ghanem R, Wang W, Takeuchi S, Fukuda K, Katakami N, Tomii K, Ogushi F, Nishioka Y, Talabere T, Misra S, Duan W, Fadda P, Rahman MA, Nana-Sinkam P, Evans J, Amann J, Tchekneva EE, Dikov MM, Carbone DP.　Nature Communications　2018/08/10
  • 　Foretinib Overcomes Entrectinib Resistance Associated with the NTRK1 G667C Mutation in NTRK1 Fusion-Positive Tumor Cells in a Brain Metastasis Model.　Clinical Cancer Research　2018/02/20
  • 　In vivo imaging xenograft models for the evaluation of anti-brain tumor efficacy of targeted drugs.　Kita K, Arai S, Nishiyama A, Taniguchi H, Fukuda K, Wang R, Yamada T, Takeuchi S, Tange S, Tajima A, Nakada M, Yasumoto K, Motoo Y, Murakami T, Yano S　Cancer Medicine　2017/11/01
  • 　In vitro and in vivo anti-tumor activity of alectinib in tumor cells with NCOA4-RET　Sachiko Arai , Kenji Kita , Azusa Tanimoto , Shinji Takeuchi , Koji Fukuda , Hiroshi Sato, Seiji Yano　Oncotarget　in publish　2017/03/19
  • 　Podoplanin promotes progression of malignant pleural mesothelioma by regulating motility and focus formation.　Takeuchi S, Fukuda K, Yamada T, Arai S, Takagi S, Ishii GI, Ochiai A, Iwakiri S, Itoi K, Uehara H, Nishihara H, Fujita N, Yano S.　Cancer Science　 [Epub ahead of print]　2017/02/09
  • 　Histone Deacetylase 3 Inhibition Overcomes BIM Deletion Polymorphism-Mediated Osimertinib Resistance in EGFR-Mutant Lung Cancer.　Tanimoto A, Takeuchi S, Arai S, Fukuda K, Yamada T, Roca X, Ong ST, Yano S　Clinical cancer research　2016/12/16
  • 　Organ-specific efficacy of HSP90 inhibitor in multiple-organ metastasis model of chemorefractory small cell lung cancer.　Takeuchi S, Fukuda K, Arai S, Nanjo S, Kita K, Yamada T, Hara E, Nishihara H, Uehara H, Yano S.　International Journal of cancer　138　5　1281-9　2016
  • 　Amphiregulin triggered epidermal growth factor receptor activation confers in vivo crizotinib-resistance of EML4-ALK lung cancer and circumvention by epidermal growth factor receptor inhibitors.　Taniguchi H, Takeuchi S, Fukuda K, Nakagawa T, Arai S, Nanjo S, Yamada T, Yamaguchi H, Mukae H, Yano S.　Cancer Science　108　1　53-60　2017/01/01

Conference Presentations

  • Epithelial-mesenchymal transition as an idependent mechanism of ALK inhibitor resistance in EML4-ALK lung cancer(conference：The 77th Annual Meeting of the Japanese Cancer Association)(2018/09/27)
  • Epithelial-to-mesenchymal transition is a mechanism of ALK inhibitor resistance in lung cancer independent of ALK mutation status.(conference：IASLC 2019 World Conference on Lung Cancer.)(2019/09)
  • Epithelial-To-Mesenchymal Transition Is a Mechanisms of ALK inhibitor Resistance in Lung Cancer Independent of ALK Mutation Status (conference：IASLC 2019 World Conference on Lung Cancer)(2019/09/07)
  • Epithelial-mesenchymal transition is a mechanism of ALK inhibitor resistance in lung cancer independent of ALK mutation status (2019/06/12)
  • Heterogeneity of epithelial-to-mesenchymal transition and resistance mutation in ALK inhibitor-resistant lung cancer and its circumvention.(conference：Fifth AACR-IASLC International Joint Conference)(2018/01/08)

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  • HDAC inhibition overcomes crizotinib-resistance by mesenchymal-epithelial transition (MET) in EML4-ALK lung cancer cells (2016/10/06)
  • HDAC inhibition overcomes crizotinib-resistance by inducing mesenchymal-epithelial reverting transition (MERT) via miR-200c up-regulation in EML4-ALK lung cancer cells.(conference：Tenth AACR-JCA joint conference)(2016)

Others

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「KRAS変異肺癌におけるDNA損傷応答経路を標的とした新規治療法の開発」(2024-2026)　
○「EGFR肺癌の髄膜癌腫症におけるEGFR-TKI耐性克服治療の開発」(2021-2023)　
○「miR-200sを標的とした肺癌のEMTに起因するTKI耐性克服治療の開発」(2018-2020)　
○「ALK肺癌のEMTに起因するALK-TKI耐性克服治療の開発」(2016-)　

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

Classes (Graduate Schools)

International Project

International Students

Lecture themes

Others (Social Activities)

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