Associate Professor MISHIRO, Kenji
Faculty, Affiliation
Institute for Frontier Science Initiative Research Unit on Molecular Probe Development
Associate Professor
College and School Educational Field
Laboratory
Research Unit on Molecular Probe Development
Academic Background
【Academic background(Doctoral/Master's Degree)】
Kyoto University Doctor Graduate School of Pharmaceutical Science Pharmaceutical Science Completed
Kyoto University Master Graduate School of Pharmaceutical Science Pharmaceutical Science Completed
【Academic background(Bachelor's Degree)】
Kyoto University Total Pharmaceutical Science
【Degree】
PhD
Career
Kanazawa University Institute for Frontier Science Initiative Assistant Professor (tenure track)(2016/01/15-)
Columbia University Department of Chemistry Postdoctoral Research Fellow(2013/08/01-2016/01/10)
Kyoto University Institute for Chemical Research Technical Assistant(2013/04/01-2013/07/31)
Edinburgh University School of Chemistry Visiting Researcher(2012/01/02-2012/03/22)
Year & Month of Birth
Academic Society
The Society of Synthetic Organic Chemistry
The Pharmaceutical Society of Japan
Award
Specialities
Organic chemistry、Chemical pharmacy
Speciality Keywords
Research Themes
Development of photochemical reactions useful for molecular probe development.
Development of molecular probes useful for diagnosis and therapeutics.
Development of novel bioactive compounds
Books
Papers
- Phototriggered Dehydration Condensation using an Aminocyclopropenone K. Mishiro*, Y. Yushima, M, Kunishima* Org. Lett. 19 18 4912-4915 2017
- Phototriggered Ketone Formation from an Aminocyclopropenone and a Carboxylic Acid K. Mishiro*, Y. Yushima, M, Kunishima* J. Org. Chem. 83 21 13595-13603 2018
- Phototriggered Active Alkyne Generation from Cyclopropenones with Visible Light-Responsive Photocatalysts K. Mishiro*, T. Kimura, T. Furuyama, and M. Kunishima* Org. Lett. 2019
- Efficiency Enhancement of a Photocatalytic Decarbonylation of an Aminocyclopropenone by Benzothiophene Substitution K. Mishiro*, M. Nomura, T. Furuyama, M. Kunishima* J. Org. Chem. 2021
- Synthesis and evaluation of a deltic guanidinium analogue of a cyclic RGD peptide Kenji Mishiro,Takahiro Ueno,Hiroshi Wakabayashi,Masato Fukui,Seigo Kinuya,Kazuma Ogawa Organic & Biomolecular Chemistry 21 9 1937 2023/02
- Epitope-Based Specific Antibody Modifications. Saki Horie,Kenji Mishiro,Mio Nishino,Inori Domae,Mitsuo Wakasugi,Tsukasa Matsunaga,Munetaka Kunishima Bioconjugate chemistry 34 11 2022 2023/11/15
- Phototriggered Generation of Ynol Ethers and Their Rearrangement to Ketenes. Shunsuke Mogami,Masanobu Baba,Taniyuki Furuyama,Munetaka Kunishima,Kenji Mishiro The Journal of organic chemistry 2024/07/16
- Phototriggered Butenolide Formation from a Cyclobutenedione and an Acidic Nucleophile. Kenji Mishiro,Aiko Sesumi,Takanori Fujii,Taniyuki Furuyama,Munetaka Kunishima Organic letters 26 1 380 2024/01/12
- Radiotheranostics with radiolanthanides: Design, development strategies, and medical applications Kenji Mishiro, Hirofumi Hanaoka, Aiko Yamaguchi, Kazuma Ogawa* Coord. Chem. Rev. 383 104-131 2019
- Development of Radiohalogenated Osimertinib Derivatives as Imaging Probes for Companion Diagnostics of Osimertinib. Kenji Mishiro,Ryuichi Nishii,Izumi Sawazaki,Tomoki Sofuku,Takeshi Fuchigami,Hitomi Sudo,Nurmaya Effendi,Akira Makino,Yasushi Kiyono,Kazuhiro Shiba,Junichi Taki,Seigo Kinuya,Kazuma Ogawa Journal of medicinal chemistry 65 3 1835 2022/02/10
- RGD Peptide-Conjugated Dodecaborate with the Ga-DOTA Complex: A Preliminary Study for the Development of Theranostic Agents for Boron Neutron Capture Therapy and Its Companion Diagnostics. Kenji Mishiro,Sayaka Imai,Yuki Ematsu,Katsumi Hirose,Takeshi Fuchigami,Masayuki Munekane,Seigo Kinuya,Kazuma Ogawa Journal of medicinal chemistry 65 24 16741 2022/12/13
- Synthesis and evaluation of a rociletinib analog as prospective imaging double mutation L858R/T790M in non-small cell lung cancer,Síntesis y evaluación de un análogo de rociletinib como imagen prospectiva de la doble mutación L858R/T790M en cáncer de pulmón no microcítico Fawwaz, M.,Mishiro, K.,Purwono, B.,Nishii, R.,Ogawa, K. Journal of Pharmacy and Pharmacognosy Research 12 2 2024
- Synthesis and initial in vitro evaluation of olmutinib derivatives as prospective imaging probe for non-small cell lung cancer. Muammar Fawwaz,Kenji Mishiro,Arwansyah Arwansyah,Ryuichi Nishii,Kazuma Ogawa BioImpacts : BI 14 1 27774 2024
- Development of probes for radiotheranostics with albumin binding moiety to increase the therapeutic effects of astatine-211 (211At). Hiroaki Echigo,Kenji Mishiro,Masayuki Munekane,Takeshi Fuchigami,Kohshin Washiyama,Kazuhiro Takahashi,Yoji Kitamura,Hiroshi Wakabayashi,Seigo Kinuya,Kazuma Ogawa European journal of nuclear medicine and molecular imaging 51 2 412 2023/10/11
Conference Presentations
Others
Arts and Fieldwork
Patent
Theme to the desired joint research
○Chemical modification of biomolecules using photochemical reactions
○Bioactivity assay of novel chemicals
Grant-in-Aid for Scientific Research
○「Development of phototriggered reactions using strained molecules」(2018-2019)
○「光励起によるin situ活性種生成を利用した新規反応及び生体分子標識法の開発」(2016-2017)
Competitive research funding,Contribution
Collaborative research,Consignment study
Classes (Bachelors)
○Basic Medical and Pharmaceutical Sciences Rotation Practice（Course in Pharmaceutical Sciences）Ⅲ(2023)
○Basic Medicinal Chemistry(2023)
○Analytical Chemistry(2023)
○Physical Organic Chemistry(2023)
○Experiments in Organic Chemistry(2023)
○Early Research in Pharmacy(2023)
○Seminar in Organic Chemistry 1(2023)
○Presentation and Debate(2023)
○Organic Chemistry 1B(2023)
○Analytical Chemistry 2(2023)
○Organic Chemistry 1A(2023)
○Bioorganic Chemistry(2023)
○Seminar in Organic Chemistry 1(2023)
○Organic Chemistry 1(2023)
Classes (Graduate Schools)
○Laboratory Rotation I(2023)
○Introduction to Discovering Molecular Probes b(2023)
○Advanced Course of Pharmachemistry(2023)
○Introduction to Pharmachemistry(2023)
○Organic Photochemistry in Life Science(2022)