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Researcher Information

last modified:2020/04/10

Assistant Professor MISHIRO, Kenji

Faculty, Affiliation

 Research Unit on Molecular Probe Development
Assistant Professor (tenure track)

College and School Educational Field


Laboratory

Research Unit on Molecular Probe Development

Academic Background

【Academic background(Doctoral/Master's Degree)】
Kyoto University Doctor Graduate School of Pharmaceutical Science Pharmaceutical Science Completed
Kyoto University Master Graduate School of Pharmaceutical Science Pharmaceutical Science Completed
【Academic background(Bachelor's Degree)】
Kyoto University Total Pharmaceutical Science
【Degree】
PhD

Career

Kanazawa University Institute for Frontier Science Initiative Assistant Professor (tenure track)(2016/01/15-)
Columbia University Department of Chemistry Postdoctoral Research Fellow(2013/08/01-2016/01/10)
Kyoto University Institute for Chemical Research Technical Assistant(2013/04/01-2013/07/31)
Edinburgh University School of Chemistry Visiting Researcher(2012/01/02-2012/03/22)

Year & Month of Birth

Academic Society

American Chemical Society
The Society of Synthetic Organic Chemistry
The Pharmaceutical Society of Japan

Award

Specialities

Organic chemistry、Chemical pharmacy

Speciality Keywords

Research Themes

Development of photochemical reactions useful for molecular probe development.

Development of molecular probes useful for diagnosis and therapeutics.

Development of novel bioactive compounds

Books

Papers

  •  Phototriggered Active Alkyne Generation from Cyclopropenones with Visible Light-Responsive Photocatalysts K. Mishiro*, T. Kimura, T. Furuyama, and M. Kunishima* Org. Lett. 2019 
  •  Phototriggered Ketone Formation from an Aminocyclopropenone and a Carboxylic Acid K. Mishiro*, Y. Yushima, M, Kunishima* J. Org. Chem. 83 21 13595-13603 2018 
  •  Phototriggered Dehydration Condensation using an Aminocyclopropenone K. Mishiro*, Y. Yushima, M, Kunishima* Org. Lett. 19 18 4912-4915 2017 
  •  Radiotheranostics Coupled between an At-211-Labeled RGD Peptide and the Corresponding Radioiodine-Labeled RGD Peptide K. Ogawa*, T. Takeda, K. Mishiro, A. Toyoshima, K. Shiba, T. Yoshimura, A. Shinohara, S. Kinuya, A. Odani  ACS Omega 4 3 4584-4591 2019
  •  Syntheses and evaluation of a homologous series of aza-vesamicol as improved radioiodine-labeled probes for sigma-1 receptor imaging K. Ogawa*, R. Masuda, K. Mishiro, M. Wang, T. Kozaka, K. Shiba, S. Kinuya, A. Odani  Bioorg. Med. Chem 27 10 1990-1996 2019

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  •  Design, synthesis, and biological evaluation of radioiodinated benzo[d]imidazole-quinoline derivatives for platelet-derived growth factor receptor β (PDGFRβ) imaging. Effendi N, Mishiro K, Takarada T, Yamada D, Nishii R, Shiba K, Kinuya S, Odani A, Ogawa K*  Bioorg. Med. Chem 2019
  •  Fundamental study of radiogallium-labeled aspartic acid peptides introducing octreotate derivatives. Ishizaki A, Mishiro K, Shiba K, Hanaoka H, Kinuya S, Odani A, Ogawa K* Annals of nuclear medicine 2019
  •  Radiobrominated benzimidazole-quinoline derivatives as Platelet-derived growth factor receptor beta (PDGFRβ) imaging probes Nurmaya Effendi, Kenji Mishiro, Takeshi Takarada, Akira Makino, Daisuke Yamada, Yoji Kitamura, Kazuhiro Shiba, Yasushi Kiyono, Akira Odani & Kazuma Ogawa* Sci. Rep. 8 10369 2018
  •  Substrate selectivity of human aldehyde oxidase 1 in reduction of nitroaromatic drugs T. Ogiso, T. Fukami*, K. Mishiro, K. Konishi, J. P. Jones, M. Nakajima Archives of Biochemistry and Biophysics  659 1 85-92 2018
  •  Synthesis and evaluation of radioiodinated 1-{2-[5-(2-methoxyethoxy)-1H-benzo [d] imidazol-1-yl] quinolin-8-yl} piperidin-4-amine derivatives for platelet-derived growth factor receptor β (PDGFRβ) imaging N. Effendi, K. Ogawa*, K. Mishiro, T. Takarada, D. Yamada, Y. Kitamura, K. Shiba, T. Maeda and A. Odani  Bioorg. Med. Chem 2017
  •  Radiotheranostics with radiolanthanides: Design, development strategies, and medical applications Kenji Mishiro, Hirofumi Hanaoka, Aiko Yamaguchi, Kazuma Ogawa* Coord. Chem. Rev. 383 104-131 2019

Conference Presentations

Arts and Fieldwork

Patent

Theme to the desired joint research

○Chemical modification of biomolecules using photochemical reactions
○Bioactivity assay of novel chemicals

Grant-in-Aid for Scientific Research

○「Development of phototriggered reactions using strained molecules」(2018-2019) 
○「光励起によるin situ活性種生成を利用した新規反応及び生体分子標識法の開発」(2016-2017) 

Classes (Bachelors)

○Experiments in Organic Chemistry(2017)

Classes (Graduate Schools)

International Project

International Students

Lecture themes

Others (Social Activities)

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