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Researcher Information

last modified:2021/09/28

Associate Professor TSUGE, Yota

Laboratory Website

Faculty, Affiliation

Institute for Frontier Science Initiative

College and School Educational Field

Division of Natural Sciences, Graduate School of Natural Science and Technology

Laboratory

Academic Background

【Academic background(Doctoral/Master's Degree)】
Nara Institute for Science and Technology Graduate School of Biological Sciences Completed
【Academic background(Bachelor's Degree)】
Kyoto University

Career

Yale University Department of Molecular, Cellular and Developmental Biology Postdoctoral Fellow
Research Institute of Innovative Technology for the Earth Researcher
Kobe University Organization of Advanced Science and Technology Research Assistant Professor
Kanazawa University Institute for Frontier Science Initiative Assistant Professor

Year & Month of Birth

Academic Society

Award

Specialities

Applied microbiology、Metabolic engineering、Biological engineering、Molecular and cellular biology

Speciality Keywords

Research Themes

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Books

  •  Tsuge Y, Kondo A Production of Platform Chemicals from Sustainable Resources  Springer Singapore 2017

Papers

  •  Recent progress in production of amino acid-derived chemicals using Corynebacterium glutamicum. Yota Tsuge,Hiroki Matsuzawa World journal of microbiology & biotechnology 37 3 49 2021/02/11 
  •  Elevated, non-proliferative temperatures change the profile of fermentation products in Corynebacterium glutamicum. Hikaru Mizuno,Yota Tsuge Applied microbiology and biotechnology 105 1 367 2021/01 
  •  Enhanced methane production from cellulose using a two-stage process involving a bioelectrochemical system and a fixed film reactor. Kengo Sasaki,Daisuke Sasaki,Yota Tsuge,Masahiko Morita,Akihiko Kondo Biotechnology for biofuels 14 1 7 2021/01/06 
  •  Optimal Ratio of Carbon Flux between Glycolysis and the Pentose Phosphate Pathway for Amino Acid Accumulation in Corynebacterium glutamicum. Katsuki Murai,Daisuke Sasaki,Shunsuke Kobayashi,Akira Yamaguchi,Hiroto Uchikura,Tomokazu Shirai,Kengo Sasaki,Akihiko Kondo,Yota Tsuge ACS synthetic biology 9 7 1615 2020/07/17
  •  Requirement of de novo synthesis of pyruvate carboxylase in long-term succinic acid production in Corynebacterium glutamicum. Hiroto Uchikura,Kazuaki Ninomiya,Kenji Takahashi,Yota Tsuge Applied microbiology and biotechnology 104 10 4313 2020/05

show all

  •  Automatic Redirection of Carbon Flux between Glycolysis and Pentose Phosphate Pathway Using an Oxygen-Responsive Metabolic Switch in Corynebacterium glutamicum. Shunsuke Kobayashi,Hideo Kawaguchi,Tomokazu Shirai,Kazuaki Ninomiya,Kenji Takahashi,Akihiko Kondo,Yota Tsuge ACS synthetic biology 9 4 814 2020/04/17
  •  Metabolic engineering of Corynebacterium glutamicum for hyperproduction of polymer-grade L- and D-lactic acid. Yota Tsuge,Naoto Kato,Shogo Yamamoto,Masako Suda,Toru Jojima,Masayuki Inui Applied microbiology and biotechnology 103 8 3381 2019/04
  •  Changes in the microbial consortium during dark hydrogen fermentation in a bioelectrochemical system increases methane production during a two-stage process. Kengo Sasaki,Daisuke Sasaki,Yota Tsuge,Masahiko Morita,Akihiko Kondo Biotechnology for biofuels 11 173 2018
  •  Sucrose purification and repeated ethanol production from sugars remaining in sweet sorghum juice subjected to a membrane separation process. Kengo Sasaki,Yota Tsuge,Hideo Kawaguchi,Masahiro Yasukawa,Daisuke Sasaki,Takashi Sazuka,Eiji Kamio,Chiaki Ogino,Hideto Matsuyama,Akihiko Kondo Applied microbiology and biotechnology 101 15 6007 2017/08
  •  FudC, a protein primarily responsible for furfural detoxification in Corynebacterium glutamicum. Yota Tsuge,Motonori Kudou,Hideo Kawaguchi,Jun Ishii,Tomohisa Hasunuma,Akihiko Kondo Applied microbiology and biotechnology 100 6 2685 2016/03
  •  Less biomass and intracellular glutamate in anodic biofilms lead to efficient electricity generation by microbial fuel cells. Daisuke Sasaki,Kengo Sasaki,Yota Tsuge,Akihiko Kondo Biotechnology for biofuels 12 72 2019
  •  3-Amino-4-hydroxybenzoic acid production from sweet sorghum juice by recombinant Corynebacterium glutamicum. Hideo Kawaguchi,Kengo Sasaki,Kouji Uematsu,Yota Tsuge,Hiroshi Teramura,Naoko Okai,Sachiko Nakamura-Tsuruta,Yohei Katsuyama,Yoshinori Sugai,Yasuo Ohnishi,Ko Hirano,Takashi Sazuka,Chiaki Ogino,Akihiko Kondo Bioresource technology 198 410 2015/12
  •  Toward the complete utilization of rice straw: Methane fermentation and lignin recovery by a combinational process involving mechanical milling, supporting material and nanofiltration. Kengo Sasaki,Mami Okamoto,Tomokazu Shirai,Yota Tsuge,Ayami Fujino,Daisuke Sasaki,Masahiko Morita,Fumio Matsuda,Jun Kikuchi,Akihiko Kondo Bioresource technology 216 830 2016/09
  •  Mechanical milling and membrane separation for increased ethanol production during simultaneous saccharification and co-fermentation of rice straw by xylose-fermenting Saccharomyces cerevisiae. Kengo Sasaki,Yota Tsuge,Daisuke Sasaki,Hiroshi Teramura,Kentaro Inokuma,Tomohisa Hasunuma,Chiaki Ogino,Akihiko Kondo Bioresource technology 185 263 2015/06
  •  Glucose consumption rate critically depends on redox state in Corynebacterium glutamicum under oxygen deprivation. Yota Tsuge,Kimio Uematsu,Shogo Yamamoto,Masako Suda,Hideaki Yukawa,Masayuki Inui Applied microbiology and biotechnology 99 13 5573 2015/07
  •  Metabolic engineering of Corynebacterium glutamicum for production of sunscreen shinorine. Yota Tsuge,Hideo Kawaguchi,Shogo Yamamoto,Yoshiko Nishigami,Masahiro Sota,Chiaki Ogino,Akihiko Kondo Bioscience, biotechnology, and biochemistry 82 7 1252 2018/07
  •  Engineering cell factories for producing building block chemicals for bio-polymer synthesis. Yota Tsuge,Hideo Kawaguchi,Kengo Sasaki,Akihiko Kondo Microbial cell factories 15 19 2016/01/21
  •  Comparative metabolic state of microflora on the surface of the anode electrode in a microbial fuel cell operated at different pH conditions. Daisuke Sasaki,Kengo Sasaki,Yota Tsuge,Akihiko Kondo AMB Express 6 1 125 2016/12
  •  Enhanced production of d-lactate from mixed sugars in Corynebacterium glutamicum by overexpression of glycolytic genes encoding phosphofructokinase and triosephosphate isomerase. Yota Tsuge,Naoto Kato,Shogo Yamamoto,Masako Suda,Masayuki Inui Journal of bioscience and bioengineering 127 3 288 2019/03
  •  Anaerobic glucose consumption is accelerated at non-proliferating elevated temperatures through upregulation of a glucose transporter gene in Corynebacterium glutamicum. Hiroto Uchikura,Koichi Toyoda,Hiroki Matsuzawa,Hikaru Mizuno,Kazuaki Ninomiya,Kenji Takahashi,Masayuki Inui,Yota Tsuge Applied microbiology and biotechnology 104 15 6719 2020/08
  •  Overexpression of the phosphofructokinase encoding gene is crucial for achieving high production of D-lactate in Corynebacterium glutamicum under oxygen deprivation. Yota Tsuge,Shogo Yamamoto,Naoto Kato,Masako Suda,Alain A Vertès,Hideaki Yukawa,Masayuki Inui Applied microbiology and biotechnology 99 11 4679 2015/06
  •  1,5-Diaminopentane production from xylooligosaccharides using metabolically engineered Corynebacterium glutamicum displaying beta-xylosidase on the cell surface. Kenta Imao,Rie Konishi,Mayumi Kishida,Yuuki Hirata,Shota Segawa,Noriko Adachi,Rena Matsuura,Yota Tsuge,Takuya Matsumoto,Tsutomu Tanaka,Akihiko Kondo Bioresource technology 245 Pt B 1684 2017/12
  •  Two-step production of D-lactate from mixed sugars by growing and resting cells of metabolically engineered Lactobacillus plantarum. Yota Tsuge,Hideo Kawaguchi,Kengo Sasaki,Tsutomu Tanaka,Akihiko Kondo Applied microbiology and biotechnology 98 11 4911 2014/06
  •  Optimized membrane process to increase hemicellulosic ethanol production from pretreated rice straw by recombinant xylose-fermenting Saccharomyces cerevisiae. Kengo Sasaki,Yota Tsuge,Daisuke Sasaki,Tomohisa Hasunuma,Takatoshi Sakamoto,Yuri Sakihama,Chiaki Ogino,Akihiko Kondo Bioresource technology 169 380 2014/10
  •  Increased ethanol production from sweet sorghum juice concentrated by a membrane separation process. Kengo Sasaki,Yota Tsuge,Daisuke Sasaki,Hiroshi Teramura,Satoshi Wakai,Hideo Kawaguchi,Takashi Sazuka,Chiaki Ogino,Akihiko Kondo Bioresource technology 169 821 2014/10
  •  High-throughput transposon mutagenesis of Corynebacterium glutamicum and construction of a single-gene disruptant mutant library. Nobuaki Suzuki,Naoko Okai,Hiroshi Nonaka,Yota Tsuge,Masayuki Inui,Hideaki Yukawa Applied and environmental microbiology 72 5 3750 2006/05
  •  Phenyllactic acid production by simultaneous saccharification and fermentation of pretreated sorghum bagasse. Hideo Kawaguchi,Hiroshi Teramura,Kouji Uematsu,Kiyotaka Y Hara,Tomohisa Hasunuma,Ko Hirano,Takashi Sazuka,Hidemi Kitano,Yota Tsuge,Prihardi Kahar,Satoko Niimi-Nakamura,Ken-Ichi Oinuma,Naoki Takaya,Shigemitsu Kasuga,Chiaki Ogino,Akihiko Kondo Bioresource technology 182 169 2015/04
  •  Detoxification of furfural in Corynebacterium glutamicum under aerobic and anaerobic conditions. Yota Tsuge,Yoshimi Hori,Motonori Kudou,Jun Ishii,Tomohisa Hasunuma,Akihiko Kondo Applied microbiology and biotechnology 98 20 8675 2014/10
  •  Simultaneous saccharification and fermentation of kraft pulp by recombinant Escherichia coli for phenyllactic acid production Hideo Kawaguchi,Kouji Uematsu,Chiaki Ogino,Hiroshi Teramura,Satoko Niimi-Nakamura,Yota Tsuge,Tomohisa Hasunuma,Ken-Ichi Oinuma,Naoki Takaya,Akihiko Kondo BIOCHEMICAL ENGINEERING JOURNAL 88 188 2014/07
  •  Multiple large segment deletion method for Corynebacterium glutamicum. Nobuaki Suzuki,Hiroshi Nonaka,Yota Tsuge,Satoshi Okayama,Masayuki Inui,Hideaki Yukawa Applied microbiology and biotechnology 69 2 151 2005/11
  •  Deletion of cgR_1596 and cgR_2070, encoding NlpC/P60 proteins, causes a defect in cell separation in Corynebacterium glutamicum R. Yota Tsuge,Hidetaka Ogino,Haruhiko Teramoto,Masayuki Inui,Hideaki Yukawa Journal of bacteriology 190 24 8204 2008/12
  •  Random segment deletion based on IS31831 and Cre/loxP excision system in Corynebacterium glutamicum. Yota Tsuge,Nobuaki Suzuki,Masayuki Inui,Hideaki Yukawa Applied microbiology and biotechnology 74 6 1333 2007/04
  •  Comparative analysis of the Corynebacterium glutamicum group and complete genome sequence of strain R. Hideaki Yukawa,Crispinus A Omumasaba,Hiroshi Nonaka,Péter Kós,Naoko Okai,Nobuaki Suzuki,Masako Suda,Yota Tsuge,Junko Watanabe,Yoko Ikeda,Alain A Vertès,Masayuki Inui Microbiology (Reading, England) 153 Pt 4 1042 2007/04
  •  Increase in lactate yield by growing Corynebacterium glutamicum in a bioelectrochemical reactor. Kengo Sasaki,Yota Tsuge,Daisuke Sasaki,Akihiko Kondo Journal of bioscience and bioengineering 117 5 598 2014/05
  •  Utilization of lactic acid bacterial genes in Synechocystis sp. PCC 6803 in the production of lactic acid. Ancy Joseph,Shimpei Aikawa,Kengo Sasaki,Yota Tsuge,Fumio Matsuda,Tsutomu Tanaka,Akihiko Kondo Bioscience, biotechnology, and biochemistry 77 5 966 2013
  •  Direct production of organic acids from starch by cell surface-engineered Corynebacterium glutamicum in anaerobic conditions. Yota Tsuge,Toshihiro Tateno,Kengo Sasaki,Tomohisa Hasunuma,Tsutomu Tanaka,Akihiko Kondo AMB Express 3 1 72 2013/12/17
  •  Comparison of metabolomic profiles of microbial communities between stable and deteriorated methanogenic processes. Daisuke Sasaki,Kengo Sasaki,Yota Tsuge,Masahiko Morita,Akihiko Kondo Bioresource technology 172 83 2014/11
  •  New multiple-deletion method for the Corynebacterium glutamicum genome, using a mutant lox sequence. Nobuaki Suzuki,Hiroshi Nonaka,Yota Tsuge,Masayuki Inui,Hideaki Yukawa Applied and environmental microbiology 71 12 8472 2005/12
  •  Precipitate obtained following membrane separation of hydrothermally pretreated rice straw liquid revealed by 2D NMR to have high lignin content. Kengo Sasaki,Mami Okamoto,Tomokazu Shirai,Yota Tsuge,Hiroshi Teramura,Daisuke Sasaki,Hideo Kawaguchi,Tomohisa Hasunuma,Chiaki Ogino,Fumio Matsuda,Jun Kikuchi,Akihiko Kondo Biotechnology for biofuels 8 88 2015
  •  Recent advances in the metabolic engineering of Corynebacterium glutamicum for the production of lactate and succinate from renewable resources. Yota Tsuge,Tomohisa Hasunuma,Akihiko Kondo Journal of industrial microbiology & biotechnology 42 3 375 2015/03
  •  Repeated ethanol production from sweet sorghum juice concentrated by membrane separation. Kengo Sasaki,Yota Tsuge,Daisuke Sasaki,Hideo Kawaguchi,Takashi Sazuka,Chiaki Ogino,Akihiko Kondo Bioresource technology 186 351 2015/06
  •  Isolation of a new insertion sequence, IS13655, and its application to Corynebacterium glutamicum genome mutagenesis. Yota Tsuge,Nobuaki Suzuki,Kana Ninomiya,Masayuki Inui,Hideaki Yukawa Bioscience, biotechnology, and biochemistry 71 7 1683 2007/07
  •  Reactions upstream of glycerate-1,3-bisphosphate drive Corynebacterium glutamicum (D)-lactate productivity under oxygen deprivation. Yota Tsuge,Shougo Yamamoto,Masako Suda,Masayuki Inui,Hideaki Yukawa Applied microbiology and biotechnology 97 15 6693 2013/08
  •  Cre/loxP-mediated deletion system for large genome rearrangements in Corynebacterium glutamicum. Nobuaki Suzuki,Yota Tsuge,Masayuki Inui,Hideaki Yukawa Applied microbiology and biotechnology 67 2 225 2005/04
  •  A new insertion sequence, IS14999, from Corynebacterium glutamicum. Yota Tsuge,Kana Ninomiya,Nobuaki Suzuki,Masayuki Inui,Hideaki Yukawa Microbiology (Reading, England) 151 Pt 2 501 2005/02
  •  Large-scale engineering of the Corynebacterium glutamicum genome. Nobuaki Suzuki,Satoshi Okayama,Hiroshi Nonaka,Yota Tsuge,Masayuki Inui,Hideaki Yukawa Applied and environmental microbiology 71 6 3369 2005/06
  •  Isolation and characterization of a native composite transposon, Tn14751, carrying 17.4 kilobases of Corynebacterium glutamicum chromosomal DNA. Masayuki Inui,Yota Tsuge,Nobuaki Suzuki,Alain A Vertès,Hideaki Yukawa Applied and environmental microbiology 71 1 407 2005/01

Conference Presentations

Others

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

○Introduction of Biochemical Engineering 1(2017)
○Experiments in Biochemical Engineering B(2017)
○Introduction of Biochemical Engineering 2(2017)
○Experiments in Biochemical Engineering A(2017)

Classes (Graduate Schools)

International Project

International Students

Lecture themes

Others (Social Activities)

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