last modified：2024/03/19
Assistant Professor HARA, Satoshi
Faculty, Affiliation
University Hospital Nephrology and Rheumatology
Research Associate
College and School Educational Field
Laboratory
Academic Background
Career
Year & Month of Birth
1982/12
Academic Society
Award
Specialities
Kidney internal medicine、Collagenous pathology/Allergology
Speciality Keywords
Renal Pathology, Podocyte, IgG4-related disease, Collagen disease
Research Themes
Books
- Satoshi Hara, Yasunori Suzuki, Mitsuhiro Kawano Diagnosis and Thearpy of Sjoegren syndrome, 3rd edition 2018/09/20
- Zoshima T, Kawano M, Hara S, Nagata M IgG4-Related Kidney Disease Springer 2016
- Kawano M, Hara S, Ubara Y. IgG4-Related Kidney Disease Springer 2016
- Yamaguchi Y, Hara S, Kawano M. IgG4-Related Kidney Disease Springer 2016
- Hara S, Kawano M, Mizushima I, Harada K, Takata T, Saeki T, Ubara Y, Sato Y, Nagata M. IgG4-Related Kidney Disease Springer 2016
- Nagata M, Hara S IgG4-Related Kidney Disease Springer 2016
Papers
- Podocyte injury-driven lipid peroxidation accelerates the infiltration of glomerular foam cells in focal segmental glomerulosclerosis. Hara S, Kobayashi N, Sakamoto K, Ueno T, Manabe S, Takashima Y, Hamada J, Pastan I, Fukamizu A, Matsusaka T, Nagata M. Am J Pathol 185 2118-31 2015
- Distribution and components of interstitial inflammation and fibrosis in IgG4-related kidney disease: analysis of autopsy specimens. Hara S, Kawano M, Mizushima I, Harada K, Takata T, Saeki T, Ubara Y, Sato Y, Nagata M. Human Pathol 55 164-73 2016
- Diffuse glomerular nodular lesions in diabetic pigs carrying a dominant-negative mutant hepatocyte nuclear factor 1-alpha, an inheritant diabetic gene in humans. Hara S, Umeyama K, Yokoo T, Nagashima H, Nagata M. PLoS One 9 e92219 2014
- A condition closely mimicking IgG4-related disease despite the absence of serum IgG4 elevation and IgG4-positive plasma cell infiltration. Hara S, Kawano M, Mizushima I, Yamada K, Fujita K, Harada K, Matsumura M, Yamagishi M, Sato Y, Yamaguchi Y, Nagata M. Mod Rheumatol 26 784-9 2016
- Images in clinical medicine. Crowned dens syndrome. Matsumura M, Hara S. N Engl J Med 367 e34 2012
- Heparan sulfate 6-O-endosulfatases, Sulf1 and Sulf2, regulate glomerular integrity by modulating growth factor signaling. 12. Takashima Y, Keino-Masu K, Yashiro H, Hara S, Suzuki T, van Kuppevelt TH, Masu M, Nagata M. Am J Physiol Renal Physiol. 310 F395-408 2016
- Podocyte injury-driven intracapillary plasminogen activator inhibitor type 1 accelerates podocyte loss via uPAR-mediated β1-integrin endocytosis. 10. Kobayashi N, Ueno T, Ohashi K, Yamashita H, Takahashi Y, Sakamoto K, Manabe S, Hara S, Takashima Y, Dan T, Pastan I, Miyata T, Kurihara H, Matsusaka T, Reiser J, Nagata M. Am J Physiol Renal Physiol. 308 F614-26 2015
- The direction and role of phenotypic transition between podocytes and parietal epithelial cells in focal segmental glomerulosclerosis. Sakamoto K, Ueno T, Kobayashi N, Hara S, Takashima Y, Pastan I, Matsusaka T, Nagata M. Am J Physiol Renal Physiol. 306 F98-104 2014
- Light-microscopic characteristics of IgG4-related tubulointerstitial nephritis: distinction from non-IgG4-related tubulointerstitial nephritis. Yoshita K, Kawano M, Mizushima I, Hara S, Ito Y, Imai N, Ueno M, Nishi S, Nomura H, Narita I, Saeki T. Nephrol Dial Transplant 27 2755-2761 2012
- Multicentric Castleman Disease With Tubulointerstitial Nephritis Mimicking IgG4-related Disease: Two Case Reports. Zoshima T, Yamada K, Hara S, Mizushima I, Yamagishi M, Harada K, Sato Y, Kawano M. Am J Surg Pathol 40 495-501 2016
- Analysis of IgG4-positive clones in affected organs of IgG4-related disease. Kakuchi Y, Yamada K, Ito K, Hara S, Fujii H, Yamagishi M, Kawano M. Mod Rheumatol 26 923-8 2016
- cryoglobulinemic vasculitis Satoshi Hara 92 2 443-448 2022
- IgG4-related disease Satoshi Hara, Mitsuhiro Kawano 91 1 153-159 2021
- Interdisciplinary groups perform better than intradisciplinary groups in online group discussion activities. Yamashita T, Osawa S, Ota K, Minami T, Morisaki Y, Takahashi Y, Itatani T, Hara S, Tamai T, Fujiu M, Nomura H, Okamoto R. Med Edu Online 26 1886649 2021
- Association of proteinuria with incident atrial fibrillation in the general Japanese population. Tanaka Y, Tada H, Hara S, Hayashi K, Patel RB, Nishikawa T, Hashiba A, Takamura M, Greenland P, Kawashiri MA J Caridol 77 100-105 2021
- Fulminant myocarditis and pulmonary cavity lesion induced by disseminated mucormycosis in a chronic hemodialysis patient: Report of an autopsied case. Fujisawa Y, Hara S, Zoshima T, Maekawa N, Inoue D, Sasaki M, Gamou T, Nagata Y, Hayashi K, Takeji A, Ito K, Mizushima I, Fujii H, Kawano M Pathol Int 70 557-562 2020
- Glomerulonephritis with severe nephrotic syndrome induced by immune complexes composed of galactose-deficient IgA1 in primary Sjӧgren’s syndrome: a case report. Nishioka R, Hara S, Kawahara H, Ito K, Mizushima I, Hirata M, Nagata M, Kawano M. BMC Nephrol 25 108 2021
- Significance of kidney biopsy in autosomal dominant tubulointerstitial kidney disease-UMOD: is kidney biopsy truly nonspecific? Onoe T, Hara S, Yamada K, Zoshima T, Mizushima I, Ito K, Mori T, Daimon S, Muramoto H, Shimizu M, Iguchi A, Kuma A, Ubara Y, Mitobe M, Tsuruta H, Kishimoto N, Imura J, Konoshita T, Kawano M. BMC Nephrol 22 1 2021
- ANCA-associated nephritis without crescent formation has atypical clinicopathological features: a multicenter retrospective study. Zoshima T, Suzuki K, Suzuki F, Hara S, Mizuguchi K, Ito K, Mizushima I, Fujii H, Nomura H, Kawano M. Clin Exp Nephrol 244 999-1006 2020
- Tertiary lymphoid tissue in early-stage IgG4-related tubulointerstitial nephritis incidentally detected with a tumor lesion of the ureteropelvic junction: a case report. Miyanaga T, Mizuguchi K, Hara S, Zoshima T, Inoue D, Nishioka R, Mizushima I, Ito K, Fujii H, Yamada K, Sato Y, Yanagita M, Kawano M. BMC Nephrol 22 34 2021
- HHV-8-negative multicentric Castleman disease patients with serological, histopathological and imaging features of IgG4-related disease. Kawano M, Hara S, Yachie A, Inoue D, Sato Y, Fajgenbaum DC. Rheumatology(Oxford) 60 e3-e4 2021
- Hypocomplementemia Is Related to Elevated Serum Levels of IgG Subclasses Other Than IgG4 in IgG4-Related Kidney Disease. Fujisawa Y, Mizushima I, Yamada K, Yamamoto M, Saeki T, Matsui S, Tsuge S, Hara S, Kiyoaki I, Fujii H, Takahashi H, Nomura H, Kawa S, Kawano M Mod Rheumatol. 31 241-248 2021
- A Long-term Survival After Surgical Treatment for Atypical Aortic Coarctation Comlicating Takayasu Arteritis With Inactive Disease at the Diagnosis: An Appropriately Treated Autopsy Case. Yoshida M, Zoshima T, Hara S, Mizushima I, Fujii H, Yamada K, Sato Y, Harada K, Kawano M. Intern Med 58 2241-2246 2019
- A Case Report of Crystalline Light Chain Inclusion-Associated Kidney Disease Affecting Podocytes but Without Fanconi Syndrome: A Clonal Analysis of Pathological Monoclonal Light Chain. Ito K*, Hara S*, Yamada K, Zoshima T, Mizushima I, Fujii H, Miyazaki R, Kawai Y, Yachie A, Nagata M, Izui S, Yamagichi M, Kawano M. Medicine (Baltimore) 98 e13915 2019
- Possible Role of Complement Factor H in Podocytes in Clearing Glomerular Subendothelial Immune Complex Deposits. Zoshima T, Hara S, Yamagishi M, Pastan I, Matsusaka T, Kawano M, Nagata M. Sci Rep 9 7857 2019
- Different Factors Underlie Recurrent and De Novo Organ Involvement in Immunoglobulin G4-related Disease Mizushima I, Tsuge S, Fujisawa Y, Hara S, Suzuki F, Ito K, Fujii H, Yamada K, Kawano M. Rheumatology (Oxford) 59 513-8 2020
- A case of IgG4-related kidney disease with predominantly unilateral renal atrophy Takeji A, Yamada K, Inoue D, Mizushima I, Hara S, Ito K, Fujii H, Nakajima K, Mizutomi K, Yamagishi M, Kawano M CEN Case Rep 8 8-13 2019
- A case of IgG4-related tubulointerstitial nephritis and membranous glomerulonephritis during the clinical course of gastric cancer: Imaging features of IgG4-related kidney disease. Horita M, Fujii H, Mizushima I, Fujisawa Y, Hara S, Yamada K, Inoue D, Nakajima K, Harada K, Kawano M. Mod Rheumatol. 29 542-546 2019
- New clues to the nature of immunoglobulin G4-related disease: a retrospective Japanese multicenter study of baseline clinical features of 334 cases Yamada K, Yamamoto M, Saeki T, Mizushima I, Matsui S, Fujisawa Y, Hara S, Takahashi H, Nomura H, Kawa S, Kawano M Arthritis Res Ther 19 262 2017
- Focal segmental glomerulosclerosis; why does it occur segmentally? Nagata M, Kobayashi M, Hara S Pflugers Arch 469 983-988 2017
- Post-infectious acute glomerulonephritis with podocytopathy induced by parvovirus B19 infection Hara S, Hirata M, Ito K, Mizushima I, Fujii H, Yamada K, Nagata M, Kawano M Pathol Int 68 190-195 2018
- A case developing minimal change disease during the course of IgG4-related disease Yamada K, Zoshima T, Ito K, Mizushima I, Hara S, Horita S, Nuka H, Hamano R, Fujii H, Yamagishi M, Kawano M Mod Rheumatol 27 4 712-715 2017
- Validation of an automated sample preparation module directly connected to LC-MS/MS (CLAM-LC-MS/MS system) and comparison with conventional immunoassays for quantitation of tacrolimus and cyclosporin A in a clinical setting. Shimada T, Kawakami D, Fujita A, Yamamoto R, Hara S, Ito K, Mizushima I, Kitajima S, Iwata Y, Sakai N, Kawano M, Wada T, Sai Y. J Pharm Health Care Sci 2024/01/08
- Pediatric IgG4-related disease: a descriptive review. Hara S, Yoshida M, Sanada H, Suzuki Y, Sato Y, Mizushima I, Kawano M. Exp Rev Clin Rheumatol 20 97 2024
- De novo normotensive scleroderma renal crisis six years after living-donor renal transplantation in a patient with overlapping systemic sclerosis/systemic lupus erythematosus syndrome: a case report. Sanada H, Hara S, Horita M, Kawahara M, Yoshida M, Takahashi Y, Tsuge S, Zoshima T, Nishioka R, Ito K, Mizushima I, Matsuhita T, Kawano M. 2023/12/04
- Clues to mortality trends and their related factors in IgG4-related disease: A Japanese single-centre retrospective study. Kawahara H, Mizushima I, Tsuge S, Shin S, Yoshinobu T, Hoshiba R, Nishioka R, Zoshima T, Hara S, Ito K, Kawano M. Mod Rheumatol. 33 1154 2023
- Development of Remitting Seronegative Symmetrical Synovitis with Pitting Edema Syndrome with Pembrolizumab for Lung Squamous Cell Carcinoma: A Case Report. Yoshida M, Hara S, Nishioka R, Kobayashi T, Murase Y, Kimura H, Mizushima I, Kawano M. Intern Med. 2023/12/11
- Impact of gut microbiome on serum IgG4 levels in the general population: Shika-machi super preventive health examination results. Koshida A, Karashima S, Ogura K, Miyajima Y, Ogai K, Mizoguchi R, Ikegawa Y, Hara S, Mizushima I, Fujii H, Kawano M, Tsujiguchi H, Hara A, Nakamura H, Okamoto S. Front Cell Infect Microbiol. 2023/10/16
- Long-term outcomes of lupus nephritis with low-level proteinuria: a multicenter, retrospective study. Zoshima T, Hara S, Suzuki K, Yoshida M, Konishi M, Hibino S, Suda T, Hoshiba R, Kawahara H, Horita S, Nuka H, Mizushima I, Kawano M. Rheumatology (Oxford) 2023/11/24
- Feasibility and reliability of the pandemic-adapted online-onsite hybrid graduation OSCE in Japan. Hara S, Ohta K, Aono D, Tamai T, Kurachi M, Sugimori K, Mihara H, Ichimura H, Yamamoto Y, Nomura H. Adv Health Sci Edu Theory Pract 2023/10/18
- Case report: Rosai-Dorfman disease with rare extranodal lesions in the pelvis, heart, liver and skin. Yoshida M, Zoshima T, Hara S, Takahashi Y, Nishioka R, Ito K, Mizuhima I, Inoue D, Nakada S, Kawano M. Front Oncol. 12 1083500 2023
- Evaluating tubulointerstitial compartments in renal biopsy specimens using a deep learning-based approach for classifying normal and abnormal tubules. Hara S, Haneda E, Kawakami M, Morita K, Nishioka R, Zoshima T, Kometani M, Yoneda T, Kawano M, Karashima S, Nambo H. PLoS One 17 7 e0271161 2022
- Development of IgG4-related pancreatitis and kidney disease 7 years after the onset of undiagnosed lymphadenopathy: A case report. Yoshida M, Mizushima I, Tsuge S, Takahashi Y, Zoshima T, Nishioka R, Hara S, Ito K, Kawano M. Mod Rheumatol Case Rep. 7 1 192-196 2023
- Central fibrous area in the glomerular vascular pole consists of fibrous collagens and is associated with advanced age: a cross-sectional study. Hara S, Yamaguchi Y, Zoshima T, Mizushima I, Yamada K, Inoue R, Muto H, Mizutomi K, Hirata M, Araki H, Miyazaki R, Kawano M. BMC Nephrol 23 204 2022
- Impact of salt intake on urinary albumin excretion in patients with type 2 diabetic nephropathy: a retrospective cohort study based on a generalized additive model. Kotake Y, Karashima S, Kawakami M, Hara S, Aono D, Konishi S, Kometani M, Mori H, Takeda Y, Yoneda T, Nambo H, Furukawa K. Endocr J 69 5 577-583 2022
- Urinary abnormality in mixed connective tissue disease predicts development of other connective tissue diseases and decrease in renal function. Nishioka R, Zoshima T, Hara S, Suzuki Y, Ito K, Yamada K, Nakashima A, Tani Y, Kawane T, Hirata M, Mizushima I, Kawano M. Mod Rheumatol 32 1 155-62 2022
- Factors contributing to discrepant estimated glomerular filtration values measured by creatinine and cystatin C in patients with rheumatoid arthritis. Nakashima A, Horita S, Matsunaga T, Inoue R, Zoshima T, Mizushima I, Hara S, Ito K, Fujii H, Nomura H, Kawano M. Sci Rep 11 9884 2021
- Pneumonia and central nervous system infection caused by reactivation of varicella-zoster virus in a living-donor kidney transplantation patient: a case report and review of the literature. Takahashi Y, Hara S, Hoshiba R, Hibino S, Ito K, Zoshima T, Suzuki Y, Inoue D, Mizushima I, Fujii H, Kawano M. CEN Case Rep 10 370-377 2021
- Antiphospholipid antibody syndrome-associated renal thrombotic microangiopathy improved not with rivaroxaban but with warfarin in a systemic lupus erythematosus patient without lupus nephritis. Horita S, Zoshima T, Hara S, Koichi M, Hirayama S, Suzuki K, Nakashima A, Kawano M. CEN Case Rep 10 409-413 2021
- Serum IgG4 levels at diagnosis can predict unfavorable outcomes of untreated patients with IgG4-related disease. Mizushima I, Konishi M, Sanada H, Suzuki K, Takeji A, Zoshima T, Hara S, Ito K, Fujii H, Yamada K, Kawano M. Sci Rep 11 13341 2021
- Positive disease-specific autoantibodies have limited clinical significance in diagnosing IgG4-related disease in daily clinical practice. 12. Mizushima I, Yamano T, Kawahara H, Hibino S, Nishioka R, Zoshima T, Hara S, Ito K, Fujii H, Nomura H, Kawano M. Rheumatology (Oxford) 60 3317-25 2021
Conference Presentations
- Secondary FSGS due to chronic dehydration by excessive dieting: a case report(conference： ISN Frontier Meeting)(2018/02/25)
- Clinical impact of peritubular capillaritis on renal prognosis in ANCA-associated glomerulonephritis(conference：ASN Kidney Week 2017)(2017/11/03)
- Benign clinical course and histological change of living-related change of living-related renal transplant from the donor with membranous nephropathy.(conference： BANFF-SCT Joint Scientific Meeting)(2017/03/21)
Others
- cryoglobulinemic vasculitis Satoshi Hara 92 2 443-448 2022
- IgG4-related disease Satoshi Hara, Mitsuhiro Kawano 91 1 153-159 2021
Arts and Fieldwork
Patent
Theme to the desired joint research
Grant-in-Aid for Scientific Research
○「M蛋白血症に起因する軽鎖結晶蓄積性組織球症による腎障害の病態解析と治療開発」(2016-2018)
○「IgG4関連疾患における自然免疫の役割と新規治療ターゲットの探索」(2017-2019)
○「医師養成課程における臨床実習後客観的臨床能力試験の信頼性向上に関する研究」(2018-2020)
○「Integrinを標的とした糸球体硬化進展の新規機序解明と特異的治療の開発」(2019-2022)
○「糸球体内皮細胞におけるGalectin-8を標的とした糸球体硬化進展の新規機序解明」(2023-2025)
○「モデルマウスを用いたIgG4関連疾患における喫煙の影響の解明と疾病予防的指針の確立」(2023-2026)
○「補体経路に着目したIgG4関連腎臓病の病態解析と特異的治療開発」(2023-2027)
○「免疫グロブリン軽鎖による腎障害の病態解明」(2021-2023)
Competitive research funding,Contribution
Collaborative research,Consignment study
Classes (Bachelors)
○Medical Examination and Clinical Reasoning(2023)
○Immunology & Allergic Disorders(2023)
○Early Clinical Exposure(2023)
○Early Clinical Exposure(2023)
○Medical Examination and Clinical Reasoning(2022)
○Immunology & Allergic Disorders(2022)
○Introduction to Medical Science(2022)
○Early Clinical Exposure(2022)
○Career Dsign and Plan(2018)