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Researcher Information

last modified：2024/09/06

Assistant Professor　ISHIKAWA, Tatsuya

Faculty, Affiliation

Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences

College and School Educational Field


Laboratory

Department of Functional Anatomy

Academic Background

Career

Year & Month of Birth

Academic Society

Award

Specialities

General anatomy (including histology/embryology)、Pain science

Speciality Keywords

Research Themes

Books

Papers

  • 　Phase-specific plasticity of synaptic structures in the somatosensory cortex of living mice during neuropathic pain.　Kim Sk, Kato G, Ishikawa T, Nabekura J　Mol Pain　2011
  • 　in vivo imaging of enteric neurogenesis in the deep tissue of mouse small intestine　Goto, K, Kato G, Kawahara I, Luo Y, Obata K, Misawa H, Ishikawa T, Kuniyasu H, Nabekura J, Takaki M　PLoS One.　2013
  • 　Early-life stress increases the motility of microglia in adulthood.　Takatsuru Y, Nabekura J, Ishikawa T, Kohsaka S, Koibuchi N.　J Physiol Sci.　2015
  • 　Cortical astrocytes rewire somatosensory cortical circuits for peripheral neuropathic pain.　Kim SK, Hayashi H, Ishikawa T, Shibata K, Shigetomi E, Shinozaki Y, Inada H, Roh SE, Kim SJ, Lee G, Bae H, Moorhouse AJ, Mikoshiba K, Fukazawa Y, Koizumi S, Nabekura J　J Clin Invest.　2016
  • 　Microglial Contact Prevents Excess Depolarization and Rescues Neurons from Excitotoxicity.　Kato G, Inada H, Wake H, Akiyoshi R, Miyamoto A, Eto K, Ishikawa T, Moorhouse AJ, Strassman AM, Nabekura J　eNeuro　2016

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  • 　Cortical astrocytes prime the induction of spine plasticity and mirror image pain　Ishikawa T, Eto K, Kim SK, Wake H, Takeda I, Horiuchi H, Moorhouse AJ, Ishibashi H, Nabekura J　Pain　159　8　1592-1606　2018
  • 　Microglial SIRPα regulates the emergence of CD11c+ microglia and demyelination damage in white matter.　1. Sato-Hashimoto M, Nozu T, Toriba R, Horikoshi A, Akaike M, Kawamoto K, Hirose A, Hayashi Y, Nagai H, Shimizu W, Saiki A, Ishikawa T, Elhanbly R, Kotani T, Murata Y, Saito Y, Naruse M, Shibasaki K, Oldenborg PA, Jung S, Matozaki T, Fukazawa Y, Ohnishi H.　Elife　2019
  • 　Region‐ and neuronal‐subtype‐specific expression of Na,K‐ATPase alpha and beta subunit isoforms in the mouse brain.　1. Murata K, Kinoshita T, Ishikawa T, Kuroda K, Hoshi M, Fukazawa Y.　The Journal of Comparative Neurology　528　16　2654-2678　2020
  • 　Antihypersensitivity effect of betanin (red beetroot extract) via modulation of microglial activation in a mouse model of neuropathic pain.　5. Kwankaew N, Okuda H, Aye-Mon A, Ishikawa T, Hori K, Sonthi P, Kozakai Y, Ozaki N.　European Journal of Pain　2021
  • 　Differences in cellular and microstructural properties of the semitendinosus muscle tendon between young and adult patients.　1. Asai K, Nakase J, Ishikawa T, Yoshimizu R, Kimura M, Ozaki N, Tsuchiya H.　Journal of Orthopaedic Science　21　51　58　2021
  • 　Hedgehog signaling plays a crucial role in hyperalgesia associated with neuropathic pain in mice.　Okuda H, Ishikawa T, Hori K, Kwankaew N, Ozaki N.　J Neurochem.　2022
  • 　Transient astrocytic mGluR5 expression drives synaptic plasticity and subsequent chronic pain in mice 　6. Danjo Y, Shigetomi E, Hirayama JY, Kobayashi K, Ishikawa T, Fukazawa Y, Shibata K, Takanashi K, Parajuli B, Shinozaki Y, Kim SK, Nabekura J and Koizumi S.　J. Exp. Med.　2022
  • 　Multiple factors contribute to flight behaviors during fear conditioning.　3. Furuyama T, Imayoshi A, Iyobe T, Ono M, Ishikawa T, Ozaki N, Kato N, Yamamoto R.　Sci Rep.　27　13(1)　10402　2023
  • 　Pain related neuronal ensembles in the primary somatosensory cortex contribute to hyperalgesia and anxiety　Ishikawa T, Murata K, Okuda H, Potapenko I, Hori K, Furuyama T, Yamamoto R, Ono M, Kato N, Fukazawa Y, Ozaki N.　iScience　2023
  • 　Growth-related changes in the ultrastructure of the quadriceps tendon.　4. Kimura M, Nakase J, Ishikawa T, Asai K, Yoshimizu R, Kanayama T, Yanatori Y, Ozaki N, Tsuchiya H.　Knee　5　42　357-363　2023
  • 　Differences in the microstructural and mechanical qualities of semitendinosus tendon grafts between skeletally immature and mature patients in anterior cruciate ligament reconstruction.　Asai K, Nakase J, Kuzumaki T, Ishikawa T, Ozaki N, Tsuchiya H.　J Orthop Sci.　2023
  • 　Cilostazol improves the prognosis after hepatectomy in rats with sinusoidal obstruction syndrome.　1. Sugita H, Nakanuma S, Munesue S, Ishikawa T, Tokoro T, Takei R, Okazaki M, Kato K, Takada S, Makino I, Ozaki N, Yamamoto Y, Yagi S.　J Gastroenterol Hepatol.　2024
  • 　Combined Experiments with in Vivo Fiber Photometry and Behavior Tests Can Facilitate the Measurement of Neuronal Activity in the Primary Somatosensory Cortex and Hyperalgesia in an Inflammatory Pain Mice Model.　Ishikawa T, Uta D, Okuda H, Potapenko I, Hori K, Kume T, Ozaki N.　Biol Pharm Bull.　47　3　591-599　2024
  • 　Chemogenetic inhibition of pain-related neurons in the posterior insula cortex reduces mechanical hyperalgesia and anxiety-like behavior during acute pain.　Potapenko IV, Ishikawa T, Okuda H, Hori K, Ozaki N.　Biochem Biophys Res Commun.　2024

Conference Presentations

  • The role of primary somatosensory cortex in chronic pain.(conference：FAOPS 2015)(2015/11)
  • The role of primary somatosensory cortex in causing mirror image pain(conference：9th FAOPS)(2019/03/28)
  • The role of primary somatosensory cortex in nociception(conference：the 126th Annual Meeting of The Japanese Association of Anatomists　the 98th Annual Meeting of The Physiological Society of Japan)(2021/03/30)
  • Cellular and subcellular distribution of Na/K-ATPase Alpha1 and 3 subunits on the plasma membrane of mouse hippocampal neurons(2024)

Others

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「慢性疼痛発症における一次体性感覚野の役割 ～ニューロン・グリア連関の解明～」(2015-2017)　
○「シナプス内AMPA型グルタミン酸受容体発現密度の生理的意義とメタ可塑性の可視化」(2016-2019)　
○「脳内シナプス結合の構造情報データベースの基盤形成」(2017-2019)　
○「機能性胃腸症における胃の痛覚過敏への、CRF2を介した炎症性サイトカインの関与」(2021-2024)　
○「痛みに応答する一次体性感覚野神経細胞の不安障害及び睡眠障害への影響」(2019-2022)　
○「慢性虚血性疼痛における血管内皮増殖因子のスプライスバリアントの関与について」(2019-2022)　
○「虚血性筋痛における脊髄神経節マクロファージを介した末梢感作機構の解明」(2023-2026)　
○「体性感覚野における慢性疼痛発症機序の解明：痛み刺激に応答する神経細胞の役割」(2023-2025)　

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

○Human Anatomy 2(2023)
○Human Anatomy 1(2023)
○Human Anatomy 2(2023)
○Human Anatomy 1(2023)
○Basic Human Anatomy(2023)
○Human Anatomy(2023)
○Human Anatomy(2023)
○Human Anatomy 2(2022)
○Human Anatomy 1(2022)
○Basic Human Anatomy(2022)
○Human Anatomy 2(2022)
○Human Anatomy 1(2022)
○Human Anatomy(2022)
○Human Anatomy(2022)
○Human Anatomy(2021)
○Human Anatomy(2020)
○Human Anatomy(2019)
○Human Anatomy(2018)

Classes (Graduate Schools)

○Principles of AnatomyⅠ(2023)
○Functional Anatomy(2023)
○Functional Anatomy(2023)
○Functional Anatomy(2023)
○Functional Anatomy(2023)
○Functional Anatomy(2023)
○Functional Anatomy(2023)
○Functional Anatomy(2023)
○Functional Anatomy(2023)
○Functional Anatomy(2023)
○Human Body: Structures a(2023)
○Functional Anatomy(2022)
○Functional Anatomy(2022)
○Functional Anatomy(2022)
○Functional Anatomy(2022)
○Functional Anatomy(2022)
○Functional Anatomy(2022)
○Functional Anatomy(2022)
○Functional Anatomy(2022)
○Functional Anatomy(2022)
○Functional Anatomy(2022)
○Functional Anatomy(2022)
○Functional Anatomy(2022)
○Functional Anatomy(2022)
○Functional Anatomy(2022)
○Functional Anatomy(2022)
○Functional Anatomy(2022)
○Human Body: Structures a(2022)
○Principles of AnatomyⅠ(2022)
○Human Body: Structures b(2021)
○Principles of AnatomyⅠ(2021)
○Functional Anatomy(2021)
○Human Body: Structures a(2021)
○Human Body: Structures b(2020)
○Human Body: Structures a(2020)
○Principles of AnatomyⅡ(2020)
○Principles of AnatomyⅡ(2020)
○Principles of AnatomyⅠ(2020)
○Principles of AnatomyⅠ(2020)
○Functional Anatomy(2020)
○Functional Anatomy(2020)
○Human Body: Structures(2019)
○Functional Anatomy(2019)
○Functional Anatomy(2019)
○Principles of Anatomy(2019)
○Principles of Anatomy(2019)
○Functional Anatomy(2018)
○Functional Anatomy(2018)

International Project

International Students

Lecture themes

Others (Social Activities)

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