last modified：2024/09/21
Assistant Professor KOBAYASHI, Nobuhide
Faculty, Affiliation
Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences
College and School Educational Field
Laboratory
Academic Background
Career
Year & Month of Birth
Academic Society
Award
○Tadamitsu Kishimoto International Travel Award (2019/03)
○Tadamitsu Kishimoto International Travel Award (2019/03)
○Tadamitsu Kishimoto International Travel Award (2019/03)
Specialities
Bacteriology (including mycology)、Immunology、Molecular biology
Speciality Keywords
Clostridium botulinum, Intestinal microbiota, Microfold cell, mucosal immunology, membrane vesicles, organoid
Research Themes
Books
Papers
- Membrane Vesicles Derived From Clostridium botulinum and Related Clostridial Species Induce Innate Immune Responses via MyD88/TRIF Signaling in vitro
Nobuhide Kobayashi, Kimihiro Abe, Sachiyo Akagi, Mayu Kitamura, Yoshitake Shiraishi, Aki Yamaguchi, Masahiro Yutani, Sho Amatsu, Takuhiro Matsumura, Nobuhiko Nomura, Noriyuki Ozaki, Nozomu Obana, Yukako Fujinaga Frontiers in Microbiology 13 2022/02/03
- Osteoprotegerin-dependent M-cell self-regulation balances gut infection and immunity. Kimura S, Nakamura Y, Kobayashi N, Shiroguchi N, Kawakami E, Mutoh M, Takahashi-Iwanaga H, Yamada T, Hisamoto M, Nakamura M, Udagawa N, Sato S, Kaisho T, Iwanaga T, and Hase K Nature communications 11 1 234 2020
- The Roles of Peyer’s Patches and Microfold Cells in the Gut Immune System: Relevance to Autoimmune Diseases. Kobayashi, N., Takahashi, D., Takano, S., Kimura, S. & Hase, K. Frontiers in Immunology 10 2345 2019
- Fasting-Refeeding Impacts Immune Cell Dynamics and Mucosal Immune Responses. Nagai, M., Noguchi, R., Takahashi, D., Morikawa, T., Koshida, K., Komiyama, S., Ishihara, N., Yamada, T., Kawamura, Y., Muroi, K., Hattori, K., Kobayashi, N., Fujimura, Y., Hirota, M., Matsumoto, R., Aoki, R., Tamura-Nakano, M., Sugiyama, M., Katakai, T., Sato, S., Takubo, K., Dohi, T. & Hase, K. Cell 178 5 1072-1087 2019
- Sox8 is essential for M-cell maturation to accelerate IgA response at the early stage after weaning in mice. #Kimura S., #Kobayashi N. (#equal first contribution), Nakamura Y, Kanaya T, Takahashi D, Fujiki R, Mutoh M, Obata Y, Iwanaga T, Nakagawa T, Kato N, Sato S, Kaisho T, Ohno H, Hase K Journal of Experimental Medicine 216 4 831-846 2019
- Altered trafficking of mutated growth factor receptors and their associated molecules: implication for human cancers. Kon S, Kobayashi N, Satake M Cellular Logistics 4 1 e28461 2014
- The Arf GTPase-activating protein SMAP1 promotes transferrin receptor endocytosis and interacts with SMAP2. Kobayashi N, Kon S, Henmi Y, Funaki T, Satake M, Tanabe K Biochem. Biophys. Res. Commun. 453 3 473-479 2014
Conference Presentations
- C. botulinum and related clostridia derived membrane vesicles induce inflammatory responses.(2022/03/29)
- Analysis of host response against membrane vesicles derived from Clostridium botulinum.(conference：The Interagency Botulism Research Coordinating Committee)(2021/10/25)
- Analysis of the interaction between host and Clostridium botulinum derived membrane vesicles.(conference：The 93rd Annual Meeting of Japanese Society for Bacteriology.)(2020/02/19)
- Sox8 is essential for the maturation of M cells and accelerates IgA response at the early stage after weaning.(conference：The 18th Awaji International Forum on Infection and Immunity)(2019/09/12)
- Sox8 is essential for M-cell maturation to accelerate IgA response in the gut.(conference：19th international congress of mucosal immunology)(2019/07/19)
Others
Arts and Fieldwork
Patent
Theme to the desired joint research
Grant-in-Aid for Scientific Research
○「共生細菌による病原性クロストリジウム属菌の腸管感染制御とその機構の解明」(2024-2026)
○「腸内細菌叢が産生する膜小胞が腸管恒常性維持に果たす役割の解明」(2022-2024)
○2021「ボツリヌス菌が産生する膜小胞の病態生理学的意義の解明」(2020-2021)
○「腸管感染型ボツリヌス症を制御する腸内因子のin vivoを中心とした解析」(2021-2023)
○「M細胞の抗原取り込みにおける新規同定輸送関連分子による制御機構の解明」(2019-2020)