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Researcher Information

last modified：2026/06/22

Assistant Professor　ZAIMOKU, Yoshitaka

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University Hospital

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Laboratory

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  • 　Hypomegakaryocytic thrombocytopenia (HMT): an immune-mediated bone marrow failure characterized by an increased number of PNH-phenotype cells and high plasma thrombopoietin levels.　Saito C,Ishiyama K,Yamazaki H,Zaimoku Y,Nakao S　British Journal of Haematology　175　2　246　2016/06　
  • 　Glycosylphosphatidylinositol-specific T cells, IFN-γ-producing T cells, and pathogenesis of idiopathic aplastic anemia.　Gargiulo L,Zaimoku Y,Scappini B,Maruyama H,Ohumi R,Luzzatto L,Nakao S,Notaro R　Blood　129　3　388　2016/11　
  • 　Human herpesvirus-8-unrelated primary effusion lymphoma of the elderly not associated with an increased serum lactate dehydrogenase level: A benign sub-group of effusion lymphoma without chemotherapy.　Zaimoku Y,Takahashi W,Iwaki N,Saito C,Yoshida A,Aoki G,Yamaguchi M,Nakao S　Leukemia & lymphoma　57　7　1625　2016/01　
  • 　IgM anti-recipient ABO antibodies predict acute graft-versus-host disease following allogeneic hematopoietic stem cell transplantation　Yoshitaka Zaimoku,Akiyoshi Takami,Hidehiro Sato,Maki Utsumi,Shinji Nakao　International Journal of Hematology　98　1　96　2013/07
  • 　Identification of an HLA class I allele closely involved in the autoantigen presentation in acquired aplastic anemia.　Zaimoku Y,Takamatsu H,Hosomichi K,Ozawa T,Nakagawa N,Imi T,Maruyama H,Katagiri T,Kishi H,Tajima A,Muraguchi A,Kashiwase K,Nakao S　Blood　129　21　2908　2017/02　

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  • 　ROLE OF IMMUNOGLOBULIN PROPHYLAXIS (0.1g/kg/week) IN HEMATOPOIETIC STEM CELL TRANSPLANT RECIPIENTS: A RETROSPECTIVE ANALYSIS AT A SINGLE INSTITUTE　高松博幸,材木義隆,丸山裕之,細川晃平,斉藤千鶴,清木ゆう,大畑欣也,望月果奈子,小谷岳春,近藤恭夫,山崎宏人,高見昭良,中尾眞二　日本輸血細胞治療学会誌　59　1　43　2013　
  • 　Cyclosporine restores hematopoietic function by compensating for decreased Tregs in patients with pure red cell aplasia and acquired aplastic anemia.　Dao AT,Yamazaki H,Takamatsu H,Sugimori C,Katagiri T,Maruyama H,Zaimoku Y,Maruyama K,Ly TQ,Espinoza L,Nakao S　Annals of Hematology　95　5　771　2016/03　
  • 　Hematopoiesis by iPSC-derived hematopoietic stem cells of aplastic anemia that escape cytotoxic T-cell attack.　Espinoza JL,Elbadry MI,Chonabayashi K,Yoshida Y,Katagiri T,Harada K,Nakagawa N,Zaimoku Y,Imi T,Takamatsu H,Ozawa T,Maruyama H,Nakao S　Blood advances　2　4　390　2018/02/27　
  • 　A comparison of minimal residual disease detection in autografts among ASO-qPCR, droplet digital PCR, and next-generation sequencing in patients with multiple myeloma who underwent autologous stem cell transplantation.　Takamatsu H,Wee RK,Zaimoku Y,Murata R,Zheng J,Moorhead M,Carlton VEH,Kong KA,Takezako N,Ito S,Miyamoto T,Yokoyama K,Matsue K,Sato T,Nakao S　British journal of haematology　183　4　664　2017/12　
  • 　Immune-Mediated Hematopoietic Failure after Allogeneic Hematopoietic Stem Cell Transplantation: A Common Cause of Late Graft Failure in Patients with Complete Donor Chimerism.　Maruyama K,Aotsuka N,Kumano Y,Sato N,Kawashima N,Onda Y,Maruyama H,Katagiri T,Zaimoku Y,Nakagawa N,Hosomichi K,Ogawa S,Nakao S　Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation　24　1　43　2017/08　
  • 　Clinical significance and origin of leukocytes that lack HLA-A allele expression in patients with acquired aplastic anemia.　Maruyama H,Katagiri T,Kashiwase K,Shiina T,Sato-Otsubo A,Zaimoku Y,Maruyama K,Hosokawa K,Ishiyama K,Yamazaki H,Inoko H,Ogawa S,Nakao S　Experimental Hematology　44　10　931　2016/05　
  • 　Haematopoietic regeneration by HLA-A*0206-deficient clones in severe aplastic anaemia without definitive immunosuppressive treatment.　Yoshitaka Zaimoku,Kazuya Sakai,Noriaki Tsuji,Kazuyoshi Hosomichi,Shinya Yamada,Dung Cao Tran,Miku Kobayashi,Ayana Sugiyama,Kouyuki Hirayasu,Hiroki Mizumaki,Ken Ishiyama,Rikinari Hanayama,Yoshiaki Tomiyama,Shinji Nakao　British journal of haematology　205　5　1995　2024/11　
  • 　HLA class I allele-lacking leukocytes predict rare clonal evolution to MDS/AML in patients with acquired aplastic anemia.　Hosokawa K,Mizumaki H,Yoroidaka T,Maruyama H,Imi T,Tsuji N,Urushihara R,Tanabe M,Zaimoku Y,Nguyen MAT,Tran DC,Ishiyama K,Yamazaki H,Nakao S　Blood　137　25　3576　2021/06/24　
  • 　HLA Class I Allele Loss and Bone Marrow Transplantation Outcomes in Immune Aplastic Anemia　Yoshitaka Zaimoku,Takamasa Katagiri,Noriharu Nakagawa,Tatsuya Imi,Hiroyuki Maruyama,Hiroyuki Takamatsu,Ken Ishiyama,Hirohito Yamazaki,Toshihiro Miyamoto,Shinji Nakao　Transplantation and Cellular Therapy　30　3　281.e1-281.e13　2024/03
  • 　Evaluation of a biosimilar granulocyte colony-stimulating factor for peripheral blood stem cell mobilization in Japanese healthy donors: a prospective study.　Sato K,Ishiyama K,Aoki G,Maruyama H,Tsuji N,Tanabe M,Zaimoku Y,Sato H,Yamazaki H,Yamaguchi M,Takami A,Nakao S　International Journal of Hematology　110　6　648　2019/09　
  • 　Sustained clonal hematopoiesis by HLA-lacking hematopoietic stem cells without driver mutations in aplastic anemia.　Imi T,Katagiri T,Hosomichi K,Zaimoku Y,Hoang Nguyen V,Nakagawa N,Tajima A,Yoshizato T,Ogawa S,Nakao S　Blood Advances　2　9　1000　2018/05/08　
  • 　Escape hematopoiesis by HLA-B5401-lacking hematopoietic stem progenitor cells in men with acquired aplastic anemia.　Elbadry MI,Mizumaki H,Hosokawa K,Espinoza JL,Nakagawa N,Chonabayashi K,Yoshida Y,Katagiri T,Hosomichi K,Zaimoku Y,Imi T,Nguyen MAT,Nakao S　Haematologica　104　10　e447　2019/03　
  • 　Culture-negative infective endocarditis due to Neisseria bacilliformis identified via 16S rRNA gene analysis from resected valve tissue: Case report and review of the literature.　Yoshinori Takahashi,Junya Nakade,Yoshitaka Zaimoku,Naoki Watanabe,Tomohisa Watari,Yoshihito Otsuka,Yasunori Iwata,Hajime Kanamori　Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy　31　2　102502　2025/02
  • 　Significance of absolute neutrophil count before allogeneic hematopoietic stem cell transplantation in adult patients with aplastic anemia.　Yukinori Nakamura,Yoshitaka Zaimoku,Hiroki Yamaguchi,Hirohito Yamazaki,Minoru Kanaya,Naoyuki Uchida,Noriko Doki,Masatoshi Sakurai,Nobuhiro Hiramoto,Shinichi Kako,Makoto Onizuka,Koichi Onodera,Yumiko Maruyama,Hiroyuki Ohigashi,Tetsuya Nishida,Satoshi Yoshihara,Ken-Ichi Matsuoka,Tetsuya Eto,Yoshinobu Kanda,Takahiro Fukuda,Yoshiko Atsuta,Yasushi Onishi　Annals of hematology　103　8　3121　2024/08
  • 　Frequent loss of HLA-B*40:02 from leucocytes in male patients with hepatitis-associated aplastic anaemia.　Takamasa Katagiri,Rio Takahashi,Yoshitaka Zaimoku,Kohei Hosokawa,Seishi Ogawa,Yoshiyuki Takahashi,Takako Miyamura,Yasushi Onishi,Takashi Koike,Tetsuya Nishida,Naoyuki Uchida,Noriko Doki,Masatsugu Tanaka,Tetsuya Eto,Mitsuhiro Itagaki,Masashi Sawa,Takahiro Fukuda,Makoto Onizuka,Yoshiko Atsuta,Shinji Nakao　British journal of haematology　205　5　2084　2024/11　
  • 　3D CNN-based Deep Learning Model-based Explanatory Prognostication in Patients  with Multiple Myeloma using Whole-body MRI.　Kento Morita,Shigehiro Karashima,Toshiki Terao,Kotaro Yoshida,Takeshi Yamashita,Takeshi Yoroidaka,Mikoto Tanabe,Tatsuya Imi,Yoshitaka Zaimoku,Akiyo Yoshida,Hiroyuki Maruyama,Noriko Iwaki,Go Aoki,Takeharu Kotani,Ryoichi Murata,Toshihiro Miyamoto,Youichi Machida,Kosei Matsue,Hidetaka Nambo,Hiroyuki Takamatsu　Journal of medical systems　48　1　30　2024/03/08　
  • 　Familial immune-mediated aplastic anaemia in six different families.　Tatsuya Imi,Hiroki Mizumaki,Kazuyoshi Hosomichi,Yasuhito Nannya,Yoshitaka Zaimoku,Takeshi Yoroidaka,Takamasa Katagiri,Ken Ishiyama,Hirohito Yamazaki,Ryosuke Ogawa,Mika Kuroiwa,Atsushi Tajima,Seishi Ogawa,Shinji Nakao　EJHaem　4　3　714　2023/08　
  • 　The effectiveness of immunosuppressive therapy in patients with aplastic anaemia secondary to chemoradiotherapy for cancers　Noriharu Nakagawa,Ken Ishiyama,Mikoto Tanabe,Takeshi Yoroidaka,Hiroki Mizumaki,Tatsuya Imi,Yoshitaka Zaimoku,Hiroyuki Maruyama,Kohei Hosokawa,Hirohito Yamazaki,Shinji Nakao　British Journal of Haematology　195　5　770　2021/12
  • 　Late graft failure with donor-derived GPI-deficient cells in a mixed chimera following allogeneic bone marrow transplantation for severe aplastic anemia.　Hiroo Katsuya,Kyosuke Yamaguchi,Trung Cao Dung,Haruhiko Sano,Hidekazu Itamura,Sho Okamoto,Mariko Yoshimura,Hiroshi Ureshino,Toshihiko Ando,Yoshitaka Zaimoku,Shinji Nakao,Shinya Kimura　Bone marrow transplantation　58　4　465　2023/04
  • 　Deficit of circulating CD19+ CD24hi CD38hi regulatory B cells in severe aplastic anaemia.　Zaimoku Y,Patel BA,Kajigaya S,Feng X,Alemu L,Quinones Raffo D,Groarke EM,Young NS　British Journal of Haematology　190　4　610　2020/04　
  • 　Single-cell analysis of aplastic anemia reveals a convergence of NK and NK-like CD8+ T cells with a disease-associated TCR signature.　Sofie Lundgren,Jani Huuhtanen,Mikko Keränen,Xingmin Feng,Bhavisha A Patel,Georgina L Ryland,Lucy C Fox,Carlos Bravo-Perez,Michael Clemente,Cassandra Kerr,Gunilla Walldin,Olli Dufva,Yoshitaka Zaimoku,Tiina Tuononen,Mikko Myllymäki,Freja Ebeling,Emmi Jokinen,Markus Heinonen,Tiina Kasanen,Jay Klievink,Hanna Lähteenmäki,Taina Jaatinen,Sari Kytölä,Sanna Siitonen,Alina Dulau-Florea,Raul Braylan,Merja Heinäniemi,Shinji Nakao,Eva Hellström-Lindberg,Jaroslaw P Maciejewski,Piers Blombery,Neal S Young,Harri Lähdesmäki,Satu Mustjoki　Science translational medicine　17　787　eadl6758　2025/02/26
  • 　Minor GPI(-) granulocyte populations in aplastic anemia and healthy individuals derived from a few PIGA-mutated hematopoietic stem progenitor cells.　Hiroki Mizumaki,Dung Cao Tran,Kohei Hosokawa,Kazuyoshi Hosomichi,Yoshitaka Zaimoku,Hiroyuki Takamatsu,Hirohito Yamazaki,Ken Ishiyama,Rena Yamazaki,Hiroshi Fujiwara,Atsushi Tajima,Shinji Nakao　Blood cancer journal　13　1　165　2023/11/08
  • 　A Japanese Case of COVID-19 Caused by Omicron Strain with Y453F Substitution.　Hiroka Yamazaki,Yasunori Iwata,Akiko Maekawa,Tomoko Azuma,Yui Shimano,Tadafumi Yokoyama,Junya Nakade,Yasunari Tanaka,Yoko Nakamura,Yoshinori Takahashi,Yoshitaka Zaimoku,Hiroyasu Oe,Megumi Oshima,Mika Mori,Toshifumi Gabata　Rinsho Biseibutsu Jinsoku Shindan Kenkyukai shi = JARMAM : Journal of the Association for Rapid Method and Automation in Microbiology　33　1　19　2023/12/26
  • 　Comparison of Haploidentical Stem Cell Transplantation with Post-Transplantation Cyclophosphamide versus Umbilical Cord Blood Transplantation in Adult Patients with Aplastic Anemia.　Yasushi Onishi,Takehiko Mori,Hirohito Yamazaki,Nobuhiro Hiramoto,Yoshitaka Zaimoku,Minoru Kanaya,Kosei Matsue,Makoto Onizuka,Nobuyuki Aotsuka,Naoyuki Uchida,Koichi Onodera,Junya Kanda,Hirohisa Nakamae,Ryusuke Yamamoto,Takuro Kuriyama,Takafumi Kimura,Tatsuo Ichinohe,Yoshiko Atsuta　Transplantation and cellular therapy　29　12　766.e1-766.e8　2023/12
  • 　Systematic active environmental surveillance successfully identified and controlled the Legionella contamination in the hospital.　Junya Nakade,Yoko Nakamura,Yusuke Katayama,Hiroyuki Obata,Yoshinori Takahashi,Yoshitaka Zaimoku,Yumi Fujii,Yasunori Iwata　Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy　29　1　43　2023/01
  • 　Predictors of clonal evolution and myeloid neoplasia following immunosuppressive therapy in severe aplastic anemia.　Emma M Groarke,Bhavisha A Patel,Ruba Shalhoub,Fernanda Gutierrez-Rodrigues,Parth Desai,Harshraj Leuva,Yoshitaka Zaimoku,Casey Paton,Nina Spitofsky,Jennifer Lotter,Olga Rios,Richard W Childs,David J Young,Alina Dulau-Florea,Cynthia E Dunbar,Katherine R Calvo,Colin O Wu,Neal S Young　Leukemia　36　9　2328　2022/09
  • 　Frequent HLA-DR loss on hematopoietic stem progenitor cells in patients with cyclosporine-dependent aplastic anemia carrying HLA-DR15.　Noriaki Tsuji,Kohei Hosokawa,Ryota Urushihara,Mikoto Tanabe,Yoshitaka Zaimoku,Takamasa Katagiri,Tatsuhiko Ozawa,Hiroyuki Takamatsu,Ken Ishiyama,Hirohito Yamazaki,Hiroyuki Kishi,Seishi Ogawa,Shinji Nakao　Leukemia　36　6　1666　2022/06
  • 　HLA associations, somatic loss of HLA expression, and clinical outcomes in immune aplastic anemia　Yoshitaka Zaimoku,Bhavisha A. Patel,Sharon D. Adams,Ruba Shalhoub,Emma M. Groarke,Audrey Ai Chin Lee,Sachiko Kajigaya,Xingmin Feng,Olga Julia Rios,Holly Eager,Lemlem Alemu,Diego Quinones Raffo,Colin O. Wu,Willy A. Flegel,Neal S. Young　Blood　138　26　2799　2021/12/30
  • 　A frequent nonsense mutation in exon 1 across certain HLA-A and -B alleles in leukocytes of patients with acquired aplastic anemia.　Mizumaki H,Hosomichi K,Hosokawa K,Yoroidaka T,Imi T,Zaimoku Y,Katagiri T,Anh Thi Nguyen M,Cao Tran D,Ibrahim Yousef Elbadry M,Nakao S　Haematologica　106　6　haematol.2020.247809　2021/06　
  • 　Predicting response of severe aplastic anemia to immunosuppression combined with eltrombopag.　Zaimoku Y,Patel BA,Shalhoub R,Groarke EM,Feng X,Wu CO,Young NS　Haematologica　107　1　126　2021/04　
  • 　Prevalence and outcome of VEXAS syndrome in unrelated hematopoietic cell transplantation for bone marrow failure.　Yoshitaka Zaimoku,Tatsuya Imi,Tatsuya Hatada,Hiroki Mizumaki,Hiroki Mura,Hiroki Yoshino,Yui Kano,Miku Kobayashi,Eriko Morishita,Natsumi Fushida,Takashi Matsushita,Keishi Mizuguchi,Hiroko Ikeda,Yasuhito Nannya,Seishi Ogawa,Kazuyoshi Hosomichi,Noriko Doki,Yuta Katayama,Takashi Koike,Ken-Ichi Matsuoka,Tetsuya Nishida,Yoshiyuki Takahashi,Keisuke Kataoka,Hideyuki Nakazawa,Yasunori Ueda,Takahiro Fukuda,Tatsuo Ichinohe,Fumihiko Ishimaru,Makoto Onizuka,Yoshiko Atsuta,Toshihiro Miyamoto　Clinical and experimental medicine　25　1　300　2025/08/22
  • 　Pediatric pneumonia involving Penicillium rolfsii isolated from sputum culture following a plunge pool near-drowning incident.　Shiori Kitaya,Akira Watanabe,Takashi Yaguchi,Junya Nakade,Hatsumi Otani,Yusuke Matsuda,Tatsuya Kubo,Tomoko Azuma,Yui Ikehata,Hiroki Otani,Hiroka Yamazaki,Daichi Miyashita,Yasunari Tanaka,Yoshinori Takahashi,Yoshitaka Zaimoku,Megumi Oshima,Taizo Wada,Takumi Taniguchi,Hajime Kanamori　Journal de mycologie medicale　35　4　101589　2025/12
  • 　Phase II study of the triple combination of rabbit ATG, ciclosporin and eltrombopag in patients with transfusion-dependent aplastic anaemia: West Japan Hematology Study Group (W-JHS) AA02 trial.　Fumi Nakamura,Ken Ishiyama,Ritsuro Suzuki,Hiroyuki Maruyama,Yasushi Onishi,Kensuke Usuki,Hideo Koh,Katsuto Takenaka,Ryunosuke Saiki,Seishi Ogawa,Kana Matsumoto,Takuto Takahashi,Kazuyoshi Hosomichi,Yoshitaka Zaimoku,Kenichi Yoshimura,Itaru Matsumura,Koichi Akashi,Shinji Nakao　British journal of haematology　2026/01/04
  • 　Transient lupus anticoagulant induced by adenovirus cystitis in a bone marrow transplant recipient.　Tatsuya Imi,Hidesaku Asakura,Keijiro Sato,Shinya Yamada,Takeshi Yoroidaka,Yoshitaka Zaimoku,Hiroyuki Maruyama,Kohei Hosokawa,Akiyo Yoshida,Hiroyuki Takamatsu,Ken Ishiyama,Hirohito Yamazaki,Hikaru Kobayashi,Shinji Nakao,Toshihiro Miyamoto　International journal of hematology　2025/06/05
  • 　Loss‐Prone HLA Class I Alleles Inform Outcomes of Early Hematopoietic Cell Transplantation in Acquired Aplastic Anemia　Yoshitaka Zaimoku,Hirohito Yamazaki,Minoru Kanaya,Nobuhiro Hiramoto,Ken Ishiyama,Katsuto Takenaka,Makoto Murata,Naoyuki Uchida,Noriko Doki,Ryusuke Yamamoto,Testuya Nishida,Koichi Onodera,Shinichiro Machida,Yoshinobu Kanda,Tetsuya Eto,Keisuke Kataoka,Noboru Asada,Mitsuhiro Itagaki,Mamiko Sakata‐Yanagimoto,Fumihiko Ishimaru,Makoto Onizuka,Tatsuo Ichinohe,Yoshiko Atsuta,Yasushi Onishi　American Journal of Hematology　2025/12
  • 　The contribution of metagenomic next-generation sequencing to a diagnosis of gas-producing Fusobacterium-induced septic hip arthritis: A case report.　Shiori Kitaya,Kazuhiro Horiba,Tamon Kabata,Takahiro Iyobe,Masanori Hashino,Hiroka Yamazaki,Yoshinori Takahashi,Yoshitaka Zaimoku,Megumi Oshima,Hajime Kanamori　Journal of infection and chemotherapy : official journal of the Japan Society of Chemotherapy　31　4　102681　2025/04
  • 　iPSC-derived modeling of HLA-lacking hematopoiesis reveals clonal diversity in eltrombopag response in acquired aplastic anemia.　Honoka Takahashi,Luna Seoka,Rio Takahashi,Yoshinori Yoshida,Kazuhisa Chonabayashi,Katsuto Takenaka,Koichi Akashi,Hiroyuki Takamatsu,Tatsuya Imi,Yoshitaka Zaimoku,Kohei Hosokawa,Takamasa Katagiri　Stem cells (Dayton, Ohio)　2026/01/24
  • 　Infection in glaucoma drainage implant caused by macrolide-resistant Mycobacterium abscessus subsp. abscessus.　Shiori Kitaya,Ryotaro Wajima,Yoshitaka Zaimoku,Hatsumi Otani,Tomomi Higashide,Hajime Kanamori　Diagnostic microbiology and infectious disease　113　4　117060　2025/12
  • 　Interferon-γ-mediated selective inhibition of hematopoiesis and the clonal advantage of HLA-lacking hematopoietic stem progenitor cells in aplastic anemia.　Rio Takahashi,Honoka Takahashi,Luna Seoka,Hiroka Iwasaki,Hiroyuki Takamatsu,Tatsuya Imi,Yoshitaka Zaimoku,Kohei Hosokawa,Takamasa Katagiri　Leukemia　39　6　1490　2025/06

Conference Presentations

  • Prevalence, clinical features, and outcomes of VEXAS syndrome in hematology clinic(2025/10)
  • Role of HLA in AA(conference：8th International Bone Marrow Failure Disease Scientific Symposium)(2022/05/19)
  • HLA Class I Allele-Deficient Clones Enable Durable Hematopoietic Regeneration without Anti-Thymocyte Globulin in Immune Aplastic Anemia(2026/01/17)
  • Multiple HLA-loss clones are required for hematologic regeneration in immune aplastic anemia(conference：67TH ASH ANNUAL MEETING AND EXPOSITION)(2025/12/06)
  • HLA loss in aplastic anemia(conference：The 87th Annual Meeting of the Japanese Society of Hematology)(2025/10/10)

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  • Immune escape and hematopoietic regeneration in aplastic anemia(2025/01/17)
  • The Copy Number of Disease-Associated HLA Alleles Predicts the Response to Immunosuppressive Therapy in Acquired Aplastic Anemia(conference：63rd ASH Annual Meeting and Exposition)(2021/12/13)

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