本文へジャンプ

研究者情報

データ更新日:2017年05月30日

佐々木 素子 (ささき もとこ) 准教授 SASAKI Motoko

メール

所属組織・役職等

医薬保健研究域 医学系 人体病理学

教育分野

【学士課程】
医薬保健学域 医学類
医薬保健学域 医学類 病態の形態と機構機序(分担)
【大学院前期課程】
医薬保健学総合研究科 医科学専攻
【大学院後期課程】
医薬保健学総合研究科 がん医科学専攻

所属研究室等

 TEL:076-265-2197 FAX:076-234-4229

学歴

【出身大学院】
金沢大学 博士課程 医学研究科 病理学第2 1989 その他
【出身大学】
金沢大学 医学部 医学科 1988
【取得学位】
医学博士

職歴

生年月

所属学会

日本病理学会 評議員(1996-)
日本肝臓学会 評議員
日本胆道学会 評議員
日本肝癌研究会 幹事
日本臨床細胞学会 評議員
International Academy of Pathology (IAP)
日本組織細胞化学会

学内委員会委員等

○ヒトゲノム・遺伝子解析研究倫理審査委員会 委員(2014-2015)

受賞学術賞

○肝臓学会研究奨励賞(1994)
○北國がん基金研究助成 (2006)
○日本病理学会学術研究賞 (2009)
○金沢医学館記念医学賞 (2009)

専門分野

人体病理学、肝胆道系疾患の病理

専門分野キーワード

肝胆道病理、原発性胆汁性肝硬変、胆管癌

研究課題

原発性胆汁性胆管炎の病因解明

肝内結石症に合併する肝内胆管癌の発生・進展に関する免疫組織化学的検討

肝胆道系疾患における細胞老化とオートファジーの関与

肝胆道系疾患とムチンコア蛋白の変動

著書

  • 胆道疾患を診る医師のための胆道病理テキスト 南江堂, 東京 2015/01/01 原著書 単著 佐々木素子
  • 胆道疾患を診る医師のための胆道病理テキスト  南江堂, 東京 2015/01/01 原著書 単著 佐々木 素子
  • 胆道疾患を診る医師のための胆道病理テキスト  南江堂, 東京 2015/01/01 原著書 単著 佐々木 素子
  • AUTOPHAGY: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging. 2013/01/01 原著書 共著
  • C型肝炎の診療を極める。〜基本から最前線まで〜  文光堂, 東京 2014/01/01 原著書 共著 佐々木 素子,中沼 安二

全て表示

  • 専門医のための消化器病学 第2版 2013/01/01 原著書 共著 佐々木 素子,中沼 安二
  • 臨床医が知っておきたい消化器病理の見かたのコツ 羊土社, 東京 2013/01/01 原著書 単著 佐々木 素子
  • キーワードとアルゴリズムで捉える:肝胆膵の実践病理 診断 文光堂, 東京 2013/01/01 共著 中沼 安二,  佐々木 素子
  • 肝臓を診る医師のための肝臓病理テキスト  南江堂, 東京 2013/01/01 単著 佐々木 素子
  • 腫瘍病理鑑別診断アトラス 肝癌  文光堂, 東京 2010/01/01 単著 佐々木 素子
  • 肝・胆・膵フロンティア11:肝胆膵癌の境界病変-病理的見地からの再検討.  2000/01/01 原著書 共著 中沼 安二,原田 憲一,佐々木 素子
  • 第4回大塚リバーシンポジュウム: 原発性胆汁性肝硬変 メディカルレビュ−社, 東京 2000/01/01 原著書 共著 中沼 安二,原田 憲一,常山 幸一,佐々木 素子
  • 生検鑑別診断アトラス:肝結節の生検診断 文光堂, 東京 1998/01/01 原著書 単著 佐々木素子
  • 生検鑑別診断アトラス:肝結節の生検診断 文光堂, 東京 1998/01/01 原著書 単著 佐々木素子
  • 生検鑑別診断アトラス:肝結節の生検診断  文光堂, 東京 1998/01/01 原著書 単著 佐々木 素子
  • 自己免疫性肝疾患 -病態と治療- 診断と治療社, 東京 1996/01/01 原著書 共著 中沼 安二,原田 憲一,佐々木 素子,鍛冶 恭介,太田 肇
  • 胆道の閉塞性疾患:消化器診療プラクテイス9 文光堂, 東京 1994/01/01 原著書 共著 中沼 安二,佐々木 素子,寺田 忠史
  • 取扱規約に沿った腫瘍鑑別診断アトラス「肝臓」 文光堂, 東京 1991/01/01 原著書 共著 佐々木 素子,中沼 安二
  • Cancer, etiology, diagnosis and treatments. 2011/01/01 原著書 共著
  • Advances in Medicine and Biology. Volume 7. (ed. Berhardt, LV). Chapter V- Primary biliary cirrhosis: Pathology and pathogenesis 2010/01/01 原著書 共著
  • Tumor necrosis factor (ed.TP Rossard). Tumor necrosis factor-α and biliary tract diseases. 2009/01/01 原著書 共著

論文

  • Frequent cellular senescence in small bile ducts in primary biliary cirrhosis: a possible role in bile duct loss.  Sasaki M, Ikeda H, Haga H, et al Journal of Pathology 205巻 4号 451-459頁 2005/03 査読有 原著論文 研究論文(学術雑誌)
  • Telomere shortening in the damaged small bile ducts in primary biliary cirrhosis reflects ongoing cellular senescence. 48巻 186-195頁 2008/07 査読有 原著論文 研究論文(学術雑誌)
  • A possible involvement of endoplasmic reticulum stress in biliary epithelial autophagy and senescence in primary biliary cirrhosis Journal of Gastroenterology 2015/01/01 
  • Immunostaining for polycomb group protein EZH2 and senescent marker p16INK4a may be useful to differentiate cholangiolocellular carcinoma from ductular reaction and bile duct adenoma American Journal of Surgical Pathology 38巻 3号 364-369頁 2014/03/01 
  • KRAS and GNAS mutations and p53 overexpression in biliary intraepithelial neoplasia and intrahepatic cholangiocarcinomas Cancer 119巻 9号 1669-1674頁 2013/05/01 

全て表示

  • A serum amyloid A-positive hepatocellular neoplasm arising in alcoholic cirrhosis: A previously unrecognized type of inflammatory hepatocellular tumor Modern Pathology 25巻 12号 1584-1593頁 2012/12/01 
  • Increased expression of mitochondrial proteins associated with autophagy in biliary epithelial lesions in primary biliary cirrhosis Liver International 33巻 2号 312-320頁 2013/02/01 
  • Pathogenesis of Bile Duct Lesions in Primary Biliary Cirrhosis: Role of Autophagy Followed by Cellular Senescence Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging 293-303頁 2013/10/01 
  • Autophagy may precede cellular senescence of bile ductular cells in ductular reaction in primary biliary cirrhosis Digestive Diseases and Sciences 57巻 3号 660-666頁 2012/03/01 
  • Overexpression of enhancer of zeste homolog 2 and MUC1 may be related to malignant behaviour in intraductal papillary neoplasm of the bile duct Histopathology 62巻 3号 446-457頁 2013/02/01 
  • Site-characteristic expression and induction of trefoil factor family 1, 2 and 3 and malignant brain tumor-1 in normal and diseased intrahepatic bile ducts relates to biliary pathophysiology. Sasaki M, Tsuneyama K, Saito T, et al. Liver International 24巻 1号 29-37頁 2004/02 査読有 原著論文 研究論文(学術雑誌)
  • 【肝細胞癌のすべて2012】 肝細胞癌の病理 佐々木, 素子;中沼, 安二 肝・胆・膵 65巻 6号 1055-1062頁 2012
  • 原発性胆汁性肝硬変の胆管病変におけるミトコンドリア蛋白の発現 佐々木, 素子;宮腰, 茉沙美;佐藤, 保則;中沼, 安二 消化器と免疫 3巻 48号 135-139頁 2012
  • 【胆嚢を究める】 基礎 胆嚢発癌と病理(合流異常を含む) 中沼, 安二;山口, 淳平;佐々木, 素子;佐藤, 保則 外科 73巻 5号 473-478頁 2011
  • 【混合型肝癌および胆管形質を示す肝細胞癌:肝ステム細胞のインパクト】 混合型肝癌(新who分類を中心に) 病理 混合型肝癌の病理 Whoの新たなチャレンジ 周辺腫瘍との異同、比較を含めて 佐々木, 素子;中沼, 安二 肝・胆・膵 63巻 4号 615-623頁 2011
  • 【肝門部~肝内胆管癌】 肝門部~肝内胆管癌の病理 佐々木, 素子;中沼, 安二 臨床消化器内科 26巻 13号 1691-1697頁 2011
  • 【胆道画像診断のコモンセンス】 胆道の病理(胆嚢を除く) 膵カウンターパートとの比較を中心に 中沼, 安二;Hsu, Malyee;佐々木, 素子;佐藤, 保則;原田, 憲一 画像診断 31巻 3号 266-277頁 2011
  • 【肝内胆管、胆道、膵の腫瘍分類 Whoの新たな試みを含めて】 肝内胆管、胆道、膵 共通の視点に立った腫瘍発生 病理・発癌の観点から 中沼, 安二;Hsu, Malyee;佐々木, 素子;佐藤, 保則;原田, 憲一 肝・胆・膵 62巻 1号 17-28頁 2011
  • 【混合型肝癌および胆管形質を示す肝細胞癌:肝ステム細胞のインパクト】 混合型肝癌(新who分類を中心に) サブタイプ 細胆管癌の病理 肝ステム細胞との関連 佐々木, 素子;中沼, 安二 肝・胆・膵 63巻 4号 625-633頁 2011
  • 【腫瘍栓のすべて】 病理、腫瘍マーカー、画像 胆管細胞癌 腫瘍栓の病理 佐々木, 素子;中沼, 安二 外科 70巻 2号 134-137頁 2008
  • 【肝幹細胞をめぐる最近の知見】 肝幹細胞とtumor-initiating cells 肝幹細胞と細胆管癌 佐々木, 素子;中沼, 安二 肝・胆・膵 57巻 3号 445-452頁 2008
  • 【本邦における非b非c肝癌の実態】 非b非c肝癌の病理学的特徴 B型、C型との比較 澤田, 星子;佐々木, 素子;中沼, 安二 肝・胆・膵 54巻 3号 393-402頁 2007
  • 【胆管障害とその修復・治療の最近の進歩】 胆管・発生の基礎的展開 胆管上皮のヘテロジェナィティ 中沼, 安二;池田, 博子;原田, 憲一;一瀬, 久美子;佐々木, 素子 肝・胆・膵 55巻 3号 391-399頁 2007
  • 【肝胆膵での粘液産生腫瘍と嚢胞性腫瘍】 類縁疾患 肝胆膵の粘液癌 胆管内乳頭状腫瘍ipn-Bおよび膵ipmtとの関連性を中心に 中沼, 安二;北川, 諭;佐々木, 素子;全, 陽 肝・胆・膵 52巻 2号 251-258頁 2006
  • 【肝がん治療のすべて】 肝内胆管癌 肝内胆管癌 病理形態からみたその発生 中沼, 安二;佐々木, 素子;全, 陽 肝・胆・膵 53巻 5号 973-982頁 2006
  • 【高齢化時代を迎えた肝臓病 高齢化の実態と対策】 肝細胞の老化 老化関連マーカーの発現 佐々木, 素子;中沼, 安二 肝・胆・膵 53巻 1号 67-72頁 2006
  • 【非B非C型肝炎】 非B非C型肝硬変(cryptogenic cirrhosis)の病理学 佐々木, 素子;中沼, 安二 臨床消化器内科 21巻 12号 1637-1644頁 2006
  • 【肝門部胆管癌治療 現状の評価と今後の課題】 肝門部胆管癌の病理学的進展様式 佐々木, 素子;中沼, 安二 肝・胆・膵 50巻 3号 427-433頁 2005
  • 【肝胆膵領域における腫瘍性病変の画像と病理】 典型例の画像と病理 肝腫瘍 肝血管肉腫の画像と病理 澤田, 星子;高川, 清;家城, 恭彦;荒井, 和徳;小坂, 一斗;佐々木, 素子;中沼, 安二 肝・胆・膵 49巻 5号 612-617頁 2004
  • 各種抗不整脈薬抵抗性の心室頻拍を呈し,経皮的心肺補助を施行したにも関らず死亡した下痢を前駆症状とする急性心筋炎の1例 紺谷, 真;泉谷, 省晶;安間, 圭一;池田, 孝之;佐々木, 素子;中沼, 安二 心臓 34巻 Suppl.3号 28-33頁 2002
  • 【肝胆膵癌の病期分類 取扱い規約改訂における論点】 「肝癌取扱い規約」第4版改訂への課題 肝内胆管癌取扱い規約(第4版)と今後(第4版以降)の課題 病理からの論点 中沼, 安二;佐々木, 素子 肝・胆・膵 41巻 4号 503-512頁 2000
  • 【肝胆膵癌の境界病変 病理的見地からの再検討】 肝癌の境界病変 病理 肝内胆管癌の境界病変 中沼, 安二;原田, 憲一;佐々木, 素子 肝・胆・膵フロンティア 10巻 11号 24-29頁 2000
  • 【肝内結石症研究の最前線】 肝内結石症とヘリコバクター感染 天谷, 奨;平松, 活志;片柳, 和義;佐々木, 素子;中沼, 安二 胆と膵 19巻 11号 1051-1054頁 1998
  • 【肝内結石症の病態と治療】 肝内結石症の肝組織の病理 安. 常. 中沼, 幸一;河野, 尚子;佐々木, 素子 消化器外科 21巻 9号 1443-1448頁 1998
  • 原発性硬化性胆管炎の病理 中沼, 安二;常山, 幸一;河野, 尚子;佐々木, 素子 胆と膵 17巻 9号 799-804頁 1996
  • 胆管上皮にmuc1ムチンコア蛋白の異常発現を認めた成人型肝腎多発嚢胞性疾患の1剖検例 小泉, 博志;佐々木, 素子;中沼, 安二 病理と臨床 14巻 3号 379-382頁 1996
  • 【自己免疫性胆管疾患のオーバーラップス PBC/AIH、PSC/AIHとPSC/IgG4関連硬化性胆管炎を中心に】 PBCとその類縁疾患、オーバーラップス 基礎 細胞老化と胆管障害、細胆管反応 佐々木, 素子;中沼, 安二 肝・胆・膵 62巻 4号 657-663頁 2011
  • C型慢性肝炎肝組織にみられる樹状突起細胞 原発性胆汁性肝硬変(Pbc)との比較検討 中沼, 安二;細, 正博;佐々木, 素子 消化器と免疫 8巻 31号 228-232頁 1995
  • 【肝細胞腺腫、Fnhと周辺病変の新しい考え方】 肝細胞腺腫とfnhの画像診断 肝細胞腺腫、Fnhと周辺病変の画像(Eob-Mri) 米田, 憲秀;松井, 修;小林, 聡;北尾, 梓;小坂, 一斗;佐々木, 素子;中沼, 安二;蒲田, 敏文 肝・胆・膵 69巻 5号 757-769頁 2014
  • 【修復の病理学】 病理像修復後の新たな病態発生 Banti病、incomplete septal cirrhosis、乙'型肝硬変 病態解析の新たなアプローチ 筒井, 朱美;中沼, 安二;北村, 星子;池田, 博子;佐々木, 素子 肝・胆・膵 68巻 5号 771-779頁 2014
  • 【胆道癌として外科切除された鑑別困難病変の検証-画像と病理所見の対比-】 BilINから胆管癌への移行の観点から見た病理学的課題 佐々木, 素子;中沼, 安二 胆と膵 35巻 3号 227-232頁 2014
  • 【Nafld/Nash;肝発癌に至る病態と対策】 Nafld/Nashの疫学・病理 Nafld/Nashの病理診断 活動度、病期分類 佐々木, 素子;中沼, 安二 肝・胆・膵 69巻 3号 307-312頁 2014
  • 【いわゆる「早期胆嚢癌」に関する問題点を整理する】 胆管内乳頭状腫瘍ipnbの胆嚢病変について 佐々木, 素子;中沼, 安二 胆と膵 35巻 9号 795-800頁 2014
  • 【肝細胞腺腫、Fnhと周辺病変の新しい考え方】 肝細胞腺腫 疫学、遺伝子異常 遺伝子異常 佐々木, 素子;中沼, 安二 肝・胆・膵 69巻 5号 695-701頁 2014
  • 【肝細胞腺腫、FNHと周辺病変の新しい考え方】 肝細胞腺腫、FNHおよび周辺病変の病理 アルコール性肝硬変に発生する肝細胞腺腫、FNH類似病変 Serum amyloid A陽性肝細胞性腫瘍 佐々木, 素子;中沼, 安二 肝・胆・膵 69巻 5号 731-738頁 2014
  • 【胆膵癌の早期診断フロントライン】 胆道(胆嚢、胆管) 早期胆道癌(胆嚢と胆管)の分子病理 中沼, 安二;佐々木, 素子;佐藤, 保則 肝・胆・膵 66巻 2号 171-180頁 2013
  • 【いわゆる良性腫瘍のマリグナントプログレッション】 肝細胞性腫瘍:肝細胞腺腫/過形成結節と癌化 肝細胞腺腫の亜型と癌化の病理 佐々木, 素子;中沼, 安二 肝・胆・膵 65巻 3号 449-455頁 2012
  • 臨床に役立つ肝臓病理 生検材料による肝疾患の病理診断 病型判定と鑑別診断 自己免疫性肝疾患 細, 正博;原田, 憲一;佐々木, 素子 肝・胆・膵 33巻 4号 527-531頁 1996
  • 肝癌の病態 多発性発癌と肝内転移の分子機構-病理学的観点から 安. 細. 中沼, 正博;佐々木, 素子 Modern Physician 15巻 11号 1441-1445頁 1995
  • 【PSC・IgG4-SC】 PSC・IgG4-SC病理診断 PSCの病理診断 中沼, 安二;佐々木, 素子;佐藤, 保則;原田, 憲一 肝・胆・膵 68巻 1号 42995頁 2014
  • 目で見る肝癌 大酒家のC型肝硬変症例に発症した多血性過形成結節(serum amyloid A陽性肝細胞性腫瘍)の1例 澤井, 良之;今井, 康陽;佐々木, 素子 The Liver Cancer Journal 6巻 3号 148-153頁 2014
  • 【肝胆膵分野の再生医療・人工臓器】 胆 胆管ステム細胞 佐々木素子 肝・胆・膵 70巻 3号 395-403頁 2015
  • 【最新肝癌学-基礎と臨床の最新研究動向-】 肝癌の病理・病態 通常型肝細胞癌の病理 佐々木素子 日本臨床 73巻 増刊1 最新肝癌学号 251-254頁 2015
  • 【コランギオパチー】 コランギオパチーに対する新しい考え方 細胞老化とコランギオパチー 佐々木, 素子;中沼, 安二 肝・胆・膵 71巻 5号 805-812頁 2015
  • 【コランギオパチー】 腫瘍性コランギオパチー(胆管腫瘍) 胆管癌とオートファジー 新田, 健雄;佐藤, 保則;佐々木, 素子;原田, 憲一;平野, 聡;中沼, 安二 肝・胆・膵 71巻 5号 905-910頁 2015
  • 【肝良性腫瘍および類似病変の病理・画像診断update】 肝細胞腺腫とFNH-like nodule 米田, 憲秀;松井, 修;小林, 聡;北尾, 梓;小坂, 一斗;佐々木, 素子;蒲田, 敏文 画像診断 35巻 2号 197-206頁 2015
  • 【肝胆膵疾患とオートファジー】 オートファジー異常と肝胆膵疾患 原発性胆汁性胆管炎(primary biliary cholangitis:PBC) オートファジー異常の関与 佐々木素子 肝・胆・膵 73巻 2号 207-213頁 2016
  • 画像診断と病理 脂肪肝かnashか? 画像でどこまでわかるの? 佐々木素子 肝臓クリニカルアップデート 1巻 1号 83-87頁 2015
  • 画像診断と病理 小さいが外科切除した方が良い、肝癌の特徴は? Vp1をどこまで読めるか 門脈侵襲を伴う肝癌の病理学的特徴 佐々木素子 肝臓クリニカルアップデート 1巻 2号 229-232頁 2015
  • 【難治な胆道良性疾患の対処法を考える】 難治な胆道良性疾患の対処法を考える 宮崎, 勝;糸井, 隆夫;潟沼, 朗生;佐々木, 素子 肝・胆・膵 71巻 3号 527-539頁 2015
  • [Pathological study of hepatolithiasis with special reference to unusual cases] Y. O. Nakanuma, G.;Yamaguchi, K.;Koga, A.;Yamamoto, K.;Sasaki, M.;Doishita, K.;Yoshikawa, T.;Hanyu, F.;Takahashi, W.;et al., Nihon Geka Gakkai Zasshi 85巻 9号 1114-8頁 1984
  • Expression of blood group-related antigens in the intrahepatic biliary tree and hepatocytes in normal livers and various hepatobiliary diseases Y. S. Nakanuma, M. Hepatology 10巻 2号 174-8頁 1989
  • Fatty macroregenerative nodule in non-steatotic liver cirrhosis. A morphologic study T. N. Terada, Y.;Hoso, M.;Saito, K.;Sasaki, M.;Nonomura, A. Virchows Arch A Pathol Anat Histopathol 415巻 2号 131-6頁 1989
  • Amyloid deposition in intrahepatic large bile ducts and peribiliary glands in systemic amyloidosis M. N. Sasaki, Y.;Terada, T.;Hoso, M.;Saito, K.;Hayashi, M.;Kurumaya, H. Hepatology 12巻 4 Pt 1号 743-6頁 1990
  • Anorectal mucinous adenocarcinoma associated with latent perianal Paget's disease M. T. Sasaki, T.;Nakanuma, Y.;Kono, N.;Kasahara, Y.;Watanabe, K. Am J Gastroenterol 85巻 2号 199-202頁 1990
  • Intrahepatic cholangiocarcinoma with sarcomatous transformation: an autopsy case M. N. Sasaki, Y.;Nagai, Y.;Nonomura, A. J Clin Gastroenterol 13巻 2号 220-5頁 1991
  • Pathology of the spleen in primary biliary cirrhosis: an autopsy study N. M. Terayama, K. P.;Kobayashi, S.;Nakanuma, Y.;Sasaki, M.;Saito, K.;Katayanagi, K. Pathol Int 44巻 43019号 753-8頁 1994
  • Hemosiderin deposition in portal endothelial cells: a novel hepatic hemosiderosis frequent in chronic viral hepatitis B and C K. N. Kaji, Y.;Sasaki, M.;Unoura, M.;Kobayashi, K.;Nonomura, A. Hum Pathol 26巻 10号 1080-5頁 1995
  • Expression of glycoconjugates during intrahepatic bile duct development in the rat: an immunohistochemical and lectin-histochemical study T. Y. Sanzen, K.;Sasaki, M.;Terada, T.;Nakanuma, Y. Hepatology 22巻 3号 944-51頁 1995
  • Hepatocellular prolapse of hepatic portal tracts and subendothelial space of central veins in idiopathic portal hypertension M. N. Sasaki, Y.;Watanabe, K. Histopathology 27巻 1号 67-70頁 1995
  • Biliary epithelial expression of MUC1, MUC2, MUC3 and MUC5/6 apomucins during intrahepatic bile duct development and maturation. An immunohistochemical study M. N. Sasaki, Y.;Terada, T.;Kim, Y. S. Am J Pathol 147巻 3号 574-9頁 1995
  • Pathological and immunohistochemical findings in a case of mucinous cholangiocarcinoma M. N. Sasaki, Y.;Shimizu, K.;Izumi, R. Pathol Int 45巻 10号 781-6頁 1995
  • [Intrahepatic sarcomatoid cholangiocarcinoma] M. T. Sasaki, T.;Nakanuma, Y. Ryoikibetsu Shokogun Shirizu 7号 408-10頁 1995
  • [Mucinous cholangiocarcinoma] M. T. Sasaki, T.;Nakanuma, Y. Ryoikibetsu Shokogun Shirizu 7号 423-5頁 1995
  • Neoexpression of Lewis Y antigen is a sensitive phenotypic change of the damaged intrahepatic bile ducts M. K. Sasaki, N.;Nakanuma, Y. Hepatology 19巻 1号 138-44頁 1994
  • Hepatitic bile duct injuries in chronic hepatitis C: histopathologic and immunohistochemical studies K. N. Kaji, Y.;Sasaki, M.;Unoura, M.;Kobayashi, K.;Nonomura, A.;Tsuneyama, K.;Van de Water, J.;Gershwin, M. E. Mod Pathol 7巻 9号 937-45頁 1994
  • Intrahepatic peribiliary glands of humans. II. Pathological spectrum Y. S. Nakanuma, M.;Terada, T.;Harada, K. J Gastroenterol Hepatol 9巻 1号 29373頁 1994
  • Expression of mucin core protein of mammary type in primary liver cancer M. N. Sasaki, Y. Hepatology 20巻 5号 1192-7頁 1994
  • Membranous expression of Lewis Y antigen in clustered hepatocytes in chronic viral, autoimmune, and alcoholic liver diseases but not in biliary diseases M. K. Sasaki, N.;Nakanuma, Y. Mod Pathol 7巻 3号 339-46頁 1994
  • Histopathology of the liver in non-cirrhotic portal hypertension of unknown aetiology Y. H. Nakanuma, M.;Sasaki, M.;Terada, T.;Katayanagi, K.;Nonomura, A.;Kurumaya, H.;Harada, A.;Obata, H. Histopathology 28巻 3号 195-204頁 1996
  • Multinodular deposition of AA-type amyloid localized in the adrenal glands of an old man M. K. Sasaki, N.;Nakanuma, Y.;Ishiura, Y. Acta Pathol Jpn 42巻 12号 893-6頁 1992
  • Hilar cholangiocarcinoma (Klatskin tumor) arising from intrahepatic peribiliary glands T. S. Terada, M.;Nakanuma, Y.;Takeda, Y.;Masunaga, T. J Clin Gastroenterol 15巻 1号 79-81頁 1992
  • Succinylated wheat germ agglutinin lectin binding in intrahepatic vessels. A new histochemical tool Y. S. Nakanuma, M.;Kono, N. Arch Pathol Lab Med 117巻 8号 809-11頁 1993
  • Pseudolipoma of Glisson's capsule. Report of six cases and review of the literature M. H. Sasaki, K.;Nakanuma, Y.;Watanabe, K. J Clin Gastroenterol 19巻 1号 27607頁 1994
  • Destruction of bile ducts in primary biliary cirrhosis Y. T. Nakanuma, K.;Sasaki, M.;Harada, K. Baillieres Best Pract Res Clin Gastroenterol 14巻 4号 549-70頁 2000
  • Expression of MUC1 and MUC2 and carbohydrate antigen Tn change during malignant transformation of biliary papillomatosis S. S. Amaya, M.;Watanabe, Y.;Tsui, W. M.;Tsuneyama, K.;Harada, K.;Nakanuma, Y. Histopathology 38巻 6号 550-60頁 2001
  • Immunohistochemical analysis of cell-matrix adhesion molecules and their ligands in the portal tracts of primary biliary cirrhosis M. T. Yasoshima, K.;Harada, K.;Sasaki, M.;Gershwin, M. E.;Nakanuma, Y. J Pathol 190巻 1号 34213頁 2000
  • B7-2 positive cells around interlobular bile ducts in primary biliary cirrhosis and chronic hepatitis C K. T. Kaji, K.;Nakanuma, Y.;Harada, K.;Sasaki, M.;Kaneko, S.;Kobayashi, K. J Gastroenterol Hepatol 12巻 7号 507-12頁 1997
  • Expression of MAGE-A3 in intrahepatic cholangiocarcinoma and its precursor lesions K. S. Tsuneyama, M.;Shimonishi, T.;Nakanuma, Y. Pathol Int 54巻 3号 181-6頁 2004
  • Site-characteristic expression and induction of trefoil factor family 1, 2 and 3 and malignant brain tumor-1 in normal and diseased intrahepatic bile ducts relates to biliary pathophysiology M. T. Sasaki, K.;Saito, T.;Kataoka, H.;Mollenhauer, J.;Poustka, A.;Nakanuma, Y. Liver Int 24巻 1号 29-37頁 2004
  • Expression of trefoil factor family 1, 2, and 3 peptide is augmented in hepatolithiasis M. I. Sasaki, H.;Ohira, S.;Ishikawa, A.;Nakanuma, Y. Peptides 25巻 5号 763-70頁 2004
  • Retroperitoneal mucinous cystadenoma: report of two cases and review of the literature K. H. Isse, K.;Suzuki, Y.;Ishiguro, K.;Sasaki, M.;Kajiura, S.;Nakanuma, Y. Pathol Int 54巻 2号 132-8頁 2004
  • Expression of MUC apomucins in normal pancreas and pancreatic tumours T. O. Terada, T.;Sasaki, M.;Nakanuma, Y.;Kim, Y. S. J Pathol 180巻 2号 160-5頁 1996
  • Aberrant expression of CDX2 is closely related to the intestinal metaplasia and MUC2 expression in intraductal papillary neoplasm of the liver in hepatolithiasis A. S. Ishikawa, M.;Ohira, S.;Ohta, T.;Oda, K.;Nimura, Y.;Chen, M. F.;Jan, Y. Y.;Yeh, T. S.;Nakanuma, Y. Lab Invest 84巻 5号 629-38頁 2004
  • Intrahepatic cholangiocarcinoma arising in autosomal dominant polycystic kidney disease M. K. Sasaki, K.;Watanabe, K.;Takasawa, K.;Nakanuma, Y. Virchows Arch 441巻 1号 98-100頁 2002
  • Autoimmune cholangitis in the SJL/J mouse is antigen non-specific M. A. Sasaki, J.;Odin, J. A.;Thung, S. N.;Coppel, R.;Nakanuma, Y.;Gershwin, M. E. Dev Immunol 9巻 2号 103-11頁 2002
  • Primary squamous cell carcinoma of the liver producing parathyroid hormone-related protein T. H. Saito, K.;Tsuneyama, K.;Hirano, M.;Amaya, S.;Sasaki, M.;Kaneko, S.;Kobayashi, K.;Nakanuma, Y. J Gastroenterol 37巻 2号 138-42頁 2002
  • Biliary papillary neoplasm of the liver Y. S. Nakanuma, M.;Ishikawa, A.;Tsui, W.;Chen, T. C.;Huang, S. F. Histol Histopathol 17巻 3号 851-61頁 2002
  • Immunoglobulin gene usage and immunohistochemical characteristics of human monoclonal antibodies to the mitochondrial autoantigens of primary biliary cirrhosis induced in the XenoMouse M. V. D. W. Sasaki, J.;Kenny, T. P.;Gallo, M. L.;Leung, P. S.;Nakanuma, Y.;Ansari, A. A.;Coppel, R. L.;Neuberger, J.;Gershwin, M. E. Hepatology 34巻 4 Pt 1号 631-7頁 2001
  • Intrahepatic cholangitis and arteritis after transcatheter arterial embolization in a patient with tumor-like lesion-associated autoimmune hepatitis M. S. Iwata, M.;Harada, K.;Kaneko, S.;Kobayashi, K.;Adachi, K.;Sasaki, M.;Nakanuma, Y. Pathol Res Pract 197巻 1号 59-63頁 2001
  • Precancerous lesions of intrahepatic cholangiocarcinoma T. S. Shimonishi, M.;Nakanuma, Y. J Hepatobiliary Pancreat Surg 7巻 6号 542-50頁 2000
  • Comparative immunoreactivity of anti-trifluoroacetyl (TFA) antibody and anti-lipoic acid antibody in primary biliary cirrhosis: searching for a mimic M. A. Sasaki, A.;Pumford, N.;van de Water, J.;Leung, P. S.;Humphries, K. M.;Szweda, L. I.;Nakanuma, Y.;Roche, T. E.;Coppel, R. L.;Bach, J. F.;Gershwin, M. E. J Autoimmun 15巻 1号 51-60頁 2000
  • Definition and pathology of primary sclerosing cholangitis Y. H. Nakanuma, K.;Katayanagi, K.;Tsuneyama, K.;Sasaki, M. J Hepatobiliary Pancreat Surg 6巻 4号 333-42頁 1999
  • Increased MUC6 apomucin expression is a characteristic of reactive biliary epithelium in chronic viral hepatitis M. N. Sasaki, Y.;Ho, S. B.;Kim, Y. S. J Pathol 185巻 2号 191-8頁 1998
  • Cholangiocarcinomas arising in cirrhosis and combined hepatocellular-cholangiocellular carcinomas share apomucin profiles M. N. Sasaki, Y.;Ho, S. B.;Kim, Y. S. Am J Clin Pathol 109巻 3号 302-8頁 1998
  • Expression of apomucins in the intrahepatic biliary tree in hepatolithiasis differs from that in normal liver and extrahepatic biliary obstruction M. N. Sasaki, Y.;Kim, Y. S. Hepatology 27巻 1号 54-61頁 1998
  • Microstructure and development of the normal and pathologic biliary tract in humans, including blood supply Y. H. Nakanuma, M.;Sanzen, T.;Sasaki, M. Microsc Res Tech 38巻 6号 552-70頁 1997
  • Abnormal expression of MUC1 apomucin and mature MUC1 mucin in biliary epithelial cells in various cystic liver diseases M. N. Sasaki, Y. Hepatology 24巻 3号 539-43頁 1996
  • Are bile duct lesions of primary biliary cirrhosis distinguishable from those of autoimmune hepatitis and chronic viral hepatitis? Interobserver histological agreement on trimmed bile ducts Y. H. Zen, K.;Sasaki, M.;Tsuneyama, K.;Matsui, K.;Haratake, J.;Sakisaka, S.;Maeyama, S.;Yamamoto, K.;Nakano, M.;Shimamatsu, K.;Kage, M.;Kurose, N.;Uchiyama, A.;Kaizaki, Y.;Toda, G.;Nakanuma, Y. J Gastroenterol 40巻 2号 164-70頁 2005
  • Proposal of histological criteria for intraepithelial atypical/proliferative biliary epithelial lesions of the bile duct in hepatolithiasis with respect to cholangiocarcinoma: preliminary report based on interobserver agreement Y. A. Zen, S.;Ajioka, Y.;Haratake, J.;Kage, M.;Kondo, F.;Nimura, Y.;Sakamoto, M.;Sasaki, M.;Shimamatsu, K.;Wakasa, K.;Park, Y. N.;Chen, M. F.;Atomi, Y.;Nakanuma, Y. Pathol Int 55巻 4号 180-8頁 2005
  • Frequent cellular senescence in small bile ducts in primary biliary cirrhosis: a possible role in bile duct loss M. I. Sasaki, H.;Haga, H.;Manabe, T.;Nakanuma, Y. J Pathol 205巻 4号 451-9頁 2005
  • Abundant IgG4-positive plasma cell infiltration characterizes chronic sclerosing sialadenitis (Kuttner's tumor) S. Z. Kitagawa, Y.;Harada, K.;Sasaki, M.;Sato, Y.;Minato, H.;Watanabe, K.;Kurumaya, H.;Katayanagi, K.;Masuda, S.;Niwa, H.;Tsuneyama, K.;Saito, K.;Haratake, J.;Takagawa, K.;Nakanuma, Y. Am J Surg Pathol 29巻 6号 783-91頁 2005
  • IgG4-related sclerosing cholangitis with and without hepatic inflammatory pseudotumor, and sclerosing pancreatitis-associated sclerosing cholangitis: do they belong to a spectrum of sclerosing pancreatitis? Y. H. Zen, K.;Sasaki, M.;Sato, Y.;Tsuneyama, K.;Haratake, J.;Kurumaya, H.;Katayanagi, K.;Masuda, S.;Niwa, H.;Morimoto, H.;Miwa, A.;Uchiyama, A.;Portmann, B. C.;Nakanuma, Y. Am J Surg Pathol 28巻 9号 1193-203頁 2004
  • Frequent p16ink4a inactivation is an early and frequent event of intraductal papillary neoplasm of the liver arising in hepatolithiasis A. S. Ishikawa, M.;Sato, Y.;Ohira, S.;Chen, M. F.;Huang, S. F.;Oda, K.;Nimura, Y.;Nakanuma, Y. Hum Pathol 35巻 12号 1505-14頁 2004
  • Combined hepatocellular and cholangiocarcinoma with marked squamous cell carcinoma components arising in non-cirrhotic liver K. K. Tsuneyama, Y.;Doden, K.;Kidani, E.;Harada, K.;Sasaki, M.;Nakanuma, Y. Pathol Int 53巻 2号 33055頁 2003
  • Intrahepatic cholangiocarcinoma in cirrhosis presents granulocyte and granulocyte-macrophage colony-stimulating factor M. T. Sasaki, K.;Ishikawa, A.;Nakanuma, Y. Hum Pathol 34巻 12号 1337-44頁 2003
  • Aberrant expression of trefoil factor family 1 in biliary epithelium in hepatolithiasis and cholangiocarcinoma M. T. Sasaki, K.;Nakanuma, Y. Lab Invest 83巻 10号 1403-13頁 2003
  • Decrease of deleted in malignant brain tumour-1 (DMBT-1) expression is a crucial late event in intrahepatic cholangiocarcinoma M. H. Sasaki, S. F.;Chen, M. F.;Jan, Y. Y.;Yeh, T. S.;Ishikawa, A.;Mollenhauer, J.;Poustka, A.;Tsuneyama, K.;Nimura, Y.;Oda, K.;Nakanuma, Y. Histopathology 43巻 4号 340-6頁 2003
  • Expression of deleted in malignant brain tumor-1 (DMBT1) molecule in biliary epithelium is augmented in hepatolithiasis: possible participation in lithogenesis M. H. Sasaki, S. F.;Chen, M. F.;Jan, Y. Y.;Yeh, T. S.;Ishikawa, A.;Mollenhauer, J.;Poustka, A.;Tsuneyama, K.;Nimura, Y.;Oda, K.;Nakanuma, Y. Dig Dis Sci 48巻 7号 1234-40頁 2003
  • Anatomic and molecular pathology of intrahepatic cholangiocarcinoma Y. H. Nakanuma, K.;Ishikawa, A.;Zen, Y.;Sasaki, M. J Hepatobiliary Pancreat Surg 10巻 4号 265-81頁 2003
  • Expression of MUC1 and MUC2 mucin core proteins and their messenger RNA in gall bladder carcinoma: an immunohistochemical and in situ hybridization study T. S. Yamato, M.;Watanabe, Y.;Nakanuma, Y. J Pathol 188巻 1号 42946頁 1999
  • Frequent expression of mucin core protein MUC1 in non-neoplastic gallbladder mucosa from patients with pancreaticobiliary maljunction T. K. Yamato, H.;Ohama, K.;Yamamichi, N.;Watanabe, Y.;Harada, K.;Sasaki, M.;Nakanuma, Y. Liver 19巻 4号 281-7頁 1999
  • A case report of gastric carcinosarcoma with rhabdomyosarcomatous and neuroendocrinal differentiation K. S. Tsuneyama, M.;Sabit, A.;Yokoi, K.;Arano, Y.;Imai, T.;Nakanuma, Y. Pathol Res Pract 195巻 2号 93-7; discussion 98頁 1999
  • Lipopolysaccharide induces overexpression of MUC2 and MUC5AC in cultured biliary epithelial cells: possible key phenomenon of hepatolithiasis Y. H. Zen, K.;Sasaki, M.;Tsuneyama, K.;Katayanagi, K.;Yamamoto, Y.;Nakanuma, Y. Am J Pathol 161巻 4号 1475-84頁 2002
  • Damaged interlobular bile ducts in primary biliary cirrhosis show reduced expression of glutathione-S-transferase-pi and aberrant expression of 4-hydroxynonenal K. H. Tsuneyama, K.;Kono, N.;Sasaki, M.;Saito, T.;Gershwin, M. E.;Ikemoto, M.;Arai, H.;Nakanuma, Y. J Hepatol 37巻 2号 176-83頁 2002
  • The SJL/J mouse is not a model for PBC M. L. Sasaki, S. A.;Van De Water, J.;He, X. S.;Shultz, L.;Coppel, R. L.;Ansari, A.;Nakanuma, Y.;Gershwin, M. E. Hepatology 35巻 5号 1284-6頁 2002
  • The immunopathology of primary biliary cirrhosis: thoughts for the millennium M. A. Sasaki, A. A.;Nakanuma, Y.;Coppel, R. L.;Keeffe, E. B.;Gershwin, M. E. Arch Immunol Ther Exp (Warsz) 48巻 1号 42745頁 2000
  • Evidence of the participation of peribiliary mast cells in regulation of the peribiliary vascular plexus along the intrahepatic biliary tree W. H. Koda, K.;Tsuneyama, K.;Kono, N.;Sasaki, M.;Matsui, O.;Nakanuma, Y. Lab Invest 80巻 7号 1007-17頁 2000
  • Amplification and sequence analysis of partial bacterial 16S ribosomal RNA gene in gallbladder bile from patients with primary biliary cirrhosis K. H. Hiramatsu, K.;Tsuneyama, K.;Sasaki, M.;Fujita, S.;Hashimoto, T.;Kaneko, S.;Kobayashi, K.;Nakanuma, Y. J Hepatol 33巻 1号 42996頁 2000
  • Aberrant expression of stem cell factor on biliary epithelial cells and peribiliary infiltration of c-kit-expressing mast cells in hepatolithiasis and primary sclerosing cholangitis: a possible contribution to bile duct fibrosis K. K. Tsuneyama, N.;Yamashiro, M.;Kouda, W.;Sabit, A.;Sasaki, M.;Nakanuma, Y. J Pathol 189巻 4号 609-14頁 1999
  • Expression of sialyl-Tn, Tn and T antigens in primary liver cancer M. Y. Sasaki, T.;Nakanuma, Y. Pathol Int 49巻 4号 325-31頁 1999
  • Expression of MUC2, MUC5AC and MUC6 apomucins in carcinoma, dysplasia and non-dysplastic epithelia of the gallbladder M. Y. Sasaki, T.;Nakanuma, Y.;Ho, S. B.;Kim, Y. S. Pathol Int 49巻 1号 38-44頁 1999
  • Frequent expression of MUC1 apomucin on biliary epithelial cells of damaged small bile ducts in primary biliary cirrhosis and chronic viral hepatitis: an immunohistochemical study M. N. Sasaki, Y. Hepatology 23巻 6号 1313-7頁 1996
  • Characterization of apomucin expression in intrahepatic cholangiocarcinomas and their precursor lesions: an immunohistochemical study M. N. Sasaki, Y.;Kim, Y. S. Hepatology 24巻 5号 1074-8頁 1996
  • Carcinoembryonic antigen and blood group-related carbohydrate antigens in glycoproteins in human bile in hepatolithiasis. Japanese Study Group of Hepatolithiasis M. M. Sasaki, T.;Hoso, M.;Nakanuma, Y.;Tanimura, H. Hepatology 23巻 2号 258-63頁 1996
  • S1P3-mediated cardiac fibrosis in sphingosine kinase 1 transgenic mice involves reactive oxygen species N. O. Takuwa, S.;Takashima, S.;Ohtani, K.;Okamoto, Y.;Tanaka, T.;Hirano, K.;Usui, S.;Wang, F.;Du, W.;Yoshioka, K.;Banno, Y.;Sasaki, M.;Ichi, I.;Okamura, M.;Sugimoto, N.;Mizugishi, K.;Nakanuma, Y.;Ishii, I.;Takamura, M.;Kaneko, S.;Kojo, S.;Satouchi, K.;Mitumori, K.;Chun, J.;Takuwa, Y. Cardiovasc Res 85巻 3号 484-93頁 2010
  • Intraductal tubular neoplasm of the common bile duct Y. O. Sato, H.;Harada, K.;Sasaki, M.;Nakanuma, Y. Pathol Int 60巻 7号 516-9頁 2010
  • Epithelial-mesenchymal transition induced by transforming growth factor-{beta}1/Snail activation aggravates invasive growth of cholangiocarcinoma Y. H. Sato, K.;Itatsu, K.;Ikeda, H.;Kakuda, Y.;Shimomura, S.;Shan Ren, X.;Yoneda, N.;Sasaki, M.;Nakanuma, Y. Am J Pathol 177巻 1号 141-52頁 2010
  • Biliary epithelial apoptosis, autophagy, and senescence in primary biliary cirrhosis M. N. Sasaki, Y. Hepat Res Treat 2010巻 205128頁 2010
  • Modulation of the microenvironment by senescent biliary epithelial cells may be involved in the pathogenesis of primary biliary cirrhosis M. M. Sasaki, M.;Sato, Y.;Nakanuma, Y. J Hepatol 53巻 2号 318-25頁 2010
  • Autophagy mediates the process of cellular senescence characterizing bile duct damages in primary biliary cirrhosis M. M. Sasaki, M.;Sato, Y.;Nakanuma, Y. Lab Invest 90巻 6号 835-43頁 2010
  • Primary localized malignant biphasic mesothelioma of the liver in a patient with asbestosis M. A. Sasaki, I.;Yasui, T.;Kinoshita, M.;Itatsu, K.;Nojima, T.;Nakanuma, Y. World J Gastroenterol 15巻 5号 615-21頁 2009
  • Multistep carcinogenesis of perihilar cholangiocarcinoma arising in the intrahepatic large bile ducts Y. S. Nakanuma, M.;Sato, Y.;Ren, X.;Ikeda, H.;Harada, K. World J Hepatol 1巻 1号 35-42頁 2009
  • Endothelial to mesenchymal transition via transforming growth factor-beta1/Smad activation is associated with portal venous stenosis in idiopathic portal hypertension A. S. Kitao, Y.;Sawada-Kitamura, S.;Harada, K.;Sasaki, M.;Morikawa, H.;Shiomi, S.;Honda, M.;Matsui, O.;Nakanuma, Y. Am J Pathol 175巻 2号 616-26頁 2009
  • Phosphorylation of extracellular signal-regulated kinase 1/2, p38 mitogen-activated protein kinase and nuclear translocation of nuclear factor-kappaB are involved in upregulation of matrix metalloproteinase-9 by tumour necrosis factor-alpha K. S. Itatsu, M.;Harada, K.;Yamaguchi, J.;Ikeda, H.;Sato, Y.;Ohta, T.;Sato, H.;Nagino, M.;Nimura, Y.;Nakanuma, Y. Liver Int 29巻 2号 291-8頁 2009
  • Cyclooxygenase-2 is involved in the up-regulation of matrix metalloproteinase-9 in cholangiocarcinoma induced by tumor necrosis factor-alpha K. S. Itatsu, M.;Yamaguchi, J.;Ohira, S.;Ishikawa, A.;Ikeda, H.;Sato, Y.;Harada, K.;Zen, Y.;Sato, H.;Ohta, T.;Nagino, M.;Nimura, Y.;Nakanuma, Y. Am J Pathol 174巻 3号 829-41頁 2009
  • Large cell change of hepatocytes in chronic viral hepatitis represents a senescent-related lesion H. S. Ikeda, M.;Sato, Y.;Harada, K.;Zen, Y.;Mitsui, T.;Nakanuma, Y. Hum Pathol 40巻 12号 1774-82頁 2009
  • Bile ductular cell reaction with senescent hepatocytes in chronic viral hepatitis is lost during hepatocarcinogenesis H. S. Ikeda, M.;Sato, Y.;Harada, K.;Zen, Y.;Mitsui, T.;Nakanuma, Y. Pathol Int 59巻 7号 471-8頁 2009
  • Over-expression of polycomb group protein EZH2 relates to decreased expression of p16 INK4a in cholangiocarcinogenesis in hepatolithiasis M. Y. Sasaki, J.;Itatsu, K.;Ikeda, H.;Nakanuma, Y. J Pathol 215巻 2号 175-83頁 2008
  • The overexpression of polycomb group proteins Bmi1 and EZH2 is associated with the progression and aggressive biological behavior of hepatocellular carcinoma M. I. Sasaki, H.;Itatsu, K.;Yamaguchi, J.;Sawada, S.;Minato, H.;Ohta, T.;Nakanuma, Y. Lab Invest 88巻 8号 873-82頁 2008
  • Activation of ATM signaling pathway is involved in oxidative stress-induced expression of mito-inhibitory p21WAF1/Cip1 in chronic non-suppurative destructive cholangitis in primary biliary cirrhosis: an immunohistochemical study M. I. Sasaki, H.;Nakanuma, Y. J Autoimmun 31巻 1号 26877頁 2008
  • Significance of enhanced expression of nitric oxide syntheses in splenic sinus lining cells in altered portal hemodynamics of idiopathic portal hypertension Y. S. Sato, S.;Kozaka, K.;Harada, K.;Sasaki, M.;Matsui, O.;Nakanuma, Y. Dig Dis Sci 52巻 8号 1987-94頁 2007
  • Cholangiocytes with mesenchymal features contribute to progressive hepatic fibrosis of the polycystic kidney rat Y. H. Sato, K.;Ozaki, S.;Furubo, S.;Kizawa, K.;Sanzen, T.;Yasoshima, M.;Ikeda, H.;Sasaki, M.;Nakanuma, Y. Am J Pathol 171巻 6号 1859-71頁 2007
  • Biliary infection may exacerbate biliary cystogenesis through the induction of VEGF in cholangiocytes of the polycystic kidney (PCK) rat X. S. S. Ren, Y.;Harada, K.;Sasaki, M.;Yoneda, N.;Lin, Z. H.;Nakanuma, Y. Am J Pathol 179巻 6号 2845-54頁 2011
  • Characterization of hepatocellular adenoma based on the phenotypic classification: The Kanazawa experience M. Y. Sasaki, N.;Kitamura, S.;Sato, Y.;Nakanuma, Y. Hepatol Res 41巻 10号 982-8頁 2011
  • Intrahepatic cholangiocarcinoma arising in chronic advanced liver disease and the cholangiocarcinomatous component of hepatocellular cholangiocarcinoma share common phenotypes and cholangiocarcinogenesis J. S. Xu, M.;Harada, K.;Sato, Y.;Ikeda, H.;Kim, J. H.;Yu, E.;Nakanuma, Y. Histopathology 59巻 6号 1090-9頁 2011
  • Epidermal growth factor induces cytokeratin 19 expression accompanied by increased growth abilities in human hepatocellular carcinoma N. S. Yoneda, Y.;Kitao, A.;Ikeda, H.;Sawada-Kitamura, S.;Miyakoshi, M.;Harada, K.;Sasaki, M.;Matsui, O.;Nakanuma, Y. Lab Invest 91巻 2号 262-72頁 2011
  • Bile duct expression of pancreatic and duodenal homeobox 1 in perihilar cholangiocarcinogenesis S. M. Igarashi, T.;Harada, K.;Ikeda, H.;Sato, Y.;Sasaki, M.;Matsui, O.;Nakanuma, Y. Histopathology 61巻 2号 266-76頁 2012
  • Overview of hepatocellular adenoma in Japan M. N. Sasaki, Y. Int J Hepatol 2012巻 648131頁 2012
  • Papillary hyperplasia of the gallbladder in pancreaticobiliary maljunction represents a senescence-related lesion induced by lysolecithin J. S. Yamaguchi, M.;Harada, K.;Zen, Y.;Sato, Y.;Ikeda, H.;Itatsu, K.;Yokoyama, Y.;Ando, H.;Ohta, T.;Kubota, A.;Shimizu, K.;Nimura, Y.;Nagino, M.;Nakanuma, Y. Lab Invest 89巻 9号 1018-31頁 2009
  • Inhibition of intrahepatic bile duct dilation of the polycystic kidney rat with a novel tyrosine kinase inhibitor gefitinib Y. H. Sato, K.;Furubo, S.;Kizawa, K.;Sanzen, T.;Yasoshima, M.;Ozaki, S.;Isse, K.;Sasaki, M.;Nakanuma, Y. Am J Pathol 169巻 4号 1238-50頁 2006
  • Different expression patterns of mucin core proteins and cytokeratins during intrahepatic cholangiocarcinogenesis from biliary intraepithelial neoplasia and intraductal papillary neoplasm of the bile duct--an immunohistochemical study of 110 cases of hepatolithiasis Y. S. Zen, M.;Fujii, T.;Chen, T. C.;Chen, M. F.;Yeh, T. S.;Jan, Y. Y.;Huang, S. F.;Nimura, Y.;Nakanuma, Y. J Hepatol 44巻 2号 350-8頁 2006
  • Interaction of Toll-like receptors with bacterial components induces expression of CDX2 and MUC2 in rat biliary epithelium in vivo and in culture H. S. Ikeda, M.;Ishikawa, A.;Sato, Y.;Harada, K.;Zen, Y.;Kazumori, H.;Nakanuma, Y. Lab Invest 87巻 6号 559-71頁 2007
  • Local balance of transforming growth factor-beta1 secreted from cholangiocarcinoma cells and stromal-derived factor-1 secreted from stromal fibroblasts is a factor involved in invasion of cholangiocarcinoma S. I. Ohira, K.;Sasaki, M.;Harada, K.;Sato, Y.;Zen, Y.;Ishikawa, A.;Oda, K.;Nagasaka, T.;Nimura, Y.;Nakanuma, Y. Pathol Int 56巻 7号 381-9頁 2006
  • Polycomb group protein Bmi1 is overexpressed and essential in anchorage-independent colony formation, cell proliferation and repression of cellular senescence in cholangiocarcinoma: tissue and culture studies M. Y. Sasaki, J.;Ikeda, H.;Itatsu, K.;Nakanuma, Y. Hum Pathol 40巻 12号 1723-30頁 2009
  • Hepatic stellate cells are activated around central scars of focal nodular hyperplasia of the liver--a potential mechanism of central scar formation Y. H. Sato, K.;Ikeda, H.;Fijii, T.;Sasaki, M.;Zen, Y.;Nakanuma, Y. Hum Pathol 40巻 2号 181-8頁 2009
  • Involvement of Escherichia coli in pathogenesis of xanthogranulomatous cholecystitis with scavenger receptor class A and CXCL16-CXCR6 interaction S. H. Sawada, K.;Isse, K.;Sato, Y.;Sasaki, M.;Kaizaki, Y.;Nakanuma, Y. Pathol Int 57巻 10号 652-63頁 2007
  • Regulation of adiponectin receptor expression in human liver and a hepatocyte cell line A. T. Shimizu, T.;Matsuzawa, N.;Nakamura, S.;Nabemoto, S.;Takeshita, Y.;Misu, H.;Kurita, S.;Sakurai, M.;Yokoyama, M.;Zen, Y.;Sasaki, M.;Nakanuma, Y.;Kaneko, S. Metabolism 56巻 11号 1478-85頁 2007
  • Histological course of nonalcoholic fatty liver disease in Japanese patients: tight glycemic control, rather than weight reduction, ameliorates liver fibrosis E. T. Hamaguchi, T.;Sakurai, M.;Mizukoshi, E.;Zen, Y.;Takeshita, Y.;Kurita, S.;Arai, K.;Yamashita, T.;Sasaki, M.;Nakanuma, Y.;Kaneko, S. Diabetes Care 33巻 2号 284-6頁 2010
  • Proinflammatory cytokine-induced cellular senescence of biliary epithelial cells is mediated via oxidative stress and activation of ATM pathway: a culture study M. I. Sasaki, H.;Sato, Y.;Nakanuma, Y. Free Radic Res 42巻 7号 625-32頁 2008
  • Tumorigenesis and phenotypic characteristics of mucin-producing bile duct tumors: an immunohistochemical approach Y. Z. Nakanuma, Y.;Harada, K.;Ikeda, H.;Sato, Y.;Uehara, T.;Sasaki, M. J Hepatobiliary Pancreat Sci 17巻 3号 211-22頁 2010
  • Pathological classification of intrahepatic cholangiocarcinoma based on a new concept Y. S. Nakanuma, Y.;Harada, K.;Sasaki, M.;Xu, J.;Ikeda, H. World J Hepatol 2巻 12号 419-27頁 2010
  • alpha-Fetoprotein-producing gastric carcinoma and combined hepatocellular and cholangiocarcinoma show similar morphology but different histogenesis with respect to SALL4 expression H. S. Ikeda, Y.;Yoneda, N.;Harada, K.;Sasaki, M.;Kitamura, S.;Sudo, Y.;Ooi, A.;Nakanuma, Y. Hum Pathol 43巻 11号 1955-63頁 2012
  • Application of a new histological staging and grading system for primary biliary cirrhosis to liver biopsy specimens: Interobserver agreement Y. Z. Nakanuma, Y.;Harada, K.;Sasaki, M.;Nonomura, A.;Uehara, T.;Sano, K.;Kondo, F.;Fukusato, T.;Tsuneyama, K.;Ito, M.;Wakasa, K.;Nomoto, M.;Minato, H.;Haga, H.;Kage, M.;Yano, H.;Haratake, J.;Aishima, S.;Masuda, T.;Aoyama, H.;Miyakawa-Hayashino, A.;Matsumoto, T.;Sanefuji, H.;Ojima, H.;Chen, T. C.;Yu, E.;Kim, J. H.;Park, Y. N.;Tsui, W. Pathol Int 60巻 3号 167-74頁 2010
  • Immunohistochemical characteristics and malignant progression of hepatic cystic neoplasms in comparison with pancreatic counterparts T. S. Matsubara, Y.;Sasaki, M.;Harada, K.;Nomoto, K.;Tsuneyama, K.;Nakamura, K.;Gabata, T.;Matsui, O.;Nakanuma, Y. Hum Pathol 43巻 12号 2177-86頁 2012
  • Decreased expression of Bmi1 is closely associated with cellular senescence in small bile ducts in primary biliary cirrhosis M. I. Sasaki, H.;Sato, Y.;Nakanuma, Y. Am J Pathol 169巻 3号 831-45頁 2006
  • GI24 enhances tumor invasiveness by regulating cell surface membrane-type 1 matrix metalloproteinase M. A. T. Sakr, T.;Domoto, T.;Nakano, H.;Wong, R. W.;Sasaki, M.;Nakanuma, Y.;Sato, H. Cancer Sci 101巻 11号 2368-74頁 2010
  • Bile ductular cells undergoing cellular senescence increase in chronic liver diseases along with fibrous progression M. I. Sasaki, H.;Yamaguchi, J.;Miyakoshi, M.;Sato, Y.;Nakanuma, Y. Am J Clin Pathol 133巻 2号 212-23頁 2010
  • Autophagy may precede cellular senescence of bile ductular cells in ductular reaction in primary biliary cirrhosis M. M. Sasaki, M.;Sato, Y.;Nakanuma, Y. Dig Dis Sci 57巻 3号 660-6頁 2012
  • A possible involvement of p62/sequestosome-1 in the process of biliary epithelial autophagy and senescence in primary biliary cirrhosis M. M. Sasaki, M.;Sato, Y.;Nakanuma, Y. Liver Int 32巻 3号 487-99頁 2012
  • Participation of peribiliary glands in biliary tract pathophysiologies S. S. Igarashi, Y.;Ren, X. S.;Harada, K.;Sasaki, M.;Nakanuma, Y. World J Hepatol 5巻 8号 425-32頁 2013
  • Clinicopathologic significance of combined hepatocellular-cholangiocarcinoma with stem cell subtype components with reference to the expression of putative stem cell markers H. H. Ikeda, K.;Sato, Y.;Sasaki, M.;Yoneda, N.;Kitamura, S.;Sudo, Y.;Ooi, A.;Nakanuma, Y. Am J Clin Pathol 140巻 3号 329-40頁 2013
  • Intraductal papillary cholangiocarcinoma and atypical biliary epithelial lesions confused with intrabiliary extension of metastatic colorectal carcinoma K. F. Itatsu, T.;Sasaki, M.;Zen, Y.;Nakanuma, Y. Hepatogastroenterology 54巻 75号 677-80頁 2007
  • Immunohistochemical analysis of the progression of flat and papillary preneoplastic lesions in intrahepatic cholangiocarcinogenesis in hepatolithiasis K. Z. Itatsu, Y.;Ohira, S.;Ishikawa, A.;Sato, Y.;Harada, K.;Ikeda, H.;Sasaki, M.;Nimura, Y.;Nakanuma, Y. Liver Int 27巻 9号 1174-84頁 2007
  • A subgroup of intrahepatic cholangiocarcinoma with an infiltrating replacement growth pattern and a resemblance to reactive proliferating bile ductules: 'bile ductular carcinoma' K. S. Kozaka, M.;Fujii, T.;Harada, K.;Zen, Y.;Sato, Y.;Sawada, S.;Minato, H.;Matsui, O.;Nakanuma, Y. Histopathology 51巻 3号 390-400頁 2007
  • Intraductal papillary-mucinous neoplasm of the pancreas associated with polycystic liver and kidney disease Y. M. Sato, M.;Sasaki, M.;Kitao, A.;Yoneda, N.;Kobayashi, D.;Imamura, Y.;Nakanuma, Y. Pathol Int 59巻 3号 201-4頁 2009
  • Augmented expression of hepatocytes growth factor activator inhibitor type 1 (HAI-1) in intrahepatic small bile ducts in primary biliary cirrhosis M. I. Sasaki, H.;Kataoka, H.;Nakanuma, Y. Virchows Arch 449巻 4号 462-71頁 2006
  • Clinicopathological significance of antinuclear antibodies in non-alcoholic steatohepatitis H. S. Niwa, M.;Haratake, J.;Kasai, T.;Katayanagi, K.;Kurumaya, H.;Masuda, S.;Minato, H.;Zen, Y.;Uchiyama, A.;Miwa, A.;Saito, K.;Sudo, Y.;Nakanuma, Y. Hepatol Res 37巻 11号 923-31頁 2007
  • Liver steatosis, but not fibrosis, is associated with insulin resistance in nonalcoholic fatty liver disease M. T. Sakurai, T.;Ota, T.;Ando, H.;Akahori, H.;Kaji, K.;Sasaki, M.;Nakanuma, Y.;Miura, K.;Kaneko, S. J Gastroenterol 42巻 4号 312-7頁 2007
  • Flare-up of nonalcoholic steatohepatitis after hepatectomy resulted in hepatic failure in a patient with type 2 diabetes mellitus M. I. Sasaki, K.;Minato, H.;Takamura, H.;Ohta, T.;Nakanuma, Y. Dig Dis Sci 52巻 12号 574680頁 2007
  • Naturally-occurring regulatory T cells are increased in inflamed portal tracts with cholangiopathy in primary biliary cirrhosis M. I. Sasaki, H.;Sawada, S.;Sato, Y.;Nakanuma, Y. J Clin Pathol 60巻 10号 1102-7頁 2007
  • Possible regulation of migration of intrahepatic cholangiocarcinoma cells by interaction of CXCR4 expressed in carcinoma cells with tumor necrosis factor-alpha and stromal-derived factor-1 released in stroma S. S. Ohira, M.;Harada, K.;Sato, Y.;Zen, Y.;Isse, K.;Kozaka, K.;Ishikawa, A.;Oda, K.;Nimura, Y.;Nakanuma, Y. Am J Pathol 168巻 4号 1155-68頁 2006
  • Expression profiles of MUC mucins and trefoil factor family (TFF) peptides in the intrahepatic biliary system: physiological distribution and pathological significance M. I. Sasaki, H.;Nakanuma, Y. Prog Histochem Cytochem 42巻 2号 61-110頁 2007
  • Hepatocellular carcinoma arising in primary biliary cirrhosis presenting with nodular regenerative hyperplasia: report of an autopsy case M. H. Sasaki, Y.;Nakanuma, Y. J Gastroenterol Hepatol 21巻 12号 1866-8頁 2006
  • Serum amyloid A-positive hepatocellular neoplasms in the resected livers from 3 patients with alcoholic cirrhosis M. K. Sasaki, F.;Sawai, Y.;Imai, Y.;Kadowaki, S.;Sano, K.;Fukusato, T.;Matsui, O.;Nakanuma, Y. Histol Histopathol 28巻 11号 1499-505頁 2013
  • Evaluation of a new histologic staging and grading system for primary biliary cirrhosis in comparison with classical systems Y. H. Kakuda, K.;Sawada-Kitamura, S.;Ikeda, H.;Sato, Y.;Sasaki, M.;Okafuji, H.;Mizukoshi, E.;Terasaki, S.;Ohta, H.;Kasashima, S.;Kawashima, A.;Kaizaki, Y.;Kaneko, S.;Nakanuma, Y. Hum Pathol 44巻 6号 1107-17頁 2013
  • KRAS and GNAS mutations and p53 overexpression in biliary intraepithelial neoplasia and intrahepatic cholangiocarcinomas M. S. Hsu, M.;Igarashi, S.;Sato, Y.;Nakanuma, Y. Cancer 119巻 9号 1669-74頁 2013
  • Association of interleukin-28B genotype and hepatocellular carcinoma recurrence in patients with chronic hepatitis C Y. H. Hodo, M.;Tanaka, A.;Nomura, Y.;Arai, K.;Yamashita, T.;Sakai, Y.;Yamashita, T.;Mizukoshi, E.;Sakai, A.;Sasaki, M.;Nakanuma, Y.;Moriyama, M.;Kaneko, S. Clin Cancer Res 19巻 7号 1827-37頁 2013
  • Hilar cholangiocarcinoma and pancreatic ductal adenocarcinoma share similar histopathologies, immunophenotypes, and development-related molecules C. H. Gandou, K.;Sato, Y.;Igarashi, S.;Sasaki, M.;Ikeda, H.;Nakanuma, Y. Hum Pathol 44巻 5号 811-21頁 2013
  • Beta-catenin-activated hepatocellular adenoma showing hyperintensity on hepatobiliary-phase gadoxetic-enhanced magnetic resonance imaging and overexpression of OATP8 N. M. Yoneda, O.;Kitao, A.;Kozaka, K.;Gabata, T.;Sasaki, M.;Nakanuma, Y.;Murata, K.;Tani, T. Jpn J Radiol 30巻 9号 777-82頁 2012
  • Intrahepatic cholangiocarcinomas in cirrhosis are hypervascular in comparison with those in normal livers J. I. Xu, S.;Sasaki, M.;Matsubara, T.;Yoneda, N.;Kozaka, K.;Ikeda, H.;Kim, J.;Yu, E.;Matsui, O.;Nakanuma, Y. Liver Int 32巻 7号 1156-64頁 2012
  • Induction of elastin expression in vascular endothelial cells relates to hepatoportal sclerosis in idiopathic portal hypertension: possible link to serum anti-endothelial cell antibodies Y. R. Sato, X. S.;Harada, K.;Sasaki, M.;Morikawa, H.;Shiomi, S.;Honda, M.;Kaneko, S.;Nakanuma, Y. Clin Exp Immunol 167巻 3号 532-42頁 2012
  • Heat shock proteins 27 and 70 are potential biliary markers for the detection of cholangiocarcinoma Y. H. Sato, K.;Sasaki, M.;Yasaka, T.;Nakanuma, Y. Am J Pathol 180巻 1号 123-30頁 2012
  • A serum amyloid A-positive hepatocellular neoplasm arising in alcoholic cirrhosis: a previously unrecognized type of inflammatory hepatocellular tumor M. Y. Sasaki, N.;Kitamura, S.;Sato, Y.;Nakanuma, Y. Mod Pathol 25巻 12号 1584-93頁 2012
  • Novel approach to bile duct damage in primary biliary cirrhosis: participation of cellular senescence and autophagy M. N. Sasaki, Y. Int J Hepatol 2012巻 452143頁 2012
  • Pathological spectrum of intrahepatic cholangiocarcinoma arising in non-biliary chronic advanced liver diseases Y. X. Nakanuma, J.;Harada, K.;Sato, Y.;Sasaki, M.;Ikeda, H.;Kim, J.;Yu, E. Pathol Int 61巻 5号 298-305頁 2011
  • A Case of Hypereosinophilia-Associated Multiple Mass Lesions of Liver Showing Non-Granulomatous Eosinophilic Hepatic Necrosis H. K. Ikeda, K.;Kurumaya, H.;Harada, K.;Sato, Y.;Sasaki, M.;Nakanuma, Y. Gastroenterology Res 4巻 4号 168-173頁 2011
  • Participation of bile ductular cells in the pathological progression of non-alcoholic fatty liver disease M. S. Chiba, M.;Kitamura, S.;Ikeda, H.;Sato, Y.;Nakanuma, Y. J Clin Pathol 64巻 7号 564-70頁 2011
  • Histone deacetylase inhibitor (SAHA) and repression of EZH2 synergistically inhibit proliferation of gallbladder carcinoma J. S. Yamaguchi, M.;Sato, Y.;Itatsu, K.;Harada, K.;Zen, Y.;Ikeda, H.;Nimura, Y.;Nagino, M.;Nakanuma, Y. Cancer Sci 101巻 2号 355-62頁 2010
  • Autophagy may promote carcinoma cell invasion and correlate with poor prognosis in cholangiocarcinoma T. S. Nitta, Y.;Ren, X. S.;Harada, K.;Sasaki, M.;Hirano, S.;Nakanuma, Y. Int J Clin Exp Pathol 7巻 8号 4913-21頁 2014
  • Serum amyloid A-positive hepatocellular neoplasms may be a hitherto-unrecognized type of inflammatory hepatocellular tumor arising in advanced alcoholic liver disease Sasaki, Motoko;Yoneda, Norihide;Sato, Yasunori;Nakanuma, Yasuni HEPATOLOGY 56巻 0号 467A-467A頁 2012
  • Intraepithelial infiltration of ORM1-like protein 3 (ORMDL3) -expressing cells may be closely related to the pathogenesis of primary biliary cirrhosis Sasaki, Motoko;Miyakoshi, Masami;Sato, Yasunori;Nakanuma, Yasuni HEPATOLOGY 56巻 0号 1139A-1140A頁 2012
  • Validation of a new histological staging and grading system for primary biliary cirrhosis in comparison with classical systems Kakuda, Yuko;Harada, Kenichi;Sawada-Kitamura, Seiko;Ikeda, Hiroko;Sato, Yasunori;Sasaki, Motoko;Nakanuma, Yasuni HEPATOLOGY 56巻 0号 1141A-1141A頁 2012
  • Clinicopathologic Significance of Combined Hepatocellular-Cholangiocarcinoma With Stem Cell Subtype Components With Reference to the Expression of Putative Stem Cell Markers Ikeda, Hiroko;Harada, Kenichi;Sato, Yasunori;Sasaki, Motoko;Yoneda, Non Hide;Kitamura, Seiko;Sudo, Yoshiko;Ooi, Akishi;Nakanuma, Yasuni AMERICAN JOURNAL OF CLINICAL PATHOLOGY 140巻 3号 329-340頁 2013 
  • A possible involvement of endoplasmic reticulum stress in biliary epithelial autophagy and senescence in primary biliary cirrhosis M. Y.-M. Sasaki, M.;Sato, Y.;Nakanuma, Y. J Gastroenterol 50巻 9号 984-95頁 2015
  • Intrahepatic cholangiocarcinoma escapes from growth inhibitory effect of transforming growth factor-beta1 by overexpression of cyclin D1 Zen Y, Harada K, Sasaki M, et al. LABORATORY INVESTIGATION 85巻 4号 572-581頁 2005/04 査読有 原著論文 研究論文(学術雑誌)
  • Frequent p16ink4a inactivation is an early and frequent event of intraductal papillary neoplasm of the liver arising in hepatolithiasis.  Ishikawa A, Sasaki M, Sato Y, et al. HUMAN PATHOLOGY 35巻 12号 1505-1514頁 2004/12 査読有 原著論文 研究論文(学術雑誌)
  • Metachronous intracystic and intraductal papillary neoplasms of the biliary tree H. S. Sato, Y.;Harada, K.;Sasaki, M.;Hirano, K.;Nakanuma, Y. World J Gastroenterol 19巻 36号 1543303頁 2013
  • Histological characteristics of biliary intraepithelial neoplasia-3 and intraepithelial spread of cholangiocarcinoma Y. H. Sato, K.;Sasaki, M.;Nakanuma, Y. Virchows Arch 462巻 4号 421-7頁 2013
  • Clinicopathological significance of S100 protein expression in cholangiocarcinoma Y. H. Sato, K.;Sasaki, M.;Nakanuma, Y. J Gastroenterol Hepatol 28巻 8号 1422-9頁 2013
  • A case of mucinous cystic neoplasm of the liver: description of Sonazoid-enhanced ultrasound imaging and histopathologic findings K. M. Sugimoto, F.;Kono, S.;Sasaki, M.;Nakanuma, Y.;Imai, Y. J Med Ultrason (2001) 40巻 3号 243-50頁 2013
  • Epidermal growth factor induces cytokeratin 19 expression accompanied by increased growth abilities in human hepatocellular carcinoma Yoneda, Norihide;Sato, Yasunori;Kitao, Azusa;Ikeda, Hiroko;Sawada-Kitamura, Seiko;Miyakoshi, Masami;Harada, Kenichi;Sasaki, Motoko;Matsui, Osamu;Nakanuma, Yasuni LABORATORY INVESTIGATION 91巻 2号 262-272頁 2011
  • Characterization of possible precursors of intraductal papillary neoplasm of the bile duct involving peribiliary glands Sato, Yasunori;Harada, Kenichi;Sasaki, Motoko;Nakanuma, Yasuni HEPATOLOGY 56巻 0号 607A-608A頁 2012
  • EFFECTS OF MTOR INHIBITORS ON THE BILIARY DYSGENESIS OF THE PCK RAT, AN ANIMAL MODEL OF CAROLI'S DISEASE Sato, Yasunori;Ren, Xiang Shan;Harada, Kenichi;Sasaki, Motoko;Nakanuma, Yasuni HEPATOLOGY 54巻 0号 767A-767A頁 2011
  • Perihilar cholangiocarcinoma and pancreatic ductal adenocarcinoma share similar histopathologies, immunophenotypes and development-related molecules: a suggestion of a common carcinogenetic process Sato, Yasunori;Gandou, Chihiro;Harada, Kenichi;Sasaki, Motoko;Nakanuma, Yasuni HEPATOLOGY 56巻 0号 620A-620A頁 2012
  • Pathological spectrum of intrahepatic cholangiocarcinoma arising in non-biliary chronic advanced liver diseases Nakanuma, Yasuni;Xu, Jing;Harada, Kenichi;Sato, Yasunori;Sasaki, Motoko;Ikeda, Hiroko;Kim, Jihun;Yu, Eunsil PATHOLOGY INTERNATIONAL 61巻 5号 298-305頁 2011
  • Autophagy may occur at an early stage of cholangiocarcinogenesis via biliary intraepithelial neoplasia HUMAN PATHOLOGY 46巻 2号 202-209頁 2015/01/01 
  • Benign Hepatocellular Nodules: Hepatobiliary Phase of Gadoxetic Acid-enhanced MR Imaging Based on Molecular Background N. M. Yoneda, O.;Kitao, A.;Kozaka, K.;Kobayashi, S.;Sasaki, M.;Yoshida, K.;Inoue, D.;Minami, T.;Gabata, T. Radiographics 36巻 7号 2010-2027頁 2016
  • New concept: cellular senescence in pathophysiology of cholangiocarcinoma M. N. Sasaki, Y. Expert Rev Gastroenterol Hepatol 10巻 5号 625-38頁 2016
  • Loss of ARID1A Expression Presents a Novel Pathway of Carcinogenesis in Biliary Carcinomas M. N. Sasaki, T.;Sato, Y.;Nakanuma, Y. Am J Clin Pathol 145巻 6号 815-25頁 2016
  • Mutational landscape of combined hepatocellular carcinoma and cholangiocarcinoma, and its clinicopathological significance M. S. Sasaki, Y.;Nakanuma, Y. Histopathology 70巻 3号 423-434頁 2017
  • Bile Acids and Deregulated Cholangiocyte Autophagy in Primary Biliary Cholangitis M. N. Sasaki, Y. Dig Dis 35巻 3号 210-216頁 2017
  • Stress-induced cellular responses and cell death mechanisms during inflammatory cholangiopathies M. N. Sasaki, Y. Clin Res Hepatol Gastroenterol 41巻 2号 129-138頁 2017
  • Characterization of intraductal papillary neoplasm of bile duct with respect to histopathologic similarities to pancreatic intraductal papillary mucinous neoplasm Y. K. Nakanuma, Y.;Uesaka, K.;Miyata, T.;Yamamoto, Y.;Fukumura, Y.;Sato, Y.;Sasaki, M.;Harada, K.;Takase, M. Hum Pathol 51巻 103-13頁 2016
  • Altered intrahepatic microcirculation of idiopathic portal hypertension in relation to glutamine synthetase expression Y. H. Sato, K.;Sasaki, M.;Nakanuma, Y. Hepatol Res 45巻 13号 1323-30頁 2015
  • Biliary adenofibroma with ominous features of imminent malignant changes A. B. Tsutsui, Y.;Sato, Y.;Miyake, H.;Sawada-Kitamura, S.;Shibata, H.;Kakuda, Y.;Harada, K.;Sasaki, M.;Nakanuma, Y. Clin J Gastroenterol 7巻 5号 441-8頁 2014
  • Pathological diagnosis of flat epithelial lesions of the biliary tract with emphasis on biliary intraepithelial neoplasia Y. S. Sato, M.;Harada, K.;Aishima, S.;Fukusato, T.;Ojima, H.;Kanai, Y.;Kage, M.;Nakanuma, Y.;Tsubouchi, H.;Hepatolithiasis Subdivision of Intractable Hepatobiliary Diseases Study Group of, Japan J Gastroenterol 49巻 1号 64-72頁 2014
  • Different carcinogenic process in cholangiocarcinoma cases epidemically developing among workers of a printing company in Japan Y. K. Sato, S.;Takemura, S.;Sugawara, Y.;Tanaka, S.;Fujikawa, M.;Arimoto, A.;Harada, K.;Sasaki, M.;Nakanuma, Y. Int J Clin Exp Pathol 7巻 8号 4745-54頁 2014
  • Histological Characterization of Biliary Intraepithelial Neoplasia with respect to Pancreatic Intraepithelial Neoplasia Y. H. Sato, K.;Sasaki, M.;Nakanuma, Y. Int J Hepatol 2014巻 678260頁 2014
  • Cystic and micropapillary epithelial changes of peribiliary glands might represent a precursor lesion of biliary epithelial neoplasms Y. H. Sato, K.;Sasaki, M.;Nakanuma, Y. Virchows Arch 464巻 2号 157-63頁 2014
  • Immunostaining for polycomb group protein EZH2 and senescent marker p16INK4a may be useful to differentiate cholangiolocellular carcinoma from ductular reaction and bile duct adenoma M. M. Sasaki, T.;Kakuda, Y.;Sato, Y.;Nakanuma, Y. Am J Surg Pathol 38巻 3号 364-9頁 2014
  • Clinicopathological characteristics of serum amyloid A-positive hepatocellular neoplasms/nodules arising in alcoholic cirrhosis M. Y. Sasaki, N.;Sawai, Y.;Imai, Y.;Kondo, F.;Fukusato, T.;Yoshikawa, S.;Kobayashi, S.;Sato, Y.;Matsui, O.;Nakanuma, Y. Histopathology 66巻 6号 836-45頁 2015
  • Clinicopathological significance of 'subtypes with stem-cell feature' in combined hepatocellular-cholangiocarcinoma M. S. Sasaki, H.;Kakuda, Y.;Sato, Y.;Choi, J. H.;Nakanuma, Y. Liver Int 35巻 3号 1024-35頁 2015
  • Serum Amyloid A-Positive Hepatocellular Neoplasm: A New Type of Tumor Arising in Patients with Advanced Alcoholic Disease M. N. Sasaki, Y. Dig Dis 33巻 5号 648-54頁 2015
  • Cellular senescence in biliary pathology. Special emphasis on expression of a polycomb group protein EZH2 and a senescent marker p16INK4a in bile ductular tumors and lesions M. N. Sasaki, Y. Histol Histopathol 30巻 3号 267-75頁 2015
  • Autophagy may occur at an early stage of cholangiocarcinogenesis via biliary intraepithelial neoplasia M. N. Sasaki, T.;Sato, Y.;Nakanuma, Y. Hum Pathol 46巻 2号 202-9頁 2015
  • In recurrent primary biliary cirrhosis after liver transplantation, biliary epithelial cells show increased expression of mitochondrial proteins M. H. Sasaki, M.;Yeh, M. M.;Nakanuma, Y. Virchows Arch 467巻 4号 417-25頁 2015
  • Autophagy and senescence in fibrosing cholangiopathies Y. S. Nakanuma, M.;Harada, K. J Hepatol 62巻 4号 934-45頁 2015
  • What are the precursor and early lesions of peripheral intrahepatic cholangiocarcinoma? Y. T. Nakanuma, A.;Ren, X. S.;Harada, K.;Sato, Y.;Sasaki, M. Int J Hepatol 2014巻 805973頁 2014
  • Proposal of a new disease concept "biliary diseases with pancreatic counterparts". Anatomical and pathological bases Y. H. Nakanuma, K.;Sasaki, M.;Sato, Y. Histol Histopathol 29巻 1号 42745頁 2014
  • Adenovirus pneumonia presenting with nodular shadows on chest X-ray in two unrelated allogeneic bone marrow transplant recipients K. K. Mochizuki, Y.;Hosokawa, K.;Ohata, K.;Yamazaki, H.;Takami, A.;Sasaki, M.;Sato, Y.;Nakanuma, Y.;Nakao, S. Intern Med 53巻 5号 499-503頁 2014
  • Clinicopathological study of primary biliary cirrhosis with interface hepatitis compared to autoimmune hepatitis M. K. Kobayashi, Y.;Harada, K.;Sato, Y.;Sasaki, M.;Ikeda, H.;Terada, M.;Mukai, M.;Kaneko, S.;Nakanuma, Y. World J Gastroenterol 20巻 13号 3597-608頁 2014
  • Multiple hypervascular FNH-like lesions in a patient with no history of alcohol abuse or chronic liver disease J. M. Tani, H.;Sasaki, M.;Nakanuma, Y.;Nomura, T.;Yoneyama, H.;Morishita, A.;Kobara, H.;Hirohito, M.;Himoto, T.;Masaki, T. Intern Med 52巻 19号 2225-30頁 2013
  • Chemokine-chemokine receptor CCL2-CCR2 and CX3CL1-CX3CR1 axis may play a role in the aggravated inflammation in primary biliary cirrhosis M. M. Sasaki, M.;Sato, Y.;Nakanuma, Y. Dig Dis Sci 59巻 2号 358-64頁 2014
  • Infiltration of inflammatory cells expressing mitochondrial proteins around bile ducts and in biliary epithelial layer may be involved in the pathogenesis in primary biliary cirrhosis M. K. Sasaki, Y.;Miyakoshi, M.;Sato, Y.;Nakanuma, Y. J Clin Pathol 67巻 6号 470-6頁 2014
  • Hyperplastic hepatocellular nodule with localized hemangiomatosis: A hither-to unrecognized type of hypervascular hepatic lesion M. I. Sasaki, T.;Hatanaka, K. C.;Nakanuma, Y. Hepatol Res 44巻 10号 E77-83頁 2014
  • Activation of the PI3K/mTOR pathway is involved in cystic proliferation of cholangiocytes of the PCK rat X. S. S. Ren, Y.;Harada, K.;Sasaki, M.;Furubo, S.;Song, J. Y.;Nakanuma, Y. PLoS One 9巻 1号 e87660頁 2014
  • GNAS and KRAS mutations are common in intraductal papillary neoplasms of the bile duct M. M. Sasaki, T.;Nitta, T.;Sato, Y.;Nakanuma, Y. PLoS One 8巻 12号 e81706頁 2013
  • Overexpression of enhancer of zeste homolog 2 and MUC1 may be related to malignant behaviour in intraductal papillary neoplasm of the bile duct M. M. Sasaki, T.;Yoneda, N.;Nomoto, K.;Tsuneyama, K.;Sato, Y.;Nakanuma, Y. Histopathology 62巻 3号 446-57頁 2013
  • Increased expression of mitochondrial proteins associated with autophagy in biliary epithelial lesions in primary biliary cirrhosis M. M. Sasaki, M.;Sato, Y.;Nakanuma, Y. Liver Int 33巻 2号 312-20頁 2013
  • Adenovirus pneumonia presenting with nodular shadows on chest X-ray in two unrelated allogeneic bone marrow transplant recipients Internal Medicine 53巻 5号 499-503頁 2014/01/01 
  • Chemokines CCL2 and CX3CL1 as senescence-associated secretory phenotypes may play a role in aggravated inflammation in primary biliary cirrhosis Sasaki, Motoko;Miyakoshi, Masami;Sato, Yasunori;Nakanuma, Yasuni HEPATOLOGY 56巻 0号 1135A-1136A頁 2012
  • A possible involvement of p62/sequestosome-1 in the process of biliary epithelial autophagy and senescence in primary biliary cirrhosis Liver International 32巻 3号 487-499頁 2012/03/01 
  • Multiple hypervascular FNH-like lesions in a patient with no history of alcohol abuse or chronic liver disease Internal Medicine 52巻 19号 2225-2230頁 2013/10/08 
  • A case of mucinous cystic neoplasm of the liver: Description of Sonazoid-enhanced ultrasound imaging and histopathologic findings Journal of Medical Ultrasonics 40巻 3号 243-250頁 2013/07/01 
  • Pathological diagnosis of flat epithelial lesions of the biliary tract with emphasis on biliary intraepithelial neoplasia Journal of Gastroenterology 49巻 1号 64-72頁 2014/01/01 
  • Proposal of a new disease concept biliary diseases with pancreatic counterparts. Anatomical and pathological bases Histology and Histopathology 29巻 1号 1-10頁 2014/01/01 
  • Autophagy may occur at an early stage of cholangiocarcinogenesis via biliary intraepithelial neoplasia Human Pathology 46巻 2号 202-209頁 2015/01/01 
  • Histological characteristics of biliary intraepithelial neoplasia-3 and intraepithelial spread of cholangiocarcinoma Virchows Archiv 462巻 4号 421-427頁 2013/04/01 
  • Hyperplastic hepatocellular nodule with localized hemangiomatosis: A hither-to unrecognized type of hypervascular hepatic lesion Hepatology Research 44巻 10号 E77-E83頁 2014/01/01 
  • GNAS and KRAS mutations are common in intraductal papillary neoplasms of the bile duct PLoS ONE 8巻 12号 2013/12/02 
  • Serum amyloid A-positive hepatocellular neoplasms in the resected livers from 3 patients with alcoholic cirrhosis Histology and Histopathology 28巻 11号 1499-1505頁 2013/11/01 
  • Induction of elastin expression in vascular endothelial cells relates to hepatoportal sclerosis in idiopathic portal hypertension: Possible link to serum anti-endothelial cell antibodies Clinical and Experimental Immunology 167巻 3号 532-542頁 2012/03/01 
  • Autophagy may promote carcinoma cell invasion and correlate with poor prognosis in cholangiocarcinoma International Journal of Clinical and Experimental Pathology 7巻 8号 4913-4921頁 2014/01/01 
  • α-Fetoprotein-producing gastric carcinoma and combined hepatocellular and cholangiocarcinoma show similar morphology but different histogenesis with respect to SALL4 expression Human Pathology 43巻 11号 1955-1963頁 2012/11/01 
  • Participation of bile ductular cells in the pathological progression of non-alcoholic fatty liver disease Journal of Clinical Pathology 64巻 7号 564-570頁 2011/07/01 
  • Clinicopathological study of primary biliary cirrhosis with interface hepatitis compared to autoimmune hepatitis World Journal of Gastroenterology 20巻 13号 3597-3608頁 2014/04/07 
  • Chemokine-chemokine receptor CCL2-CCR2 and CX3CL1-CX3CR1 axis may play a role in the aggravated inflammation in primary biliary cirrhosis Digestive Diseases and Sciences 59巻 2号 358-364頁 2014/02/01 
  • Clinicopathologic significance of combined hepatocellular- cholangiocarcinoma with stem cell subtype components with reference to the expression of putative stem cell markers American Journal of Clinical Pathology 140巻 3号 329-340頁 2013/09/01 
  • Characterization of hepatocellular adenoma based on the phenotypic classification: The Kanazawa experience Hepatology Research 41巻 10号 982-988頁 2011/10/01 
  • Activation of the PI3K/mTOR pathway is involved in cystic proliferation of cholangiocytes of the PCK rat PLoS ONE 9巻 1号 2014/01/30 
  • Bile duct expression of pancreatic and duodenal homeobox 1 in perihilar cholangiocarcinogenesis Histopathology 61巻 2号 266-276頁 2012/08/01 
  • Biliary adenofibroma with ominous features of imminent malignant changes Clinical Journal of Gastroenterology 7巻 5号 441-448頁 2014/01/01 
  • Biliary infection may exacerbate biliary cystogenesis through the induction of VEGF in cholangiocytes of the polycystic kidney (PCK) rat American Journal of Pathology 179巻 6号 2845-2854頁 2011/12/01 
  • Clinicopathological significance of S100 protein expression in cholangiocarcinoma Journal of Gastroenterology and Hepatology (Australia) 28巻 8号 1422-1429頁 2013/01/01 
  • Cystic and micropapillary epithelial changes of peribiliary glands might represent a precursor lesion of biliary epithelial neoplasms Virchows Archiv 464巻 2号 157-163頁 2014/02/01 
  • Different carcinogenic process in cholangiocarcinoma cases epidemically developing among workers of a printing company in Japan International Journal of Clinical and Experimental Pathology 7巻 8号 4745-4754頁 2014/01/01 
  • Infiltration of inflammatory cells expressing mitochondrial proteins around bile ducts and in biliary epithelial layer may be involved in the pathogenesis in primary biliary cirrhosis Journal of Clinical Pathology 67巻 6号 470-476頁 2014/01/01 
  • Intrahepatic cholangiocarcinoma arising in chronic advanced liver disease and the cholangiocarcinomatous component of hepatocellular cholangiocarcinoma share common phenotypes and cholangiocarcinogenesis Histopathology 59巻 6号 1090-1099頁 2011/12/01 
  • Intrahepatic cholangiocarcinomas in cirrhosis are hypervascular in comparison with those in normal livers Liver International 32巻 7号 1156-1164頁 2012/08/01 
  • Metachronous intracystic and intraductal papillary neoplasms of the biliary tree World Journal of Gastroenterology 19巻 36号 6125-6126頁 2013/09/28 
  • Evaluation of a new histologic staging and grading system for primary biliary cirrhosis in comparison with classical systems Human Pathology 44巻 6号 1107-1117頁 2013/06/01 
  • Beta-catenin-activated hepatocellular adenoma showing hyperintensity on hepatobiliary-phase gadoxetic-enhanced magnetic resonance imaging and overexpression of OATP8 Japanese Journal of Radiology 30巻 9号 777-782頁 2012/11/01 
  • Hilar cholangiocarcinoma and pancreatic ductal adenocarcinoma share similar histopathologies, immunophenotypes, and development-related molecules Human Pathology 44巻 5号 811-821頁 2013/05/01 
  • Immunohistochemical characteristics and malignant progression of hepatic cystic neoplasms in comparison with pancreatic counterparts Human Pathology 43巻 12号 2177-2186頁 2012/12/01 
  • Participation of peribiliary glands in biliary tract pathophysiologies World Journal of Hepatology 5巻 8号 425-432頁 2013/09/24 
  • Heat shock proteins 27 and 70 are potential biliary markers for the detection of cholangiocarcinoma American Journal of Pathology 180巻 1号 123-130頁 2012/01/01 

講演・口頭発表等

  • Bile acids and cholangiocyte autophagy(2016)
  • Recent Advances in Liver Pathology. Cholangiocarcinoma and precursor lesions: An involvement of cellular senescence in cholangiocarcinogenesis.(2015)
  • Enhanced VASH1 expression in splenic sinus lining cells relates to splenomegaly in IPH(2016)
  • Mutations of p53, ARID 1A and KRAS mutations and their association with “subtypes with stem-cell feature” in combined hepatocellular-cholangiocellular carcinoma.
  • Increased expression of ORM1-like protein 3 (ORMDL3) in biliary epithelial cells may be related to the pathogenesis of primary biliary cirrhosis.(2015)

全て表示

  • ARID 1A mutations may represent a novel pathway of carcinogenesis in biliary carcinomas.(2015)
  • Correlation of destruction of canals of Hering with the progression of the primary biliary cirrhosis stage(2013)
  • Histological characterization of biliary intraepithelial neoplasia with respect to pancreatic intraepithelial neoplasia(2013)
  • Autophagy may be an early event in the stepwise carcinogenesis via biliary intraepithelial neoplasia in cholangiocarcinoma associated with hepatolithiasis. (2014)
  • A possible involvement of endoplasmic reticulum stress in the process of biliary epithelial autophagy and endoplasmic reticulum stress in the process of biliary epithelial autophagy and senescence in primary biliary cirrhosis. (2014)
  • Cellular senescence in hepatobiliary diseases. (2008)
  • Pathology of hepatolithiasis with an emphasis on metaplasia of biliary mucosa. (2007)
  • Gastrointestinal metaplasia and intrahepatic cholangiocarcinoma in hepatolithiasis.(会議名:One-day Symposium on International Collaborative Study on Intra-Hepatic Stone (HIS) and Cholangiocellular Carcinoma (CCC))(2002)
  • Short Course: Chronic Cholangitis and Cholangiocarcinoma: Hepatolithiasis and cholangiocarcinoma: phenotypic and changes.(2000)
  • シンポジウム2 肝細胞腺腫の亜分類の新 しい考え方 5. 肝細胞腺腫は悪性転化するか? -病理の立場より- (会議名:第20回肝血流動態機能イメージ研究会)(2014)
  • シンポジウム:胆管上皮内異型病変の組織 細胞化学的解析: 胆管癌早期診断へのアプローチ. (会議名:第52回日本組織細胞 化学会総会・学術集会,)(2011)
  • シンポジウム: 肝胆膵疾患の免疫病態の新たな展開. 原発性胆汁性肝硬変での老化胆管細胞による免疫調節. (会議名:第47回日本消化器免疫学会総会)(2010)
  • シンポジウム:「Hepatic stem cell と cancer stem cell」 肝細胞癌発生過程におけるHepatic progenitor cell と細胞老化回避機構の関与. (会議名:第12回日本肝臓学会 大会)(2008)
  • シンポジウム:「自己免疫性肝疾患に創流を求めて」   自己免疫性肝疾患の胆管病変(PBC,PSC,AIPの胆管病変) (会議名: 第44回日本 肝臓学会総会)(2008)
  • シンポジウム:胆道癌の発生機序: 胆道癌多段階発癌過程における癌遺伝子 誘導性細胞老化(oncogene-induced senescence)と細胞老化エスケープ機構 の関与. (会議名:第43回日本胆道学会学術集会)(2007)
  • シンポジウム「酸化ストレスと肝 疾患」原発性胆汁性肝硬変 (PBC) における胆管上皮細胞老化の制御機構: 酸化ストレスとpolycomb 蛋白 bmi-1 の関与を中心に. (会議名:第36回日本肝臓学会西部会)(2005)
  • シンポジュウム「肝内胆管拡張 はなぜ生ずるのか」:肝内結石症の肝内胆管上皮でのムチンコア蛋白プロフィール(会議名:第3回日本肝臓学会大会)(1999)
  • B演説:日本における肝細胞腺腫の臨床病理学的検討(会議名:第57回日本病理学会秋期特別総会)(2011)
  • A演説:細胞老化に着目した肝胆道系疾患の発生・進展機構 の解明. (会議名:第55回日本病理学会秋期特別総会)(2009)
  • Hepatocytes growth factor activator type 1 (HAI-1) is augmented in intrahepatic small bile ducts in primary biliary cirrhosis(2005)
  • Decreased expression of bmi1 is closely associated with cellular senescence in damaged small bile ducts in primary biliary cirrhosis.(2005)
  • Augmented and irregularly distributed expression of trefoil factor family-1,2,3 and their putative receptor in small bile ducts in primary biliary cirrhosis. (2002)
  • Autophagy may precede cellular senescence of bile ductular cells in ductuar reaction in  primary biliary cirrhosis. (2010)
  • A Possible involvement of P62/sequestosome-1 in the process of biliary epithelial autophagy and senescence in primary biliary cirrhosis. (2010)
  • A possible involvement of autophagy in the process of biliary epithelial senescence in primary biliary cirrhosis.(2009)
  • modulation of microenvironment by senescent biliary epithelial cells in the pathogenesis of bile duct lesions in primary biliary cirrhosis.(2009)
  • A case of intraductal/intracystic papillary neoplasm of the bile duct (IPN-B).(2008)
  • Cellular senescence of biliary epithelial cells characterizes the damaged small bile ducts in primary biliary cirrhosis. (2008)
  • Cellular senescence of bile ductular cells may be involved in the pathophysiology in ductular rections in chronic liver diseases.(2008)
  • ATM/p53/p21 pathway is involved in the oxidative stress-induced cellular senescence in biliary epithelial cell in primary biliary cirrhosis(2006)
  • Inflammatory hepatocellular adenomas arise in alcoholic cirrhosis.(2011)
  • Increased expression of mitochondrial proteins associated with autophagy in the biliary epithelial lesions in primary biliary cirrhosis.(2011)
  • The overexpression of enhancer of zeste homolog 2 (EZH2) may be related to malignant behaviors in intraductal papillary neoplasm of the bile duct(2012)
  • The deregulated autophagy of mitochondria may be involved in the pathogenesis in primary biliary cirrhosis. (2012)
  • Serum amyloid A-positive hepatocellular neoplasms may be a hitherto-unrecognized type of inflammatory hepatocellular tumor arising in advanced alcoholic liver disease(2012)
  • Chemokines CCL2 and CX3CL1 as senescence-associated secretory phenotypes may play a role in aggravated inflammation in primary biliary cirrhosis(2012)
  • Intraepithelial infiltration of ORM1-like protein 3 (ORMDL3) –expressing cells may be closely related to the pathogenesis of primary biliary cirrhosis.(2012)
  • Clinicopathological Characteristics of serum amyloid a-positive hepatocellular neoplasms arising in advanced alcoholic liver disease(2013)
  • Infiltration of inflammatory cells expressing mitochondrial proteins around bile ducts and intraepithelial layer may be involved to the pathogenesis in primary biliary cirrhosis. (2013)
  • Prevalence and significance of ´Subtypes with stem-cell feature´ in combined hepatocellular- cholangiocarcinoma and hepatocellular carcinoma. (2013)
  • Infiltration of macrophages and plasma cells with coarse granular expression of mitochondrial proteins around bile ducts and intraepithelial layer may be involved in the pathogenesis of bile duct lesions in primary biliary cirrhosis. (2013)
  • Serum amyloid A (SAA)-positive hepatocellular neoplasms and SAA-negative focal nodular hyperplasia-like nodules arising in alcoholic cirrhosis.(2013)
  • GNAS and KRAS mutations are common in intraductal papillary neoplasm of the bile duct. (2013)

芸術・フィールドワーク

特許

共同研究希望テーマ

○肝胆道系疾患の病理と病態機序

科研費

○基盤研究(C)(一般)「自己免疫性疾患におけるオートファジー異常の役割の解明」(2015-2017) 代表者
○基盤研究(C)(一般)「オートファジー異常に着目した原発性胆汁性肝硬変の新たな解析」(2012-2014)
○基盤研究(C)「細胞老化に着目した肝臓病の新たな解析」(2009-2011) 代表者
○基盤研究C「原発性胆汁性肝硬変における胆管消失発生の分子 機構:胆管細胞老化の関与を中心に 」(2006-)
○基盤研究C「肝内胆管消失症候群における粘膜上皮再生・修復 の分子機構 」(2003-) 代表者
○奨励研究(A)「増生細胆管でのアポムチンサブタイプの発現とその意義:増生細胆管は肝ステムセルか?」(1997-) 代表者
○奨励研究 A「肝内胆管系におけるムチンコア蛋白の正常分布 と疾患に伴う変動;肝内結石症を中心に 」(1996-) 代表者
○奨励研究 A「ウイルス性肝硬変の再生結節内の”ルイスY抗原 陰性巣”;新しい癌関連病巣か 」(1995-) 代表者
○奨励研究 A「胆汁中粘液糖蛋白の解析:肝内胆管病変との 対比を中心に 」(1994-) 代表者
○奨励研究 A「肝内結石症に合併する肝内胆管癌の発生,進展 に関する免疫組織化学的検討 」(1993-) 代表者

学域・学類担当授業科目

○病態の形態と機構機序(2017)
○1年生チュートリアル(2016)
○病態の形態と機構機序(2016)

大学院担当授業科目

○形態機能病理学特論(CPC)(2016)

他大学の客員教授

教育活動(FD)に関する研究

国際事業協力

留学生参加の社会活動

審議会等の参加

講演可能なテーマ

○肝胆道系疾患の病理

その他公的社会活動

このページの先頭へ