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研究者情報

データ更新日:2017年04月18日

片桐 孝和 (かたぎり たかまさ) 助教 KATAGIRI Takamasa

メール

所属組織・役職等

医薬保健研究域 保健学系 病態検査学講座

教育分野

【学士課程】
医薬保健学域 保健学類 検査技術科学専攻
【大学院前期課程】
医薬保健学総合研究科 保健学専攻
【大学院後期課程】
医薬保健学総合研究科 保健学専攻

所属研究室等

学歴

【出身大学院】
金沢大学 博士課程  修了
【出身大学】
金沢大学  卒業

職歴

生年月

所属学会

日本臨床免疫学会
日本免疫学会
日本血液学会
日本PNH研究会

学内委員会委員等

○広報委員(2016-)
○クラス担任(2015-2018)
○つるまだより編集委員(2016-)

受賞学術賞

○第71回日本血液学会学術集会 優秀ポスター賞(2009/10/14)
○51th American Society of Hematology Annual Meeting ASH Abstract Achievement Awards(2009/12/07)
○金沢大学大学院医学系研究科 研究奨励支援 (2010/12/01)
○52th American Society of Hematology Annual Meeting ASH Abstract Achievement Awards(2010/12/07)
○第72回日本血液学会学術集会 学会奨励賞(2011/09/16)
○公益財団法人 武田科学振興財団医学系研究奨励(2012/07/26)
○公益財団法人 先進医薬研究振興財団 血液医学分野 一般研究助成(2014/12/01)
○第7回北陸銀行若手研究者助成(2015/03/30)

専門分野

免疫学、血液内科学

専門分野キーワード

自己免疫疾患、免疫学

研究課題

自己免疫性造血器疾患における病態解明および新規検査法・治療法の確立

白血病および骨髄不全症の病態解明および新規検査法・治療法の確立

著書

  • 再生不良性貧血における6番染色体短腕CNN-LOHによるHLAアレル欠失血球の出現とその臨床的意義 科学評論社 2013/06 原著書 共著

論文

  • Mismatch of minor histocompatibility antigen contributes to a graft-versus-leukemia effect rather than to acute GVHD, resulting in long-term survival after HLA-identical stem cell transplantation in Japan.  Bone Marrow Transplant 38巻 10号 681-6頁 2006/11 査読有 原著論文 研究論文(学術雑誌)
  • Identification of a WT1 protein-derived peptide, WT1, as a HLA-A 0206-restricted, WT1-specific CTL epitope.  Microbiol Immunol 52巻 11号 551-8頁 2008/11 査読有 原著論文 研究論文(学術雑誌)
  • Biased usage of BV gene families of T-cell receptors of WT1 (Wilms' tumor gene)-specific CD8+ T cells in patients with myeloid malignancies.  Cancer Sci 101巻 3号 594-600頁 2010/03 査読有 原著論文 研究論文(学術雑誌)
  • GPI-anchored protein-deficient T cells in patients with aplastic anemia and low-risk myelodysplastic syndrome: implications for the immunopathophysiology of bone marrow failure. Eur J Haematol. 86巻 3号 226-36頁 2011/03 査読有 原著論文 研究論文(学術雑誌)
  • Safety of pre-engraftment prophylactic foscarnet administration after allogeneic stem cell transplantation.  Transpl Infect Dis. 2011/07 査読有 原著論文 研究論文(学術雑誌)

全て表示

  • Preemptive therapy of human herpesvirus-6 encephalitis with foscarnet sodium for high-risk patients after hematopoietic SCT.  Bone Marrow Transplant 46巻 6号 863頁 2011/09 査読有 原著論文 研究論文(学術雑誌)
  • Sustained trilineage hematopoietic recovery in a patient with refractory anemia, del(13)(q12q22), and paroxysmal nocturnal hemoglobinuria-type cells treated with immunosuppressive therapy. Leuk Res.  35巻 9号 147頁 2011/09 査読有 原著論文 研究論文(学術雑誌)
  • Frequent loss of HLA alleles associated with copy number-neutral 6pLOH in acquired aplastic anemia. Blood 118巻 25号 6601-6609頁 2011/09 査読有 原著論文 研究論文(学術雑誌)
  • Favorable outcome of patients who have 13q deletion: a suggestion for revision of the WHO 'MDS-U' designation. Haematologica 2012/01 査読有 原著論文 研究論文(学術雑誌)
  • Immunologically escaped hematopoiesis caused by HLA allelic loss in patients with aplastic anemia]. Rinsho Ketsueki 53巻 7号 651-7頁 2012/07 査読有 総説 研究論文(学術雑誌)
  • Individual hematopoietic stem cells in human bone marrow of patients with aplastic anemia or myelodysplastic syndrome stably give rise to limited cell lineages. STEM CELLS 31巻 3号 536-46頁 2013/03 査読有 原著論文 研究論文(学術雑誌)
  • Increased glycosylphosphatidylinositol-anchored protein-deficient granulocytes define a benign subset of bone marrow failures in patients with trisomy 8. Eur J Haematol.  2014/11/18 査読有 原著論文 研究論文(学術雑誌)
  • Induction of HLA-B*40:02-restricted T cells possessing cytotoxic and suppressive functions against haematopoietic progenitor cells from a patient with severe aplastic anaemia Br J Haematol.  2015 査読有 原著論文 研究論文(学術雑誌)
  • Somatic Mutations and Clonal Hematopoiesis in Aplastic Anemia N Engl J Med. 373巻 1号 35-47頁 2015 査読有 原著論文 研究論文(学術雑誌)
  • Paroxysmal nocturnal hemoglobinuria induced by the occurrence of BCR-ABL in a PIGA mutant hematopoietic progenitor cell Leukemia 2015 査読有 原著論文 研究論文(学術雑誌)
  • Cyclosporine restores hematopoietic function by compensating for decreased Tregs in patients with pure red cell aplasia and acquired aplastic anemia. Ann Hematol 95巻 5号 771-81頁 2016 査読有 原著論文 研究論文(学術雑誌)
  • Clinical significance and origin of leukocytes that lack HLA-A allele expression in patients with acquired aplastic anemia. Exp Hematol 2016 査読有 原著論文 研究論文(学術雑誌)
  • Identification of an HLA class I allele closely involved in the auto-antigen presentation in acquired aplastic anemia. Blood 2017 査読有 原著論文 研究論文(学術雑誌)

講演・口頭発表等

  • 46th American Society of Hematology (2004.12) California, USA Incompatibility of HA-1 and CD62L polymorphic adhesion molecule induce graft-versus-leukemia effect rather than GVHD resulted in long-term survival in HLA identical myeloablative stem cell transplantation.
  • 50th American Society of Hematology (2008.12.6-9) California, USA GITR Ligand on Leukemic Myeloid Dendritic Cells Suppresses Induction of Leukemia-Associated Antigen-Specific CTLs from Naive CD8+ T Cells.
  • 51th American Society of Hematology Annual Meeting (2009.12) New Orleans, USA. Hematopoietic Stem Cell Differentiation Pathway in Humans Duduced From the Lineage Diversity of PNH-Type Cells in Patients with Bone Marrow Failure.
  • 51th American Society of Hematology Annual Meeting (2009.12.5-8) New Orleans. USA. GPI-AP Deficient Cells Detected Exclusively in T Cells in Patients with Aplastic Anemia: Evidence against An Escape Mechanism for the Initial Proliferation of PIG-A Mutant Hematopoietic Stem Cells.
  • 51th American Society of Hematology Annual Meeting (2009.12.5-8) New Orleans. USA. Clinical Significance of Chromosomal Abnormalities in Patients with Aplastic Anemia and Refractory Anemia Deduced From the Prevalence of PNH-type Cells.

全て表示

  • 51th American Society of Hematology Annual Meeting (2009.12.5-8) New Orleans. USA. GITR Ligation with GITR Ligand On Leukemic Cells Suppresses Induction of Leukemia-Associated Antigen Specific T Cells by Increasing Indoleamine 2, 3-Dioxygenase (IDO) Activity Leading to Kynurenine Secretion.
  • 51th American Society of Hematology Annual Meeting (2009.12.5-8) New Orleans. USA. Significant Impact of IL-17A Gene Polymorphism On Transplant Outcomes After HLA-fully-Matched Unrelated Bone Marrow Transplantation.
  • 2nd International hematological Congress (2010. 4) Nagasaki. Evidence of Common Mechanisms Underlying the Survival Advantage of the PIG-A mutant and 13q- Hematopoietic Stem Cell Clones In Patients with Immune-Mediated Bone Marrow Failure.
  • 52th American Society of Hematology Annual Meeting (2010.12.4-7) Orland. USA. Immunologically-Selected Hematopoiesis Caused by HLA Allelic Loss in Patients with Aplastic Anemia.
  • 53th American Society of Hematology Annual Meeting (2011.12.10-13) San Diego. USA Individual Hematopoietic Stem Cells in Human Bone Marrow Stably Give Rise to Limited Cell Lineages.
  • 53th American Society of Hematology Annual Meeting (2011.12.10-13) New Orleans. USA Frequent Loss of HLA Alleles From Hematopoietic Stem Cells in Patients with Hepatitis-Associated Aplastic Anemia.
  • 53th American Society of Hematology Annual Meeting (2011.12.10-13) New Orleans. USA Bone Marrow Failure with 13q Deletion: A Distinct Clinicopathological Entity with Immune Pathophysiology.
  • 54th American Society of Hematology Annual Meeting (2012.12.8-10) Atlanta. USA. SLIT1 Mutation in Patients with Acquired Aplastic Anemia: Its Relevance in Immune Pathophysiology. oral presentation.
  • 54th American Society of Hematology Annual Meeting (2012.12.8-10) Atlanta. USA. CD109 Deficiency Induces Preferential Proliferation of the Piga Mutant Leukemia Cell Line TF-1 in the Presence of TGF-β.
  • 39th Annual meeting of the European Group for Blood and Marrow Transplantation, , Hematology Medical Congress (2013.4.7-10) ExCel London (London) Detection of leukocytes lacking HLA-A alleles by flow cytometry predicts a response to immunosuppressive therapy in patients with aplastic anemia.
  • 18th EUROPEAN HEMATOLOGY ASSOCIATION. (2013.6.12-16) Sweden. SPECTRUM OF GENETIC ALTERATIONS IN ACQUIRED APLASTIC ANEMIA.
  • 55th American Society of Hematology Annual Meeting (2013.12.7-10) New Orleans. USA Evidence That GPI-AP-Specific CTLs Are Not Involved In The “escape” Of Piga mutant Hematopoietic Stem Cells In Aplastic Anemia.
  • 55th American Society of Hematology Annual Meeting (2013.12.7-10) New Orleans. USA Increased Gene Expression Of The Nr4A Family In Bone Marrow T Cells Of Patients With Early Stage Acquired Aplastic Anemia.
  • 55th American Society of Hematology Annual Meeting (2013. 12.7-10) New Orleans. USA Prevalence, Clone Size and Lineage Diversity Of HLA-A Allele-Lacking Leukocytes In Patients With Acquired Aplastic Anemia.
  • 55th American Society of Hematology Annual Meeting (2013.12.7-10) New Orleans. USA. Spectrum Of Genetic Alterations In Acquired Aplastic Anemia.
  • 19th European Hematology Association (2014.6.12-15) Milano Congressi (Milan) A simple method to detect copy number-neutral 6p-loh in patients with acquired aplastic anemia using duplex quantitative PCR.
  • 56th American Society of Hematology Annual Meeting (2014.12.6-9) San Francisco. USA. Hematopoiesis in Patients with Acquired Aplastic Anemia Is Supported By a Limited Number of CXCR4(-) Cells at the Common Myeloid Progenitor Level.
  • 56th American Society of Hematology Annual Meeting (2014.12.6-9) San Francisco. USA. Chronological Analysis of Clonal Evolution in Acquired Aplastic Anemia.
  • 56th American Society of Hematology Annual Meeting (2014.12.6-9) San Francisco. USA. Resistance of Hematopoietic Stem Cells Lacking the KIR Ligand to Autologous NK Cell Attacks in Patients with Acquired Aplastic Anemia
  • 56th American Society of Hematology Annual Meeting (2014.12.6-9) San Francisco. USA. Donor-Type Aplastic Anemia after Allogeneic Hematopoietic Stem Cell Transplantation: A Common Cause of Late Graft Failure in Patients with Complete Donor Chimerism.
  • 56th American Society of Hematology Annual Meeting (2014.12.6-9) San Francisco. USA. Evidence That HLA-B*40:02 and HLA-Α*31:01 Are Strongly Involved in the Presentation of Autoantigens to CTLs Responsible for the Development of Acquired Aplastic Anemia.
  • 57th American Society of Hematology Annual Meeting (2015.12.3-6) Orland. USA. A Cure for Paroxysmal Nocturnal Hemoglobinuria Using Molecular Targeted Therapy Specific to a Driver Mutation.
  • 57th American Society of Hematology Annual Meeting (2015.12.3-6) Orland. USA. Evidence That T Cells Specific for Non-Hematopoietic Cells Trigger the Development of Acquired Aplastic Anemia.
  • 57th American Society of Hematology Annual Meeting (2015.12.3-6) Orland. USA. Evidence for a Common Immune Pathophysiology in Acquired Aplastic Anemia and Ulcerative Colitis.
  • 57th American Society of Hematology Annual Meeting (2015.12.3-6) Orland. USA. Generation of Ips Cell-Derived Hematopoietic Progenitor Cells from Patients with Acquired Aplastic Anemia Harboring Copy Number Neutral Loss of Heterozygosity of the Short Arm of Chromosome 6.
  • 58th American Society of Hematology Annual Meeting (2016.12.3-6) San Diego. USA. HLA Class I Allele-Lacking Hematopoietic Stem/Progenitor Cells Support Long-Term Clonal Hematopoiesis without Oncogenic Driver Mutations in Acquired Aplastic Anemia.
  • 58th American Society of Hematology Annual Meeting (2016.12.3-6) San Diego. USA. Relatively Low Sensitivity of CD109(-) Hematopoietic Stem/Progenitor Cells (HSPCs) to TGF-β: A Possible Mechanism Responsible for the Preferential Commitment of Piga Mutant HSPCs in Immune-Mediated Bone Marrow Failure.
  • 第70回日本血液学会総会. (2008.10) 京都 「再生不良性貧血における微少PNH型血球の存在:健常者との境界. 」
  • 第71回血液学会学術集会. (2009.10)  京都 「ヒト造血幹細胞の分化経路:PNH形質血球の分布から推測される新しいモデル.」
  • 第15回血液科学セミナー.(2009.11) 東京 「骨髄不全患者におけるPNH型血球からみたヒト造血幹細胞の動態(招待講演)
  • 第二回日本造血腫瘍免疫療法学術集会 (2010.8) 愛媛 「再生不良性貧血患者の末梢血ではHLA欠失により免疫学的攻撃を免れた造血幹細胞由来の白血球が存在する」
  • 第72回血液学会学術集会. (2010.9)  横浜 「Immunologically-selected hematopoiesis caused by HLA allelic loss in patients with aplastic anemia」
  • 第73回血液学会学術集会. (2011.10)  名古屋 「Clinical and pathological significance of leukocyte lacking HLAs in patients with acquired aplastic anemia」. Symposist.
  • 第74回日本血液学会学術集会. (2012.10)  京都 「GPI-AP specific CTL are not involved in the escape of PIGA mutant stem cells in aplastic anemia」
  • 第75回日本血液学会学術集会 2013年10月11-13日 札幌 「Evidence that HSCs are redundant and only a limited number of HSCs support hematopoiesis in humans」
  • 第77回日本血液学会学術集会(2015.10.16-18) 石川 石川県立音楽堂 「Evidence that hematopoietic progenitor cells support long term hematopoiesis in humans.」
  • 第38回日本造血移植学会総会(2016.3.3-3.5) 愛知国際会議場 「6pLOHによるHLA欠失が再生不良性貧血の非血縁者間同種造血幹細胞移植に及ぼす影響」
  • 第78回日本血液学会学術集会(2016.10.13-15) 神奈川 パシフィコ横浜「A GPI-AP deficiency does not confer resistance to CTL or NK cell killing on HSPCs in aplastic anemia」
  • 第78回日本血液学会学術集会(2016.10.13-15) 神奈川 パシフィコ横浜「HLA-class I-lacking HSPCs support long-term clonal hematopoiesis without driver mutations in AA」

芸術・フィールドワーク

特許

○PNH型白血球の検出方法(公開年月:2012/06/28)(特許番号:特許第5791095号)

共同研究希望テーマ

科研費

○若手研究(B)「HLAアレル欠失現象を利用したヒト造血幹細胞制御分子の同定」(2012-2013) 代表者
○若手研究(B)「発作性夜間血色素尿症(PNH)形質を利用したヒト造血幹細胞動態の解明」(2014-2016) 代表者
○新学術領域研究ゲノム支援「HLAアレル欠失現象を利用したヒト造血幹細胞制御分子の同定」(2012-) 代表者
○新学術領域研究ゲノム支援「発作性夜間血色素尿症(PNH)形質を利用したヒト造血幹細胞動態の解明」(2015-) 代表者
○基盤研究(C)「治療関連骨髄性腫瘍の疫学的、分子生物学的研究」(2016-2018) 分担者
○基盤研究(C)「iPS細胞由来ヒト造血幹細胞を用いた自己免疫性造血不全の発症機序の解明」(2017-2019) 代表者

学域・学類担当授業科目

○輸血検査学(2016)
○解剖学実習(2016)
○卒業研究(2016)
○血清・免疫検査学(2016)
○免疫学(2016)
○血液・輸血検査学臨地実習(2016)
○血清・免疫検査学実習(2016)
○生理学演習(2016)
○輸血検査学特論(2016)
○生理学演習(2015)
○卒業研究(2015)
○血清・免疫検査学(2015)
○血清・免疫検査学実習(2015)
○初学者ゼミ(2015)
○血液・輸血検査学臨地実習(2015)
○解剖学実習(2015)
○免疫学(2015)
○輸血検査学(2015)
○血清・免疫検査学(2014)
○輸血検査学(2014)
○卒業研究(2014)
○免疫学(2014)
○血清・免疫検査学実習(2014)
○生理学演習(2014)
○血液・輸血検査学臨地実習(2014)
○医用工学概論実習(2014)
○解剖学実習(2014)

大学院担当授業科目

○血液免疫病態学特論(2016)
○血液免疫病態学演習(2016)
○腫瘍検査学課題研究(2016)
○血液免疫病態学特論(2015)
○血液免疫病態学演習(2015)
○腫瘍検査学課題研究(2015)
○保健学研究方法論(2015)
○医用検査学研究方法論(2015)
○血液免疫病態学特論(2014)

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