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last modified：2025/04/02
Assistant Professor MUNESUE Seiichi
Faculty, Affiliation
Faculty of Medicine, Institute of Medical, Pharmaceutical and Health Sciences Biochemistry and Molecular Vascular Biology
Assistant Professor
College and School Educational Field
Division of Medical Sciences, Graduate School of Medical Science
Division of Medicine, Graduate School of Medical Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences
School of Medicine, College of Medical, Pharmaceutical and Health Sciences
School of Medicine, College of Medical, Pharmaceutical and Health Sciences
Laboratory
TEL:076-265-2181 FAX:076-234-4217
Academic Background
【Degree】
biotechnology
Career
Postdoctoral fellow Facul.of engineering, Kyoto Sangyo Univ Postdoctoral fellow(2002/04-2005/03)
assistant professor Facl. of engineering, Kyoto Sangyo Univ. assistant professor(2005/04-2007/03)
assistant professor Dept. of Molecular Vascular Biology(2007/04-)
Year & Month of Birth
1971/08
Academic Society
Award
Specialities
General medical chemistry
Speciality Keywords
Research Themes
Analysis of the mechanism of diabetes complecation development
Books
- HMGB1-RAGE系を標的とした抗腫瘍効果について 2018
- Munesue, S., Yoshitomi, Y., Kusano, Y., Koyama, Y., Nishiyama, A., Nakanishi, H., Miyazaki, K., Ishimaru, T., Miyaura, S., Okayama, M. and Oguri, K. A novel function of syndecan-2, suppression of MMP-2 activation, which causes suppression of metastasis. 282 28164-28174 2007
Papers
- Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice. Yamamoto Y, Liang M, Munesue S, Deguchi K, Harashima A, Furuhara K, Yuhi T, Zhong J, Akther S, Goto H, Eguchi Y, Kitao Y, Hori O, Shiraishi Y, Ozaki N, Shimizu Y, Kamide T, Yoshikawa A, Hayashi Y, Nakada M, Lopatina O, Gerasimenko M, Komleva Y, Malinovskaya N, Salmina AB, Asano M, Nishimori K, Shoelson SE, Yamamoto H, Higashida H. Commun Biol. 2 76 2019/02/25
- Transport of oxytocin to the brain after peripheral administration by membrane‐bound or soluble forms of receptors for advanced glycation end‐products Munesue S, Liang M, Harashima A, Zhong J, Furuhara K, Boitsova BE, Cherepanov MS, Gerasimenko M, Yuhi T, Yamamoto Y, Higashida H. J Neuroendocrinol. 2021/03
- Citrullinated Histone H3: Early Biomarker of Neutrophil Extracellular Traps in Septic Liver Damage. Nomura K, Miyashita T, Yamamoto Y, Munesue S, Harashima A, Takayama H, Fushida S, Ohta T. J Surg Res. 234 132-138. 2019
- CD38, CD157, and RAGE as Molecular Determinants for Social Behavior. Higashida H, Hashii M, Tanaka Y, Matsukawa S, Higuchi Y, Gabata R, Tsubomoto M, Seishima N, Teramachi M, Kamijima T, Hattori T, Hori O, Tsuji C, Cherepanov SM, Shabalova AA, Gerasimenko M, Minami K, Yokoyama S, Munesue SI, Harashima A, Yamamoto Y, Salmina AB, Lopatina O. Cells 9 1 2019
- Targeting RAGE: a viable strategy for cancer prevention and treatment? S Munesue, Y Yamamoto IMARS Highlights 2017/11/26
- Monitoring of Heat Shock Response and Phenotypic Changes in Hepatocellular Carcinoma After Heat Treatment. Zaimoku R, Miyashita T, Tajima H, Takamura H, Harashima AI, Munesue S, Yamamoto Y, Ninomiya I, Fushida S, Harada K. Anticancer Res. 39 10 5393-5401 2019
- In vitro anticancer effects of a RAGE inhibitor discovered using a structure-based drug design system Munesue S, El-Far AHAM, Harashima A, Sato A, Shindo M, Nakajima S, Inada M, Tanaka M, Takeuchi A, Tsuchiya H, Yamamoto H, Shaheen HME, El-Sayed YS, Kawano S, Tanuma SI, Yamamoto Y. Oncol Lett 15 4627-4634 2018/04/15
- Soluble Thrombomodulin Attenuates Endothelial Cell Damage in Hepatic Sinusoidal Obstruction Syndrome. Takada S, Miyashita T, Yamamoto Y, Kanou S, Munesue S, Ohbatake Y, Nakanuma S, Okamoto K, Sakai S, Kinoshita J, Makino I, Nakamura K, Tajima H, Takamura H, Ninomiya I, Fushida S, Ohta T. In Vivo. 32 6 1409-1417 2018
- Contribution of methylglyoxal to delayed healing of bone injury in diabetes. Aikawa T, Matsubara H, Ugaji S, Shirakawa J, Nagai R, Munesue S, Harashima A, Yamamoto Y, Tsuchiya H. Mol Med Rep 16 1 403-409 2017
- Anti-tumor effects of a nonsteroidal anti-inflammatory drug zaltoprofen on chondrosarcoma via activating peroxisome proliferator-activated receptor gamma and suppressing matrix metalloproteinase-2 expression. Higuchi T, Takeuchi A, Munesue S, Yamamoto N, Hayashi K, Kimura H, Miwa S, Inatani H, Shimozaki S, Kato T, Aoki Y, Abe K, Taniguchi Y, Aiba H, Murakami H, Harashima A, Yamamoto Y, Tsuchiya H. Cancer Med. 7 5 1944-1954 2018
- Endogenous secretory receptor for advanced glycation end-products inhibits amyloid-beta1-42 uptake into mouse brain. J Alzheimer’s Dis 28 3 409-420 2012/11
- Intestinal transepithelial permeability of oxytocin into the blood is dependent on the receptor for advanced glycation end products in mice. Higashida H, Furuhara K, Yamauchi AM, Deguchi K, Harashima A, Munesue S, Lopatina O, Gerasimenko M, Salmina AB, Zhang JS, Kodama H, Kuroda H, Tsuji C, Suto S, Yamamoto H, Yamamoto Y. Sci Rep. 7 1 7883 2017
- Preventive Effect of Salicylate and Pyridoxamine on Diabetic Nephropathy. Abouzed TK, Munesue S, Harashima A, Masuo Y, Kato Y, Khailo K, Yamamoto H, Yamamoto Y. J Diabetes Res. 1786789 2016
- Tumor-associated macrophages of the M2 phenotype contribute to progression in gastric cancer with peritoneal dissemination. Yamaguchi T, Fushida S, Yamamoto Y, Tsukada T, Kinoshita J, Oyama K, Miyashita T, Tajima H, Ninomiya I, Munesue S, Harashima A, Harada S, Yamamoto H, Ohta T. Gastric Cancer 19 1052-1065 2016
- Induction of receptor for advanced glycation end-products by insufficient leptin action triggers pancreatic β-cell failure in type 2 diabetes. Genes to Cells 2013/01
- Low-molecular weight heparin suppresses RAGE-mediated expression of the malignant phenotype in human fibrosarcoma cells. Cancer science 104 6 740-749 2013/06
- Septic shock is associated with receptor for advanced glycation endproducts (RAGE) ligation of LPS. JOURNAL OF IMMUNOLOGY 186 5 3248-3257 2011/01
- Regulation of RAGE for Attenuating Progression of Diabetic Vascular Complications. Exp Diabetes Res 2012/11
- Maltitol endows foods with lower 3-deoxyglucosone content and less RAGE agonism as a sweetener against sucrose. Kuretani A, Kawamura R, Munesue S, Yamamoto Y, Honda J, Yamamoto H. Glycative Stress Res, 1 25-31
- cAMP ameliorates inflammation by modulation of macrophage receptor for advanced glycation end-products. Motoyoshi S, Yamamoto Y, Munesue S, Igawa H, Harashima A, Saito H, Han D, Watanabe T, Sato H, Yamamoto H. Biochem J 463 75-82 2014
- Septic Shock Is Associated with Receptor for Advanced Glycation End Products Ligation of LPS Yamamoto, Yasuhiko;Harashima, Ai;Saito, Hidehito;Tsuneyama, Koichi;Munesue, Seiichi;Motoyoshi, So;Han, Dong;Watanabe, Takuo;Asano, Masahide;Takasawa, Shin;Okamoto, Hiroshi;Shimura, Satoshi;Karasawa, Tadahiro;Yonekura, Hideto;Yamamoto, Hiroshi JOURNAL OF IMMUNOLOGY 186 5 3248-3257 2011
- Pancreatic beta cell dysfunction in diabetes through induction of RAGE expression Han, Dong;Yamamoto, Yasuhiko;Munesue, Seiichi;Motoyoshi, Soh;Saito, Hidehito;Watanabe, Takuo;Yamamoto, Hiroshi AMINO ACIDS 41 0 S31-S31 2011
- Inhibitory effects of food-derived components on AGE-RAGE signaling Munesue, Seiichi;Yamamoto, Yasuhiko;Motoyoshi, So;Hidehito, Saito;Watanabe, Takuo;Yamamoto, Hiroshi AMINO ACIDS 41 0 S55-S55 2011
- Inhibition of Allergic Bronchial Asthma by Thrombomodulin Is Mediated by Dendritic Cells Takagi, Takehiro;Taguchi, Osamu;Toda, Masaaki;Ruiz, Daniel Boveda;Bernabe, Paloma Gil;D'Alessandro-Gabazza, Corina N.;Miyake, Yasushi;Kobayashi, Tetsu;Aoki, Shinya;Chiba, Fumiko;Yano, Yutaka;Conway, Edward M.;Munesue, Seiichi;Yamamoto, Yasuhiko;Yamamoto, Hiroshi;Suzuki, Koji;Takei, Yoshiyuki;Morser, John;Gabazza, Esteban C. AMERICAN JOURNAL OF RESPIRATORY AND CRITICAL CARE MEDICINE 183 1 31-42 2011
- Sivelestat sodium hydrate inhibits neutrophil migration to the vessel wall and suppresses hepatic ischemia-reperfusion injury Sakai, Seisho; Tajima, Hidehiro; Miyashita, Tomoharu; Nakanuma, Shinichi Ichi; Makino, Isamu; Hayashi, Hironori; Nakagawara, Hisatoshi; Kitagawa, Hirohisa; Fushida, Sachio; Fujimura, Takashi; Saito, Hidehito; Munesue, Seiichi; Yamamoto, Yasuhiko; Ohta, Tetsuo Digestive Diseases and Sciences 59 4 787-794 2014/01/01
- Induction of receptor for advanced glycation end products by insufficient leptin action triggers pancreatic β-cell failure in type 2 diabetes Han, Dong; Yamamoto, Yasuhiko; Munesue, Seiichi; Motoyoshi, So; Saito, Hidehito; Win, Myat Thu Thu; Watanabe, Takuo; Tsuneyama, Koichi; Yamamoto, Hiroshi Genes to Cells 18 4 302-314 2013/04/01
- Validated liquid culture monitoring system for lifespan extension of Caenorhabditis elegans through genetic and dietary manipulations Win, Myat Thu Thu; Yamamoto, Yasuhiko; Munesue, Seiichi; Han, Dong; Harada, Shinichi; Yamamoto, Hiroshi Aging and Disease 4 4 178-185 2013/01/01
- Thrombomodulin modulates dendritic cells via both antagonism of high mobility group protein B1 and an independent mechanism Toda, Masaaki; D'Alessandro-Gabazza, Corina Nayade; Takagi, Takehiro; Chelakkot-Govindalayathila, Ayshwarya Lakshmi; Taguchi, Osamu; Roeen, Ziaurahman; Munesue, Seiichi; Yamamoto, Yasuhiko; Yamamoto, Hiroshi; Gabazza, Esteban Cesar; Morser, John Allergology International 63 1 57-66 2014/03/17
- Low-molecular weight fractions of Japanese soy sauce act as a RAGE antagonist via inhibition of RAGE trafficking to lipid rafts Munesue, Seiichi; Yamamoto, Yasuhiko; Urushihara, Ryouta; Inomata, Kouhei; Saito, Hidehito; Motoyoshi, So; Watanabe, Takuo; Yonekura, Hideto; Yamamoto, Hiroshi Food and Function 4 12 1835-1842 2013/12/01
- Regulation of RAGE for attenuating progression of diabetic vascular complications Win, Myat Thu Thu; Yamamoto, Yasuhiko; Munesue, Seiichi; Saito, Hidehito; Han, Dong; Motoyoshi, So; Kamal, Tarek; Ohara, Takuro; Watanabe, Takuo; Yamamoto, Hiroshi Experimental Diabetes Research 2012 2012/01/03
- Low molecular weight heparin suppresses receptor for advanced glycation end products-mediated expression of malignant phenotype in human fibrosarcoma cells Takeuchi, Akihiko; Yamamoto, Yasuhiko; Munesue, Seiichi; Harashima, Ai; Watanabe, Takuo; Yonekura, Hideto; Yamamoto, Hiroshi; Tsuchiya, Hiroyuki Cancer Science 104 6 740-749 2013/06/01
- RAGE mediates vascular injury and inflammation after global cerebral ischemia Kamide, Tomoya; Kitao, Yasuko; Takeichi, Toshiaki; Okada, Akiko; Mohri, Hiromi; Schmidt, Ann Marie; Kawano, Takayuki; Munesue, Seiichi; Yamamoto, Yasuhiko; Yamamoto, Hiroshi; Hamada, Junichiro; Hori, Osamu Neurochemistry International 60 3 220-228 2012/02/01
- Inhibitory Effects of Saururus chinensis Extract on Receptor for Advanced Glycation End-Products-Dependent Inflammation and Diabetes-Induced Dysregulation of Vasodilation. Kenjiro Hayashi,Koichi Sato,Seishi Ochi,Shuhei Kawano,Seiichi Munesue,Ai Harashima,Yu Oshima,Kumi Kimura,Takashi Kyoi,Yasuhiko Yamamoto International journal of molecular sciences 23 10 2022/05/20
- Glycation reaction and the role of the receptor for advanced glycation end-products in immunity and social behavior. Nontaphat Leerach,Ai Harashima,Seiichi Munesue,Kumi Kimura,Yu Oshima,Hisanori Goto,Hiroshi Yamamoto,Haruhiro Higashida,Yasuhiko Yamamoto Glycoconjugate journal 38 3 303 2021/06
- Dynamic switch of immunity and antitumor effects of metformin in rat spontaneous esophageal carcinogenesis. Ryohei Takei,Tomoharu Miyashita,Satoshi Takada,Hidehiro Tajima,Itasu Ninomiya,Hiroyuki Takamura,Sachio Fushida,Ai Harashima,Seiichi Munesue,Shintaro Yagi,Noriyuki Inaki,Tetsuo Ohta,Yasuhiko Yamamoto Cancer immunology, immunotherapy : CII 71 4 777 2021/08/16
- Soluble receptor for advanced glycation end products protects from ischemia- and reperfusion-induced acute kidney injury. Taro Miyagawa,Yasunori Iwata,Megumi Oshima,Hisayuki Ogura,Koichi Sato,Shiori Nakagawa,Yuta Yamamura,Yasutaka Kamikawa,Taito Miyake,Shinji Kitajima,Tadashi Toyama,Akinori Hara,Norihiko Sakai,Miho Shimizu,Kengo Furuichi,Seiichi Munesue,Yasuhiko Yamamoto,Shuichi Kaneko,Takashi Wada Biology open 11 1 2022/01/15
- Thrombopoietin accumulation in hepatocytes induces a decrease in its serum levels in a sinusoidal obstruction syndrome model. Hiroto Yamazaki,Hidehiro Tajima,Yasuhiko Yamamoto,Seiichi Munesue,Mitsuyoshi Okazaki,Yoshinao Ohbatake,Shinichi Nakanuma,Isamu Makino,Tomoharu Miyashita,Hiroyuki Takamura,Tetsuo Ohta Molecular medicine reports 25 6 2022/06
- Receptor for advanced glycation end-products (RAGE) plays a critical role in retrieval behavior of mother mice at early postpartum. Maria Gerasimenko,Olga Lopatina,Seiichi Munesue,Ai Harashima,Shigeru Yokoyama,Yasuhiko Yamamoto,Haruhiro Higashida Physiology & behavior 235 113395 2021/06/01
- RAGE signaling antagonist suppresses mouse macrophage foam cell formation. Nontaphat Leerach,Seiichi Munesue,Ai Harashima,Kumi Kimura,Yu Oshima,Shuhei Kawano,Mariko Tanaka,Akane Niimura,Natthiya Sakulsak,Hiroshi Yamamoto,Osamu Hori,Yasuhiko Yamamoto Biochemical and biophysical research communications 555 74 2021/05/28
- A nonsteroidal anti-inflammatory drug, zaltoprofen, inhibits the growth of extraskeletal chondrosarcoma cells by inducing PPARγ, p21, p27, and p53 Takashi Higuchi,Akihiko Takeuchi,Seiichi Munesue,Norio Yamamoto,Katsuhiro Hayashi,Ai Harashima,Yasuhiko Yamamoto,Hiroyuki Tsuchiya Cell Cycle 22 8 1 2023/01/12
- Hypoxia-Induced CD36 Expression in Gastric Cancer Cells Promotes Peritoneal Metastasis via Fatty Acid Uptake. Tatsuya Aoki,Jun Kinoshita,Seiichi Munesue,Toshihide Hamabe-Horiike,Takahisa Yamaguchi,Yusuke Nakamura,Koichi Okamoto,Hideki Moriyama,Keishi Nakamura,Shinichi Harada,Yasuhiko Yamamoto,Noriyuki Inaki,Sachio Fushida Annals of surgical oncology 2022/08/30
- Dual Nature of RAGE in Host Reaction and Nurturing the Mother-Infant Bond. Yu Oshima,Ai Harashima,Seiichi Munesue,Kumi Kimura,Nontaphat Leerach,Hisanori Goto,Mariko Tanaka,Akane Niimura,Kenjiro Hayashi,Hiroshi Yamamoto,Haruhiro Higashida,Yasuhiko Yamamoto International journal of molecular sciences 23 4 2022/02/14
- Correction to: Dynamic switch of immunity and antitumor effects of metformin in rat spontaneous esophageal carcinogenesis. Ryohei Takei,Tomoharu Miyashita,Satoshi Takada,Hidehiro Tajima,Itasu Ninomiya,Hiroyuki Takamura,Sachio Fushida,Ai Harashima,Seiichi Munesue,Shintaro Yagi,Noriyuki Inaki,Tetsuo Ohta,Yasuhiko Yamamoto Cancer immunology, immunotherapy : CII 71 4 791 2021/09/07
- Oxytocin Dynamics in the Body and Brain Regulated by the Receptor for Advanced Glycation End-Products, CD38, CD157, and Nicotinamide Riboside Haruhiro Higashida,Kazumi Furuhara,Olga Lopatina,Maria Gerasimenko,Osamu Hori,Tsuyoshi Hattori,Yasuhiko Hayashi,Stanislav M. Cherepanov,Anna A. Shabalova,Alla B. Salmina,Kana Minami,Teruko Yuhi,Chiharu Tsuji,PinYue Fu,Zhongyu Liu,Shuxin Luo,Anpei Zhang,Shigeru Yokoyama,Satoshi Shuto,Mizuki Watanabe,Koichi Fujiwara,Sei-ichi Munesue,Ai Harashima,Yasuhiko Yamamoto Frontiers in Neuroscience 16 2022/07/07
- Use of Cocultures to Measure the Blood-Brain Barrier Permeability of Oxytocin. Yasuhiko Yamamoto,Ai Harashima,Sei-Ichi Munesue,Haruhiro Higashida Methods in molecular biology (Clifton, N.J.) 2384 247 2022
- ASO Visual Abstract: Hypoxia-Induced CD36 Expression in Gastric Cancer Cells Promotes Peritoneal Metastasis via Fatty Acid Uptake. Tatsuya Aoki,Jun Kinoshita,Seiichi Munesue,Toshihide Hamabe-Horiike,Takahisa Yamaguchi,Yusuke Nakamura,Koichi Okamoto,Hideki Moriyama,Keishi Nakamura,Shinichi Harada,Yasuhiko Yamamoto,Noriyuki Inaki,Sachio Fushida Annals of surgical oncology 2023/02/15
- Assaying ADAMTS13 Activity as a Potential Prognostic Biomarker for Sinusoidal Obstruction Syndrome in Mice. Masakazu Saeki,Seiichi Munesue,Yuri Higashi,Ai Harashima,Ryohei Takei,Satoshi Takada,Shinichi Nakanuma,Tetsuo Ohta,Shintaro Yagi,Hidehiro Tajima,Yasuhiko Yamamoto International journal of molecular sciences 24 22 2023/11/15
- Cilostazol improves the prognosis after hepatectomy in rats with sinusoidal obstruction syndrome. Hiroaki Sugita,Shinichi Nakanuma,Seiichi Munesue,Tatsuya Ishikawa,Tomokazu Tokoro,Ryohei Takei,Mitsuyoshi Okazaki,Kaichiro Kato,Satoshi Takada,Isamu Makino,Noriyuki Ozaki,Yasuhiko Yamamoto,Shintaro Yagi Journal of gastroenterology and hepatology 2024/02/13
Conference Presentations
- Exploring essential RAGE domain to induce spheroid formation using human osteosarcoma HOS cells(2023/10/12)
- In vitro anticancer effects of a novel RAGE inhibitor on suppression of tumor malignant phenotypes in human fibrosarcoma cells(conference：13th International Symposium on the Maillard Reaction)(2018/09/10)
- Molecular identification of RAGE-mediated tumor malignancy in human osteosarcoma HOS cells.(2023/10/12)
- Drug library screening to identify new compounds for inducing ectodomain shedding of RAGE and formation of soluble RAGE(conference：13th International Symposium on the Maillard Reaction)(2018/09/10)
- Preventive effects of salicylate and pyridoxamine on the development of diabetic kidney injuries.(2017/12/06)
- In vitro effects of a novel RAGE inhibitor on tumor malignancy in human fibrosarcoma HT1080 cells(2017/12/06)
- Neuroprotective effects of endogenous secretory rage in ischemic cerebrovasculr diseases.(conference：12th International Symposium on the Maillard Reaction )(2015/09)
- Insufficient leptin action induces RAGE expression and triggers pancreatic beta-cell failure type 2 diabetes. (conference：12th International Symposium on the Maillard Reaction )(2015/09)
- Absence of mature adipocytes and adipocyte precursor cells in mesentery of Suncus murinus.(conference：American Diabetes Association 73rd scientific session)(2013/06)
Others
- Zaltoprofenはin vitroとin vivoにおいてPPARγを介して軟骨肉腫の増殖を抑制する 樋口 貴史,山本 憲男,林 克洋,武内 章彦,阿部 健作,谷口 裕太,原島 愛,棟居 聖一,山本 靖彦,土屋 弘行 日本整形外科学会雑誌 91 8 S1527 2017/08
- ZaltoprofenはPPARγ(peroxisome proliferator-activated receptor γ)を介して軟骨肉腫における浸潤能および遊走能の抑制効果を発揮する 樋口 貴史,武内 章彦,山本 憲男,林 克洋,三輪 真嗣,稲谷 弘幸,阿部 健作,谷口 裕太,棟居 聖一,山本 靖彦,土屋 弘行 日本整形外科学会雑誌 90 8 S1556 2016/08
- ZaltoprofenはPPARγを介して軟骨肉腫の増殖を抑制する 樋口 貴史,山本 憲男,林 克洋,武内 章彦,阿部 健作,谷口 裕太,相羽 久輝,荒木 麗博,原島 愛,棟居 聖一,山本 靖彦,土屋 弘行 日本癌治療学会学術集会抄録集 55回 P41 2017/10
- 整形トピックス ザルトプロフェンはPPARγを介して軟骨肉腫における浸潤能および遊走能の抑制効果を発揮する 樋口 貴史,武内 章彦,土屋 弘行,山本 靖彦,棟居 聖一 整形外科 68 10 1082 2017/09
- 糖尿病による骨修復能障害はピリドキサミン投与により改善される 宇賀治 修平,松原 秀憲,相川 敬男,吉田 泰久,棟居 聖一,原島 愛,山本 靖彦,土屋 弘行 日本整形外科学会雑誌 91 8 S1703 2017/08
- 骨軟部 化学療法・有害事象の現況 軟骨肉腫においてzaltoprofenはPPARγを介して抗腫瘍効果を発揮する 樋口 貴史,武内 章彦,山本 憲男,林 克洋,阿部 健作,谷口 裕太,相羽 久輝,棟居 聖一,山本 靖彦,土屋 弘行 日本癌治療学会学術集会抄録集 54回 WS31 2016/10
- 軟骨肉腫に対するzaltoprofenのPPARγ(peroxisome proliferator-activated receptor γ)を介した抗腫瘍効果の解析 樋口 貴史,山本 憲男,林 克洋,武内 章彦,阿部 健作,谷口 裕太,相羽 久輝,村上 英樹,棟居 聖一,山本 靖彦,土屋 弘行 日本整形外科学会雑誌 91 6 S1393 2017/06
Arts and Fieldwork
Patent
Theme to the desired joint research
Grant-in-Aid for Scientific Research
○「RAGE膜貫通ドメインと結合する分子の発見とがん細胞悪性化機構の解明」(2023-2025)
○「バイオプリンティング技術を用いた新規3次元皮膚モデル作製への挑戦」(2023-2025)
○「愛情ホルモン・オキシトシンによる炎症免疫抑制作用の分子基盤の解明」(2021-2023)
○「RAGE膜貫通ドメインによる細胞膜ダイナミクスとがん悪性化シグナルの解明」(2020-2022)
○「オキシトシンの血液脳関門移行に関わる分子装置の解明と愛情の構築研究」(2018-2020)
○「Glyoxalase2遺伝子多型に基づく統合失調症の病態解明と新規治療薬の創出」(2018-2020)
○「食品に含まれるRAGEシグナル阻害成分の同定と阻害機構の解明」(2014-2016)
○「新規内在性デコイ受容体ｅｓＲＡＧＥに着目したアルツハイマー病予防・治療法の開発」
○「新規内在性デコイ受容体に着目したアルツハイマー病の病因・制御の解明」
Competitive research funding,Contribution
Collaborative research,Consignment study
Classes (Bachelors)
○Introduction to Region-studies(2022)
○Basic Medical and Pharmaceutical Sciences Rotation Practice（Course in Biomedical Science）ⅠＡ(2022)
○Basic Medical and Pharmaceutical Sciences Rotation Practice（Course in Biomedical Science）ⅠＡ(2022)
○Biochemistry 2(2022)
○Biochemistry 4(2022)
○Academic Skills(2022)
○Basic Medical and Pharmaceutical Sciences Rotation Practice（Course in Biomedical Science）ⅠＡ(2022)
○Biochemistry 2(2022)
○Basic Medical and Pharmaceutical Sciences Rotation Practice（Course in Biomedical Science）ⅠＡ(2022)
○Basic Biological Chemistry(2022)
○Introduction to Region-studies(2021)
○Academic Skills(2021)
○Biochemistry 2(2020)
○Biochemistry2(2019)
○Biochemistry2(2017)
○Biochemistry2(2017)
Classes (Graduate Schools)
○Molecular Biology of the Cardiovascular System(2020)
○Molecular Biology of the Cardiovascular System(2020)
○Molecular Biology of the Cardiovascular System(2019)
○Molecular Biology of the Cardiovascular System(2019)
○Molecular Biology of the Cardiovascular System(2018)
○Molecular Biology of the Cardiovascular System(2018)
○Molecular Biology of the Cardiovascular System(2017)
○Molecular Biology of the Cardiovascular System(2017)