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Researcher Information

last modified:2022/08/15

Professor MATSUMOTO Kunio

Mail Laboratory Website

Faculty, Affiliation

Cancer Research Institute
Professor, Cancer Research Institute
教授

College and School Educational Field

Division of Medical Sciences, Graduate School of Medical Science
Division of Natural Sciences, Graduate School of Natural Science and Technology
Division of Medical Science, Graduate School of Medical Science
Division of Natural System, Graduate School of Natural Science and Technology
Course in Biosystems, School of Biological Science and Technology, College of Science and Engineering

Laboratory

Division of Tumor Dynamics and Regulation TEL:076-264-6745 FAX:076-234-4513

Academic Background

【Academic background(Doctoral/Master's Degree)】
Osaka University Doctor Graduate School, Division of Natural Science Biochemistry 198603 Completed
【Academic background(Bachelor's Degree)】
Kanazawa University Biology 198103
【Degree】
Ph.D.

Career

Assistant Professor School of Medicine, Osaka University Assistant Professor(1986/12/16-1990/05/31)
Assistant Professor Faculty of Science, Kyushu University Assistant Professor(1990/06/01-1993/03/31)
Assistant Professor School of Medicine, Osaka University Assistant Professor(1993/06/01-1994/03/31)
Assistant Professor School of Medicine, Osaka University Assistant Professor(1994/04/01-1996/03/31)
Associate Professor School of Medicine, Osaka University Associate Professor(1996/04/01-2001/03/31)
Visiting Associate Professor Brawn University Visiting Associate Professor(1998/08/01-1999/05/31)
Associate Professor Osaka Univ. Graduate School of Medicine Associate Professor(2001/04/01-2007/03/31)
Professor Kanazawa Univ. Cancer Research Institute(2007/04/01-)

Year & Month of Birth

1959/02

Academic Society

Award

○科研費審査委員表彰(2016/09/30)
○The Commendation for Science and Technology by MEXT (the Minister of Education, 
Culture, Sports, Science and Technology), Prizes for Science and Technology(2014/04/15)
○Nature Medicine-AnGes MG BioMedical Award (Main Award)(2006/05/29)
○The 3rd Biobusiness Competition Japan Special Award by an Examining Comittee(2002/12/12)
○The Most Valuable Article Award for 30 Anniversary Memorial of Nikkei Science Journal(2001/10/06)
○Kudo Foundation Award(1999)
○JB Award from the Japanese Biochemical Society(1996/08/27)
○Incitement Award of the Japanese Cancer Association(1997/09/27)
○Academic Incitement Award of Japanese Industrial Hygiene Dermatology Association(1991/05/31)

Specialities

Tumor biology、General medical chemistry

Speciality Keywords

Synthetic HGF,Macrocyclic peptide,Tumor microenvironment,MET,Metastasis,Growth Factor

Research Themes

Tissue regeneration mediated by HGF-MET. Regulation and drug discovery targeting HGF-MET by macrocyclic peptide technology. HiP-8.

Tissue regeneration mediated by HGF-Met. Therapeutic application of HGF. Anti-cancer approach with NK4.

Books

  •  Matsumoto, K. and Nakamura, T Pleiotropic roles of HGF as a pleiotropic factor in mitogenesis, morphogenesis, and organ regeneration CRC Press and Gakkai Shuppan Center 1994
  •  Matsumoto, K. and Nakamura, T HGF-c-Met receptor pathway in tumor invasion-metastasis and potential cancer treatment with NK4 Kluwer Academic Publisher 2001
  •  Matsuo, Y., Nishi, N., Matsumoto, K., Miyazaki, K., Suzuki, F., and Nishikawa, K 3-[(3-Cholamidopropyl)dimethylammonio]-1-propane sulfonate as anon-cytotoxic stabilizing agent for growth factors Academic Press, Inc 1991
  •  Matsumoto, K. and Nakamura, T Role of hepatocyte growth factor in liver regeneration Inserm/Eurotext 1992
  •  Hashimoto, K., Matsumoto, K., and Yoshikawa, K The effect of vitamin D3 on human keratinocytes and its metabolism Elsevier Science Publishers 1992

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  •  Matsumoto, K. and Nakamura, T Roles of HGF as a pleiotropic factor in organ regeneration Birkhauser Verlag 1993
  •  Nakamura, T., Mizuno, K. and Matsumot Hepatocyte growth factor: mitogen, motogen, morphogen, and its roles in tissue regeneration Elsevier 1993
  •  Matsumoto, K. and Nakamura, T Structure, pleiotropic actions, and organotrophic roles of hepatocyte growth factor Springer-Verlag 1994
  •  Matsumoto, K. and Nakamura, T Hepatotrohpic and renotrophic activities of HGF in vivo: possible application of HGF for hepatic and renal diseases Springer-Verlag 1994
  •  Matsumoto, K. and Nakamura, T HGF as a potent renotrophic factor and its therapeutic potential for acute renal failure Churchill Livingstone 1995
  •  Amaike, H., Matsumoto, K., and Nakamura, T Hepatocyte growth factor: pleiotrophic roles for liver regeneration and possible clinical applications Elsevier Science 1995
  •  Matsumoto, K. and Nakamura, T Collagenase and Hyaluronidase John & Wiley 12B 1995
  •  Koshimizu, U., Matsumoto, K., and Nakamura, T Hepatotrophic activities of HGF in liver regeneration after injury and the clinical potentiality for liver diseases Narosa-Springer Verlag 1997
  •  Matsumoto, K. and Nakamura, T HGF: its organotrophic role and therapeutic potential John Willey & Sons 1997
  •  Matsumoto, K. and Nakamura, T Hepatocyte growth factor for tissue organization and its therapeutic application Elseviier Science 1998
  •  Matsumoto, K. and Nakamura, T Hepatocyte growth factor and Met in tumour invasion-metastasis: from mechanisms to cancer prevention Kluwer Academic Publishers 2000
  •  Matsumoto, K. and Nakamura, T Hepatocyte growth factor Academic Press, San Diego 2004
  •  Matsumoto, K. and Nakamura, T.  NK4 gene therapy targeting HGF-Met and angiogenesis. Medical View 22-33 2007/06
  •  Significance, mechanisms, and progress of anticancer drugs targeting HGF-Met.  InTech Open Access Publisher 2011/06
  •  Nakade J, Takeuchi S, Nakagawa T, Ishikawa D, Sano T, Nanjo S, Yamada T, Ebi H, Zhao L, Yasumoto K, Matsumoto K, Yonekura K, Yano S Triple inhibition of EGFR, Met, and VEGF suppresses regrowth of HGF-triggered, erlotinib-resistant lung cancer harboring an EGFR mutation 9 775-783 2014

Papers

Conference Presentations

Others

  •  Hepatocyte growth factor: molecular structure and implications for a central role in liver regeneration Matsumoto, K. and Nakamura, T 6 1991
  •  Hepatocyte growth factor: molecular structure, roles in liver regeneration, and other biological functions Matsumoto, K., and Nakamura, T 3 1992
  •  Emerging multipotent aspects of hepatocyte growth factor Matsumoto, K., and Nakamura, T 119 1996
  •  HGF in lung morphogenesis and tumor invasion: roles as a mediator in epithelial-mesenchymal and tumor-stromal interactions Matsumoto, K., Date, K., Ohmichi, H. and Nakamura, T 38 1996
  •  Hepatocyte growth factor (HGF) as tissue organizer for organogenesis and regeneration Matsumoto, K., and Nakamura, T 239 1997

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  •  Hepatocyte growth factor and Met: molecular dialogue for tissue organization and repair Matsumoto, K., and Nakamura, T 2 1998
  •  Hepatocyte growth factor/scatter factor, its molecular, cellular and clinical implications in cancer Jiang, W. G., Hiscox, S., Matsumoto, K., and Nakamura, T 29 1999
  •  Hepatocyte growth factor in renal regeneration, renal disease, and potential therapeutics Matsumoto, K., Mizuno, S., and Nakamura, T 9 2000
  •  Hepatocyte growth factor: renotropic role and potential therapeutics for renal diseases Matsumoto, K., and Nakamura, T 59 2001
  •  NK4 (HGF-antagonist and angiogenesis inhibitor) in cancer biology and therapeutics Matsumoto, K., and Nakamura, T 94 2003
  •  Hepatocyte growth factor, its receptor, and their potential value in cancer therapies Jiang, W. G., Martin, T. A., Parr, C., Davies, G., Matsumoto, K., and Nakamura, T 53 2005
  •  Angiogenesis Inhibitors: From Laboratory to Clinical Application Nakamura, T. and Matsumoto, K 333 2005
  •  Mechanisms and significance of bifunctional NK4 in cancer treatment Matsumoto, K. and Nakamura, T 333 2005
  •  Hepatocyte growth factor and the Met system as a mediator of tumor-stromal interactions Matsumoto, K. and Nakamura, T 119 2006
  •  Different reactivities of enzyme-linked immunosorbent assays for hepatocyte growth factor. Fukuta, K., Adachi, E., Matsumoto, K., and Nakamura, T 402 42-46 2009
  •  Characterization of the enhancing effect of protamine on the proliferative activity of hepatocyte growth factor in rat hepatocytes. Liu KX, Kato Y, Matsumoto K, Nakamura T, Kaku T, Sugiyama Y 26 1012-1021 2009
  •  Hepatocyte growth factor: molecular structure and implications for a central role in liver regeneration Matsumoto, K. and Nakamura, T 6 509-519 1991
  •  Hepatocyte growth factor: molecular structure, roles in liver regeneration, and other biological functions. Matsumoto, K., and Nakamura, T. 3 27-54 1992
  •  Emerging multipotent aspects of hepatocyte growth factor. 119 591-600 1996
  •  HGF in lung morphogenesis and tumor invasion: roles as a mediator in epithelial-mesenchymal and tumor-stromal interactions. Matsumoto, K., Date, K., Ohmichi, H. and Nakamura, T. 1996
  •  Hepatocyte growth factor (HGF) as tissue organizer for organogenesis and regeneration. Matsumoto, K., and Nakamura, T 239 639-644 1997
  •  Hepatocyte growth factor and Met: molecular dialogue for tissue organization and repair. Matsumoto, K., and Nakamura, T. 2 1-8 1998
  •  Hepatocyte growth factor/scatter factor, its molecular, cellular and clinical implications in cancer. Jiang, W. G., Hiscox, S., Matsumoto, K., and Nakamura, T 29 209-248 1999
  •  Hepatocyte growth factor in renal regeneration, renal disease, and potential therapeutics. 9 395-402 2000
  •  Hepatocyte growth factor: renotropic role and potential therapeutics for renal diseases. Matsumoto, K., and Nakamura, T 59 2023-2038 2001
  •  NK4 (HGF-antagonist and angiogenesis inhibitor) in cancer biology and therapeutics. Matsumoto, K., and Nakamura, T 94 321-327 2003
  •  Hepatocyte growth factor, its receptor, and their potential value in cancer therapies. Jiang, W. G., Martin, T. A., Parr, C., Davies, G., Matsumoto, K., and Nakamura, T 53 35-69 2005
  •  Angiogenesis Inhibitors: From Laboratory to Clinical Application. Nakamura, T. and Matsumoto, K. 333 289-291 2005
  •  Mechanisms and significance of bifunctional NK4 in cancer treatment. Matsumoto, K. and Nakamura, T 333 316-327 2005
  •  Hepatocyte growth factor and the Met system as a mediator of tumor-stromal interactions. Matsumoto, K. and Nakamura, T 119 477-483 2006
  •  NK4 gene therapy targeting HGF-Met and angiogenesis. Matsumoto, K., and Nakamura, T 13 1943-1951 2008
  •  The functions and possible significance of Kremen as the gatekeeper of Wnt signaling in development and pathology. Nakamura, T., Nakamura, T. and Matsumoto, K 12 391-408 2008
  •  Hepatocyte growth factor gene therapy for hypertension. Komamura, K., Miyazaki, J., Imai, E., Matsumoto, K., Nakamura, T. 423 393-404 2008
  •  Hepatocyte growth factor as a renotrophic and anti-fibrotic regulator in chronic renal disease. Mizuno, S., Matsumoto, K., and Nakamura, T. 13 7072-7086 2008
  •  Hepatocyte Growth Factor and Met in Tumor Biology and Therapeutic Approach with NK4. Matsumoto, K., Nakamura, T., Sakai, K., and Nakamura, T. 8 3360-3370 2008

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「超機能バイオロジクスリガンドの創成と検証の研究」(2021-2023) 
○「次世代がん医療創生研究事業(P-CREATE) 「イメージング活用創薬の視点からの異分野技術融合によるシームレスな薬効評価システムの構築と実施」」(2016-2021) 
○「高機能環状ペプチド分子技術と融合する転移・薬剤耐性のがん微小環境の研究」(2019-2021) 
○「ヘテロ受容体カップリングのシグナル特性と人工リガンド創成の研究」(2015-2016) 
○「3-D浸潤性獲得と上皮形態形成制御を基盤とする腫瘍悪性化機構の研究」(2012-2014) 
○「Met/HGF受容体シグナル伝達能のON-OFF制御を介した組織再生制御の研究」(2008-2010) 

Competitive research funding,Contribution

Collaborative research,Consignment study

○Therapeutic approach with HGF and NK4(2007-2023)
○医工融合による動脈硬化の診断と治療の先導的研究/血管病変部位の治療(2011-2012)
○Role of HGF in pharmaceutical actions of PGs in tissue regeneration(2008-2012)

Classes (Bachelors)

Classes (Graduate Schools)

○Tumor Biochemistry(2017)
○Cancer molecular pathology 2(2017)
○Cancer molecular pathology 2(2017)
○Cancer molecular pathology 2(2017)
○Molecular Oncology(2017)
○Tumor Biology(2017)
○Tumor Biology(2017)
○Cancer molecular pathology 2(2017)
○Biology of Cancer 2B(2017)
○Biology of Cancer 2A(2017)
○Medical Sciences(2016)
○Tumor Biochemistry(2016)
○Tumor Biology(2016)
○Tumor Biology(2016)
○Biology of Cancer 2B(2016)
○Biology of Cancer 2A(2016)
○Cancer molecular pathology 2(2016)
○Molecular Oncology(2016)

International Project

International Students

Lecture themes

Others (Social Activities)

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