Specialities

Speciality Keywords

Single molecule observation, Atomic force microscopy

Research Themes

Books

• 　Watanabe-Nakayama T, Machida S, Saito M, Afrin R, Ikai A.　Cells, Forces, and the Microenvironment　CRC Press　2015/03/02
• 　Ikai A, Afrin R, Watanabe-Nakayama T, Machida S.　Atomic Force Microscopy in Liquid: Biological Applications　Wiley Online Library　2012/04/10

Papers

• 　A cationic polymethacrylate-copolymer acts as an agonist for β-amyloid and an antagonist for amylin fibrillation　Sahoo BR, Genjo T, Watanabe-Nakayama T, Stoddard AK, Ando T, Yasuhara K, Fierkead CA, Ramamoorthy A　Chem Sci　10　3976-3986　2019
• 　High molecular weight amyloid β1-42 oligomers induce neurotoxicity via plasma membrane damage.　Yasumoto T, Takamura Y, Tsuji M, Watanabe-Nakayama T, Imamura K, Inoue H, Nakamura S, Inoue T, Kimura A, Yano S, Nishijo H, Kiuchi Y, Teplow DB, Ono K.　FASEB J.　2019/08
• 　Intramolecular interaction suggests an autosuppression mechanism for the innate immune adaptor protein MyD88.　Uno M, Watanabe-Nakayama T, Konno H, Akagi KI, Tsutsumi N, Fukao T, Shirakawa M, Ohnishi H, Tochio H　Chem Commun (Camb)　54　87　12318-12321　2018/10/30
• 　High-Speed Atomic Force Microscopy of Individual Amyloidogenic Protein Assemblies　Watanabe-Nakayama T, Ono K　Methods Mol Biol　1814　201-212　2018
• 　Membrane wound healing at single cellular level　Afrin R, Saito M, Watanabe-Nakayama T, Ikai A.　Nanomedicine　13　7　2351-2357　2017/07/26

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Conference Presentations

• Nano-space video imaging of amyloidogenic protein aggregation(conference：International Symposium on Pathomechanisms of Amyloid Diseases)(2018/12/20)
• Video-imaging of Structural Dynamics of Protein Assemblies(conference：International Symposium on Atomic Force Microscopy at Solid-Liquid Interfaces)(2017/11/09)
• NANOMETER RESOLUTION VIDEO IMAGING REVEALS STRUCTURAL DYNAMICS OF SINGLE AMYLOIDOGENIC PROTEIN ASSEMBLIES(conference：The 5th Asia Pacific Protein Association Conference / The 12th International Symposium of The Protein Society of Thailand)(2017/07/13)
• NANO-SPACE VIDEO IMAGING REVEALS STRUCTURAL DYNAMICS OF FIBROUS PROTEIN ASSEMBLY AND RELEVANT ENZYMES(conference：the 61st annual meeting of Biophysical Society)(2017/02/15)
• High-speed atomic force microscopy directly visualizes amyloidogenic protein structural dynamics(conference：The 39th annual meeting of the Molecular Biology Society of Japan)(2016/11/30)

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Others

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「高速AFMによるアミロイド脱凝集酵素Hsp104の分子動態の解明」(2016-2019)　
○「高速原子間力顕微鏡を用いたコラゲナーゼによるコラーゲン消化メカニズムの解明」(2013-2014)　
○「アクチンストレスファイバーの力学応答に伴う構造変化の高速ＡＦＭ観察」(2012-2013)　

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

○Plant Physiology Lab(2019)
○Research Work in Biology(1)(2019)
○Research Work in Biology(2)(2019)
○Research Seminar in Biology (1)(2019)
○Research Seminar in Biology (2)(2019)
○Guide to Biology and Bioengineering A(2018)
○Plant Physiology Lab(2018)
○Research Work in Biology(1)(2018)
○Research Work in Biology(2)(2018)
○Research Seminar in Biology (1)(2018)
○Research Seminar in Biology (2)(2018)
○Plant Physiology Lab(2017)
○Research Work in Biology(2)(2017)
○Plant Physiology Lab(2017)
○Research Seminar in Biology (1)(2017)
○Presentation and Debate (Freshman Seminar II)(2017)
○Research Work in Biology(1)(2017)
○Research Seminar in Biology (2)(2017)
○Presentation and Debate (Freshman Seminar II)(2017)
○Freshman Seminar I(2017)
○Research Work in Biology(2)(2016)
○Research Seminar in Biology (2)(2016)
○Research Work in Biology(1)(2016)
○Research Seminar in Biology (1)(2016)
○Plant Physiology Lab(2016)

Classes (Graduate Schools)