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last modified：2025/03/29
Associate Professor HAZAWA, Masaharu
Faculty, Affiliation
Institute for Frontier Science Initiative
College and School Educational Field
Division of Natural Sciences, Graduate School of Natural Science and Technology
Laboratory
Academic Background
【Degree】
Ph.D (Health Science)
Career
Institute for Frontier Science Initiative, Innovative Integrated Bio-research core, Cell Bionomics Unit(2016/01/01-)
Cancer Science Institute of Singapore, National University of Singapore(2014/01/01-2015/12/30)
National Institute of Radiological Sciences(2011/04/01-2013/12/31)
Year & Month of Birth
1982/10
Academic Society
The American Society for Cell Biology
Award
Specialities
Genetics/Chromosome dynamics、Tumor biology、Cell biology
Speciality Keywords
Genomic information and Function,Cancer Cell and Molecular Biology,Radiation Biology
Research Themes
Gene expression networks in cell fate determination
Books
Papers
- Super-enhancer trapping by the nuclear pore via intrinsically disordered regions of proteins in squamous cell carcinoma cells Masaharu Hazawa,Dini Kurnia Ikliptikawati,Yuki Iwashima,De-Chen Lin,Yuan Jiang,Yujia Qiu,Kei Makiyama,Koki Matsumoto,Akiko Kobayashi,Goro Nishide,Lim Keesiang,Hironori Yoshino,Toshinari Minamoto,Takeshi Suzuki,Isao Kobayashi,Makiko Meguro-Horike,Yan-Yi Jiang,Takumi Nishiuchi,Hiroki Konno,H. Phillip Koeffler,Kazuyoshi Hosomichi,Atsushi Tajima,Shin-ichi Horike,Richard W. Wong Cell Chemical Biology 2023/11
- Reciprocal inhibition between TP63 and STAT1 regulates anti-tumor immune response through interferon-γ signaling in squamous cancer Yuan Jiang,Yueyuan Zheng,Yuan Wei Zhang,Shuai Kong,Jinxiu Dong,Fei Wang,Benjamin Ziman,Sigal Gery,Jia Jie Hao,Dan Zhou,Jianian Zhou,Allen S. Ho,Uttam K. Sinha,Jian Chen,Shuo Zhang,Chuntong Yin,Dan Dan Wei,Masaharu Hazawa,Huaguang Pan,Zhihao Lu,Wen Qiang Wei,Ming Rong Wang,H. Phillip Koeffler,De Chen Lin,Yan Yi Jiang Nature Communications 15 1 2024/12
- Nuclear transport surveillance of p53 by nuclear pores in glioblastoma Dini Kurnia Ikliptikawati,Nozomi Hirai,Kei Makiyama,Hemragul Sabit,Masashi Kinoshita,Koki Matsumoto,Keesiang Lim,Makiko Meguro-Horike,Shin-ichi Horike,Masaharu Hazawa,Mitsutoshi Nakada,Richard W. Wong Cell Reports 112882 2023/08
- Discovery of a Novel Aminocyclopropenone Compound That Inhibits BRD4-Driven Nucleoporin NUP210 Expression and Attenuates Colorectal Cancer Growth Kondo, H.,Mishiro, K.,Iwashima, Y.,Qiu, Y.,Kobayashi, A.,Lim, K.,Domoto, T.,Minamoto, T.,Ogawa, K.,Kunishima, M.,Hazawa, M.,Wong, R.W. Cells 11 3 317 2022
- NSP9 of SARS-CoV-2 attenuates nuclear transport by hampering nucleoporin 62 dynamics and functions in host cells Kei Makiyama,Masaharu Hazawa,Akiko Kobayashi,Keesiang Lim,Dominic C. Voon,Richard W. Wong Biochemical and Biophysical Research Communications 586 137 2022/01
- A light-switching pyrene probe to detect phase-separated biomolecules. Masaharu Hazawa,Shogo Amemori,Yoshio Nishiyama,Yoshihiro Iga,Yuki Iwashima,Akiko Kobayashi,Hirohisa Nagatani,Motohiro Mizuno,Kenji Takahashi,Richard W Wong iScience 24 8 102865 2021/08/20
- Activation of bivalent factor DLX5 cooperates with master regulator TP63 to promote squamous cell carcinoma. Yongsheng Huang,Qian Yang,Yueyuan Zheng,Lehang Lin,Xin Xu,Xiu-E Xu,Tiago C Silva,Masaharu Hazawa,Li Peng,Haotian Cao,Yanbing Ding,Daning Lu,Benjamin P Berman,Li-Yan Xu,En-Min Li,Dong Yin Nucleic acids research 2021/08/09
- Co-activation of super-enhancer-driven CCAT1 by TP63 and SOX2 promotes squamous cancer progression. Yuan Jiang,Yan-Yi Jiang,Jian-Jun Xie,Anand Mayakonda,Masaharu Hazawa,Li Chen,Jin-Fen Xiao,Chun-Quan Li,Mo-Li Huang,Ling-Wen Ding,Qiao-Yang Sun,Liang Xu,Deepika Kanojia,Maya Jeitany,Jian-Wen Deng,Lian-Di Liao,Harmik J Soukiasian,Benjamin P Berman,Jia-Jie Hao,Li-Yan Xu,En-Min Li,Ming-Rong Wang,Xin-Gang Bi,De-Chen Lin,H Phillip Koeffler Nature communications 9 1 3619 2018/09/06
- Disease-specific alteration of karyopherin-α subtype establishes feed-forward oncogenic signaling in head and neck squamous cell carcinoma. Masaharu Hazawa,Kie Sakai,Akiko Kobayashi,Hironori Yoshino,Yoshihiro Iga,Yuki Iwashima,Kee Sing Lim,Dominic Chih-Cheng Voon,Yan-Yi Jiang,Shin-Ichi Horike,De-Chen Lin,Richard W Wong Oncogene 39 10 2212 2020/03
- TP63, SOX2, and KLF5 Establish a Core Regulatory Circuitry That Controls Epigenetic and Transcription Patterns in Esophageal Squamous Cell Carcinoma Cell Lines. Yan-Yi Jiang,Yuan Jiang,Chun-Quan Li,Ying Zhang,Pushkar Dakle,Harvinder Kaur,Jian-Wen Deng,Ruby Yu-Tong Lin,Lin Han,Jian-Jun Xie,Yiwu Yan,Ngan Doan,Yueyuan Zheng,Anand Mayakonda,Masaharu Hazawa,Liang Xu,YanYu Li,Luay Aswad,Maya Jeitany,Deepika Kanojia,Xin-Yuan Guan,Jonathan W Said,Wei Yang,Melissa J Fullwood,De-Chen Lin,H Phillip Koeffler Gastroenterology 159 4 1311 2020/10
- Interplay and cooperation between SREBF1 and master transcription factors regulate lipid metabolism and tumor-promoting pathways in squamous cancer. Li-Yan Li,Qian Yang,Yan-Yi Jiang,Wei Yang,Yuan Jiang,Xiang Li,Masaharu Hazawa,Bo Zhou,Guo-Wei Huang,Xiu-E Xu,Sigal Gery,Ying Zhang,Ling-Wen Ding,Allen S Ho,Zachary S Zumsteg,Ming-Rong Wang,Melissa J Fullwood,Stephen J Freedland,Stephen J Meltzer,Li-Yan Xu,En-Min Li,H Phillip Koeffler,De-Chen Lin Nature communications 12 1 4362 2021/07/16
- Spatiotemporally tracking of nano-biofilaments inside the nuclear pore complex core. Mahmoud Shaaban Mohamed,Masaharu Hazawa,Akiko Kobayashi,Laurent Guillaud,Takahiro Watanabe-Nakayama,Mizuho Nakayama,Hanbo Wang,Noriyuki Kodera,Masanobu Oshima,Toshio Ando,Richard W Wong Biomaterials 256 120198 2020/10
- Karyopherin-β1 Regulates Radioresistance and Radiation-Increased Programmed Death-Ligand 1 Expression in Human Head and Neck Squamous Cell Carcinoma Cell Lines. Masaharu Hazawa,Hironori Yoshino,Yuta Nakagawa,Reina Shimizume,Keisuke Nitta,Yoshiaki Sato,Mariko Sato,Richard W Wong,Ikuo Kashiwakura Cancers 12 4 908 2020/04/08
- ROCK-dependent phosphorylation of NUP62 regulates p63 nuclear transport and squamous cell carcinoma proliferation. Masaharu Hazawa,De-Chen Lin,Akiko Kobayashi,Yan-Yi Jiang,Liang Xu,Firli Rahmah Primula Dewi,Mahmoud Shaaban Mohamed,Hartono,Mitsutoshi Nakada,Makiko Meguro-Horike,Shin-Ichi Horike,H Phillip Koeffler,Richard W Wong EMBO reports 19 1 73 2018/01
- Targeting super-enhancer-associated oncogenes in oesophageal squamous cell carcinoma. Yan-Yi Jiang,De-Chen Lin,Anand Mayakonda,Masaharu Hazawa,Ling-Wen Ding,Wen-Wen Chien,Liang Xu,Ye Chen,Jin-Fen Xiao,William Senapedis,Erkan Baloglu,Deepika Kanojia,Li Shang,Xin Xu,Henry Yang,Jeffrey W Tyner,Ming-Rong Wang,H Phillip Koeffler Gut 66 8 1358 2017/08
- ZNF750 is a lineage-specific tumour suppressor in squamous cell carcinoma M. Hazawa,D-C Lin,H. Handral,L. Xu,Y. Chen,Y-Y Jiang,A. Mayakonda,L-W Ding,X. Meng,A. Sharma,S. Samuel,M. M. Movahednia,R. W. Wong,H. Yang,C. Tong,H. P. Koeffler ONCOGENE 36 16 2243 2017/04
- Novel function of HATs and HDACs in homologous recombination through acetylation of human RAD52 at double-strand break sites. Takeshi Yasuda,Wataru Kagawa,Tomoo Ogi,Takamitsu A Kato,Takehiro Suzuki,Naoshi Dohmae,Kazuya Takizawa,Yuka Nakazawa,Matthew D Genet,Mika Saotome,Michio Hama,Teruaki Konishi,Nakako Izumi Nakajima,Masaharu Hazawa,Masanori Tomita,Manabu Koike,Katsuko Noshiro,Kenichi Tomiyama,Chizuka Obara,Takaya Gotoh,Ayako Ui,Akira Fujimori,Fumiaki Nakayama,Fumio Hanaoka,Kaoru Sugasawa,Ryuichi Okayasu,Penny A Jeggo,Katsushi Tajima PLoS genetics 14 3 e1007277 2018/03
- The genomic landscape of nasopharyngeal carcinoma. De-Chen Lin,Xuan Meng,Masaharu Hazawa,Yasunobu Nagata,Ana Maria Varela,Liang Xu,Yusuke Sato,Li-Zhen Liu,Ling-Wen Ding,Arjun Sharma,Boon Cher Goh,Soo Chin Lee,Bengt Fredrik Petersson,Feng Gang Yu,Paul Macary,Min Zin Oo,Chan Soh Ha,Henry Yang,Seishi Ogawa,Kwok Seng Loh,H Phillip Koeffler Nature genetics 46 8 866 2014/08
- Vitronectin improves cell survival after radiation injury in human umbilical vein endothelial cells. Masaharu Hazawa,Takeshi Yasuda,Katsuko Noshiro,Ai Saotome-Nakamura,Tomoko Fukuzaki,Yuichi Michikawa,Takaya Gotoh,Katsushi Tajima FEBS open bio 2 334 2012
- Aconitum C₂₀-diterpenoid alkaloid derivatives regulate the growth and differentiation of cord blood derived human hematopoietic stem/progenitor cells. Masaharu Hazawa,Koji Wada,Ikuo Kashiwakura Phytotherapy research : PTR 26 8 1262 2012/08
- Suppressive effects of novel derivatives prepared from Aconitum alkaloids on tumor growth. Masaharu Hazawa,Koji Wada,Kenji Takahashi,Takao Mori,Norio Kawahara,Ikuo Kashiwakura Investigational new drugs 27 2 111 2009/04
Conference Presentations
- Cancer specific alteration and dynamics of nuclear pore proteins establish oncogenic signalling(conference：invited seminar at Deportment of Hematology, West China Hospital, Sichuan University)(2019/02/28)
- Disease-specific alteration of karyopherin-alpha subtypes establishes feedforward oncogenic signaling in squamous cell carcinoma. (conference：The 2018 ASCB | EMBO Meeting)(2018/12/28)
- The Spatiotemporal dynamics of nucleoporin Nup58 during cell division(conference：第41回日本分子生物学会年会)(2018/11/28)
- Nuclear transport system caused by disease-specific Karyopherin alternation(conference：Joint Annual Meeting of 70th JSCB and 51st JSDB)(2018/06/05)
- An oncogenic role of Tpr in Ependymoma(conference：Joint Annual Meeting of 70th JSCB and 51st JSDB)(2018/06/05)
- The role of nucleoporin NUP58 during division(conference：Joint Annual Meeting of 70th JSCB and 51st JSDB)(2018/06/05)
Others
Arts and Fieldwork
Patent
Theme to the desired joint research
Grant-in-Aid for Scientific Research
○「放射線DNA損傷応答における相分離の理解と制御」(2023-2026)
○2022「がん悪性化の根幹であるマスター転写因子の発現誘導メカニズムの解明」(2020-2022)
○「皮膚組織幹細胞特異的エピジェネティクス制御機構を標的とした扁平上皮癌治療戦略」(2017-2019)
○「線溶因子を介したVNプロセッシング制御と細胞死制御機構の解明」(2013-2015)
Competitive research funding,Contribution
Collaborative research,Consignment study
Classes (Bachelors)
○Recombinant Dna Technology Lab(2017)
○Gene･Genome･Neuron･Time･Life(2016)
○Gene･Genome･Neuron･Time･Life(2016)
○Recombinant Dna Technology Lab(2016)
○Recombinant Dna Technology Lab(2016)
Classes (Graduate Schools)
○Integrated Systems Biology A(2017)
○Integrated Systems Biology B(2017)