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Researcher Information

last modified:2017/07/15

Assistant Professor Hiroyasu Kamei

Mail

Faculty, Affiliation

Faculty of Natural System, Institute of Science and Engineering

College and School Educational Field

Division of Natural Sciences, Graduate School of Natural Science and Technology
School of Natural System, College of Science and Engineering

Laboratory

Kamei Lab (Laboratory of Animal Growth and Development) TEL:0768-74-1151 FAX:0768-74-1644

Academic Background

【Academic background(Doctoral/Master's Degree)】
The University of Tokyo Doctor Department of Aquatic Bioscience 200503 Completed
The University of Tokyo Master Department of Aquatic Bioscience 200203 Completed
【Academic background(Bachelor's Degree)】
Utsunomiya University 200003
【Degree】
Doctor of Philosophy

Career

Kanazawa University Faculty of Natural System, Institute of Science and Engineering Assistant Professor (Specialized in Research)(2016/02-)
The University of Tokyo Graduate School of Agriculture and Life Sciences Postdoctoral research fellow/Assistant professor(2011/01-2016/01)
University of Michigan Department of Molecular, Cellular, and Developmental Biology (MCDB) JSPS Postdoctoral Fellowship for Research Abroad (2008/04-2010/03)
University of Michigan Department of Molecular, Cellular, and Developmental Biology (MCDB) Postdoctoral Fellow (2005/08-2010/12)
The University of Tokyo Graduate School of Agriculture and Life Sciences Research fellow(2005/04-2005/07)
The University of Tokyo Graduate School of Agriculture and Life Sciences JSPS Research Fellowship for Young Scientist (DC1)(2002/04-2005/03)

Year & Month of Birth

1977/09

Academic Society

The Japan Endocrine Society
The Japan Society for Comparative Endocrinology
The North American Society for Comparative Endocrinology

Award

○Gordon Research Conference, Travel Award (2015/03)
○7th International Congress of the GRS-IGF Society, Travel Award (2014/10)
○NIG Collaborative Research Program (2012/04)
○1st NASCE, Endocrine Society Travel Award (2011/07)
○Best poster prize in International Symposium of “Advances in Eel Biology”(2001/09)

Specialities

Integrative animal science、Applied molecular and cellular biology、Developmental biology、Endocrinology、Aquatic life science

Speciality Keywords

Embryonic growth, Hypoxia, Growth retardation, Catch-up growth, Zebrafish, Insulin/IGF-signalling, Neural crest cells

Research Themes

Molecular mechanisms regulating catch-up growth

Most animals retard growth in response to adverse conditions; however, upon the removal of unfavorable factors, they often show quick growth restoration, which is known as “catch-up” growth. Albeit the catch-up growth is important for the accidentally stunted wild animal to regain its size and renew competition with non-stunted one, the molecular mechanism of such unique growth spurt remains largely unknown. In this project, by using zebrafish model of hypoxia-reoxygenation induced catch-up growth, we want to know when, where, and how the embryonic growth signal changes to facilitate the catch-up growth.

Effects of anomalistic growth pattern on neural crest cell development

It has been known that severe embryonic growth retardation and subsequent catch-up growth often associate with adult-onset disorders such as hypertension and diabetes. Though the changes during such an anomalistic growth pattern seem to be a key for deciphering the cause of future pathogenesis of stunted animals, the cellular basis of the phenomenon remains to be elucidated. We tackle this issue by exploring the effect of the embryonic growth retardation and the catch-up growth on the development of neural crest cells, multi-potent embryonic stem cells, in zebrafish embryos.

Books

Papers

  •  Role of IGF signaling in catch-up growth and accelerated temporal development in zebrafish embryos in response to oxygen availability. Kamei H., Ding Y., Kajimura S., Wells M., Chiang P., Duan C. Development 138 pp. 777-786 2011/02
  •  In vivo loss of function study reveals the short stature homeobox-containing gene plays indispensable roles in early embryonic growth and bone formation in zebrafish. Sawada R., Kamei H.(Co-first & Co-corresponding authorships), Hakuno F., Takahashi S., Shimizu T. Developmental Dynamics 244 pp. 146-156 2015/02
  •  Nedd4-induced monoubiquitination of IRS-2 enhances IGF signalling and mitogenic activity. Fukushima T., Yoshihara H., Furuta H., Kamei H., Hakuno F., Luan J., Duan C., Saeki Y., Tanaka K., Iemura S., Natsume T., Chida K., Nakatsu Y., Kamata H., Asano T., Takahashi S. Nature Communications 6 6780(article number) pp.1-14 2015/04
  •  Duplication and diversification of the hypoxia-inducible IGFBP-1 gene in zebrafish. Kamei H., Lu L., Jiao S., Li Y., Gyrup C., Laursen L.S., Oxvig C., Zhou J., Duan C. PLoS ONE 3 e3091 2008/08
  •  Oxygen regulates Insulin-like growth factor signalling: mechanisms of altered embryonic growth via changing environmental oxygen level.  Kamei H., Kajimura S., Duan C., Takahashi S. Kagaku to Seibutu 50 pp. 11-13 2012/01

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  •  The Short-Stature Homeobox-Containing Gene (shox/SHOX) Is Required for the Regulation of Cell Proliferation and Bone Differentiation in Zebrafish Embryo and Human Mesenchymal Stem Cells.  Yokokura T., Kamei H.(co-first authorship & co-corresponding authorship), Shibano T., Yamanaka D., Sawada-Yamaguchi R., Hakuno F., Takahashi S., Shimizu T. Front. Endocrinol. https://doi.org/10.3389/fendo. 2017/06/08
  •  USP40 gene knockdown disrupts glomerular permeability in zebrafish. Takagi H., Nishibori Y., Katayama K., Katada T., Takahashi S., Kiuchi Z., Takahashi S.I., Kamei H., Kawakami H., Akimoto Y., Kudo A., Asanuma K., Takematsu H., Yan K. Am. J. Physiol. Renal Physiol. 2017/02/01
  •  Zebrafish IGF genes: gene duplication, conservation and divergence, and novel roles in midline and notochord development. Zou S., Kamei H., Modi Z., Duan C. PLoS ONE 4 e7026 2009/09
  •  Role of IGF signaling in catch-up growth in zebrafish embryos in response to oxygen availability. Hiroyasu Kamei Comparative Endocrinology 37 pp. 170-173 2011/09
  •  The novel functions of high-molecular-mass complexes containing insulin receptor substrates in mediation and modulation of insulin-like activities: Emerging concept of diverse function by IRS-associated proteins. Hakuno F., Fukushima T., Yoneyama Y., Kamei H., Ozoe A., Yoshihara H., Yamanaka D., Shibano T., Sone-Yonezawa M., Yu B.C., Chida K., Takahashi S. Front. Endocrinol. 6 73(article number) pp. 1-18 2015/05
  •   Diseases in the Aging Society Caused by Modulation of Insulin-Like Activities. Takahashi S., Hakuno F., Kamei H., Girnita L., Torres-Aleman I., Higashi Y., Fukushima T., Shibano T., Ozoe A. Kagaku to Seibutsu 51 pp. 389-399 2013/06
  •  Hypoxia and leucine deprivation induce human IGFBP-1 hyper-phosphorylation and increase its biological activity. Seferovic M.D., Ali R., Kamei H., Liu S., Khosravi J.M., Nazarian S., Han V.K., Duan C., Gupta MB. Endocrinology 150 pp. 220-231 2009/01
  •  Inducible transgenesis in the short-lived fish Nothobranchius furzeri. Allard J.B., Kamei H., Duan C. J. Fish Biol. 82 pp. 1733-1738 2013/05
  •  Acetylcholinesterase (AChE) inhibition aggravates fasting-induced triglyceride (TG) accumulation in the mouse liver. Yokota S., Nakamura K., Ando M., Kamei H., Hakuno F., Takahashi S., Shibata S. FEBS Open Bio 22 pp. 905-914 2014/10
  •  Insulin receptor substrate-1 promotes embryonic growth through IGF-IR signal-dependent and -independent mechanisms in response to developmental stages and environmental oxygen availability. Kamei H., Sawada R., Yoneyama Y., Hakuno F., Shimizu T., Takahashi S. Growth hormone & IGF research 24 pp.S16 2014/10
  •  Pregnancy-associated plasma protein-A (PAPP-A) modulates early developmental rate in zebrafish independent of its proteolytic activity. Kjaer-Sorensen K., Engholm D.H., Kamei H., Morch M.G., Kristensen A.O., Zhou J., Conover C.A., Duan C., Oxvig C. J. Biol. Chem. 288 pp.9982-9992 2013/04
  •  Steroid hormones are novel nucleoside transport inhibitors by competition with nucleosides for their transporters. Kaneko M., Hakuno F., Kamei H., Yamanaka D., Chida K., Minami S., Coe I.R., Takahashi S. Biochem. Biophys. Res. Commun. 443 pp. 505-510 2014/01
  •  Subfunctionalization of cyprinid hypoxia-inducible factors for roles in development and oxygen-sensing. Rytkönen K.T., Akbarzadeh A., Miandare H.K., Kamei H., Duan C., Leder E.H., Williams T.A., Nikinmaa M. Evolution 67 pp. 873-882 2013/03
  •  IGF signaling regulates catch-up growth and accelerated developmental timing in zebrafish embryos in response to oxygen availability. Kamei H., Ding Y., Kajimura S., Wells M., Chiang P., Duan C. Growth hormone & IGF research 20 pp. S81 2010/09
  •  Duplicated zebrafish insulin-like growth factor binding protein-5 genes with split functional domains: evidence for evolutionarily conserved IGF binding, nuclear localization, and transactivation activity. Dai W., Kamei H., Zhao Y., Ding J., Du Z., Duan C. FASEB J. 24 pp. 2020-2029 2010/06
  •  Duplication of the IGFBP-2 gene in teleost fish: Protein structure and functionality conservation and gene expression divergence. Zhou J., Li W., Kamei H., Duan C. PLoS ONE 3 e3926 2008/12
  •  Follicle-stimulating hormone induces spermatogenesis mediated by androgen production in Japanese eel, Anguilla japonica. Ohta T., Miyake H., Miura C., Kamei H., Aida K., Miura T. Biol. Reprod. 77 pp. 970-977 2007/12
  •  In vivo gonadotropic effects of recombinant Japanese eel follicle-stimulating hormone. Kamei H., Kaneko T., Aida K. Aquaculture 261 pp. 771-775 2006/11
  •  Steroidogenic activities of follicle-stimulating hormone in the ovaries of Japanese eel, Anguilla japonica. Kamei H., Kaneko T., Aida K. Gen. Comp. Endocrinol. 146 pp. 83-90 2006/04
  •  Purification of follicle-stimulating hormone from immature Japanese eel, Anguilla japonica, and its biochemical properties and steroidogenic activities. Kamei H., Kawazoe I., Kaneko T., Aida K. Gen. Comp. Endocrinol. 143 pp. 257-266 2005/09
  •  Structural characterization of gonadotropin β subunit genes in a teleost, the medaka Oryzias latipes. (5th AOSCE, Nara, Japan)  Kamei H., Okubo K., Yoshiura Y., Kajimura S., Kawaguchi N., Aida K. Proceedings of 5th Congress of the Asia and Oceania Society for Comparative Endocrinology, “Trends in Comparative Endocrinology” pp. 276-278 2004/03
  •  Expression of a biologically active recombinant follicle-stimulating hormone of Japanese eel Anguilla japonica using methylotropic yeast, Pichia pastoris. Kamei H., Ohira T., Yoshiura Y., Uchida N., Nagasawa H., Aida K. Gen. Comp. Endocrinol. 134 pp. 244-254 2003/12
  •  Biological activity of recombinant gonadotropin-I of the Japanese eel, Anguilla japonica, in methylotrophic yeast, Pichia pastoris. (International symposium of Eel Biology, Tokyo, Japan)  Kamei H., Ohira T., Yoshiura Y., Uchida N., Aida K. Proceeding of the International Symposium “Advances in Eel Biology” pp. 195-197 2001/09
  •  Androgen secretion activity of recombinant follicle-stimulating hormone of Japanese eel, Anguilla japonica in immature and maturing eel testes. Kamei H., Ohira T., Yoshiura Y., Uchida N., Aida K. Fish Physiol. Biochem. 28 pp. 97-98 2003/03
  •  Expression of recombinant gonadotropin-I of the Japanese eel, Anguilla japonica, in methylotrophic yeast, Pichia pastoris. (14th ICCE, Sorrento, Italy)  Kamei H., Ohira T., Yoshiura Y., Uchida N., Aida K. Proceeding of the International Congress of Comparative Endocrinology “Perspective in Comparative Endocrinology: Unity and Diversity” pp. 127-132 2001/05

Conference Presentations

  • Roles of insulin receptor substrates in controlling embryonic growth in response to changing environmental oxygen tension.(conference:18th International Congress of Comparative Endocrinology)(2017/06/04)
  • Roles of Insulin/Insulin-like growth factor signaling in hypoxia/reoxygenation induced catch-up growth in zebrafish embryo.(conference:INTERNATIONAL SEMINAR “Insulin-like Signaling and Nutrient Signaling: universal signaling for extension of healthy lifespan and improvement of quality for humans and animals”)(2017/01/24)
  • Catch-up growth in tiny fish embryos: Roles of IIS in accelerated growth induced by changing environmental oxygen availability. (conference:“The Model Organism Conference at Kanazawa”)(2016/10/07)
  • Insulin receptor substrate-1 promotes embryonic growth through IGF-IR signal-dependent and -independent mechanisms in response to developmental stages and environmental oxygen availability.(conference:The 7th International Congress of GRS and IGF Society)(2014/10)
  • Roles of insulin receptor substrate-1 in catch-up growth: A lesson from tiny fish embryo.(conference:INTERNATIONAL SEMINAR “Evolution of Insulin-like Peptides and Their Function:Development, Growth, Metabolism and Ageing”)(2014/10)

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  • Early embryonic regulation of PI3K signaling:Identification and characterization of non-canonical PI3K interacting molecules, and their roles in embryogenesis.(conference:INTERNATIONAL OPEN WORKSHOP “Emerging Paradigms of Insulin-Like Activities in Physiology & Disease: From Pathophysiology to Targeted Therapy”)(2013/08)
  • Regulation of allometry by modulating local IGF actions: role of IGF binding proteins.(conference:The inaugural meeting of the North American Society for Comparative Endocrinology (NASCE 2011))(2011/07)

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「追いつき成長における神経堤細胞のインスリン様活性の生理的意義の解明」(2015-2016) 
○「初期胚に見出されたホスファチジルイノシトール3キナーゼ結合分子の機能解析」(2013-2014) 
○「初期胚発生特異的ホスファチジルイノシトール3キナーゼ活性制御タンパク質の探索」(2011-2012) 
○「魚類の加齢が再生産能に及ぼす影響の解析:老化抑制遺伝子を用いた解析の試み」(2008-2009) 
○「組換え体ウナギ生殖腺刺激ホルモンの生理作用の解明と人為催熟への応用」(2002-2004) 

Classes (Bachelors)

○Marine Biochemistry(2017)
○Marine Biochemistry(2017)
○Basic Biology Lab(2016)
○Marine Biochemistry(2016)
○Gene・Genome・Neuron・Time・Life(2016)
○Gene・Genome・Neuron・Time・Life(2016)

Classes (Graduate Schools)

○Integrated Systems Biology B(2017)
○Integrated Systems Biology A(2017)

International Project

International Students

Lecture themes

Others (Social Activities)

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