Assistant Professor MURAI, Kazuhisa
Faculty, Affiliation
Faculty of Health Sciences, Institute of Medical, Pharmaceutical and Health Sciences
College and School Educational Field
Division of Health Sciences, Graduate School of Medical Science
Department of Laboratory Sciences，School of Health Sciences, College of Medical, Pharmaceutical and Health Sciences
Laboratory
Academic Background
Career
Kanazawa University
Kanazawa University
Kanazawa University(2019/09/01-)
Year & Month of Birth
Academic Society
Award
Specialities
、、、Gastroenterology
Speciality Keywords
Research Themes
・ Elucidation of the underlying mechanism of liver cancer immunosuppression based on the understanding of cancer cell metabolism
・ Development of anti-HBV drugs targeting host factors for cccDNA eradication
・ Elucidation of infection immune control mechanism by lipase
Books
Papers
- A single hepatitis B virus genome with a reporter allows the entire viral life cycle to be monitored in primary human hepatocytes. Ariunaa Sumiyadorj,Kazuhisa Murai,Tetsuro Shimakami,Kazuyuki Kuroki,Tomoki Nishikawa,Masaki Kakuya,Atsumu Yamada,Ying Wang,Atsuya Ishida,Takayoshi Shirasaki,Shotaro Kawase,Ying-Yi Li,Hikari Okada,Kouki Nio,Kazunori Kawaguchi,Taro Yamashita,Yoshio Sakai,Davaadorj Duger,Eishiro Mizukoshi,Masao Honda,Shuichi Kaneko Hepatology communications 2022/06/12
- Leukocyte cell-derived chemotaxin 2 is an antiviral regulator acting through the proto-oncogene MET. Takayoshi Shirasaki,Satoshi Yamagoe,Tetsuro Shimakami,Kazuhisa Murai,Ryu Imamura,Kiyo-Aki Ishii,Hiroaki Takayama,Yukako Matsumoto,Natsumi Tajima-Shirasaki,Naoto Nagata,Ryogo Shimizu,Souma Yamanaka,Atsushi Abe,Hitoshi Omura,Kazunori Kawaguchi,Hikari Okada,Taro Yamashita,Tomoki Yoshikawa,Kazuhiro Takimoto,Motoko Taharaguchi,Shogo Takatsuka,Yoshitsugu Miyazaki,Toshikatsu Tamai,Yamato Tanabe,Makoto Kurachi,Yasuhiko Yamamoto,Shuichi Kaneko,Kunio Matsumoto,Toshinari Takamura,Masao Honda Nature communications 13 1 3176 2022/06/08
- Establishment of liver tumor cell lines from atherogenic and high fat diet fed hepatitis C virus transgenic mice. Takayoshi Shirasaki,Kazuhisa Murai,Masao Honda,Hikari Okada,Yuika Innami,Atsumu Yamada,Tetsuro Shimakami,Kazunori Kawaguchi,Taro Yamashita,Yoshio Sakai,Shuichi Kaneko Scientific reports 11 1 13021 2021/06/22
- Induction of Selenoprotein P mRNA during Hepatitis C Virus Infection Inhibits RIG-I-Mediated Antiviral Immunity. Kazuhisa Murai,Masao Honda,Takayoshi Shirasaki,Tetsuro Shimakami,Hitoshi Omura,Hirofumi Misu,Yuki Kita,Yumie Takeshita,Kiyo-Aki Ishii,Toshinari Takamura,Takeshi Urabe,Ryogo Shimizu,Hikari Okada,Taro Yamashita,Yoshio Sakai,Shuichi Kaneko Cell host & microbe 25 4 588 2019/04/10
- Peretinoin, an Acyclic Retinoid, Inhibits Hepatitis B Virus Replication by Suppressing Sphingosine Metabolic Pathway In Vitro. Kazuhisa Murai,Takayoshi Shirasaki,Masao Honda,Ryogo Shimizu,Tetsuro Shimakami,Saki Nakasho,Natsumi Shirasaki,Hikari Okada,Yoshio Sakai,Taro Yamashita,Shuichi Kaneko International journal of molecular sciences 19 2 2018/01/23
- Hepatitis B Virus Utilizes a Retrograde Trafficking Route via the Trans-Golgi Network to Avoid Lysosomal Degradation. Ying-Yi Li,Kazuyuki Kuroki,Tetsuro Shimakami,Kazuhisa Murai,Kazunori Kawaguchi,Takayoshi Shirasaki,Kouki Nio,Saiho Sugimoto,Tomoki Nishikawa,Hikari Okada,Noriaki Orita,Hideo Takayama,Ying Wang,Phuong Doan Thi Bich,Astuya Ishida,Sadahiro Iwabuchi,Shinichi Hashimoto,Takeshi Shimaoka,Noriko Tabata,Miho Watanabe-Takahashi,Kiyotaka Nishikawa,Hiroshi Yanagawa,Motoharu Seiki,Kouji Matsushima,Taro Yamashita,Shuichi Kaneko,Masao Honda Cellular and molecular gastroenterology and hepatology 15 3 533 2023
Conference Presentations
- Induction of Selenoprotein P mRNA During Hepatitis C Virus Infection Inhibits RIG-I-Mediated Antiviral Immunity (conference：AASLD)(2019/11/10)
Others
Arts and Fieldwork
Patent
Theme to the desired joint research
Grant-in-Aid for Scientific Research
○「B型肝炎ウイルスRNAを制御する宿主因子の機能解析」(2024-2026)
○「シングルセルマルチオミックス解析による肝がん微小環境の解明」(2022-2023)
○「新規モニタリング法の確立によるB型肝炎ウイルスを完全駆除する薬物の探索と同定」(2023-2025)
○「B型・D型肝炎ウイルス共感染が引き起こす肝疾患の分子生物学的機序の解明」(2020-2023)
○「RIP-Seq法を用いたRIG-IのRNA decoy探索と核酸医薬への応用」(2019-2021)
Competitive research funding,Contribution
Collaborative research,Consignment study
Classes (Bachelors)
○Lecture and Practice of Virology(2023)
○Molecular Biology(2023)
○Gene Diagnostics(2023)
○Clinial Practice of Pathologic Microbiology(2023)
○Presentation and Debate(2023)
○Parasitology(2023)
○Laboratory of Serology and Immunology(2023)
○Pathogenic Microbiology 2(2023)
○Academic Skill(2023)
○Clinial Practice of Pathologic Microbiology(2022)
○Exercise on Recombinant DNA Technology(2022)
○Lecture and Practice of Virology(2022)
○Pathogenic Microbiology 2(2022)
○Laboratory of Serology and Immunology(2022)
○Parasitology(2022)
○Presentation and Debate (Freshman Seminar II)(2021)
○Introduction to Region-studies(2021)
○Freshman Seminar I(2021)
○Parasitology(2021)
○Clinial Practice of Pathologic Microbiology(2021)
○Exercise on Recombinant DNA Technology(2021)
○Lecture and Practice of Virology(2021)
○Pathogenic Microbiology 2(2021)
○Laboratory of Serology and Immunology(2021)
○Lecture and Practice of Virology(2020)
○Exercise on Recombinant DNA Technology(2020)
○Clinial Practice of Pathologic Microbiology(2020)
○Lecture and Practice of Virology(2019)
○Exercise on Recombinant DNA Technology(2019)
○Clinial Practice of Pathologic Microbiology(2019)
Classes (Graduate Schools)
○Molecular Biology of Tumor: Lecture(2023)
○Laboratory Rotation Ｉ(2023)
○Laboratory Rotation Ⅱ(2023)
○An Introduction to Medical Laboratory Sciences:Lec(2022)
○Molecular Biology of Tumor: Lecture(2022)