Specialities

、、、Gastroenterology

Speciality Keywords

Research Themes

Books

Papers

• 　A single hepatitis B virus genome with a reporter allows the entire viral life cycle to be monitored in primary human hepatocytes.　Ariunaa Sumiyadorj,Kazuhisa Murai,Tetsuro Shimakami,Kazuyuki Kuroki,Tomoki Nishikawa,Masaki Kakuya,Atsumu Yamada,Ying Wang,Atsuya Ishida,Takayoshi Shirasaki,Shotaro Kawase,Ying-Yi Li,Hikari Okada,Kouki Nio,Kazunori Kawaguchi,Taro Yamashita,Yoshio Sakai,Davaadorj Duger,Eishiro Mizukoshi,Masao Honda,Shuichi Kaneko　Hepatology communications　2022/06/12
• 　Leukocyte cell-derived chemotaxin 2 is an antiviral regulator acting through the proto-oncogene MET.　Takayoshi Shirasaki,Satoshi Yamagoe,Tetsuro Shimakami,Kazuhisa Murai,Ryu Imamura,Kiyo-Aki Ishii,Hiroaki Takayama,Yukako Matsumoto,Natsumi Tajima-Shirasaki,Naoto Nagata,Ryogo Shimizu,Souma Yamanaka,Atsushi Abe,Hitoshi Omura,Kazunori Kawaguchi,Hikari Okada,Taro Yamashita,Tomoki Yoshikawa,Kazuhiro Takimoto,Motoko Taharaguchi,Shogo Takatsuka,Yoshitsugu Miyazaki,Toshikatsu Tamai,Yamato Tanabe,Makoto Kurachi,Yasuhiko Yamamoto,Shuichi Kaneko,Kunio Matsumoto,Toshinari Takamura,Masao Honda　Nature communications　13　1　3176　2022/06/08
• 　Establishment of liver tumor cell lines from atherogenic and high fat diet fed hepatitis C virus transgenic mice.　Takayoshi Shirasaki,Kazuhisa Murai,Masao Honda,Hikari Okada,Yuika Innami,Atsumu Yamada,Tetsuro Shimakami,Kazunori Kawaguchi,Taro Yamashita,Yoshio Sakai,Shuichi Kaneko　Scientific reports　11　1　13021　2021/06/22
• 　Induction of Selenoprotein P mRNA during Hepatitis C Virus Infection Inhibits RIG-I-Mediated Antiviral Immunity.　Kazuhisa Murai,Masao Honda,Takayoshi Shirasaki,Tetsuro Shimakami,Hitoshi Omura,Hirofumi Misu,Yuki Kita,Yumie Takeshita,Kiyo-Aki Ishii,Toshinari Takamura,Takeshi Urabe,Ryogo Shimizu,Hikari Okada,Taro Yamashita,Yoshio Sakai,Shuichi Kaneko　Cell host & microbe　25　4　588　2019/04/10
• 　Peretinoin, an Acyclic Retinoid, Inhibits Hepatitis B Virus Replication by Suppressing Sphingosine Metabolic Pathway In Vitro.　Kazuhisa Murai,Takayoshi Shirasaki,Masao Honda,Ryogo Shimizu,Tetsuro Shimakami,Saki Nakasho,Natsumi Shirasaki,Hikari Okada,Yoshio Sakai,Taro Yamashita,Shuichi Kaneko　International journal of molecular sciences　19　2　2018/01/23

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Conference Presentations

• Induction of Selenoprotein P mRNA During Hepatitis C Virus Infection Inhibits RIG-I-Mediated Antiviral Immunity (conference：AASLD)(2019/11/10)

Others

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「B型肝炎ウイルスRNAを制御する宿主因子の機能解析」(2024-2026)　
○「シングルセルマルチオミックス解析による肝がん微小環境の解明」(2022-2023)　
○「新規モニタリング法の確立によるB型肝炎ウイルスを完全駆除する薬物の探索と同定」(2023-2025)　
○「B型・D型肝炎ウイルス共感染が引き起こす肝疾患の分子生物学的機序の解明」(2020-2023)　
○「RIP-Seq法を用いたRIG-IのRNA decoy探索と核酸医薬への応用」(2019-2021)　

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

○Clinial Practice of Pathologic Microbiology(2024)
○Molecular Biology Practice(2024)
○Molecular Biology(2024)
○Parasitology(2024)
○Clinical Microbiology 2(2024)
○Molecular Biology(2023)
○Gene Diagnostics(2023)
○Clinial Practice of Pathologic Microbiology(2023)
○Lecture and Practice of Virology(2023)
○Presentation and Debate(2023)
○Parasitology(2023)
○Pathogenic Microbiology 2(2023)
○Laboratory of Serology and Immunology(2023)
○Academic Skill(2023)
○Clinial Practice of Pathologic Microbiology(2022)
○Exercise on Recombinant DNA Technology(2022)
○Lecture and Practice of Virology(2022)
○Laboratory of Serology and Immunology(2022)
○Pathogenic Microbiology 2(2022)
○Parasitology(2022)
○Presentation and Debate (Freshman Seminar II)(2021)
○Introduction to Region-studies(2021)
○Freshman Seminar I(2021)
○Lecture and Practice of Virology(2021)
○Pathogenic Microbiology 2(2021)
○Parasitology(2021)
○Exercise on Recombinant DNA Technology(2021)
○Clinial Practice of Pathologic Microbiology(2021)
○Laboratory of Serology and Immunology(2021)
○Lecture and Practice of Virology(2020)
○Exercise on Recombinant DNA Technology(2020)
○Clinial Practice of Pathologic Microbiology(2020)
○Lecture and Practice of Virology(2019)
○Exercise on Recombinant DNA Technology(2019)
○Clinial Practice of Pathologic Microbiology(2019)

Classes (Graduate Schools)

○An Introduction to Medical Laboratory Sciences:Lec(2024)
○Laboratory Rotation Ⅱ(2024)
○Molecular Biology of Tumor: Lecture(2024)
○Laboratory Rotation I(2024)
○Molecular Biology of Tumor: Lecture(2023)
○Laboratory Rotation Ｉ(2023)
○Laboratory Rotation Ⅱ(2023)
○An Introduction to Medical Laboratory Sciences:Lec(2022)
○Molecular Biology of Tumor: Lecture(2022)