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last modified：2025/04/09
Assistant Professor GOTO, Hisanori
Faculty, Affiliation
University Hospital
Assistant Professor
College and School Educational Field
Laboratory
Academic Background
【Degree】
Doctor of Philosophy in Medical Sciences
Career
Year & Month of Birth
1989/08
Academic Society
Award
Specialities
Metabolomics
Speciality Keywords
Metabolic Dysfunction Associated Steatohepatitis（MASH）, pregestational diabetes mellitus, Oxytocin, obstructive sleep apnea
Research Themes
Books
Papers
- Cysteine redoxome landscape in mouse brown adipose tissue under acute cold exposure Hein Ko Oo, Cynthia M Galicia-Medina, Takumi Nishiuchi, Ryota Tanida, Hisanori Goto, Yujiro Nakano, Yumie Takeshita, Yoshiro Saito, Hiroaki Takayama, Toshinari Takamura iScience. 28 3 112051 2025/02/17
- Oxytocin Receptor Polymorphism Is Associated With Sleep Apnea Symptoms Hisanori Goto, Yasuhiko Yamamoto, Hiromasa Tsujiguchi, Takehiro Sato, Reina Yamamoto, Yumie Takeshita, Yujiro Nakano, Takayuki Kannon, Kazuyoshi Hosomichi, Keita Suzuki, Masaharu Nakamura, Yasuhiro Kambayashi, Jiaye Zhao, Atsushi Asai, Koji Katano, Aya Ogawa, Shinobu Fukushima, Aki Shibata, Fumihiko Suzuki, Hirohito Tsuboi, Akinori Hara, Mitsuhiro Kometani, Shigehiro Karashima, Takashi Yoneda, Atsushi Tajima, Hiroyuki Nakamura, Toshinari Takamura J Endocr Soc. 9 1 bvae198 2024/11/26
- NAFLD/NASH 基礎研究の最前線―病態から治療まで― 後藤 久典, 篁 俊成 肥満研究 30 1 32 2024
- Comparison of Tofogliflozin and Glimepiride Effects on Nonalcoholic Fatty Liver Disease in Participants With Type 2 Diabetes: A Randomized, 48-Week, Open-Label, Active-Controlled Trial Yumie Takeshita 1, Masao Honda 2, Kenichi Harada 3, Yuki Kita 1, Noboru Takata 2, Hiromasa Tsujiguchi 4, Takeo Tanaka 1, Hisanori Goto 1, Yujiro Nakano 1, Noriho Iida 2, Kuniaki Arai 2, Tatsuya Yamashita 2, Eishiro Mizukoshi 2, Hiroyuki Nakamura 4, Shuichi Kaneko 2, Toshinari Takamura 1 Diabetes Care. 45 9 2064–2075 2022/09/01
- Selenoprotein P-mediated reductive stress impairs cold-induced thermogenesis in brown fat Swe Mar Oo 1, Hein Ko Oo 1, Hiroaki Takayama 2, Kiyo-Aki Ishii 3, Yumie Takeshita 1, Hisanori Goto 1, Yujiro Nakano 1, Susumu Kohno 4, Chiaki Takahashi 4, Hiroyuki Nakamura 5, Yoshiro Saito 6, Mami Matsushita 7, Yuko Okamatsu-Ogura 8, Masayuki Saito 8, Toshinari Takamura 9 Cell Reports 38 13 110566 2022/03/29
- Vascular RAGE transports oxytocin into the brain to elicit its maternal bonding behaviour in mice Yasuhiko Yamamoto 1, Mingkun Liang 2, Seiichi Munesue 3, Kisaburo Deguchi 4, Ai Harashima 3, Kazumi Furuhara 2, Teruko Yuhi 2, Jing Zhong 2, Shirin Akther 2, Hisanori Goto 3, Yuya Eguchi 3, Yasuko Kitao 5, Osamu Hori 5, Yoshitake Shiraishi 6, Noriyuki Ozaki 6, Yu Shimizu 3 7, Tomoya Kamide 5 7, Akifumi Yoshikawa 5 7, Yasuhiko Hayashi 7, Mitsutoshi Nakada 7, Olga Lopatina 2 8, Maria Gerasimenko 2, Yulia Komleva 8, Natalia Malinovskaya 8, Alla B Salmina 2 8, Masahide Asano 9, Katsuhiko Nishimori 10, Steven E Shoelson 11, Hiroshi Yamamoto 3 12, Haruhiro Higashida 13 14 Communications Biology 2 76 2019/02/25
- Thyroid Arteriovenous Malformation in Hereditary Hemorrhagic Telangiectasia: Insights on Successful Noninvasive Imaging Hisanori Goto 1, Iyo Tanimura 2, Yujiro Nakano 1, Yumie Takeshita 1, Toshinari Takamura 1 JCEM Case Rep . 2 8 luae138 2024/08/12
- LECT2 Deletion Exacerbates Liver Steatosis and Macrophage Infiltration in a Male Mouse Model of LPS-mediated NASH Ryota Tanida 1 2 3, Hisanori Goto 1, Hiroaki Takayama 4, Yujiro Nakano 1, Hein Ko Oo 1, Cynthia Monserrat Galicia-Medina 1, Kenta Takahashi 5, Kiyo-Aki Ishii 6, Arman Syah Goli 7, Takashi Matsuzaka 7 8, Kenichi Harada 5, Toshinari Takamura 1 Endocrinology . 165 7 bqae059 2024/05/27
- PAC1 Deficiency Protects Obese Male Mice From Immobilization-Induced Muscle Atrophy by Suppressing FoxO-Atrogene Axis Qifang Li 1, Kiyo-Aki Ishii 1 2, Kyoko Kamoshita 1, Kenta Takahashi 3, Halimulati Abuduwaili 1, Hiroaki Takayama 1 4, Cynthia M Galicia-Medina 1, Ryota Tanida 1, Hein Ko Oo 1, Guzel Gafiyatullina 1, Xingyu Yao 1, Tuerdiguli Abuduyimiti 1, Jun Hamazaki 5, Hisanori Goto 1, Yujiro Nakano 1, Yumie Takeshita 1, Kenichi Harada 3, Shigeo Murata 5, Toshinari Takamura 1 Endocrinology. 164 6 bqad065. 2024/04/17
- Selenoprotein P deficiency protects against immobilization-induced muscle atrophy by suppressing atrophy-related E3 ubiquitin ligases Halimulati Abuduwaili 1, Kyoko Kamoshita 1, Kiyo-Aki Ishii 1 2 3, Kenta Takahashi 4, Tuerdiguli Abuduyimiti 1, Li Qifang 1, Yuki Isobe 1, Hisanori Goto 1, Yujiro Nakano 1, Yumie Takeshita 1, Hiroaki Takayama 1 5, Kenichi Harada 4, Toshinari Takamura 1 Am J Physiol Endocrinol Metab. 324 6 E542-E552. 2023/01/01
- Nutrigenetic Interaction Between Apolipoprotein C3 Polymorphism and Fat Intake in People with Nonalcoholic Fatty Liver Disease Reina Yamamoto 1, Yumie Takeshita 1, Hiromasa Tsujiguchi 2, Takayuki Kannon 3, Takehiro Sato 3, Kazuyoshi Hosomichi 3, Keita Suzuki 2, Yuki Kita 1, Takeo Tanaka 1, Hisanori Goto 1, Yujiro Nakano 1, Tatsuya Yamashita 4, Shuichi Kaneko 4, Atsushi Tajima 3, Hiroyuki Nakamura 2, Toshinari Takamura 1 Curr Dev Nutr. 7 4 100051 2023/03/02
- Trajectories of Liver Fibrosis and Gene Expression Profiles in Nonalcoholic Fatty Liver Disease Associated With Diabetes Saori Sako 1, Yumie Takeshita 1, Hiroaki Takayama 1, Hisanori Goto 1, Yujiro Nakano 1, Hitoshi Ando 2, Hiromasa Tsujiguchi 3, Tatsuya Yamashita 4, Kuniaki Arai 4, Shuichi Kaneko 4, Hiroyuki Nakamura 3, Kenichi Harada 5, Masao Honda 4, Toshinari Takamura 1 Diabetes. 72 9 1297-1306 2023/09/01
- Diabetes Accelerates Steatohepatitis in Mice: Liver Pathology and Single-Cell Gene Expression Signatures Tuerdiguli Abuduyimiti 1, Hisanori Goto 1, Kumi Kimura 2, Yu Oshima 2, Ryota Tanida 3, Kyoko Kamoshita 3, Nontaphat Leerach 2, Halimulati Abuduwaili 3, Hein Ko Oo 3, Qifang Li 3, Cynthia M Galicia-Medina 3, Hiroaki Takayama 4, Kiyo-Aki Ishii 5, Yujiro Nakano 3, Yumie Takeshita 3, Tomohiro Iba 6, Hisamichi Naito 6, Masao Honda 7, Kenichi Harada 8, Yasuhiko Yamamoto 2, Toshinari Takamura 9 Am J Pathol . 2024/02/01
Conference Presentations
- MASLD/MASH as a possible diabetic vascular complication(conference： 第67回日本糖尿病学会年次学術集会)(2024/05/17)
- Molecular Pathophysiology Underlying MASH Complicated by Diabetes.(conference：International Congress on Obesity and Metabolic Syndrome)(2024/09/05)
Others
Arts and Fieldwork
Patent
Theme to the desired joint research
Grant-in-Aid for Scientific Research
○「糖尿病におけるバソプレシンの構造・機能変化と病態形成機序の解明」(2024-2027)
○「オキシトシンシグナルに着目した非アルコール性脂肪肝炎治療の開発へ向けた基盤研究」(2024-2027)
Competitive research funding,Contribution
Collaborative research,Consignment study
Classes (Bachelors)
○Medical Examination and Clinical Reasoning(2022)
○Roundup Lectures(2022)
○Roundup Lectures(2022)
Classes (Graduate Schools)
○Intoduction to Medicine Endocrinology and Metabolism(2024)