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Researcher Information

last modified：2024/11/21

Professor　TANIGUCHI, Hiroaki

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Faculty, Affiliation

Cancer Research Institute
Professor

College and School Educational Field


Laboratory

Division of Innovative Cancer Control Research (Clinical Oncology)　TEL:076-265-2794

Academic Background

Career

Kanazawa University Hospital　Clinical Oncology　chief(2024/09-)
Cancer Research Institute of Kanazawa University　Division of Innovative Cancer Control Research　Professor(2024/08-)
Osaka University　Graduate School of Medicine Division of Health Sciences, Department of Molecular Pathology(2023/07-)
(2019/05-2024/07)
University of Tsukuba(2019/04-)
Keio University　School of Medicine, Clinical and Translational Research Center(2018/11-2022/03)
The University of Tokyo　The Institute of Medical Science(2019/05-)
The University of Tokyo　The Institute of Medical Science(2018/04-2019/03)
The University of Tokyo　The Institute of Medical Science(2015/05-2018/03)
The University of Tokyo　The Institute of Medical Science(2012/07-2015/06)
The University of Tokyo　The Institute of Medical Science(2011/07-2012/06)
The University of Tokyo　The Institute of Medical Science(2011/04-2011/06)
Sapporo Medical University(2009/04-2011/03)
IDIBELL (Bellvitge Institute for Biomedical Research; Spain, Barcelona）(2008/11-2009/03)
(2007/04-2008/10)
Sapporo Medical University(2006/04-2007/03)
Sapporo Medical University　Hospital(2001/04-2002/03)

Year & Month of Birth

Academic Society












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Specialities

Tumor therapeutics、Tumor biology、Experimental pathology、Drug development chemistry、General internal medicine (including psychosomatic medicine)、Gastroenterology、Biomedical engineering/Biomaterial science and engineering

Speciality Keywords

oligonucleotide theraputics,molecular target therapy,cellular biology,molecular biology,cancer biology

Research Themes

Books

Papers

  • 　Genetic and epigenetic profiling in early colorectal tumors and prediction of invasive potential in pT1 (early invasive) colorectal cancers　Katsuhiko Nosho,Hiroyuki Yamamoto,Taiga Takahashi,Masashi Mikami,Hiroaki Taniguchi,Nobuki Miyamoto,Yasushi Adachi,Yoshiaki Arimura,Fumio Itoh,Kohzoh Imai,Yasuhisa Shinomura　CARCINOGENESIS　28　6　1364　2007/06
  • 　Association of matrilysin-2 (MMP-26) expression with tumor progression and activation of MMP-9 in esophageal squamous cell carcinoma　H Yamamoto,A Vinitketkumnuen,Y Adachi,H Taniguchi,T Hirata,N Miyamoto,K Nosho,A Imsumran,M Fujita,M Hosokawa,Y Hinoda,K Imai　CARCINOGENESIS　25　12　2353　2004/12
  • 　Interplay of insulin-like growth factor-II, insulin-like growth factor-I, insulin-like growth factor-I receptor, COX-2, and matrix metalloproteinase-7, play key roles in the early stage of colorectal carcinogenesis　K Nosho,H Yamamoto,H Taniguchi,Y Adachi,Y Yoshida,Y Arimura,T Endo,Y Hinoda,K Imai　CLINICAL CANCER RESEARCH　10　23　7950　2004/12
  • 　Characterization of the immune escape phenotype of human gastric cancers with and without high-frequency microsatellite instability　T. Hirata,H. Yamamoto,H. Taniguchi,S. Horiuchi,M. Oki,Y. Adachi,K. Imai,Y. Shinomura　JOURNAL OF PATHOLOGY　211　5　516　2007/04
  • 　Frequent epigenetic inactivation of Wnt inhibitory factor-1 in human gastrointestinal cancers　H Taniguchi,H Yamamoto,T Hirata,N Miyamoto,M Oki,K Nosho,Y Adachi,T Endo,K Imai,Y Shinomura　ONCOGENE　24　53　7946　2005/11

show all

  • 　Association of Ets-related transcriptional factor E1AF expression with overexpression of matrix metalloproteinases, COX-2 and iNOS in the early stage of colorectal carcinogenesis　K Nosho,M Yoshida,H Yamamoto,H Taniguchi,Y Adachi,M Mikami,Y Hinoda,K Imai　CARCINOGENESIS　26　5　892　2005/05
  • 　Expression of ets-related transcriptional factor E1AF is associated with tumor progression and over-expression of matrilysin in human gastric cancer　H Yamamoto,S Horiuchi,Y Adachi,H Taniguchi,K Nosho,YF Min,K Imai　CARCINOGENESIS　25　3　325　2004/03
  • 　Transcriptional silencing of Dickkopf gene family by CpG island hypermethylation in human gastrointestinal cancer　Tadateru Maehata,Hiroaki Taniguchi,Hiroyuki Yamamoto,Katsuhiko Nosho,Yasushi Adachi,Nobuki Miyamoto,Chie Miyamoto,Noriyuki Akutsu,Satoshi Yamaoka,Fumio Itoh　WORLD JOURNAL OF GASTROENTEROLOGY　14　17　2702　2008/05
  • 　Flat-type colorectal advanced adenomas (laterally spreading tumors) have different genetic and epigenetic alterations from protruded-type advanced adenomas　Taiga Takahashi,Katsuhiko Nosho,Hiroyuki Yamamoto,Masashi Mikami,Hiroaki Taniguchi,Nobuki Miyamoto,Yasushi Adachi,Fumio Itoh,Kohzoh Imai,Yasuhisa Shinomura　MODERN PATHOLOGY　20　1　139　2007/01
  • 　Mutational analysis of beta-catenin and the RAS-RAF signalling pathway in early flat-type colorectal tumours　Masashi Mikami,Katsuhiko Nosho,Hiroyuki Yamamoto,Taiga Takahashi,Tadateru Maehata,Hiroaki Taniguchi,Yasushi Adachi,Akimichi Imamura,Masahiro Fujita,Masao Hosokawa,Fumio Itoh,Kohzoh Imai,Yasuhisa Shinomura　EUROPEAN JOURNAL OF CANCER　42　17　3065　2006/11
  • 　Association of trypsin expression with tumour progression and matrilysin expression in human colorectal cancer　H Yamamoto,S Iku,Y Adachi,A Imsumran,H Taniguchi,K Nosho,YF Min,S Horiuchi,M Yoshida,F Itoh,K Imai　JOURNAL OF PATHOLOGY　199　2　176　2003/02
  • 　Transcriptional silencing of hedgehog-interacting protein by CpG hypermethylation and chromatic structure in human gastrointestinal cancer　H. Taniguchi,H. Yamamoto,N. Akutsu,K. Nosho,Y. Adachi,K. Imai,Y. Shinomura　JOURNAL OF PATHOLOGY　213　2　131　2007/10
  • 　Differential expression of angiogenesis-related genes in human gastric cancers with and those without high-frequency microsatellite instability　Nobuki Miyamoto,Hiroyuki Yamamoto,Hiroaki Taniguchi,Chie Miyamoto,Mariko Oki,Yasushi Adachi,Kohzoh Imai,Yasuhisa Shinomura　CANCER LETTERS　254　1　42　2007/08
  • 　Overexpression of poly(ADP-ribose) polymerase-1 (PARP-1) in the early stage of colorectal carcinogenesis　Katsuhiko Nosho,Hiroyuki Yamamoto,Masashi Mikami,Hiroaki Taniguchi,Taiga Takahashi,Yasushi Adachi,Akimichi Imamura,Kohzoh Imai,Yasuhisa Shinomura　EUROPEAN JOURNAL OF CANCER　42　14　2374　2006/09
  • 　An updated review of gastric cancer in the next-generation sequencing era: Insights from bench to bedside and vice versa　Hiroyuki Yamamoto,Yoshiyuki Watanabe,Tadateru Maehata,Ryo Morita,Yoshihito Yoshida,Ritsuko Oikawa,Shinya Ishigooka,Shun-ichiro Ozawa,Yasumasa Matsuo,Kosuke Hosoya,Masaki Yamashita,Hiroaki Taniguchi,Katsuhiko Nosho,Hiromu Suzuki,Hiroshi Yasuda,Yasuhisa Shinomura,Fumio Itoh　WORLD JOURNAL OF GASTROENTEROLOGY　20　14　3927　2014/04
  • 　The RNA-binding protein HuR regulates DNA methylation through stabilization of DNMT3b mRNA　Isabel Lopez de Silanes,Myriam Gorospe,Hiroaki Taniguchi,Kotb Abdelmohsen,Subramanya Srikantan,Miguel Alaminos,Mara Berdasco,Roco G. Urdinguio,Mario F. Fraga,Filipe V. Jacinto,Manel Esteller　NUCLEIC ACIDS RESEARCH　37　8　2658　2009/05
  • 　[An overview of antibody therapy against cancer].　Taniguchi H,Imai K　Nihon rinsho. Japanese journal of clinical medicine　70　12　2087　2012/12
  • 　Correlation of laterally spreading type and JC virus with methylator phenotype status in colorectal adenoma　Katsuhiko Nosho,Hiroyuki Yamamoto,Taiga Takahashi,Masashi Mikami,Keiichi Hizaki,Tadateru Maehata,Hiroaki Taniguchi,Satoshi Yamaoka,Yasushi Adachi,Fumio Itoh,Kohzoh Imai,Yasuhisa Shinomura　HUMAN PATHOLOGY　39　5　767　2008/05
  • 　Overexpression of the receptor tyrosine kinase EphA4 in human gastric cancers　Mariko Oki,Hiroyuki Yamamoto,Hiroaki Taniguchi,Yasushi Adachi,Kohzoh Imai,Yasuhisa Shinomura　WORLD JOURNAL OF GASTROENTEROLOGY　14　37　5650　2008/10
  • 　Genetic and epigenetic characteristics of gastric cancers with JC virus T-antigen　Satoshi Yamaoka,Hiroyuki Yamamoto,Katsuhiko Nosho,Hiroaki Taniguchi,Yasushi Adachi,Shigeru Sasaki,Yoshiaki Arimura,Kohzoh Imai,Yasuhisa Shinomura　WORLD JOURNAL OF GASTROENTEROLOGY　15　44　5579　2009/11
  • 　Silencing of Kruppel-like factor 2 by the histone methyltransferase EZH2 in human cancer　H. Taniguchi,F. V. Jacinto,A. Villanueva,A. F. Fernandez,H. Yamamoto,F. J. Carmona,S. Puertas,V. E. Marquez,Y. Shinomura,K. Imai,M. Esteller　ONCOGENE　31　15　1988　2012/04
  • 　The effect of IGF-I receptor blockade for human esophageal squamous cell carcinoma and adenocarcinoma　Yasushi Adachi,Hirokazu Ohashi,Arisa Imsumran,Hiroyuki Yamamoto,Yasutaka Matsunaga,Hiroaki Taniguchi,Katsuhiko Nosho,Hiromu Suzuki,Yasushi Sasaki,Yoshiaki Arimura,David P. Carbone,Kohzoh Imai,Yasuhisa Shinomura　TUMOR BIOLOGY　35　2　973　2014/02
  • 　Cancer detection by ubiquitin carboxyl-terminal esterase L1 methylation in pancreatobiliary fluids　Norihiro Kato,Hiroyuki Yamamoto,Yasushi Adachi,Hirokazu Ohashi,Hiroaki Taniguchi,Hiromu Suzuki,Mayumi Nakazawa,Hiroyuki Kaneto,Shigeru Sasaki,Kohzoh Imai,Yasuhisa Shinomura　WORLD JOURNAL OF GASTROENTEROLOGY　19　11　1718　2013/03
  • 　Interrelationship between microsatellite instability and microRNA in gastrointestinal cancer　Hiroyuki Yamamoto,Yasushi Adachi,Hiroaki Taniguchi,Hiroaki Kunimoto,Katsuhiko Nosho,Hiromu Suzuki,Yasuhisa Shinomura　WORLD JOURNAL OF GASTROENTEROLOGY　18　22　2745　2012/06
  • 　Insulin-like growth factor receptor expression is associated with aggressive phenotypes and has therapeutic activity in biliary tract cancers　Hirokazu Ohashi,Yasushi Adachi,Hiroyuki Yamamoto,Hiroaki Taniguchi,Katsuhiko Nosho,Hiromu Suzuki,Yoshiaki Arimura,Kohzoh Imai,David P. Carbone,Yasuhisa Shinomura　CANCER SCIENCE　103　2　252　2012/02
  • 　Insulin-like growth factor receptor expression is associated with aggressive phenotypes and has therapeutic activity in biliary tract cancers　Hirokazu Ohashi,Yasushi Adachi,Hiroyuki Yamamoto,Hiroaki Taniguchi,Katsuhiko Nosho,Hiromu Suzuki,Yoshiaki Arimura,Kohzoh Imai,David P. Carbone,Yasuhisa Shinomura　Cancer Science　103　2　252　2012/02
  • 　The Efficacy of IGF-I Receptor Monoclonal Antibody against Human Gastrointestinal Carcinomas is Independent of k-ras Mutation Status　Masanori Ii,Hua Li,Yasushi Adachi,Hiroyuki Yamamoto,Hirokazu Ohashi,Hiroaki Taniguchi,Yoshiaki Arimura,David P. Carbone,Kohzoh Imai,Yasuhisa Shinomura　CLINICAL CANCER RESEARCH　17　15　5048　2011/08
  • 　[Prevention of tumour invasion].　Daisuke Hoshino,Naohiko Koshikawa,Motoharu Seiki,Hiroaki Taniguchi　Nihon rinsho. Japanese journal of clinical medicine　70 Suppl 8　154　2012/11
  • 　Epigenetic inactivation of calcium-sensing receptor in colorectal carcinogenesis　Keiichi Hizaki,Hiroyuki Yamamoto,Hiroaki Taniguchi,Yasushi Adachi,Mayumi Nakazawa,Tokuma Tanuma,Norihiro Kato,Yasutaka Sukawa,Jose V. Sanchez,Hiromu Suzuki,Shigeru Sasaki,Kohzoh Imai,Yasuhisa Shinomura　MODERN PATHOLOGY　24　6　876　2011/06
  • 　Association of glypican-3 expression with growth signaling molecules in hepatocellular carcinoma　Noriyuki Akutsu,Hiroyuki Yamamoto,Shigeru Sasaki,Hiroaki Taniguchi,Yoshiaki Arimura,Kohzoh Imai,Yasuhisa Shinomura　WORLD JOURNAL OF GASTROENTEROLOGY　16　28　3521　2010/07
  • 　Co-expression of laminin beta 3 and gamma 2 chains and epigenetic inactivation of laminin alpha 3 chain in gastric cancer　Masanori II,Hiroyuki Yamamoto,Hiroaki Taniguchi,Yasushi Adachi,Mayumi Nakazawa,Hirokazu Ohashi,Tokuma Tanuma,Yasutaka Sukawa,Hiromu Suzuki,Shigeru Sasaki,Kohzoh Imai,Yasuhisa Shinomura　INTERNATIONAL JOURNAL OF ONCOLOGY　39　3　593　2011/09
  • 　A DNA methylation fingerprint of 1628 human samples　Agustin F. Fernandez,Yassen Assenov,Jose Ignacio Martin-Subero,Balazs Balint,Reiner Siebert,Hiroaki Taniguchi,Hiroyuki Yamamoto,Manuel Hidalgo,Aik-Choon Tan,Oliver Galm,Isidre Ferrer,Montse Sanchez-Cespedes,Alberto Villanueva,Javier Carmona,Jose V. Sanchez-Mut,Maria Berdasco,Victor Moreno,Gabriel Capella,David Monk,Esteban Ballestar,Santiago Ropero,Ramon Martinez,Marta Sanchez-Carbayo,Felipe Prosper,Xabier Agirre,Mario F. Fraga,Osvaldo Grana,Luis Perez-Jurado,Jaume Mora,Susana Puig,Jaime Prat,Lina Badimon,Annibale A. Puca,Stephen J. Meltzer,Thomas Lengauer,John Bridgewater,Christoph Bock,Manel Esteller　GENOME RESEARCH　22　2　407　2012/02
  • 　Epigenetic Inactivation of the Circadian Clock Gene BMAL1 in Hematologic Malignancies　Hiroaki Taniguchi,Agustin F. Fernandez,Fernando Setien,Santiago Ropero,Esteban Ballestar,Alberto Villanueva,Hiroyuki Yamamoto,Kohzoh Imai,Yasuhisa Shinomura,Manel Esteller　CANCER RESEARCH　69　21　8447　2009/11
  • 　Overexpression of beta 3/gamma 2 chains of laminin-5 and MMP7 in biliary cancer　Toshikuni Oka,Hiroyuki Yamamoto,Shigeru Sasaki,Masanori Ii,Keiichi Hizaki,Hiroaki Taniguchi,Yasushi Adachi,Kohzoh Imai,Yasuhisa Shinomura　WORLD JOURNAL OF GASTROENTEROLOGY　15　31　3865　2009/08
  • 　SARS-CoV-2 RT-qPCR testing of pooled saliva samples: A case study of 824 asymptomatic individuals and a questionnaire survey in Japan.　Junna Oba,Hiroaki Taniguchi,Masae Sato,Masaki Takanashi,Moe Yokemura,Yasunori Sato,Hiroshi Nishihara　PloS one　17　5　e0263700　2022/05
  • 　PRDM14 directly interacts with heat shock proteins HSP90α and glucose-regulated protein 78　Chiharu Moriya,Hiroaki Taniguchi,Satoru Nagatoishi,Hisayoshi Igarashi,Kouhei Tsumoto,Kohzoh Imai　Cancer Science　109　2　373　2018/02/01
  • 　PRDM14, a Zinc Finger Protein, Regulates Cancer Stemness.　Taniguchi H,Imai K　Methods in molecular biology (Clifton, N.J.)　1867　3　2018
  • 　Antitumoral RNA‐targeted oligonucleotide therapeutics: The third pillar after small molecule inhibitors and antibodies　Hiroaki Taniguchi,Yasunori Suzuki,Kohzoh Imai,Yasushi Adachi　Cancer Science　2022/07/11　
  • 　PRDM14 silencing by siRNA combined with an innovative nanoparticle reduced breast tumor formation and metastasis in vivo.　Taniguchi H,Moriya C,Akinaga S,Kataoka K,Imai K　Cancer Res　78　2018
  • 　Treatment of primary and metastatic breast and pancreatic tumors upon intravenous delivery of a PRDM14-specific chimeric siRNA/nanocarrier complex.　Hiroaki Taniguchi,Yukikazu Natori,Yohei Miyagi,Kotaro Hayashi,Fumitaka Nagamura,Kazunori Kataoka,Kohzoh Imai　International journal of cancer　149　3　646　2021/08/01
  • 　Silencing PRDM14 via Oligonucleotide Therapeutics Suppresses Tumorigenicity and Metastasis of Breast Cancer.　Hiroaki Taniguchi,Kohzoh Imai　Methods in molecular biology (Clifton, N.J.)　1974　233　2019　
  • 　Silencing PRDM14 expression by an innovative RNAi therapy inhibits stemness, tumorigenicity, and metastasis of breast cancer　Hiroaki Taniguchi,Daisuke Hoshino,Chiharu Moriya,Hitoshi Zembutsu,Nobuhiro Nishiyama,Hiroyuki Yamamoto,Kazunori Kataoka,Kohzoh Imai　ONCOTARGET　8　29　46856　2017/07
  • 　Inhibition of PRDM14 expression in pancreatic cancer suppresses cancer stem-like properties and liver metastasis in mice　Chiharu Moriya,Hiroaki Taniguchi,Kanjiro Miyata,Nobuhiro Nishiyama,Kazunori Kataoka,Kohzoh Imai　CARCINOGENESIS　38　6　638　2017/06
  • 　Cancer stem cells in human gastrointestinal cancer　Hiroaki Taniguchi,Chiharu Moriya,Hisayoshi Igarashi,Anri Saitoh,Hiroyuki Yamamoto,Yasushi Adachi,Kohzoh Imai　CANCER SCIENCE　107　11　1556　2016/11
  • 　Proteolysis of EphA2 Converts It from a Tumor Suppressor to an Oncoprotein　Naohiko Koshikawa,Daisuke Hoshino,Hiroaki Taniguchi,Tomoko Minegishi,Taizo Tomari,Sung-Ouk Nam,Mikiko Aoki,Takayuki Sueta,Takashi Nakagawa,Shingo Miyamoto,Kazuki Nabeshima,Alissa M. Weaver,Motoharu Seiki　CANCER RESEARCH　75　16　3327　2015/08
  • 　PRDM14 promotes malignant phenotype and correlates with poor prognosis in colorectal cancer　H. Igarashi,H. Taniguchi,K. Nosho,K. Ishigami,H. Koide,K. Mitsuhashi,K. Okita,I. Takemasa,K. Imai,H. Nakase　Clinical and Translational Oncology　22　7　1126　2020/07　
  • 　Knockdown of 15-bp Deletion-Type v-raf Murine Sarcoma Viral Oncogene Homolog B1 mRNA in Pancreatic Ductal Adenocarcinoma Cells Repressed Cell Growth In Vitro and Tumor Volume In Vivo　Jiaxuan Song,Yoshiaki Kobayashi,Yoshimasa Asano,Atsushi Sato,Hiroaki Taniguchi,Kumiko Ui-Tei　Cancers　14　13　3162　2022/06/28　
  • 　PRDM14 is overexpressed in chronic pancreatitis prior to pancreatic cancer.　Moriya C,Imai K,Taniguchi H　FEBS open bio　8　10　1733　2018/10
  • 　Therapeutic siRNA targeting the cancer cell stemness regulator PRDI-BF1 and RIZ domain zinc finger protein 14　Kohzoh IMAI,Hiroaki TANIGUCHI　Proceedings of the Japan Academy, Series B　98　7　325　2022/07/29　
  • 　RT-PCR Screening Tests for SARS-CoV-2 with Saliva Samples in Asymptomatic People: Strategy to Maintain Social and Economic Activities while Reducing the Risk of Spreading the Virus.　Junna Oba,Hiroaki Taniguchi,Masae Sato,Reika Takamatsu,Satoru Morikawa,Taneaki Nakagawa,Hiromasa Takaishi,Hideyuki Saya,Koichi Matsuo,Hiroshi Nishihara　The Keio journal of medicine　70　2　35　2021/06/25
  • 　The Evolving Landscape of Cancer Stem Cells and Ways to Overcome Cancer Heterogeneity.　Taniguchi H,Suzuki Y,Natori Y　Cancers　11　4　2019/04

Conference Presentations

Others

Arts and Fieldwork

Patent

Theme to the desired joint research

Grant-in-Aid for Scientific Research

○「多分子標的型核酸と高性能化DDSによって転移性癌をリセットするムーンショット計画」(2024-2026)　
○「癌幹細胞性を担うPRDM14分子の蛋白質相互作用に基づく機能解明と抗腫瘍薬の開発 」(2016-2018)　
○「新規がん幹細胞特異的マーカーの同定」(2013-2014)　
○「癌幹細胞を制御する転写因子を標的とした難治性乳癌治療法の開発」(2012-2014)　
○「大規模エピゲノム解析に基づく革新的消化器がん診断法の開発」(2011-2013)　
○「幹細胞様腫瘍細胞の形質を制御する新規経路の同定とがん治療への応用」(2011-2012)　

Competitive research funding,Contribution

Collaborative research,Consignment study

Classes (Bachelors)

Classes (Graduate Schools)

International Project

International Students

Lecture themes

Others (Social Activities)

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