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last modified：2025/04/02
Professor SAI Yoshimichi
Faculty, Affiliation
University Hospital Clinical Pharmacokinetics
College and School Educational Field
Division of Pharmaceutical Sciences, Graduate School of Medical Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences
School of Pharmacy, College of Medical, Pharmaceutical and Health Sciences
Department of Nursing，School of Health Sciences, College of Medical, Pharmaceutical and Health Sciences
Laboratory
Department of Hospital Pharmacy TEL:076-265-2045 FAX:076-234-4280
Academic Background
【Academic background(Doctoral/Master's Degree)】
Kanazawa University Doctor Graduate School, Division of National Science and Technology (except Gakushuin University, Konan University) 199403 Completed
Kanazawa University Master Graduate School, Division of Pharmaceutical Sciences 199103 Completed
【Academic background(Bachelor's Degree)】
Kanazawa University 1989
【Degree】
Ph.D.
Career
2014- Kanazawa University Hospital, Professor University Hospital Director of Department of Hospital Pharmacy(2014/05/01-)
2009-2014 Kanazawa University Hospital, Associate Professor University Hospital(2009/01/01-2014/04/30)
2008-2008 Faculty of Pharmacy, Keio University, Associate Professor Faculty of Pharmacy Associate Professor(2008/04/01-2008/12/31)
2004-2008 Department of Pharmacy, Kyoritsu University of Pharmacy Associate Professor Department of Pharmacy Associate Professor(2004/04/01-2008/03/31)
2000-2004 Graduate School of Natural Science and Technology, Kanazawa University, Research Associate Graduate School of Natl Sci and Technol(2000/04/01-2004/03/31)
1997-1999 School of Medicine, Tufts University Postdoctoral Fellow School of Medicine Postdoctoral Fellow(1997/09/01-1999/08/31)
1994-2000 Faculty of Pharmaceutical Sciences, Kanazawa University, Research Associate Faculty of Pharmaceutical Sciences(1994/04/01-2000/03/31)
Year & Month of Birth
1966/07
Academic Society
Japanese Society of Pharmaceutical Health Care and Sciences
Japanese Society of Pharmaceutical Health Care and Sciences
Japanese Society of Pharmaceutical Health Care and Sciences
The Academy of Pharmaceutical Science and Technology, Japan
The Academy of Pharmaceutical Science and Technology, Japan
The Academy of Pharmaceutical Science and Technology, Japan
The Academy of Pharmaceutical Science and Technology, Japan
Japanese Society for the Study of Xenobiotics
Award
Specialities
Clinical Pharmacology、Applied Pharmacology and Medical Pharmacology、Cell Biology
Speciality Keywords
Biopharmaceutics Applied Pharmacology and Medical Pharmacology Cell Biology
Research Themes
Biopharmaceutical Approach to Personalized Medicine
Books
- Expert's Guide 2021/03/31
- Expert's Guide 2020/03/30
- Expert's Guide 2018/03/24
Papers
- Sodium citrate buffer improves pazopanib solubility and absorption in gastric acid-suppressed rat model Muhammad HJ, Shimada T, Fujita A, Sai Y Drug Metab Pharmacokinet 55 1-5 2024/01/03
- Application site of transdermal scopolamine influences efficacy and drug concentration in salivary glands in rats. Natsuko Ishida, Yoshitaka Oshima, Ayano Katsura, Rikako Imamura, Hiroshi Arakawa, Tsutomu Shimada, Satoshi Mizuno, Yoshimichi Sai, Yukio Suga, Ryo Matsushita. Biol Pharm Bull 46 12 1805-1809 2023/12/01
- Association between switching prescribed drugs for lower urinary tract symptoms and independence of urination in post-stroke patients: A retrospective cohort study. Koyomi Sumiya,Miho Shogenji,Yasunori Ikenaga,Yoru Ogawa,Kohei Hirako,Arimi Fujita,Tsutomu Shimada,Masako Hashimoto,Akio Masuda,Takehito Nagamoto,Ikumi Tamai,Hisayuki Ogura,Tadashi Toyama,Takashi Wada,Yoshimichi Sai Journal of stroke and cerebrovascular diseases : the official journal of National Stroke Association 32 12 107419 2023/10/14
- Case report: therapeutic monitoring of vancomycin in an acute liver failure patient with anuria under high-flow continuous hemodiafiltration. Yuriko Ito,Junya Nakade,Akihiro Seki,Ryosuke Gabata,Mitsuyoshi Okazaki,Shinichi Nakanuma,Arimi Fujita,Tsutomu Shimada,Taro Yamashita,Shintaro Yagi,Takumi Taniguchi,Yoshimichi Sai Journal of pharmaceutical health care and sciences 9 1 15 2023/05/01
- Evaluation of factors affecting epidermal growth factor receptor tyrosine kinase inhibitor-induced hepatotoxicity in Japanese patients with non-small cell lung cancer: a two-center retrospective study. Hirofumi Nagai,Tsutomu Shimada,Yoshimitsu Takahashi,Mikako Nishikawa,Hiroyuki Tozuka,Yasuto Yamamoto,Osamu Niwa,Yutaka Takahara,Arimi Fujita,Katsuhiko Nagase,Kazuo Kasahara,Seiji Yano,Yoshimichi Sai Journal of pharmaceutical health care and sciences 8 1 28 2022/12/01
- Impact of antithymocyte globulin on blood cyclosporin A levels in aplastic anemia patients Yuya Futagi,Yukio Suga,Tsutomu Shimada,Yoshimichi Sai Annals of Hematology 102 2 463-465 2022/11/26
- Ceftriaxone-induced encephalopathy in a patient with a solitary kidney. Yuya Futagi,Yuriko Ito,Junya Nakade,Arimi Fujita,Tsutomu Shimada,Misaki Yoshida,Yoshinori Takahashi,Mitsuhiro Kawano,Takumi Taniguchi,Yoshimichi Sai International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases 122 722 2022/09
- Single-Center Analysis of Pegfilgrastim-induced Aortitis Using a Drug Prescription Database and CT Findings. Atsushi Takamatsu,Kotaro Yoshida,Fumihito Toshima,Kazuto Kozaka,Naho Yamamoto,Yoshimichi Sai,Toshifumi Gabata Radiology 305 3 220357 2022/08/09
- Relationship between Bowel/Bladder Function and Discharge in Older Stroke Patients in Convalescent Rehabilitation Wards: A Retrospective Cohort Study. Miho Shogenji,Mikako Yoshida,Koyomi Sumiya,Tsutomu Shimada,Yasunori Ikenaga,Yoru Ogawa,Kohei Hirako,Yoshimichi Sai Progress in rehabilitation medicine 7 20220028 2022
- Association of a continuous continence self-management program with independence in voiding behavior among stroke patients: a retrospective cohort study Miho Shogenji, Mikako Yoshida, Koyomi Sumiya, Tsutomu Shimada, Yasunori Ikenaga, Yoru Ogawa, Kohei Hirako, Yoshimichi Sai Neurourol Urodyn 41 4 2022/03/30
- Risk factors for interstitial lung disease induced by gemcitabine plus albumin-bound paclitaxel therapy in pancreatic ductal adenocarcinoma patients Rikako Ueda, Naho Yamamoto, Yuki Hori, Kouji Yoshida, Koushiro Ohtsubo, Takeshi Terashima, Tsutomu Shimada, Yoshimichi Sai. J Pharm Health Care Sci 8 1 1-8 2022/02/02
- Limited impact of murine placental MDR1 on fetal exposure of certain drugs explained by bypass transfer between adjacent syncytiotrophoblast layers. Arimi Fujita, Saki Noguchi, Rika Hamada, Satoko Inoue, Tsutomu Shimada, Satomi Katakura, Tetsuo Maruyama, Yoshimichi Sai, Tomohiro Nishimura, Masatoshi Tomi. Pharm Res 2022/01/03
- Initial serum C-reactive protein level as a predictor of increasing serum vancomycin concentration during treatment Kazuya Isoda, Junya Nakade; Yukio Suga; Tsutomu Shimada; Yoshimichi Sai, Suga Y, Shimada T, Sai Y. TDM 43 5 652-656 2021/10
- Oxytocin-Trust Link in Oxytocin-Sensitive Participants and Those without Autistic Traits Yusuke Kinari, Hirofumi Kurokawa, Hiroko Okudaira, Kiyotaka Tsubouchi, Yoshimichi Sai, Mitsuru Kikuchi, Haruhiro Higashida, Fumio Ohtake Frontiers in Neuroscience 15 659737 1-13 2021/05/25
- Administration of erlotinib in apple juice overcomes decreased absorption in a rat model of gastric acid suppression Shimada T, Okano M, Yamada M, Ogawa Y, Ueda A, Nagase K, Sai Y. Drug Metab Pharmacokinet 35 6 534-538 2020/12
- Risk Factors for Delayed Elimination of Methotrexate in Children, Adolescents and Young Adults With Osteosarcoma Misaka KO, Suga Y, Staub Y, Tsubata A, Shimada T, Sai Y, Matsushita R. In Vivo 34 6 3459-3465 2020/11
- Comparison of Tolerability Between 2-Weekly and 3-Weekly Docetaxel Regimen in Castration-resistant Prostate Cancer Shimura Y, Suga Y, Itai S, Iwamoto H, Takezawa Y, Yaegashi H, Izumi K, Shimada T, Sai Y, Matsushita R, Mizokami A. Anticancer Res 40 8 4291-4297 2020/08
- Competitiveness and individual characteristics: a double-blind placebo-controlled study using oxytocin. Kurokawa H, Kinari Y, Okudaira H, Tsubouchi K, Sai Y, Kikuchi M, Higashida H, Ohtake F. Sci Rep 10 1 11526 2020/07/13
- Examination of Aggregate Formation upon Simultaneous Dissolution of Methacrylic Acid Copolymer LD Enteric Coating Agent, Pharmaceutical Additives, and Zwitterionic Ingredients. Nakagawa Y, Suzuki T, Suga Y, Shimada T, Sai Y. Biol Pharm Bull 43 4 682-687 2020/04
- A previously unknown drug-drug interaction is suspected in delayed elimination of plasma methotrexate in high-dose methotrexate therapy. Ishizaki J, Nakano C, Kitagawa K, Suga Y, Sai Y Ann Pharmacother 54 1 29-35 2020/01
- Detailed assessment and risk factor analysis of corticosteroid-induced psychiatric disorders in pediatric, adolescent, and young adult patients undergoing induction or consolidation therapy for hematologic malignancy. Yukiko Staub, Yukio Suga, Yasuhiro Ikawa, Kiyotaka Tsubouchi, Mikie Hashimoto, Atsufumi Kawagishi, Tsutomu Shimada, Yoshimichi Sai, Katsuji Nishimura, Ryo Matsushita. J Oncol Pharm Pract 1-11 2019/10/21
- Improvement of informed consent document management in clinical trials using an electronic medical record system. Takahiro Kawakami, Katsuhiko Nagase, Yuko Yokoi, Yoshimichi Sai, Toshinori Murayama Jpn J Clin Pharmacol Ther 50 3 81-86 2019/05
- Incidence and risk factors of neonatal hypoglycemia after ritodrine therapy in premature labor: a retrospective cohort study. Shoko Shimokawa*, Akiko Sakata*, Yukio Suga, Kazuya Isoda, Shingo Itai, Katsuhiko Nagase, Tsutomu Shimada, Yoshimichi Sai J Pharm Health Care Sci 5 7 1-7 2019/04/16
- Palonosetron on Days 1 and 5 Versus Granisetron Daily (Days 1-5) in Germ Cell Tumour Therapy. Shimura Y, Izumi K, Itai S, Iwamoto H, Yaegashi H, Suga Y, Shimada T, Mizokami A, Sai Y. In Vivo 33 2 643-647 2019/04
- Risk Factors for Peripheral Neuropathy Induced by Albumin-bound Paclitaxel Plus Gemcitabine Therapy in Pancreatic Cancer Patients N Yamamoto, Y Hori, R Takahiro, Y Suga, T Shimada, Y Sai Japanese Journal of Pharmaceutical Health Care and Sciences 45 3 127-134 2019/03
- Multiday corticosteroids in cancer chemotherapy delay the diagnosis of and antimicrobial administration for febrile neutropenia: a double-center retrospective study. Hiroki Uda, Yukio Suga, Eriko Toriba, Angelina Yukiko Staub, Tsutomu Shimada, Yoshimichi Sai, Masami Kawahara, Ryo Matsushita J Pharm Health Care Sci 5 3 1-8 2019/02/04
- Effect of coadministration of rifampicin on the pharmacokinetics of linezolid: clinical and animal studies. Satsuki Hashimoto, Kyoko Honda, Kouhei Fujita, Yuka Miyachi, Kazuya Isoda1, Ko Misaka, Yukio Suga, Satoshi Kato, Hiroyuki Tsuchiya, Yukio Kato, Masaki Okajima, Takumi Taniguchi, Tsutomu Shimada, Yoshimichi Sai J Pharm Health Care Sci 4 27 1-9 2018/11/12
- Risk factors for oxaliplatin-induced vascular pain in patients with colorectal cancer and comparison of the efficacy of preventive methods. Yukio Suga, Nana Ikeda, Manami Maeda, Angelina Yukiko Staub, Tsutomu Shimada, Miwa Yonezawa, Hironori Kitade, Hideyuki Katsura, Morihiro Okada, Junko Ishizaki, Yoshimichi Sai and Ryo Matsushita J Pharm Health Care Sci 4 18 1-7 2018/08/07
- Incidence and risk factors of cholinergic syndromes induced by FOLFILINOX in advanced pancreatic adenocarcinoma Tomoyo Ito, Junya Nakade, Tsutomu Shimada Yoshimichi Sai Japanese Journal of Pharmaceutcal Healthcare and Sciences 44 8 403-409 2018/08
- Contribution of equilibrative nucleoside transporters 1 and 2 to gemcitabine uptake in pancreatic cancer cells. Hioki M, Shimada T, Yuan T, Nakanishi T, Tajima H, Yamazaki M, Yokono R, Takabayashi M, Sawamoto K, Akashita G, Miyamoto KI, Ohta T, Tamai I, Shimada T, Sai Y. Biopharm Drug Dispos 39 256-264 2018/04/22
- Multiple Oral Dosing Pharmacokinetics of Standardized Extract of Centella asiatica ECa 233 and Its Inductive Effect on Efflux Transporters in Rat Tosapol Anukunwithaya, Mayuree H. Tantisira, Tsutomu Shimada, Yoshimichi Sai, Phisit Khemawoot Planta Medica International Open 4 e66-e73 2017/10/11
- Drug Safety Management and Pharmacist Sai Yoshimichi Journal of Pharmaceutical Science and Technology, Japan 77 3 117 2017
- Drug interaction between methotrexate and salazosulfapyridine in Japanese patients with rheumatoid arthritis Morihiro Okada, Hiroshi Fujii, Yukio Suga, Satoshi Morito, Masae Okada, Jun Nishigami, Mitsuhiro Kawano, Tsutomu Shimada, Yoshimichi Sai J Pharm Health Care Sci 3 7 1-7 2017/01/19
- Co-administration of dexamethasone increases severity and accelerates onset day of neutropenia in bladder cancer patients on methotrexate, vinblastine, adriamycin and cisplatin chemotherapy: a retrospective cohort study Shingo Itai, Yukio Suga, Yusuke Hara, Kouji Izumi, Yuji Maeda, Yasuhide Kitagawa, Junko Ishizaki, Tsutomu Shimada, Atsushi Mizokami and Yoshimichi Sai J Pharm Health Care Sci 3 3 1-6 2017/01/11
- Aggregation in a Suspension of Lansoprazole OD Tablets and Levofloxacin Hydrate Tablets in Water Nakgawa Y,Suzuki T,Shimura Y,Suga Y,Shimada T,Sai Y Jpn J Pharm Health Care Sci. 43 1 26 2017/01
- Oxytocin for male subjects with autism spectrum disorder and comorbid intellectual disabilities: A randomized pilot study Toshio Munesue, Hiroyuki Nakamura, Mitsuru Kikuchi, Yui Miura, Noriyuki Takeuchi, Tokie Anme, Eiji Nanba, Kaori Adachi, Kiyotaka Tsubouchi, Yoshimichi Sai, Kenichi Miyamoto, Shinichi Horike, Shigeru Yokoyama, Hideo Nakatani, Hirotaka Kosaka, Yoshio Minabe, Haruhiro Higashida Frontiers Psyc 7 2 2016/01/21
- BIPHASIC HEPATIC UPTAKE OF GEMCITABINE CHARACTERIZED BY CONTRIBUTION OF ENT1 AND ENT2 Shimada Takuya,Yamazaki Maiko,Yokono Rina,Sawamoto Kazuki,Takabayashi Makiko,Tajima Hidehiro,Nakanishi Takeo,Miyamoto Ken-ichi,Tamai Ikumi,Sai Yoshimichi DRUG METABOLISM REVIEWS 47 246 2015/11/20
- PK/PD analysis of biapenem in patients undergoing continuous hemodiafiltration Akashita G, Hosaka Y, Noda T, Isoda K, Shimada T, Sawamoto K, Miyamoto K, Taniguchi T, Sai Y. J Pharm Health Care Sci 1 31 2015/11/14
- Effect of switching basal insulin regimen to degludec on quality of life in Japanese patients with type 1 and type 2 diabetes mellitus Okada Mo, Okada Ma, Nishigami J, Yamaaki N, Furukawa K, Ohyama K, Shimada T, Sai Y. J Pharm Health Care Sci 1 26 2015/09/30
- Saturable hepatic extraction of gemcitabine involves biphasic uptake mediated by nucleoside transporters equilibrative nucleoside transporter 1 and 2. Shimada T, Nakanishi T, Tajima H, Yamazaki M, Yokono R, Takabayashi M, Shimada T, Sawamoto K, Miyamoto K, Kitagawa H, Ohta T, Tamai I, Sai Y. J Pharm Sci 104 9 3162-3169 2015/06/02
- Long-term follow-up of post hematopoietic stem cell transplantation for Hurler syndrome: clinical, biochemical, and pathological improvements Yasuda E, Mackenzie W, Ruhnke K, Shimada T, Mason RW, Zustin J, Martin PL, Thacker M, Orii T, Sai Y, Tomatsu S. Mol Genet Metab Rep 2 65-76 2015/03/02
- Glycogen synthase kinase 3β sustains invasion of glioblastoma via the focal adhesion kinase, Rac1 and c-Jun N-terminal kinase-mediated pathway Chikano Y, Domoto T, Furuta T, Sabit H, Kitano-Tamura A, Pyko IV, Takino T, Sai Y, Hayashi Y, Sato H, Miyamoto K, Nakada M, Minamoto T. Mol Cancer Ther 14 2 564-574 2015/02
- Pharmacokinetics of docetaxel during hyperthermic intraperitoneal chemotherapy for peritoneal metastasis Yonemura Y, Canbay E, Sako S, Ishibashi H, Hirano M, Mizumoto A, Takeshita K, Takao N, Ichinose M, Liu Y, Li Y, Ikeda S, Noguchi A, Sai Y. Jpn J Cancer Chemother 41 12 2496-2499 2014/11
- Salacia reticulata has therapeutic effects on obesity. Tsutomu Shimada,Yuichiro Nakayama,Yukiko Harasawa,Hirofumi Matsui,Hiroko Kobayashi,Yoshimichi Sai,Ken-ichi Miyamoto,Shunji Tomatsu,Masaki Aburada J Nat Med 68 4 668-766 2014/10
- Fetal growth retardation and lack of hypotaurine in ezrin knockout mice. Nishimura T, Higuchi K, Sai Y, Sugita Y, Yoshida Y, Tomi M, Wada M, Wakayama T, Tamura A, Tsukita S, Soga T, Nakashima E. PLoS ONE 21 9 e105423 2014/08
- Mechanisms of lower maintenance dose of tacrolimus in obese patients. Sawamoto K, Huong TT, Sugimoto N, Mizutani Y, Sai Y, Miyamoto KI. Drug Metab Phrmacokinet 29 4 341-347 2014/08
- Mechanisms of Lower Maintenance Dose of Tacrolimus in Obese Patients Kazuki Sawamato,Tran T. Huong,Natsumi Sugimoto,Yuka Mizutani,Yoshimichi Sai,Ken-ichi Miyamoto DRUG METABOLISM AND PHARMACOKINETICS 29 4 341 2014/08
- System A amino acid transporter SNAT2 shows subtype-specific affinity for betaine and hyperosmotic inducibility in placental trophoblasts. Nishimura T, Yagi R, Usuda M, Oda K, Yamazaki M, Suda S, Okazaki F, Sai Y, Higuchi K, Maruyama T, Tomi M, Nakashima E. Biochim Biophys Acta (Biomembrane) 1838 5 1306-1312 2014/05
- Basic fibroblast growth factor is essential to maintain endothelial progenitor cell phenotype in TR-BME2 cells Sai Y, Nishimura T, Muta M, Iizasa H, Miyata T, Nakashima E. Biol Pharm Bull 37 4 688-693 2014/04
- Enantioselective disposition of clenbuterol in rats. Hirosawa I, Ishikawa M, Ogino M, Ito H, Hirano T, Yamada H, Asahi M, Kotaki H, Sai Y, Miyamoto KI. Biopharm Drug Dispos 35 4 207-217 2014/04
- Ligand-dependent EphB1 signaling suppresses glioma invasion and correlates with patient survival. Teng L, Nakada M, Furuyama N, Sabit H, Furuta T, Hayashi Y, Takino T, Dong Y, Sato H, Sai Y, Miyamoto KI, Berens ME, Zhao SG, Hamada JI. Neuro Oncol 2013/11
- Hepatic arterial infusion chemotherapy with gemcitabine for patients with postoperative liver metastases from pancreatic cancer Tajima H, Kitagawa H, Shoji M, Okamoto K, Nakanuma S, Sakai S, Kinoshita J, Makino I, Hayashi H, Nakamura K, Oyama K, Nakagawara H, Miyashita T, Takamura H, Ohta T, Minami T, Koda W, Sanada J, Gabata T, Sai Y. 40 12 1668-1671 2013/11
- Involvement of carnitine/organic cation transporter OCTN1/SLC22A4 in gastrointestinal absorption of metformin. Nakamichi N,Shima H,Asano S,Ishimoto T,Sugiura T,Matsubara K,Kusuhara H,Sugiyama Y,Sai Y,Miyamoto K,Tsuji A,Kato Y JOURNAL OF PHARMACEUTICAL SCIENCES 102 9 3407-17 2013/09
- Evaluation of rat in vivo fetal-to-maternal transfer clearances of various xenobiotics by umbilical perfusion. Nishimura T,Takanohashi T,Tomi M,Horikoshi M,Higuchi K,Sai Y,Nakashima E JOURNAL OF PHARMACEUTICAL SCIENCES 102 9 3356-63 2013/09
- Estrogen receptor α induction by mitoxantrone increases Abcg2 expression in placental trophoblast cells. Oda K,Nishimura T,Higuchi K,Ishido N,Ochi K,Iizasa H,Sai Y,Tomi M,Nakashima E JOURNAL OF PHARMACEUTICAL SCIENCES 102 9 3364-72 2013/09
- Hepatic arterial infusion chemotherapy with gemcitabine and 5‑fluorouracil or oral S‑1 improves the prognosis of patients with postoperative liver metastases from pancreatic cancer Hidehiro Tajima, Hirohisa Kitagawa, Tomoya Tsukada, Koichi Okamoto, Shin‑Ichi Nakanuma, Seisho Sakai, Isamu Makino, Hiroyuki Furukawa, Hironori Hayashi, Katsunobu Oyama, Masafumi Inokuchi, Hisatoshi Nakagawara, Tomoharu Miyashita, Hiroshi Itoh, Hideto Fujita, Hiroyuki Takamura, Itasu Ninomiya, Sachio Fushida, Takashi Fujimura, Tetsuo Ohta, Wataru Koda, Tetsuya Minami, Yasuji Ryu, Junichiro Sanada, Toshifumi Gabata, Osamu Matsui, Yoshimichi Sai Mol Clin Oncol 1 5 869-874 2013/09
- Estrogen Receptor α Induction by Mitoxantrone Increases Abcg2 Expression in Placental Trophoblast Cells. Oda K,Nishimura T,Higuchi K,Ishido N,Ochi K,Iizasa H,Sai Y,Tomi M,Nakashima E Journal of Pharmaceutical Science 102 9 3364 2013/09
- Involvement of Carnitine/Organic Cation Transporter OCTN1/SLC22A4 in Gastrointestinal Absorption of Metformin Nakamichi Noritaka,Shima Hiroyo,Asano Satoshi,Ishimoto Takahiro,Sugiura Tomoko,Matsubara Kazuki,Kusuhara Hiroyuki,Sugiyama Yuichi,Sai Yoshimichi,Miyamoto Ken-Ichi,Tsuji Akira,Kato Yukio JOURNAL OF PHARMACEUTICAL SCIENCES 102 9 3407 2013/09
- Mechanism of nucleoside uptake in rat placenta and induction of placental CNT2 in experimental diabetes. Nishimura T,Chishu T,Tomi M,Nakamura R,Sato K,Kose N,Sai Y,Nakashima E Drug Metab Pharmacokinet 27 4 439-46 2013/08
- Integrin α3 is overexpressed in glioma stem-like cells and promotes invasion. Nakada M,Nambu E,Furuyama N,Yoshida Y,Takino T,Hayashi Y,Sato H,Sai Y,Tsuji T,Miyamoto KI,Hirao A,Hamada JI BRITISH JOURNAL OF CANCER 108 12 2516-24 2013/06
- Aberrant glycogen synthase kinase 3β is involved in pancreatic cancer cell invasion and resistance to therapy. Kitano A,Shimasaki T,Chikano Y,Nakada M,Hirose M,Higashi T,Ishigaki Y,Endo Y,Takino T,Sato H,Sai Y,Miyamoto K,Motoo Y,Kawakami K,Minamoto T PLoS One 8 2 e55289 2013/02
- Influence of long-term enteral nutrition on pharmacokinetics of digoxin in rats. Higashi K,Tanaka C,Imanishi K,Sawamoto K,Horikawa T,Ohkawa H,Matsushita R,Sai Y,Miyamoto K Drug Metab Pharmacokinet 28 1 44-52 2013/02
- Pharmacokinetic analysis for proper use of drugs in obese, enteral nutrition and other patients 121 4 167-171 2012/12
- Puerariae flos alleviates metabolic diseases in Western diet-loaded, spontaneously obese type 2 diabetic model mice Kubo K, Shimada T, Onishi R, Tsubata M, Kamiya T, Nagamine R, Iizuka S, Sai Y, Amagaya S, Aburada M, Miyamoto KI J Nat Med 66 4 622-630 2012/10
- Pharmacist-based Donepezil Outpatient Consultation Service to improve medication persistence. Watanabe N,Yamamura K,Suzuki Y,Umegaki H,Shigeno K,Matsushita R,Sai Y,Miyamoto K,Yamada K Patient Prefer Adherence 6 605-611 2012/08
- Mechanism of nucleoside uptake in rat placenta and induction of placental CNT2 in experimental diabetes Nishimura Tomohiro,Chishu Takuya,Tomi Masatoshi,Nakamura Ryo,Sato Kazuko,Kose Noriko,Sai Yoshimichi,Nakashima Emi Drug Metabolism and Pharmacokinetics 27 4 439 2012/08
- Change in pharmacokinetics of mycophenolic acid as a function of age in rats and effect of coadministered amoxicillin/clavulanate. Ishizaki J,Tsuda T,Suga Y,Ito S,Arai K,Sai Y,Miyamoto K Biol Pharm Bull 35 7 1009-13 2012/07
- CCR5 plays a critical role in obesity-induced adipose tissue inflammation and insulin resistance by regulating both macrophage recruitment and M1/M2 status. Kitade H,Sawamoto K,Nagashimada M,Inoue H,Yamamoto Y,Sai Y,Takamura T,Yamamoto H,Miyamoto K,Ginsberg HN,Mukaida N,Kaneko S,Ota T DIABETES 61 7 1680-90 2012/07
- Disposition kinetics of taxanes in peritoneal dissemination. Miyamoto K,Shimada T,Sawamoto K,Sai Y,Yonemura Y Gastroenterol Res Pract 2012 963403 2012/05
- Elimination of teicoplanin by adsorption to the filter membrane during haemodiafiltration: screening experiments for linezolid, teicoplanin and vancomycin followed by in vitro haemodiafiltration models for teicoplanin. Shiraishi Y,Okajima M,Sai Y,Miyamoto K,Inaba H Anaesth Intensive Care 40 3 442-9 2012/05
- Evaluation of safety in clinical use of generic paclitaxel [NK] for injection. Tsukiyama I,Hotta K,Takeuchi M,Onishi M,Toyama Y,Saito H,Sai Y,Miyamoto K,Hasegawa T Jpn J Cancer Chemother 39 4 613-7 2012/04
- Flavangenol (pine bark extract) and its major component procyanidin B1 enhance fatty acid oxidation in fat-loaded models. Shimada T,Tokuhara D,Tsubata M,Kamiya T,Kamiya-Sameshima M,Nagamine R,Takagaki K,Sai Y,Miyamoto K,Aburada M EUROPEAN JOURNAL OF PHARMACOLOGY 677 1-3 147-53 2012/02
- Endoplasmic reticulum stress inhibits STAT3-dependent suppression of hepatic gluconeogenesis via dephosphorylation and deacetylation. Kimura K,Yamada T,Matsumoto M,Kido Y,Hosooka T,Asahara S,Matsuda T,Ota T,Watanabe H,Sai Y,Miyamoto K,Kaneko S,Kasuga M,Inoue H DIABETES 61 1 61-73 2012/01
- Investigation for relation of gustatory and olfactory impairment in patients receiving cancer chemotherapy Yukio Suga,Hironori Kitade,Atsufumi Kawagishi,Kazuyoshi Takeda,Kazunobu Haruki,Junko Ishizaki,Yoshimichi Sai,Kazuo Kasahara,Kunizo Arai,Ken-Ichi Miyamoto Japanese Journal of Cancer and Chemotherapy 38 13 2617 2011/12/15
- [Investigation for relation of gustatory and olfactory impairment in patients receiving cancer chemotherapy] Suga Y,Kitade H,Kawagishi A,Takeda K,Haruki K,Ishizaki J,Sai Y,Kasahara K,Arai K,Miyamoto K Gan To Kagaku Ryoho 38 13 2617-21 2011/12
- Preventive effect of geniposide on metabolic disease status in spontaneously obese type 2 diabetic mice and free fatty acid-treated HepG2 cells. Kojima K,Shimada T,Nagareda Y,Watanabe M,Ishizaki J,Sai Y,Miyamoto K,Aburada M Biol Pharm Bull 34 10 1613-8 2011/10
- Enhancement of zidovudine transfer to molt-4 cells, a human t-cell model, by dehydroepiandrosterone sulfate. Nishimura T,Tanaka J,Tomi M,Seki Y,Kose N,Sai Y,Nakashima E J Pharm Sci 100 9 3959-67 2011/09
- 6-Mercaptopurine transport by equilibrative nucleoside transporters in conditionally immortalized rat syncytiotrophoblast cell lines TR-TBTs. Lee NY,Sai Y,Nakashima E,Ohtsuki S,Kang YS JOURNAL OF PHARMACEUTICAL SCIENCES 100 9 3773-82 2011/09
- A randomized, quadruple crossover single-blind study on immediate action of chewed and unchewed low-dose acetylsalicylic acid tablets in healthy volunteers. Sai Y,Kusaka A,Imanishi K,Matsumoto M,Takahashi R,Sugimoto N,Sugama J,Anada T,Asakura H,Miyamoto K JOURNAL OF PHARMACEUTICAL SCIENCES 100 9 3884-91 2011/09
- A Randomized, Quadruple Crossover Single-Blind Study on Immediate Action of Chewed and Unchewed Low-Dose Acetylsalicylic Acid Tablets in Healthy Volunteers Yoshimichi Sai,Akiyo Kusaka,Kaori Imanishi,Manami Matsumoto,Rie Takahashi,Natsumi Sugimoto,Junko Sugama,Takako Anada,Hidesaku Asakura,Ken-Ichi Miyamoto JOURNAL OF PHARMACEUTICAL SCIENCES 100 9 3884 2011/09
- Enhancement of zidovudine transfer to Molt-4 cells, a human T-cell model, by dehydroepiandrosterone sulfate Nishimura Tomohiro,Tanaka Jun,Tomi Masatoshi,Seki Yoshiaki,Kose Noriko,Sai Yoshimichi,Nakashima Emi JOURNAL OF PHARMACEUTICAL SCIENCES 100 9 3959 2011/09
- mTORC1 activation triggers the unfolded protein response in podocytes and leads to nephrotic syndrome. Ito N,Nishibori Y,Ito Y,Takagi H,Akimoto Y,Kudo A,Asanuma K,Sai Y,Miyamoto KI,Takenaka H,Yan K LABORATORY INVESTIGATION 91 11 1584-1595 2011/08
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- Salacia reticulata inhibits differentiation of 3T3-L1 adipocytes. Shimada T,Nagai E,Harasawa Y,Watanabe M,Negishi K,Akase T,Sai Y,Miyamoto K,Aburada M J Ethnopharmacol 136 1 67-74 2011/06
- Preventive effects of Salacia reticulata on non-alcoholic fatty liver disease (NAFLD)/ non-alcoholic steatohepatitis (NASH) in monosodium glutamate treated mice. 101. Watanabe M, Shimada T, Iiduka S, Iida N, Kojima K, Ishizaki J, Sai Y, Miyamoto KI, Aburada M J Trad Med 28 2 73-82 2011/05
- Protecting cisplatin-induced nephrotoxicity with cimetidine does not affect antitumor activity. Katsuda H,Yamashita M,Katsura H,Yu J,Waki Y,Nagata N,Sai Y,Miyamoto K Biol Pharm Bull 33 11 1867-71 2010/11
- Roles of TauT and system A in cytoprotection of rat syncytiotrophoblast cell line exposed to hypertonic stress. Nishimura T,Sai Y,Fujii J,Muta M,Iizasa H,Tomi M,Deureh M,Kose N,Nakashima E PLACENTA 31 11 1003-9 2010/11
- Proton-coupled erythromycin antiport at rat blood-placenta barrier. Sai Y,Nishimura T,Ochi K,Tanaka N,Takagi A,Tomi M,Kose N,Kobayashi Y,Miyakoshi N,Kitagaki S,Mukai C,Nakashima E Drug Metab Dispos 38 9 1576-81 2010/09
- Differential expression of ezrin and CLP36 in the two layers of syncytiotrophoblast in rats. Higuchi K,Iizasa H,Sai Y,Horieya S,Lee KE,Wada M,Deguchi M,Nishimura T,Wakayama T,Tamura A,Tsukita S,Kose N,Kang YS,Nakashima E Biol Pharm Bull 33 8 1400-6 2010/08
- Surfactants influence the distribution of taxanes in peritoneal dissemination tumor-bearing rats. Kamijo Y, Ito C, Nomura M, Sai Y, Miyamoto KI Cancer Lett 287 2 182-186 2010/01
- Effect of low-dose paclitaxel and docetaxel on endothelial progenitor cell Muta M, Yanagawa T, Sai Y, Saji S, Suzuki E, Aruga T, Kuroi K, Matsumoto G, Toi M, Nakashima E Oncology 77 3-4 182-191 2009/09
- Expression, localization and binding activity of the ezrin/radixin/moesin proteins in the mouse testis Wakayama T, Nakata H, Kurobo M, Sai Y, Iseki S J Histochem Cytochem 57 4 351-362 2009/04
- Influx mechanism of 2’, 3’-dideoxyinosine (ddI) and uridine at the blood-placenta barrier. Sato K, Sai Y, Nishimura T, Chishu T, Kose N, Nakashima E. PLACENTA 30 3 263-269 2009/03
- Enhancement of zidovudine uptake by dehydroepiandrosterone sulfate in rat syncytiotrophoblast cell line TR-TBT 18d-1. Nishimura T, Seki Y, Sato K, Chishu T, Kose N, Terasaki T, Kang YS, Sai Y, Nakashima E. DRUG METABOLISM AND DISPOSITION 36 10 2080-2085 2008/10
- Characterization of the mechanism of Zidovudine uptake by rat conditionally immortalized syncytiotrophoblast cell line TR-TBT. Sai Y, Nishimura T, Shimpo S, Chishu T, Sato K, Kose N, Terasaki T, Mukai C, Miyakoshi N, Kang YS, Nakashima E. PHARMACEUTICAL RESEARCH 25 7 1647-1653 2008/07
- Involvement of carnitine/organic cation transporter OCTN2 (SLC22A5) in distribution of its substrate carnitine to the heart Iwata D, Kato Y, Wakayama T, Sai Y, Kubo Y, Iseki S, Tsuji A Drug Metab Pharmacokinet 23 3 207-215 2008/06
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- Heterophilic binding of the adhesion molecules poliovirus receptor and immunoglobulin superfamily 4A in the interaction between mouse spermatogenic and Sertoli cells Wakayama T, Sai Y, Ito A, Kato Y, Murakami Y, Nakashima E, Tsuji A, Kitamura Y, Iseki S BIOLOGY OF REPRODUCTION 76 1081-1090 2007/02
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- Organic cation/carnitine transporter octn2 (slc22a5) is responsible for carnitine transport across apical membranes of small intestinal epithelial cells in mouse Kato Y, Sugiura M, Sugiura T, Wakayama T, Kubo Y, Kobayashi D, Sai Y, Tamai I, Iseki S, Tsuji A MOLECULAR PHARMACOLOGY 70 3 829-837 2006/09
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- International comparison of educational systems for OTC drugs in pharmacy schools Tsukiji M, Isawa M, Kose N, Rigod JF, Sai Y, Nakashima E Jpn J Drug Inform 8 1 6-12 2006/05
- Carrier-mediated hepatic uptake of a novel non-renal excretion type uric acid generation inhibitor, Y-700 Sai Y, Kato Y, Nakamura K, Kato S, Nishimura T, Kubo Y, Tamai I, Yang S, Hu Z, Yamada I, Tsuji A J Pharm Sci 95 2 336-347 2006/02
- Characterization of the transdermal transport of flurbiprofen and indomethacin Li Q, Tsuji H, Kato Y, Sai Y, Kubo Y, Tsuji A J Control Release 110 3 542-556 2006/02
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- Multidrug resistance associated protein 1 (MRP1) functions as an efflux pump of xenobiotics in the skin Li Q, Kato Y, Sai Y, Tsuji A Pharm Res 22 6 842-846 2005/06
- Prediction of theophylline clearance in CCl4-treated rats using in vivo CYP1A2 and CYP3A2 contents assessed with the PKCYP test Kose N, Yamamoto K, Sai Y, Isawa M, Suwa T, Nakashima E Drug Metab Pharmacokinet 20 3 168-176 2005/06
- Platelet-derived dgrowth factor-BB (PDGF-BB) induces differentiation of bone marrow endothelial progenitor cell-derived cell line TR-BME2 into mural cells, and changes the phenotype Miyata T, Iizasa H, Sai Y, Fujii J, Terasaki T, Nakashima E J Cell Physiol 204 3 948-955 2005/04
- Biochemical and molecular pharmacological aspects of transporters as determinants of drug disposition Yoshimichi Sai Drug Metab Pharmacokinet 20 2 91-99 2005/04
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- Functional characterization of human organic cation transporter OCTN1: single nucleotide polymorphisms in the Japanese population Kawasaki Y, Kato Y, Sai Y, Tsuji A J Pharm Sci 93 12 2920-2926 2004/12
- Screening of the interaction between xenobiotic transporters and PDZ proteins Kato Y, Yoshida K, Watanabe C, Sai Y, Tsuji A Pharm Res 21 10 1886-1894 2004/10
- Characterization of renal excretion mechanism for a novel diuretic, M71500, in rats Nishimura T, Kato Y, Sai Y, Ogihara T, Tsuji A J Pharm Sci 93 10 2558-2566 2004/10
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- Functional regions of organic cation/carnitine transporter OCTN2 (SLC22A5): Roles in carintine recognistion Inano A, Sai Y, Kato Y, Tamai I, Ishiguro M, Tsuji A. Drug Metab Pharmacokinet 19 3 180-189 2004/06
- Transporter-mediated renal handling of nafamostat mesilate Li Q, Sai Y, Kato Y, Muraoka H, Tamai I, Tsuji A J Pharm Sci 93 2 262-272 2004/02
- Involvement of OCTN1 (SLC22A4) in pH-dependent transport of organic cations Tamai I, Nakanishi T, Kobayashi D, China K, Kosugi Y, Nezu J, Sai Y, Tsuji A Mol Pharm 1 1 57-66 2004/01
- The genetic polymorphism of drug transporters: Functional analysis approaches Ishikawa T, Tsuji A, Inui K, Sai Y, Anzai N, Wada M, Endou H, Sumino Y Pharmacogenomics 5 1 67-99 2004/01
- Involvement of multiple transport systems in the disposition of an active metabolite of a prodrug-type new quinolone antibiotic, Prulifloxacin Yagi Y, Shibutani S, Hodoshima N, Ishiwata K, Okudaira N, Li Q, Sai Y, Kato Y, Tsuji A Drug Metab Pharmacokinet 18 6 381-389 2003/12
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- Influence of drugs and nutrients on transporter gene expression levels in Caco-2 and LS180 intestinal epithelial cell lines Li Q, Sai Y, Kato Y, Tamai I, Tsuji A Pharm Res 20 8 1119-1124 2003/08
- Experimental demonstration of the unstirred water layer effect on drug transport in Caco-2 cells JOURNAL OF PHARMACEUTICAL SCIENCES 92 7 1502-1508 2003/07
- Contribution of organic anion transporting polypeptide analogue [D-Ala2, D-Leu5]-enkephalin Nozawa T, Tamai I, Sai Y, Nezu J, Tsuji A J Pharm Pharmacol 55 7 1013-1020 2003/07
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- Expression and functional characterization of the adhesion molecule spermatogenic immunoglobulin superfamily in the mouse testis BIOLOGY OF REPRODUCTION 68 5 1755-1763 2003/05
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- The Mechanism by which cAMP Activates Phosphoinositide 3-Kinase and Increases Bile Acid Secretion in WIF-B9 Cells AMERICAN JOURNAL OF PHYSIOLOGY-CELL PHYSIOLOGY 283 C1655-1666 2002/08
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- Salacia reticulata inhibits differentiation of 3T3-L1 adipocytes Tsutomu Shimada,Eiichi Nagai,Yukiko Harasawa,Michiru Watanabe,Kenichi Negishi,Tomoko Akase,Yoshimichi Sai,Ken-ichi Miyamoto,Masaki Aburada JOURNAL OF ETHNOPHARMACOLOGY 136 1 67 2011/06
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- Differential expression of ezrin and CLP36 in the two layers of syncytiotrophoblast in rats. Higuchi K,Iizasa H,Sai Y,Horieya S,Lee KE,Wada M,Deguchi M,Nishimura T,Wakayama T,Tamura A,Tsukita S,Kose N,Kang YS,Nakashima E Biological & pharmaceutical bulletin 33 8 1400 2010
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- Na+-dependent carnitine transport is mediated by multifunctional OCTN transporter family Tamai, I,R Ohashi,K Sakamoto,J Nezu,A Oku,Y Sai,M Shimane,A Tsujil CONTROL AND DISEASES OF SODIUM DEPENDENT TRANSPORT PROTEINS AND ION CHANNELS 1208 323 2000
- Design and synthesis of peptides passing through the blood-brain barrier. Bull. Chem. Soc. Jpn. 71 699-709 1998
- Transdermal pilocarpine on the skin over salivary glands to increase salivation: An in vivo study Natsuko Ishida, Ayano Katsura, Koichi Takagaki, Hiroshi Arakawa, Tsutomu Shimada, Satoshi Mizuno, Yoshimichi Sai, Yukio Kato, Hiroyuki Nakamura, Yukio Suga, Ryo Matsushita BMC Oral Health 24 1 881 2024/08/02
- Effect of obesity on pharmacokinetics of transdermal fentanyl: Single-center retrospective study and animal study Satoshi Mizuno, Shintaro Gake, Makiko Takabayashi, Yuriko Ito, Hiroko Sanada, Natsumi Sugimoto, Akari Maeda, Takuto Tamamura, Kazuki Sawamoto, Yusuke Hara, Yoshiko Ohi, Chiaki Tsuji, Yukiko Shiomoto, Yukio Kato, Arimi Fujita, Tsutomu Shimada, Ken-ichi Miyamoto, Yoshimichi Sai. Drug Metab Pharmacokinet 60 101035 2024/11/05
- Effect of changes in skin properties due to diabetes mellitus on the titration period of transdermal fentanyl: single-center retrospective study and diabetic animal model study Satoshi Mizuno; Makiko Takabayashi; Hiroko Makihara; Kazuhiro Ogai; Kei Tsukui; Yuriko Ito; Takahiro Kawakami; Yusuke Hara; Arimi Fujita; Yoshihiro Tokudome; Tomoko Akase; Yukio Kato; Tsutomu Shimada; Yoshimichi Sai J Pharm Health Care Sci 10 80 2024/12/18
- Validation of an automated sample preparation module directly connected to LC-MS/MS (CLAM-LC-MS/MS system) and comparison with conventional immunoassays for quantitation of tacrolimus and cyclosporin A in a clinical setting Tsutomu Shimada, Daisuke Kawakami, Arimi Fujita, Rintaro Yamamoto, Satoshi Hara, Kiyoaki Ito, Ichiro Mizushima, Shinji Kitajima, Yasunori Iwata, Norihiko Sakai, Mitsuhiro Kawano, Takashi Wada, Yoshimichi Sai J Pharm Health Care Sci 10 5 1-7 2024/01/08
Conference Presentations
- Analysis of drug-endogenous substrate interactions using in vitro and in vivo methods(conference：26th 2024 ISSX-39th JSSX Joint Meeting)(2024/09/23)
- Alteration in intercellular lipid composition of stratum corneum in Goto-Kakizaki rats: a model of type 2 diabetes with an increased fentanyl release ratio from the transdermal formulation(conference：26th 2024 ISSX-39th JSSX Joint Meeting)(2024/09/23)
- Comparative Pharmacokinetic Profiles of Favipiravir Alone and in Combination with Thai Herbs Extract in Rats(conference：26th 2024 ISSX-39th JSSX Joint Meeting)(2024/09/23)
- （2017.6.9、） (2017/06/09)
- Recent Review of Cardiotoxicity of Target Therapies and Anticancer Drugs(conference：The 81st Annual Scientific Meeting of the Japanese Circulation Society 2017)(2017/03/18)
- Pharmacokinetic analysis of intravenous administrerd fentanyl in adjuvant induced arthritis rat(2017/11/29)
- Effect of obesity on disposition of tacrolimus and cutaenous fentanyl(conference：28th Annual Meeting of Japanese Society for the Study of Xenobiotics)(2013/10/09)
- 88. 2022/7/15 Zoomを用いたオンライン配信 （金沢市/三重県） （第一三共） 「」 (2022/07/15)
- To Clarify Mechanism of Neonatal hypoglycemia by ritodrine(2021/10/24)
- The comparison of the MDR1 contribution to the drug distribution of the placental barrier and blood-brain barrier(2021/10/24)
- 第209回例会 特別講演 （山口県病院薬剤師会(2024/03/24)
- Effect of soluble dietary fiber on decreased digoxin blood concentration in patients with long term semi-digested nutrition(2017/11/29)
- A longitudinal survey on urinary independence and prescription trends in post-stroke patients(conference：ACCP 2022, The 21st Asian Conference on Clinical Pharmacy)(2022/02/11)
- Long-term administration of Elental® affects the pharmacokinetic parameters of oral tacrolimus in rats(conference：ACCP 2022, The 21st Asian Conference on Clinical Pharmacy)(2022/02/11)
- 100. 2022/3/21 ステーションカンファレンス東京 （東京都千代田区） WEBと会場のハイブリッド 「地域における効果的な薬剤師確保の取組に関する調査研究」 (2023/03/21)
Others
- 【病気とくすり2018 基礎と実践Expert's Guide】血液・造血器系の病気とくすり 血栓塞栓症、播種性血管内凝固症候群 朝倉 英策,菅 幸生,崔 吉道 薬局 69 4 1066 2018/03
Arts and Fieldwork
Patent
Theme to the desired joint research
○Development of Drug Screening Format for Transporters
○Active Delivery of Drugs by in vivo Heterologous Expression of Transporters
○Development of Transporter-Aided Artificial Organs
Grant-in-Aid for Scientific Research
○「共焦点レーザー顕微鏡を用いたペプチドの細胞内動態解析と脳実質細胞標的化への応用」(1995-1995)
○「外来性遺伝子発現系を用いた小腸上皮薬物担体輸送機構の解明」(1995-1995)
○「ダイナミックインターフェースとしての血液脳関門機能と薬物脳移行相関」(1995-1996)
○「小腸オリゴペプチド輸送体の組織及び細胞内分布の免疫化学的解析と薬物輸送特性」(1996-1996)
○「モノカルボン酸系の組織特異的機能発現とドラックデリバリーへの応用」(1996-1996)
○「小腸モノカルボン酸輸送体の組織及び細胞内分布の免疫化学的解析と薬物輸送の分子機構」(1997-1998)
○「血液脳関門トランスポーターの分子機構と薬物の脳移行制御」(1997-1998)
○「トランスポーター発現アデノウイルスベクターを用いたペプチド様抗がん剤の脳腫瘍送達」(2000-2000)
○「ペプチドトランスポーターを利用した腫瘍特異的抗がん剤デリバリー」(2000-2001)
○「ペプチド輸送系の組織特異的発現と分子認識多様性を利用した腫瘍選択的薬物デリバリー」(2000-2001)
○「血液脳関門の機能的実態解明に基づいた薬物中枢移行性評価法の確立」(2000-2001)
○「薬物トランスポーター群の分子認識・輸送の多様性に基づいた臓器移行性の制御」(2000-2002)
○「BBB指向性トランスポーター発現アデノウイルスベクターを用いた抗がん剤脳腫瘍送達」(2001-2001)
○「薬物トランスポーター群のMultispecificity発現機構に関する研究」(2001-2002)
○「アンチセンス発現アデノウイルスを用いたトランスポーターの薬物体内動態制御機能評価」(2002-2003)
○「薬物輸送トランスポーターの迅速同定システムの構築とその寄与の推定」(2004-2005)
○「脳血管内皮細胞、周皮細胞、星状細胞が関わる血液能関門における基底膜維持機構の解明」(2004-2005)
○「トランスポーター活性アレイを用いた胎盤関門異物認識の全容解明」(2006-2007)
○「胎盤関門のダイナミクスを制御するトランスポーター－エズリン複合体」(2008-2010)
○「副作用マネジメントと毒性回避のための臨床薬物動態研究」(2011-2014)
○「腹膜偽粘液腫の本邦における発生頻度・病態の解明・治療法の開発」(2013-2013)
○「肥満時の薬物動態変動による医薬品副作用の回避戦略」(2015-2018)
○「careとcureを融合した看護薬剤学モデルの開発」(2017-2021)
○「経皮吸収型製剤の皮膚透過に与える薬剤性皮膚機能変動の影響と網羅的メカニズムの解明」(2023-2025)
○「血液脳関門に発現するP-糖タンパクの機能低下による自殺企図メカニズムの解明」(2022-2024)
○2022「病態背景が経皮吸収型製剤の経皮アベイラビリティにおよぼす影響」(2020-2022)
○「加齢による薬物体内動態の個人間変動予測の新機軸」(2019-2022)
Competitive research funding,Contribution
Collaborative research,Consignment study
Classes (Bachelors)
○Basic and Clinical Pharmacology(2022)
○Safety Management for Drug Therapy(2022)
○Clinical Pharmacology(2022)
○Clinical Clerkship（Clinical Pharmacology）(2022)
○Pharmacy Practice 1(2022)
○Pharmacy Practice 2(2022)
○Seminar in Pharmacy 3(2021)
○Seminar in Pharmacy 2(2021)
○Graduation Research in Pharmacy 3(2021)
○Graduation Research in Pharmacy 2(2021)
○Clinical Pharmacology(2021)
○Clinical Pharmacy Practice(2021)
○Pharmacy Practice 3(2021)
○Pharmacy Practice 2(2021)
○Pharmacy Practice 1(2021)
○Safety Management for Drug Therapy(2021)
○Basic and Clinical Pharmacology(2021)
○Seminar in Pharmacy 3(2020)
○Seminar in Pharmacy 2(2020)
○Graduation Research in Pharmacy 3(2020)
○Graduation Research in Pharmacy 2(2020)
○Pharmacy Practice 4(2020)
○Pharmacy Practice 3(2020)
○Pharmacy Practice 1(2020)
○Clinical Pharmacy Practice(2020)
○Clinical Pharmacology(2020)
○Pharmacy Practice 2(2020)
○Safety Management for Drug Therapy(2020)
○Basic and Clinical Pharmacology(2020)
○Clinical Pharmacology(2019)
○Clinical Pharmacy Practice(2019)
○Hospital Pharmacy Practice 1(2019)
○Pharmacy Practice 2(2019)
○Safety Management for Drug Therapy(2019)
○Basic and Clinical Pharmacology(2019)
○Safety Management for Drug Therapy(2017)
○Pharmacology(BSL)(2017)
○Hospital Pharmacy Practice 1(2017)
○Basic and Clinical Pharmacology(2017)
○Community Pharmacy(2017)
○Hospital Pharmacy Practice 2(2017)
○Safety Management for Drug Therapy(2016)
○Basic and Clinical Pharmacology(2016)
○Pharmacology(BSL)(2016)
○Hospital Pharmacy Practice 1(2016)
○Hospital Pharmacy Practice 2(2016)
○Management of Community Pharmacy(2016)
Classes (Graduate Schools)
○Clinical Pharmacokinetics＆Informatics(2022)
○Medicinal Informatics(2022)
○Medicinal Informatics(2021)
○Molecular Mechanisms of Drug Response(2021)
○Medicinal Informatics(2021)
○Basic Training on Medical Researches(2021)
○Medicinal Informatics(2020)
○Medicinal Informatics(2020)
○Medicinal Informatics(2020)
○Intensive Lectures on Medical Researches(2020)
○Basic Training on Medical Researches(2020)
○Medicinal Informatics(2019)
○Medicinal Informatics(2019)
○Hospital Pharmacy Practice 1(2017)
○Medicinal Informatics(2017)
○Medicinal Informatics(2017)
○Medicinal Informatics(2017)
○Molecular Mechanisms of Drug Response(2017)
○Molecular Mechanisms of Drug Response(2016)
○Medicinal Informatics(2016)
○Medicinal Informatics(2016)
○Medicinal Informatics(2016)