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last modified：2025/04/02
Associate Professor KOBAYASHI Akira
Faculty, Affiliation
University Hospital Department of ophthalmology
College and School Educational Field
Division of Medicine, Graduate School of Medical Science
School of Medicine, College of Medical, Pharmaceutical and Health Sciences
Laboratory
TEL:076-265-2403 FAX:076-222-9660
Academic Background
【Academic background(Bachelor's Degree)】
Shiga University of Medical Science 1992
【Degree】
PhD
Career
Year & Month of Birth
Academic Society
American Academy of Ophthalmology
Japan Corneal Society
Japanese Ophthalmological Society
Japanese Society of Ophthalmology
Japanse Society of corneal transplatation
Japanese Society of Ophthalmic Surgery
Award
○Japan Ophthalomology Society Investigator Award(2007)
○Japan Cornea Society Promising Investigator Award(2008)
○Japan Cornea Society Promising Investigator Award(2008)
○Japan Cornea Society Promising Investigator Award(2008)
○Japan Cornea Society Promising Investigator Award(2008)
○Japan Cornea Society Promising Investigator Award(2008)
○Japan Cornea Society Promising Investigator Award(2008)
Specialities
Ophthalmology
Speciality Keywords
anterior segment optical coherence tomography,in vivo confocal microscopy of cornea,endothelial keratoplasty,keratoplasty,amniotic membrane transplantation
Research Themes
Basics and clinical practice of amnion transplant
development of corneal endothelial keratoplasty
in vivo confocal microscopic analysis of corneal disease
Books
- Amniotic membrane transplantation in acute phase of toxic epudermal necrolysis with severe corneal involvement American Academy of Ophthalmology 113 1 126-132 2006/01
- Akira Kobayashi , Mami Takahashi M, Kazuhisa Sugiyama Reliability of intraocular pressure by Tono-Pen XL over amniotic membrane patch in human. 13 413-416 2004
- Akira Kobayashi Amniotic membrane grafting for a conjunctival defect caused by multiple surgeries 36 47-49 2004
Papers
- In vivo histology and p.L132V mutation in KRT12 gene in Japanese patients with Meesmann corneal dystrophy. Nishino T, Kobayashi A, Mori N, Masaki T, Yokogawa H, Fujiki K, Yanagawa A, Murakami A, Sugiyama K Japanese journal of ophthalmology 63 1 46-55 2019
- Analysis of COL8A2 gene mutation in Japanese patients with Fuchs endothelial dystrophy and posterior polymorphous dystrophy. JAPANESE JOURNAL OF OPHTHALMOLOGY 48 3 195-198 2004/05
- A 10-year review of underlying diseases for endothelial keratoplasty (DSAEK/DMEK) in a tertiary referral hospital in Japan. Nishino T, Kobayashi A, Yokogawa H, Mori N, Masaki T, Sugiyama K Clinical ophthalmology 12 1359-1365 2018
- White-light and laser confocal microscopic findings of rabbit OPHTHALMIC SURGERY AND LASERS 35 2 146-148 2004/03
- Spontaneous reattachment of dislocated endothelial graft after non-Descemet stripping automated endothelial keratoplasty: a case report. Kodama-Takahashi A, Fukuda M, Sugioka K, Kobayashi A, Shimomura Y BMC ophthalmology 18 1 14 2018
- Indocyanine green staining for the triple corneal procedure. OPHTHALMIC SURGERY AND LASERS 35 1 23-25 2004/01
- In vivo confocal microscopy and genotyping of a family with Thiel-Behnke (honeycomb) corneal dystrophy. ARCHIVES OF OPHTHALMOLOGY 121 10 1498-1499 2003/10
- Clinical evaluation of a novel surgical technique (large cross incision) for conjunctival cysts. Nishino T, Kobayashi A, Mori N, Masaki T, Yokogawa H, Sugiyama K Canadian journal of ophthalmology. 53 1 e36-e39 2018
- Double-Bubble Technique in Descemet Membrane Endothelial Keratoplasty for Vitrectomized Eyes: A Case Series. Hayashi T, Kobayashi A Cornea 37 9 1185-1188 2018
- Combined Keratoplasty, Pars Plana Vitrectomy, and Flanged Intrascleral Intraocular Lens Fixation to Restore Vision in Complex Eyes With Coexisting Anterior and Posterior Segment Problems. Yokogawa H, Kobayashi A, Okuda T, Mori N, Masaki T, Sugiyama K Cornea 37 1 78-85 2018
- Idiopathic limbal squamous metaplasia. ARCHIVES OF OPHTHALMOLOGY 121 10 1473-1475 2003/10
- Development of a Donor Tissue Holding Technique for Descemet's Membrane Endothelial Keratoplasty Using a 25-Gauge Graft Manipulator. Kobayashi A, Yokogawa H, Mori N, Masaki T, Sugiyama K Case reports in ophthalmology 9 3 431-738 2018
- Clinical significance of owl eye morphologic features by in vivo laser confocal microscopy in patients with cytomegalovirus corneal endotheliitis Kobayashi, Akira; Yokogawa, Hideaki; Higashide, Tomomi; Nitta, Koji; Sugiyama, Kazuhisa American Journal of Ophthalmology 153 3 445-453 2012/03/01
- A case of bilateral descemet's membrane and subepithelial opacity: In vivo laser confocal microscopic study Hatta, Yukiko; Yokogawa, Hideaki; Kobayashi, Akira; Torisaki, Makoto; Sugiyama, Kazuhisa Case Reports in Ophthalmology 4 1 46-52 2013/01/01
- Evaluation of Internationally Shipped Prestripped Donor Tissue for Descemet Membrane Endothelial Keratoplasty by Vital Dye Staining Kobayashi, Akira; Murata, Noriaki; Yokogawa, Hideaki; Yamazaki, Natsuko; Masaki, Toshinori; Sugiyama, Kazuhisa Cornea 2014/12/17
- Endothelial keratoplasty with infant donor tissue Kobayashi, Akira; Yokogawa, Hideaki; Yamazaki, Natsuko; Masaki, Toshinori; Sugiyama, Kazuhisa Clinical Ophthalmology 8 1827-1830 2014/09/11
- Descemet's stripping and non-Descemet's stripping automated endothelial keratoplasty for microcornea using 6.0 mm donor grafts Yokogawa, Hideaki; Kobayashi, Akira; Yamazaki, Natsuko; Ueta, Yoshiki; Hashimoto, Yoshihiro; Tachi, Naoko; Sugiyama, Kazuhisa Clinical Ophthalmology 7 1951-1956 2013/09/27
- Ex vivo laser confocal microscopy findings of cultured Acanthamoeba trophozoites Yamazaki, Natsuko; Kobayashi, Akira; Yokogawa, Hideaki; Ishibashi, Yasuhisa; Oikawa, Yosaburo; Tokoro, Masaharu; Sugiyama, Kazuhisa Clinical Ophthalmology 6 1 1365-1368 2012/08/21
- Genetic characterization of clinical Acanthamoeba isolates from Japan using nuclear and mitochondrial small subunit ribosomal RNA Rahman, Md Moshiur; Yagita, Kenji; Kobayashi, Akira; Oikawa, Yosaburo; Hussein, Amjad I A; Matsumura, Takahiro; Tokoro, Masaharu Korean Journal of Parasitology 51 4 401-411 2013/08/01
- Descemet stripping automated endothelial keratoplasty for microcornea Toshida, Hiroshi; Ohta, Toshihiko; Murakami, Akira; Kobayashi, Akira; Sugiyama, Kazuhisa Japanese Journal of Ophthalmology 56 5 436-440 2012/09/01
- Bowman's layer encystment in cases of persistent Acanthamoeba keratitis Yokogawa, Hideaki; Kobayashi, Akira; Yamazaki, Natsuko; Ishibashi, Yasuhisa; Oikawa, Yosaburo; Tokoro, Masaharu; Sugiyama, Kazuhisa Clinical Ophthalmology 6 1 1245-1251 2012/08/01
- A sliding technique to load thin endothelial donor lamella onto Busin glide for Descemet-stripping automated endothelial keratoplasty Kobayashi, Akira; Yokogawa, Hideaki; Sugiyama, Kazuhisa Clinical Ophthalmology 6 1 1229-1231 2012/07/31
- Clinical evaluation of a new donor graft inserter for Descemet's stripping automated endothelial keratoplasty Yokogawa, Hideaki; Kobayashi, Akira; Sugiyama, Kazuhisa Ophthalmic Surgery Lasers and Imaging 43 1 50-56 2012/01/01
- Clinical results of the Neusidl Corneal Inserter? a new donor inserter for Descemet's stripping automated endothelial keratoplasty, for small Asian eyes Kobayashi, Akira; Yokogawa, Hideaki; Sugiyama, Kazuhisa Ophthalmic Surgery Lasers and Imaging 43 4 311-318 2012/07/01
- Clinical features of single and repeated globe rupture after penetrating keratoplasty Murata, Noriaki; Yokogawa, Hideaki; Kobayashi, Akira; Yamazaki, Natsuko; Sugiyama, Kazuhisa Clinical Ophthalmology 7 461-465 2013/03/04
- Clinical evaluation of non-Descemet stripping automated endothelial keratoplasty (nDSAEK) Masaki, Toshinori; Kobayashi, Akira; Yokogawa, Hideaki; Saito, Yoshiaki; Sugiyama, Kazuhisa Japanese Journal of Ophthalmology 56 3 203-207 2012/05/01
- Intraocular Pressure After Descemet's Stripping and Non-Descemet's Stripping Automated Endothelial Keratoplasty Mawatari, Yoshiro;Kobayashi, Akira;Yokogawa, Hideaki;Sugiyama, Kazuhisa JAPANESE JOURNAL OF OPHTHALMOLOGY 55 2 98-102 2011
- Evaluation of Internationally Shipped Prestripped Donor Tissue for Descemet Membrane Endothelial Keratoplasty by Vital Dye Staining Kobayashi, Akira;Murata, Noriaki;Yokogawa, Hideaki;Yamazaki, Natsuko;Masaki, Toshinori;Sugiyama, Kazuhisa CORNEA 34 2 225-227 2015/01/01
- The use of endoillumination probe-assisted descemet membrane endothelial keratoplasty for bullous keratopathy secondary to argon laser iridotomy Kobayashi, Akira; Yokogawa, Hideaki; Yamazaki, Natsuko; Masaki, Toshinori; Sugiyama, Kazuhisa Clinical Ophthalmology 9 91-93 2015/01/08
- Surgical therapies for corneal perforations: 10 years of cases in a tertiary referral hospital Yokogawa, Hideaki; Kobayashi, Akira; Yamazaki, Natsuko; Masaki, Toshinori; Sugiyama, Kazuhisa Clinical Ophthalmology 8 2165-2170 2014/10/29
- In Vivo Imaging of Coin-Shaped Lesions in Cytomegalovirus Corneal Endotheliitis by Anterior Segment Optical Coherence Tomography Yokogawa, Hideaki; Kobayashi, Akira; Yamazaki, Natsuko; Sugiyama, Kazuhisa Cornea 2014/10/02
- In vivo laser confocal microscopy findings of a cornea with osteogenesis imperfecta Kobayashi, Akira; Higashide, Tomomi; Yokogawa, Hideaki; Yamazaki, Natsuko; Masaki, Toshinori; Sugiyama, Kazuhisa Clinical Ophthalmology 8 429-433 2014/02/21
- Multicenter study of descemet membrane endothelial keratoplasty: First case series of 18 surgeons Monnereau, Claire; Quilendrino, Ruth; Dapena, Isabel; Liarakos, Vasilios S.; Alfonso, Jose F.; Arnalich-Montiel, Francisco; B?hnke, Matthias; Pereira, Nicolas Ces?rio; Dirisamer, Martin B.; Parker, John S.; Droutsas, Konstantinos D.; Geerling, Gerd; Gerten, Georg J.; Hashemi, Hassan; Kobayashi, Akira; Naveiras, Miguel; Oganesyan, Oganes; Domingo, Emeterio Ordu?a; Priglinger, Siegfried Georg; Stod?lka, Pavel; Silva, Jos? Torrano; Venzano, Davide; Vetter, Jan Markus; Yiu, Evan; Melles, Gerrit R J JAMA Ophthalmology 132 10 1192-1198 2014/01/01
- In vivo imaging of radial keratoneuritis in patients with acanthamoeba keratitis by anterior-segment optical coherence tomography Yamazaki, Natsuko; Kobayashi, Akira; Yokogawa, Hideaki; Ishibashi, Yasuhisa; Oikawa, Yosaburo; Tokoro, Masaharu; Sugiyama, Kazuhisa Ophthalmology 121 11 2153-2158 2014/01/01
- In vivo laser confocal microscopy findings of radial keratoneuritis in patients with early stage acanthamoeba keratitis Kobayashi, Akira; Yokogawa, Hideaki; Yamazaki, Natsuko; Ishibashi, Yasuhisa; Oikawa, Yosaburo; Tokoro, Masaharu; Sugiyama, Kazuhisa Ophthalmology 120 7 1348-1353 2013/07/01
- Rationale for performing penetrating keratoplasty rather than DSAEK in patients with bullous keratopathy in Japan Yokogawa, Hideaki; Kobayashi, Akira; Saito, Yoshiaki; Yamazaki, Natsuko; Masaki, Toshinori; Sugiyama, Kazuhisa Ophthalmic Surgery Lasers and Imaging 43 6 446-451 2012/11/01
- In vivo laser confocal microscopy after descemet's membrane endothelial keratoplasty Kobayashi, Akira; Yokogawa, Hideaki; Yamazaki, Natsuko; Masaki, Toshinori; Sugiyama, Kazuhisa Ophthalmology 120 5 923-930 2013/05/01
- Identification of cytomegalovirus and human herpesvirus-6 DNA in a patient with corneal endotheliitis Yokogawa, Hideaki; Kobayashi, Akira; Yamazaki, Natsuko; Sugiyama, Kazuhisa Japanese Journal of Ophthalmology 57 2 185-190 2013/03/01
- Mapping owl's eye cells of patients with cytomegalovirus corneal endotheliitis using in vivo laser confocal microscopy Yokogawa, Hideaki; Kobayashi, Akira; Sugiyama, Kazuhisa Japanese Journal of Ophthalmology 57 1 80-84 2013/01/01
- In vivo confocal microscopy and ultrasound biomicroscopy study of filtering blebs after trabeculectomy: Limbus-based versus fornix-based conjunctival flaps Morita, Koji; Gao, Yanlin; Saito, Yoshiaki; Higashide, Tomomi; Kobayashi, Akira; Ohkubo, Shinji; Sugiyama, Kazuhisa Journal of Glaucoma 21 6 383-391 2012/08/01
- In vivo laser confocal microscopy findings in patients with map-dot-fingerprint (epithelial basement membrane) dystrophy Kobayashi, Akira; Yokogawa, Hideaki; Sugiyama, Kazuhisa Clinical Ophthalmology 6 1 1187-1190 2012/07/26
- No-touch technique and a new donor adjuster for descemet's stripping automated endothelial keratoplasty Kobayashi, Akira; Yokogawa, Hideaki; Sugiyama, Kazuhisa Case Reports in Ophthalmology 3 2 214-220 2012/05/01
- Management of a small paracentral corneal perforation using iatrogenic iris incarceration and tissue adhesive Kobayashi, Akira; Yokogawa, Hideaki; Sugiyama, Kazuhisa Case Reports in Ophthalmology 3 2 226-229 2012/05/01
- Mathematical projection model of visual loss due to fuchs corneal dystrophy Hatou, Shin; Shimmura, Shigeto; Shimazaki, Jun; Usui, Tomohiko; Amano, Shiro; Yokogawa, Hideaki; Kobayashi, Akira; Zheng, Xiaodong; Shiraishi, Atsushi; Ohashi, Yuichi; Inatomi, Tsutomu; Tsubota, Kazuo Investigative Ophthalmology and Visual Science 52 11 7888-7893 2011/10/01
- In Vivo Laser Confocal Microscopy Findings of Thygeson Superficial Punctate Keratitis Kobayashi, Akira;Yokogawa, Hideaki;Sugiyama, Kazuhisa CORNEA 30 6 675-680 2011
- In vivo laser confocal microscopy after Descemet's membrane endothelial keratoplasty. 120 5 923-30
- In vivo laser confocal microscopy findings of radial keratoneuritis in patients with early stage acanthamoeba keratitis 120 7 1348-53 2013/07
- Visualization of precut DSAEK and pre-stripped DMEK donor corneas by intraoperative optical coherence tomography using the RESCAN 700 Kobayashi A, Yokogawa H, Mori N, Sugiyama K BMC Ophthalmology 2016
- Association of fluorescein anterior corneal mosaic and corneal K-structures by in vivo laser confocal microscopy in patients with keratoconus. Kobayashi A, Yokogawa H, Mori N, Masaki T, Sugiyama K Clinical ophthalmology 11 1359-1363 2017
- Rebamipide protects against glaucoma eyedrop-induced ocular surface disorders in rabbits. Kawaguchi I, Kobayashi A, Higashide T, Takeji Y, Sakurai K, Kawaguchi C, Sugiyama K PloS one 12 10 e0186714 2017
- Surgery-induced iris abnormalities after Descemet membrane endothelial keratoplasty and their impact on postoperative clinical outcomes. Mori N, Yokogawa H, Kobayashi A, Nishino T, Sugiyama K Clinical ophthalmology 2019
Conference Presentations
Others
- In vivo laser and white-light confocal microscopic findings of human conjunctiva. 35 482-484 2004
- In vivo confocal microscopy in the patients with central cloudy dystrophy of Francois. 122 1676-1679 2004
- Oxygen permeability of amniotic membrane and actual tear oxygen tension beneath amniotic membrane patch. 138 486-487 2004
- In vivo confocal microscopic findings of Palisade of Vogt and its underlying limbal stroma 24 435-437 2005
- Dtection of corneal epithelial defect through amniotic membrane patch by fluorescein. 24 359-360 2005
- Visualization of conjunctival cyst using trypan blue and healon V 24 759-760 2005
- In vivo confocal microscopy in a patient with keratopigmentation (corneal tatooing) 24 238-240 2005
- In vivo findings of bulbar/palpebral conjunctiva and presumed meibomian gland by laser scanning confocal microscopy. 24:985-988 2005
- Endogenous endophthalmitis caused by Enterococcus mundtii 43:1475-1476 2005
- Disappearance of honeycomb opacity of Thiel-Behnke corneal dystrophy after Thygeson's superficial punctuate keratitis. 24 1029-1030 2005
- In vivo laser confocal microscopic analysis of human corneal epithelial sheet cultured on amniotic membrane. 7:304-309 2006
- Bilateral corneal perforation in an infant with congenital alacrima. 43 236-238 2006
- Intraocular pressure by noncontact tonometry over an amniotic membrane patch in humans. 141 508-511 2006
- The influence of clinical factors on Blue-on-Yellow perimetry in diabetic patients without retinopathy -comparison with White-on-white perimetry 26;792-802 2006
- Truncation mutation in HRG4 (UNC119) leads to mitochondrial ANT-1-mediated degeneration in photoreceptor synapses and retinal degeneration by apoptosis. 47 1281-92 2006
- Measurement of light transmittance of cryopreserved human amniotic membrane 25 1080-1083 2006
- In vivo laser confocal microscopy of Bowman's layer of the cornea 113 2203-2208 2006
- In vivo laser confocal microscopy findings for Bowman's layer dystrophies(Thiel-Behnke and Reis-Bucklers corneal dystrophies) 114 69-75 2007
- Successful removal of a large conjunctival cyst using colored Healon V 38 81-83 2007
- Measurement of light transmission of human limbal epithelial cells cultured on human amniotic membranes 25 1080-1083 2007
- Postoperative retinal break after 25-gauge transconjunctival sutureless vitrectomy-report of four cases- 245 155-157 2007
- Targeted inactivation of synaptic HRG4 (UNC119) causes dysfunction in the distal photoreceptor and slow retinal degeneration, revealing a new function 84 473-485 2007
- In vivo laser confocal microscopy findings of corneal stromal dystrophies 125 1168-1173 2007
- Evaluation of visual acuity and color vision in normal human eyes with a sutureless temporary amniotic membrane patch 144 938-942 2007
- In vivo laser confocal microscopic analysis of murine cornea and lens microstructures 39 391-6 2008
- Descemet stripping with automated endothelial keratoplasty for bullous keratopathies secondary to argon laser iridotomy--preliminary results and usefulness of double-glide donor insertion technique 27 Suppl 1:S62-9 2007
- A flexible chandelier fiber probe holder for vitrectomy 28 1170 2008
- Mapping of normal corneal K-structures by in vivo laser confocal microscopy 27:879-83 2008
- In vivo laser confocal microscopy findings of cryopreserved and fresh human amniotic membrane 39:312-8 2008
- Non-Descemet stripping automated endothelial keratoplasty for endothelial dysfunction secondary to argon laser iridotomy 146:543-549 2008
- A new self-sealing cannula system for 20-gauge vitrectomy, outcomes of 247 consecutive cases 28 778-81 2008
- In vivo and ex vivo laser confocal microscopy findings in patients with early-stage acanthamoeba keratitis 27:439-45 2008
- In vivo laser confocal microscopy after descemet stripping with automated endothelial keratoplasty 145 977-985 2008
Arts and Fieldwork
Patent
Theme to the desired joint research
Grant-in-Aid for Scientific Research
○「水疱性角膜症に対する新しい角膜内皮移植術（DMEK）の確立と、術後視機能の解析」(2013-2015)
○「水疱性角膜症に対する新しい角膜内皮移植術(nDSAEK)の開発と包括的視機能解析」(2010-2011)
○「角膜，結膜，眼瞼におけるアポトーシス関連遺伝子の局在解明」(1999-)
○「角膜、結膜幹細胞の神経調節機構の解明」(2001-)
○「生体コンタクトレンズとしてのヒト羊膜の物理化学的性状の解析」(2004-)
○「ヒト角膜における新しい構造物（K-structure）の発見と臨床的意義の探求」(2007-)
○「新しい角膜内皮移植（DMEK/DMAEK/PDEK）の確立とドナー接着機構の解明」(2016-2018)
○「水疱性角膜症に対する新しい角膜内皮移植術（DMEK）の確立と、術後視機能の解析 」(2013-2015)
Competitive research funding,Contribution
Collaborative research,Consignment study
Classes (Bachelors)
○ophthalmology(2022)
○ophthalmology(2018)
○ophthalmology(2017)
○ophthalmology(2016)
Classes (Graduate Schools)
○Visual Science(2018)
○Visual Science(2017)
○Visual Science(2017)
○Visual Science(2017)
○Visual Science(2016)
○Visual Science(2016)