last modified：2024/01/08
Professor MIZUKOSHI Eishiro
Faculty, Affiliation
University Hospital
College and School Educational Field
Graduate School of Advanced Preventive Medical Sciences
School of Medicine, College of Medical, Pharmaceutical and Health Sciences
Laboratory
TEL:076-265-2235 FAX:076-234-4250
Academic Background
【Academic background(Bachelor's Degree)】
Kanazawa University 199203
Career
Kanazawa University(2002/04/01-)
National Institutes of Health Liver Diseases Section,NIDDK(1999/05/01-2001/08/31)
Year & Month of Birth
1967/11
Academic Society
Award
○Hamanako symposium research award(2004)
○Liver Forum in Kyoto research award(2007)
○Liver Forum in Kyoto research award(2007)
○Liver Forum in Kyoto research award(2007)
○Liver Forum in Kyoto research award(2007)
○Liver Forum in Kyoto research award(2007)
Specialities
Gastroenterology
Speciality Keywords
cancer, tumor immunology, hepatitis
Research Themes
cancer immunotherapy disease and host immune response steatohepatitis
Books
Papers
- Comparative analysis of various tumor-associated antigen-specific t-cell responses in patients with hepatocellular carcinoma. HEPATOLOGY 53 4 1216 2011/04
- Prolonged recurrence-free survival following OK432-stimulated dendritic cell transfer into hepatocellular carcinoma during transarterial embolization. 2010/11
- A liver-derived secretory protein, selenoprotein P, causes insulin resistance. 2010/11
- Differential gene expression profiling in blood from patients with digestive system cancers. 2010/09
- Enhancement of tumor-specific T-cell responses by transcatheter arterial embolization with dendritic cell infusion for hepatocellular carcinoma. Int J Cancer 126 9 2164 2010/05
- Common transcriptional signature of tumor-infiltrating mononuclear inflammatory cells and peripheral blood mononuclear cells in hepatocellular carcinoma patients. Honda M, Fujinaga H, Tatsumi I, Mizukoshi E, Nakamoto Y, Kaneko S 68(24) 10267-79 2008/12
- Hepatitis C virus (HCV)-specific immune responses of long-term injection drug users frequently exposed to HCV. Eisenbach C, Edlin BR, Newton KP, Raghuraman S, Weiler-Normann C, Tobler LH, Busch MP, Carrington M, McKeating JA, O'Brien TR, Rehermann B 198 203-12 2008/07
- Expression of multidrug resistance-associated protein 3 and cytotoxic T cell responses in patients with hepatocellular carcinoma. Mizukoshi E, Honda M, Arai K, Yamashita T, Nakamoto Y, Kaneko S. JOURNAL OF HEPATOLOGY 49 6 946 2008/06
- Impact of diabetes mellitus on prognosis of patients infected with hepatitis C virus. Mizukoshi E, Takamura T, Sakurai M, Takata Y, Arai K, Yamashita T, Nakamoto Y, Kaneko S 56 1682-8 2007/12
- Impact of diabetes on recurrence of hepatocellular carcinoma after surgical treatment in patients with viral hepatitis. Mizukoshi E, Kita Y, Sakurai M, Takata Y, Arai K, Yamashita T, Ohta T, Shimizu K, Nakamoto Y, Honda M, Takamura T, Kaneko S 102 1939-46 2007/09
- Virological effects and safety of combined double filtration plasmapheresis (DFPP) and interferon therapy in patients with chronic hepatitis C: A preliminary study. Arai K, Sakai A, Mizukoshi E, Sakai Y, Kagaya T, Nakamoto Y, Honda M, Wada T, Yokoyama H and Kaneko S 2006/11
- Cytotoxic T cell responses to human telomerase reverse transcriptase in patients with hepatocellular carcinoma. , Nakamoto Y, Marukawa Y, Arai K, Yamashita T, Tsuji H,Kuzushima K, Takiguchi M and Kaneko S 43 1284-1294 2006/06
- Foxp3+CD4+CD25+ T cells control virus-specific memory T cells in chimpanzees that recovered from hepatitis C. Blood. Manigold T, Shin EC, Mizukoshi E, Mihalik K, Murthy KK, Rice CM, Piccirillo CA and Rehermann B 107 4424-4432 2006/06
- Identification of alpha-fetoprotein-derived peptides recognized by cytotoxic T lymphocytes in HLA-A24+ patients with hepatocellular carcinoma. , Nakamoto Y, Tsuji H, Yamashita T and Kaneko S 118 1194-1204 2006/03
- Effects of antiviral therapy on the cellular immune response in acute hepatitis C. HEPATOLOGY 40 1 87-97 2004/07
- Kinetics of CD4+ and CD8+ memory T-cell responses during hepatitis C virus rechallenge of previously recovered chimpanzees. JOURNAL OF VIROLOGY 77 8 4781-4793 2003/04
- Molecular and immunological significance of chimpanzee major histocompatibility complex haplotypes for hepatitis C virus immune responses and vaccine studies JOURNAL OF VIROLOGY 76 12 6093-6103 2002/06
- Cross-reactivity between hepatitis C virus and Influenza A virus determinant-specific cytotoxic T cells JOURNAL OF VIROLOGY 75 23 11392-11400 2001/12
- Serum levels of soluble interferon Alfa/Beta receptor as an inhibitory factor of interferon in the patients with chronic hepatitis C HEPATOLOGY 30 5 1325-1331 1999/11
- Upregulation of Type I interferon receptor by IFN-gamma Journal of Interferon and Cytokine Research 19 9 1019-1023 1999/09
- Expression of interferon alpha/beta receptor in the liver of chronic hepatitis C patients Journal of Medical Virology 56 3 217-223 1998/11
Conference Presentations
Others
- Immune responses and immunity in hepatitis C virus infection. 36 12 799-808 2001/12
- Expression of multidrug resistance-associated protein 3 and cytotoxic T cell responses in patients with hepatocellular carcinoma. Honda M, Arai K, Yamashita T, Nakamoto Y, Kaneko S 49 946-54 2008
- Combined therapy of transcatheter hepatic arterial embolization with intratumoral dendritic cell infusion for hepatocellular carcinoma: clinical safety. Mizukoshi E, Tsuji H, Sakai Y, Kitahara M, Arai K, Yamashita T, Yokoyama K, Mukaida N, Matsushima K, Matsui O, Kaneko S 147 296-305 2007
Arts and Fieldwork
Patent
Theme to the desired joint research
Grant-in-Aid for Scientific Research
○「肝細胞癌に対する細胞性免疫治療に関する基礎的研究」(2003-)
○「癌特異抗原を用いた肝癌の細胞性免疫療法に関する基礎的検討」(2005-)
○「肝細胞癌治療後の再発制御を目的とした癌免疫療法の開発」(2007-)
○「ペプチドワクチンを用いた肝細胞癌免疫療法の開発」(2010-2011)
○「細胞傷害性T細胞レセプターを用いた肝細胞癌免疫治療に関する基礎的検討」(2013-2015)
○「Immunomeのシングルセル解析に基づいた肝癌新規分類法の確立」(2016-)
Competitive research funding,Contribution
Collaborative research,Consignment study
Classes (Bachelors)
Classes (Graduate Schools)
○Disease Control and Homeotasis(2017)
○Environment and Health -Introductory(2017)
○Disease Control and Homeotasis(2016)
○Environment and Health -Introductory(2016)